Trem2 (triggering receptor expressed on myeloid cells 2)

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Gene: Trem2 (triggering receptor expressed on myeloid cells 2) Rattus norvegicus

Analyze

Symbol:

Trem2

Name:

triggering receptor expressed on myeloid cells 2

RGD ID:

1309841

Description:

Predicted to enable several functions, including amyloid-beta binding activity; lipoprotein particle binding activity; and phospholipid binding activity. Involved in cellular response to glucose stimulus and cellular response to hypoxia. Predicted to be located in plasma membrane raft. Predicted to be active in cell surface and plasma membrane. Orthologous to human TREM2 (triggering receptor expressed on myeloid cells 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC301227; Trem2-Mia; Trem2-Mib

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	12,647,605 - 12,654,190 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	12,647,259 - 12,654,170 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	21,160,724 - 21,167,248 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	9	26,226,948 - 26,233,472 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	9	24,616,230 - 24,622,771 (-)	NCBI	Rnor_WKY
Rnor_6.0	9	14,611,541 - 14,618,076 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	14,611,561 - 14,618,013 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	13,532,905 - 13,539,382 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	8,059,023 - 8,065,585 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	8,059,020 - 8,065,484 (-)	NCBI
Celera	9	10,419,918 - 10,426,480 (-)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

dementia (ISO)

frontotemporal dementia (ISO,ISS)

genetic disease (ISO)

infantile Refsum disease (ISO)

Nasu-Hakola disease (ISO)

Neurosyphilis (ISO)

Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy 2 (ISO)

syphilis (ISO)

Zellweger syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

amphetamine (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

astaxanthin (ISO)

benzalkonium chloride (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

Benzo[ghi]perylene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

carbon nanotube (EXP,ISO)

CGP 52608 (ISO)

chlordecone (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

decabromodiphenyl ether (EXP)

endosulfan (EXP)

ethanol (ISO)

folic acid (ISO)

furan (EXP)

genistein (EXP)

ketamine (EXP)

L-methionine (ISO)

lipopolysaccharide (ISO)

menadione (ISO)

methamphetamine (EXP,ISO)

N-nitrosodiethylamine (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

quartz (EXP)

quercetin (ISO)

silicon dioxide (EXP,ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (EXP)

Soman (EXP)

tamoxifen (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amyloid-beta clearance (ISO)

amyloid-beta clearance by cellular catabolic process (ISO)

apoptotic cell clearance (ISO)

astrocyte activation (ISO)

cellular response to amyloid-beta (ISO)

cellular response to glucose stimulus (IMP)

cellular response to hypoxia (IMP)

cellular response to lipid (ISO)

cellular response to lipoteichoic acid (ISO)

cellular response to oxidised low-density lipoprotein particle stimulus (ISO)

cellular response to peptidoglycan (ISO)

complement-mediated synapse pruning (ISO)

CXCL12-activated CXCR4 signaling pathway (ISO)

defense response to bacterium (ISO)

defense response to Gram-negative bacterium (ISO)

dendritic cell differentiation (ISO)

dendritic spine maintenance (ISO)

detection of lipopolysaccharide (ISO)

detection of lipoteichoic acid (ISO)

detection of peptidoglycan (ISO)

excitatory synapse pruning (ISO)

import into cell (ISO)

lipid homeostasis (ISO)

memory (ISO)

microglial cell activation (ISO)

microglial cell activation involved in immune response (ISO)

microglial cell proliferation (ISO)

negative regulation of amyloid fibril formation (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of astrocyte activation (ISO)

negative regulation of autophagic cell death (ISO)

negative regulation of autophagy (ISO)

negative regulation of cell activation (ISO)

negative regulation of cholesterol storage (ISO)

negative regulation of cytokine production involved in inflammatory response (ISO)

negative regulation of fat cell proliferation (ISO)

negative regulation of glial cell apoptotic process (ISO)

negative regulation of I-kappaB kinase/NF-kappaB signaling (ISO)

negative regulation of inflammatory response to antigenic stimulus (ISO)

negative regulation of interleukin-1 beta production (ISO)

negative regulation of macrophage colony-stimulating factor signaling pathway (ISO)

negative regulation of neuroinflammatory response (ISO)

negative regulation of NLRP3 inflammasome complex assembly (ISO)

negative regulation of p38MAPK cascade (ISO)

negative regulation of phosphatidylinositol 3-kinase signaling (ISO)

negative regulation of sequestering of triglyceride (ISO)

negative regulation of toll-like receptor 2 signaling pathway (ISO)

negative regulation of toll-like receptor 4 signaling pathway (ISO)

negative regulation of tumor necrosis factor production (ISO)

neuroinflammatory response (ISO)

osteoclast differentiation (ISO)

phagocytosis, engulfment (ISO)

phagocytosis, recognition (ISO)

positive regulation of amyloid-beta clearance (ISO)

positive regulation of antigen processing and presentation of peptide antigen via MHC class II (ISO)

positive regulation of ATP biosynthetic process (ISO)

positive regulation of C-C chemokine receptor CCR7 signaling pathway (ISO)

positive regulation of calcium-mediated signaling (IBA,ISO)

positive regulation of CAMKK-AMPK signaling cascade (ISO)

positive regulation of CD40 signaling pathway (ISO)

positive regulation of chemotaxis (ISO)

positive regulation of cholesterol efflux (ISO)

positive regulation of complement activation, classical pathway (ISO)

positive regulation of engulfment of apoptotic cell (ISO)

positive regulation of ERK1 and ERK2 cascade (IBA,ISO)

positive regulation of establishment of protein localization (ISO)

positive regulation of gene expression (ISO)

positive regulation of high-density lipoprotein particle clearance (ISO)

positive regulation of interleukin-10 production (ISO)

positive regulation of inward rectifier potassium channel activity (ISO)

positive regulation of kinase activity (ISO)

positive regulation of low-density lipoprotein particle clearance (ISO)

positive regulation of macrophage fusion (ISO)

positive regulation of microglial cell activation (IBA,ISO)

positive regulation of microglial cell migration (ISO)

positive regulation of mitochondrion organization (ISO)

positive regulation of neuroinflammatory response (ISO)

positive regulation of NIK/NF-kappaB signaling (ISO)

positive regulation of osteoclast differentiation (ISO)

positive regulation of peptidyl-tyrosine phosphorylation (ISO)

positive regulation of phagocytosis (ISO)

positive regulation of phagocytosis, engulfment (IBA,ISO)

positive regulation of phosphatidylinositol 3-kinase signaling (ISO)

positive regulation of proteasomal protein catabolic process (ISO)

positive regulation of protein localization to plasma membrane (ISO)

positive regulation of protein phosphorylation (ISO)

positive regulation of protein secretion (ISO)

positive regulation of synapse pruning (ISO)

positive regulation of TOR signaling (ISO)

pyroptosis (ISO)

regulation of cytokine production involved in inflammatory response (ISO)

regulation of gene expression (ISO)

regulation of hippocampal neuron apoptotic process (ISO)

regulation of innate immune response (ISO)

regulation of interleukin-6 production (ISO)

regulation of intracellular signal transduction (ISO)

regulation of lipid metabolic process (ISO)

regulation of macrophage inflammatory protein 1 alpha production (ISO)

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (ISO)

regulation of peptidyl-tyrosine phosphorylation (IBA,ISO)

regulation of plasma membrane bounded cell projection organization (IBA,ISO)

regulation of resting membrane potential (ISO)

regulation of toll-like receptor 6 signaling pathway (ISO)

regulation of TOR signaling (ISO)

respiratory burst after phagocytosis (ISO)

response to axon injury (ISO)

response to ischemia (ISO)

social behavior (ISO)

Cellular Component

cell surface (ISO)

membrane (ISO)

plasma membrane (IBA,ISO)

plasma membrane raft (ISO)

Molecular Function

amyloid-beta binding (ISO)

apolipoprotein A-I binding (ISO)

apolipoprotein binding (ISO)

high-density lipoprotein particle binding (ISO)

kinase activator activity (ISO)

lipopolysaccharide binding (ISO)

lipoprotein particle binding (ISO)

lipoteichoic acid binding (ISO)

low-density lipoprotein particle binding (ISO)

molecular function activator activity (ISO)

peptidoglycan binding (ISO)

phosphatidylethanolamine binding (ISO)

phosphatidylserine binding (ISO)

phospholipid binding (ISO)

protein binding (ISO)

protein tyrosine kinase binding (ISO)

protein-containing complex binding (ISO)

scaffold protein binding (ISO)

signaling receptor activity (ISO)

sulfatide binding (ISO)

transmembrane signaling receptor activity (IBA,ISO)

very-low-density lipoprotein particle binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Increased CSF Soluble TREM2 Concentration in Patients With Neurosyphilis.	Li W, etal., Front Neurol. 2020 Feb 5;11:62. doi: 10.3389/fneur.2020.00062. eCollection 2020.
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus.	Zhang J, etal., J Neuroinflammation. 2020 Jan 3;17(1):2. doi: 10.1186/s12974-019-1688-9.

Additional References at PubMed

PMID:11602640	PMID:12847223	PMID:12925681	PMID:15728241	PMID:16418779	PMID:18957693	PMID:19079182	PMID:19155473	PMID:21841309	PMID:24990881	PMID:25631124	PMID:26949937
PMID:27044754	PMID:27477018	PMID:27589997	PMID:27662313	PMID:27995897	PMID:28483841	PMID:28547529	PMID:28592261	PMID:28802038	PMID:28849042	PMID:28855300	PMID:28855301
PMID:29073081	PMID:29518356	PMID:29859094	PMID:30149915	PMID:30232263	PMID:30548312	PMID:32139718	PMID:32757264	PMID:33222683	PMID:36829205

Genomics

Comparative Map Data

Trem2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	12,647,605 - 12,654,190 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	12,647,259 - 12,654,170 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	21,160,724 - 21,167,248 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	9	26,226,948 - 26,233,472 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	9	24,616,230 - 24,622,771 (-)	NCBI	Rnor_WKY
Rnor_6.0	9	14,611,541 - 14,618,076 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	14,611,561 - 14,618,013 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	13,532,905 - 13,539,382 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	8,059,023 - 8,065,585 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	8,059,020 - 8,065,484 (-)	NCBI
Celera	9	10,419,918 - 10,426,480 (-)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

TREM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	41,158,508 - 41,163,116 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	6	41,158,506 - 41,163,186 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	41,126,246 - 41,130,854 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	41,234,230 - 41,238,892 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	41,234,230 - 41,238,892	NCBI
Celera	6	42,678,948 - 42,683,624 (-)	NCBI		Celera
Cytogenetic Map	6	p21.1	NCBI
HuRef	6	40,844,044 - 40,848,724 (-)	NCBI		HuRef
CHM1_1	6	41,129,139 - 41,133,819 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	40,987,077 - 40,991,685 (-)	NCBI		T2T-CHM13v2.0

Trem2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	48,653,429 - 48,659,304 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	48,653,429 - 48,661,175 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	48,346,401 - 48,352,276 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	48,346,401 - 48,354,147 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	48,485,726 - 48,491,598 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	47,811,968 - 47,817,840 (+)	NCBI		MGSCv36	mm8
Celera	17	51,775,275 - 51,781,147 (+)	NCBI		Celera
Cytogenetic Map	17	C	NCBI

Trem2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	7,780,679 - 7,785,697 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	7,780,886 - 7,785,597 (-)	NCBI	ChiLan1.0	ChiLan1.0

TREM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	6	51,513,212 - 51,517,926 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	40,735,483 - 40,740,208 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	42,043,887 - 42,048,578 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	42,043,900 - 42,048,578 (-)	Ensembl	panpan1.1		panPan2

Trem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	45,295,126 - 45,300,504 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	18,659,815 - 18,663,940 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936476	18,659,725 - 18,665,406 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TREM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	36,465,324 - 36,471,516 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	36,465,921 - 36,471,509 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	41,763,412 - 41,767,191 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TREM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	30,965,091 - 30,999,073 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	30,994,357 - 30,999,087 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	41,158,611 - 41,163,469 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trem2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	17,643,363 - 17,648,231 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	17,643,397 - 17,649,255 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Trem2
86 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	40
Count of miRNA genes:	38
Interacting mature miRNAs:	38
Transcripts:	ENSRNOT00000018351
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10054141	Gmadr4	Adrenal mass QTL 4	2.45	0.0074	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	9	1	14209783	Rat
70226	Eae4	Experimental allergic encephalomyelitis QTL 4			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	9	1	25661317	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	1	37999212	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	1	37999212	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	1	37999212	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	40594091	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	1	43718459	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	1	43718459	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	1254084	46254084	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	1254084	46254084	Rat
1578675	Bss17	Bone structure and strength QTL 17	3.8		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	9	3368652	13533896	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	5109826	42921101	Rat
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5109826	50109826	Rat
11353947	Bp392	Blood pressure QTL 392			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	7283252	52283252	Rat
61450	Ciaa3	CIA Autoantibody QTL 3	6.5		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	9	7954720	22071169	Rat
9589133	Insul26	Insulin level QTL 26	17.96	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	9	8952560	53952560	Rat
7411609	Foco16	Food consumption QTL 16	25.6	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	8952560	53952560	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									8		5	8
Low	2	33	13	3	8	3	6	8	60	33	28	3	6
Below cutoff	1	4	38	32	11	32	2	3	4	2	6		2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006244424	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006244425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229837	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	MN207145	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	MN207146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000018351 ⟹ ENSRNOP00000018351

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	12,647,608 - 12,654,170 (-)	Ensembl
Rnor_6.0 Ensembl	9	14,611,561 - 14,618,013 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093814 ⟹ ENSRNOP00000077250

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	12,647,259 - 12,654,170 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000112464 ⟹ ENSRNOP00000087941

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	12,647,887 - 12,651,892 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000114012 ⟹ ENSRNOP00000086823

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	12,647,606 - 12,654,170 (-)	Ensembl

RefSeq Acc Id:

NM_001106884 ⟹ NP_001100354

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	12,647,608 - 12,654,170 (-)	NCBI
Rnor_6.0	9	14,611,561 - 14,618,013 (-)	NCBI
Rnor_5.0	9	13,532,905 - 13,539,382 (-)	NCBI
RGSC_v3.4	9	8,059,023 - 8,065,585 (-)	RGD
Celera	9	10,419,918 - 10,426,480 (-)	RGD

Sequence:

show sequence

ATCACAGCGCCCACCCTAGTCCTGGCTGTTGGTTGCTCAATCCAGGAGCACAGTTCCTGTGGGC
TGAGCCTGACTGGCTTGGTCATCTCTTTTCTGCACTTCAAGGGAAAAACAAGATCTGACACAAG
GGACCCCTGCGTCTGTCCCCTCCGGCTGGCTGAGGAAGGGTGCCATGGAACCTCTCCACGTGTT
TGTCCTGTTGCTGGTCACAGAGCTGTCCCAAGCCCTCAACACCACAGTGCTGCAGGGTGTGGCT
GGTCAGTCCCTGAGGGTGTCATGTACTTATGACGCCTTGAGGCACTGGGGACGACGAAAGGCCT
GGTGTCGCCAGCTGGCTGAGGAGGGGCCATGCCAGCGCGTGGTGAGCACACACGGTGTGTGGCT
GCTGGCCTTCCTGAGGAAGCAGAATGGGAGCACGGTCATCACAGATGACACCCTTGCTGGAACT
GTCACCATCACTCTGAGGAACCTCCAAGCTGGTGATGCAGGCCTCTACCAGTGTCAGAGCCTCC
GAGGCCGAGAGGCTGAGGTCCTCCAGAAGGTCGTGGTGGAGGTGCTGGAGGACCCTCTAGATGA
CCAAGATGCTGGAGACCTCTGGGTCCCCGAGGAGTCAGAGAGTTTCGAAGGGGCCCAAGTGGAG
CACAGCACCTCCAGTCAGGTTTCATCCTGTGGGTCACCTCTAACCTACCATCTTCCTCCCAAGG
AGCCAATCAGGAAAGACCTTCTCCCCACCCACTTCCATTCTTCTCCTCCTGGCCTGTGTCCTCC
TGAGCAAGCTTCTTACAGCCAGCATCCTCTGGGCTGTGGCCAGGGGCAGGCAGAAGCTGGAGAC
ACCTGTGGCCAGTGGGCTAGACTGTAGCCAAGATGCTGGGCACCAACTTCAGATCCTCACTGGA
CCCAGAGGTATGTGAGAGAAGTCTGAGTAGGAGGAGAATTACAGCTTAAGTCCAGCCAGGAGCC
AATCCAATTGGCATACTCTCCCCTCCACCACCAAGACTTCTGTTCTGCTACTTTTTCTTCAGAG
GCCACGTCTGCCTAAAGCCCACCTATCCCGGGAGCAGGAATACTGGTGTGCTGCATCTGCGTTG
AGTGGGGAAGACAGCTGGATGGTTGCTGGTAAACGTCTGTACTTTGGACATTAAACACTCTCAC
ACACC

hide sequence

RefSeq Acc Id:

XM_006244424 ⟹ XP_006244486

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	12,647,605 - 12,654,190 (-)	NCBI
Rnor_6.0	9	14,611,541 - 14,618,076 (-)	NCBI
Rnor_5.0	9	13,532,905 - 13,539,382 (-)	NCBI

Sequence:

show sequence

AGACAGCTGACCTTTATGCAGAAGCCTCCTTTCCTTCCTCCCTCGTGCCCTTCTCCTCCTTGAA
TCACAGCGCCCACCCTAGTCCTGGCTGTTGGTTGCTCAATCCAGGAGCACAGTTCCTGTGGGCT
GAGCCTGACTGGCTTGGTCATCTCTTTTCTGCACTTCAAGGGAAAAACAAGATCTGACACAAGG
GACCCCTGCGTCTGTCCCCTCCGGCTGGCTGAGGAAGGGTGCCATGGAACCTCTCCACGTGTTT
GTCCTGTTGCTGGTCACAGAGCTGTCCCAAGCCCTCAACACCACAGTGCTGCAGGGTGTGGCTG
GTCAGTCCCTGAGGGTGTCATGTACTTATGACGCCTTGAGGCACTGGGGACGACGAAAGGCCTG
GTGTCGCCAGCTGGCTGAGGAGGGGCCATGCCAGCGCGTGGTGAGCACACACGGTGTGTGGCTG
CTGGCCTTCCTGAGGAAGCAGAATGGGAGCACGGTCATCACAGATGACACCCTTGCTGGAACTG
TCACCATCACTCTGAGGAACCTCCAAGCTGGTGATGCAGGCCTCTACCAGTGTCAGAGCCTCCG
AGGCCGAGAGGCTGAGGTCCTCCAGAAGGTCGTGGTGGAGGTGCTGGAGGACCCTCTAGATGAC
CAAGATGCTGGAGACCTCTGGGTCCCCGAGGAGTCAGAGAGTTTCGAAGGGGCCCAAGTGGAGC
ACAGCACCTCCAGGAGCCAATCAGGAAAGACCTTCTCCCCACCCACTTCCATTCTTCTCCTCCT
GGCCTGTGTCCTCCTGAGCAAGCTTCTTACAGCCAGCATCCTCTGGGCTGTGGCCAGGGGCAGG
CAGAAGCTGGAGACACCTGTGGCCAGTGGGCTAGACTGTAGCCAAGATGCTGGGCACCAACTTC
AGATCCTCACTGGACCCAGAGAGGCCACGTCTGCCTAAAGCCCACCTATCCCGGGAGCAGGAAT
ACTGGTGTGCTGCATCTGCGTTGAGTGGGGAAGACAGCTGGATGGTTGCTGGTAAACGTCTGTA
CTTTGGACATTAAACACTCTCACACACCAACCCAGGACTGTCTGCTCT

hide sequence

RefSeq Acc Id:

XM_006244425 ⟹ XP_006244487

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	12,647,606 - 12,654,189 (-)	NCBI
Rnor_6.0	9	14,611,559 - 14,618,073 (-)	NCBI
Rnor_5.0	9	13,532,905 - 13,539,382 (-)	NCBI

Sequence:

show sequence

CAGCTGACCTTTATGCAGAAGCCTCCTTTCCTTCCTCCCTCGTGCCCTTCTCCTCCTTGAATCA
CAGCGCCCACCCTAGTCCTGGCTGTTGGTTGCTCAATCCAGGAGCACAGTTCCTGTGGGCTGAG
CCTGACTGGCTTGGTCATCTCTTTTCTGCACTTCAAGGGAAAAACAAGATCTGACACAAGGGAC
CCCTGCGTCTGTCCCCTCCGGCTGGCTGAGGAAGGGTGCCATGGAACCTCTCCACGTGTTTGTC
CTGTTGCTGGTCACAGAGCTGTCCCAAGCCCTCAACACCACAGTGCTGCAGGGTGTGGCTGGTC
AGTCCCTGAGGGTGTCATGTACTTATGACGCCTTGAGGCACTGGGGACGACGAAAGGCCTGGTG
TCGCCAGCTGGCTGAGGAGGGGCCATGCCAGCGCGTGGTGAGCACACACGGTGTGTGGCTGCTG
GCCTTCCTGAGGAAGCAGAATGGGAGCACGGTCATCACAGATGACACCCTTGCTGGAACTGTCA
CCATCACTCTGAGGAACCTCCAAGCTGGTGATGCAGGCCTCTACCAGTGTCAGAGCCTCCGAGG
CCGAGAGGCTGAGGTCCTCCAGAAGGTCGTGGTGGAGGTGCTGGAGGACCCTCTAGATGACCAA
GATGCTGGAGACCTCTGGGTCCCCGAGGAGTCAGAGAGTTTCGAAGGGGCCCAAGTGGAGCACA
GCACCTCCAGGAGCCAATCAGGAAAGACCTTCTCCCCACCCACTTCCATTCTTCTCCTCCTGGC
CTGTGTCCTCCTGAGCAAGCTTCTTACAGCCAGCATCCTCTGGGCTGTGGCCAGGGGCAGGCAG
AAGCTGGAGACACCTGTGGCCAGTGGGCTAGACTGTAGCCAAGATGCTGGGCACCAACTTCAGA
TCCTCACTGAGGCCACGTCTGCCTAAAGCCCACCTATCCCGGGAGCAGGAATACTGGTGTGCTG
CATCTGCGTTGAGTGGGGAAGACAGCTGGATGGTTGCTGGTAAACGTCTGTACTTTGGACATTA
AACACTCTCACACACCAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100354	(Get FASTA)	NCBI Sequence Viewer
	XP_006244486	(Get FASTA)	NCBI Sequence Viewer
	XP_006244487	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM18925	(Get FASTA)	NCBI Sequence Viewer
	EDM18926	(Get FASTA)	NCBI Sequence Viewer
	EDM18927	(Get FASTA)	NCBI Sequence Viewer
	EDM18928	(Get FASTA)	NCBI Sequence Viewer
	QIN52961	(Get FASTA)	NCBI Sequence Viewer
	QIN52962	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001100354 ⟸ NM_001106884
- Peptide Label:	precursor
- UniProtKB:	D3ZZ89 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEPLHVFVLLLVTELSQALNTTVLQGVAGQSLRVSCTYDALRHWGRRKAWCRQLAEEGPCQRVV STHGVWLLAFLRKQNGSTVITDDTLAGTVTITLRNLQAGDAGLYQCQSLRGREAEVLQKVVVEV LEDPLDDQDAGDLWVPEESESFEGAQVEHSTSSQVSSCGSPLTYHLPPKEPIRKDLLPTHFHSS PPGLCPPEQASYSQHPLGCGQGQAEAGDTCGQWARL hide sequence

RefSeq Acc Id:	XP_006244486 ⟸ XM_006244424
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A303 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEPLHVFVLLLVTELSQALNTTVLQGVAGQSLRVSCTYDALRHWGRRKAWCRQLAEEGPCQRVV STHGVWLLAFLRKQNGSTVITDDTLAGTVTITLRNLQAGDAGLYQCQSLRGREAEVLQKVVVEV LEDPLDDQDAGDLWVPEESESFEGAQVEHSTSRSQSGKTFSPPTSILLLLACVLLSKLLTASIL WAVARGRQKLETPVASGLDCSQDAGHQLQILTGPREATSA hide sequence

RefSeq Acc Id:	XP_006244487 ⟸ XM_006244425
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5Y9E9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEPLHVFVLLLVTELSQALNTTVLQGVAGQSLRVSCTYDALRHWGRRKAWCRQLAEEGPCQRVV STHGVWLLAFLRKQNGSTVITDDTLAGTVTITLRNLQAGDAGLYQCQSLRGREAEVLQKVVVEV LEDPLDDQDAGDLWVPEESESFEGAQVEHSTSRSQSGKTFSPPTSILLLLACVLLSKLLTASIL WAVARGRQKLETPVASGLDCSQDAGHQLQILTEATSA hide sequence

RefSeq Acc Id:

ENSRNOP00000018351 ⟸ ENSRNOT00000018351

RefSeq Acc Id:

ENSRNOP00000086823 ⟸ ENSRNOT00000114012

RefSeq Acc Id:

ENSRNOP00000077250 ⟸ ENSRNOT00000093814

RefSeq Acc Id:

ENSRNOP00000087941 ⟸ ENSRNOT00000112464

Protein Domains

Ig-like Immunoglobulin subtype

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZZ89-F1-model_v2	AlphaFold	D3ZZ89	1-228	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309841	AgrOrtholog
BioCyc Gene	G2FUF-28307	BioCyc
Ensembl Genes	ENSRNOG00000013578	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000018351	ENTREZGENE
	ENSRNOP00000018351.6	UniProtKB/TrEMBL
	ENSRNOP00000077250	ENTREZGENE
	ENSRNOP00000077250.1	UniProtKB/TrEMBL
	ENSRNOP00000086823	ENTREZGENE
	ENSRNOP00000086823.1	UniProtKB/TrEMBL
	ENSRNOP00000087941.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000018351	ENTREZGENE
	ENSRNOT00000018351.6	UniProtKB/TrEMBL
	ENSRNOT00000093814	ENTREZGENE
	ENSRNOT00000093814.1	UniProtKB/TrEMBL
	ENSRNOT00000112464.1	UniProtKB/TrEMBL
	ENSRNOT00000114012	ENTREZGENE
	ENSRNOT00000114012.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	Ig-like_dom	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_V-set	UniProtKB/TrEMBL
KEGG Report	rno:301227	UniProtKB/TrEMBL
NCBI Gene	301227	ENTREZGENE
PANTHER	IG-LIKE DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	TREM-LIKE TRANSCRIPT PROTEIN	UniProtKB/TrEMBL
Pfam	V-set	UniProtKB/TrEMBL
PhenoGen	Trem2	PhenoGen
PROSITE	IG_LIKE	UniProtKB/TrEMBL
SMART	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	A0A6G8MV71_RAT	UniProtKB/TrEMBL
	A0A6G8MVL9_RAT	UniProtKB/TrEMBL
	A0A8I5Y9E9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A303	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A9R5_RAT	UniProtKB/TrEMBL
	D3ZZ89	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Trem2	triggering receptor expressed on myeloid cells 2	Trem2_predicted	triggering receptor expressed on myeloid cells 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Trem2_predicted	triggering receptor expressed on myeloid cells 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI

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