Ppp1r15b (protein phosphatase 1, regulatory subunit 15B) - Rat Genome Database

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Gene: Ppp1r15b (protein phosphatase 1, regulatory subunit 15B) Rattus norvegicus
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Symbol: Ppp1r15b
Name: protein phosphatase 1, regulatory subunit 15B
RGD ID: 1307944
Description: Predicted to enable protein phosphatase regulator activity. Predicted to be involved in peptidyl-serine dephosphorylation; regulation of protein modification process; and response to endoplasmic reticulum stress. Predicted to act upstream of or within ER overload response; regulation of catalytic activity; and response to hydrogen peroxide. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Orthologous to human PPP1R15B (protein phosphatase 1 regulatory subunit 15B); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC304799; protein phosphatase 1 regulatory subunit 15B; protein phosphatase 1, regulatory (inhibitor) subunit 15b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21344,577,840 - 44,585,737 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1344,577,932 - 44,585,737 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1347,184,765 - 47,192,575 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01348,472,871 - 48,480,681 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01345,733,607 - 45,741,415 (+)NCBIRnor_WKY
Rnor_6.01349,933,155 - 49,940,961 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1349,933,155 - 49,940,961 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,000,733 - 55,009,310 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,039,831 - 46,047,636 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11346,054,316 - 46,059,219 (+)NCBI
Celera1344,911,789 - 44,919,594 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14638860   PMID:16835242   PMID:26307080  


Genomics

Comparative Map Data
Ppp1r15b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21344,577,840 - 44,585,737 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1344,577,932 - 44,585,737 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1347,184,765 - 47,192,575 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01348,472,871 - 48,480,681 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01345,733,607 - 45,741,415 (+)NCBIRnor_WKY
Rnor_6.01349,933,155 - 49,940,961 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1349,933,155 - 49,940,961 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,000,733 - 55,009,310 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,039,831 - 46,047,636 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11346,054,316 - 46,059,219 (+)NCBI
Celera1344,911,789 - 44,919,594 (+)NCBICelera
Cytogenetic Map13q13NCBI
PPP1R15B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381204,395,826 - 204,411,817 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1204,396,492 - 204,411,887 (-)EnsemblGRCh38hg38GRCh38
GRCh371204,372,509 - 204,380,945 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361202,639,143 - 202,647,542 (-)NCBINCBI36Build 36hg18NCBI36
Build 341201,104,177 - 201,112,576NCBI
Celera1177,507,930 - 177,516,383 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1175,537,638 - 175,546,091 (-)NCBIHuRef
CHM1_11205,796,366 - 205,804,818 (-)NCBICHM1_1
T2T-CHM13v2.01203,667,982 - 203,676,419 (-)NCBIT2T-CHM13v2.0
Ppp1r15b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,058,904 - 133,067,538 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1133,058,881 - 133,067,521 (+)EnsemblGRCm39 Ensembl
GRCm381133,131,166 - 133,139,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,131,143 - 133,139,783 (+)EnsemblGRCm38mm10GRCm38
MGSCv371135,027,743 - 135,036,377 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361134,959,009 - 134,964,774 (+)NCBIMGSCv36mm8
Celera1135,742,823 - 135,751,462 (+)NCBICelera
Cytogenetic Map1E4NCBI
Ppp1r15b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540640,232,607 - 40,238,901 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540640,232,516 - 40,238,711 (-)NCBIChiLan1.0ChiLan1.0
PPP1R15B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11184,293,640 - 184,302,316 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,293,640 - 184,302,316 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01180,002,895 - 180,014,956 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PPP1R15B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.138957,320 - 965,683 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl38959,721 - 965,933 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha381,052,428 - 1,060,354 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.038952,823 - 960,760 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl38948,852 - 961,475 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.138949,091 - 957,044 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0381,340,630 - 1,348,734 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0381,541,016 - 1,548,950 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r15b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934471,154,271 - 71,163,124 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936567388,774 - 397,855 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936567388,623 - 397,723 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R15B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl965,056,398 - 65,066,775 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1965,056,495 - 65,069,083 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2971,392,198 - 71,403,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R15B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12524,935,435 - 24,945,220 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605525,697,090 - 25,705,519 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r15b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248076,623,245 - 6,633,334 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248076,622,816 - 6,631,027 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r15b
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:856
Count of miRNA genes:318
Interacting mature miRNAs:431
Transcripts:ENSRNOT00000037039
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134343790447841255Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat

Markers in Region
RH133563  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21344,585,422 - 44,585,623 (+)MAPPERmRatBN7.2
Rnor_6.01349,940,647 - 49,940,847NCBIRnor6.0
Rnor_5.01355,008,996 - 55,009,196UniSTSRnor5.0
RGSC_v3.41346,047,322 - 46,047,522UniSTSRGSC3.4
Celera1344,919,280 - 44,919,480UniSTS
Cytogenetic Map13q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 57 41 19 41 8 8 74 35 37 11 8
Low 11 3 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000037039   ⟹   ENSRNOP00000034252
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1344,577,932 - 44,585,737 (+)Ensembl
Rnor_6.0 Ensembl1349,933,155 - 49,940,961 (+)Ensembl
RefSeq Acc Id: NM_001107175   ⟹   NP_001100645
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21344,577,932 - 44,585,737 (+)NCBI
Rnor_6.01349,933,155 - 49,940,961 (+)NCBI
Rnor_5.01355,000,733 - 55,009,310 (+)NCBI
RGSC_v3.41346,039,831 - 46,047,636 (+)RGD
Celera1344,911,789 - 44,919,594 (+)RGD
Sequence:
RefSeq Acc Id: XM_039090710   ⟹   XP_038946638
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21344,577,840 - 44,585,733 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001100645 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946638 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68909 (Get FASTA)   NCBI Sequence Viewer  
  EDM09778 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100645   ⟸   NM_001107175
- UniProtKB: D3ZP67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034252   ⟸   ENSRNOT00000037039
RefSeq Acc Id: XP_038946638   ⟸   XM_039090710
- Peptide Label: isoform X1
Protein Domains
CReP_N   PP1c_bdg

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZP67-F1-model_v2 AlphaFold D3ZP67 1-707 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698820
Promoter ID:EPDNEW_R9344
Type:initiation region
Name:Ppp1r15b_1
Description:protein phosphatase 1, regulatory subunit 15B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01349,933,217 - 49,933,277EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307944 AgrOrtholog
BioCyc Gene G2FUF-18293 BioCyc
Ensembl Genes ENSRNOG00000028493 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000034252 ENTREZGENE
  ENSRNOP00000034252.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037039 ENTREZGENE
  ENSRNOT00000037039.7 UniProtKB/TrEMBL
InterPro Prot_Pase1_reg-su15A/B_C UniProtKB/TrEMBL
  Prot_Pase1_reg-su15B_N UniProtKB/TrEMBL
KEGG Report rno:304799 UniProtKB/TrEMBL
NCBI Gene 304799 ENTREZGENE
Pfam CReP_N UniProtKB/TrEMBL
  PP1c_bdg UniProtKB/TrEMBL
PhenoGen Ppp1r15b PhenoGen
UniProt D3ZP67 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-18 Ppp1r15b  protein phosphatase 1, regulatory subunit 15B  Ppp1r15b  protein phosphatase 1, regulatory (inhibitor) subunit 15b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ppp1r15b  protein phosphatase 1, regulatory (inhibitor) subunit 15b   Ppp1r15b_predicted  protein phosphatase 1, regulatory (inhibitor) subunit 15b (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ppp1r15b_predicted  protein phosphatase 1, regulatory (inhibitor) subunit 15b (predicted)      Symbol and Name status set to approved 70820 APPROVED