Spry2 (sprouty RTK signaling antagonist 2) - Rat Genome Database

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Gene: Spry2 (sprouty RTK signaling antagonist 2) Rattus norvegicus
Analyze
Symbol: Spry2
Name: sprouty RTK signaling antagonist 2
RGD ID: 1311472
Description: Predicted to enable protein kinase binding activity and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including negative regulation of cell differentiation; regulation of protein modification process; and regulation of signal transduction. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; lung development; and negative regulation of signal transduction. Predicted to be located in cytoskeleton; membrane; and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2); PARTICIPATES IN fibroblast growth factor signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC306141; sprouty 2; sprouty homolog 2; sprouty homolog 2 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21582,692,312 - 82,697,408 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1582,692,143 - 82,698,009 (-)Ensembl
Rnor_6.01590,172,769 - 90,177,823 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1590,172,975 - 90,175,802 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01593,662,768 - 93,667,781 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41590,009,109 - 90,011,940 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11590,024,884 - 90,027,720 (-)NCBI
Celera1581,798,483 - 81,801,309 (-)NCBICelera
Cytogenetic Map15q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
isobutanol  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitrofen  (EXP)
paracetamol  (ISO)
PD 0325901  (ISO)
phenobarbital  (ISO)
phorone  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
torcetrapib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IBA)
branching morphogenesis of an epithelial tube  (ISO)
bud elongation involved in lung branching  (ISO)
cell fate commitment  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
ERK1 and ERK2 cascade  (IEA,ISO)
establishment of mitotic spindle orientation  (ISO)
fibroblast growth factor receptor signaling pathway  (IEA,ISO)
inner ear morphogenesis  (ISO)
lung development  (ISO)
lung growth  (ISO)
lung morphogenesis  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell projection organization  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (IBA,ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of lens fiber cell differentiation  (ISO)
negative regulation of MAP kinase activity  (IBA,ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of Ras protein signal transduction  (IBA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of vascular endothelial growth factor signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein serine/threonine kinase activity  (IEA)
respiratory system development  (ISO)
sensory perception of sound  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10074434   PMID:11287183   PMID:11585837   PMID:12477932   PMID:15809037   PMID:16339969   PMID:16893902   PMID:17141539   PMID:17255109   PMID:18070883   PMID:18508928   PMID:19683577  
PMID:20029031   PMID:20439489   PMID:20489163   PMID:20736167   PMID:21536891   PMID:21764747   PMID:22236546   PMID:23982388   PMID:24177325   PMID:24210189   PMID:24469046   PMID:25822989  
PMID:29409968   PMID:33037124  


Genomics

Comparative Map Data
Spry2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21582,692,312 - 82,697,408 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1582,692,143 - 82,698,009 (-)Ensembl
Rnor_6.01590,172,769 - 90,177,823 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1590,172,975 - 90,175,802 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01593,662,768 - 93,667,781 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41590,009,109 - 90,011,940 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11590,024,884 - 90,027,720 (-)NCBI
Celera1581,798,483 - 81,801,309 (-)NCBICelera
Cytogenetic Map15q22NCBI
SPRY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381380,335,976 - 80,341,126 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1380,335,976 - 80,341,126 (-)EnsemblGRCh38hg38GRCh38
GRCh371380,910,111 - 80,915,261 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361379,808,112 - 79,813,087 (-)NCBINCBI36hg18NCBI36
Build 341379,808,114 - 79,813,087NCBI
Celera1361,811,860 - 61,816,835 (-)NCBI
Cytogenetic Map13q31.1NCBI
HuRef1361,613,784 - 61,618,759 (-)NCBIHuRef
CHM1_11380,877,733 - 80,882,708 (-)NCBICHM1_1
T2T-CHM13v2.01379,564,038 - 79,569,188 (-)NCBI
Spry2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914106,129,381 - 106,134,899 (-)NCBIGRCm39mm39
GRCm39 Ensembl14106,129,381 - 106,134,253 (-)Ensembl
GRCm3814105,891,947 - 105,896,819 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14105,891,947 - 105,896,819 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714106,291,164 - 106,296,036 (-)NCBIGRCm37mm9NCBIm37
MGSCv3614104,778,114 - 104,782,418 (-)NCBImm8
Celera14104,512,649 - 104,517,512 (-)NCBICelera
Cytogenetic Map14E2.3NCBI
cM Map1456.16NCBI
Spry2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540427,349,519 - 27,353,706 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540427,349,286 - 27,353,706 (+)NCBIChiLan1.0ChiLan1.0
SPRY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11380,595,679 - 80,600,670 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1380,596,346 - 80,597,408 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01361,569,658 - 61,574,817 (-)NCBIMhudiblu_PPA_v0panPan3
SPRY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12233,366,139 - 33,371,102 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2233,366,931 - 33,367,878 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2233,168,781 - 33,173,903 (-)NCBI
ROS_Cfam_1.02233,695,480 - 33,700,592 (-)NCBI
ROS_Cfam_1.0 Ensembl2233,695,481 - 33,700,517 (-)Ensembl
UMICH_Zoey_3.12233,352,773 - 33,357,889 (-)NCBI
UNSW_CanFamBas_1.02233,390,454 - 33,395,571 (-)NCBI
UU_Cfam_GSD_1.02233,464,090 - 33,469,216 (-)NCBI
Spry2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945126,035,217 - 126,040,822 (+)NCBI
SpeTri2.0NW_0049365111,452,421 - 1,458,031 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPRY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1152,153,704 - 52,160,497 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11152,153,695 - 52,158,766 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21156,943,755 - 56,948,261 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPRY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1359,357,611 - 59,362,705 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl359,358,394 - 59,359,341 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604615,625,484 - 15,630,748 (-)NCBIVero_WHO_p1.0
Spry2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475120,091,609 - 20,096,563 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475120,091,612 - 20,096,581 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH143991  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21582,692,755 - 82,692,904 (+)MAPPERmRatBN7.2
Rnor_6.01590,173,234 - 90,173,382NCBIRnor6.0
Rnor_5.01593,663,212 - 93,663,360UniSTSRnor5.0
RGSC_v3.41590,009,372 - 90,009,520UniSTSRGSC3.4
Celera1581,798,746 - 81,798,894UniSTS
RH 3.4 Map15551.19UniSTS
Cytogenetic Map15q22UniSTS
RH44769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21582,696,913 - 82,697,177 (+)MAPPERmRatBN7.2
Rnor_6.01590,177,392 - 90,177,655NCBIRnor6.0
Rnor_5.01593,667,370 - 93,667,633UniSTSRnor5.0
RGSC_v3.41590,013,530 - 90,013,793UniSTSRGSC3.4
Celera1581,802,899 - 81,803,162UniSTS
Cytogenetic Map15q22UniSTS
BQ201059  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21582,693,306 - 82,693,502 (+)MAPPERmRatBN7.2
Rnor_6.01590,173,785 - 90,173,980NCBIRnor6.0
Rnor_5.01593,663,763 - 93,663,958UniSTSRnor5.0
RGSC_v3.41590,009,923 - 90,010,118UniSTSRGSC3.4
Celera1581,799,297 - 81,799,487UniSTS
RH 3.4 Map15551.0UniSTS
Cytogenetic Map15q22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)155559608991365858Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)155559608995018120Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157369051895018228Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)157369065795018120Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
1581555Eae19Experimental allergic encephalomyelitis QTL 194.7nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)157630609990088744Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)158226252098288169Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)158226252098288169Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:354
Count of miRNA genes:211
Interacting mature miRNAs:248
Transcripts:ENSRNOT00000013342
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 7 6 4 6 1 4 74 30 33 11 1
Low 7 50 35 15 35 7 7 5 8 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013342   ⟹   ENSRNOP00000013342
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1582,692,497 - 82,695,324 (-)Ensembl
Rnor_6.0 Ensembl1590,172,975 - 90,175,802 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097462   ⟹   ENSRNOP00000077712
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1582,692,143 - 82,698,009 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106586   ⟹   ENSRNOP00000081271
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1582,692,347 - 82,695,917 (-)Ensembl
RefSeq Acc Id: NM_001012046   ⟹   NP_001012046
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21582,692,493 - 82,695,324 (-)NCBI
Rnor_6.01590,172,971 - 90,175,802 (-)NCBI
Rnor_5.01593,662,768 - 93,667,781 (-)NCBI
RGSC_v3.41590,009,109 - 90,011,940 (-)RGD
Celera1581,798,483 - 81,801,309 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252438   ⟹   XP_006252500
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21582,692,312 - 82,697,408 (-)NCBI
Rnor_6.01590,172,769 - 90,177,823 (-)NCBI
Rnor_5.01593,662,768 - 93,667,781 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001012046 (Get FASTA)   NCBI Sequence Viewer  
  NP_001380765 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252500 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89116 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001012046   ⟸   NM_001012046
- UniProtKB: Q5HZA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252500   ⟸   XM_006252438
- Peptide Label: isoform X1
- UniProtKB: Q5HZA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013342   ⟸   ENSRNOT00000013342
RefSeq Acc Id: ENSRNOP00000077712   ⟸   ENSRNOT00000097462
RefSeq Acc Id: ENSRNOP00000081271   ⟸   ENSRNOT00000106586

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5HZA2-F1-model_v2 AlphaFold Q5HZA2 1-314 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311472 AgrOrtholog
BioCyc Gene G2FUF-12613 BioCyc
Ensembl Genes ENSRNOG00000010058 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000013342 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000077712 ENTREZGENE
Ensembl Transcript ENSRNOT00000013342 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000097462 ENTREZGENE
IMAGE_CLONE IMAGE:7320532 IMAGE-MGC_LOAD
InterPro Sprouty UniProtKB/TrEMBL
  SPRY2 UniProtKB/TrEMBL
KEGG Report rno:306141 UniProtKB/TrEMBL
MGC_CLONE MGC:105639 IMAGE-MGC_LOAD
NCBI Gene 306141 ENTREZGENE
PANTHER PTHR12365:SF8 UniProtKB/TrEMBL
Pfam Sprouty UniProtKB/TrEMBL
PhenoGen Spry2 PhenoGen
PROSITE SPR UniProtKB/TrEMBL
UniProt Q5HZA2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Spry2  sprouty RTK signaling antagonist 2  Spry2  sprouty homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Spry2  sprouty homolog 2 (Drosophila)  Spry2_predicted  sprouty homolog 2 (Drosophila) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Spry2_predicted  sprouty homolog 2 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED