Spry2 (sprouty RTK signaling antagonist 2) - Rat Genome Database
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Gene: Spry2 (sprouty RTK signaling antagonist 2) Rattus norvegicus
Analyze
Symbol: Spry2
Name: sprouty RTK signaling antagonist 2
RGD ID: 1311472
Description: Predicted to have protein kinase binding activity and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including lung development; regulation of protein phosphorylation; and regulation of signal transduction. Predicted to localize to several cellular components, including cytoskeleton; cytosol; and nucleus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2); PARTICIPATES IN fibroblast growth factor signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; dibutyl phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC306141; sprouty 2; sprouty homolog 2; sprouty homolog 2 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21582,692,312 - 82,697,408 (-)NCBI
Rnor_6.0 Ensembl1590,172,975 - 90,175,802 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01590,172,769 - 90,177,823 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01593,662,768 - 93,667,781 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41590,009,109 - 90,011,940 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11590,024,884 - 90,027,720 (-)NCBI
Celera1581,798,483 - 81,801,309 (-)NCBICelera
Cytogenetic Map15q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
formaldehyde  (ISO)
furan  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
isobutanol  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitrofen  (EXP)
paracetamol  (ISO)
PD 0325901  (ISO)
phenobarbital  (ISO)
phorone  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
Tesaglitazar  (EXP)
thapsigargin  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IBA)
branching morphogenesis of an epithelial tube  (ISO)
bud elongation involved in lung branching  (ISO)
cell fate commitment  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
establishment of mitotic spindle orientation  (ISO)
inner ear morphogenesis  (ISO)
lung development  (ISO)
lung growth  (ISO)
lung morphogenesis  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell projection organization  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (IBA,ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of lens fiber cell differentiation  (ISO)
negative regulation of MAP kinase activity  (IBA,ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (ISO)
negative regulation of protein ubiquitination  (IEA,ISO)
negative regulation of Ras protein signal transduction  (IBA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of vascular endothelial growth factor signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein serine/threonine kinase activity  (IEA)
respiratory system development  (ISO)
sensory perception of sound  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10074434   PMID:11287183   PMID:11585837   PMID:12477932   PMID:15809037   PMID:16339969   PMID:16893902   PMID:17141539   PMID:17255109   PMID:18070883   PMID:18508928   PMID:19683577  
PMID:20029031   PMID:20439489   PMID:20489163   PMID:20736167   PMID:21536891   PMID:21764747   PMID:22236546   PMID:23982388   PMID:24177325   PMID:24210189   PMID:24469046   PMID:25822989  
PMID:29409968  


Genomics

Comparative Map Data
Spry2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21582,692,312 - 82,697,408 (-)NCBI
Rnor_6.0 Ensembl1590,172,975 - 90,175,802 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01590,172,769 - 90,177,823 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01593,662,768 - 93,667,781 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41590,009,109 - 90,011,940 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11590,024,884 - 90,027,720 (-)NCBI
Celera1581,798,483 - 81,801,309 (-)NCBICelera
Cytogenetic Map15q22NCBI
SPRY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1380,335,976 - 80,341,126 (-)EnsemblGRCh38hg38GRCh38
GRCh381380,335,976 - 80,341,126 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371380,910,111 - 80,915,261 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371380,910,111 - 80,915,086 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361379,808,112 - 79,813,087 (-)NCBINCBI36hg18NCBI36
Build 341379,808,114 - 79,813,087NCBI
Celera1361,811,860 - 61,816,835 (-)NCBI
Cytogenetic Map13q31.1NCBI
HuRef1361,613,784 - 61,618,759 (-)NCBIHuRef
CHM1_11380,877,733 - 80,882,872 (-)NCBICHM1_1
Spry2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914106,129,381 - 106,134,899 (-)NCBIGRCm39mm39
GRCm3814105,891,947 - 105,896,819 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14105,891,947 - 105,896,819 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714106,291,164 - 106,296,036 (-)NCBIGRCm37mm9NCBIm37
MGSCv3614104,778,114 - 104,782,418 (-)NCBImm8
Celera14104,512,649 - 104,517,512 (-)NCBICelera
Cytogenetic Map14E2.3NCBI
cM Map1456.16NCBI
Spry2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540427,349,519 - 27,353,706 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540427,349,286 - 27,353,706 (+)NCBIChiLan1.0ChiLan1.0
SPRY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11380,595,679 - 80,600,670 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1380,596,346 - 80,597,408 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01361,569,658 - 61,574,817 (-)NCBIMhudiblu_PPA_v0panPan3
SPRY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2233,366,931 - 33,367,878 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12233,366,139 - 33,371,102 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Spry2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365111,452,421 - 1,458,031 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPRY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1152,153,704 - 52,160,497 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11152,153,695 - 52,158,766 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21156,943,755 - 56,948,261 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPRY2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1359,357,611 - 59,362,705 (-)NCBI
ChlSab1.1 Ensembl359,358,394 - 59,359,341 (-)Ensembl
Spry2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475120,091,612 - 20,096,581 (+)NCBI

Position Markers
RH143991  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01590,173,234 - 90,173,382NCBIRnor6.0
Rnor_5.01593,663,212 - 93,663,360UniSTSRnor5.0
RGSC_v3.41590,009,372 - 90,009,520UniSTSRGSC3.4
Celera1581,798,746 - 81,798,894UniSTS
RH 3.4 Map15551.19UniSTS
Cytogenetic Map15q22UniSTS
RH44769  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01590,177,392 - 90,177,655NCBIRnor6.0
Rnor_5.01593,667,370 - 93,667,633UniSTSRnor5.0
RGSC_v3.41590,013,530 - 90,013,793UniSTSRGSC3.4
Celera1581,802,899 - 81,803,162UniSTS
Cytogenetic Map15q22UniSTS
BQ201059  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01590,173,785 - 90,173,980NCBIRnor6.0
Rnor_5.01593,663,763 - 93,663,958UniSTSRnor5.0
RGSC_v3.41590,009,923 - 90,010,118UniSTSRGSC3.4
Celera1581,799,297 - 81,799,487UniSTS
RH 3.4 Map15551.0UniSTS
Cytogenetic Map15q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1526381041106550657Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1526381041106550657Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1526381041106550657Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1543097470106550657Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)1561447766106447766Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)156259641099372139Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1562596410103164962Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1565520564110520564Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1575527634111246239Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1575761024109400896Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1581255292103165069Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1581255292109133904Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)1581255430103164962Rat
1581555Eae19Experimental allergic encephalomyelitis QTL 194.7nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)158394771498027710Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1583947714111246239Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1584050550111246239Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1584050550111246239Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1589640684106550657Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)1589640684106550657Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:354
Count of miRNA genes:211
Interacting mature miRNAs:248
Transcripts:ENSRNOT00000013342
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 7 6 4 6 1 4 74 30 33 11 1
Low 7 50 35 15 35 7 7 5 8 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013342   ⟹   ENSRNOP00000013342
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1590,172,975 - 90,175,802 (-)Ensembl
RefSeq Acc Id: NM_001012046   ⟹   NP_001012046
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21582,692,493 - 82,695,324 (-)NCBI
Rnor_6.01590,172,971 - 90,175,802 (-)NCBI
Rnor_5.01593,662,768 - 93,667,781 (-)NCBI
RGSC_v3.41590,009,109 - 90,011,940 (-)RGD
Celera1581,798,483 - 81,801,309 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252438   ⟹   XP_006252500
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21582,692,312 - 82,697,408 (-)NCBI
Rnor_6.01590,172,769 - 90,177,823 (-)NCBI
Rnor_5.01593,662,768 - 93,667,781 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001012046 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252500 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89116 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001012046   ⟸   NM_001012046
- UniProtKB: Q5HZA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252500   ⟸   XM_006252438
- Peptide Label: isoform X1
- UniProtKB: Q5HZA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013342   ⟸   ENSRNOT00000013342

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311472 AgrOrtholog
Ensembl Genes ENSRNOG00000010058 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000013342 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013342 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7320532 IMAGE-MGC_LOAD
InterPro Sprouty UniProtKB/TrEMBL
  SPRY2 UniProtKB/TrEMBL
KEGG Report rno:306141 UniProtKB/TrEMBL
MGC_CLONE MGC:105639 IMAGE-MGC_LOAD
NCBI Gene 306141 ENTREZGENE
PANTHER PTHR12365:SF8 UniProtKB/TrEMBL
Pfam Sprouty UniProtKB/TrEMBL
PhenoGen Spry2 PhenoGen
PROSITE SPR UniProtKB/TrEMBL
UniProt Q5HZA2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Spry2  sprouty RTK signaling antagonist 2  Spry2  sprouty homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Spry2  sprouty homolog 2 (Drosophila)  Spry2_predicted  sprouty homolog 2 (Drosophila) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Spry2_predicted  sprouty homolog 2 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED