RGD Reference Report - Gene polymorphisms of SFTPB rs7316, rs9752 and PAOX rs1046175 affect the diagnostic value of plasma Pro-SFTPB and DAS in Chinese Han non-small-cell lung cancer patients. - Rat Genome Database

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Gene polymorphisms of SFTPB rs7316, rs9752 and PAOX rs1046175 affect the diagnostic value of plasma Pro-SFTPB and DAS in Chinese Han non-small-cell lung cancer patients.

Authors: Wang, Kun  Huang, Qiubo  Zhao, Guangqiang  Yang, Jiapeng  Yang, Kaiyun  Huang, Yunchao 
Citation: Wang K, etal., J Cell Biochem. 2019 Sep;120(9):14804-14812. doi: 10.1002/jcb.28741. Epub 2019 Apr 23.
RGD ID: 151667418
Pubmed: PMID:31016788   (View Abstract at PubMed)
DOI: DOI:10.1002/jcb.28741   (Journal Full-text)

Plasma pro-surfactant protein B (pro-SFTPB) and N1,N12-diacetylspermine (DAS) can be used as markers for the diagnosis of non-small-cell lung carcinoma (NSCLC). Whether the genetic diversity affects the application value of Pro-SFTPB and DAS as a diagnostic marker for NSCLC is still unknown. This study aims to explore the relationship between SFTPB rs7316, rs9752 and PAOX rs1046175 gene polymorphisms and the diagnostic value of plasma Pro-SFTPB and DAS in patients with Chinese Han lung cancer. SFTPB rs7316, rs9752 and PAOX rs1046175 genotypes were analyzed by direct sequencing in 425 patients with NSCLC and 425 controls, and the levels of Pro-SFTPB and DAS in plasma were determined by enzyme-linked immunosorbent assay (ELISA). The area under the curve (AUC) of the SFTPB rs7316 locus TT genotype for the diagnosis of NSCLC was 0.758, and the AUC of the TC/CC genotype for the diagnosis of NSCLC was 0.872. The AUC of the SFTPB rs9752 locus GG genotype for the diagnosis of NSCLC was 0.935, and the AUC of the GC/CC genotype for the diagnosis of NSCLC was 0.648. The AUC of the PAOX rs1046175 locus GG for the diagnosis of NSCLC was 0.669, and the AUC of the GC/CC genotype for the diagnosis of NSCLC was 0.749. In conclusion, SFTPB rs7316, rs9752, and PAOX rs1046175 gene polymorphisms affect the diagnostic value of plasma Pro-SFTPB and DAS in patients with Chinese Han NSCLC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lung non-small cell carcinoma susceptibilityIAGP 151667418DNA:SNPs: :rs7316 and rs1046175(human)RGD 
lung non-small cell carcinoma susceptibilityISOPAOX (Homo sapiens)151667418; 151667418DNA:SNPs: :rs7316 and rs1046175(human)RGD 
lung non-small cell carcinoma susceptibilityIAGP 151667418DNA:SNPs: :rs7316 and rs9752 (human)RGD 
lung non-small cell carcinoma susceptibilityISOSFTPB (Homo sapiens)151667418; 151667418DNA:SNPs: :rs7316 and rs9752 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Paox  (polyamine oxidase)
Sftpb  (surfactant protein B)

Genes (Mus musculus)
Paox  (polyamine oxidase (exo-N4-amino))
Sftpb  (surfactant associated protein B)

Genes (Homo sapiens)
PAOX  (polyamine oxidase)
SFTPB  (surfactant protein B)


Additional Information