Trem2 (triggering receptor expressed on myeloid cells 2) - Rat Genome Database

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Gene: Trem2 (triggering receptor expressed on myeloid cells 2) Rattus norvegicus
Analyze
Symbol: Trem2
Name: triggering receptor expressed on myeloid cells 2
RGD ID: 1309841
Description: Predicted to enable several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Involved in cellular response to glucose stimulus and cellular response to hypoxia. Predicted to be located in plasma membrane raft. Predicted to be active in cell surface and plasma membrane. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC301227; Trem2-Mia; Trem2-Mib
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,145,215 - 20,151,797 (-)NCBIGRCr8
mRatBN7.2912,647,605 - 12,654,190 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,647,259 - 12,654,170 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx921,160,724 - 21,167,248 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,226,948 - 26,233,472 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0924,616,230 - 24,622,771 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0914,611,541 - 14,618,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,611,561 - 14,618,013 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0913,532,905 - 13,539,382 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,059,023 - 8,065,585 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.198,059,020 - 8,065,484 (-)NCBI
Celera910,419,918 - 10,426,480 (-)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
astaxanthin  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP,ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
genistein  (EXP)
glucose  (ISO)
Harpagide  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methamphetamine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
quartz  (EXP)
quercetin  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
Soman  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (ISO)
amyloid-beta clearance by cellular catabolic process  (ISO)
apoptotic cell clearance  (ISO)
astrocyte activation  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to glucose stimulus  (IMP)
cellular response to hypoxia  (IMP)
cellular response to lipid  (ISO)
cellular response to lipoteichoic acid  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (ISO)
cellular response to peptidoglycan  (ISO)
complement-mediated synapse pruning  (ISO)
CXCL12-activated CXCR4 signaling pathway  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-negative bacterium  (ISO)
dendritic cell differentiation  (ISO)
dendritic spine maintenance  (ISO)
detection of lipopolysaccharide  (ISO)
detection of lipoteichoic acid  (ISO)
detection of peptidoglycan  (ISO)
excitatory synapse pruning  (ISO)
import into cell  (ISO)
lipid homeostasis  (ISO)
memory  (ISO)
microglial cell activation  (ISO)
microglial cell activation involved in immune response  (ISO)
microglial cell proliferation  (ISO)
negative regulation of amyloid fibril formation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of astrocyte activation  (ISO)
negative regulation of autophagic cell death  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cell activation  (ISO)
negative regulation of cholesterol storage  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of fat cell proliferation  (ISO)
negative regulation of glial cell apoptotic process  (ISO)
negative regulation of inflammatory response to antigenic stimulus  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of macrophage colony-stimulating factor signaling pathway  (ISO)
negative regulation of neuroinflammatory response  (ISO)
negative regulation of NLRP3 inflammasome complex assembly  (ISO)
negative regulation of p38MAPK cascade  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of sequestering of triglyceride  (ISO)
negative regulation of toll-like receptor 2 signaling pathway  (ISO)
negative regulation of toll-like receptor 4 signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
neuroinflammatory response  (ISO)
osteoclast differentiation  (ISO)
phagocytosis, engulfment  (ISO)
phagocytosis, recognition  (ISO)
positive regulation of amyloid-beta clearance  (ISO)
positive regulation of antigen processing and presentation of peptide antigen via MHC class II  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of C-C chemokine receptor CCR7 signaling pathway  (ISO)
positive regulation of calcium-mediated signaling  (IBA,ISO)
positive regulation of CAMKK-AMPK signaling cascade  (ISO)
positive regulation of CD40 signaling pathway  (ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of complement activation, classical pathway  (ISO)
positive regulation of engulfment of apoptotic cell  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,ISO)
positive regulation of establishment of protein localization  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of high-density lipoprotein particle clearance  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of low-density lipoprotein particle clearance  (ISO)
positive regulation of macrophage fusion  (ISO)
positive regulation of microglial cell activation  (IBA,ISO)
positive regulation of microglial cell migration  (ISO)
positive regulation of neuroinflammatory response  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of phagocytosis, engulfment  (IBA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of proteasomal protein catabolic process  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of synapse pruning  (ISO)
positive regulation of TOR signaling  (ISO)
pyroptosis  (ISO)
regulation of cytokine production involved in inflammatory response  (ISO)
regulation of gene expression  (ISO)
regulation of hippocampal neuron apoptotic process  (ISO)
regulation of innate immune response  (ISO)
regulation of interleukin-6 production  (ISO)
regulation of intracellular signal transduction  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of macrophage inflammatory protein 1 alpha production  (ISO)
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (IBA,ISO)
regulation of plasma membrane bounded cell projection organization  (IBA,ISO)
regulation of resting membrane potential  (ISO)
regulation of toll-like receptor 6 signaling pathway  (ISO)
regulation of TOR signaling  (ISO)
respiratory burst after phagocytosis  (ISO)
response to axon injury  (ISO)
response to ischemia  (ISO)
social behavior  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Increased CSF Soluble TREM2 Concentration in Patients With Neurosyphilis. Li W, etal., Front Neurol. 2020 Feb 5;11:62. doi: 10.3389/fneur.2020.00062. eCollection 2020.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus. Zhang J, etal., J Neuroinflammation. 2020 Jan 3;17(1):2. doi: 10.1186/s12974-019-1688-9.
Additional References at PubMed
PMID:11602640   PMID:12847223   PMID:12925681   PMID:15728241   PMID:16418779   PMID:18957693   PMID:19079182   PMID:19155473   PMID:21841309   PMID:24990881   PMID:25631124   PMID:26949937  
PMID:27044754   PMID:27477018   PMID:27589997   PMID:27662313   PMID:27995897   PMID:28483841   PMID:28547529   PMID:28592261   PMID:28802038   PMID:28849042   PMID:28855300   PMID:28855301  
PMID:29073081   PMID:29518356   PMID:29859094   PMID:30149915   PMID:30232263   PMID:30548312   PMID:32139718   PMID:32757264   PMID:33222683   PMID:36829205   PMID:37658943   PMID:38409127  


Genomics

Comparative Map Data
Trem2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,145,215 - 20,151,797 (-)NCBIGRCr8
mRatBN7.2912,647,605 - 12,654,190 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,647,259 - 12,654,170 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx921,160,724 - 21,167,248 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,226,948 - 26,233,472 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0924,616,230 - 24,622,771 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0914,611,541 - 14,618,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,611,561 - 14,618,013 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0913,532,905 - 13,539,382 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,059,023 - 8,065,585 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.198,059,020 - 8,065,484 (-)NCBI
Celera910,419,918 - 10,426,480 (-)NCBICelera
Cytogenetic Map9q12NCBI
TREM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,158,508 - 41,163,116 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,158,506 - 41,163,186 (-)EnsemblGRCh38hg38GRCh38
GRCh37641,126,246 - 41,130,854 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,234,230 - 41,238,892 (-)NCBINCBI36Build 36hg18NCBI36
Build 34641,234,230 - 41,238,892NCBI
Celera642,678,948 - 42,683,624 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef640,844,044 - 40,848,724 (-)NCBIHuRef
CHM1_1641,129,139 - 41,133,819 (-)NCBICHM1_1
T2T-CHM13v2.0640,987,077 - 40,991,685 (-)NCBIT2T-CHM13v2.0
Trem2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,653,429 - 48,659,304 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1748,653,429 - 48,661,175 (+)EnsemblGRCm39 Ensembl
GRCm381748,346,401 - 48,352,276 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,346,401 - 48,354,147 (+)EnsemblGRCm38mm10GRCm38
MGSCv371748,485,726 - 48,491,598 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361747,811,968 - 47,817,840 (+)NCBIMGSCv36mm8
Celera1751,775,275 - 51,781,147 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.99NCBI
Trem2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554377,780,679 - 7,785,697 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554377,780,886 - 7,785,597 (-)NCBIChiLan1.0ChiLan1.0
TREM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2555,643,268 - 55,647,978 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1651,513,212 - 51,517,926 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0640,735,483 - 40,740,208 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,043,887 - 42,048,578 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,043,900 - 42,048,578 (-)Ensemblpanpan1.1panPan2
Trem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,295,126 - 45,300,504 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647618,659,815 - 18,663,940 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647618,659,725 - 18,665,406 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TREM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,465,324 - 36,471,516 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1736,465,921 - 36,471,509 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2741,763,412 - 41,767,191 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TREM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,965,091 - 30,999,073 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1730,994,357 - 30,999,087 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604441,158,611 - 41,163,469 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trem2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475417,643,363 - 17,648,231 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475417,643,397 - 17,649,255 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Trem2
100 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:38
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000018351
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9336865213533896Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 5 8
Low 2 33 13 3 8 3 6 8 60 33 28 3 6
Below cutoff 1 4 38 32 11 32 2 3 4 2 6 2

Sequence


RefSeq Acc Id: ENSRNOT00000018351   ⟹   ENSRNOP00000018351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl912,647,608 - 12,654,170 (-)Ensembl
Rnor_6.0 Ensembl914,611,561 - 14,618,013 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093814   ⟹   ENSRNOP00000077250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl912,647,259 - 12,654,170 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112464   ⟹   ENSRNOP00000087941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl912,647,887 - 12,651,892 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114012   ⟹   ENSRNOP00000086823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl912,647,606 - 12,654,170 (-)Ensembl
RefSeq Acc Id: NM_001106884   ⟹   NP_001100354
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,145,217 - 20,151,779 (-)NCBI
mRatBN7.2912,647,608 - 12,654,170 (-)NCBI
Rnor_6.0914,611,561 - 14,618,013 (-)NCBI
Rnor_5.0913,532,905 - 13,539,382 (-)NCBI
RGSC_v3.498,059,023 - 8,065,585 (-)RGD
Celera910,419,918 - 10,426,480 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244425   ⟹   XP_006244487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,145,215 - 20,151,797 (-)NCBI
mRatBN7.2912,647,606 - 12,654,189 (-)NCBI
Rnor_6.0914,611,559 - 14,618,073 (-)NCBI
Rnor_5.0913,532,905 - 13,539,382 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063266844   ⟹   XP_063122914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,145,215 - 20,151,796 (-)NCBI
RefSeq Acc Id: NP_001100354   ⟸   NM_001106884
- Peptide Label: precursor
- UniProtKB: D3ZZ89 (UniProtKB/TrEMBL),   A6JIF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244487   ⟸   XM_006244425
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y9E9 (UniProtKB/TrEMBL),   A6JIF4 (UniProtKB/TrEMBL),   A0A6G8MVL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018351   ⟸   ENSRNOT00000018351
RefSeq Acc Id: ENSRNOP00000086823   ⟸   ENSRNOT00000114012
RefSeq Acc Id: ENSRNOP00000077250   ⟸   ENSRNOT00000093814
RefSeq Acc Id: ENSRNOP00000087941   ⟸   ENSRNOT00000112464
RefSeq Acc Id: XP_063122914   ⟸   XM_063266844
- Peptide Label: isoform X1
Protein Domains
Ig-like   Immunoglobulin subtype

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZ89-F1-model_v2 AlphaFold D3ZZ89 1-228 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309841 AgrOrtholog
BioCyc Gene G2FUF-28307 BioCyc
Ensembl Genes ENSRNOG00000013578 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018351 ENTREZGENE
  ENSRNOT00000018351.6 UniProtKB/TrEMBL
  ENSRNOT00000093814.1 UniProtKB/TrEMBL
  ENSRNOT00000112464.1 UniProtKB/TrEMBL
  ENSRNOT00000114012.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
KEGG Report rno:301227 UniProtKB/TrEMBL
NCBI Gene 301227 ENTREZGENE
PANTHER IG-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  TREM-LIKE TRANSCRIPT PROTEIN UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Trem2 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013578 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A6G8MV71_RAT UniProtKB/TrEMBL
  A0A6G8MVL9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y9E9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A303_RAT UniProtKB/TrEMBL
  A0A8I6A9R5_RAT UniProtKB/TrEMBL
  A6JIF4 ENTREZGENE, UniProtKB/TrEMBL
  A6JIF6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZ89 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Trem2  triggering receptor expressed on myeloid cells 2   Trem2_predicted  triggering receptor expressed on myeloid cells 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Trem2_predicted  triggering receptor expressed on myeloid cells 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED