Slc6a18 (solute carrier family 6 member 18) - Rat Genome Database

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Gene: Slc6a18 (solute carrier family 6 member 18) Rattus norvegicus
Analyze
Symbol: Slc6a18
Name: solute carrier family 6 member 18
RGD ID: 69352
Description: Predicted to enable neutral L-amino acid:sodium:chloride symporter activity. Involved in hyperosmotic response. Predicted to be located in apical plasma membrane and brush border membrane. Predicted to be active in plasma membrane. Orthologous to human SLC6A18 (solute carrier family 6 member 18); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: b(0)AT3; MGC93507; renal osmotic stress-induced Na-Cl organic solute cotransporter; Rosit; sodium- and chloride-dependent transporter XTRP2; sodium-dependent neutral amino acid transporter B(0)AT3; solute carrier family 6 (neurotransmitter transporter), member 18; solute carrier family 6 (neutral amino acid transporter), member 18; solute carrier family 6, member 18; system B(0) neutral amino acid transporter AT3; X transporter protein 2; Xtrp2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,436,577 - 31,450,478 (+)NCBIGRCr8
mRatBN7.2129,607,288 - 29,621,925 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,608,077 - 29,621,925 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,409,233 - 29,423,054 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,409,083 - 35,422,904 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,609,861 - 29,623,682 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0132,221,679 - 32,235,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,221,636 - 32,236,051 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,646,546 - 33,660,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,415,234 - 30,429,059 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1130,418,178 - 30,432,004 (+)NCBI
Celera128,256,104 - 28,269,929 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
apical plasma membrane  (IEA,ISO,ISS)
brush border membrane  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Gene regulation of renal-osmotic stress-induced Na-CL organic solute cotransporter. Baba T, etal., Nephron Exp Nephrol. 2004;96(3):e89-96.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
8. Molecular characterization of ROSIT, a renal osmotic stress-induced Na(+)-Cl(-)-organic solute cotransporter. Wasserman JC, etal., Am J Physiol 1994 Oct;267(4 Pt 2):F688-94.
Additional References at PubMed
PMID:9932288   PMID:12477932   PMID:17167413   PMID:19478081   PMID:26240152  


Genomics

Comparative Map Data
Slc6a18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,436,577 - 31,450,478 (+)NCBIGRCr8
mRatBN7.2129,607,288 - 29,621,925 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,608,077 - 29,621,925 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,409,233 - 29,423,054 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,409,083 - 35,422,904 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,609,861 - 29,623,682 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0132,221,679 - 32,235,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,221,636 - 32,236,051 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,646,546 - 33,660,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,415,234 - 30,429,059 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1130,418,178 - 30,432,004 (+)NCBI
Celera128,256,104 - 28,269,929 (+)NCBICelera
Cytogenetic Map1p11NCBI
SLC6A18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3851,225,381 - 1,246,189 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl51,225,381 - 1,246,189 (+)EnsemblGRCh38hg38GRCh38
GRCh3751,225,496 - 1,246,304 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3651,278,470 - 1,299,303 (+)NCBINCBI36Build 36hg18NCBI36
Build 3451,278,469 - 1,299,303NCBI
Celera51,262,353 - 1,283,111 (+)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef51,206,768 - 1,227,774 (+)NCBIHuRef
CHM1_151,225,356 - 1,246,130 (+)NCBICHM1_1
T2T-CHM13v2.051,132,355 - 1,153,096 (+)NCBIT2T-CHM13v2.0
Slc6a18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391373,809,869 - 73,826,142 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1373,809,871 - 73,826,142 (-)EnsemblGRCm39 Ensembl
GRCm381373,661,750 - 73,678,023 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1373,661,752 - 73,678,023 (-)EnsemblGRCm38mm10GRCm38
MGSCv371373,799,198 - 73,815,471 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361374,130,039 - 74,144,003 (-)NCBIMGSCv36mm8
Celera1375,990,742 - 76,006,978 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.13NCBI
Slc6a18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955504634,665 - 644,576 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955504634,615 - 644,667 (+)NCBIChiLan1.0ChiLan1.0
SLC6A18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v241,485,506 - 1,507,595 (+)NCBINHGRI_mPanPan1-v2
PanPan1.1 Ensembl51,272,746 - 1,293,181 (+)Ensemblpanpan1.1panPan2
SLC6A18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,312,172 - 11,327,493 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,290,166 - 11,327,505 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3415,817,657 - 15,837,358 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03411,208,459 - 11,228,159 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3411,190,836 - 11,228,161 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13411,259,258 - 11,278,952 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,243,187 - 11,258,500 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03411,454,210 - 11,469,522 (-)NCBIUU_Cfam_GSD_1.0
Slc6a18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,336,037 - 244,351,884 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936815497,396 - 513,175 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936815497,465 - 513,089 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,277,696 - 79,292,530 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11679,278,126 - 79,292,463 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21685,936,688 - 85,951,025 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.141,054,353 - 1,079,478 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl41,057,136 - 1,075,426 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605435,619,384 - 35,641,717 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc6a18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624751608,766 - 619,213 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624751608,834 - 617,995 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc6a18
83 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:54
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000022346
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat

Markers in Region
RH141691  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,621,644 - 29,621,829 (+)MAPPERmRatBN7.2
Rnor_6.0132,235,313 - 32,235,497NCBIRnor6.0
Rnor_5.0133,660,181 - 33,660,365UniSTSRnor5.0
RGSC_v3.4130,428,779 - 30,428,963UniSTSRGSC3.4
Celera128,269,649 - 28,269,833UniSTS
Cytogenetic Map1p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 29 1
Low 1 1 1 2 17
Below cutoff 1 3 22 6 16 6 7 7 6 4 14 8 7

Sequence


RefSeq Acc Id: ENSRNOT00000022346   ⟹   ENSRNOP00000022346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,608,100 - 29,621,925 (+)Ensembl
Rnor_6.0 Ensembl132,221,636 - 32,236,051 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089941   ⟹   ENSRNOP00000072758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,608,077 - 29,621,546 (+)Ensembl
Rnor_6.0 Ensembl132,221,745 - 32,235,216 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096395   ⟹   ENSRNOP00000088766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,608,100 - 29,621,925 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113926   ⟹   ENSRNOP00000082226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,608,077 - 29,621,546 (+)Ensembl
RefSeq Acc Id: NM_017163   ⟹   NP_058859
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,436,653 - 31,450,478 (+)NCBI
mRatBN7.2129,608,100 - 29,621,925 (+)NCBI
Rnor_6.0132,221,768 - 32,235,593 (+)NCBI
Rnor_5.0133,646,546 - 33,660,461 (+)NCBI
RGSC_v3.4130,415,234 - 30,429,059 (+)RGD
Celera128,256,104 - 28,269,929 (+)RGD
Sequence:
RefSeq Acc Id: XM_006227772   ⟹   XP_006227834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,436,577 - 31,450,474 (+)NCBI
mRatBN7.2129,607,288 - 29,621,921 (+)NCBI
Rnor_6.0132,221,680 - 32,235,599 (+)NCBI
Rnor_5.0133,646,546 - 33,660,461 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006227774   ⟹   XP_006227836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,436,577 - 31,450,474 (+)NCBI
mRatBN7.2129,607,288 - 29,621,921 (+)NCBI
Rnor_6.0132,221,680 - 32,235,599 (+)NCBI
Rnor_5.0133,646,546 - 33,660,461 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006227775   ⟹   XP_006227837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,436,577 - 31,450,474 (+)NCBI
mRatBN7.2129,607,288 - 29,621,921 (+)NCBI
Rnor_6.0132,221,679 - 32,235,599 (+)NCBI
Rnor_5.0133,646,546 - 33,660,461 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039106581   ⟹   XP_038962509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,436,577 - 31,450,474 (+)NCBI
mRatBN7.2129,607,288 - 29,621,921 (+)NCBI
RefSeq Acc Id: XM_063285328   ⟹   XP_063141398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,436,577 - 31,450,474 (+)NCBI
RefSeq Acc Id: XM_063285332   ⟹   XP_063141402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,436,577 - 31,450,474 (+)NCBI
RefSeq Acc Id: XM_063285333   ⟹   XP_063141403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,436,577 - 31,450,474 (+)NCBI
RefSeq Acc Id: NP_058859   ⟸   NM_017163
- UniProtKB: Q62687 (UniProtKB/Swiss-Prot),   G3V847 (UniProtKB/TrEMBL),   A6JUW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227836   ⟸   XM_006227774
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AA48 (UniProtKB/TrEMBL),   A6JUX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227837   ⟸   XM_006227775
- Peptide Label: isoform X7
- UniProtKB: A6JUX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227834   ⟸   XM_006227772
- Peptide Label: isoform X4
- UniProtKB: Q62687 (UniProtKB/Swiss-Prot),   A0A8I5ZTR9 (UniProtKB/TrEMBL),   A6JUX1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072758   ⟸   ENSRNOT00000089941
RefSeq Acc Id: ENSRNOP00000022346   ⟸   ENSRNOT00000022346
RefSeq Acc Id: XP_038962509   ⟸   XM_039106581
- Peptide Label: isoform X5
- UniProtKB: Q5XIV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088766   ⟸   ENSRNOT00000096395
RefSeq Acc Id: ENSRNOP00000082226   ⟸   ENSRNOT00000113926
RefSeq Acc Id: XP_063141398   ⟸   XM_063285328
- Peptide Label: isoform X1
- UniProtKB: Q62687 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063141403   ⟸   XM_063285333
- Peptide Label: isoform X3
- UniProtKB: Q62687 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063141402   ⟸   XM_063285332
- Peptide Label: isoform X2
- UniProtKB: Q62687 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62687-F1-model_v2 AlphaFold Q62687 1-615 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689567
Promoter ID:EPDNEW_R92
Type:multiple initiation site
Name:Slc6a18_1
Description:solute carrier family 6 member 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0132,221,692 - 32,221,752EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69352 AgrOrtholog
BioCyc Gene G2FUF-61928 BioCyc
Ensembl Genes ENSRNOG00000016253 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022346.4 UniProtKB/TrEMBL
  ENSRNOT00000089941.2 UniProtKB/TrEMBL
  ENSRNOT00000096395.1 UniProtKB/TrEMBL
  ENSRNOT00000113926.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110794 IMAGE-MGC_LOAD
InterPro B0AT3_SLC6sbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/ntran_symport UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neutral_aa_SLC6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SNS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29323 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93507 IMAGE-MGC_LOAD
NCBI Gene 29323 ENTREZGENE
PANTHER INACTIVE SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc6a18 PhenoGen
PRINTS NANEUSMPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORPHTRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016253 RatGTEx
Superfamily-SCOP SSF161070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC233124
UniProt A0A8I5ZTR9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AA48 ENTREZGENE, UniProtKB/TrEMBL
  A6JUW9 ENTREZGENE, UniProtKB/TrEMBL
  A6JUX0 ENTREZGENE, UniProtKB/TrEMBL
  A6JUX1 ENTREZGENE, UniProtKB/TrEMBL
  A6JUX2 ENTREZGENE, UniProtKB/TrEMBL
  A6JUX3_RAT UniProtKB/TrEMBL
  G3V847 ENTREZGENE, UniProtKB/TrEMBL
  Q5XIV7 ENTREZGENE, UniProtKB/TrEMBL
  Q62687 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc6a18  solute carrier family 6 member 18  Slc6a18  solute carrier family 6 (neutral amino acid transporter), member 18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc6a18  solute carrier family 6 (neutral amino acid transporter), member 18  Slc6a18  solute carrier family 6, member 18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Slc6a18  solute carrier family 6, member 18  Slc6a18  solute carrier family 6 (neurotransmitter transporter), member 18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc6a18  solute carrier family 6 (neurotransmitter transporter), member 18  Xtrp2  X transporter protein 2  Symbol and Name updated 1299863 APPROVED
2002-06-10 Xtrp2  X transporter protein 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression increased renal mRNA expression is detected in hypernatremic rats 68841