Spry2 (sprouty RTK signaling antagonist 2)

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Gene: Spry2 (sprouty RTK signaling antagonist 2) Rattus norvegicus

Analyze

Symbol:

Spry2

Name:

sprouty RTK signaling antagonist 2

RGD ID:

1311472

Description:

Predicted to have protein kinase binding activity and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including lung development; regulation of protein phosphorylation; and regulation of signal transduction. Predicted to localize to several cellular components, including cytoskeleton; cytosol; and nucleus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2); PARTICIPATES IN fibroblast growth factor signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; dibutyl phthalate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

LOC306141; sprouty 2; sprouty homolog 2; sprouty homolog 2 (Drosophila)

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SPRY2 (sprouty RTK signaling antagonist 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Spry2 (sprouty RTK signaling antagonist 2)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Spry2 (sprouty RTK signaling antagonist 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SPRY2 (sprouty RTK signaling antagonist 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SPRY2 (sprouty RTK signaling antagonist 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Spry2 (sprouty RTK signaling antagonist 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SPRY2 (sprouty RTK signaling antagonist 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	SPRY2 (sprouty RTK signaling antagonist 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Spry2 (sprouty RTK signaling antagonist 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SPRY2 (sprouty RTK signaling antagonist 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Spry2 (sprouty RTK signaling antagonist 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	spry2 (sprouty RTK signaling antagonist 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	sty	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	82,692,312 - 82,697,408 (-)	NCBI
Rnor_6.0 Ensembl	15	90,172,975 - 90,175,802 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	15	90,172,769 - 90,177,823 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	15	93,662,768 - 93,667,781 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	90,009,109 - 90,011,940 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	15	90,024,884 - 90,027,720 (-)	NCBI
Celera	15	81,798,483 - 81,801,309 (-)	NCBI		Celera
Cytogenetic Map	15	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

achalasia (ISS)

Chromosome 13q Deletion Syndrome (ISO)

chromosome 13q14 deletion syndrome (ISO)

cleft lip (ISO)

cleft palate (ISO)

COVID-19 (ISO)

Craniofacial Abnormalities (ISO)

IgA glomerulonephritis (ISO)

intestinal pseudo-obstruction (ISS)

lung disease (ISO)

Lung Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxynon-2-enal (ISO)

8-Br-cAMP (ISO)

acetaldehyde (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

bisphenol A (EXP,ISO)

calcitriol (ISO)

carbamazepine (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

cyproconazole (ISO)

D-glucose (ISO)

dibutyl phthalate (EXP,ISO)

dioxygen (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

fluoranthene (ISO)

fluoxetine (ISO)

flusilazole (ISO)

formaldehyde (ISO)

furan (EXP)

glucose (ISO)

hydrogen peroxide (ISO)

isobutanol (ISO)

lead diacetate (ISO)

leflunomide (ISO)

menadione (ISO)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

methylmercury chloride (ISO)

N-methyl-N-nitrosourea (EXP)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

nickel dichloride (ISO)

nitrofen (EXP)

paracetamol (ISO)

PD 0325901 (ISO)

phenobarbital (ISO)

phorone (EXP)

pirinixic acid (ISO)

potassium chromate (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (EXP)

Soman (EXP)

succimer (ISO)

sunitinib (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

taurine (ISO)

Tesaglitazar (EXP)

thapsigargin (ISO)

torcetrapib (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

valsartan (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ development (IBA)

branching morphogenesis of an epithelial tube (ISO)

bud elongation involved in lung branching (ISO)

cell fate commitment (ISO)

cellular response to leukemia inhibitory factor (ISO)

cellular response to vascular endothelial growth factor stimulus (ISO)

establishment of mitotic spindle orientation (ISO)

inner ear morphogenesis (ISO)

lung development (ISO)

lung growth (ISO)

lung morphogenesis (ISO)

negative regulation of angiogenesis (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of cell population proliferation (ISO)

negative regulation of cell projection organization (ISO)

negative regulation of epithelial to mesenchymal transition (ISO)

negative regulation of ERK1 and ERK2 cascade (ISO)

negative regulation of fibroblast growth factor receptor signaling pathway (IBA,ISO)

negative regulation of GTPase activity (ISO)

negative regulation of lens fiber cell differentiation (ISO)

negative regulation of MAP kinase activity (IBA,ISO)

negative regulation of neurotrophin TRK receptor signaling pathway (ISO)

negative regulation of peptidyl-threonine phosphorylation (ISO)

negative regulation of protein ubiquitination (IEA,ISO)

negative regulation of Ras protein signal transduction (IBA,ISO)

negative regulation of transforming growth factor beta receptor signaling pathway (ISO)

negative regulation of vascular endothelial growth factor signaling pathway (ISO)

positive regulation of cell migration (ISO)

positive regulation of ERK1 and ERK2 cascade (ISO)

positive regulation of gene expression (ISO)

positive regulation of peptidyl-serine phosphorylation (ISO)

positive regulation of protein kinase B signaling (ISO)

positive regulation of protein serine/threonine kinase activity (IEA)

respiratory system development (ISO)

sensory perception of sound (ISO)

Cellular Component

actin cytoskeleton (IEA,ISO)

cytoskeleton (ISO)

cytosol (IBA,ISO)

membrane (ISO)

microtubule cytoskeleton (ISO)

microtubule end (IEA,ISO)

nucleus (ISO)

ruffle membrane (IEA)

Molecular Function

protein binding (ISO)

protein kinase binding (ISO)

protein serine/threonine kinase activator activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

fibroblast growth factor signaling pathway (ISO)

Jak-Stat signaling pathway (IEA)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA data from the GO Consortium
3.	MGD data from the GO Consortium
4.	Pipeline to import KEGG annotations from KEGG into RGD
5.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6.	RGD automated data pipeline
7.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10074434	PMID:11287183	PMID:11585837	PMID:12477932	PMID:15809037	PMID:16339969	PMID:16893902	PMID:17141539	PMID:17255109	PMID:18070883	PMID:18508928	PMID:19683577
PMID:20029031	PMID:20439489	PMID:20489163	PMID:20736167	PMID:21536891	PMID:21764747	PMID:22236546	PMID:23982388	PMID:24177325	PMID:24210189	PMID:24469046	PMID:25822989
PMID:29409968

Genomics

Comparative Map Data

Spry2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	82,692,312 - 82,697,408 (-)	NCBI
Rnor_6.0 Ensembl	15	90,172,975 - 90,175,802 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	15	90,172,769 - 90,177,823 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	15	93,662,768 - 93,667,781 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	90,009,109 - 90,011,940 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	15	90,024,884 - 90,027,720 (-)	NCBI
Celera	15	81,798,483 - 81,801,309 (-)	NCBI		Celera
Cytogenetic Map	15	q22	NCBI

SPRY2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	13	80,335,976 - 80,341,126 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	13	80,335,976 - 80,341,126 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	13	80,910,111 - 80,915,261 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	13	80,910,111 - 80,915,086 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	79,808,112 - 79,813,087 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	13	79,808,114 - 79,813,087	NCBI
Celera	13	61,811,860 - 61,816,835 (-)	NCBI
Cytogenetic Map	13	q31.1	NCBI
HuRef	13	61,613,784 - 61,618,759 (-)	NCBI		HuRef
CHM1_1	13	80,877,733 - 80,882,872 (-)	NCBI		CHM1_1

Spry2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	106,129,381 - 106,134,899 (-)	NCBI	GRCm39		mm39
GRCm38	14	105,891,947 - 105,896,819 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	105,891,947 - 105,896,819 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	106,291,164 - 106,296,036 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	14	104,778,114 - 104,782,418 (-)	NCBI			mm8
Celera	14	104,512,649 - 104,517,512 (-)	NCBI		Celera
Cytogenetic Map	14	E2.3	NCBI
cM Map	14	56.16	NCBI

Spry2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	27,349,519 - 27,353,706 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955404	27,349,286 - 27,353,706 (+)	NCBI	ChiLan1.0	ChiLan1.0

SPRY2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	13	80,595,679 - 80,600,670 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	80,596,346 - 80,597,408 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	13	61,569,658 - 61,574,817 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

SPRY2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	22	33,366,931 - 33,367,878 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	22	33,366,139 - 33,371,102 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Spry2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936511	1,452,421 - 1,458,031 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPRY2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	52,153,704 - 52,160,497 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	52,153,695 - 52,158,766 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	56,943,755 - 56,948,261 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPRY2
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	59,357,611 - 59,362,705 (-)	NCBI
ChlSab1.1 Ensembl	3	59,358,394 - 59,359,341 (-)	Ensembl

Spry2
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624751	20,091,612 - 20,096,581 (+)	NCBI

Position Markers

RH143991

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	15	90,173,234 - 90,173,382	NCBI	Rnor6.0
Rnor_5.0	15	93,663,212 - 93,663,360	UniSTS	Rnor5.0
RGSC_v3.4	15	90,009,372 - 90,009,520	UniSTS	RGSC3.4
Celera	15	81,798,746 - 81,798,894	UniSTS
RH 3.4 Map	15	551.19	UniSTS
Cytogenetic Map	15	q22	UniSTS

RH44769

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	15	90,177,392 - 90,177,655	NCBI	Rnor6.0
Rnor_5.0	15	93,667,370 - 93,667,633	UniSTS	Rnor5.0
RGSC_v3.4	15	90,013,530 - 90,013,793	UniSTS	RGSC3.4
Celera	15	81,802,899 - 81,803,162	UniSTS
Cytogenetic Map	15	q22	UniSTS

BQ201059

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	15	90,173,785 - 90,173,980	NCBI	Rnor6.0
Rnor_5.0	15	93,663,763 - 93,663,958	UniSTS	Rnor5.0
RGSC_v3.4	15	90,009,923 - 90,010,118	UniSTS	RGSC3.4
Celera	15	81,799,297 - 81,799,487	UniSTS
RH 3.4 Map	15	551.0	UniSTS
Cytogenetic Map	15	q22	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	26381041	106550657	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	26381041	106550657	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	26381041	106550657	Rat
1300144	Rf23	Renal function QTL 23	3.61		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	15	43097470	106550657	Rat
1576315	Schws6	Schwannoma susceptibility QTL 6		0.0069	nervous system integrity trait (VT:0010566)	post-insult time of death (CMO:0002005)	15	61447766	106447766	Rat
61477	Aia4	Adjuvant induced arthritis QTL 4	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	15	62596410	99372139	Rat
631516	Gluco31	Glucose level QTL 31	7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	62596410	103164962	Rat
631655	Bp126	Blood pressure QTL 126	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	65520564	110520564	Rat
731177	Uae26	Urinary albumin excretion QTL 26	2.4	0.025	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	15	75527634	111246239	Rat
2300326	Plaw1	Placental weight QTL 1	15	0.005	placenta mass (VT:0004257)	placenta wet weight (CMO:0002088)	15	75761024	109400896	Rat
1331724	Bp223	Blood pressure QTL 223	3.53715		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	81255292	103165069	Rat
1641889	Colcr6	Colorectal carcinoma resistance QTL 6	2.9	0.0126	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	15	81255292	109133904	Rat
70182	BpQTLcluster12	Blood pressure QTL cluster 12	3.53		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	15	81255430	103164962	Rat
1581555	Eae19	Experimental allergic encephalomyelitis QTL 19	4.7		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	15	83947714	98027710	Rat
70155	Gcs1	Gastric cancer susceptibility QTL1	3.8		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	15	83947714	111246239	Rat
1549844	Bss7	Bone structure and strength QTL 7	6.4		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	15	84050550	111246239	Rat
2317055	Aia10	Adjuvant induced arthritis QTL 10	3.41		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	15	84050550	111246239	Rat
1300118	Bp190	Blood pressure QTL 190	2.94		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	15	89640684	106550657	Rat
1300120	Kidm7	Kidney mass QTL 7	3.55		kidney mass (VT:0002707)	left kidney wet weight to body weight ratio (CMO:0001954)	15	89640684	106550657	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	354
Count of miRNA genes:	211
Interacting mature miRNAs:	248
Transcripts:	ENSRNOT00000013342
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	36	7	6	4	6	1	4	74	30	33	11	1
Low		7	50	35	15	35	7	7		5	8		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006252438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC089116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000013342 ⟹ ENSRNOP00000013342

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	15	90,172,975 - 90,175,802 (-)	Ensembl

RefSeq Acc Id:

NM_001012046 ⟹ NP_001012046

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	82,692,493 - 82,695,324 (-)	NCBI
Rnor_6.0	15	90,172,971 - 90,175,802 (-)	NCBI
Rnor_5.0	15	93,662,768 - 93,667,781 (-)	NCBI
RGSC_v3.4	15	90,009,109 - 90,011,940 (-)	RGD
Celera	15	81,798,483 - 81,801,309 (-)	RGD

Sequence:

show sequence

GGGAGGGGCCGGTCTGGCCCTTGGACCGCATCAGTCGGCTTGGAGAAAAGTCCCCCGGGGTTCT
GGCTGAGTCCCACCTGCTGGGGACTGTGTGGGGGCGCTGATAGAGCCGATAAACGGGTTGGGTT
GAAAGCGAAGAACAGCCTTGTGTACCTTGCTGTTGGAGGAGTTCAGATGTGTTCTAAGCCTGCT
GGAGTGAACACACCGCCAAGATCTGATGGAGGCCAGAGCTCAGAGCGGCAGCGGGTCGCAGCCT
TTGCTGCAGTCACCCCATGACAGTGGCAGGCAGCGTGGGGAGCCGGACCCCAGAGATGCCCTTA
CCCAGCAGGTACATGTCTTGTCTCTGGATCAGATCAGAGCCATCCGAAACACCAATGAGTACAC
AGAGGGGCCTACTGTGGTCCCAAGACCTGGGCTCAAGCCTGCTCCTCGCCCCTCCACCCAGCAC
AAACATGAAAGACTCCACGGTCTGCCCGAGCACCGCCAGCCTCCCAGGCTCCAGCCCACGCAGG
TCCATTCTTCCCGGGCCGCTCTGTCCAGGTCCGTCAGCACCGTCAGCTCAGGGTCTCGGAGCAG
TACAAGGACAAGTACCAGCAGCAGCTCTTCGGAACAGAGACTGTTAGGATCATCCTTCTCCCCT
GGGCCTGCTGTTGATGGGATAATCCGAGTGCAGCCTAAATCTGAGCTCAAATCCGGTGAGCTTA
AGCCACTGAGCAGAGACGATTTGGGTCTGCATGCATACAGGTGTGAGGACTGTGGCAAGTGCAA
GTGTAAGGAGTGCACCTACCCGAGGCCCCTGCCATCGGACTGGATCTGTGACAAGCAGTGCCTT
TGCTCAGCCCAGAACGTCATTGACTATGGGACTTGTGTGTGCTGTGTGAAAGGTCTCTTCTATC
ACTGCTCCAATGACGACGAGGACAATTGTGCTGACAACCCGTGTTCTTGCAGCCAGTCTCACTG
TTGTACGCGATGGTCAGCGATGGGTGTCATGTCCCTCTTTCTGCCTTGTTTATGGTGTTACCTT
CCAGCCAAGGGTTGCCTTAAATTGTGCCAGGGGTGTTATGACCGAGTGAACAGGCCTGGATGTC
GTTGTAAAAACTCAAATACAGTTTGCTGCAAAGTTCCCACTGTCCCCCCAAGGAACTTTGAAAA
GCCGACATAGCGTTATTAATCAGGAATACTGCAGTAATGAGGATTGTTGCCCCACCCCCACCCC
CTTCTTTTTAACACACATACACAACCTACTAAACAGTTGTAATCGTGGCACTGTTCATAGAGGG
TTAGGGAATTTGTGGTTTGCAGTGAGATGCTTTTCTTTCTTTTTTCCTTTTTTTTTTTCCTCTG
TCCATGTGCCATTTTTTAACTGATACGCTTGCTAGAGAGTTCAGCTAGTCGGAACGCCAGGGAA
AGGCGACAGAAGTTGGTGGCCCCACGTTATTGCATAAGCTAAAGCAGCAAACACCCCCAGGCGA
AGTTTTCTCTTGTTTGTGAATAGCCCTTGCAGAGTTTGTAAATCAGCAGATGGCTCCCCGACCC
CTCCTTGTTTTCTCCAGAGATAATGTGCTATATTTTTGTATATACGATAATATTTGCAACTGTG
AAAAAAAACCAAGTTGTGCTATACTCCCGTGGCACAGTCACAAAATATTATACTAATATGCTGT
ACATTCGGAAGAATGTGACGATCGGTATGTTTTAGATTGTATTTTGCCTTACAGGAAGCCTTTA
TTGTAAGACGCTGACTTCCCTTTGGACTTGATGTATATTGTACAGTTACAGTAAAATTCAACCT
TTATTTTCTAATTTTTTCAACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AGG

hide sequence

RefSeq Acc Id:

XM_006252438 ⟹ XP_006252500

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	82,692,312 - 82,697,408 (-)	NCBI
Rnor_6.0	15	90,172,769 - 90,177,823 (-)	NCBI
Rnor_5.0	15	93,662,768 - 93,667,781 (-)	NCBI

Sequence:

show sequence

GCCCGGCCCGGCCCGCGGCCCCGCGCCTGCCTCCGCTCGGAAGCAGCCCCGGGCCCCCAGGACT
TGGCGAGCTGGCCTTAGGTTCTTTGTAAGGCCGTGCTCGCCTCGCTTTCTCTCATCGACCAGGA
AAAAAAAAAGAGAGACTCGCCAACGTTGGCGCTTCGGCCTCTTGTTCATTGAGAAAAAAAAAGG
GAAAGAAAAAAAAAAGGCAGAGGAAATACTCCGCGTGCGCTTCTGGAACGGAGGTCATCTCTCT
AGCTCGGAATCCGGGAGGGTTCCAACGGTGGAGGATTTGGCTTCCAAATTTTCCCGTGGTTTTA
ATCCTCCCACCGACTGCTTGGAAGTTGGACTGAAGCAGAGTTTGGAGAGAAGGAAAAAGTTTGC
ATCGGGACTGGATTTATTTGCACATCGCTGGAAGAAGAGAATCCAAGGGAGAGGGGTTGGTGCA
AAGCCGCGATCACGGAGTTCAGATGTGTTCTAAGCCTGCTGGAGTGAACACACCGCCAAGATCT
GATGGAGGCCAGAGCTCAGAGCGGCAGCGGGTCGCAGCCTTTGCTGCAGTCACCCCATGACAGT
GGCAGGCAGCGTGGGGAGCCGGACCCCAGAGATGCCCTTACCCAGCAGGTACATGTCTTGTCTC
TGGATCAGATCAGAGCCATCCGAAACACCAATGAGTACACAGAGGGGCCTACTGTGGTCCCAAG
ACCTGGGCTCAAGCCTGCTCCTCGCCCCTCCACCCAGCACAAACATGAAAGACTCCACGGTCTG
CCCGAGCACCGCCAGCCTCCCAGGCTCCAGCCCACGCAGGTCCATTCTTCCCGGGCCGCTCTGT
CCAGGTCCGTCAGCACCGTCAGCTCAGGGTCTCGGAGCAGTACAAGGACAAGTACCAGCAGCAG
CTCTTCGGAACAGAGACTGTTAGGATCATCCTTCTCCCCTGGGCCTGCTGTTGATGGGATAATC
CGAGTGCAGCCTAAATCTGAGCTCAAATCCGGTGAGCTTAAGCCACTGAGCAGAGACGATTTGG
GTCTGCATGCATACAGGTGTGAGGACTGTGGCAAGTGCAAGTGTAAGGAGTGCACCTACCCGAG
GCCCCTGCCATCGGACTGGATCTGTGACAAGCAGTGCCTTTGCTCAGCCCAGAACGTCATTGAC
TATGGGACTTGTGTGTGCTGTGTGAAAGGTCTCTTCTATCACTGCTCCAATGACGACGAGGACA
ATTGTGCTGACAACCCGTGTTCTTGCAGCCAGTCTCACTGTTGTACGCGATGGTCAGCGATGGG
TGTCATGTCCCTCTTTCTGCCTTGTTTATGGTGTTACCTTCCAGCCAAGGGTTGCCTTAAATTG
TGCCAGGGGTGTTATGACCGAGTGAACAGGCCTGGATGTCGTTGTAAAAACTCAAATACAGTTT
GCTGCAAAGTTCCCACTGTCCCCCCAAGGAACTTTGAAAAGCCGACATAGCGTTATTAATCAGG
AATACTGCAGTAATGAGGATTGTTGCCCCACCCCCACCCCCTTCTTTTTAACACACATACACAA
CCTACTAAACAGTTGTAATCGTGGCACTGTTCATAGAGGGTTAGGGAATTTGTGGTTTGCAGTG
AGATGCTTTTCTTTCTTTTTTCCTTTTTTTTTTTCCTCTGTCCATGTGCCATTTTTTAACTGAT
ACGCTTGCTAGAGAGTTCAGCTAGTCGGAACGCCAGGGAAAGGCGACAGAAGTTGGTGGCCCCA
CGTTATTGCATAAGCTAAAGCAGCAAACACCCCCAGGCGAAGTTTTCTCTTGTTTGTGAATAGC
CCTTGCAGAGTTTGTAAATCAGCAGATGGCTCCCCGACCCCTCCTTGTTTTCTCCAGAGATAAT
GTGCTATATTTTTGTATATACGATAATATTTGCAACTGTGAAAAAAAACCAAGTTGTGCTATAC
TCCCGTGGCACAGTCACAAAATATTATACTAATATGCTGTACATTCGGAAGAATGTGACGATCG
GTATGTTTTAGATTGTATTTTGCCTTACAGGAAGCCTTTATTGTAAGACGCTGACTTCCCTTTG
GACTTGATGTATATTGTACAGTTACAGTAAAATTCAACCTTTATTTTCTAATTTTTTCAACATA
TTGTTTAGTGTAAAGAATATTTATTTGAAGTTTTATTATTTTATAAAAAAAGAATATTTATTTT
AAGAGGCATCATAAATTTTGCCCCTTTTATGAGGATGTGAGGGTTGCTGCAAAGGAGAGGTTAC
AGATGCTATGTTCAATATAAAATAGAAAATATATTAACGTTTGAAATTAAACTGACCTTGTTTT
GTCTTGTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001012046	(Get FASTA)	NCBI Sequence Viewer
	XP_006252500	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89116	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001012046 ⟸ NM_001012046

- UniProtKB:

Q5HZA2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEARAQSGSGSQPLLQSPHDSGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPR
PGLKPAPRPSTQHKHERLHGLPEHRQPPRLQPTQVHSSRAALSRSVSTVSSGSRSSTRTSTSSS
SSEQRLLGSSFSPGPAVDGIIRVQPKSELKSGELKPLSRDDLGLHAYRCEDCGKCKCKECTYPR
PLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMG
VMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT

hide sequence

RefSeq Acc Id:	XP_006252500 ⟸ XM_006252438
- Peptide Label:	isoform X1
- UniProtKB:	Q5HZA2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEARAQSGSGSQPLLQSPHDSGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPR PGLKPAPRPSTQHKHERLHGLPEHRQPPRLQPTQVHSSRAALSRSVSTVSSGSRSSTRTSTSSS SSEQRLLGSSFSPGPAVDGIIRVQPKSELKSGELKPLSRDDLGLHAYRCEDCGKCKCKECTYPR PLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMG VMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT hide sequence

RefSeq Acc Id:

ENSRNOP00000013342 ⟸ ENSRNOT00000013342

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311472	AgrOrtholog
Ensembl Genes	ENSRNOG00000010058	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000013342	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013342	ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7320532	IMAGE-MGC_LOAD
InterPro	Sprouty	UniProtKB/TrEMBL
	SPRY2	UniProtKB/TrEMBL
KEGG Report	rno:306141	UniProtKB/TrEMBL
MGC_CLONE	MGC:105639	IMAGE-MGC_LOAD
NCBI Gene	306141	ENTREZGENE
PANTHER	PTHR12365:SF8	UniProtKB/TrEMBL
Pfam	Sprouty	UniProtKB/TrEMBL
PhenoGen	Spry2	PhenoGen
PROSITE	SPR	UniProtKB/TrEMBL
UniProt	Q5HZA2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-01	Spry2	sprouty RTK signaling antagonist 2	Spry2	sprouty homolog 2 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Spry2	sprouty homolog 2 (Drosophila)	Spry2_predicted	sprouty homolog 2 (Drosophila) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Spry2_predicted	sprouty homolog 2 (Drosophila) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)