Gene: Spry2 (sprouty RTK signaling antagonist 2) Rattus norvegicus
Analyze
Symbol:
Spry2
Name:
sprouty RTK signaling antagonist 2
Description:
Predicted to have protein kinase binding activity and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including lung development; regulation of protein phosphorylation; and regulation of signal transduction. Predicted to localize to several cellular components, including the cytoskeleton; cytosol; and nucleus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2); PARTICIPATES IN fibroblast growth factor signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; dibutyl phthalate.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC306141; sprouty 2; sprouty homolog 2; sprouty homolog 2 (Drosophila)
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SPRY2 (sprouty RTK signaling antagonist 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Spry2 (sprouty RTK signaling antagonist 2) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Spry2 (sprouty RTK signaling antagonist 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SPRY2 (sprouty RTK signaling antagonist 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SPRY2 (sprouty RTK signaling antagonist 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Spry2 (sprouty RTK signaling antagonist 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SPRY2 (sprouty RTK signaling antagonist 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
SPRY2 (sprouty RTK signaling antagonist 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Spry2 (sprouty RTK signaling antagonist 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
spry2 (sprouty RTK signaling antagonist 2)
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
sty
Alliance
DIOPT (Ensembl Compara, OrthoInspector, PANTHER, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 15 90,172,769 - 90,177,823 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 15 90,172,975 - 90,175,802 (-) Ensembl Rnor_5.0 15 93,662,768 - 93,667,781 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 15 90,009,109 - 90,011,940 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 15 90,024,884 - 90,027,720 (-) NCBI Celera 15 81,798,483 - 81,801,309 (-) NCBI Celera Cytogenetic Map 15 q22 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
cleft lip ISO RGD:1322949 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17576140 cleft palate ISO RGD:1322949 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17576140 Craniofacial Abnormalities ISO RGD:1322949 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17576140 IgA glomerulonephritis ISO RGD:1322949 11554173 CTD Direct Evidence: marker/mechanism CTD lung disease ISO RGD:1322949 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24210189 Lung Neoplasms ISO RGD:1322949 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15136453
Imported Annotations - MGI
achalasia ISS RGD:1322950 13592920 OMIM:200400 MouseDO neuronal intestinal dysplasia ISS RGD:1322950 13592920 OMIM:243180 , OMIM:601223MouseDO Imported Annotations - OMIM
IgA glomerulonephritis susceptibility ISO RGD:1322949 7240710 OMIM
2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO RGD:1322949 6480464 2 more ... CTD PMID:19095052 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1322950 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SPRY2 promoter] CTD PMID:19654925 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SPRY2 mRNA CTD PMID:21215274 2-methylcholine affects expression ISO RGD:1322949 6480464 beta-methylcholine affects the expression of SPRY2 mRNA CTD PMID:21179406 3-methylcholanthrene increases expression ISO RGD:1322950 6480464 Methylcholanthrene results in increased expression of SPRY2 mRNA CTD PMID:20713471 4,4'-diaminodiphenylmethane decreases expression ISO RGD:1322950 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of SPRY2 mRNA CTD PMID:18648102 4-hydroxynon-2-enal decreases expression ISO RGD:1322949 6480464 4-hydroxy-2-nonenal results in decreased expression of SPRY2 mRNA CTD PMID:12419474 8-bromo-3',5'-cyclic AMP increases expression ISO RGD:1322949 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SPRY2 mRNA CTD PMID:22079614 acetaldehyde affects expression ISO RGD:1322950 6480464 Acetaldehyde affects the expression of SPRY2 mRNA CTD PMID:22634333 aldehydo-D-glucose increases expression ISO RGD:1322950 6480464 Glucose results in increased expression of SPRY2 mRNA CTD PMID:17178593 all-trans-retinoic acid affects expression ISO RGD:1322949 6480464 Tretinoin affects the expression of SPRY2 mRNA CTD PMID:15498508 all-trans-retinoic acid decreases expression ISO RGD:1322949 6480464 Tretinoin results in decreased expression of SPRY2 mRNA CTD PMID:23724009 arsane affects methylation ISO RGD:1322949 6480464 Arsenic affects the methylation of SPRY2 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1322949 6480464 Arsenic affects the methylation of SPRY2 gene CTD PMID:25304211 arsenite(3-) decreases expression ISO RGD:1322949 6480464 arsenite results in decreased expression of SPRY2 protein CTD PMID:22387281 atrazine decreases expression ISO RGD:1322949 6480464 Atrazine results in decreased expression of SPRY2 mRNA CTD PMID:22378314 bisphenol A affects expression ISO RGD:1322949 6480464 bisphenol A affects the expression of SPRY2 mRNA CTD PMID:20170705 bisphenol A decreases expression ISO RGD:1322949 6480464 bisphenol A results in decreased expression of SPRY2 mRNA CTD PMID:29275510 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of SPRY2 gene CTD PMID:28505145 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SPRY2 mRNA CTD PMID:25181051 calcitriol increases expression ISO RGD:1322949 6480464 Calcitriol results in increased expression of SPRY2 mRNA CTD PMID:16002434 carbamazepine affects expression ISO RGD:1322950 6480464 Carbamazepine affects the expression of SPRY2 mRNA CTD PMID:22634333 cisplatin multiple interactions ISO RGD:1322949 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of SPRY2 mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:1322949 6480464 Cisplatin results in decreased expression of SPRY2 mRNA CTD PMID:27392435 cobalt dichloride decreases expression ISO RGD:1322949 6480464 cobaltous chloride results in decreased expression of SPRY2 mRNA CTD PMID:19320972 copper(II) sulfate decreases expression ISO RGD:1322949 6480464 Copper Sulfate results in decreased expression of SPRY2 mRNA CTD PMID:19549813 crocidolite asbestos increases expression ISO RGD:1322949 6480464 Asbestos, Crocidolite results in increased expression of SPRY2 mRNA CTD PMID:18687144 crocidolite asbestos increases methylation ISO RGD:1322949 6480464 Asbestos, Crocidolite results in increased methylation of SPRY2 gene CTD PMID:29523930 crocidolite asbestos affects expression ISO RGD:1322949 6480464 Asbestos, Crocidolite affects the expression of SPRY2 mRNA CTD PMID:25757056 cyclosporin A increases expression ISO RGD:1322949 6480464 Cyclosporine results in increased expression of SPRY2 mRNA CTD PMID:20106945 cyproconazole decreases expression ISO RGD:1322950 6480464 cyproconazole results in decreased expression of SPRY2 mRNA CTD PMID:22045034 D-glucose increases expression ISO RGD:1322950 6480464 Glucose results in increased expression of SPRY2 mRNA CTD PMID:17178593 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of SPRY2 mRNA CTD PMID:21266533 dibutyl phthalate increases expression ISO RGD:1322950 6480464 Dibutyl Phthalate results in increased expression of SPRY2 mRNA CTD PMID:17361019 , PMID:21266533 dioxygen multiple interactions ISO RGD:1322949 6480464 Oxygen deficiency promotes the reaction [KDM3A protein binds to SPRY2 promoter] CTD PMID:20881000 dioxygen decreases expression ISO RGD:1322949 6480464 Oxygen deficiency results in decreased expression of SPRY2 mRNA, Oxygen deficiency results in decreased expression of SPRY2 protein CTD PMID:20881000 ethanol affects expression ISO RGD:1322950 6480464 Ethanol affects the expression of SPRY2 mRNA CTD PMID:30319688 ethyl methanesulfonate decreases expression ISO RGD:1322949 6480464 Ethyl Methanesulfonate results in decreased expression of SPRY2 mRNA CTD PMID:23649840 fluoranthene multiple interactions ISO RGD:1322950 6480464 [1-methylanthracene co-treated with fluoranthene] results in increased expression of SPRY2 mRNA CTD PMID:28329830 fluoxetine affects expression ISO RGD:1322950 6480464 Fluoxetine affects the expression of SPRY2 mRNA CTD PMID:29893963 flusilazole affects expression ISO RGD:1322950 6480464 flusilazole affects the expression of SPRY2 mRNA CTD PMID:22634333 formaldehyde decreases expression ISO RGD:1322949 6480464 Formaldehyde results in decreased expression of SPRY2 mRNA CTD PMID:20655997 furan increases expression EXP 6480464 furan results in increased expression of SPRY2 mRNA CTD PMID:27387713 glucose increases expression ISO RGD:1322950 6480464 Glucose results in increased expression of SPRY2 mRNA CTD PMID:17178593 hydrogen peroxide affects expression ISO RGD:1322949 6480464 Hydrogen Peroxide affects the expression of SPRY2 mRNA CTD PMID:20044591 hydrogen peroxide decreases expression ISO RGD:1322949 6480464 Hydrogen Peroxide results in decreased expression of SPRY2 mRNA CTD PMID:12419474 isobutanol multiple interactions ISO RGD:1322949 6480464 [[Gasoline co-treated with isobutyl alcohol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SPRY2 mRNA CTD PMID:29432896 lead diacetate decreases expression ISO RGD:1322950 6480464 lead acetate results in decreased expression of SPRY2 mRNA CTD PMID:22609695 leflunomide increases expression ISO RGD:1322949 6480464 leflunomide results in increased expression of SPRY2 mRNA CTD PMID:28988120 menadione affects expression ISO RGD:1322949 6480464 Vitamin K 3 affects the expression of SPRY2 mRNA CTD PMID:20044591 menadione decreases expression ISO RGD:1322950 6480464 Vitamin K 3 results in decreased expression of SPRY2 mRNA CTD PMID:25270620 methyl methanesulfonate decreases expression ISO RGD:1322949 6480464 Methyl Methanesulfonate results in decreased expression of SPRY2 mRNA CTD PMID:23649840 methylmercury chloride increases expression ISO RGD:1322949 6480464 methylmercuric chloride results in increased expression of SPRY2 mRNA CTD PMID:28001369 N-methyl-N-nitrosourea increases expression EXP 6480464 Methylnitrosourea results in increased expression of SPRY2 mRNA CTD PMID:17412507 N-nitrosodiethylamine increases expression ISO RGD:1322950 6480464 Diethylnitrosamine results in increased expression of SPRY2 mRNA CTD PMID:24535843 nickel atom multiple interactions ISO RGD:1322949 6480464 SPRY2 mRNA affects the reaction [Nickel results in increased phosphorylation of MAPK1 protein] more ... CTD PMID:20881000 nickel atom decreases expression ISO RGD:1322949 6480464 Nickel results in decreased expression of SPRY2 mRNA, Nickel results in decreased expression of SPRY2 protein CTD PMID:20881000 nickel dichloride multiple interactions ISO RGD:1322949 6480464 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [nickel chloride results in decreased expression of SPRY2 protein] more ... CTD PMID:26026961 nickel dichloride decreases expression ISO RGD:1322949 6480464 nickel chloride results in decreased expression of SPRY2 protein CTD PMID:26026961 nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of SPRY2 mRNA CTD PMID:23982388 , PMID:24210189 nitrofen multiple interactions EXP 6480464 nitrofen results in decreased expression of and results in decreased phosphorylation of SPRY2 protein CTD PMID:24210189 paracetamol affects expression ISO RGD:1322950 6480464 Acetaminophen affects the expression of SPRY2 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:1322949 6480464 Acetaminophen results in increased expression of SPRY2 mRNA CTD PMID:26690555 , PMID:29067470 PD 0325901 multiple interactions ISO RGD:1322949 6480464 [PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SPRY2 mRNA CTD PMID:25119042 PD 0325901 decreases expression ISO RGD:1322949 6480464 PD 0325901 results in decreased expression of SPRY2 mRNA CTD PMID:25119042 phenobarbital affects expression ISO RGD:1322949 6480464 Phenobarbital affects the expression of SPRY2 mRNA CTD PMID:19159669 phorone affects expression EXP 6480464 phorone affects the expression of SPRY2 mRNA CTD PMID:18198479 pirinixic acid increases expression ISO RGD:1322950 6480464 pirinixic acid results in increased expression of SPRY2 mRNA CTD PMID:17426115 potassium chromate decreases expression ISO RGD:1322949 6480464 potassium chromate(VI) results in decreased expression of SPRY2 mRNA CTD PMID:22714537 silver atom decreases expression ISO RGD:1322950 6480464 Silver results in decreased expression of SPRY2 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:1322950 6480464 Silver results in decreased expression of SPRY2 mRNA CTD PMID:27131904 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of SPRY2 mRNA CTD PMID:19072884 Soman increases expression EXP 6480464 Soman results in increased expression of SPRY2 mRNA CTD PMID:19281266 succimer multiple interactions ISO RGD:1322949 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SPRY2 mRNA CTD PMID:26378955 tamibarotene increases expression ISO RGD:1322949 6480464 tamibarotene results in increased expression of SPRY2 mRNA CTD PMID:15498508 tamoxifen affects expression ISO RGD:1322950 6480464 Tamoxifen affects the expression of SPRY2 mRNA CTD PMID:20937368 taurine increases expression ISO RGD:1322949 6480464 Taurine results in increased expression of SPRY2 mRNA CTD PMID:16579726 Tesaglitazar decreases expression EXP 6480464 tesaglitazar results in decreased expression of SPRY2 mRNA CTD PMID:21515302 thapsigargin decreases expression ISO RGD:1322949 6480464 Thapsigargin results in decreased expression of SPRY2 mRNA CTD PMID:22378314 torcetrapib increases expression ISO RGD:1322949 6480464 torcetrapib results in increased expression of SPRY2 mRNA CTD PMID:23228038 trichostatin A decreases expression ISO RGD:1322949 6480464 trichostatin A results in decreased expression of SPRY2 mRNA CTD PMID:26272509 trimellitic anhydride decreases expression ISO RGD:1322950 6480464 trimellitic anhydride results in decreased expression of SPRY2 mRNA CTD PMID:19042947 tunicamycin decreases expression ISO RGD:1322949 6480464 Tunicamycin results in decreased expression of SPRY2 mRNA CTD PMID:22378314 , PMID:29453283 urethane increases expression ISO RGD:1322949 6480464 Urethane results in increased expression of SPRY2 mRNA CTD PMID:28818685 valproic acid decreases expression ISO RGD:1322950 6480464 Valproic Acid results in decreased expression of SPRY2 mRNA CTD PMID:21427059 , PMID:22045034 valproic acid decreases expression ISO RGD:1322949 6480464 Valproic Acid results in decreased expression of SPRY2 mRNA CTD PMID:23179753 more ... valproic acid increases expression ISO RGD:1322949 6480464 Valproic Acid results in increased expression of SPRY2 mRNA CTD PMID:24935251 , PMID:28001369 valproic acid affects expression ISO RGD:1322949 6480464 Valproic Acid affects the expression of SPRY2 mRNA CTD PMID:25979313 valsartan multiple interactions ISO RGD:1322949 6480464 Valsartan inhibits the reaction [AGT protein results in increased expression of SPRY2 mRNA] CTD PMID:19225232 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of SPRY2 mRNA CTD PMID:23034163 vorinostat decreases expression ISO RGD:1322949 6480464 vorinostat results in decreased expression of SPRY2 mRNA CTD PMID:27188386
Biological Process animal organ development IBA MGI:MGI:1345138 , PANTHER:PTN000961788 13792537 PMID:21873635 GO_Central branching morphogenesis of an epithelial tube ISO RGD:1322950 1624291 (MGI:MGI:1331548, PMID:10074434) RGD MGI:MGI:1331548 , PMID:10074434 bud elongation involved in lung branching ISO RGD:1322950 1624291 MGI:MGI:1099809 more ... RGD MGI:MGI:5052190 , PMID:21764747 bud elongation involved in lung branching IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell fate commitment ISO RGD:1322950 1624291 MGI:MGI:3578633 more ... RGD MGI:MGI:3577817 , PMID:15809037 cell fate commitment IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to leukemia inhibitory factor ISO RGD:1322950 1624291 (MGI:MGI:4822296, PMID:20439489) RGD MGI:MGI:4822296 , PMID:20439489 cellular response to leukemia inhibitory factor IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to vascular endothelial growth factor stimulus IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to vascular endothelial growth factor stimulus ISO RGD:1322949 1624291 (PMID:21536891) RGD PMID:21536891 establishment of mitotic spindle orientation ISO RGD:1322950 1624291 MGI:MGI:1099809 more ... RGD MGI:MGI:5052190 , PMID:21764747 establishment of mitotic spindle orientation IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 inner ear morphogenesis ISO RGD:1322950 1624291 MGI:MGI:3578633 more ... RGD MGI:MGI:3577817 , PMID:15809037 inner ear morphogenesis IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 lung development ISO RGD:1322950 1624291 (MGI:MGI:1331548, PMID:10074434) RGD MGI:MGI:1331548 , PMID:10074434 lung growth ISO RGD:1322950 1624291 (MGI:MGI:1934408, PMID:11287183) RGD MGI:MGI:1934408 , PMID:11287183 lung growth IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 lung morphogenesis ISO RGD:1322950 1624291 (MGI:MGI:1934408, PMID:11287183) RGD MGI:MGI:1934408 , PMID:11287183 negative regulation of angiogenesis ISO RGD:1322949 1624291 (PMID:24177325) RGD PMID:24177325 negative regulation of angiogenesis IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of apoptotic process ISO RGD:1322949 1624291 (PMID:18070883) RGD PMID:18070883 negative regulation of apoptotic process IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of apoptotic process IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of apoptotic process ISO RGD:1322950 1624291 (MGI:MGI:3773987, PMID:18070883) RGD MGI:MGI:3773987 , PMID:18070883 negative regulation of cell population proliferation ISO RGD:1322950 1624291 (MGI:MGI:2154590, PMID:11585837) RGD MGI:MGI:2154590 , PMID:11585837 negative regulation of cell population proliferation IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cell projection organization ISO RGD:1322950 1624291 (MGI:MGI:5693366, PMID:18508928) RGD MGI:MGI:5693366 , PMID:18508928 negative regulation of cell projection organization IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of ERK1 and ERK2 cascade ISO RGD:1322950 1624291 MGI:MGI:1099809 more ... RGD MGI:MGI:2154590 more ... negative regulation of ERK1 and ERK2 cascade ISO RGD:1322949 1624291 (PMID:20489163), (PMID:21536891) RGD PMID:20489163 , PMID:21536891 negative regulation of ERK1 and ERK2 cascade IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of ERK1 and ERK2 cascade IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of fibroblast growth factor receptor signaling pathway ISO RGD:1322950 1624291 MGI:MGI:99604 (MGI:MGI:2154590 more ... RGD MGI:MGI:2154590 more ... negative regulation of fibroblast growth factor receptor signaling pathway IBA FB:FBgn0014388 more ... 13792537 PMID:21873635 GO_Central negative regulation of fibroblast growth factor receptor signaling pathway IBA FB:FBgn0014388 more ... 13792537 PMID:21873635 GO_Central negative regulation of GTPase activity ISO RGD:1322950 1624291 (MGI:MGI:2154590, PMID:11585837) RGD MGI:MGI:2154590 , PMID:11585837 negative regulation of GTPase activity IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of MAP kinase activity ISO RGD:1322950 1624291 (MGI:MGI:3614383, PMID:16339969) RGD MGI:MGI:3614383 , PMID:16339969 negative regulation of MAP kinase activity IBA MGI:MGI:1345138 more ... 13792537 PMID:21873635 GO_Central negative regulation of neurotrophin TRK receptor signaling pathway ISO RGD:1322950 1624291 (MGI:MGI:2154590, PMID:11585837) RGD MGI:MGI:2154590 , PMID:11585837 negative regulation of neurotrophin TRK receptor signaling pathway IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of peptidyl-threonine phosphorylation ISO RGD:1322949 1624291 (PMID:20736167) RGD PMID:20736167 negative regulation of peptidyl-threonine phosphorylation IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of Ras protein signal transduction ISO RGD:1322950 1624291 (MGI:MGI:2154590, PMID:11585837) RGD MGI:MGI:2154590 , PMID:11585837 negative regulation of Ras protein signal transduction IBA MGI:MGI:1345138 more ... 13792537 PMID:21873635 GO_Central negative regulation of vascular endothelial growth factor signaling pathway IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of vascular endothelial growth factor signaling pathway ISO RGD:1322949 1624291 (PMID:21536891) RGD PMID:21536891 positive regulation of cell migration ISO RGD:1322949 1624291 (PMID:20489163) RGD PMID:20489163 positive regulation of cell migration IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of ERK1 and ERK2 cascade ISO RGD:1322949 1624291 (PMID:18070883) RGD PMID:18070883 positive regulation of ERK1 and ERK2 cascade IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of gene expression ISO RGD:1322949 1624291 (PMID:18070883) RGD PMID:18070883 positive regulation of gene expression IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of peptidyl-serine phosphorylation ISO RGD:1322949 1624291 (PMID:18070883) RGD PMID:18070883 positive regulation of peptidyl-serine phosphorylation IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of protein kinase B signaling ISO RGD:1322949 1624291 (PMID:18070883) RGD PMID:18070883 positive regulation of protein kinase B signaling IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of protein serine/threonine kinase activity IEA GO:0043539 1600115 GO_REF:0000108 GOC GO_REF:0000108 regulation of cell differentiation IEA InterPro:IPR030780 1600115 GO_REF:0000002 InterPro GO_REF:0000002 respiratory system development ISO RGD:1322950 1624291 (MGI:MGI:1934408, PMID:11287183) RGD MGI:MGI:1934408 , PMID:11287183 sensory perception of sound ISO RGD:1322950 1624291 MGI:MGI:3578633 (MGI:MGI:3577817 , PMID:15809037) RGD MGI:MGI:3577817 , PMID:15809037 sensory perception of sound IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component actin cytoskeleton ISO RGD:1322949 1624291 RGD GO_REF:0000052 actin cytoskeleton IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell IEA GO:0000132 1600115 GO_REF:0000108 GOC GO_REF:0000108 cytoskeleton ISO RGD:1322950 1624291 (MGI:MGI:5693366, PMID:18508928) RGD MGI:MGI:5693366 , PMID:18508928 cytosol ISO RGD:1322950 1624291 (MGI:MGI:5693366, PMID:18508928) RGD MGI:MGI:5693366 , PMID:18508928 cytosol IBA MGI:MGI:1345138 more ... 13792537 PMID:21873635 GO_Central membrane ISO RGD:1322950 1624291 (MGI:MGI:5693366, PMID:18508928) RGD MGI:MGI:5693366 , PMID:18508928 membrane IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 microtubule cytoskeleton IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 microtubule cytoskeleton ISO RGD:1322949 1624291 RGD GO_REF:0000052 microtubule end ISO RGD:1322949 1624291 RGD GO_REF:0000052 microtubule end IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:1322950 1624291 (MGI:MGI:5693366, PMID:18508928) RGD MGI:MGI:5693366 , PMID:18508928 nucleus IEA UniProtKB:Q9QXV8 , ensembl:ENSMUSP000000227091600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function protein binding ISO RGD:1322950 1624291 UniProtKB:Q3UUD2 more ... RGD MGI:MGI:2154590 more ... protein binding ISO RGD:1322949 1624291 UniProtKB:O43559 more ... RGD PMID:12815057 more ... protein kinase binding ISO RGD:1322949 1624291 UniProtKB:Q61214 (PMID:20736167) RGD PMID:20736167 protein kinase binding IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein serine/threonine kinase activator activity ISO RGD:1322949 1624291 (PMID:18070883) RGD PMID:18070883 protein serine/threonine kinase activator activity IEA UniProtKB:O43597 , ensembl:ENSP000003663061600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
