Coq7 (coenzyme Q7, hydroxylase) - Rat Genome Database

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Gene: Coq7 (coenzyme Q7, hydroxylase) Rattus norvegicus
Analyze
Symbol: Coq7
Name: coenzyme Q7, hydroxylase
RGD ID: 2381
Description: Predicted to enable 3-demethoxyubiquinol 3-hydroxylase activity and chromatin binding activity. Involved in response to xenobiotic stimulus and ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Predicted to be part of ubiquinone biosynthesis complex. Predicted to be active in mitochondrial inner membrane and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 9 and primary coenzyme Q10 deficiency 8. Orthologous to human COQ7 (coenzyme Q7, hydroxylase); PARTICIPATES IN ubiquinone biosynthetic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-demethoxyubiquinone hydroxylase, mitochondrial; Coenzyme q (ubiquinone) biosynthetic enzyme (DHPB methyltransferase) 7; coenzyme Q biosynthesis protein 7 homolog; coenzyme Q7 homolog, ubiquinone; coenzyme Q7 homolog, ubiquinone (yeast); demethyl-Q 7; DMQ hydroxylase; timing protein clk-1 homolog; ubiquinone biosynthesis monooxygenase COQ7; ubiquinone biosynthesis protein COQ7 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,270,570 - 182,285,959 (-)NCBIGRCr8
mRatBN7.21172,836,359 - 172,851,173 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1172,835,188 - 172,851,158 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1181,148,907 - 181,163,710 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01188,335,228 - 188,350,029 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,065,025 - 181,079,833 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,176,060 - 188,190,874 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,174,874 - 188,190,860 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01195,122,741 - 195,137,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41176,722,271 - 176,746,436 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11176,880,883 - 176,885,682 (-)NCBI
Celera1170,616,870 - 170,628,144 (-)NCBICelera
Cytogenetic Map1q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proteomic analysis of early left ventricular hypertrophy secondary to hypertension: modulation by antihypertensive therapies. Gallego-Delgado J, etal., J Am Soc Nephrol. 2006 Dec;17(12 Suppl 3):S159-64.
2. Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency. Garcia-Corzo L, etal., Hum Mol Genet. 2013 Mar 15;22(6):1233-48. doi: 10.1093/hmg/dds530. Epub 2012 Dec 18.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Isolation and sequencing of the rat Coq7 gene and the mapping of mouse Coq7 to chromosome 7. Jonassen T, etal., Arch Biochem Biophys 1996 Jun 15;330(2):285-9.
6. Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice. Lapointe J, etal., J Biol Chem. 2009 Jul 24;284(30):20364-74. doi: 10.1074/jbc.M109.006569. Epub 2009 May 28.
7. Microarray analysis of thyroid stimulating hormone, insulin-like growth factor-1, and insulin-induced gene expression in FRTL-5 thyroid cells. Lee YJ, etal., J Korean Med Sci. 2007 Oct;22(5):883-90.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Fenofibrate activates the biochemical pathways and the de novo expression of genes related to lipid handling and uncoupling protein-3 functions in liver of normal rats. Silvestri E, etal., Biochim Biophys Acta. 2006 May-Jun;1757(5-6):486-95. Epub 2006 Mar 23.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. An enhanced immune response of Mclk1(+)/(-) mutant mice is associated with partial protection from fibrosis, cancer and the development of biomarkers of aging. Wang D, etal., PLoS One. 2012;7(11):e49606. doi: 10.1371/journal.pone.0049606. Epub 2012 Nov 14.
18. Lifelong protection from global cerebral ischemia and reperfusion in long-lived Mclk1(+/)(-) mutants. Zheng H, etal., Exp Neurol. 2010 Jun;223(2):557-65. doi: 10.1016/j.expneurol.2010.02.002. Epub 2010 Feb 17.
Additional References at PubMed
PMID:8889548   PMID:11585841   PMID:11716496   PMID:14651853   PMID:18614015   PMID:18635541   PMID:22196358   PMID:25961505  


Genomics

Comparative Map Data
Coq7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,270,570 - 182,285,959 (-)NCBIGRCr8
mRatBN7.21172,836,359 - 172,851,173 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1172,835,188 - 172,851,158 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1181,148,907 - 181,163,710 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01188,335,228 - 188,350,029 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,065,025 - 181,079,833 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,176,060 - 188,190,874 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,174,874 - 188,190,860 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01195,122,741 - 195,137,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41176,722,271 - 176,746,436 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11176,880,883 - 176,885,682 (-)NCBI
Celera1170,616,870 - 170,628,144 (-)NCBICelera
Cytogenetic Map1q35NCBI
COQ7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381619,067,614 - 19,083,097 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1619,067,614 - 19,080,095 (+)EnsemblGRCh38hg38GRCh38
GRCh371619,078,936 - 19,091,417 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361618,986,428 - 18,998,855 (+)NCBINCBI36Build 36hg18NCBI36
Build 341618,986,427 - 18,998,851NCBI
Celera1618,226,796 - 18,239,311 (+)NCBICelera
Cytogenetic Map16p12.3NCBI
HuRef1617,616,329 - 17,628,854 (+)NCBIHuRef
CHM1_11619,166,175 - 19,178,695 (+)NCBICHM1_1
T2T-CHM13v2.01618,998,449 - 19,010,962 (+)NCBIT2T-CHM13v2.0
Coq7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397118,108,881 - 118,132,529 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7118,108,882 - 118,132,579 (-)EnsemblGRCm39 Ensembl
GRCm387118,509,659 - 118,533,356 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7118,509,659 - 118,533,356 (-)EnsemblGRCm38mm10GRCm38
MGSCv377125,668,576 - 125,676,827 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367118,316,211 - 118,324,462 (-)NCBIMGSCv36mm8
Celera7118,482,825 - 118,491,101 (-)NCBICelera
Cytogenetic Map7F1NCBI
cM Map763.44NCBI
Coq7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554423,025,484 - 3,033,582 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554423,026,458 - 3,033,582 (-)NCBIChiLan1.0ChiLan1.0
COQ7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21820,331,589 - 20,343,307 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11624,855,106 - 24,870,763 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01619,229,649 - 19,242,131 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11619,172,134 - 19,184,158 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1619,172,135 - 19,184,158 (+)Ensemblpanpan1.1panPan2
COQ7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1625,912,936 - 25,922,123 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl625,912,954 - 25,929,655 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha627,278,749 - 27,291,703 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0626,062,369 - 26,085,094 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl626,067,721 - 26,076,911 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1625,862,208 - 25,885,081 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0625,756,684 - 25,779,046 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0626,146,453 - 26,169,135 (+)NCBIUU_Cfam_GSD_1.0
Coq7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344116,938,126 - 116,946,011 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365015,034,224 - 5,043,909 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365015,035,986 - 5,043,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COQ7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl326,366,000 - 26,373,584 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1326,366,006 - 26,373,604 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
COQ7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1517,351,429 - 17,362,305 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl517,351,506 - 17,362,916 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606812,568,477 - 12,580,312 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Coq7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247822,682,486 - 2,689,661 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247822,682,489 - 2,689,662 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Coq7
64 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:485
Count of miRNA genes:259
Interacting mature miRNAs:321
Transcripts:ENSRNOT00000022988
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
D1Got328  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21172,824,397 - 172,824,494 (+)MAPPERmRatBN7.2
Rnor_6.01188,164,101 - 188,164,197NCBIRnor6.0
Rnor_5.01195,110,782 - 195,110,878UniSTSRnor5.0
RGSC_v3.41176,729,677 - 176,729,773UniSTSRGSC3.4
Celera1170,604,910 - 170,605,006UniSTS
Cytogenetic Map1q35UniSTS
RH134107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21172,836,451 - 172,837,174 (+)MAPPERmRatBN7.2
Rnor_6.01188,176,153 - 188,176,875NCBIRnor6.0
Rnor_5.01195,122,834 - 195,123,556UniSTSRnor5.0
RGSC_v3.41176,741,729 - 176,742,451UniSTSRGSC3.4
Celera1170,616,963 - 170,617,685UniSTS
RH 3.4 Map11378.1UniSTS
Cytogenetic Map1q35UniSTS
BF387931  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21172,830,332 - 172,830,485 (+)MAPPERmRatBN7.2
Rnor_6.01188,170,034 - 188,170,186NCBIRnor6.0
Rnor_5.01195,116,715 - 195,116,867UniSTSRnor5.0
RGSC_v3.41176,735,610 - 176,735,762UniSTSRGSC3.4
Celera1170,610,843 - 170,610,995UniSTS
RH 3.4 Map11378.89UniSTS
Cytogenetic Map1q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000022988   ⟹   ENSRNOP00000022988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1172,835,188 - 172,851,158 (-)Ensembl
Rnor_6.0 Ensembl1188,174,874 - 188,190,860 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1188,180,529 - 188,190,845 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1188,180,462 - 188,190,836 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092657   ⟹   ENSRNOP00000075851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1188,178,527 - 188,190,778 (-)Ensembl
RefSeq Acc Id: NM_012785   ⟹   NP_036917
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,270,570 - 182,285,369 (-)NCBI
mRatBN7.21172,836,359 - 172,851,158 (-)NCBI
Rnor_6.01188,176,060 - 188,190,860 (-)NCBI
Rnor_5.01195,122,741 - 195,137,551 (-)NCBI
RGSC_v3.41176,722,271 - 176,746,436 (-)RGD
Celera1170,616,870 - 170,628,144 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230108   ⟹   XP_006230170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,270,574 - 182,285,384 (-)NCBI
mRatBN7.21172,836,359 - 172,851,167 (-)NCBI
Rnor_6.01188,176,060 - 188,190,874 (-)NCBI
Rnor_5.01195,122,741 - 195,137,551 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101527   ⟹   XP_038957455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,272,980 - 182,285,959 (-)NCBI
mRatBN7.21172,838,737 - 172,851,173 (-)NCBI
RefSeq Acc Id: XM_063281526   ⟹   XP_063137596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,270,574 - 182,285,390 (-)NCBI
RefSeq Acc Id: XM_063281528   ⟹   XP_063137598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,270,574 - 182,285,394 (-)NCBI
RefSeq Acc Id: XM_063281533   ⟹   XP_063137603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,270,574 - 182,275,368 (-)NCBI
RefSeq Acc Id: NP_036917   ⟸   NM_012785
- UniProtKB: Q63619 (UniProtKB/Swiss-Prot),   O08887 (UniProtKB/Swiss-Prot),   G3V879 (UniProtKB/TrEMBL),   A6I8H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230170   ⟸   XM_006230108
- Peptide Label: isoform X3
- UniProtKB: A6I8H4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075851   ⟸   ENSRNOT00000092657
Ensembl Acc Id: ENSRNOP00000022988   ⟸   ENSRNOT00000022988
RefSeq Acc Id: XP_038957455   ⟸   XM_039101527
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063137598   ⟸   XM_063281528
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063137596   ⟸   XM_063281526
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063137603   ⟸   XM_063281533
- Peptide Label: isoform X4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63619-F1-model_v2 AlphaFold Q63619 1-179 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690344
Promoter ID:EPDNEW_R865
Type:multiple initiation site
Name:Coq7_1
Description:coenzyme Q7, hydroxylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,190,855 - 188,190,915EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2381 AgrOrtholog
BioCyc Gene G2FUF-57681 BioCyc
BioCyc Pathway PWY-5871 [ubiquinol-9 biosynthesis (late decarboxylation)] BioCyc
BioCyc Pathway Image PWY-5871 BioCyc
Ensembl Genes ENSRNOG00000017012 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022988.6 UniProtKB/TrEMBL
InterPro Ferritin-like_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubq_synth_Coq7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25249 UniProtKB/TrEMBL
NCBI Gene 25249 ENTREZGENE
PANTHER 5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11237 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COQ7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Coq7 PhenoGen
RatGTEx ENSRNOG00000017012 RatGTEx
Superfamily-SCOP SSF47240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205709
UniProt A6I8H3 ENTREZGENE, UniProtKB/TrEMBL
  A6I8H4 ENTREZGENE, UniProtKB/TrEMBL
  COQ7_RAT UniProtKB/Swiss-Prot
  G3V879 ENTREZGENE, UniProtKB/TrEMBL
  O08887 ENTREZGENE
  Q63619 ENTREZGENE
UniProt Secondary O08887 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Coq7  coenzyme Q7, hydroxylase  Coq7  coenzyme Q7 homolog, ubiquinone (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-15 Coq7  coenzyme Q7 homolog, ubiquinone (yeast)  Coq7  demethyl-Q 7   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Coq7  demethyl-Q 7       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function functionally complements an S. cerevisiae coq7 deletion mutant 69815