RGD Reference Report - Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals. - Rat Genome Database

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Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals.

Authors: Pestov, NB  Ahmad, N  Korneenko, TV  Zhao, H  Radkov, R  Schaer, D  Roy, S  Bibert, S  Geering, K  Modyanov, NN 
Citation: Pestov NB, etal., Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11215-20. Epub 2007 Jun 25.
RGD ID: 2306466
Pubmed: PMID:17592128   (View Abstract at PubMed)
PMCID: PMC2040879   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.0704809104   (Journal Full-text)

Change in gene functions (gene cooption) is one of the key mechanisms of molecular evolution. Genes can acquire new functions via alteration in properties of encoded proteins and/or via changes in temporal or spatial regulation of expression. Here we demonstrate radical changes in the functions of orthologous ATP1B4 genes during evolution of vertebrates. Expression of ATP1B4 genes is brain-specific in teleost fishes, whereas it is predominantly muscle-specific in tetrapods. The encoded beta m-proteins in fish, amphibian, and avian species are beta-subunits of Na,K-ATPase located in the plasma membrane. In placental mammals beta m-proteins lost their ancestral functions, accumulate in nuclear membrane of perinatal myocytes, and associate with transcriptional coregulator Ski-interacting protein (SKIP). Through interaction with SKIP, eutherian beta m acquired new functions as exemplified by regulation of TGF-beta-responsive reporters and by augmentation of mRNA levels of Smad7, an inhibitor of TGF-beta signaling. Thus, orthologous vertebrate ATP1B4 genes represent an instance of gene cooption that created fundamental changes in the functional properties of the encoded proteins.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chromatin  IDA 2306466; 2306466 RGD 
SMAD protein complex  IDA 2306466 RGD 

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Atp1b4  (ATPase Na+/K+ transporting family member beta 4)
Snw1  (SNW domain containing 1)
Tor1aip1  (torsin 1A interacting protein 1)


Additional Information