Mir136 (microRNA 136) - Rat Genome Database

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Gene: Mir136 (microRNA 136) Rattus norvegicus
Symbol: Mir136
Name: microRNA 136
RGD ID: 2325384
Description: Predicted to enable mRNA base-pairing translational repressor activity. Predicted to be involved in negative regulation of gene expression and positive regulation of immune response. Predicted to act upstream of or within epigenetic regulation of gene expression. Human ortholog(s) of this gene implicated in colorectal cancer; lung cancer; and lung non-small cell carcinoma. Orthologous to human MIR136 (microRNA 136); INTERACTS WITH bisphenol A; furan; genistein.
Type: ncrna (Ensembl: miRNA)
Previously known as: microRNA mir-136; rno-mir-136
RGD Orthologs
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.26128,549,096 - 128,549,177 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6128,549,096 - 128,549,177 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6128,689,167 - 128,689,248 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06128,985,005 - 128,985,086 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,346,619 - 128,346,700 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,716,761 - 133,716,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,716,761 - 133,716,842 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06142,878,938 - 142,879,019 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,097,307 - 126,097,388 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development. Chen YW, etal., J Immunol Res. 2021 Jun 24;2021:5510869. doi: 10.1155/2021/5510869. eCollection 2021.
2. Downregulation of miR‑136‑5p in hepatocellular carcinoma and its clinicopathological significance. Ding H, etal., Mol Med Rep. 2017 Oct;16(4):5393-5405. doi: 10.3892/mmr.2017.7275. Epub 2017 Aug 17.
3. Long non‑coding RNA NORAD promotes cell proliferation and glycolysis in non‑small cell lung cancer by acting as a sponge for miR‑136‑5p. Gao W, etal., Mol Med Rep. 2019 Jun;19(6):5397-5405. doi: 10.3892/mmr.2019.10210. Epub 2019 Apr 30.
4. Exosomal miR-136-5p Derived from Anlotinib-Resistant NSCLC Cells Confers Anlotinib Resistance in Non-Small Cell Lung Cancer Through Targeting PPP2R2A. Gu G, etal., Int J Nanomedicine. 2021 Sep 16;16:6329-6343. doi: 10.2147/IJN.S321720. eCollection 2021.
5. Circular RNA protein tyrosine kinase 2 (circPTK2) promotes colorectal cancer proliferation, migration, invasion and chemoresistance. Jiang Z, etal., Bioengineered. 2022 Jan;13(1):810-823. doi: 10.1080/21655979.2021.2012952.
6. miR-136 targets MIEN1 and involves the metastasis of colon cancer by suppressing epithelial-to-mesenchymal transition. Ren H, etal., Onco Targets Ther. 2017 Dec 22;11:67-74. doi: 10.2147/OTT.S113359. eCollection 2018.
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Overexpression of circRNA_100290 promotes the progression of laryngeal squamous cell carcinoma through the miR-136-5p/RAP2C axis. Wang Z, etal., Biomed Pharmacother. 2020 May;125:109874. doi: 10.1016/j.biopha.2020.109874. Epub 2020 Jan 31.
10. MicroRNA-136 inhibits colon cancer cell proliferation and invasion through targeting liver receptor homolog-1/Wnt signaling. Yuan Q, etal., Gene. 2017 Sep 10;628:48-55. doi: 10.1016/j.gene.2017.07.031. Epub 2017 Jul 12.
11. MiR-136 inhibits gastric cancer-specific peritoneal metastasis by targeting HOXC10. Zheng J, etal., Tumour Biol. 2017 Jun;39(6):1010428317706207. doi: 10.1177/1010428317706207.
Additional References at PubMed
PMID:15345052   PMID:16381832   PMID:17604727   PMID:19126398   PMID:20403161   PMID:24025743   PMID:28753453   PMID:29179211   PMID:30308489   PMID:30546117   PMID:31131445   PMID:32441195  
PMID:35084609   PMID:35766911  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.26128,549,096 - 128,549,177 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6128,549,096 - 128,549,177 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6128,689,167 - 128,689,248 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06128,985,005 - 128,985,086 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,346,619 - 128,346,700 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,716,761 - 133,716,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,716,761 - 133,716,842 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06142,878,938 - 142,879,019 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,097,307 - 126,097,388 (+)NCBICelera
Cytogenetic Map6q32NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3814100,884,702 - 100,884,783 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14100,884,702 - 100,884,783 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,351,039 - 101,351,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,420,791 - 100,420,872 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,404,861 - 81,404,942 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1481,532,773 - 81,532,854 (+)NCBIHuRef
CHM1_114101,289,230 - 101,289,311 (+)NCBICHM1_1
T2T-CHM13v2.01495,120,138 - 95,120,219 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3912109,561,761 - 109,561,822 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12109,561,761 - 109,561,822 (+)EnsemblGRCm39 Ensembl
GRCm3812109,595,327 - 109,595,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,595,327 - 109,595,388 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,833,537 - 110,833,598 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12110,790,028 - 110,790,089 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.39NCBI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1869,106,615 - 69,106,670 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl869,106,598 - 69,106,687 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,624,369 - 68,624,424 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0869,390,105 - 69,390,160 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1869,051,808 - 69,051,863 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0869,117,680 - 69,117,735 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,515,858 - 69,515,913 (+)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl7121,711,325 - 121,711,414 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17121,711,328 - 121,711,409 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27132,079,194 - 132,079,275 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:5026
Count of gene targets:3731
Count of transcripts:4020
Interacting mature miRNAs:rno-miR-136-3p, rno-miR-136-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

reproductive system
Low 2
Below cutoff


Nucleotide Sequences
RefSeq Transcripts NR_031882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000054601
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6128,549,096 - 128,549,177 (+)Ensembl
Rnor_6.0 Ensembl6133,716,761 - 133,716,842 (+)Ensembl
RefSeq Acc Id: NR_031882
Rat AssemblyChrPosition (strand)Source
mRatBN7.26128,549,096 - 128,549,177 (+)NCBI
Rnor_6.06133,716,761 - 133,716,842 (+)NCBI
Rnor_5.06142,878,938 - 142,879,019 (+)NCBI
Celera6126,097,307 - 126,097,388 (+)NCBI

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325384 AgrOrtholog
BioCyc Gene G2FUF-36175 BioCyc
Ensembl Genes ENSRNOG00000036493 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000054601 ENTREZGENE
miRBase MI0000909 ENTREZGENE
NCBI Gene 100314239 ENTREZGENE
PhenoGen Mir136 PhenoGen
RatGTEx ENSRNOG00000036493 RatGTEx
RNAcentral URS0000204177 RNACentral
  URS00004EAB18 RNACentral
  URS00006A186B RNACentral

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir136  microRNA 136  Mir136  microRNA mir-136  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir136  microRNA mir-136      Symbol and Name status set to provisional 70820 PROVISIONAL