SPRY2 (sprouty RTK signaling antagonist 2) - Rat Genome Database

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Gene: SPRY2 (sprouty RTK signaling antagonist 2) Pan paniscus
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Symbol: SPRY2
Name: sprouty RTK signaling antagonist 2
RGD ID: 11818887
Description: ENCODES a protein that exhibits molecular function inhibitor activity (inferred); protein kinase binding (inferred); protein serine/threonine kinase activator activity (inferred); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); bud elongation involved in lung branching (ortholog); cell fate commitment (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; ASSOCIATED WITH achalasia (ortholog); chromosome 13q14 deletion syndrome (ortholog); ciliopathy (ortholog); FOUND IN actin cytoskeleton (inferred); cytoplasm (inferred); cytoskeleton (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sprouty homolog 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21481,917,809 - 81,922,593 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11380,512,191 - 80,517,659 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01361,569,658 - 61,574,817 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11380,595,679 - 80,600,670 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1380,596,346 - 80,597,408 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IEA)
branching morphogenesis of an epithelial tube  (IEA,ISO)
bud elongation involved in lung branching  (IEA,ISO)
cell fate commitment  (IEA,ISO)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cellular response to vascular endothelial growth factor stimulus  (IEA)
ERK1 and ERK2 cascade  (IEA,ISO)
establishment of mitotic spindle orientation  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IEA,ISO)
inner ear morphogenesis  (IEA,ISO)
lung development  (IEA,ISO)
lung growth  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
negative regulation of angiogenesis  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cell projection organization  (IEA)
negative regulation of epithelial to mesenchymal transition  (IEA)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (IEA,ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of lens fiber cell differentiation  (IEA)
negative regulation of MAP kinase activity  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (IEA,ISO)
negative regulation of protein ubiquitination  (IEA)
negative regulation of Ras protein signal transduction  (IEA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA)
negative regulation of vascular endothelial growth factor signaling pathway  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
regulation of signal transduction  (IEA)
respiratory system development  (IEA,ISO)
sensory perception of sound  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SPRY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21481,917,809 - 81,922,593 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11380,512,191 - 80,517,659 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01361,569,658 - 61,574,817 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11380,595,679 - 80,600,670 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1380,596,346 - 80,597,408 (-)Ensemblpanpan1.1panPan2
SPRY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381380,335,976 - 80,341,126 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1380,335,976 - 80,341,126 (-)EnsemblGRCh38hg38GRCh38
GRCh371380,910,111 - 80,915,261 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361379,808,112 - 79,813,087 (-)NCBINCBI36Build 36hg18NCBI36
Build 341379,808,114 - 79,813,087NCBI
Celera1361,811,860 - 61,816,835 (-)NCBICelera
Cytogenetic Map13q31.1NCBI
HuRef1361,613,784 - 61,618,759 (-)NCBIHuRef
CHM1_11380,877,733 - 80,882,708 (-)NCBICHM1_1
T2T-CHM13v2.01379,564,038 - 79,569,188 (-)NCBIT2T-CHM13v2.0
Spry2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914106,129,381 - 106,134,559 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14106,129,381 - 106,134,253 (-)EnsemblGRCm39 Ensembl
GRCm3814105,891,947 - 105,896,819 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14105,891,947 - 105,896,819 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714106,291,164 - 106,296,036 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614104,778,114 - 104,782,418 (-)NCBIMGSCv36mm8
Celera14104,512,649 - 104,517,512 (-)NCBICelera
Cytogenetic Map14E2.3NCBI
cM Map1456.16NCBI
Spry2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81589,106,809 - 89,111,926 (-)NCBIGRCr8
mRatBN7.21582,692,291 - 82,697,408 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1582,692,143 - 82,698,009 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1586,673,206 - 86,678,322 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01587,788,634 - 87,793,751 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01584,721,558 - 84,726,674 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01590,172,769 - 90,177,823 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1590,172,975 - 90,175,802 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01593,662,768 - 93,667,781 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41590,009,109 - 90,011,940 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11590,024,884 - 90,027,720 (-)NCBI
Celera1581,798,483 - 81,801,309 (-)NCBICelera
Cytogenetic Map15q22NCBI
Spry2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540427,349,519 - 27,353,706 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540427,349,286 - 27,353,706 (+)NCBIChiLan1.0ChiLan1.0
SPRY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12233,366,139 - 33,371,102 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2233,366,931 - 33,367,878 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2233,168,781 - 33,173,903 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02233,695,480 - 33,700,592 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2233,695,481 - 33,700,517 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12233,352,773 - 33,357,889 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02233,390,454 - 33,395,571 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02233,464,090 - 33,469,216 (-)NCBIUU_Cfam_GSD_1.0
Spry2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945126,035,217 - 126,040,822 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365111,452,807 - 1,458,031 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365111,452,421 - 1,458,031 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPRY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1152,153,704 - 52,159,156 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11152,153,695 - 52,158,766 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21156,943,755 - 56,948,261 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPRY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1359,357,611 - 59,362,705 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl359,358,394 - 59,359,341 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604615,625,484 - 15,630,748 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spry2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475120,091,609 - 20,096,563 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475120,091,612 - 20,096,581 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000047364   ⟹   ENSPPAP00000024539
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1380,596,346 - 80,597,408 (-)Ensembl
RefSeq Acc Id: XM_003825255   ⟹   XP_003825303
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21481,917,809 - 81,922,593 (-)NCBI
NHGRI_mPanPan11380,512,191 - 80,517,659 (-)NCBI
Mhudiblu_PPA_v01361,569,658 - 61,574,817 (-)NCBI
PanPan1.11380,595,679 - 80,600,670 (-)NCBI
Sequence:
RefSeq Acc Id: XM_057299601   ⟹   XP_057155584
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21481,917,809 - 81,922,056 (-)NCBI
NHGRI_mPanPan11380,512,191 - 80,516,052 (-)NCBI
RefSeq Acc Id: XM_057299602   ⟹   XP_057155585
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21481,917,809 - 81,921,684 (-)NCBI
NHGRI_mPanPan11380,512,191 - 80,516,053 (-)NCBI
RefSeq Acc Id: XM_057299603   ⟹   XP_057155586
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21481,917,809 - 81,922,056 (-)NCBI
NHGRI_mPanPan11380,512,191 - 80,516,228 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003825303 (Get FASTA)   NCBI Sequence Viewer  
  XP_057155584 (Get FASTA)   NCBI Sequence Viewer  
  XP_057155585 (Get FASTA)   NCBI Sequence Viewer  
  XP_057155586 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000024539.1
RefSeq Acc Id: XP_003825303   ⟸   XM_003825255
- UniProtKB: A0A2R9BBI5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000024539   ⟸   ENSPPAT00000047364
RefSeq Acc Id: XP_057155586   ⟸   XM_057299603
- UniProtKB: A0A2R9BBI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_057155585   ⟸   XM_057299602
- UniProtKB: A0A2R9BBI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_057155584   ⟸   XM_057299601
- UniProtKB: A0A2R9BBI5 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035406 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000047364.1 UniProtKB/TrEMBL
InterPro Sprouty UniProtKB/TrEMBL
  Sprouty_domain UniProtKB/TrEMBL
NCBI Gene SPRY2 ENTREZGENE
PANTHER PTHR12365:SF8 UniProtKB/TrEMBL
  SPROUTY UniProtKB/TrEMBL
Pfam Sprouty UniProtKB/TrEMBL
PROSITE SPR UniProtKB/TrEMBL
UniProt A0A2R9BBI5 ENTREZGENE, UniProtKB/TrEMBL