Rdx (radixin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Rdx (radixin) Rattus norvegicus
Analyze
Symbol: Rdx
Name: radixin
RGD ID: 1359472
Description: Enables actin binding activity and protein kinase A binding activity. Involved in several processes, including apical protein localization; barbed-end actin filament capping; and cellular response to platelet-derived growth factor stimulus. Located in several cellular components, including T-tubule; cleavage furrow; and midbody. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24. Orthologous to human RDX (radixin); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC95168; radixin isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8861,275,792 - 61,348,260 (+)NCBIGRCr8
mRatBN7.2852,379,494 - 52,437,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl852,379,494 - 52,437,678 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx857,928,308 - 57,971,180 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0856,207,282 - 56,250,158 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0854,071,527 - 54,114,400 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0856,570,728 - 56,612,851 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl856,585,396 - 56,610,612 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0855,152,377 - 55,194,097 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4855,404,000 - 55,450,183 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1855,423,053 - 55,469,236 (+)NCBI
Celera851,903,656 - 51,946,436 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
diuron  (EXP)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (ISO)
hydrazine  (ISO)
hypochlorous acid  (ISO)
isoflavones  (ISO)
ivermectin  (ISO)
lycopene  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
microcystin-LR  (EXP)
naphthalene  (ISO)
nitric oxide  (EXP)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
tanespimycin  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
uranium atom  (ISO)
vinclozolin  (EXP)
Y-27632  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
adherens junction  (IBA,IDA)
apical part of cell  (IBA,IEA,ISO)
apical plasma membrane  (IEA,ISO)
cell periphery  (IEA,ISO)
cell projection  (IEA)
cell tip  (IDA)
cleavage furrow  (IDA)
cortical actin cytoskeleton  (IDA,IEA,ISO)
cytoskeleton  (IEA)
filopodium  (IBA,IDA,IEA,ISO)
focal adhesion  (IEA,ISO)
lamellipodium  (IDA,IEA,ISO)
membrane  (IEA)
microvillus  (IBA,IDA,IEA,ISO)
midbody  (IDA)
plasma membrane  (IBA,IDA,IEA,ISO)
ruffle  (IEA,ISO)
stereocilium  (IEA,ISO)
stereocilium base  (IEA,ISO)
T-tubule  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Ezrin has properties to self-associate at the plasma membrane. Andréoli C, etal., J Cell Sci. 1994 Sep;107 ( Pt 9):2509-21. doi: 10.1242/jcs.107.9.2509.
2. ERM proteins mediate the effects of Na+/H+ exchanger (NHE1) activation in cardiac myocytes. Darmellah A, etal., Cardiovasc Res. 2009 Feb 1;81(2):294-300. doi: 10.1093/cvr/cvn320. Epub 2008 Nov 21.
3. Radixin is a novel member of the band 4.1 family. Funayama N, etal., J Cell Biol 1991 Nov;115(4):1039-48.
4. Asymmetric ERM activation at the Schwann cell process tip is required in axon-associated motility. Gatto CL, etal., J Cell Physiol. 2007 Jan;210(1):122-32.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. Griffon N, etal., Brain Res Mol Brain Res 2003 Sep 10;117(1):47-57.
7. Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferation. Hochbaum D, etal., J Biol Chem. 2011 Jan 7;286(1):859-66. doi: 10.1074/jbc.M110.163816. Epub 2010 Nov 3.
8. The cytoskeletal linking proteins, moesin and radixin, are upregulated by platelet-derived growth factor, but not basic fibroblast growth factor in experimental mesangial proliferative glomerulonephritis. Hugo C, et al., J Clin Invest. 1996 Jun 1;97(11):2499-508.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. ERMs colocalize transiently with L1 during neocortical axon outgrowth. Mintz CD, etal., J Comp Neurol 2003 Sep 29;464(4):438-48.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Retrieval of the rat canalicular conjugate export pump Mrp2 is associated with a rearrangement of actin filaments and radixin in bile salt-induced cholestasis. Rost D, etal., Eur J Med Res. 2008 Jul 28;13(7):314-8.
16. Radixin, a barbed end-capping actin-modulating protein, is concentrated at the cleavage furrow during cytokinesis. Sato N, et al., J Cell Biol. 1991 Apr;113(2):321-30.
17. Ezrin, radixin, and moesin are components of Schwann cell microvilli. Scherer SS, etal., J Neurosci Res. 2001 Jul 15;65(2):150-64.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: purification and characterization. Tsukita S, et al., J Cell Biol. 1989 Jun;108(6):2369-82.
20. Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytes. Wang W, etal., Gastroenterology. 2006 Sep;131(3):878-84.
Additional References at PubMed
PMID:9472040   PMID:9563848   PMID:9890997   PMID:12068294   PMID:15093731   PMID:16502470   PMID:16582480   PMID:17021174   PMID:17634366   PMID:17825285   PMID:19056867   PMID:19199708  
PMID:19783662   PMID:20458337   PMID:20868650   PMID:21148287   PMID:21282464   PMID:21423176   PMID:22132106   PMID:22291017   PMID:22467863   PMID:22658674   PMID:23264465   PMID:23533145  
PMID:24184478   PMID:25468996   PMID:25854562   PMID:31654296  


Genomics

Comparative Map Data
Rdx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8861,275,792 - 61,348,260 (+)NCBIGRCr8
mRatBN7.2852,379,494 - 52,437,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl852,379,494 - 52,437,678 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx857,928,308 - 57,971,180 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0856,207,282 - 56,250,158 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0854,071,527 - 54,114,400 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0856,570,728 - 56,612,851 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl856,585,396 - 56,610,612 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0855,152,377 - 55,194,097 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4855,404,000 - 55,450,183 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1855,423,053 - 55,469,236 (+)NCBI
Celera851,903,656 - 51,946,436 (+)NCBICelera
Cytogenetic Map8q24NCBI
RDX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811110,174,922 - 110,296,614 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11109,864,295 - 110,296,712 (-)EnsemblGRCh38hg38GRCh38
GRCh3711110,045,647 - 110,167,339 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611109,605,376 - 109,672,647 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411109,605,381 - 109,655,644NCBI
Celera11107,253,634 - 107,320,905 (-)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11105,970,010 - 106,091,683 (-)NCBIHuRef
CHM1_111109,928,800 - 110,050,624 (-)NCBICHM1_1
T2T-CHM13v2.011110,184,743 - 110,306,806 (-)NCBIT2T-CHM13v2.0
Rdx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39951,958,450 - 52,000,038 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl951,958,473 - 52,011,763 (+)EnsemblGRCm39 Ensembl
GRCm38952,047,150 - 52,088,738 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl952,047,173 - 52,100,463 (+)EnsemblGRCm38mm10GRCm38
MGSCv37951,855,255 - 51,896,843 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36951,800,692 - 51,841,101 (+)NCBIMGSCv36mm8
Celera949,323,161 - 49,364,735 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map928.62NCBI
Rdx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541212,100,359 - 12,172,545 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541212,100,436 - 12,184,444 (-)NCBIChiLan1.0ChiLan1.0
RDX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29110,909,905 - 111,019,235 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111112,003,902 - 112,130,151 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011105,075,716 - 105,176,660 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111108,921,477 - 109,005,557 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11108,921,477 - 109,005,557 (-)Ensemblpanpan1.1panPan2
RDX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1522,555,913 - 22,642,822 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl522,571,286 - 22,642,811 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha522,474,394 - 22,561,935 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0522,581,249 - 22,668,985 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl522,581,164 - 22,668,972 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1522,639,826 - 22,727,131 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0522,539,744 - 22,627,628 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0522,589,215 - 22,677,042 (+)NCBIUU_Cfam_GSD_1.0
Rdx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494792,645,011 - 92,713,067 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366123,992,542 - 4,040,315 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366123,992,542 - 4,060,598 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RDX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl938,220,447 - 38,322,097 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1938,243,608 - 38,299,561 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2942,953,206 - 43,009,694 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RDX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11101,554,640 - 101,647,765 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1101,554,334 - 101,623,093 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604324,300,763 - 24,397,097 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rdx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247845,221,045 - 5,271,045 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247845,198,433 - 5,304,953 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rdx
251 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:372
Count of miRNA genes:216
Interacting mature miRNAs:256
Transcripts:ENSRNOT00000034924
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat

Markers in Region
RH143457  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2852,420,390 - 52,420,605 (+)MAPPERmRatBN7.2
Rnor_6.0856,610,992 - 56,611,206NCBIRnor6.0
Rnor_5.0855,192,238 - 55,192,452UniSTSRnor5.0
RGSC_v3.4855,448,323 - 55,448,537UniSTSRGSC3.4
Celera851,944,577 - 51,944,791UniSTS
RH 3.4 Map8567.4UniSTS
Cytogenetic Map8q24UniSTS
AA965233  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2852,421,694 - 52,421,786 (+)MAPPERmRatBN7.2
Rnor_6.0856,612,296 - 56,612,387NCBIRnor6.0
Rnor_5.0855,193,542 - 55,193,633UniSTSRnor5.0
RGSC_v3.4855,449,628 - 55,449,719UniSTSRGSC3.4
Celera851,945,881 - 51,945,972UniSTS
RH 3.4 Map8567.4UniSTS
Cytogenetic Map8q24UniSTS
EST5F4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8861,298,738 - 61,299,619 (+)Marker Load Pipeline
Celera851,926,477 - 51,927,357UniSTS
Cytogenetic Map8q24UniSTS
RH124276  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0856,593,580 - 56,594,936NCBIRnor6.0
Rnor_5.0855,174,276 - 55,175,746UniSTSRnor5.0
Celera851,925,834 - 51,927,351UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001005889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005487816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010053960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010053961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010053962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY428868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF307742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000034924   ⟹   ENSRNOP00000035840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl852,379,494 - 52,437,678 (+)Ensembl
Rnor_6.0 Ensembl856,585,396 - 56,610,612 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085316   ⟹   ENSRNOP00000071354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl852,396,870 - 52,422,249 (+)Ensembl
Rnor_6.0 Ensembl856,585,396 - 56,598,818 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097554   ⟹   ENSRNOP00000081059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl852,396,903 - 52,422,249 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099146   ⟹   ENSRNOP00000088386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl852,396,870 - 52,422,249 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117679   ⟹   ENSRNOP00000077207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl852,379,494 - 52,422,249 (+)Ensembl
RefSeq Acc Id: NM_001005889   ⟹   NP_001005889
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,275,792 - 61,318,545 (+)NCBI
mRatBN7.2852,379,494 - 52,422,250 (+)NCBI
Rnor_6.0856,570,728 - 56,612,851 (+)NCBI
Rnor_5.0855,152,377 - 55,194,097 (+)NCBI
RGSC_v3.4855,404,000 - 55,450,183 (+)RGD
Celera851,903,656 - 51,946,436 (+)RGD
Sequence:
RefSeq Acc Id: XM_039081452   ⟹   XP_038937380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,276,128 - 61,333,968 (+)NCBI
mRatBN7.2852,379,833 - 52,434,891 (+)NCBI
RefSeq Acc Id: XM_039081453   ⟹   XP_038937381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,275,806 - 61,333,968 (+)NCBI
mRatBN7.2852,379,510 - 52,437,673 (+)NCBI
RefSeq Acc Id: XM_039081455   ⟹   XP_038937383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,275,806 - 61,331,713 (+)NCBI
mRatBN7.2852,379,510 - 52,435,418 (+)NCBI
RefSeq Acc Id: XM_039081456   ⟹   XP_038937384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,275,806 - 61,304,648 (+)NCBI
mRatBN7.2852,394,135 - 52,408,351 (+)NCBI
RefSeq Acc Id: XM_063265453   ⟹   XP_063121523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,275,806 - 61,348,260 (+)NCBI
RefSeq Acc Id: XM_063265454   ⟹   XP_063121524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,276,127 - 61,331,713 (+)NCBI
RefSeq Acc Id: XM_063265455   ⟹   XP_063121525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,275,806 - 61,331,713 (+)NCBI
RefSeq Acc Id: XM_063265456   ⟹   XP_063121526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,275,806 - 61,331,713 (+)NCBI
RefSeq Acc Id: XM_063265459   ⟹   XP_063121529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,276,123 - 61,304,648 (+)NCBI
RefSeq Acc Id: XR_005487816
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,275,806 - 61,333,968 (+)NCBI
mRatBN7.2852,379,510 - 52,437,673 (+)NCBI
RefSeq Acc Id: XR_010053960
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,275,806 - 61,333,968 (+)NCBI
RefSeq Acc Id: XR_010053961
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,275,806 - 61,331,713 (+)NCBI
RefSeq Acc Id: XR_010053962
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,275,806 - 61,333,968 (+)NCBI
RefSeq Acc Id: NP_001005889   ⟸   NM_001005889
- UniProtKB: Q5PQK5 (UniProtKB/TrEMBL),   A0A8I5Y0V6 (UniProtKB/TrEMBL),   Q5WQV5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071354   ⟸   ENSRNOT00000085316
Ensembl Acc Id: ENSRNOP00000035840   ⟸   ENSRNOT00000034924
RefSeq Acc Id: XP_038937381   ⟸   XM_039081453
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038937383   ⟸   XM_039081455
- Peptide Label: isoform X2
- UniProtKB: Q5WQV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937380   ⟸   XM_039081452
- Peptide Label: isoform X1
- UniProtKB: E9PT65 (UniProtKB/TrEMBL),   Q5WQV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937384   ⟸   XM_039081456
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000088386   ⟸   ENSRNOT00000099146
Ensembl Acc Id: ENSRNOP00000077207   ⟸   ENSRNOT00000117679
Ensembl Acc Id: ENSRNOP00000081059   ⟸   ENSRNOT00000097554
RefSeq Acc Id: XP_063121523   ⟸   XM_063265453
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063121525   ⟸   XM_063265455
- Peptide Label: isoform X2
- UniProtKB: Q5WQV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121526   ⟸   XM_063265456
- Peptide Label: isoform X2
- UniProtKB: Q5WQV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121529   ⟸   XM_063265459
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063121524   ⟸   XM_063265454
- Peptide Label: isoform X1
Protein Domains
FERM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PT65-F1-model_v2 AlphaFold E9PT65 1-583 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695965
Promoter ID:EPDNEW_R6490
Type:single initiation site
Name:Rdx_1
Description:radixin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0856,585,334 - 56,585,394EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359472 AgrOrtholog
BioCyc Gene G2FUF-30487 BioCyc
Ensembl Genes ENSRNOG00000012237 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034924 ENTREZGENE
  ENSRNOT00000034924.6 UniProtKB/TrEMBL
  ENSRNOT00000085316 ENTREZGENE
  ENSRNOT00000085316.2 UniProtKB/TrEMBL
  ENSRNOT00000097554.1 UniProtKB/TrEMBL
  ENSRNOT00000099146.1 UniProtKB/TrEMBL
  ENSRNOT00000117679 ENTREZGENE
  ENSRNOT00000117679.1 UniProtKB/TrEMBL
  ENSRNOT00000157352 ENTREZGENE
Gene3D-CATH 1.20.5.450 UniProtKB/TrEMBL
  1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  6.10.360.10 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130553 IMAGE-MGC_LOAD
InterPro Band_41_domain UniProtKB/TrEMBL
  ERM UniProtKB/TrEMBL
  ERM_C_dom UniProtKB/TrEMBL
  ERM_FERM_C UniProtKB/TrEMBL
  ERM_helical UniProtKB/TrEMBL
  Ez/rad/moesin UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_3-hlx UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/TrEMBL
  Moesin UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:315655 UniProtKB/TrEMBL
MGC_CLONE MGC:95168 IMAGE-MGC_LOAD
NCBI Gene 315655 ENTREZGENE
PANTHER PTHR23281 UniProtKB/TrEMBL
Pfam ERM_C UniProtKB/TrEMBL
  ERM_helical UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
PharmGKB RDX RGD
PhenoGen Rdx PhenoGen
PIRSF ERM UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/TrEMBL
  ERMFAMILY UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012237 RatGTEx
SMART B41 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
Superfamily-SCOP FERM_3-hlx UniProtKB/TrEMBL
  Moesin UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A0G2K095_RAT UniProtKB/TrEMBL
  A0A8I5Y0V6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZR70_RAT UniProtKB/TrEMBL
  A0A8I6AIS5_RAT UniProtKB/TrEMBL
  E9PT65 ENTREZGENE, UniProtKB/TrEMBL
  Q5PQK5 ENTREZGENE, UniProtKB/TrEMBL
  Q5WQV5 ENTREZGENE, UniProtKB/TrEMBL
  T1SRT4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Rdx  radixin      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Rdx  radixin      Symbol and Name status set to provisional 70820 PROVISIONAL