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Gene: Ift172 (intraflagellar transport 172) Rattus norvegicus

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Symbol:

Ift172 (Ensembl: AABR07063281.1)

Name:

intraflagellar transport 172

RGD ID:

620744

Description:

Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in sperm cytoplasmic droplet; sperm midpiece; and sperm principal piece. Predicted to be part of intraciliary transport particle B. Predicted to be active in axoneme and ciliary basal body. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 20; retinitis pigmentosa 71; and short-rib thoracic dysplasia 10 with or without polydactyly. Orthologous to human IFT172 (intraflagellar transport 172); PARTICIPATES IN Hedgehog signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

intraflagellar transport 172 homolog; intraflagellar transport 172 homolog (Chlamydomonas); intraflagellar transport protein 172 homolog; selective LIM binding factor homolog; selective LIM binding factor, rat homolog; selective LIM-binding factor; Slb

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	IFT172 (intraflagellar transport 172)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Ift172 (intraflagellar transport 172)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ift172 (intraflagellar transport 172)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	IFT172 (intraflagellar transport 172)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	IFT172 (intraflagellar transport 172)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ift172 (intraflagellar transport 172)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	IFT172 (intraflagellar transport 172)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	IFT172 (intraflagellar transport 172)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ift172 (intraflagellar transport 172)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ZFP91 (ZFP91 zinc finger protein, atypical E3 ubiquitin ligase)	HGNC	OMA
Homo sapiens (human):	ZFP91-CNTF (ZFP91-CNTF readthrough (NMD candidate))	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	IFT172 (intraflagellar transport 172)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ift172 (intraflagellar transport 172)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ift172 (intraflagellar transport 172)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Oseg2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	osm-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ift172	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	30,801,841 - 30,841,239 (+)	NCBI		GRCr8
mRatBN7.2	6	25,081,933 - 25,121,271 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	25,081,980 - 25,120,860 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	25,382,814 - 25,422,109 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	25,698,704 - 25,738,001 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	25,178,064 - 25,217,359 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	26,390,686 - 26,485,459 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	6	36,210,777 - 36,304,662 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	6	24,573,352 - 24,613,367 (+)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift172	Rat	asphyxiating thoracic dystrophy 1		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Short-rib thoracic dysplasia 1 with or without polydactyly	ClinVar	PMID:25741868\|PMID:28492532
Ift172	Rat	Bardet-Biedl syndrome		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Bardet-Biedl syndrome	ClinVar	PMID:24033266\|PMID:24140113\|PMID:25168386\|PMID:25741868\|PMID:28492532
Ift172	Rat	Bardet-Biedl syndrome 1		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Bardet-Biedl syndrome 1	ClinVar	PMID:25741868\|PMID:28492532
Ift172	Rat	Bardet-Biedl syndrome 20		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Bardet-Biedl syndrome 20	ClinVar	PMID:11030072\|PMID:16199547\|PMID:17576681\|PMID:24033266\|PMID:24140113\|PMID:24290075\|PMID:25168386\|PMID:25664603\|PMID:25741868\|PMID:26763875\|PMID:28492532\|PMID:28559085\|PMID:29068549\|PMID:31054281\|PMID:31475041\|PMID:31587445\|PMID:32451492\|PMID:32939031\|PMID:34906470\|PMID:35982159\|PMID:36307859\|PMID:36413997\|PMID:9536098
Ift172	Rat	Bardet-Biedl syndrome 22		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Bardet-Biedl syndrome 22	ClinVar	PMID:24290075\|PMID:25741868\|PMID:28492532\|PMID:31587445\|PMID:32451492
Ift172	Rat	fundus dystrophy		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Retinal dystrophy	ClinVar	PMID:17576681\|PMID:24140113\|PMID:25741868\|PMID:26893459\|PMID:28492532\|PMID:28559085\|PMID:32451492\|PMID:35982159\|PMID:9536098
Ift172	Rat	genetic disease		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:24140113\|PMID:25741868\|PMID:28492532\|PMID:31475041\|PMID:34906470\|PMID:36413997
Ift172	Rat	Joubert syndrome 1		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Familial aplasia of the vermis	ClinVar	PMID:24140113\|PMID:25741868\|PMID:26092869\|PMID:28492532
Ift172	Rat	nephronophthisis		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Nephronophthisis	ClinVar	PMID:25741868
Ift172	Rat	Neurodevelopmental Disorders		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868\|PMID:28492532
Ift172	Rat	optic atrophy		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Optic atrophy	ClinVar	PMID:25741868\|PMID:28492532\|PMID:35835773
Ift172	Rat	retinitis pigmentosa		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Retinitis pigmentosa	ClinVar	PMID:11030072\|PMID:24140113\|PMID:25664603\|PMID:25741868\|PMID:28492532\|PMID:34906470
Ift172	Rat	retinitis pigmentosa 71		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Retinitis pigmentosa 71	ClinVar	PMID:11030072\|PMID:16199547\|PMID:17576681\|PMID:24033266\|PMID:24140113\|PMID:25168386\|PMID:25664603\|PMID:25741868\|PMID:28492532\|PMID:28559085\|PMID:29068549\|PMID:31054281\|PMID:31475041\|PMID:32451492\|PMID:32783370\|PMID:32939031\|PMID:34906470\|PMID:35835773\|PMID:35982159\|PMID:36307859\|PMID:36413997\|PMID:9536098
Ift172	Rat	short-rib thoracic dysplasia 10 with or without polydactyly		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Short-rib thoracic dysplasia 10 with or without polydactyly \| ClinVar more ...	ClinVar	PMID:11030072\|PMID:16199547\|PMID:17576681\|PMID:24033266\|PMID:24140113\|PMID:24290075\|PMID:25168386\|PMID:25640679\|PMID:25664603\|PMID:25741868\|PMID:26092869\|PMID:26893459\|PMID:28492532\|PMID:28559085\|PMID:29068549\|PMID:31054281\|PMID:31475041\|PMID:31587445\|PMID:31964843\|PMID:32451492\|PMID:32783370\|PMID:32939031\|PMID:33393400\|PMID:34906470\|PMID:35562395\|PMID:35835773\|PMID:35982159\|PMID:36307859\|PMID:36413997\|PMID:37217489\|PMID:9536098
Ift172	Rat	short-rib thoracic dysplasia 6 with or without polydactyly		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Short-rib thoracic dysplasia 6 with or without polydactyly	ClinVar	PMID:24140113\|PMID:25741868\|PMID:28492532\|PMID:29068549
Ift172	Rat	syndromic microphthalmia 5		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Anophthalmia-microphthalmia syndrome	ClinVar	PMID:26893459\|PMID:28492532
Ift172	Rat	Tatton-Brown-Rahman syndrome		ISO	RGD:731569	8554872	ClinVar Annotator: match by term: Tatton-Brown-Rahman overgrowth syndrome	ClinVar	PMID:28492532

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift172	Rat	asphyxiating thoracic dystrophy		ISO	RGD:731569	11554173	CTD Direct Evidence: marker/mechanism	CTD
Ift172	Rat	gastrointestinal stromal tumor		ISO	RGD:731569	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:27793025

Imported Disease Annotations - MGI

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift172	Rat	atrioventricular septal defect		ISS	RGD:1552058	13592920	OMIM:600309 \| OMIM:606215 \| OMIM:606217 \| OMIM:614430 \| OMIM:614474	MouseDO
Ift172	Rat	retinal degeneration		ISS	RGD:1552058	13592920		MouseDO
Ift172	Rat	VACTERL association		ISS	RGD:1552058	13592920	OMIM:192350 \| OMIM:276950	MouseDO

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift172	Rat	Bardet-Biedl syndrome 20		ISO	RGD:731569	7240710		OMIM
Ift172	Rat	retinitis pigmentosa 71		ISO	RGD:731569	7240710		OMIM
Ift172	Rat	short-rib thoracic dysplasia 10 with or without polydactyly		ISO	RGD:731569	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift172	Rat	1,2-dimethylhydrazine	increases expression	ISO	RGD:1552058	6480464	1,2-Dimethylhydrazine results in increased expression of IFT172 mRNA	CTD	PMID:22206623
Ift172	Rat	17alpha-ethynylestradiol	increases expression	ISO	RGD:1552058	6480464	Ethinyl Estradiol results in increased expression of IFT172 mRNA	CTD	PMID:17942748
Ift172	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1552058	6480464	Tetrachlorodibenzodioxin affects the expression of IFT172 mRNA	CTD	PMID:21570461
Ift172	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:1552058	6480464	Tetrachlorodibenzodioxin results in decreased expression of IFT172 mRNA	CTD	PMID:26290441
Ift172	Rat	2,4-dinitrotoluene	affects expression	EXP		6480464	2,4-dinitrotoluene affects the expression of SLB mRNA	CTD	PMID:21346803
Ift172	Rat	2,6-dinitrotoluene	affects expression	EXP		6480464	2,6-dinitrotoluene affects the expression of SLB mRNA	CTD	PMID:21346803
Ift172	Rat	4,4'-sulfonyldiphenol	decreases methylation	ISO	RGD:731569	6480464	bisphenol S results in decreased methylation of IFT172 gene	CTD	PMID:31601247
Ift172	Rat	acetamide	increases expression	EXP		6480464	acetamide results in increased expression of IFT172 mRNA	CTD	PMID:31881176
Ift172	Rat	aflatoxin B1	increases methylation	ISO	RGD:731569	6480464	Aflatoxin B1 results in increased methylation of IFT172 polyA tail	CTD	PMID:30157460
Ift172	Rat	all-trans-retinoic acid	multiple interactions	ISO	RGD:731569	6480464	[Tretinoin co-treated with arsenic trioxide] results in decreased expression of IFT172 mRNA	CTD	PMID:15894607
Ift172	Rat	all-trans-retinoic acid	decreases expression	ISO	RGD:731569	6480464	Tretinoin results in decreased expression of IFT172 mRNA	CTD	PMID:33167477
Ift172	Rat	aristolochic acid A	decreases expression	ISO	RGD:731569	6480464	aristolochic acid I results in decreased expression of IFT172 mRNA	CTD	PMID:33212167
Ift172	Rat	arsane	multiple interactions	ISO	RGD:731569	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Ift172	Rat	arsenic atom	multiple interactions	ISO	RGD:731569	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Ift172	Rat	arsenite(3-)	multiple interactions	ISO	RGD:731569	6480464	arsenite inhibits the reaction [G3BP1 protein binds to IFT172 mRNA]	CTD	PMID:32406909
Ift172	Rat	arsenous acid	multiple interactions	ISO	RGD:731569	6480464	[Tretinoin co-treated with Arsenic Trioxide] results in decreased expression of IFT172 mRNA	CTD	PMID:15894607
Ift172	Rat	atrazine	decreases expression	ISO	RGD:731569	6480464	Atrazine results in decreased expression of IFT172 mRNA	CTD	PMID:22378314
Ift172	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:731569	6480464	Benzo(a)pyrene results in decreased expression of IFT172 mRNA	CTD	PMID:26238291
Ift172	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:731569	6480464	Benzo(a)pyrene affects the methylation of IFT172 promoter	CTD	PMID:27901495
Ift172	Rat	beta-lapachone	decreases expression	ISO	RGD:731569	6480464	beta-lapachone results in decreased expression of IFT172 mRNA	CTD	PMID:38218311
Ift172	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	RGD:1552058	6480464	Diethylhexyl Phthalate results in increased expression of IFT172 mRNA	CTD	PMID:34319233
Ift172	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of IFT172 mRNA	CTD	PMID:25181051
Ift172	Rat	bisphenol A	increases methylation	ISO	RGD:731569	6480464	bisphenol A results in increased methylation of IFT172 gene	CTD	PMID:31601247
Ift172	Rat	bisphenol A	increases expression	ISO	RGD:731569	6480464	bisphenol A results in increased expression of IFT172 mRNA	CTD	PMID:33670352
Ift172	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of IFT172 mRNA	CTD	PMID:30816183
Ift172	Rat	cadmium atom	multiple interactions	ISO	RGD:1552058	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IFT172 more ...	CTD	PMID:37325564
Ift172	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1552058	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IFT172 more ...	CTD	PMID:37325564
Ift172	Rat	carbon nanotube	decreases expression	ISO	RGD:1552058	6480464	Nanotubes, Carbon results in decreased expression of IFT172 mRNA	CTD	PMID:25620056
Ift172	Rat	cisplatin	decreases expression	ISO	RGD:731569	6480464	Cisplatin results in decreased expression of IFT172 mRNA	CTD	PMID:27594783
Ift172	Rat	cisplatin	decreases expression	ISO	RGD:1552058	6480464	Cisplatin results in decreased expression of IFT172 mRNA	CTD	PMID:24865317
Ift172	Rat	cisplatin	multiple interactions	ISO	RGD:1552058	6480464	[Cisplatin co-treated with Lutein] results in decreased expression of IFT172 mRNA	CTD	PMID:24865317
Ift172	Rat	clofibrate	decreases expression	EXP		6480464	Clofibrate results in decreased expression of IFT172 mRNA	CTD	PMID:12851107
Ift172	Rat	diarsenic trioxide	multiple interactions	ISO	RGD:731569	6480464	[Tretinoin co-treated with Arsenic Trioxide] results in decreased expression of IFT172 mRNA	CTD	PMID:15894607
Ift172	Rat	dicrotophos	increases expression	ISO	RGD:731569	6480464	dicrotophos results in increased expression of IFT172 mRNA	CTD	PMID:28302478
Ift172	Rat	doxorubicin	increases expression	ISO	RGD:731569	6480464	Doxorubicin results in increased expression of IFT172 mRNA	CTD	PMID:29803840
Ift172	Rat	enzalutamide	affects expression	ISO	RGD:731569	6480464	enzalutamide affects the expression of IFT172 mRNA	CTD	PMID:30940724
Ift172	Rat	epoxiconazole	decreases expression	ISO	RGD:1552058	6480464	epoxiconazole results in decreased expression of IFT172 mRNA	CTD	PMID:35436446
Ift172	Rat	ethanol	affects expression	ISO	RGD:1552058	6480464	Ethanol affects the expression of IFT172 mRNA	CTD	PMID:30319688
Ift172	Rat	folic acid	decreases expression	ISO	RGD:1552058	6480464	Folic Acid results in decreased expression of IFT172 mRNA	CTD	PMID:25629700
Ift172	Rat	glycidyl methacrylate	decreases expression	ISO	RGD:731569	6480464	glycidyl methacrylate results in decreased expression of IFT172 protein	CTD	PMID:36641056
Ift172	Rat	iron atom	increases expression	EXP		6480464	Iron deficiency results in increased expression of SLB mRNA	CTD	PMID:16629162
Ift172	Rat	iron(0)	increases expression	EXP		6480464	Iron deficiency results in increased expression of SLB mRNA	CTD	PMID:16629162
Ift172	Rat	lead diacetate	increases expression	ISO	RGD:1552058	6480464	lead acetate results in increased expression of IFT172 mRNA	CTD	PMID:29746905
Ift172	Rat	lutein	multiple interactions	ISO	RGD:1552058	6480464	[Cisplatin co-treated with Lutein] results in decreased expression of IFT172 mRNA	CTD	PMID:24865317
Ift172	Rat	lutein	decreases expression	ISO	RGD:1552058	6480464	Lutein results in decreased expression of IFT172 mRNA	CTD	PMID:24865317
Ift172	Rat	manganese atom	multiple interactions	ISO	RGD:731569	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Ift172	Rat	manganese(0)	multiple interactions	ISO	RGD:731569	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Ift172	Rat	manganese(II) chloride	multiple interactions	ISO	RGD:731569	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Ift172	Rat	methylmercury chloride	decreases expression	ISO	RGD:731569	6480464	methylmercuric chloride results in decreased expression of IFT172 mRNA	CTD	PMID:28001369
Ift172	Rat	N,N-diethyl-m-toluamide	multiple interactions	EXP		6480464	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of IFT172 mRNA	CTD	PMID:28659758
Ift172	Rat	N-ethyl-N-nitrosourea	increases mutagenesis	ISO	RGD:1552058	6480464	Ethylnitrosourea results in increased mutagenesis of IFT172 gene	CTD	PMID:15755804
Ift172	Rat	nickel atom	decreases expression	ISO	RGD:731569	6480464	Nickel results in decreased expression of IFT172 mRNA	CTD	PMID:25583101
Ift172	Rat	permethrin	multiple interactions	EXP		6480464	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of IFT172 mRNA	CTD	PMID:28659758
Ift172	Rat	pirinixic acid	decreases expression	ISO	RGD:1552058	6480464	pirinixic acid results in decreased expression of IFT172 mRNA	CTD	PMID:17426115
Ift172	Rat	Pyridostigmine bromide	multiple interactions	EXP		6480464	[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of IFT172 mRNA	CTD	PMID:28659758
Ift172	Rat	quercetin	decreases expression	ISO	RGD:731569	6480464	Quercetin results in decreased expression of IFT172 mRNA	CTD	PMID:21632981
Ift172	Rat	silver atom	decreases expression	ISO	RGD:1552058	6480464	Silver results in decreased expression of IFT172 mRNA	CTD	PMID:19429238
Ift172	Rat	silver atom	increases expression	ISO	RGD:1552058	6480464	Silver results in increased expression of IFT172 mRNA	CTD	PMID:27131904
Ift172	Rat	silver(0)	decreases expression	ISO	RGD:1552058	6480464	Silver results in decreased expression of IFT172 mRNA	CTD	PMID:19429238
Ift172	Rat	silver(0)	increases expression	ISO	RGD:1552058	6480464	Silver results in increased expression of IFT172 mRNA	CTD	PMID:27131904
Ift172	Rat	sodium arsenite	decreases expression	ISO	RGD:731569	6480464	sodium arsenite results in decreased expression of IFT172 mRNA	CTD	PMID:38568856
Ift172	Rat	sodium arsenite	multiple interactions	ISO	RGD:731569	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Ift172	Rat	tetrachloromethane	decreases expression	EXP		6480464	Carbon Tetrachloride results in decreased expression of IFT172 mRNA	CTD	PMID:31150632
Ift172	Rat	titanium dioxide	decreases expression	ISO	RGD:1552058	6480464	titanium dioxide results in decreased expression of IFT172 mRNA	CTD	PMID:23557971
Ift172	Rat	trovafloxacin	decreases expression	ISO	RGD:1552058	6480464	trovafloxacin results in decreased expression of IFT172 mRNA	CTD	PMID:35537566

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift172	Rat	bone development	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	bone development	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:4821824 PMID:21653639	RGD	PMID:21653639
Ift172	Rat	brain development	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	brain development	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:3829198 PMID:18930042	RGD	PMID:18930042
Ift172	Rat	cilium assembly	involved_in	ISO	RGD:1552058	1624291	PMID:14603322	RGD	PMID:14603322
Ift172	Rat	cilium assembly	involved_in	IEA	UniProtKB:Q9UG01\|ensembl:ENSP00000260570	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	cilium assembly	involved_in	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	cilium assembly	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:2682066\|MGI:4821824 PMID:18488998, PMID:21552265, PMID:21653639, PMID:28778798	RGD	PMID:18488998\|PMID:21552265\|PMID:21653639\|PMID:28778798
Ift172	Rat	cilium assembly	involved_in	ISS	UniProtKB:Q6VH22	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Ift172	Rat	cilium assembly	involved_in	ISO	RGD:731569	1624291	PMID:24140113	RGD	PMID:24140113
Ift172	Rat	cilium assembly	involved_in	ISS	UniProtKB:Q9UG01	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Ift172	Rat	cytoplasmic microtubule organization	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	cytoplasmic microtubule organization	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	PMID:21703454	RGD	PMID:21703454
Ift172	Rat	determination of left/right symmetry	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	determination of left/right symmetry	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:2682066 PMID:15755804	RGD	PMID:15755804
Ift172	Rat	dorsal/ventral pattern formation	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	dorsal/ventral pattern formation	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:108075\|MGI:2682066 PMID:14603322, PMID:15755804, PMID:16061793, PMID:21552265	RGD	PMID:14603322\|PMID:15755804\|PMID:16061793\|PMID:21552265
Ift172	Rat	embryonic camera-type eye morphogenesis	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	embryonic camera-type eye morphogenesis	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:2682066 PMID:28778798	RGD	PMID:28778798
Ift172	Rat	epidermis development	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	PMID:21703454	RGD	PMID:21703454
Ift172	Rat	epidermis development	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	heart development	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:4821824 PMID:21653639	RGD	PMID:21653639
Ift172	Rat	heart development	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	heart looping	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:3829198 PMID:18930042	RGD	PMID:18930042
Ift172	Rat	heart looping	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	hindgut development	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	hindgut development	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:4821824 PMID:21653639	RGD	PMID:21653639
Ift172	Rat	intraciliary transport	involved_in	IBA	FB:FBgn0035317\|FB:FBgn0260933\|MGI:2146906\|PANTHER:PTN000404360\|UniProtKB:Q57ZX9\|UniProtKB:Q96RY7	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ift172	Rat	keratinocyte proliferation	acts_upstream_of	ISO	RGD:1552058	1624291	PMID:21703454	RGD	PMID:21703454
Ift172	Rat	keratinocyte proliferation	acts_upstream_of	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	left/right axis specification	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:2682066\|MGI:3829198 PMID:18930042, PMID:22554696	RGD	PMID:18930042\|PMID:22554696
Ift172	Rat	left/right axis specification	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	limb development	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:2450929\|MGI:3829198\|MGI:4420980\|MGI:4821824 PMID:18930042, PMID:19521792, PMID:21653639	RGD	PMID:18930042\|PMID:19521792\|PMID:21653639
Ift172	Rat	limb development	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	negative regulation of epithelial cell proliferation	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	PMID:21703454	RGD	PMID:21703454
Ift172	Rat	negative regulation of epithelial cell proliferation	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	negative regulation of keratinocyte proliferation	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	PMID:21703454	RGD	PMID:21703454
Ift172	Rat	negative regulation of keratinocyte proliferation	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	negative regulation of smoothened signaling pathway	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:2682066 PMID:28778798	RGD	PMID:28778798
Ift172	Rat	negative regulation of smoothened signaling pathway	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	negative regulation of transcription by RNA polymerase II		IMP		633929		RGD
Ift172	Rat	neural tube closure	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:3829198 PMID:18930042	RGD	PMID:18930042
Ift172	Rat	neural tube closure	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	neural tube development	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:2176180\|MGI:4420980 PMID:19521792	RGD	PMID:19521792
Ift172	Rat	neural tube development	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	neural tube formation	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:2682066 PMID:14603322	RGD	PMID:14603322
Ift172	Rat	neural tube formation	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	non-motile cilium assembly	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:3829198 PMID:18930042, PMID:21703454	RGD	PMID:18930042\|PMID:21703454
Ift172	Rat	non-motile cilium assembly	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	Notch signaling pathway	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	PMID:21703454	RGD	PMID:21703454
Ift172	Rat	Notch signaling pathway	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	positive regulation of smoothened signaling pathway	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	positive regulation of smoothened signaling pathway	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:2682066 PMID:18488998	RGD	PMID:18488998
Ift172	Rat	protein processing	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:2682066 PMID:16061793	RGD	PMID:16061793
Ift172	Rat	protein processing	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	regulation of smoothened signaling pathway	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	regulation of smoothened signaling pathway	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:4821824 PMID:21653639	RGD	PMID:21653639
Ift172	Rat	roof of mouth development	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:4821824 PMID:21653639	RGD	PMID:21653639
Ift172	Rat	roof of mouth development	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	smoothened signaling pathway	involved_in	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	smoothened signaling pathway	involved_in	ISO	RGD:1552058	1624291	PMID:11062270	RGD	PMID:11062270
Ift172	Rat	spinal cord motor neuron differentiation	acts_upstream_of_or_within	ISO	RGD:1552058	1624291	MGI:2682066 PMID:21552265	RGD	PMID:21552265
Ift172	Rat	spinal cord motor neuron differentiation	acts_upstream_of_or_within	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift172	Rat	axoneme	is_active_in	IBA	MGI:2146906\|PANTHER:PTN000404360\|UniProtKB:A0A644F0T7\|UniProtKB:A8BAF1\|UniProtKB:A8BJ87	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ift172	Rat	cell projection	located_in	IEA	UniProtKB-KW:KW-0966	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ift172	Rat	ciliary basal body	is_active_in	IBA	MGI:2146906\|PANTHER:PTN000404360\|UniProtKB:A0A644F0T7\|UniProtKB:A8BAF1\|UniProtKB:A8BJ87\|UniProtKB:Q96RY7	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ift172	Rat	cilium	located_in	IEA	UniProtKB-SubCell:SL-0066	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Ift172	Rat	cilium	located_in	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	cilium	located_in	ISS	UniProtKB:Q6VH22	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Ift172	Rat	cilium	located_in	IEA	UniProtKB-KW:KW-0969	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ift172	Rat	cilium	located_in	ISO	RGD:1552058	1624291	PMID:14603322	RGD	PMID:14603322
Ift172	Rat	intraciliary transport particle B	part_of	ISS	UniProtKB:Q6VH22	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Ift172	Rat	intraciliary transport particle B	part_of	ISO	RGD:1552058	1624291	PMID:23055941, PMID:24596149, PMID:25443296	RGD	PMID:23055941\|PMID:24596149\|PMID:25443296
Ift172	Rat	intraciliary transport particle B	part_of	IEA	UniProtKB:Q9UG01\|ensembl:ENSP00000260570	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	intraciliary transport particle B	part_of	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	intraciliary transport particle B	part_of	IBA	MGI:2682064\|PANTHER:PTN000404408\|UniProtKB:Q9UG01\|WB:WBGene00003883	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ift172	Rat	intraciliary transport particle B	part_of	ISO	RGD:731569	1624291	PMID:26980730	RGD	PMID:26980730
Ift172	Rat	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Ift172	Rat	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ift172	Rat	sperm cytoplasmic droplet	located_in	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	sperm cytoplasmic droplet	located_in	ISO	RGD:1552058	1624291	PMID:24339785	RGD	PMID:24339785
Ift172	Rat	sperm midpiece	located_in	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	sperm midpiece	located_in	ISO	RGD:1552058	1624291	PMID:23055941, PMID:24339785	RGD	PMID:23055941\|PMID:24339785
Ift172	Rat	sperm principal piece	located_in	IEA	UniProtKB:Q6VH22\|ensembl:ENSMUSP00000049335	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift172	Rat	sperm principal piece	located_in	ISO	RGD:1552058	1624291	PMID:23055941	RGD	PMID:23055941

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift172	Rat	protein binding	enables	ISO	RGD:1552058	1624291	PR:E9Q9D5\|PR:P10126\|UniProtKB:Q61371 PMID:11062270, PMID:21689717, PMID:23055941	RGD	PMID:11062270\|PMID:21689717\|PMID:23055941
Ift172	Rat	transcription factor binding		IDA		633929	Lhx2, Lhx3, Lhx4, Lmx-1	RGD

Molecular Pathway Annotations Click to see Annotation Detail View

Imported Annotations - PID (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift172	Rat	Hedgehog signaling pathway		ISO	RGD:731569	6484113		PID	PID:200172

Disease Annotations Click to see Annotation Detail View

asphyxiating thoracic dystrophy (ISO)

asphyxiating thoracic dystrophy 1 (ISO)

atrioventricular septal defect (ISS)

Bardet-Biedl syndrome (ISO)

Bardet-Biedl syndrome 1 (ISO)

Bardet-Biedl syndrome 20 (ISO)

Bardet-Biedl syndrome 22 (ISO)

fundus dystrophy (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

Joubert syndrome 1 (ISO)

nephronophthisis (ISO)

Neurodevelopmental Disorders (ISO)

optic atrophy (ISO)

retinal degeneration (ISS)

retinitis pigmentosa (ISO)

retinitis pigmentosa 71 (ISO)

short-rib thoracic dysplasia 10 with or without polydactyly (ISO)

short-rib thoracic dysplasia 6 with or without polydactyly (ISO)

syndromic microphthalmia 5 (ISO)

Tatton-Brown-Rahman syndrome (ISO)

VACTERL association (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

clofibrate (EXP)

diarsenic trioxide (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

enzalutamide (ISO)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

glycidyl methacrylate (ISO)

iron atom (EXP)

iron(0) (EXP)

lead diacetate (ISO)

lutein (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methylmercury chloride (ISO)

N,N-diethyl-m-toluamide (EXP)

N-ethyl-N-nitrosourea (ISO)

nickel atom (ISO)

permethrin (EXP)

pirinixic acid (ISO)

Pyridostigmine bromide (EXP)

quercetin (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

trovafloxacin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone development (IEA,ISO)

brain development (IEA,ISO)

cilium assembly (IEA,ISO,ISS)

cytoplasmic microtubule organization (IEA,ISO)

determination of left/right symmetry (IEA,ISO)

dorsal/ventral pattern formation (IEA,ISO)

embryonic camera-type eye morphogenesis (IEA,ISO)

epidermis development (IEA,ISO)

heart development (IEA,ISO)

heart looping (IEA,ISO)

hindgut development (IEA,ISO)

intraciliary transport (IBA)

keratinocyte proliferation (IEA,ISO)

left/right axis specification (IEA,ISO)

limb development (IEA,ISO)

negative regulation of epithelial cell proliferation (IEA,ISO)

negative regulation of keratinocyte proliferation (IEA,ISO)

negative regulation of smoothened signaling pathway (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IMP)

neural tube closure (IEA,ISO)

neural tube development (IEA,ISO)

neural tube formation (IEA,ISO)

non-motile cilium assembly (IEA,ISO)

Notch signaling pathway (IEA,ISO)

positive regulation of smoothened signaling pathway (IEA,ISO)

protein processing (IEA,ISO)

regulation of smoothened signaling pathway (IEA,ISO)

roof of mouth development (IEA,ISO)

smoothened signaling pathway (IEA,ISO)

spinal cord motor neuron differentiation (IEA,ISO)

Cellular Component

axoneme (IBA)

cell projection (IEA)

ciliary basal body (IBA)

cilium (IEA,ISO,ISS)

intraciliary transport particle B (IBA,IEA,ISO,ISS)

nucleus (IEA)

sperm cytoplasmic droplet (IEA,ISO)

sperm midpiece (IEA,ISO)

sperm principal piece (IEA,ISO)

Molecular Function

protein binding (ISO)

transcription factor binding (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

Hedgehog signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors.	Howard PW and Maurer RA, J Biol Chem 2000 May 5;275(18):13336-42.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11062270	PMID:14603322	PMID:15755804	PMID:16061793	PMID:18488998	PMID:18930042	PMID:19521792	PMID:21552265	PMID:21653639	PMID:21703454	PMID:22554696	PMID:23055941
PMID:24140113	PMID:24339785	PMID:24596149	PMID:24769233	PMID:25443296	PMID:28778798

Genomics

Comparative Map Data

Ift172
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	30,801,841 - 30,841,239 (+)	NCBI		GRCr8
mRatBN7.2	6	25,081,933 - 25,121,271 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	25,081,980 - 25,120,860 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	25,382,814 - 25,422,109 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	25,698,704 - 25,738,001 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	25,178,064 - 25,217,359 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	26,390,686 - 26,485,459 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	6	36,210,777 - 36,304,662 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	6	24,573,352 - 24,613,367 (+)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

IFT172
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	27,444,377 - 27,489,743 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	27,444,377 - 27,489,805 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	27,667,244 - 27,712,610 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	27,520,744 - 27,566,075 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	27,578,891 - 27,624,222	NCBI
Celera	2	27,513,414 - 27,558,746 (-)	NCBI		Celera
Cytogenetic Map	2	p23.3	NCBI
HuRef	2	27,409,128 - 27,454,460 (-)	NCBI		HuRef
CHM1_1	2	27,597,152 - 27,642,482 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	27,486,730 - 27,532,099 (-)	NCBI		T2T-CHM13v2.0

Ift172
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	31,410,623 - 31,448,458 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	31,410,621 - 31,448,460 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	31,253,279 - 31,291,391 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	31,253,277 - 31,291,116 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	31,555,652 - 31,593,487 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	31,529,860 - 31,567,695 (-)	NCBI		MGSCv36	mm8
Celera	5	28,732,431 - 28,770,403 (-)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	17.27	NCBI

Ift172
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	9,418,609 - 9,455,026 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	9,418,599 - 9,455,026 (-)	NCBI	ChiLan1.0	ChiLan1.0

IFT172
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	99,022,173 - 99,066,368 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	99,026,177 - 99,070,336 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	27,448,139 - 27,492,302 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	27,536,534 - 27,580,406 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	27,536,534 - 27,580,406 (-)	Ensembl	panpan1.1		panPan2

IFT172
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	21,389,462 - 21,426,970 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	21,389,482 - 21,426,796 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	21,281,228 - 21,318,724 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	21,710,828 - 21,748,327 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	21,710,832 - 21,748,293 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	21,397,430 - 21,434,930 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	21,406,908 - 21,444,410 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	21,455,165 - 21,492,664 (-)	NCBI		UU_Cfam_GSD_1.0

Ift172
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	65,694,405 - 65,731,092 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	5,108,437 - 5,145,160 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	5,108,437 - 5,145,160 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IFT172
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	111,683,669 - 111,718,970 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	111,683,674 - 111,718,504 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	118,754,392 - 118,789,234 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IFT172
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	80,130,436 - 80,171,259 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666045	31,982,836 - 32,026,287 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ift172
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	9,510,512 - 9,545,933 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	9,510,452 - 9,546,985 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ift172
85 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	69
Count of miRNA genes:	64
Interacting mature miRNAs:	69
Transcripts:	ENSRNOT00000074263
Prediction methods:	Microtar, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	41223769	Rat
1549905	Stresp10	Stress response QTL 10	6.83	0.0066	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	6	1	27574569	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	1	34235784	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	16536140	61536140	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	41223769	Rat
1578758	Tcas9	Tongue tumor susceptibility QTL 9	3.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	6	1	37618905	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	41223769	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	39036266	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	43394190	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	41223769	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	41223769	Rat
738023	Alc17	Alcohol consumption QTL 17	3.1	0.003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	6	1	27574569	Rat
1354616	Despr12	Despair related QTL 12		0.0012	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	6	1	27574569	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	42487980	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	42487980	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42838846	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
2300176	Bmd51	Bone mineral density QTL 51	11.7	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	6	1	27574569	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	34434305	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	20338777	62613667	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	42487980	Rat
1359023	Bp272	Blood pressure QTL 272	2.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	16536140	27261739	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	16536140	71636405	Rat
2300190	Bmd52	Bone mineral density QTL 52	11.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	6	1	27574569	Rat

Markers in Region

RH92034

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	6	30,840,509 - 30,840,772 (+)	Marker Load Pipeline
mRatBN7.2	6	25,120,541 - 25,120,804 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	26,484,730 - 26,484,992	NCBI	Rnor6.0
Rnor_5.0	6	36,303,933 - 36,304,195	UniSTS	Rnor5.0
Celera	6	24,612,638 - 24,612,900	UniSTS

RH131827

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	6	30,840,938 - 30,841,223 (+)	Marker Load Pipeline
mRatBN7.2	6	25,120,970 - 25,121,255 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	26,485,159 - 26,485,443	NCBI	Rnor6.0
Rnor_5.0	6	36,304,362 - 36,304,646	UniSTS	Rnor5.0
Celera	6	24,613,067 - 24,613,351	UniSTS

RH143087

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	25,084,133 - 25,084,250 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	26,392,846 - 26,392,962	NCBI	Rnor6.0
Rnor_5.0	6	36,212,937 - 36,213,053	UniSTS	Rnor5.0
Celera	6	24,575,512 - 24,575,628	UniSTS
RH 3.4 Map	6	120.5	UniSTS

RH134643

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	6	30,840,239 - 30,840,731 (+)	Marker Load Pipeline
mRatBN7.2	6	25,120,271 - 25,120,763 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	26,484,460 - 26,484,951	NCBI	Rnor6.0
Rnor_5.0	6	36,303,663 - 36,304,154	UniSTS	Rnor5.0
Celera	6	24,612,368 - 24,612,859	UniSTS
RH 3.4 Map	6	91.0	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001434132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_053792	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF226993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000085424 ⟹ ENSRNOP00000072658

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	25,081,980 - 25,120,860 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090342 ⟹ ENSRNOP00000070902

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	25,081,980 - 25,120,860 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000091528 ⟹ ENSRNOP00000069468

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	25,081,980 - 25,120,860 (+)	Ensembl

RefSeq Acc Id:

NM_053792 ⟹ NP_446244

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	30,801,944 - 30,841,239 (+)	NCBI
mRatBN7.2	6	25,081,974 - 25,121,271 (+)	NCBI
Rnor_6.0	6	26,390,686 - 26,485,459 (+)	NCBI
Rnor_5.0	6	36,210,777 - 36,304,662 (+)	NCBI
Celera	6	24,573,352 - 24,613,367 (+)	RGD

Sequence:

show sequence

CAGGGTGCCGGATGCTTGGGCGGGGTTGTTCCAGGTAACCGTGGGGAGTTGTCTCGGTCAAGCG
AGCATCCGAGACCGGTGTGGCGTCATGCAGTTGAAGCACCTGAGGACCCTGCTGAGCCCTCAGG
ATGGAGCTGCGAAGGTGACCTGCATGGCCTGGTCCCAGAACAATGCTAAATTTGCTGTCTGCAC
AGTGGACCGAGTGGTACTGCTGTACGATGAACACGGGGAGCGGAGAGACAAGTTCTCCACCAAA
CCAGCTGACATGAAGTATGGCAGGAAGAGCTACATGGTCAAAGGCATGGCTTTCTCTCCTGATT
CCACAAAAATTGCCATAGGACAGACTGACAACATCATCTATGTCTACAAGATAGGAGAAGACTG
GGGTGACAAGAAGGTCATCTGCAACAAGTTCATCCAGACGAGTGCCGTCACTTGTCTGCAGTGG
CCTGCGGAGTATATCATTGTCTTTGGACTGGCTGAAGGCAAGGTTCGCTTAGCAAACACAAAAA
CTAACAAGTCATCTACTATCTATGGGACAGATTCCTACGTGGTAGCGCTGACAACCAACTGCTC
TGGGAAAGGGATTCTCTCGGGTCACGCGGACGGCACCATCGTTAGGTATTTCTTCGATGACGAA
GGCTCGGGAGAGTCACAGGGGAAGTTGGTTAACCATCCATGCCCACCCTATGCCTTGGCCTGGG
CCACCAACAGCATTGTGGCTGCTGGCTGTGATCGGAGGATTGTGGCCTATGGAAAGGAAGGCCA
TGTGCTACAGACTTTCGACTATAGCCGTGACCCTCAGGAGCGGGAGTTCACCACAGCTGCTGCA
AGTCCTGGAGGCCAGTCTGTTGTTCTTGGAAGTTATGACAGACTTCGGGTGTTCAACTGGAGTC
CTCGAAGAAGCATCTGGGAAGAGGCAAAGCCCAAGGAGATTGCCAACTTATACACAGTCACCGC
CTTGGCCTGGAAGCGGGATGGCTCTCGGCTCTGTGCGGGAACACTCTGTGGTGGGGTGGAACAG
TTTGACTGCTGCCTCCGAAGGAGCATTTACAAGAACAAGTTCGAGCTGACATATGTGGGCCCTA
GCCAGCTGATTGTGAAGAACCTGTCTTCGGGGACCAGGGTGGTGCTCAAGTCACACTATGGCTA
CGAAGTGGAAGAGGTGAAAATCCTGGGAAAGGAACGTTACCTGGTGGCTCACACTTCAGACACG
CTGCTGCTGGGAGACCTCAACACAAACCGCCTCAGTGAGATACCCTGGCAGGGATCGGGTGGCA
ATGAGAAATATTTCTTTGAAAATGAGAATGTCTGCATGATCTTCAATGCTGGAGAGCTGACCCT
GGTGGAATATGGGAGTAACGACTCCTTGGGTTCTGTGCGCACTGAATTCATGAACCCTCACCTC
ATCAGCGTCCGTATCAATGAGAGGTGCCAGCGAGGAATGGAAGACAATAAGAAATTGGCTTATC
TTGTTGATATTAAGACGATTGCTATAGTGGATCTGATCGGTGGCTACAACATTGGTACTATCAG
TCACGAAAGCCGTGTGGATTGGCTGGAACTTAACGAAACTGGGCACAAGCTTCTCTTCAGAGAC
CGGAAACTTCGTTTGCATCTGTACGATATTGAAAGCTGCTCTAAGACAATGATCCTGAACTTCT
GCTCCTACGTGCAGTGGGTTCCCGGGAGTGATGTGCTGGTGGCTCAGAACCGGAACAGCTTATG
TGTCTGGTACAATATCGAGGCACCTGAGAGAGTCACCATGTCCTCTATCAGGGGTGATGTTGTC
GGTCTGGAGAGAGGTGGTGGGAAGACGGAGGTCATGGTGACAGAAGGTGTGACTACTGTGGCCT
ACACCCTGGATGAGGGCCTGATTGAGTTTGGAACAGCCATCGATGACGGCAACTACACCCGGGC
AACAGCCTTCTTGGAGACCCTGGAGATGACCCCAGAAACAGAGGCAATGTGGAAAACCTTGAGC
AAACTGGCCCTGGAAGCAAGGCAGCTTCACACTGCTGAGAGGTGCTTCTCTGCTTTGGGTCACG
TGGCCAAAGCTCGGTTCCTGCATGAGACCAATGAGATAGCGGATCAGGTGTCCAGGGAATATGG
TGGAGAAGGAACGGACTTCTATCAGGTTCGAGCTCGCCTCGCCATGCTGGAGAAGAACTACAAA
CTGGCCGAAATGATCTTCTTGGAACAGAATGCTGTTGAAGAAGCCATGGACATGTACCAGGAGC
TGCACCGCTGGGATGAATGCATTGCTGTGGCTGAGGCCAAGGGACACCCAGCCCTGGAGAAGCT
ACGCAGAGATTACTATCAGAGATTAATGGACACACAGCAAGAGGAACGAGCAGGTGAACTGCAG
GAGAGTCAAGGGGATGGGCTGGCAGCCATCAGCCTCTACCTCAAAGCTGGGCTCCCTGCCAAAG
CCGCACGGCTGGTGCTGACGCGAGAGGAGCTGCTGGCCAACACGGAGCTGGTAGAACATATCAC
CACAGCCCTCATCAAGGGAGAGCTCTATGAAAGGGCAGGTGATCTCTTTGAGAAGATTCGAAAT
CCACAGCGGGCCCTTGAGTGCTACTGTAAAGGCAACGCATTCATGAAAGCTGTTGAGCTGGCTC
GACTGGCCTTCCCAGTGGAGGTGGTGAGGCTGGAGGAGGCCTGGGGGGACCACTTGGTACAGCA
AAAGCAGCTGGACGCGGCCATCAATCACTATATTGAAGCCAGGTGCTCCATTAAAGCAATTGAG
GCTGCCCTGGGTGCCCGCCAGTGGAAGAAGGCAATTTATATATTAGATCTGCAGGATAGAAACA
CTGCATCTAAATACTATCCTCGTGTGGCCCAACACTATGCATCTCTGCAGGAGTATGAGATCGC
TGAGGAGCTCTACACCAAAGGAGACCGGACCAAAGATGCTATAGACATGTACACCCAGGCTGGT
CGCTGGGAGCAAGCCCACAAGCTGGCCATGAAGTGCATGCGACCAGAAGACGTGTCAGTGCTCT
ACATCACACAGGCCCAGGAAATGGAGAAGCAGGGCAAGTACCGAGAGGCCGAGAGGCTGTACGT
GACAGTGGAGGAGCCTGATCTTGCCATCACCATGTTCAAAAAGCACAAGTTGTATGACGACATG
ATTCGCCTGGTGGGGAAGCACCATCCAGACCTCCTCAGCGACACACACCTTCACCTGGGCAAGG
AGCTGGAGACAGAAGGCCGACTGCAAGAGGCTGAGTACCACTACCTCGAGGCCCAGGAATGGAA
GGCAACTGTGAACATGTACCGGTCCAGCGGGCTTTGGGAGGAGGCCTACCGGGTGGCCAAAGCC
CACGGAGGAGCCAACGCCCACAAACACGTGGCCTATCTGTGGGCGAAGAGCCTGGGAGGAGAGG
CTGCGGTCAGACTGCTCAACAAGCTGGGGCTTCTAGAGGCTGCCATTGACCATGCTGCTGACAA
CTGCTCCTTTGAGTTTGCCTTTGAACTCTCTCGGCTAGCCCTCAAGCACAAAACCCCGGAGATT
CATCTCAGATACGCCATGTACCTGGAAGATGAGGGTAAATTTGAAGAGGCTGAAGCTGAATTCA
TCCGGGCTGGTAAACCCAAGGAGGCAGTCCTCATGTTTGTCCACAACCAGGATTGGGAGGCAGC
TCAGCGTGTGGCTGAGGCCCACGATCCTGACAGTGTTGCTGAGGTACTTGTAGGCCAGGCCCGT
GGGGCCTTGGAGGAGAAGGACTTTCAGAAGGCAGAAGGGTTGCTGCTTCGGGCCCAGAGACCAG
GCCTGGCTCTCAATTATTATAAGGAGGCTGGACTCTGGAGTGATGCTCTGAGGATCTGCAAGGA
CTATGTGCCTGGCCAGCTGGAGGCCCTGCAGGAAGAGTATGAGCGAGAAGCTACCAAGAAGGGG
GGCAGAGGCGTGGAGGGACTTGTAGAACAGGCACGGCAATGGGAACAGGCTGGAGAGTATAGCC
GTGCAGTGGACTGCTACCTCAAAGTTCGAGACTCAGGAAGCAGTGGCCTGATGGAGAAGTGCTG
GATGAAGGCGGCTGAACTGTCCATCAAGTTCCTGCCTCCCCAGCGAAGTCTGGAAGTGGTTCGG
GTTGTAGGTCCCCAGCTGATTGGAATTGGAAAGCACAGTGCTTCTGCAGAACTCTATCTGAACC
TGGACCTTGTCAAAGAAGCAATTGATGCCTTCATTGAGGGTGAAGAGTGGAACAAGGCCAAGCG
CGTGGCCAAAGAGCTAGATCCCCGGTATGAAGACTATGTGGATCAGCATTATAAGGAGTTCCTC
AAGAACCAGGGTAAAGTGGATTCGCTGGTGGGTGTGGACGTAGTAGCTGCCTTGGACCTGTATG
TGGAGCAGGGCCAGTGGGATAAGTGCATTGAAACGGCTACCAAACAGAACTACAAGATTCTGCA
CAAGTATGTGGCTCTGTATGCGACTCATCTGATCCGAGAAGGTGGCTATGCCCAGGCCCTGGCC
CTCTACGTGCAACATGGAGCCCCTGCTAACCCCCAGAATTTCAACATCTACAAAAGGATCTTCA
CTGACATGGTTAGCTCTCCTGGGACCAACAATGCTGAGGCCTACCATAGCTGGGCTGACCTTCG
GGATGTCCTCTTCAACCTGTGTGAAAACCTGGTGAAGTCCAGCGAGGCAAACTCGGCAGCTCAT
GAGGAGTTTGAGATGATGCTGCTGATCGCTCATTACTATGCGACACGATCCGCAGCGCAGAGCA
TCAAACAGCTGGAAACCGTAGCTGCTAGACTTTCCGTTTCGCTCTTGCGCCACACCCAGTTACT
ACCTGCGGACAAGGCCTTTTATGAAGCAGGCACTGCTGCCAAGGAAGTTGGCTGGGAGAACATG
GCCTTCATTTTCTTCAACCGATTTTTGGATCTGACTGATGCCATCGAAGAAGGGACCTTGGATG
CCCTGGACCACTCTGATTTTCAGGACACAGACATTCCCTTTGAGGTGCCACTCCCTGCCAAGCA
GCATGTCCCGGAGGCCCAGAGAGAAGAGGTTCGAGACTGGGTGCTCACAGTCTCGATGGACCAG
AGGCTGGAGCAGGTTCTGCCCCGAGATGAGCGTGGTGTCTACGAGGCTTCCCTAGTGGCAGCGA
GCACTGGAGTCCGGGCCCTGCCCTGTCTCATTACAGGTTACCCCATTCTGAGGAACAAAATTGA
ATTTAAGCGGCCTGGGAAGGCTGCTAACAAAGACAACTGGAACAAGTTTCTTATGGCCATCAAG
ACCTCCCACAGTCCAGTGTGCCAGGATGTGCTCAAATTCATCAGCCAGTGGTGTGGTGGGCTCC
CCAGCACCAGCTTTTCCTTTCAGTGACTGGTGCAACTGAGAAGTTTAGATCTGTTCCTCATTAA
AGTTCTGTGGGAATTC

hide sequence

RefSeq Acc Id:

XM_039111607 ⟹ XP_038967535

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	30,801,841 - 30,840,831 (+)	NCBI
mRatBN7.2	6	25,081,933 - 25,120,863 (+)	NCBI

RefSeq Acc Id:

XM_039111609 ⟹ XP_038967537

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	30,807,575 - 30,840,831 (+)	NCBI
mRatBN7.2	6	25,087,605 - 25,120,863 (+)	NCBI

RefSeq Acc Id:

XM_039111610 ⟹ XP_038967538

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	30,816,418 - 30,840,831 (+)	NCBI
mRatBN7.2	6	25,096,437 - 25,120,863 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001421061	(Get FASTA)	NCBI Sequence Viewer
	NP_446244	(Get FASTA)	NCBI Sequence Viewer
	XP_038967535	(Get FASTA)	NCBI Sequence Viewer
	XP_038967537	(Get FASTA)	NCBI Sequence Viewer
	XP_038967538	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF68274	(Get FASTA)	NCBI Sequence Viewer
	EDM02915	(Get FASTA)	NCBI Sequence Viewer
	EDM02916	(Get FASTA)	NCBI Sequence Viewer
	EDM02917	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069468
GenBank Protein	Q9JKU3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446244 ⟸ NM_053792

- Sequence:

show sequence

MQLKHLRTLLSPQDGAAKVTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGR
KSYMVKGMAFSPDSTKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQWPAEYIIVF
GLAEGKVRLANTKTNKSSTIYGTDSYVVALTTNCSGKGILSGHADGTIVRYFFDDEGSGESQGK
LVNHPCPPYALAWATNSIVAAGCDRRIVAYGKEGHVLQTFDYSRDPQEREFTTAAASPGGQSVV
LGSYDRLRVFNWSPRRSIWEEAKPKEIANLYTVTALAWKRDGSRLCAGTLCGGVEQFDCCLRRS
IYKNKFELTYVGPSQLIVKNLSSGTRVVLKSHYGYEVEEVKILGKERYLVAHTSDTLLLGDLNT
NRLSEIPWQGSGGNEKYFFENENVCMIFNAGELTLVEYGSNDSLGSVRTEFMNPHLISVRINER
CQRGMEDNKKLAYLVDIKTIAIVDLIGGYNIGTISHESRVDWLELNETGHKLLFRDRKLRLHLY
DIESCSKTMILNFCSYVQWVPGSDVLVAQNRNSLCVWYNIEAPERVTMSSIRGDVVGLERGGGK
TEVMVTEGVTTVAYTLDEGLIEFGTAIDDGNYTRATAFLETLEMTPETEAMWKTLSKLALEARQ
LHTAERCFSALGHVAKARFLHETNEIADQVSREYGGEGTDFYQVRARLAMLEKNYKLAEMIFLE
QNAVEEAMDMYQELHRWDECIAVAEAKGHPALEKLRRDYYQRLMDTQQEERAGELQESQGDGLA
AISLYLKAGLPAKAARLVLTREELLANTELVEHITTALIKGELYERAGDLFEKIRNPQRALECY
CKGNAFMKAVELARLAFPVEVVRLEEAWGDHLVQQKQLDAAINHYIEARCSIKAIEAALGARQW
KKAIYILDLQDRNTASKYYPRVAQHYASLQEYEIAEELYTKGDRTKDAIDMYTQAGRWEQAHKL
AMKCMRPEDVSVLYITQAQEMEKQGKYREAERLYVTVEEPDLAITMFKKHKLYDDMIRLVGKHH
PDLLSDTHLHLGKELETEGRLQEAEYHYLEAQEWKATVNMYRSSGLWEEAYRVAKAHGGANAHK
HVAYLWAKSLGGEAAVRLLNKLGLLEAAIDHAADNCSFEFAFELSRLALKHKTPEIHLRYAMYL
EDEGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEKDF
QKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPGQLEALQEEYEREATKKGGRGVEGLV
EQARQWEQAGEYSRAVDCYLKVRDSGSSGLMEKCWMKAAELSIKFLPPQRSLEVVRVVGPQLIG
IGKHSASAELYLNLDLVKEAIDAFIEGEEWNKAKRVAKELDPRYEDYVDQHYKEFLKNQGKVDS
LVGVDVVAALDLYVEQGQWDKCIETATKQNYKILHKYVALYATHLIREGGYAQALALYVQHGAP
ANPQNFNIYKRIFTDMVSSPGTNNAEAYHSWADLRDVLFNLCENLVKSSEANSAAHEEFEMMLL
IAHYYATRSAAQSIKQLETVAARLSVSLLRHTQLLPADKAFYEAGTAAKEVGWENMAFIFFNRF
LDLTDAIEEGTLDALDHSDFQDTDIPFEVPLPAKQHVPEAQREEVRDWVLTVSMDQRLEQVLPR
DERGVYEASLVAASTGVRALPCLITGYPILRNKIEFKRPGKAANKDNWNKFLMAIKTSHSPVCQ
DVLKFISQWCGGLPSTSFSFQ

hide sequence

RefSeq Acc Id:	XP_038967535 ⟸ XM_039111607
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038967537 ⟸ XM_039111609
- Peptide Label:	isoform X2
- UniProtKB:	Q9JKU3 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038967538 ⟸ XM_039111610
- Peptide Label:	isoform X3
- UniProtKB:	A6HA62 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000070902 ⟸ ENSRNOT00000090342

Ensembl Acc Id:

ENSRNOP00000072658 ⟸ ENSRNOT00000085424

Ensembl Acc Id:

ENSRNOP00000069468 ⟸ ENSRNOT00000091528

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JVF8-F1-model_v2	AlphaFold	A0A0G2JVF8	1-495	view protein structure
AF-Q9JKU3-F1-model_v2	AlphaFold	Q9JKU3	1-1749	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620744	AgrOrtholog
BioCyc Gene	G2FUF-38355	BioCyc
Ensembl Genes	ENSRNOG00000057813	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000091528	ENTREZGENE
Gene3D-CATH	1.25.40.470	UniProtKB/Swiss-Prot
	2.130.10.10	UniProtKB/Swiss-Prot
InterPro	ARM-type_fold	UniProtKB/Swiss-Prot
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/Swiss-Prot
	WD40_repeat	UniProtKB/Swiss-Prot
	WD40_repeat_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:116475	UniProtKB/Swiss-Prot
NCBI Gene	116475	ENTREZGENE
PANTHER	IFT140/172-RELATED	UniProtKB/Swiss-Prot
	INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG	UniProtKB/Swiss-Prot
Pfam	WD40	UniProtKB/Swiss-Prot
PhenoGen	Ift172	PhenoGen
RatGTEx	ENSRNOG00000057813	RatGTEx
SMART	WD40	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48371	UniProtKB/Swiss-Prot
	SSF50978	UniProtKB/Swiss-Prot
	Tricorn protease domain 2	UniProtKB/Swiss-Prot
UniProt	A0A096MJL0	ENTREZGENE, UniProtKB/TrEMBL
	A0A096MK45_RAT	UniProtKB/TrEMBL
	A0A0G2JVF8_RAT	UniProtKB/TrEMBL
	A6HA62	ENTREZGENE, UniProtKB/TrEMBL
	IF172_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-07-09	Ift172	intraflagellar transport 172	Ift172	intraflagellar transport 172 homolog (Chlamydomonas)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-25	Ift172	intraflagellar transport 172 homolog (Chlamydomonas)	Slb	selective LIM binding factor, rat homolog	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-08-07	Slb	selective LIM binding factor, rat homolog			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains seven WD40 repeats and a putative nuclear localization signal	633929
gene_expression	highly expressed in testis and pituitary cells	633929

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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