RGD Reference Report - BHLHB3: a candidate tumor suppressor in lung cancer. - Rat Genome Database

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BHLHB3: a candidate tumor suppressor in lung cancer.

Authors: Falvella, F S  Colombo, F  Spinola, M  Campiglio, M  Pastorino, U  Dragani, T A 
Citation: Falvella FS, etal., Oncogene. 2008 Jun 12;27(26):3761-4. doi: 10.1038/sj.onc.1211038. Epub 2008 Jan 28.
RGD ID: 151665316
Pubmed: PMID:18223678   (View Abstract at PubMed)
DOI: DOI:10.1038/sj.onc.1211038   (Journal Full-text)

BHLHB3 is a basic helix-loop-helix (bHLH) domain-containing protein that acts as a transcriptional repressor. We found that BHLHB3 transcript levels were low in three human lung cancer cell lines and downregulated in human lung adenocarcinomas as compared to normal lung tissue. BHLHB3 gene overexpression inhibited colony formation of A549, NCI-H520 and NCI-H596 lung cancer cells. The reduced colony growth was likely due to inhibition of cell proliferation as suggested by the downregulation of cyclin D1 (CCND1) expression in NCI-H520 cells transfected to overexpress the BHLHB3 gene; no evidence of apoptosis was observed. These results point to the potential role of the BHLHB3 protein as a tumor suppressor for lung cancer.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BHLHE41Humanlung adenocarcinoma  IEP mRNA:decreased expression:lung (human)RGD 
Bhlhe41Ratlung adenocarcinoma  ISOBHLHE41 (Homo sapiens)mRNA:decreased expression:lung (human)RGD 
Bhlhe41Mouselung adenocarcinoma  ISOBHLHE41 (Homo sapiens)mRNA:decreased expression:lung (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bhlhe41  (basic helix-loop-helix family, member e41)

Genes (Mus musculus)
Bhlhe41  (basic helix-loop-helix family, member e41)

Genes (Homo sapiens)
BHLHE41  (basic helix-loop-helix family member e41)


Additional Information