Atp1b4 (ATPase Na+/K+ transporting family member beta 4) - Rat Genome Database

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Gene: Atp1b4 (ATPase Na+/K+ transporting family member beta 4) Rattus norvegicus
Analyze
Symbol: Atp1b4
Name: ATPase Na+/K+ transporting family member beta 4
RGD ID: 620994
Description: Predicted to be involved in regulation of DNA-templated transcription. Located in chromatin. Orthologous to human ATP1B4 (ATPase Na+/K+ transporting family member beta 4); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ac2-628; ATPase, (Na+)/K+ transporting, beta 4 polypeptide; x,K-ATPase subunit beta-m; x/potassium-transporting ATPase subunit beta-m
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X117,087,284 - 117,108,023 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX117,057,423 - 117,108,020 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX119,186,440 - 119,207,156 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X122,755,585 - 122,776,301 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X120,301,410 - 120,322,134 (+)NCBIRnor_WKY
Rnor_6.0X124,631,544 - 124,652,520 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX124,631,881 - 124,652,975 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X124,717,191 - 124,738,098 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X7,025,531 - 7,046,207 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X7,031,086 - 7,051,763 (-)NCBI
CeleraX116,305,018 - 116,325,839 (+)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
protein binding  (IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
aldosterone signaling pathway  (IEA)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Identification of a novel gene of the X,K-ATPase beta-subunit family that is predominantly expressed in skeletal and heart muscles. Pestov NB, etal., FEBS Lett 1999 Aug 6;456(2):243-8.
6. Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals. Pestov NB, etal., Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11215-20. Epub 2007 Jun 25.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14656723  


Genomics

Comparative Map Data
Atp1b4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X117,087,284 - 117,108,023 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX117,057,423 - 117,108,020 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX119,186,440 - 119,207,156 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X122,755,585 - 122,776,301 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X120,301,410 - 120,322,134 (+)NCBIRnor_WKY
Rnor_6.0X124,631,544 - 124,652,520 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX124,631,881 - 124,652,975 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X124,717,191 - 124,738,098 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X7,025,531 - 7,046,207 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X7,031,086 - 7,051,763 (-)NCBI
CeleraX116,305,018 - 116,325,839 (+)NCBICelera
Cytogenetic MapXq35NCBI
ATP1B4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X120,362,089 - 120,383,237 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX120,362,085 - 120,383,249 (+)EnsemblGRCh38hg38GRCh38
GRCh37X119,495,944 - 119,517,092 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X119,379,995 - 119,400,254 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X119,277,848 - 119,298,104NCBI
CeleraX119,961,554 - 119,982,718 (+)NCBICelera
Cytogenetic MapXq24NCBI
HuRefX108,947,429 - 108,968,212 (+)NCBIHuRef
CHM1_1X119,407,371 - 119,428,792 (+)NCBICHM1_1
T2T-CHM13v2.0X118,737,159 - 118,758,401 (+)NCBIT2T-CHM13v2.0
Atp1b4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X37,404,999 - 37,425,661 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX37,405,061 - 37,425,646 (+)EnsemblGRCm39 Ensembl
GRCm38X38,316,122 - 38,336,784 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX38,316,184 - 38,336,769 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X35,669,444 - 35,689,890 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X34,560,894 - 34,581,340 (+)NCBIMGSCv36mm8
CeleraX25,962,988 - 25,983,444 (+)NCBICelera
Cytogenetic MapXA3.3NCBI
Atp1b4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555721,507,290 - 1,524,422 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555721,507,290 - 1,524,359 (-)NCBIChiLan1.0ChiLan1.0
ATP1B4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X119,820,695 - 119,841,598 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX119,820,695 - 119,841,598 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X109,633,770 - 109,654,662 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ATP1B4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X92,347,443 - 92,368,206 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX92,347,684 - 92,365,341 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX78,379,094 - 78,399,754 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X94,088,087 - 94,108,743 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX94,088,217 - 94,105,868 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X91,543,107 - 91,563,771 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X93,299,931 - 93,320,587 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X93,081,031 - 93,101,689 (+)NCBIUU_Cfam_GSD_1.0
Atp1b4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X91,263,951 - 91,338,728 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364799,648,315 - 9,666,782 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1B4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX98,514,305 - 98,535,149 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X98,514,286 - 98,535,154 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X112,773,772 - 112,794,615 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP1B4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606533,077,794 - 33,098,919 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp1b4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624931234,103 - 255,189 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624931234,184 - 255,154 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
5685004Bss104Bone structure and strength QTL 1043.9tibia area (VT:1000281)tibia area measurement (CMO:0001382)X113805422126975220Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:692
Count of miRNA genes:309
Interacting mature miRNAs:417
Transcripts:ENSRNOT00000009329
Prediction methods:Miranda, Pita, Pita,Targetscan, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 3 3 3
Low 2 34 26 10 18 10 5 8 9 14 18 11 5
Below cutoff 11 11 11 9 17 17

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009329   ⟹   ENSRNOP00000009329
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX117,087,338 - 117,108,020 (+)Ensembl
Rnor_6.0 EnsemblX124,631,881 - 124,652,975 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105036   ⟹   ENSRNOP00000093493
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX117,057,423 - 117,094,444 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115644   ⟹   ENSRNOP00000087079
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX117,090,002 - 117,108,020 (+)Ensembl
RefSeq Acc Id: NM_053381   ⟹   NP_445833
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X117,087,338 - 117,108,020 (+)NCBI
Rnor_6.0X124,631,846 - 124,652,520 (+)NCBI
Rnor_5.0X124,717,191 - 124,738,098 (+)NCBI
RGSC_v3.4X7,025,531 - 7,046,207 (-)RGD
CeleraX116,305,018 - 116,325,839 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257493   ⟹   XP_006257555
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X117,087,284 - 117,108,023 (+)NCBI
Rnor_6.0X124,631,544 - 124,651,734 (+)NCBI
Rnor_5.0X124,717,191 - 124,738,098 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257494   ⟹   XP_006257556
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X117,087,338 - 117,108,023 (+)NCBI
Rnor_6.0X124,632,814 - 124,651,734 (+)NCBI
Rnor_5.0X124,717,191 - 124,738,098 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257495   ⟹   XP_006257557
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X117,087,338 - 117,108,023 (+)NCBI
Rnor_6.0X124,632,814 - 124,651,734 (+)NCBI
Rnor_5.0X124,717,191 - 124,738,098 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039100113   ⟹   XP_038956041
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X117,087,343 - 117,108,023 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_445833   ⟸   NM_053381
- Sequence:
RefSeq Acc Id: XP_006257555   ⟸   XM_006257493
- Peptide Label: isoform X1
- UniProtKB: G3V6V5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257556   ⟸   XM_006257494
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006257557   ⟸   XM_006257495
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000009329   ⟸   ENSRNOT00000009329
RefSeq Acc Id: XP_038956041   ⟸   XM_039100113
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000093493   ⟸   ENSRNOT00000105036
RefSeq Acc Id: ENSRNOP00000087079   ⟸   ENSRNOT00000115644

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R193-F1-model_v2 AlphaFold Q9R193 1-356 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
X 124636221 124636222 C T snv ACI/N (MCW), F344/NRrrc (MCW), MR/N (MCW), WKY/N (MCW), WN/N (MCW)
X 124640820 124640821 C G snv BXH2/CubMcwi (2020)
X 124648545 124648546 T C snv ACI/N (MCW), F344/NRrrc (MCW), MR/N (MCW), WKY/N (MCW), WN/N (MCW)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
X 117096313 117096314 C G snv BXH2/CubMcwi (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620994 AgrOrtholog
BioCyc Gene G2FUF-1260 BioCyc
Ensembl Genes ENSRNOG00000007059 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009329 ENTREZGENE
  ENSRNOP00000009329.6 UniProtKB/TrEMBL
  ENSRNOP00000087079 ENTREZGENE
  ENSRNOP00000087079.1 UniProtKB/TrEMBL
  ENSRNOP00000093493.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009329 ENTREZGENE
  ENSRNOT00000009329.6 UniProtKB/TrEMBL
  ENSRNOT00000105036.1 UniProtKB/TrEMBL
  ENSRNOT00000115644 ENTREZGENE
  ENSRNOT00000115644.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Na/K_ATPase_sub_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/K_ATPase_sub_beta_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84396 UniProtKB/Swiss-Prot
NCBI Gene 84396 ENTREZGENE
PANTHER PTHR11523 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Na_K-ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp1b4 PhenoGen
PROSITE ATPASE_NA_K_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPASE_NA_K_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs Na_K_ATPase_bet UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A2K8_RAT UniProtKB/TrEMBL
  AT1B4_RAT UniProtKB/Swiss-Prot
  G3V6V5 ENTREZGENE, UniProtKB/TrEMBL
  Q7TPI3_RAT UniProtKB/TrEMBL
  Q9R193 ENTREZGENE
UniProt Secondary Q9R192 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp1b4  ATPase Na+/K+ transporting family member beta 4  Atp1b4  ATPase, (Na+)/K+ transporting, beta 4 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Atp1b4  ATPase, (Na+)/K+ transporting, beta 4 polypeptide      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Atp1b4  ATPase, (Na+)/K+ transporting, beta 4 polypeptide      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in skeletal muscle and heart 631939
gene_protein sequence contains 356 amino acids 631939