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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1584995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mycn
Name: MYCN proto-oncogene, bHLH transcription factor
Acc ID: CHEBI:79068
Term: crocin-1
Definition: A diester that is crocetin in which both of the carboxy groups have been converted to their gentiobiosyl esters. It is one of the water-soluble yellow-red pigments of saffron and is used as a spice for flavouring and colouring food. Note that in India, the term 'Crocin' is also used by GlaxoSmithKline as a brand-name for paracetamol.
Chemical ID: MESH:C029036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mycndecreases expressionISOMYCN (Homo sapiens)6480464CTDcrocin results in decreased expression of MYCN proteinPMID:30672053
Mycndecreases response to substanceISOMYCN (Homo sapiens)6480464CTDMYCN results in decreased susceptibility to crocinPMID:30672053
Mycnmultiple interactionsISOMYCN (Homo sapiens)6480464CTDcrocin results in decreased expression of and results in decreased stability of MYCN mRNA; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein]PMID:30672053
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