RGD Reference Report - Tumor collagenase stimulatory factor (TCSF) expression and localization in human lung and breast cancers. - Rat Genome Database

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Tumor collagenase stimulatory factor (TCSF) expression and localization in human lung and breast cancers.

Authors: Polette, M  Gilles, C  Marchand, V  Lorenzato, M  Toole, B  Tournier, JM  Zucker, S  Birembaut, P 
Citation: Polette M, etal., J Histochem Cytochem. 1997 May;45(5):703-9.
RGD ID: 2289059
Pubmed: PMID:9154157   (View Abstract at PubMed)

Tumor cell-derived collagenase stimulatory factor (TCSF) stimulates in vitro the biosynthesis of various matrix metalloproteinases involved in tumor invasion, such as interstitial collagenase, gelatinase A, and stromelysin 1. The expression of TCSF mRNAs was studied in vivo, using in situ hybridization and Northern blotting analysis, in seven normal tissues and in 22 squamous cell carcinomas of the lung, and in seven benign proliferations and in 22 ductal carcinomas of the mammary gland. By in situ hybridization, TCSF mRNAs were detected in 40 of 44 carcinomas, in pre-invasive and invasive cancer cells of both lung and breast cancers. TCSF mRNAs and gelatinase A mRNAs were both visualized in the same areas in serial sections in breast cancers, and were expressed by different cells, tumor cells, and fibroblasts. The histological results were confirmed by Northern blot analysis, which showed a higher expression of TCSF mRNAs in cancers than in benign and normal tissues. These observations support the hypothesis that TCSF is an important factor in lung and breast tumor progression.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BSGHumanbreast ductal carcinoma  IEP mRNA:increased expression:breastRGD 
BsgRatbreast ductal carcinoma  ISOBSG (Homo sapiens)mRNA:increased expression:breastRGD 
BsgMousebreast ductal carcinoma  ISOBSG (Homo sapiens)mRNA:increased expression:breastRGD 
BSGHumanlung squamous cell carcinoma  IEP mRNA:increased expression:lungRGD 
BsgRatlung squamous cell carcinoma  ISOBSG (Homo sapiens)mRNA:increased expression:lungRGD 
BsgMouselung squamous cell carcinoma  ISOBSG (Homo sapiens)mRNA:increased expression:lungRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bsg  (basigin)

Genes (Mus musculus)
Bsg  (basigin)

Genes (Homo sapiens)
BSG  (basigin (Ok blood group))


Additional Information