Dot1l (DOT1 like histone lysine methyltransferase) - Rat Genome Database
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Gene: Dot1l (DOT1 like histone lysine methyltransferase) Rattus norvegicus
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Symbol: Dot1l
Name: DOT1 like histone lysine methyltransferase
RGD ID: 1306644
Description: Predicted to have histone methyltransferase activity (H3-K79 specific) and transcription factor binding activity. Predicted to be involved in several processes, including DNA damage checkpoint; histone H3-K79 methylation; and regulation of transcription, DNA-templated. Predicted to localize to nucleoplasm and protein-containing complex. Human ortholog(s) of this gene implicated in mixed phenotype acute leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase); PARTICIPATES IN histone modification pathway; homocysteine metabolic pathway; methionine cycle/metabolic pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DOT1-like histone H3K79 methyltransferase; DOT1-like, histone H3 methyltransferase; DOT1-like, histone H3 methyltransferase (S. cerevisiae); histone-lysine N-methyltransferase, H3 lysine-79 specific; LOC362831
Orthologs:
Homo sapiens (human) : DOT1L (DOT1 like histone lysine methyltransferase)  HGNC  Alliance
Mus musculus (house mouse) : Dot1l (DOT1-like, histone H3 methyltransferase (S. cerevisiae))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dot1l (DOT1 like histone lysine methyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : DOT1L (DOT1 like histone lysine methyltransferase)
Canis lupus familiaris (dog) : DOT1L (DOT1 like histone lysine methyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dot1l (DOT1 like histone lysine methyltransferase)
Sus scrofa (pig) : DOT1L (DOT1 like histone lysine methyltransferase)
Chlorocebus sabaeus (African green monkey) : DOT1L (DOT1 like histone lysine methyltransferase)
Heterocephalus glaber (naked mole-rat) : Dot1l (DOT1 like histone lysine methyltransferase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0711,786,105 - 11,824,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,786,105 - 11,824,742 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,953,820 - 11,992,519 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,428,275 - 10,466,913 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1710,431,054 - 10,466,674 (-)NCBI
Celera77,100,524 - 7,139,150 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:14572310   PMID:15851025   PMID:17707234   PMID:22002246  


Genomics

Comparative Map Data
Dot1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0711,786,105 - 11,824,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,786,105 - 11,824,742 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,953,820 - 11,992,519 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,428,275 - 10,466,913 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1710,431,054 - 10,466,674 (-)NCBI
Celera77,100,524 - 7,139,150 (-)NCBICelera
Cytogenetic Map7q11NCBI
DOT1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl192,163,933 - 2,232,578 (+)EnsemblGRCh38hg38GRCh38
GRCh38192,163,933 - 2,232,578 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37192,164,148 - 2,232,577 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,115,148 - 2,181,015 (+)NCBINCBI36hg18NCBI36
Build 34192,115,147 - 2,181,014NCBI
Celera192,098,311 - 2,166,754 (+)NCBI
Cytogenetic Map19p13.3NCBI
HuRef191,935,055 - 2,003,614 (+)NCBIHuRef
CHM1_1192,163,729 - 2,232,081 (+)NCBICHM1_1
Dot1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,590,935 - 80,631,295 (+)NCBI
GRCm381080,755,101 - 80,795,461 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,755,206 - 80,795,461 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,217,951 - 80,257,092 (+)NCBIGRCm37mm9NCBIm37
MGSCv361080,158,335 - 80,197,476 (+)NCBImm8
Celera1081,773,573 - 81,812,716 (+)NCBICelera
Cytogenetic Map10C1NCBI
Dot1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,909,880 - 5,959,027 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,907,486 - 5,958,241 (-)NCBIChiLan1.0ChiLan1.0
DOT1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1192,147,008 - 2,215,262 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,147,031 - 2,210,039 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0191,173,915 - 1,243,633 (+)NCBIMhudiblu_PPA_v0panPan3
DOT1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2056,803,242 - 56,852,539 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12056,805,030 - 56,868,771 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dot1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365881,288,447 - 1,332,489 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOT1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,339,470 - 76,401,966 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,339,452 - 76,401,974 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,053,227 - 77,070,556 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DOT1L
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl61,962,279 - 2,026,455 (+)Ensembl
ChlSab1.161,962,077 - 2,030,732 (+)NCBI
Dot1l
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248286,648,403 - 6,697,617 (-)NCBI

Position Markers
AW907654  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0711,788,219 - 11,788,361NCBIRnor6.0
Rnor_5.0711,955,934 - 11,956,076UniSTSRnor5.0
RGSC_v3.4710,430,389 - 10,430,532UniSTSRGSC3.4
Celera77,102,638 - 7,102,780UniSTS
Cytogenetic Map7q11UniSTS
RH127906  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0711,787,149 - 11,787,337NCBIRnor6.0
Rnor_5.0711,954,864 - 11,955,052UniSTSRnor5.0
RGSC_v3.4710,429,319 - 10,429,507UniSTSRGSC3.4
Celera77,101,568 - 7,101,756UniSTS
Cytogenetic Map7q11UniSTS
RH 3.4 Map716.4UniSTS
RH134554  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0711,786,138 - 11,786,336NCBIRnor6.0
Rnor_5.0711,953,853 - 11,954,051UniSTSRnor5.0
RGSC_v3.4710,428,308 - 10,428,506UniSTSRGSC3.4
Celera77,100,557 - 7,100,755UniSTS
Cytogenetic Map7q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7134147172Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7134828535Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7134828535Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7137009673Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7138119654Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7265313832258115Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7591147750911477Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7595196950951969Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7975804554758045Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)71164710256647102Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:355
Count of miRNA genes:211
Interacting mature miRNAs:247
Transcripts:ENSRNOT00000051467
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 28 24 22 7 22 2 66 24 37 2
Low 1 15 33 19 12 19 8 9 8 11 4 9 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000051467   ⟹   ENSRNOP00000043691
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl711,786,105 - 11,824,742 (-)Ensembl
RefSeq Acc Id: NM_001108733   ⟹   NP_001102203
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,786,105 - 11,824,742 (-)NCBI
Rnor_5.0711,953,820 - 11,992,519 (-)NCBI
RGSC_v3.4710,428,275 - 10,466,913 (-)RGD
Celera77,100,524 - 7,139,150 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240959   ⟹   XP_006241021
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,787,083 - 11,824,737 (-)NCBI
Rnor_5.0711,953,820 - 11,992,519 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240960   ⟹   XP_006241022
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,787,083 - 11,824,737 (-)NCBI
Rnor_5.0711,953,820 - 11,992,519 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240961   ⟹   XP_006241023
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,787,083 - 11,824,737 (-)NCBI
Rnor_5.0711,953,820 - 11,992,519 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594910   ⟹   XP_017450399
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,787,083 - 11,810,213 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001102203   ⟸   NM_001108733
- UniProtKB: D3ZCP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241023   ⟸   XM_006240961
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006241022   ⟸   XM_006240960
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006241021   ⟸   XM_006240959
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017450399   ⟸   XM_017594910
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000043691   ⟸   ENSRNOT00000051467
Protein Domains
DOT1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695006
Promoter ID:EPDNEW_R5531
Type:multiple initiation site
Name:Dot1l_1
Description:DOT1 like histone lysine methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,824,739 - 11,824,799EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306644 AgrOrtholog
Ensembl Genes ENSRNOG00000032546 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000043691 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051467 ENTREZGENE, UniProtKB/TrEMBL
InterPro H3-K79_meTrfase UniProtKB/TrEMBL
  Histone_H3-K79_MeTrfase UniProtKB/TrEMBL
  Histone_H3-K79_MeTrfase_met UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
KEGG Report rno:362831 UniProtKB/TrEMBL
NCBI Gene 362831 ENTREZGENE
PANTHER PTHR21451 UniProtKB/TrEMBL
Pfam DOT1 UniProtKB/TrEMBL
PhenoGen Dot1l PhenoGen
PIRSF Histone_H3-K79_MeTrfase_met UniProtKB/TrEMBL
PROSITE DOT1 UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniGene Rn.228827 ENTREZGENE
UniProt D3ZCP0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Dot1l  DOT1 like histone lysine methyltransferase  Dot1l  DOT1-like histone H3K79 methyltransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-06-05 Dot1l  DOT1-like histone H3K79 methyltransferase  Dot1l  DOT1-like, histone H3 methyltransferase (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dot1l  DOT1-like, histone H3 methyltransferase (S. cerevisiae)   Dot1l_predicted  DOT1-like, histone H3 methyltransferase (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dot1l_predicted  DOT1-like, histone H3 methyltransferase (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED