tetraterpene - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	tetraterpene	go back to main search page
Accession:	CHEBI:35193	browse the term
Definition:	A C40 terpene.
Synonyms:	related_synonym:	tetraterpenes; tetraterpeno; tetraterpenos

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Rat (600) Mouse (614) Human (610) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (600)

8'-apo-beta,psi-caroten-8'-al

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA dehydrogenase medium chain

increases expression

apocarotenal results in increased expression of ACADM mRNA

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

alcohol dehydrogenase 5 (class III), chi polypeptide

increases expression

apocarotenal results in increased expression of ADH5 mRNA

NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591

G

aldehyde dehydrogenase 1 family, member B1

decreases expression

apocarotenal results in decreased expression of ALDH1B1 mRNA

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 3 family, member B1

decreases expression

apocarotenal results in decreased expression of ALDH3B1 mRNA

NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921

G

aldehyde dehydrogenase 4 family, member A1

decreases expression

apocarotenal results in decreased expression of ALDH4A1 mRNA

NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345

G

ankyrin 2

increases expression

apocarotenal results in increased expression of ANK2 mRNA

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

G

ankyrin 3

increases expression

apocarotenal results in increased expression of ANK3 mRNA

NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300

G

N-acylsphingosine amidohydrolase 1

increases expression

apocarotenal results in increased expression of ASAH1 mRNA

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

ankyrin repeat and SOCS box-containing 1

increases expression

apocarotenal results in increased expression of ASB1 mRNA

NCBI chr 9:92,120,332...92,140,790
Ensembl chr 9:92,120,306...92,136,376

G

ankyrin repeat and SOCS box-containing 9

increases expression

apocarotenal results in increased expression of ASB9 mRNA

NCBI chr X:29,956,576...30,001,436
Ensembl chr X:29,956,576...30,001,105

G

BCL2 associated X, apoptosis regulator

decreases expression

apocarotenal results in decreased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

beta-carotene oxygenase 2

multiple interactions

[BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal; [BCO2 protein results in increased metabolism of Cryptoxanthins] which results in increased chemical synthesis of apocarotenal; [BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite; [BCO2 protein results in increased metabolism of Zeaxanthins] which results in increased chemical synthesis of apocarotenal metabolite

NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467

G

caspase 8 associated protein 2

increases expression

apocarotenal results in increased expression of CASP8AP2 mRNA

NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275

G

cadherin 1

increases expression

apocarotenal results in increased expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

claudin 10

increases expression

apocarotenal results in increased expression of CLDN10 mRNA

NCBI chr15:95,862,785...95,954,526
Ensembl chr15:95,862,760...95,954,526

G

claudin 18

increases expression

apocarotenal results in increased expression of CLDN18 mRNA

NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351

G

collagen type I alpha 1 chain

decreases expression

apocarotenal results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type IV alpha 1 chain

decreases expression

apocarotenal results in decreased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

collagen type IV alpha 2 chain

decreases expression

apocarotenal results in decreased expression of COL4A2 mRNA

NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839

G

cellular retinoic acid binding protein 2

decreases expression

apocarotenal results in decreased expression of CRABP2 mRNA

NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379

G

cathepsin B

decreases expression

apocarotenal results in decreased expression of CTSB mRNA

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

C-X-C motif chemokine ligand 12

increases expression

apocarotenal results in increased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 6

increases expression

apocarotenal results in increased expression of CXCL6 mRNA

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

C-X-C motif chemokine ligand 9

increases expression

apocarotenal results in increased expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

C-X-C motif chemokine receptor 4

increases expression

apocarotenal results in increased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

distal-less homeobox 2

increases expression

apocarotenal results in increased expression of DLX2 mRNA

NCBI chr 3:56,370,238...56,373,581
Ensembl chr 3:56,370,483...56,373,597

G

distal-less homeobox 4

increases expression

apocarotenal results in increased expression of DLX4 mRNA

NCBI chr10:80,085,037...80,090,434
Ensembl chr10:80,085,465...80,090,456

G

ERCC excision repair 2, TFIIH core complex helicase subunit

decreases expression

apocarotenal results in decreased expression of ERCC2 mRNA

NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102

G

ETS proto-oncogene 1, transcription factor

decreases expression

apocarotenal results in decreased expression of ETS1 mRNA

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

Fas cell surface death receptor

increases expression

apocarotenal results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

decreases expression

apocarotenal results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

GATA binding protein 6

increases expression

apocarotenal results in increased expression of GATA6 mRNA

NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532

G

guanylate binding protein 1

increases expression

apocarotenal results in increased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

glutathione S-transferase kappa 1

decreases expression

apocarotenal results in decreased expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

glutathione S-transferase mu 2

decreases expression

apocarotenal results in decreased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase mu 4

decreases expression

apocarotenal results in decreased expression of GSTM4 mRNA

NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323

G

glutathione S-transferase, mu 5-like

increases expression

apocarotenal results in increased expression of GSTM5 mRNA

NCBI chr 2:195,544,424...195,549,895
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase zeta 1

decreases expression

apocarotenal results in decreased expression of GSTZ1 mRNA

NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284

G

homeobox A7

increases expression

apocarotenal results in increased expression of HOXA7 mRNA

NCBI chr 4:81,315,730...81,317,629
Ensembl chr 4:81,314,625...81,317,659

G

homeo box B6

increases expression

apocarotenal results in increased expression of HOXB6 mRNA

NCBI chr10:81,258,726...81,267,458
Ensembl chr10:81,265,056...81,267,449

G

homeo box C10

increases expression

apocarotenal results in increased expression of HOXC10 mRNA

NCBI chr 7:134,103,741...134,108,966
Ensembl chr 7:134,103,643...134,108,966

G

interferon regulatory factor 8

increases expression

apocarotenal results in increased expression of IRF8 mRNA

NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829

G

iroquois homeobox 4

decreases expression

apocarotenal results in decreased expression of IRX4 mRNA

NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549

G

integrin subunit beta 4

decreases expression

apocarotenal results in decreased expression of ITGB4 mRNA

NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012

G

involucrin

increases expression

apocarotenal results in increased expression of IVL mRNA

NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100

G

keratin 17

decreases expression

apocarotenal results in decreased expression of KRT17 mRNA

NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392

G

keratin 2

increases expression

apocarotenal results in increased expression of KRT2 mRNA

NCBI chr 7:132,940,879...132,948,031
Ensembl chr 7:132,940,862...132,947,963

G

keratin 7

affects expression

apocarotenal affects the expression of KRT7 mRNA

NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052

G

LIM homeobox 3

increases expression

apocarotenal results in increased expression of LHX3 mRNA

NCBI chr 3:9,026,432...9,035,122
Ensembl chr 3:9,027,425...9,034,480

G

interferon alpha-1-like

increases expression

apocarotenal results in increased expression of IFNA5 mRNA

NCBI chr 5:103,227,820...103,230,500

G

MCL1 apoptosis regulator, BCL2 family member

affects expression

apocarotenal affects the expression of MCL1 mRNA

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

Meis homeobox 2

increases expression

apocarotenal results in increased expression of MEIS2 mRNA

NCBI chr 3:102,742,904...102,944,833
Ensembl chr 3:102,742,900...102,949,696

G

mesenchyme homeobox 1

increases expression

apocarotenal results in increased expression of MEOX1 mRNA

NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660

G

motor neuron and pancreas homeobox 1

increases expression

apocarotenal results in increased expression of MNX1 mRNA

NCBI chr 4:5,866,506...5,871,465
Ensembl chr 4:5,866,506...5,871,465

G

mutS homolog 5

increases expression

apocarotenal results in increased expression of MSH5 mRNA

NCBI chr20:3,773,867...3,793,337
Ensembl chr20:3,776,942...3,793,336

G

mucin 5AC, oligomeric mucus/gel-forming

increases expression

apocarotenal results in increased expression of MUC5AC mRNA

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

nitric oxide synthase 1

increases expression

apocarotenal results in increased expression of NOS1 mRNA

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

oxidized low density lipoprotein receptor 1

increases expression

apocarotenal results in increased expression of OLR1 mRNA

NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523

G

protocadherin gamma subfamily C, 3

increases expression

apocarotenal results in increased expression of PCDHGC3 mRNA

NCBI chr18:29,633,016...29,667,865
Ensembl chr18:29,493,954...29,667,868

G

phospholipid scramblase 1

increases expression

apocarotenal results in increased expression of PLSCR1 mRNA

NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692

G

phospholipid scramblase 3

increases expression

apocarotenal results in increased expression of PLSCR3 mRNA

NCBI chr10:54,566,556...54,573,240
Ensembl chr10:54,566,873...54,578,709

G

phospholipid scramblase 4

increases expression

apocarotenal results in increased expression of PLSCR4 mRNA

NCBI chr 8:92,987,290...93,026,056
Ensembl chr 8:92,987,381...93,026,049

G

RAD51 associated protein 1

increases expression

apocarotenal results in increased expression of RAD51AP1 mRNA

NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524

G

RAD51 paralog D

increases expression

apocarotenal results in increased expression of RAD51D mRNA

NCBI chr10:67,805,720...67,824,452
Ensembl chr10:67,740,712...67,824,434

G

retinoic acid receptor, alpha

decreases expression

apocarotenal results in decreased expression of RARA mRNA

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

retinoic acid receptor, beta

increases expression

apocarotenal results in increased expression of RARB mRNA

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

retinoic acid receptor responder 1

increases expression

apocarotenal results in increased expression of RARRES1 mRNA

NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978

G

SIX homeobox 6

increases expression

apocarotenal results in increased expression of SIX6 mRNA

NCBI chr 6:91,634,568...91,639,548
Ensembl chr 6:91,634,568...91,639,548

G

superoxide dismutase 1

decreases expression

apocarotenal results in decreased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

serine palmitoyltransferase, long chain base subunit 2

affects expression

apocarotenal affects the expression of SPTLC2 mRNA

NCBI chr 6:106,948,682...107,031,532
Ensembl chr 6:106,950,949...107,031,542

G

sterol regulatory element binding transcription factor 1

increases expression

apocarotenal results in increased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

transglutaminase 4

increases expression

apocarotenal results in increased expression of TGM4 mRNA

NCBI chr 8:122,689,429...122,726,463
Ensembl chr 8:122,689,429...122,726,463

G

TNF receptor superfamily member 9

increases expression

apocarotenal results in increased expression of TNFRSF9 mRNA

NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000

G

TNF superfamily member 10

increases expression

apocarotenal results in increased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

thioredoxin domain containing 9

increases expression

apocarotenal results in increased expression of TXNDC9 mRNA

NCBI chr 9:40,211,818...40,221,953
Ensembl chr 9:40,211,412...40,384,279
Ensembl chr 9:40,211,412...40,384,279

G

X-ray repair cross complementing 3

increases expression

apocarotenal results in increased expression of XRCC3 mRNA

NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444

9'-cis-neoxanthin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis inducing factor, mitochondria associated 1

affects localization

neoxanthin affects the localization of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

caspase 3

multiple interactions

neoxanthin results in increased cleavage of and results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

neoxanthin results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

neoxanthin results in increased cleavage of and results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

all-trans-neoxanthin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis inducing factor, mitochondria associated 1

affects localization

neoxanthin affects the localization of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

caspase 3

multiple interactions

neoxanthin results in increased cleavage of and results in increased activity of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

neoxanthin results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

neoxanthin results in increased cleavage of and results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

all-trans-phytoene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 1

multiple interactions

[(all-E) phytoene co-treated with phytofluene] inhibits the reaction [Estradiol results in increased activity of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

[(all-E) phytoene co-treated with phytofluene] inhibits the reaction [Estradiol results in increased activity of ESR2 protein]

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

all-trans-phytofluene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 1

multiple interactions

[(all-E) phytoene co-treated with phytofluene] inhibits the reaction [Estradiol results in increased activity of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

[(all-E) phytoene co-treated with phytofluene] inhibits the reaction [Estradiol results in increased activity of ESR2 protein]

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

alpha-carotene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

O-6-methylguanine-DNA methyltransferase

affects response to substance

MGMT gene SNP affects the susceptibility to alpha-carotene

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

astaxanthin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AKT serine/threonine kinase 1

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions

astaxanthine inhibits the reaction [thiacloprid results in decreased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

amyloid beta precursor protein

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

arginase 1

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of ARG1 mRNA]

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

autophagy related 12

multiple interactions

astaxanthine inhibits the reaction [bisphenol A results in increased expression of ATG12 mRNA]

NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418

G

autophagy related 14

multiple interactions

astaxanthine inhibits the reaction [bisphenol A results in increased expression of ATG14 mRNA]

NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113

G

BCL2 associated X, apoptosis regulator

multiple interactions

astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

beclin 1

multiple interactions

astaxanthine inhibits the reaction [bisphenol A results in increased expression of BECN1 mRNA]; astaxanthine inhibits the reaction [bisphenol A results in increased expression of BECN1 protein]

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

complement C1q A chain

decreases expression

astaxanthine results in decreased expression of C1QA mRNA

NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534

G

caspase 3

multiple interactions

astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA]
astaxanthine inhibits the reaction [thiacloprid results in decreased activity of CAT protein]

PMID:16964424 PMID:34564187

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin N-terminal domain containing 1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA]

NCBI chr10:86,221,430...86,231,812

G

collagen type II alpha 1 chain

multiple interactions

astaxanthine inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

cytochrome c oxidase assembly homolog COX15

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA]

NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261

G

cytochrome c oxidase subunit 5A

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA]

NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781

G

cytochrome c oxidase subunit 5B

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA]

NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052

G

cytochrome c oxidase subunit 6B1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA]

NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001
Ensembl chr 2:85,875,109...85,884,001

G

cytochrome c oxidase subunit 6C

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA]

NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963

G

cathepsin S

decreases expression

astaxanthine results in decreased expression of CTSS mRNA

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

cytochrome b-245 beta chain

multiple interactions
decreases expression

astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]]
astaxanthine results in decreased expression of CYBB mRNA

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

astaxanthine results in increased expression of and results in increased activity of CYP1A1 protein
astaxanthine results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

forkhead box O3

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA]

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

glucose-6-phosphate dehydrogenase

increases activity
multiple interactions

astaxanthine results in increased activity of G6PD protein
[Cadmium co-treated with astaxanthine] results in decreased activity of G6PD protein

PMID:28665548 PMID:29975440

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glial fibrillary acidic protein

decreases expression

astaxanthine results in decreased expression of GFAP mRNA

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

gap junction protein, alpha 1

increases expression
multiple interactions

astaxanthine results in increased expression of GJA1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [astaxanthine results in increased expression of GJA1 protein]; astaxanthine promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

G protein subunit alpha 13

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA]

NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774

G

glutamic--pyruvic transaminase

multiple interactions

astaxanthine inhibits the reaction [thiacloprid results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 3

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutathione peroxidase 4

multiple interactions
increases expression

astaxanthine inhibits the reaction [IL1B protein results in decreased expression of GPX4 protein]
astaxanthine results in increased expression of GPX4 protein
astaxanthine inhibits the reaction [erastin results in decreased expression of GPX4 protein]

PMID:36084724 PMID:37648051

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

glutamate ionotropic receptor NMDA type subunit 1

multiple interactions

[mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

granulin precursor

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

glutathione-disulfide reductase

multiple interactions

astaxanthine inhibits the reaction [Cadmium results in decreased activity of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 2

multiple interactions
increases expression

[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of GSTM2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of GSTM2 mRNA
astaxanthine results in increased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

high mobility group box 1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]
astaxanthine inhibits the reaction [thiacloprid results in increased expression of HMGB1 mRNA]

PMID:16964424 PMID:34564187

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

increases expression
multiple interactions
decreases expression

astaxanthine results in increased expression of HMOX1 protein
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein]
astaxanthine results in decreased expression of HMOX1 mRNA
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of HMOX1 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]
astaxanthine results in increased expression of HMOX1 mRNA
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of HMOX1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of HMOX1 mRNA; astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]

PMID:20038455 PMID:23272707 PMID:24157545 PMID:33008094 PMID:33212048

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

homeobox A9

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA]

NCBI chr 4:81,323,235...81,329,344
Ensembl chr 4:81,323,382...81,326,358

G

isocitrate dehydrogenase (NADP(+)) 1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA]

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

interferon gamma

increases expression

astaxanthine results in increased expression of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of IL10 mRNA]
astaxanthine inhibits the reaction [thiacloprid results in increased expression of IL10 protein]

PMID:33008094 PMID:34564187

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 11

increases expression

astaxanthine results in increased expression of IL11 protein

NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129

G

interleukin 1 beta

decreases expression
multiple interactions

astaxanthine results in decreased expression of IL1B mRNA; astaxanthine results in decreased expression of IL1B protein
astaxanthine inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]; astaxanthine inhibits the reaction [IL1B protein results in decreased expression of GPX4 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of P53 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; astaxanthine inhibits the reaction [thiacloprid results in increased expression of IL1B protein]
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of IL1B mRNA]

PMID:21621527 PMID:33008094 PMID:34564187 PMID:36084724

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

decreases expression
multiple interactions

astaxanthine results in decreased expression of IL6 mRNA
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of IL6 mRNA]

PMID:21621527 PMID:33008094

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

decreases expression

astaxanthine results in decreased expression of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

leptin receptor

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA]

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

mitogen activated protein kinase 1

multiple interactions

astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

matrix metallopeptidase 13

multiple interactions

astaxanthine inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA]

NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061

G

NADH:ubiquinone oxidoreductase subunit A1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA]

NCBI chr X:116,424,223...116,427,875
Ensembl chr X:116,424,223...116,428,633

G

NADH:ubiquinone oxidoreductase subunit A5

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA]

NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598

G

NADH:ubiquinone oxidoreductase subunit C2

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA]

NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189

G

NADH:ubiquinone oxidoreductase core subunit V2

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA]

NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713

G

NFE2 like bZIP transcription factor 2

increases expression
multiple interactions

astaxanthine results in increased expression of NFE2L2 protein
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein]
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NFE2L2 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]]
astaxanthine results in increased expression of NFE2L2 mRNA
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NFE2L2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NFE2L2 mRNA; astaxanthine promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 mRNA]

PMID:20038455 PMID:23272707 PMID:24157545 PMID:33008094 PMID:33212048

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NME/NM23 nucleoside diphosphate kinase 2

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA]

NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538

G

nitric oxide synthase 2

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NOS2 mRNA]; astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NOS2 protein]
astaxanthine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; astaxanthine inhibits the reaction [thiacloprid results in increased expression of NOS2 mRNA]

PMID:33008094 PMID:34564187 PMID:36084724

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NQO1 protein
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NQO1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NQO1 mRNA; astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of NQO1 mRNA]
astaxanthine results in increased expression of NQO1 mRNA
astaxanthine results in increased expression of NQO1 protein

PMID:20038455 PMID:24157545 PMID:33212048

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

phenylalanine hydroxylase

decreases expression

astaxanthine results in decreased expression of PAH mRNA

NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130

G

phosphogluconate dehydrogenase

increases activity

astaxanthine results in increased activity of PGD protein

PMID:28665548 PMID:29975440

NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778

G

cytochrome p450 oxidoreductase

decreases activity
increases expression

astaxanthine results in decreased activity of POR protein
astaxanthine results in increased expression of POR protein

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

protein phosphatase 1 catalytic subunit beta

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA]

NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824

G

peroxiredoxin 1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA]

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

phosphatase and tensin homolog

multiple interactions

astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of PTEN mRNA]

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions

astaxanthine results in decreased expression of PTGS2 mRNA
astaxanthine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of PTGS2 mRNA]

PMID:21621527 PMID:33008094 PMID:36084724

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ribosomal protein S2

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA]

NCBI chr10:13,747,316...13,749,165
Ensembl chr10:13,747,301...13,749,163

G

src kinase associated phosphoprotein 2

decreases expression

astaxanthine results in decreased expression of SKAP2 mRNA

NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891

G

superoxide dismutase 1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

Sp1 transcription factor

multiple interactions

[mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

secreted phosphoprotein 1

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA]

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

transglutaminase 2

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA]

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

G

transketolase

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA]

NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698

G

toll-like receptor 2

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TLR2 mRNA]

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TLR4 mRNA]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

decreases expression
multiple interactions
increases expression

astaxanthine results in decreased expression of TNF protein
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TNF mRNA]
astaxanthine results in increased expression of TNF protein

PMID:21621527 PMID:33008094 PMID:33132140

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

astaxanthine inhibits the reaction [Cyclophosphamide results in increased expression of TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

triggering receptor expressed on myeloid cells 2

multiple interactions

astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TREM2 mRNA]

NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170

G

ubiquitin B

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA]

NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,245,637...47,249,333

G

ubiquinol-cytochrome c reductase binding protein

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA]

NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150

G

ubiquinol cytochrome c reductase core protein 2

multiple interactions

astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA]

NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453

beta-carotene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA dehydrogenase family, member 9

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA

NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547

G

alcohol dehydrogenase 5 (class III), chi polypeptide

increases expression

beta Carotene results in increased expression of ADH5 mRNA

NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591

G

adiponectin, C1Q and collagen domain containing

decreases expression

beta Carotene results in decreased expression of ADIPOQ mRNA

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

AE binding protein 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA

NCBI chr14:80,738,800...80,748,878
Ensembl chr14:80,738,892...80,748,877

G

AKT serine/threonine kinase 1

decreases phosphorylation
decreases expression

beta Carotene results in decreased phosphorylation of AKT1 protein
beta Carotene results in decreased expression of AKT1 mRNA

PMID:26733226 PMID:36819991

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aminolevulinate dehydratase

multiple interactions

beta Carotene inhibits the reaction [arsenic trioxide results in decreased expression of ALAD protein]

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

aldehyde dehydrogenase 3 family, member B1

decreases expression

beta Carotene results in decreased expression of ALDH3B1 mRNA

NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921

G

aldehyde dehydrogenase 4 family, member A1

decreases expression

beta Carotene results in decreased expression of ALDH4A1 mRNA

NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345

G

ankyrin 2

increases expression

beta Carotene results in increased expression of ANK2 mRNA

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

G

ankyrin 3

increases expression

beta Carotene results in increased expression of ANK3 mRNA

NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300

G

amyloid beta precursor protein binding protein 2

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA

NCBI chr10:70,057,774...70,099,877
Ensembl chr10:70,057,774...70,099,835

G

Rho GTPase activating protein 26

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA

NCBI chr18:30,835,806...31,237,945
Ensembl chr18:30,838,671...31,235,194

G

N-acylsphingosine amidohydrolase 1

increases expression

beta Carotene results in increased expression of ASAH1 mRNA

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

ankyrin repeat and SOCS box-containing 1

increases expression

beta Carotene results in increased expression of ASB1 mRNA

NCBI chr 9:92,120,332...92,140,790
Ensembl chr 9:92,120,306...92,136,376

G

ankyrin repeat and SOCS box-containing 9

increases expression

beta Carotene results in increased expression of ASB9 mRNA

NCBI chr X:29,956,576...30,001,436
Ensembl chr X:29,956,576...30,001,105

G

ATPase phospholipid transporting 8B1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA

NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396

G

BAG cochaperone 3

decreases expression

beta Carotene results in decreased expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

BAG cochaperone 4

decreases expression

beta Carotene results in decreased expression of BAG4 mRNA

NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663

G

BAG cochaperone 5

decreases expression

beta Carotene results in decreased expression of BAG5 mRNA

NCBI chr 6:130,768,467...130,772,122
Ensembl chr 6:130,768,141...130,772,970

G

BCL2 associated X, apoptosis regulator

decreases expression
increases expression

beta Carotene results in decreased expression of BAX mRNA
beta Carotene results in increased expression of BAX mRNA; beta Carotene results in increased expression of BAX protein

PMID:15949688 PMID:17034753 PMID:26733226

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

beta Carotene results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

beta-carotene oxygenase 1

multiple interactions
affects response to substance
increases oxidation
increases expression

beta Carotene results in increased expression of and results in increased activity of BCO1 protein
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA
BCO1 protein results in increased oxidation of beta Carotene
beta Carotene results in increased expression of BCO1 mRNA
Ascorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]; Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]; Vitamin E inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]

PMID:9526112 PMID:16186334 PMID:24657404

NCBI chr19:45,149,250...45,186,102
Ensembl chr19:45,149,265...45,186,101

G

beta-carotene oxygenase 2

multiple interactions
increases metabolic processing

[BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal

NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467

G

caspase 3

multiple interactions
increases activity

alpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein]
beta Carotene metabolite results in increased activity of CASP3 protein; beta Carotene results in increased activity of CASP3 protein

PMID:17618090 PMID:26733226

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of CAT protein]; beta Carotene inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein]; beta Carotene inhibits the reaction [Indomethacin results in decreased expression of CAT protein]
beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein]

PMID:9306888 PMID:12500499 PMID:25542264 PMID:31022331

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

decreases expression

beta Carotene results in decreased expression of CAV1 protein

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

cyclin D1

decreases expression

beta Carotene results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cell division cycle associated 8

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA

NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629

G

cadherin 1

increases expression

beta Carotene results in increased expression of CDH1 mRNA; beta Carotene results in increased expression of CDH1 protein

PMID:17034753 PMID:26733226

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

CCAAT/enhancer binding protein alpha

decreases expression

beta Carotene results in decreased expression of CEBPA mRNA

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

centromere protein E

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA

NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669

G

CASP8 and FADD-like apoptosis regulator

increases expression

beta Carotene results in increased expression of CFLAR mRNA

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

chloride voltage-gated channel 3

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA

NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119

G

claudin 10

increases expression

beta Carotene results in increased expression of CLDN10 mRNA

NCBI chr15:95,862,785...95,954,526
Ensembl chr15:95,862,760...95,954,526

G

claudin 18

increases expression

beta Carotene results in increased expression of CLDN18 mRNA

NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351

G

collagen type I alpha 1 chain

decreases expression

beta Carotene results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type IV alpha 1 chain

decreases expression

beta Carotene results in decreased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

collagen type IV alpha 2 chain

decreases expression

beta Carotene results in decreased expression of COL4A2 mRNA

NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839

G

coenzyme Q7, hydroxylase

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA

NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158

G

carnitine palmitoyltransferase 1B

decreases expression

beta Carotene results in decreased expression of CPT1B mRNA

NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404

G

CASP2 and RIPK1 domain containing adaptor with death domain

increases expression

beta Carotene results in increased expression of CRADD mRNA

NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907

G

catenin alpha-like 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA

NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431

G

cathepsin B

decreases expression

beta Carotene results in decreased expression of CTSB mRNA

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

C-X-C motif chemokine ligand 12

increases expression

beta Carotene results in increased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 6

increases expression

beta Carotene results in increased expression of CXCL6 mRNA

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

C-X-C motif chemokine ligand 9

increases expression

beta Carotene results in increased expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

C-X-C motif chemokine receptor 4

increases expression

beta Carotene results in increased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 26, subfamily a, polypeptide 1

increases expression

beta Carotene results in increased expression of CYP26A1 mRNA

PMID:16186334 PMID:22542753

NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204

G

cytochrome P450, family 3, subfamily a, polypeptide 18

increases expression

beta Carotene results in increased expression of CYP3A43 mRNA

NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dihydrofolate reductase

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA

NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713

G

distal-less homeobox 2

increases expression

beta Carotene results in increased expression of DLX2 mRNA

NCBI chr 3:56,370,238...56,373,581
Ensembl chr 3:56,370,483...56,373,597

G

distal-less homeobox 4

increases expression

beta Carotene results in increased expression of DLX4 mRNA

NCBI chr10:80,085,037...80,090,434
Ensembl chr10:80,085,465...80,090,456

G

dipeptidylpeptidase 4

multiple interactions

[Xiao-Ke-An results in increased abundance of beta Carotene] which results in decreased activity of DPP4 protein

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

G

DTW domain containing 2

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA

NCBI chr18:42,811,783...42,902,040
Ensembl chr18:42,816,681...42,901,832

G

endothelin 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

ERCC excision repair 2, TFIIH core complex helicase subunit

decreases expression

beta Carotene results in decreased expression of ERCC2 mRNA

NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102

G

estrogen receptor 1

multiple interactions

beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA]

PMID:17051425 PMID:19340624

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR2 protein]

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

fatty acid binding protein 4

decreases expression

beta Carotene results in decreased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

Fas apoptotic inhibitory molecule 2

increases expression

beta Carotene results in increased expression of FAIM2 mRNA

NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168

G

Fas cell surface death receptor

increases expression

beta Carotene results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

FOS like 1, AP-1 transcription factor subunit

increases expression

beta Carotene results in increased expression of FOSL1 protein

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box A1

increases expression

beta Carotene results in increased expression of FOXA1 mRNA

NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188

G

forkhead box M1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

G

frizzled class receptor 6

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA

NCBI chr 7:70,055,012...70,086,781
Ensembl chr 7:70,055,068...70,086,776

G

GATA binding protein 6

increases expression

beta Carotene results in increased expression of GATA6 mRNA

NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532

G

guanylate binding protein 1

increases expression

beta Carotene results in increased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

gap junction protein, alpha 1

multiple interactions
increases expression

beta Carotene promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]; Ro 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein]
beta Carotene inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]; beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]

PMID:16091010 PMID:27154496

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glutathione-disulfide reductase

multiple interactions

beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase kappa 1

decreases expression

beta Carotene results in decreased expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

glutathione S-transferase mu 2

increases expression

beta Carotene results in increased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase mu 4

decreases expression

beta Carotene results in decreased expression of GSTM4 mRNA

NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323

G

glutathione S-transferase, mu 5-like

increases expression

beta Carotene results in increased expression of GSTM5 mRNA

NCBI chr 2:195,544,424...195,549,895
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase zeta 1

decreases expression

beta Carotene results in decreased expression of GSTZ1 mRNA

NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284

G

homeobox A7

increases expression

beta Carotene results in increased expression of HOXA7 mRNA

NCBI chr 4:81,315,730...81,317,629
Ensembl chr 4:81,314,625...81,317,659

G

homeo box B6

increases expression

beta Carotene results in increased expression of HOXB6 mRNA

NCBI chr10:81,258,726...81,267,458
Ensembl chr10:81,265,056...81,267,449

G

homeo box C10

increases expression

beta Carotene results in increased expression of HOXC10 mRNA

NCBI chr 7:134,103,741...134,108,966
Ensembl chr 7:134,103,643...134,108,966

G

hypoxanthine phosphoribosyltransferase 1

multiple interactions

beta Carotene inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene]

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

insulin-like growth factor binding protein 5

multiple interactions

[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA

NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156

G

interleukin 1 beta

multiple interactions

beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interferon regulatory factor 8

increases expression

beta Carotene results in increased expression of IRF8 mRNA

NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829

G

iroquois homeobox 4

decreases expression
multiple interactions

beta Carotene results in decreased expression of IRX4 mRNA
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA

PMID:17034753 PMID:24657404

NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549

G

integrin subunit beta 1

decreases expression

beta Carotene results in decreased expression of ITGB1 mRNA

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

integrin subunit beta 4

decreases expression

beta Carotene results in decreased expression of ITGB4 mRNA

NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012

G

integral membrane protein 2A

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA

NCBI chr X:72,486,383...72,492,344
Ensembl chr X:72,486,381...72,492,363

G

involucrin

increases expression

beta Carotene results in increased expression of IVL mRNA

NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

beta Carotene results in increased expression of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kinesin family member 11

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

G

keratin 18

increases expression

beta Carotene results in increased expression of KRT18 mRNA

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166

G

keratin 19

increases expression

beta Carotene results in increased expression of KRT19 mRNA

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

keratin 2

increases expression

beta Carotene results in increased expression of KRT2 mRNA

NCBI chr 7:132,940,879...132,948,031
Ensembl chr 7:132,940,862...132,947,963

G

keratin 7

affects expression

beta Carotene affects the expression of KRT7 mRNA

NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052

G

keratin 8

decreases expression

beta Carotene results in decreased expression of KRT8 mRNA

NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728

G

LanC like glutathione S-transferase 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA

NCBI chr 9:68,515,052...68,548,646
Ensembl chr 9:68,518,574...68,548,628

G

LIM homeobox 3

increases expression

beta Carotene results in increased expression of LHX3 mRNA

NCBI chr 3:9,026,432...9,035,122
Ensembl chr 3:9,027,425...9,034,480

G

lamin B2

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA

NCBI chr 7:8,792,628...8,808,665
Ensembl chr 7:8,789,314...8,808,665

G

interferon alpha-1-like

increases expression

beta Carotene results in increased expression of IFNA5 mRNA

NCBI chr 5:103,227,820...103,230,500

G

lipoprotein lipase

decreases expression

beta Carotene results in decreased expression of LPL mRNA

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

beta Carotene results in increased phosphorylation of MAPK1 protein
beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]

PMID:16206275 PMID:27154496

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

beta Carotene results in increased phosphorylation of MAPK3 protein
beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]

PMID:16206275 PMID:27154496

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mannose binding lectin 2

multiple interactions

MBL2 gene polymorphism affects the susceptibility to [Vitamin A co-treated with beta Carotene]

NCBI chr 1:228,016,439...228,024,736

G

MCL1 apoptosis regulator, BCL2 family member

affects expression

beta Carotene affects the expression of MCL1 mRNA

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

Meis homeobox 2

increases expression

beta Carotene results in increased expression of MEIS2 mRNA

NCBI chr 3:102,742,904...102,944,833
Ensembl chr 3:102,742,900...102,949,696

G

mesenchyme homeobox 1

increases expression

beta Carotene results in increased expression of MEOX1 mRNA

NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660

G

methyltransferase 21A, HSPA lysine

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA

NCBI chr 9:65,934,253...65,999,964
Ensembl chr 9:65,978,051...65,987,550

G

methyltransferase 9, His-X-His N1(pi)-histidine

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA

NCBI chr 1:175,575,805...175,623,065
Ensembl chr 1:175,577,890...175,623,061

G

O-6-methylguanine-DNA methyltransferase

affects response to substance

MGMT gene SNP affects the susceptibility to beta Carotene

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

marker of proliferation Ki-67

multiple interactions

[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

motor neuron and pancreas homeobox 1

increases expression

beta Carotene results in increased expression of MNX1 mRNA

NCBI chr 4:5,866,506...5,871,465
Ensembl chr 4:5,866,506...5,871,465

G

myeloperoxidase

multiple interactions

[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mitochondrial ribosomal protein L57

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA

NCBI chr15:31,970,904...31,971,766
Ensembl chr15:31,970,860...31,973,993

G

mutS homolog 5

increases expression

beta Carotene results in increased expression of MSH5 mRNA

NCBI chr20:3,773,867...3,793,337
Ensembl chr20:3,776,942...3,793,336

G

mitochondrial carrier 2

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA

NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189

G

mucin 5AC, oligomeric mucus/gel-forming

increases expression

beta Carotene results in increased expression of MUC5AC mRNA

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

NCK-associated protein 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA

NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217

G

nucleolar protein with MIF4G domain 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA

NCBI chr 4:5,891,220...5,910,741
Ensembl chr 4:5,892,909...5,909,709

G

nitric oxide synthase 1

increases expression

beta Carotene results in increased expression of NOS1 mRNA

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

multiple interactions

[Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]
beta Carotene results in increased activity of NR1I2 protein

PMID:15949683 PMID:16632523

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

oxidized low density lipoprotein receptor 1

increases expression

beta Carotene results in increased expression of OLR1 mRNA

NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523

G

par-6 family cell polarity regulator alpha

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA

NCBI chr19:33,589,531...33,591,900
Ensembl chr19:33,589,542...33,591,900

G

protocadherin 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA

NCBI chr18:30,011,692...30,039,679
Ensembl chr18:30,013,185...30,039,318

G

protocadherin gamma subfamily C, 3

increases expression

beta Carotene results in increased expression of PCDHGC3 mRNA

NCBI chr18:29,633,016...29,667,865
Ensembl chr18:29,493,954...29,667,868

G

platelet derived growth factor receptor beta

multiple interactions

[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA; [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

phosphoinositide-3-kinase, regulatory subunit 5

increases expression

beta Carotene results in increased expression of PIK3R5 protein

NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374

G

plasminogen activator, tissue type

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

phospholipid scramblase 1

increases expression

beta Carotene results in increased expression of PLSCR1 mRNA

NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692

G

phospholipid scramblase 3

increases expression

beta Carotene results in increased expression of PLSCR3 mRNA

NCBI chr10:54,566,556...54,573,240
Ensembl chr10:54,566,873...54,578,709

G

phospholipid scramblase 4

increases expression

beta Carotene results in increased expression of PLSCR4 mRNA

NCBI chr 8:92,987,290...93,026,056
Ensembl chr 8:92,987,381...93,026,049

G

peroxisome proliferator activated receptor alpha

decreases expression

beta Carotene results in decreased expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

decreases expression

beta Carotene results in decreased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

RAD51 associated protein 1

decreases expression

beta Carotene results in decreased expression of RAD51AP1 mRNA

NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524

G

RAD51 paralog D

increases expression

beta Carotene results in increased expression of RAD51D mRNA

NCBI chr10:67,805,720...67,824,452
Ensembl chr10:67,740,712...67,824,434

G

retinoic acid receptor, alpha

decreases expression

beta Carotene results in decreased expression of RARA mRNA

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

retinoic acid receptor, beta

increases expression

beta Carotene results in increased expression of RARB mRNA

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

retinoic acid receptor responder 1

increases expression

beta Carotene results in increased expression of RARRES1 mRNA

NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978

G

retinol binding protein 4

multiple interactions

beta Carotene results in decreased expression of and results in decreased secretion of RBP4 protein

NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399

G

RELA proto-oncogene, NF-kB subunit

decreases phosphorylation

beta Carotene results in decreased phosphorylation of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ribonuclease P/MRP subunit p14

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA

NCBI chr15:16,837,796...16,847,970
Ensembl chr15:16,836,859...16,852,101
Ensembl chr15:16,836,859...16,852,101

G

ribonucleotide reductase catalytic subunit M1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA

NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261

G

retinoid X receptor alpha

multiple interactions

beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

scavenger receptor class B, member 1

increases transport

SCARB1 protein results in increased transport of beta Carotene

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

SIX homeobox 6

increases expression

beta Carotene results in increased expression of SIX6 mRNA

NCBI chr 6:91,634,568...91,639,548
Ensembl chr 6:91,634,568...91,639,548

G

solute carrier family 2 member 4

decreases expression

beta Carotene results in decreased expression of SLC2A4 mRNA

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

superoxide dismutase 1

decreases expression

beta Carotene results in decreased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions

[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of SOD2 mRNA; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 mRNA]; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]

PMID:18779489 PMID:23859036

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

serine palmitoyltransferase, long chain base subunit 2

affects expression

beta Carotene affects the expression of SPTLC2 mRNA

NCBI chr 6:106,948,682...107,031,532
Ensembl chr 6:106,950,949...107,031,542

G

sterol regulatory element binding transcription factor 1

increases expression

beta Carotene results in increased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

transcription factor CP2

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA

NCBI chr 7:131,616,777...131,658,995
Ensembl chr 7:131,616,785...131,658,939

G

transglutaminase 2

increases expression

beta Carotene results in increased expression of TGM2 mRNA

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

G

transglutaminase 4

increases expression

beta Carotene results in increased expression of TGM4 mRNA

NCBI chr 8:122,689,429...122,726,463
Ensembl chr 8:122,689,429...122,726,463

G

THO complex subunit 7

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA

NCBI chr15:11,262,362...11,277,200
Ensembl chr15:11,262,613...11,277,193

G

transmembrane protein 209

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA

NCBI chr 4:59,102,943...59,128,636
Ensembl chr 4:59,101,550...59,128,630

G

tumor necrosis factor

multiple interactions

beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]; beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]; Quercetin affects the reaction [beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]
beta Carotene promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

PMID:19135038 PMID:21447443

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 9

increases expression

beta Carotene results in increased expression of TNFRSF9 mRNA

NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000

G

TNF superfamily member 10

increases expression

beta Carotene results in increased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

tetratricopeptide repeat domain 21B

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA

NCBI chr 3:50,861,367...50,935,880
Ensembl chr 3:50,861,367...50,935,903

G

twinfilin actin-binding protein 1

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA

NCBI chr 7:125,715,938...125,727,834
Ensembl chr 7:125,716,015...125,727,894

G

thioredoxin domain containing 9

increases expression

beta Carotene results in increased expression of TXNDC9 mRNA

NCBI chr 9:40,211,818...40,221,953
Ensembl chr 9:40,211,412...40,384,279
Ensembl chr 9:40,211,412...40,384,279

G

thymidine phosphorylase

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA

NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

G

vascular endothelial growth factor A

decreases expression

beta Carotene results in decreased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

X-ray repair cross complementing 3

increases expression

beta Carotene results in increased expression of XRCC3 mRNA

NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444

G

YTH N6-methyladenosine RNA binding protein C2

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA

NCBI chr18:37,266,559...37,331,681
Ensembl chr18:37,265,836...37,331,023

G

zinc finger DHHC-type palmitoyltransferase 3

multiple interactions

[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA

NCBI chr 8:122,725,206...122,773,542
Ensembl chr 8:122,715,111...122,773,529

bixin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

NFE2 like bZIP transcription factor 2

decreases ubiquitination

bixin results in decreased ubiquitination of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

canthaxanthin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

Canthaxanthin results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

Canthaxanthin results in increased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

capsanthin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

gap junction protein, alpha 1

multiple interactions

capsanthin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]; capsanthin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

mitogen activated protein kinase 1

multiple interactions

capsanthin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

capsanthin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

carotenoid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

beta-carotene oxygenase 2

decreases metabolic processing
multiple interactions

BCO2 gene mutant form results in decreased metabolism of Carotenoids
[[BCO2 gene mutant form results in decreased metabolism of Carotenoids] which results in increased abundance of Carotenoids] which results in increased expression of SOD2 protein; [BCO2 gene mutant form results in decreased metabolism of Carotenoids] which results in increased abundance of Carotenoids; BCO2 protein results in increased oxidation of and results in increased cleavage of Carotenoids

NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467

G

catalase

increases activity

Carotenoids results in increased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects response to substance

CYP1A2 protein polymorphism affects the susceptibility to Carotenoids

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

N-acetyltransferase 1

affects response to substance

NAT1 protein polymorphism affects the susceptibility to Carotenoids

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

N-acetyltransferase 2

affects response to substance

NAT2 protein polymorphism affects the susceptibility to Carotenoids

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

peroxisome proliferator-activated receptor gamma

decreases expression

Carotenoids results in decreased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

retinoic acid receptor, gamma

increases expression

Carotenoids results in increased expression of RARG mRNA

NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177

G

superoxide dismutase 2

multiple interactions
increases expression

[[BCO2 gene mutant form results in decreased metabolism of Carotenoids] which results in increased abundance of Carotenoids] which results in increased expression of SOD2 protein
Carotenoids results in increased expression of SOD2 protein

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

crocin-1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acid phosphatase 5, tartrate resistant

multiple interactions

crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

AKT serine/threonine kinase 2

multiple interactions

crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

BMP and activin membrane-bound inhibitor

multiple interactions

crocin inhibits the reaction [Cisplatin results in decreased expression of BAMBI mRNA]

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; crocin inhibits the reaction [Diazinon results in increased expression of BAX mRNA]; crocin inhibits the reaction [Diazinon results in increased expression of BAX protein]; crocin inhibits the reaction [Malathion results in increased expression of BAX protein]
crocin results in increased expression of BAX mRNA
crocin inhibits the reaction [Zearalenone results in increased expression of BAX protein]

PMID:23523949 PMID:26231423 PMID:27353299 PMID:32886819 PMID:32920515 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[crocin co-treated with Paraquat] results in decreased expression of BCL2 mRNA; crocin inhibits the reaction [Zearalenone results in decreased expression of BCL2 protein]
crocin results in decreased expression of BCL2 mRNA
crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]

PMID:26231423 PMID:31911963 PMID:32886819 PMID:32920515

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

brain-derived neurotrophic factor

increases expression

crocin results in increased expression of BDNF mRNA; crocin results in increased expression of BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

baculoviral IAP repeat-containing 5

decreases expression

crocin results in decreased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

caspase 3

multiple interactions
increases cleavage
increases expression
increases activity

crocin affects the reaction [Ethanol results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased cleavage of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased expression of CASP3 protein modified form]; crocin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; crocin inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
crocin results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein]
crocin inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]
crocin results in increased expression of CASP3 mRNA

PMID:23523949 PMID:25637687 PMID:25899501 PMID:26807765 PMID:27353299 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

crocin results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases activity

crocin inhibits the reaction [Diazinon results in increased cleavage of CASP9 protein]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]
crocin results in increased activity of CASP9 protein

PMID:27353299 PMID:32886819 PMID:35274200

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
increases activity
decreases activity

crocin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; crocin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; crocin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
crocin results in increased activity of CAT protein
crocin inhibits the reaction [Patulin results in increased activity of CAT protein]; crocin inhibits the reaction [Zearalenone results in increased activity of CAT protein]
crocin results in decreased activity of CAT protein

PMID:25899501 PMID:26231423 PMID:26584762 PMID:29409856 PMID:32886819 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin D1

decreases expression

crocin results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

creatine kinase, M-type

multiple interactions

crocin inhibits the reaction [Diazinon results in increased activity of CKM protein]

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

collagen type II alpha 1 chain

multiple interactions

[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

cAMP responsive element binding protein 1

multiple interactions

crocin results in increased expression of and results in increased phosphorylation of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cytochrome c, somatic

multiple interactions

crocin inhibits the reaction [Diazinon affects the localization of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases activity

crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein]
crocin results in decreased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

forkhead box P2

increases expression

crocin results in increased expression of FOXP2 protein

NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683

G

glyoxalase 1

multiple interactions

crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

G

glutamic--pyruvic transaminase

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased activity of GPT protein]
crocin inhibits the reaction [Zearalenone results in increased expression of GPT protein]

PMID:26231423 PMID:32259551

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

heme oxygenase 1

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 1 like

multiple interactions

crocin inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA]

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

interleukin 10

multiple interactions

crocin inhibits the reaction [Doxorubicin results in decreased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]

PMID:24709313 PMID:26807765

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
decreases expression

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; crocin inhibits the reaction [Ethanol results in decreased expression of IL6 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
crocin results in decreased expression of IL6 mRNA

PMID:25637687 PMID:25899501 PMID:29409856 PMID:32886819 PMID:32920515

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

crocin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

Janus kinase 2

multiple interactions

crocin affects the expression of and affects the phosphorylation of JAK2 protein

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Kelch-like ECH-associated protein 1

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

low density lipoprotein receptor

multiple interactions

crocin inhibits the reaction [Diazinon results in decreased expression of LDLR mRNA]

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK1 protein]
crocin results in decreased phosphorylation of MAPK1 protein

PMID:24132704 PMID:28689058 PMID:32886819

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK3 protein]
crocin results in decreased phosphorylation of MAPK3 protein
crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]

PMID:24132704 PMID:28689058 PMID:30580027 PMID:32886819

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microRNA 122

multiple interactions
decreases expression

crocin inhibits the reaction [bisphenol A results in increased expression of MIR122 mRNA]
crocin results in decreased expression of MIR122

PMID:28689058 PMID:36988377

NCBI chr18:58,758,703...58,758,787

G

microRNA 29b-1

increases expression
multiple interactions

crocin results in increased expression of MIR29B1 mRNA
Cisplatin inhibits the reaction [crocin results in increased expression of MIR29B1 mRNA]; crocin inhibits the reaction [Cisplatin results in decreased expression of MIR29B1 mRNA]

NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067

G

microRNA 34a

multiple interactions

MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein]

NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103

G

myeloperoxidase

multiple interactions

crocin inhibits the reaction [Ethanol results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

crocin results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYCN proto-oncogene, bHLH transcription factor

decreases response to substance
multiple interactions
decreases expression

MYCN results in decreased susceptibility to crocin
crocin results in decreased expression of and results in decreased stability of MYCN mRNA; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein]
crocin results in decreased expression of MYCN protein

NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590

G

MYD88, innate immune signal transduction adaptor

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 protein]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NFE2 like bZIP transcription factor 2

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 protein]; crocin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein]

PMID:32259551 PMID:32920515

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

osteoclastogenesis associated transmembrane protein 1

multiple interactions

[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]

NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

prostaglandin-endoperoxide synthase 2

decreases expression

crocin results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 4

multiple interactions
increases expression

MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein]

NCBI chr13:30,772,012...30,952,340
Ensembl chr13:30,776,682...30,952,170

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of RELA protein]; crocin inhibits the reaction [Streptozocin results in increased expression of RELA protein]

PMID:29409856 PMID:32920515

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

SMAD family member 2

decreases expression
multiple interactions

crocin results in decreased expression of SMAD2 protein
Cisplatin inhibits the reaction [crocin results in decreased expression of SMAD2 protein]; crocin inhibits the reaction [Cisplatin results in increased expression of SMAD2 protein]

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

synuclein alpha

multiple interactions

crocin inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; crocin inhibits the reaction [Malathion results in increased expression of SNCA protein]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

sprouty RTK signaling antagonist 2

increases expression

crocin results in increased expression of SPRY2 protein

NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009

G

signal transducer and activator of transcription 3

multiple interactions

crocin affects the expression of and affects the phosphorylation of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transforming growth factor, beta 1

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]

PMID:29409856 PMID:32259551

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 1

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased expression of TGFBR1 protein]

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

toll-like receptor 4

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TLR4 protein]

PMID:29409856 PMID:32259551

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
decreases expression

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; crocin inhibits the reaction [Ethanol results in decreased expression of TNF protein]
crocin results in decreased expression of TNF mRNA

PMID:25637687 PMID:25899501 PMID:26807765 PMID:32886819 PMID:32920515

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 11

multiple interactions

[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]; crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

troponin T2, cardiac type

multiple interactions

crocin inhibits the reaction [Doxorubicin results in increased expression of TNNT2 protein]

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

G

tumor protein p53

multiple interactions

crocin inhibits the reaction [Paraquat results in increased expression of TRP53 mRNA]; crocin inhibits the reaction [Zearalenone results in increased expression of TRP53 protein]

PMID:26231423 PMID:31911963

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TNF receptor associated factor 6

multiple interactions

crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

G

VGF nerve growth factor inducible

increases expression

crocin results in increased expression of VGF protein

NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341

fucoxanthin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA oxidase 1

increases expression

fucoxanthin results in increased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

actin, alpha 1, skeletal muscle

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ACTA1 mRNA]

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

adenylate cyclase 7

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased methylation of ADCY7 gene]; fucoxanthin inhibits the reaction [Glucose results in increased expression of ADCY7 mRNA]

NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311

G

adenylate kinase 8

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of AK8 mRNA]

NCBI chr 3:12,028,895...12,144,468
Ensembl chr 3:12,028,954...12,144,465

G

AKT serine/threonine kinase 1

multiple interactions
decreases expression

fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of AKT1 protein]
fucoxanthin results in decreased expression of AKT1 mRNA

PMID:26418808 PMID:35266250

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

activated leukocyte cell adhesion molecule

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of ALCAM mRNA]

NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954

G

ankyrin repeat domain 61

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ANKRD61 mRNA]

NCBI chr12:10,718,908...10,723,267
Ensembl chr12:10,718,908...10,723,265

G

Rho GDP dissociation inhibitor beta

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ARHGDIB mRNA]

NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658

G

armadillo repeat containing, X-linked 6

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of ARMCX6 mRNA]

NCBI chr X:97,929,032...97,932,031
Ensembl chr X:97,929,041...97,931,977

G

autophagy related 10

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of ATG10 mRNA]

NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ATP2A1 mRNA]

NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838

G

BMP and activin membrane-bound inhibitor

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of BAMBI mRNA]

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

G

butyrylcholinesterase

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of BCHE mRNA]

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

decreases expression

fucoxanthin results in decreased expression of BCL2 mRNA; fucoxanthin results in decreased expression of BCL2 protein

PMID:35266250 PMID:38444163

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [fucoxanthin results in decreased expression of BCL2L1 protein]; BCL2L1 protein inhibits the reaction [fucoxanthin results in increased cleavage of PARP1 protein]; STAT3 protein inhibits the reaction [fucoxanthin results in decreased expression of BCL2L1 protein]

PMID:20594983 PMID:38444163

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

baculoviral IAP repeat-containing 5

decreases expression

fucoxanthin results in decreased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

caspase 3

increases cleavage
multiple interactions

fucoxanthin results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions
increases cleavage

Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

castor zinc finger 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of CASZ1 mRNA]

NCBI chr 5:159,243,965...159,393,935
Ensembl chr 5:159,243,995...159,393,400

G

catalase

multiple interactions

fucoxanthin inhibits the reaction [Carrageenan results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

coiled-coil domain containing 116

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of CCDC116 mRNA]

NCBI chr11:83,842,707...83,850,607
Ensembl chr11:83,845,557...83,850,607

G

C-C motif chemokine receptor 10

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of CCR10 mRNA]

NCBI chr10:86,108,551...86,110,988
Ensembl chr10:86,108,551...86,110,988

G

CD1d1 molecule

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of CD1D1 mRNA]

NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089

G

cadherin, EGF LAG seven-pass G-type receptor 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of CELSR1 mRNA]

NCBI chr 7:116,987,616...117,125,035
Ensembl chr 7:116,987,605...117,125,164

G

cell migration inducing hyaluronidase 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of CEMIP mRNA]

NCBI chr 1:137,906,921...138,062,430
Ensembl chr 1:137,908,920...138,062,415

G

complement factor properdin

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of CFP mRNA]

NCBI chr X:1,162,014...1,167,576
Ensembl chr X:1,161,979...1,167,573

G

calponin 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of CNN1 mRNA]

NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098

G

collagen type VII alpha 1 chain

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of COL7A1 mRNA]

NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252

G

carboxypeptidase Q

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of CPQ mRNA]

NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546

G

cytokine receptor-like factor 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of CRLF1 mRNA]

NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,924,722...18,935,997

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of CYP2E1 mRNA]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

dispatched RND transporter family member 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of DISP2 mRNA]

NCBI chr 3:105,762,303...105,777,826
Ensembl chr 3:105,762,305...105,777,800

G

dematin actin binding protein

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of DMTN mRNA]

NCBI chr15:45,677,974...45,702,261
Ensembl chr15:45,677,977...45,705,601

G

dopamine receptor D3

increases activity

fucoxanthin results in increased activity of DRD3 protein

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

dopamine receptor D4

increases activity

fucoxanthin results in increased activity of DRD4 protein

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

dual specificity phosphatase 13B

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of DUSP13B mRNA]

NCBI chr15:2,567,432...2,575,105
Ensembl chr15:2,533,547...2,575,539

G

endosome-lysosome associated apoptosis and autophagy regulator 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of ELAPOR1 mRNA]

NCBI chr 2:196,089,199...196,169,055
Ensembl chr 2:196,091,646...196,168,716

G

epithelial splicing regulatory protein 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of ESRP1 mRNA]

NCBI chr 5:24,427,611...24,482,157
Ensembl chr 5:24,428,717...24,482,062

G

family with sequence similarity 78, member B

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of FAM78B mRNA]

NCBI chr13:79,162,393...79,250,958
Ensembl chr13:79,162,228...79,250,500

G

family with sequence similarity 83, member C

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of FAM83C mRNA]

NCBI chr 3:144,333,736...144,339,758
Ensembl chr 3:144,332,982...144,339,802

G

family with sequence similarity 98, member C

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of FAM98C mRNA]

NCBI chr 1:84,452,806...84,456,414
Ensembl chr 1:84,452,814...84,456,385

G

fructose-bisphosphatase 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of FBP2 mRNA]

NCBI chr17:2,236,088...2,253,702
Ensembl chr17:2,236,336...2,253,698

G

FCH and mu domain containing endocytic adaptor 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of FCHO1 mRNA]

NCBI chr16:18,413,452...18,430,795
Ensembl chr16:18,413,363...18,435,104

G

fibroblast growth factor 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of FGF1 mRNA]

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibrinogen-like 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of FGL2 mRNA]

NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207

G

filaggrin

decreases expression

fucoxanthin results in decreased expression of FLG mRNA

NCBI chr 2:178,884,793...178,912,986

G

golgi associated kinase 1B

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of GASK1B mRNA]

NCBI chr 2:165,047,689...165,112,479
Ensembl chr 2:165,047,684...165,112,477

G

gap junction protein, alpha 1

increases expression

fucoxanthin results in increased expression of GJA1 mRNA; fucoxanthin results in increased expression of GJA1 protein

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, beta 1

increases expression

fucoxanthin results in increased expression of GJB1 mRNA; fucoxanthin results in increased expression of GJB1 protein

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

G protein subunit gamma 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of GNG2 mRNA]

NCBI chr15:4,316,038...4,416,918
Ensembl chr15:4,316,059...4,417,183

G

glycoprotein m6b

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of GPM6B mRNA]

NCBI chr X:28,057,788...28,204,409
Ensembl chr X:28,059,450...28,204,211

G

glutamate ionotropic receptor NMDA type subunit 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of GRIN1 mRNA]

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glycophorin C

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of GYPC mRNA]

NCBI chr18:24,160,738...24,193,408
Ensembl chr18:24,160,739...24,193,204

G

hedgehog acyltransferase

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of HHAT mRNA]

NCBI chr13:104,024,507...104,283,580
Ensembl chr13:104,010,916...104,282,893

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases activity

fucoxanthin results in decreased activity of HMGCR protein

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

increases expression

fucoxanthin results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hormonally upregulated Neu-associated kinase

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of HUNK mRNA]

NCBI chr11:29,641,122...29,758,392
Ensembl chr11:29,640,775...29,757,526

G

islet cell autoantigen 1-like

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ICA1L mRNA]

NCBI chr 9:61,410,959...61,469,884
Ensembl chr 9:61,412,091...61,470,134

G

intercellular adhesion molecule 5

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ICAM5 mRNA]

NCBI chr 8:19,567,390...19,575,588
Ensembl chr 8:19,568,600...19,575,588

G

interferon-induced protein 44

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of IFI44 mRNA]

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844

G

interleukin 1 beta

multiple interactions

fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]

PMID:22735499 PMID:35616142

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 23 receptor

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of IL23R mRNA]

NCBI chr 4:96,580,568...96,672,540
Ensembl chr 4:96,580,714...96,674,021

G

interleukin 24

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of IL24 mRNA]

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

interleukin 6

multiple interactions

fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]
fucoxanthin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]

PMID:22735499 PMID:35616142 PMID:38444163

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inositol 1,4,5-triphosphate receptor associated 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of IRAG1 mRNA]

NCBI chr 1:164,981,716...165,094,232
Ensembl chr 1:164,981,716...165,094,176

G

interferon regulatory factor 7

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of IRF7 mRNA]

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

Janus kinase 2

decreases phosphorylation

fucoxanthin results in decreased phosphorylation of JAK2 protein

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

potassium voltage-gated channel interacting protein 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of KCNIP2 mRNA]; fucoxanthin inhibits the reaction [Glucose results in increased methylation of KCNIP2 gene]

NCBI chr 1:244,641,147...244,664,939
Ensembl chr 1:244,641,150...244,664,874

G

lysophosphatidylcholine acyltransferase 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of LPCAT1 mRNA]

NCBI chr 1:29,766,070...29,816,401
Ensembl chr 1:29,766,071...29,816,401

G

leucine rich repeat containing 61

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of LRRC61 mRNA]

NCBI chr 4:77,503,882...77,523,909
Ensembl chr 4:77,503,857...77,524,020

G

leukotriene C4 synthase

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of LTC4S mRNA]

NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651

G

lymphocyte antigen 96

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of LY96 mRNA]

NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386

G

male germ cell-associated kinase

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of MAK mRNA]

NCBI chr17:23,683,753...23,731,125
Ensembl chr17:23,693,878...23,730,001

G

MAM domain containing 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of MAMDC2 mRNA]

NCBI chr 1:220,863,959...221,016,493
Ensembl chr 1:220,863,976...221,016,354

G

monoamine oxidase A

decreases activity

fucoxanthin results in decreased activity of MAOA protein

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

monoamine oxidase B

decreases activity

fucoxanthin results in decreased activity of MAOB protein

NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003

G

mitogen-activated protein kinase kinase kinase 13

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of MAP3K13 mRNA]

NCBI chr11:79,094,087...79,235,181
Ensembl chr11:79,097,247...79,235,181

G

mitogen activated protein kinase 1

multiple interactions

fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of MAPK1 protein]; fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]

PMID:26418808 PMID:35616142

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

fucoxanthin inhibits the reaction [Carrageenan results in increased phosphorylation of MAPK3 protein]; fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]

PMID:26418808 PMID:35616142

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

fucoxanthin results in decreased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

major facilitator superfamily domain containing 3

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of MFSD3 mRNA]

NCBI chr 7:108,419,644...108,423,469
Ensembl chr 7:108,421,350...108,423,461

G

mechanistic target of rapamycin kinase

decreases expression

fucoxanthin results in decreased expression of MTOR mRNA

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

myosin VIIb

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of MYO7B mRNA]

NCBI chr18:23,588,307...23,669,841
Ensembl chr18:23,588,307...23,669,809

G

NKD inhibitor of WNT signaling pathway 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of NKD2 mRNA]

NCBI chr 1:29,442,898...29,470,839
Ensembl chr 1:29,441,328...29,470,821

G

nitric oxide synthase 2

multiple interactions

fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; fucoxanthin inhibits the reaction [Carrageenan results in increased expression of NOS2 protein]

PMID:22735499 PMID:26418808

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor binding protein 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of NRBP2 mRNA]

NCBI chr 7:107,798,642...107,805,225
Ensembl chr 7:107,799,497...107,805,230

G

neurotrimin

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of NTM mRNA]

NCBI chr 8:27,376,582...28,366,604
Ensembl chr 8:27,377,773...28,366,595

G

neurexophilin and PC-esterase domain family member 4

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of NXPE4 mRNA]

NCBI chr 8:48,502,697...48,744,101
Ensembl chr 8:48,722,440...48,744,100

G

2'-5'-oligoadenylate synthetase 3

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of OAS3 mRNA]

NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781

G

protein kinase C and casein kinase substrate in neurons 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of PACSIN1 mRNA]

NCBI chr20:5,718,134...5,768,064
Ensembl chr20:5,719,857...5,765,313

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

BCL2L1 protein inhibits the reaction [fucoxanthin results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [fucoxanthin results in increased cleavage of PARP1 protein]; STAT3 protein inhibits the reaction [fucoxanthin results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

protocadherin 17

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of PCDH17 mRNA]

NCBI chr15:60,222,088...60,316,172
Ensembl chr15:60,222,004...60,313,999

G

phosphatidylinositol-4-phosphate 5-kinase type 1 beta

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased methylation of PIP5K1B gene]; fucoxanthin inhibits the reaction [Glucose results in increased expression of PIP5K1B mRNA]

NCBI chr 1:221,907,220...222,183,672
Ensembl chr 1:221,914,159...222,183,672

G

PITPNM family member 3

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of PITPNM3 mRNA]

NCBI chr10:56,674,697...56,766,552
Ensembl chr10:56,676,261...56,766,584

G

peroxisome proliferator activated receptor alpha

increases expression

fucoxanthin results in increased expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

decreases expression

fucoxanthin results in decreased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

presenilin 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of PSEN2 mRNA]

NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174

G

prostaglandin-endoperoxide synthase 2

multiple interactions

fucoxanthin analog affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; fucoxanthin analog affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; fucoxanthin inhibits the reaction [Carrageenan results in increased expression of PTGS2 protein]

PMID:22735499 PMID:26418808

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

prostaglandin-endoperoxide synthase 2, opposite strand

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of PTGS2OS mRNA]

NCBI chr13:62,160,002...62,163,710

G

Rab40b, member RAS oncogene family

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of RAB40B mRNA]

NCBI chr10:106,631,514...106,659,090
Ensembl chr10:106,631,514...106,659,090

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

resistin

decreases expression

fucoxanthin results in decreased expression of RETN protein

NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620

G

ras homolog family member A

multiple interactions

fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased activity of RHOA protein]

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

RIMS binding protein 3

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of RIMBP3 mRNA]

NCBI chr11:83,783,816...83,789,391
Ensembl chr11:83,784,244...83,789,082

G

receptor (chemosensory) transporter protein 4

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of RTP4 mRNA]

NCBI chr11:77,237,341...77,249,194
Ensembl chr11:77,238,216...77,335,437

G

SHC adaptor protein 4

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of SHC4 mRNA]

NCBI chr 3:112,880,598...112,974,216
Ensembl chr 3:112,880,600...112,974,366

G

solute carrier family 16 member 5

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of SLC16A5 mRNA]

NCBI chr10:100,707,434...100,721,338
Ensembl chr10:100,707,434...100,721,338

G

solute carrier family 18 member A2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of SLC18A2 mRNA]

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

G

solute carrier family 6 member 18

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of SLC6A18 mRNA]

NCBI chr 1:29,607,288...29,621,925
Ensembl chr 1:29,608,077...29,621,925

G

signal transducer and activator of transcription 3

multiple interactions
decreases phosphorylation

fucoxanthin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; STAT3 protein inhibits the reaction [fucoxanthin results in decreased expression of BCL2L1 protein]; STAT3 protein inhibits the reaction [fucoxanthin results in increased cleavage of PARP1 protein]
fucoxanthin results in decreased phosphorylation of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

striatin interacting protein 2

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of STRIP2 mRNA]

NCBI chr 4:58,536,034...58,578,279
Ensembl chr 4:58,536,055...58,578,291

G

synapsin I

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of SYN1 mRNA]

NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396

G

synaptopodin 2-like

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of SYNPO2L mRNA]

NCBI chr15:3,631,974...3,641,429
Ensembl chr15:3,631,834...3,641,429

G

transforming growth factor beta 1 induced transcript 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of TGFB1I1 mRNA]

NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080

G

thrombospondin type 1 domain containing 7A

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of THSD7A mRNA]

NCBI chr 4:40,461,124...40,899,345
Ensembl chr 4:40,460,814...40,899,583

G

transmembrane protein with EGF-like and two follistatin-like domains 1

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of TMEFF1 mRNA]; fucoxanthin inhibits the reaction [Glucose results in increased methylation of TMEFF1 gene]

NCBI chr 5:62,910,740...62,996,494
Ensembl chr 5:62,910,740...62,996,493

G

transmembrane protein 229B

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of TMEM229B mRNA]

NCBI chr 6:97,771,645...97,819,582
Ensembl chr 6:97,775,332...97,819,489

G

tumor necrosis factor

multiple interactions

fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; fucoxanthin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]

PMID:22735499 PMID:35616142

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 13

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of TNFSF13 mRNA]

NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042

G

tetratricopeptide repeat domain 21A

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of TTC21A mRNA]

NCBI chr 8:119,667,044...119,702,028
Ensembl chr 8:119,666,933...119,702,456

G

Wnt family member 7B

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of WNT7B mRNA]

NCBI chr 7:116,634,817...116,679,459
Ensembl chr 7:116,634,814...116,679,581

G

zinc finger protein 521

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ZFP521 mRNA]

NCBI chr18:4,775,952...5,068,592
Ensembl chr18:4,787,295...5,068,458

G

zinc finger protein 566

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in increased expression of ZFP566 mRNA]

NCBI chr 1:85,318,449...85,342,186
Ensembl chr 1:85,318,452...85,333,161

G

ZXD family zinc finger C

multiple interactions

fucoxanthin inhibits the reaction [Glucose results in decreased expression of ZXDA mRNA]

NCBI chr 4:122,882,389...122,914,486
Ensembl chr 4:122,882,336...122,916,496

lutein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alsin Rho guanine nucleotide exchange factor ALS2

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of ALS2 mRNA; [Cisplatin co-treated with Lutein] results in increased expression of ALS2 mRNA
Lutein results in decreased expression of ALS2 mRNA

NCBI chr 9:60,613,182...60,686,394
Ensembl chr 9:60,613,167...60,670,737

G

APC regulator of WNT signaling pathway

multiple interactions

[Cisplatin co-treated with Lutein] results in increased expression of APC mRNA

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

aquarius intron-binding spliceosomal factor

decreases expression
multiple interactions

Lutein results in decreased expression of AQR mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of AQR mRNA

NCBI chr 3:100,874,987...100,945,026
Ensembl chr 3:100,874,987...100,945,044

G

ATR serine/threonine kinase

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of ATR mRNA
Lutein results in decreased expression of ATR mRNA

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

BCL2 associated X, apoptosis regulator

increases expression

Lutein results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

Lutein results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression

Lutein results in increased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

beta-carotene oxygenase 2

increases metabolic processing
affects metabolic processing
multiple interactions

BCO2 protein results in increased metabolism of Lutein
BCO2 protein affects the metabolism of Lutein
[BCO2 protein affects the metabolism of Lutein] which results in increased abundance of 3'-dehydrolutein; [BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite

NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467

G

catalase

multiple interactions

Lutein inhibits the reaction [deoxynivalenol results in increased expression of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin D1

decreases expression

Lutein results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

copper chaperone for superoxide dismutase

increases expression

Lutein results in increased expression of CCS mRNA

NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915

G

complement factor D

decreases expression
decreases secretion

Lutein results in decreased expression of CFD mRNA
Lutein results in decreased secretion of CFD protein

NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053

G

creatine kinase B

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in increased activity of CKB protein]

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

cathepsin B

increases expression
multiple interactions

Lutein results in increased expression of CTSB mRNA
Cisplatin inhibits the reaction [Lutein results in increased expression of CTSB mRNA]

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cytochrome b-245 alpha chain

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of CYBA mRNA
Lutein results in decreased expression of CYBA mRNA

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

desmin

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in decreased expression of DES protein]

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

ERCC excision repair 2, TFIIH core complex helicase subunit

decreases expression
multiple interactions

Lutein results in decreased expression of ERCC2 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of ERCC2 mRNA

NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102

G

ERCC excision repair 6, chromatin remodeling factor

decreases expression

Lutein results in decreased expression of ERCC6 mRNA

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

flavin containing dimethylaniline monoxygenase 2

decreases expression

Lutein results in decreased expression of FMO2 mRNA

NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308

G

GRB2-associated binding protein 1

decreases expression
multiple interactions

Lutein results in decreased expression of GAB1 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of GAB1 mRNA

NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236

G

glutathione peroxidase 1

multiple interactions
increases expression

Cisplatin inhibits the reaction [Lutein results in increased expression of GPX1 mRNA]; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of GPX1 mRNA]

PMID:22040935 PMID:24865317

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

multiple interactions

[Lutein co-treated with Cisplatin] results in increased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 3

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of GPX3 mRNA

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutathione-disulfide reductase

increases expression
multiple interactions

Lutein results in increased expression of GSR mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase kappa 1

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

heme oxygenase 1

multiple interactions
increases expression

arsenic trioxide promotes the reaction [Lutein results in increased expression of HMOX1 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of HMOX1 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]
Lutein results in increased expression of HMOX1 mRNA; Lutein results in increased expression of HMOX1 protein

PMID:25815309 PMID:26187899

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

isocitrate dehydrogenase (NADP(+)) 1

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of IDH1 mRNA
Lutein results in decreased expression of IDH1 mRNA

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

intraflagellar transport 172

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of IFT172 mRNA
Lutein results in decreased expression of IFT172 mRNA

NCBI chr 6:25,081,933...25,121,271
Ensembl chr 6:25,081,980...25,120,860

G

insulin 1

multiple interactions
decreases expression

[Lutein co-treated with alpha-Tocopherol] results in decreased expression of INS1 protein; [Lutein co-treated with Ascorbic Acid] results in decreased expression of INS1 protein
Lutein results in decreased expression of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

kinesin family member 9

multiple interactions
increases expression

Lutein promotes the reaction [Cisplatin results in decreased expression of KIF9 mRNA]
Lutein results in increased expression of KIF9 mRNA

NCBI chr 8:110,459,467...110,504,492
Ensembl chr 8:110,459,383...110,505,252

G

myoglobin

increases expression

Lutein results in increased expression of MB mRNA

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

microsomal glutathione S-transferase 1

multiple interactions
increases expression

arsenic trioxide promotes the reaction [Lutein results in increased expression of MGST1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of MGST1 mRNA]

PMID:25815309 PMID:26187899

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

myocardial infarction associated transcript

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in increased expression of MIAT]

NCBI chr12:44,414,620...44,429,852

G

microRNA 200a

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in decreased expression of MIR200A mRNA]

NCBI chr 5:166,648,494...166,648,582

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

arsenic trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 protein]; Lutein results in increased expression of and affects the localization of NFE2L2 protein
Lutein inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 protein]
Lutein results in increased expression of NFE2L2 mRNA; Lutein results in increased expression of NFE2L2 protein

PMID:25815309 PMID:26187899 PMID:34435724

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

neuroglobin

increases expression

Lutein results in increased expression of NGB mRNA

NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830

G

NADPH oxidase 4

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of NOX4 mRNA
Lutein results in decreased expression of NOX4 mRNA

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

NADPH oxidase organizer 1

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of NOXO1 mRNA

NCBI chr10:13,723,253...13,726,008
Ensembl chr10:13,721,473...13,726,061

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

[Cisplatin co-treated with Lutein] results in increased expression of NQO1 mRNA; arsenic trioxide promotes the reaction [Lutein results in increased expression of NQO1 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of NQO1 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NQO1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NQO1 protein]
Lutein results in increased expression of NQO1 mRNA; Lutein results in increased expression of NQO1 protein

PMID:24865317 PMID:25815309 PMID:26187899

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nudix hydrolase 15

decreases expression
multiple interactions

Lutein results in decreased expression of NUDT15 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of NUDT15 mRNA

NCBI chr15:48,707,776...48,713,847
Ensembl chr15:48,709,700...48,747,363

G

nucleoredoxin

increases expression
multiple interactions

Lutein results in increased expression of NXN mRNA
Lutein inhibits the reaction [Cisplatin results in increased expression of NXN mRNA]

NCBI chr10:61,109,322...61,247,578
Ensembl chr10:61,110,020...61,248,251

G

Parkinsonism associated deglycase

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of PARK7 mRNA

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

protein phosphatase 1, regulatory subunit 15B

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of PPP1R15B mRNA
Lutein results in decreased expression of PPP1R15B mRNA

NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737

G

peroxiredoxin 4

increases expression

Lutein results in increased expression of PRDX4 mRNA

NCBI chr X:40,026,762...40,044,066
Ensembl chr X:40,026,651...40,044,066

G

peroxiredoxin 5

decreases expression

Lutein results in decreased expression of PRDX5 mRNA

NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268

G

peroxiredoxin 6

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of PRDX6 mRNA
Lutein results in decreased expression of PRDX6 mRNA

NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of PTGS1 mRNA

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Lutein inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Lutein inhibits the reaction [deoxynivalenol affects the localization of RELA protein]; Lutein inhibits the reaction [deoxynivalenol results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

stearoyl-CoA desaturase

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of SCD1 mRNA
Lutein results in decreased expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

superoxide dismutase 1

multiple interactions
increases expression

Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD1 mRNA]
Lutein results in increased expression of SOD1 mRNA

PMID:22040935 PMID:24865317

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of SOD2 mRNA; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD2 mRNA]
Lutein results in decreased expression of SOD2 mRNA

PMID:22040935 PMID:24865317

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of SOD3 mRNA
Lutein results in decreased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

sulfiredoxin 1

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of SRXN1 mRNA
Lutein results in decreased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

troponin T2, cardiac type

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in decreased expression of TNNT2 protein]

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

G

thioredoxin 1

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in decreased expression of TXN protein]

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin interacting protein

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in increased expression of TXNIP protein]

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

decreases expression
multiple interactions

Lutein results in decreased expression of TXNRD1 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

uncoupling protein 3

increases expression

Lutein results in increased expression of UCP3 mRNA

NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762

G

vimentin

increases expression

Lutein results in increased expression of VIM mRNA

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

xin actin-binding repeat containing 1

increases expression

Lutein results in increased expression of XIRP1 mRNA

NCBI chr 8:119,744,778...119,757,547
Ensembl chr 8:119,747,419...119,757,349

lycopene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

multiple interactions

Lycopene inhibits the reaction [bisphenol A results in decreased activity of ACE protein]

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acetylcholinesterase

multiple interactions

Lycopene inhibits the reaction [manganese chloride results in increased activity of ACHE protein]; Lycopene inhibits the reaction [Sodium Glutamate results in increased activity of ACHE protein]

PMID:22192907 PMID:26900785

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

adducin 1

decreases expression

lycopene results in decreased expression of ADD1 mRNA

NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182

G

advanced glycosylation end product-specific receptor

multiple interactions

lycopene inhibits the reaction [HMGB1 protein results in increased expression of AGER protein]; lycopene inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

aryl hydrocarbon receptor

decreases expression
multiple interactions

lycopene results in decreased expression of AHR mRNA
[Lycopene co-treated with Atrazine] results in increased expression of AHR mRNA; Lycopene inhibits the reaction [Atrazine results in increased expression of AHR protein]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of AHR mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of and results in increased localization of AHR protein]

PMID:16886892 PMID:36216167 PMID:36403809

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

allograft inflammatory factor 1

multiple interactions

lycopene inhibits the reaction [Galactose results in increased expression of AIF1 protein]

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

AKT serine/threonine kinase 1

decreases phosphorylation

lycopene results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aminolevulinate dehydratase

multiple interactions

lycopene inhibits the reaction [Zearalenone results in decreased activity of ALAD protein]
lycopene inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]

PMID:17516994 PMID:25682699

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

androgen regulated protein

decreases expression

lycopene results in decreased expression of ANDPRO mRNA

NCBI chr 3:136,718,601...136,725,131
Ensembl chr 3:136,718,602...136,724,966

G

aquaporin 1

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of AQP1 mRNA]

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

aquaporin 11

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of AQP11 mRNA]

NCBI chr 1:152,046,515...152,056,675
Ensembl chr 1:152,046,517...152,056,725

G

aquaporin 2

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of AQP2 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of AQP2 protein]

NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468

G

aquaporin 4

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of AQP4 mRNA]

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

aquaporin 6

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of AQP6 mRNA]

NCBI chr 7:130,732,216...130,735,149
Ensembl chr 7:130,633,579...130,735,194
Ensembl chr 7:130,633,579...130,735,194

G

aquaporin 7

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of AQP7 mRNA]

NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642

G

androgen receptor

decreases expression

lycopene results in decreased expression of AR mRNA

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

aryl hydrocarbon receptor nuclear translocator

increases expression
multiple interactions

Lycopene results in increased expression of ARNT mRNA
Lycopene inhibits the reaction [Atrazine results in increased expression of ARNT mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ARNT mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ARNT protein]

PMID:36216167 PMID:36403809

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

activating transcription factor 6

multiple interactions

Lycopene inhibits the reaction [Oxaliplatin results in increased expression of ATF6 mRNA]

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

autophagy related 10

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG10 mRNA]

NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233

G

autophagy related 13

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG13 mRNA]

NCBI chr 3:77,647,069...77,681,028
Ensembl chr 3:77,645,790...77,681,043

G

autophagy related 14

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG14 mRNA]

NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113

G

autophagy related 16-like 1

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG16L1 mRNA]

NCBI chr 9:88,420,737...88,457,530
Ensembl chr 9:88,422,038...88,457,529

G

autophagy related 16-like 2

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG16L2 mRNA]

NCBI chr 1:155,687,386...155,703,419
Ensembl chr 1:155,684,564...155,703,420

G

autophagy related 2B

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG2B mRNA]

NCBI chr 6:124,522,283...124,592,412
Ensembl chr 6:124,525,523...124,592,015

G

autophagy related 3

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG3 mRNA]

NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224

G

autophagy related 4A, cysteine peptidase

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG4A mRNA]

NCBI chr X:104,665,345...104,765,271
Ensembl chr X:104,665,345...104,765,268

G

autophagy related 4B, cysteine peptidase

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG4B mRNA]

NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103

G

autophagy related 4C, cysteine peptidase

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG4C mRNA]

NCBI chr 5:113,867,218...113,935,534
Ensembl chr 5:113,867,092...113,934,830

G

autophagy related 5

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG5 mRNA]
[Glucose co-treated with Lycopene] results in increased expression of ATG5 mRNA

PMID:30360616 PMID:38444079

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

autophagy related 7

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG7 mRNA]

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

G

autophagy related 9A

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG9A mRNA]

NCBI chr 9:76,677,403...76,688,050
Ensembl chr 9:76,677,404...76,687,986

G

autophagy related 9B

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of ATG9B mRNA]

NCBI chr 4:10,784,934...10,793,832
Ensembl chr 4:10,786,114...10,793,651

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP1A1 mRNA]; Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1A1 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of ATP1A1 mRNA]

PMID:26476475 PMID:27112537 PMID:33960999

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATPase Na+/K+ transporting subunit alpha 2

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1A2 mRNA]

PMID:27112537 PMID:33960999

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATPase Na+/K+ transporting subunit alpha 3

multiple interactions

lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1A3 mRNA]

NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918

G

ATPase Na+/K+ transporting subunit alpha 4

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP1A4 mRNA]

PMID:26476475 PMID:27112537

NCBI chr13:84,683,766...84,719,790
Ensembl chr13:84,683,768...84,719,687

G

ATPase Na+/K+ transporting subunit beta 1

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1B1 mRNA]

PMID:27112537 PMID:33960999

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

ATPase Na+/K+ transporting subunit beta 2

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP1B2 mRNA]; Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1B2 mRNA]

PMID:26476475 PMID:27112537 PMID:33960999

NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933

G

ATPase Na+/K+ transporting subunit beta 3

multiple interactions

lycopene inhibits the reaction [Atrazine affects the expression of ATP1B3 mRNA]

NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598

G

ATPase Na+/K+ transporting family member beta 4

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1B4 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of ATP1B4 mRNA]

PMID:26476475 PMID:33960999

NCBI chr X:117,087,284...117,108,023
Ensembl chr X:117,057,423...117,108,020

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP2A1 mRNA]

NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP2A2 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of ATP2A2 mRNA]

PMID:27112537 PMID:33960999

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2A3 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of ATP2A3 mRNA]

PMID:26476475 PMID:27112537 PMID:33960999

NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748

G

ATPase plasma membrane Ca2+ transporting 1

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP2B1 mRNA]; Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2B1 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of ATP2B1 mRNA]

PMID:26476475 PMID:27112537 PMID:33960999

NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295

G

ATPase plasma membrane Ca2+ transporting 2

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2B2 mRNA]

PMID:26476475 PMID:27112537

NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665

G

ATPase plasma membrane Ca2+ transporting 3

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2B3 mRNA]

PMID:26476475 PMID:27112537

NCBI chr X:151,216,483...151,289,069
Ensembl chr X:151,216,507...151,286,775

G

ATPase plasma membrane Ca2+ transporting 4

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP2B4 mRNA]

PMID:26476475 PMID:27112537

NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246

G

ATPase secretory pathway Ca2+ transporting 1

multiple interactions

Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2C1 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of ATP2C1 mRNA]

PMID:26476475 PMID:27112537 PMID:33960999

NCBI chr 8:106,034,777...106,155,854
Ensembl chr 8:106,034,636...106,156,006

G

ATPase secretory pathway Ca2+ transporting 2

multiple interactions

Lycopene inhibits the reaction [Atrazine affects the expression of ATP2C2 mRNA]; Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2C2 mRNA]

PMID:26476475 PMID:27112537 PMID:33960999

NCBI chr19:47,754,120...47,811,369
Ensembl chr19:47,754,120...47,811,368

G

BTB domain and CNC homolog 1

increases expression

lycopene results in increased expression of BACH1 mRNA

NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447

G

BCL2-antagonist/killer 1

multiple interactions

Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAK1 protein]

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BRCA1 associated deubiquitinase 1

increases expression

lycopene results in increased expression of BAP1 mRNA

NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535

G

BCL2 associated X, apoptosis regulator

multiple interactions

Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]; Lycopene inhibits the reaction [Sodium Fluoride results in increased expression of BAX mRNA]
Lycopene inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]; Lycopene inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Sodium Fluoride results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Sodium Glutamate results in increased expression of BAX mRNA]

PMID:26900785 PMID:27871895 PMID:31568845 PMID:32153214 PMID:36583613

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

multiple interactions

Lycopene inhibits the reaction [Sodium Glutamate results in increased activity of BCHE protein]

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

multiple interactions
increases expression

[Glucose co-treated with Lycopene] results in increased expression of BCL2 mRNA; [S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; Lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; Lycopene inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 mRNA]; Lycopene inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]; Lycopene inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Lycopene inhibits the reaction [Sodium Fluoride results in decreased expression of BCL2 mRNA]; Lycopene inhibits the reaction [Sodium Glutamate results in decreased expression of BCL2 mRNA]
Lycopene results in increased expression of BCL2 mRNA
lycopene inhibits the reaction [Sodium Fluoride results in decreased expression of BCL2 mRNA]

PMID:16030430 PMID:26900785 PMID:27871895 PMID:31568845 PMID:32153214 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

beta-carotene oxygenase 1

multiple interactions

BCO1 affects the reaction [lycopene results in decreased abundance of Testosterone]

NCBI chr19:45,149,250...45,186,102
Ensembl chr19:45,149,265...45,186,101

G

brain-derived neurotrophic factor

multiple interactions

Lycopene inhibits the reaction [Galactose results in decreased expression of BDNF mRNA]; Lycopene inhibits the reaction [Galactose results in decreased expression of BDNF protein]
Lycopene inhibits the reaction [bisphenol A results in decreased expression of BDNF protein]; Lycopene inhibits the reaction [Oxaliplatin results in decreased expression of BDNF protein]

PMID:28974442 PMID:32153214 PMID:32544411

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

multiple interactions

Lycopene inhibits the reaction [Atrazine results in increased expression of BECN1 mRNA]
[Glucose co-treated with Lycopene] results in increased expression of BECN1 mRNA

PMID:30360616 PMID:38444079

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

B-Raf proto-oncogene, serine/threonine kinase

decreases expression

lycopene results in decreased expression of BRAF protein

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

complement C1q A chain

decreases expression

lycopene results in decreased expression of C1QA mRNA

NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534

G

complement C4B

decreases expression

lycopene results in decreased expression of C4B mRNA

NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681

G

calcitonin-related polypeptide alpha

multiple interactions

Lycopene inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of CALCA protein]

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

caspase 1

multiple interactions

Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CASP1 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions

[Glucose co-treated with Lycopene] results in increased expression of CASP3 mRNA; [S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein]; Lycopene inhibits the reaction [Atrazine results in increased expression of CASP3 mRNA]; Lycopene inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]; Lycopene inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; Lycopene inhibits the reaction [Oxaliplatin results in increased expression of CASP3 protein]; Lycopene inhibits the reaction [Sodium Fluoride results in increased activity of CASP3 protein]; Lycopene inhibits the reaction [Sodium Fluoride results in increased expression of CASP3 mRNA]
Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CASP3 protein]; Lycopene inhibits the reaction [Sodium Fluoride results in increased activity of CASP3 protein]; Lycopene inhibits the reaction [Sodium Fluoride results in increased expression of CASP3 mRNA]

PMID:16030430 PMID:27102619 PMID:27871895 PMID:31568845 PMID:32153214 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions
decreases expression

[Glucose co-treated with Lycopene] results in increased expression of CASP8 mRNA; [S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; Lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]
lycopene results in decreased expression of CASP8 mRNA

PMID:16030430 PMID:16886892 PMID:38444079

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

[Glucose co-treated with Lycopene] results in increased expression of CASP9 mRNA; Lycopene inhibits the reaction [Sodium Fluoride results in increased expression of CASP9 mRNA]
lycopene inhibits the reaction [Sodium Fluoride results in increased activity of CASP9 protein]; lycopene inhibits the reaction [Sodium Fluoride results in increased expression of CASP9 mRNA]

PMID:27871895 PMID:38444079

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases expression
increases activity
increases expression

Lycopene affects the reaction [Doxorubicin affects the activity of CAT protein]; Lycopene inhibits the reaction [Atrazine results in decreased activity of CAT protein]; Lycopene inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; Lycopene inhibits the reaction [Cadmium Chloride results in increased activity of CAT protein]; Lycopene inhibits the reaction [Mercuric Chloride results in increased activity of CAT protein]; Lycopene inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein]; Lycopene inhibits the reaction [Sodium Glutamate results in increased activity of CAT protein]; Lycopene inhibits the reaction [Sodium Glutamate results in increased expression of CAT mRNA]
Lycopene results in decreased expression of CAT mRNA
Lycopene affects the reaction [Atrazine affects the expression of CAT mRNA]; Lycopene inhibits the reaction [Acetaminophen results in increased activity of CAT protein]; Lycopene inhibits the reaction [Atrazine results in decreased activity of CAT protein]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CAT mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CAT protein]
lycopene results in increased activity of CAT protein
lycopene results in increased expression of CAT

PMID:16325981 PMID:17516994 PMID:17873360 PMID:19450652 PMID:20074268 More...