Spry2 (sprouty RTK signaling antagonist 2) - Rat Genome Database

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Gene: Spry2 (sprouty RTK signaling antagonist 2) Chinchilla lanigera
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Symbol: Spry2
Name: sprouty RTK signaling antagonist 2
RGD ID: 8750985
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); protein serine/threonine kinase activator activity (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); bud elongation involved in lung branching (ortholog); cell fate commitment (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; ASSOCIATED WITH chromosome 13q14 deletion syndrome (ortholog); cleft lip (ortholog); cleft palate (ortholog); FOUND IN actin cytoskeleton (ortholog); cytoskeleton (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: sprouty homolog 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540427,349,519 - 27,353,706 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540427,349,286 - 27,353,706 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching morphogenesis of an epithelial tube  (ISO)
bud elongation involved in lung branching  (ISO)
cell fate commitment  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
establishment of mitotic spindle orientation  (ISO)
inner ear morphogenesis  (ISO)
lung development  (ISO)
lung growth  (ISO)
lung morphogenesis  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell projection organization  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of lens fiber cell differentiation  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of Ras protein signal transduction  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of vascular endothelial growth factor signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
respiratory system development  (ISO)
sensory perception of sound  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Spry2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540427,349,519 - 27,353,706 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540427,349,286 - 27,353,706 (+)NCBIChiLan1.0ChiLan1.0
SPRY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1380,335,976 - 80,341,126 (-)EnsemblGRCh38hg38GRCh38
GRCh381380,335,976 - 80,341,126 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371380,910,111 - 80,915,261 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361379,808,112 - 79,813,087 (-)NCBINCBI36hg18NCBI36
Build 341379,808,114 - 79,813,087NCBI
Celera1361,811,860 - 61,816,835 (-)NCBI
Cytogenetic Map13q31.1NCBI
HuRef1361,613,784 - 61,618,759 (-)NCBIHuRef
CHM1_11380,877,733 - 80,882,708 (-)NCBICHM1_1
Spry2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914106,129,381 - 106,134,899 (-)NCBIGRCm39mm39
GRCm39 Ensembl14106,129,381 - 106,134,253 (-)Ensembl
GRCm3814105,891,947 - 105,896,819 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14105,891,947 - 105,896,819 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714106,291,164 - 106,296,036 (-)NCBIGRCm37mm9NCBIm37
MGSCv3614104,778,114 - 104,782,418 (-)NCBImm8
Celera14104,512,649 - 104,517,512 (-)NCBICelera
Cytogenetic Map14E2.3NCBI
cM Map1456.16NCBI
Spry2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21582,692,312 - 82,697,408 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1590,172,975 - 90,175,802 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01590,172,769 - 90,177,823 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01593,662,768 - 93,667,781 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41590,009,109 - 90,011,940 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11590,024,884 - 90,027,720 (-)NCBI
Celera1581,798,483 - 81,801,309 (-)NCBICelera
Cytogenetic Map15q22NCBI
SPRY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11380,595,679 - 80,600,670 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1380,596,346 - 80,597,408 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01361,569,658 - 61,574,817 (-)NCBIMhudiblu_PPA_v0panPan3
SPRY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12233,366,139 - 33,371,102 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2233,366,931 - 33,367,878 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2233,168,781 - 33,173,903 (-)NCBI
ROS_Cfam_1.02233,695,480 - 33,700,592 (-)NCBI
UMICH_Zoey_3.12233,352,773 - 33,357,889 (-)NCBI
UNSW_CanFamBas_1.02233,390,454 - 33,395,571 (-)NCBI
UU_Cfam_GSD_1.02233,464,090 - 33,469,216 (-)NCBI
Spry2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945126,035,217 - 126,040,822 (+)NCBI
SpeTri2.0NW_0049365111,452,421 - 1,458,031 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPRY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1152,153,704 - 52,160,497 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11152,153,695 - 52,158,766 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21156,943,755 - 56,948,261 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPRY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1359,357,611 - 59,362,705 (-)NCBI
ChlSab1.1 Ensembl359,358,394 - 59,359,341 (-)Ensembl
Vero_WHO_p1.0NW_02366604615,625,484 - 15,630,748 (-)NCBI
Spry2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475120,091,612 - 20,096,581 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000002742   ⟹   ENSCLAP00000002687
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540427,349,519 - 27,353,706 (+)Ensembl
RefSeq Acc Id: XM_005374123   ⟹   XP_005374180
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540427,349,286 - 27,353,706 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005374180 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005374180   ⟸   XM_005374123
- Sequence:
RefSeq Acc Id: ENSCLAP00000002687   ⟸   ENSCLAT00000002742


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001939 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000002687 ENTREZGENE
Ensembl Transcript ENSCLAT00000002742 ENTREZGENE
NCBI Gene Spry2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Spry2  sprouty RTK signaling antagonist 2    sprouty homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED