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Gene: Shmt1 (serine hydroxymethyltransferase 1) Rattus norvegicus
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Symbol: Shmt1
Name: serine hydroxymethyltransferase 1
Description: Exhibits several functions, including L-allo-threonine aldolase activity; anion binding activity; and glycine hydroxymethyltransferase activity. Involved in glycine biosynthetic process from serine and protein homotetramerization. Localizes to the cytosol. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human SHMT1 (serine hydroxymethyltransferase 1); PARTICIPATES IN folate mediated one-carbon metabolic pathway; glycine metabolic pathway; glycine, serine and threonine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC287379; LRRGT00032; mShmt; serine hydroxymethyl transferase 1 (soluble); serine hydroxymethyltransferase 1 (soluble); serine hydroxymethyltransferase, cytosolic; Shmt
Orthologs:
Homo sapiens (human) : SHMT1 (serine hydroxymethyltransferase 1)  HGNC  Alliance
Mus musculus (house mouse) : Shmt1 (serine hydroxymethyltransferase 1 (soluble))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shmt1 (serine hydroxymethyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SHMT1 (serine hydroxymethyltransferase 1)
Canis lupus familiaris (dog) : SHMT1 (serine hydroxymethyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shmt1 (serine hydroxymethyltransferase 1)
Sus scrofa (pig) : SHMT1 (serine hydroxymethyltransferase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01047,030,813 - 47,059,216 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01046,802,986 - 46,831,051 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,936,605 - 46,964,779 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11046,948,782 - 46,971,713 (-)NCBI
Celera1044,724,251 - 44,752,341 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Shmt1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312011
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.