Fancc (FA complementation group C) - Rat Genome Database

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Gene: Fancc (FA complementation group C) Rattus norvegicus
Analyze
Symbol: Fancc
Name: FA complementation group C
RGD ID: 2593
Description: Predicted to be involved in cellular response to oxidative stress; nucleotide-excision repair; and protein monoubiquitination. Predicted to act upstream of or within several processes, including brain morphogenesis; neuronal stem cell population maintenance; and removal of superoxide radicals. Located in chromatin. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); acute myeloid leukemia; aspirin-induced respiratory disease; pancreatic cancer; and pancytopenia. Orthologous to human FANCC (FA complementation group C); INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Facc; Fanconi anemia group C; fanconi anemia group C protein homolog; Fanconi anemia, complementation group C; LOC103694020; uncharacterized LOC103694020
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2171,680,660 - 1,822,610 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl171,681,324 - 1,829,376 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx171,700,069 - 1,822,177 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0173,242,667 - 3,364,775 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0171,697,517 - 1,819,627 (+)NCBIRnor_WKY
Rnor_6.017826,512 - 955,703 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17833,509 - 955,615 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.017819,325 - 948,712 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,254,528 - 7,341,500 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1177,254,527 - 7,341,497 (+)NCBI
Celera17719,268 - 841,089 (-)NCBICelera
RH 3.4 Map175.6RGD
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlorambucil  (ISO)
cisplatin  (ISO)
cypermethrin  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
epoxiconazole  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
hydrogen peroxide  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
melphalan  (ISO)
methapyrilene  (ISO)
N-ethyl-N-nitrosourea  (ISO)
ochratoxin A  (EXP)
ozone  (ISO)
paracetamol  (EXP)
pentachlorophenol  (ISO)
phosphoramide mustard  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
resveratrol  (EXP)
riddelliine  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IDA,ISO)
cytoplasm  (IEA)
cytosol  (ISO)
Fanconi anaemia nuclear complex  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Constitutional sequence variation in the Fanconi anaemia group C (FANCC) gene in childhood acute myeloid leukaemia. Barber LM, etal., Br J Haematol. 2003 Apr;121(1):57-62.
2. Bone marrow failure in the Fanconi anemia group C mouse model after DNA damage. Carreau M, etal., Blood. 1998 Apr 15;91(8):2737-44.
3. Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia. Chen M, etal., Nat Genet 1996 Apr;12(4):448-51.
4. Cloning of the bovine and rat Fanconi anemia group C cDNA. Ching Ying Wong J, etal., Mamm Genome 1997 Jul;8(7):522-5.
5. Germ line Fanconi anemia complementation group C mutations and pancreatic cancer. Couch FJ, etal., Cancer Res. 2005 Jan 15;65(2):383-6.
6. Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group. Faivre L, etal., Blood. 2000 Dec 15;96(13):4064-70.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. A Leu554-to-Pro substitution completely abolishes the functional complementing activity of the Fanconi anemia (FACC) protein. Gavish H, etal., Hum Mol Genet 1993 Feb;2(2):123-6.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Phenotypic correction of Fanconi anemia group C knockout mice. Gush KA, etal., Blood. 2000 Jan 15;95(2):700-4.
11. Association of FANCC polymorphisms with FEV1 decline in aspirin exacerbated respiratory disease. Kim JH, etal., Mol Biol Rep. 2012 Mar;39(3):2385-94. doi: 10.1007/s11033-011-0989-6. Epub 2011 Jun 14.
12. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13. Fanconi anemia links reactive oxygen species to insulin resistance and obesity. Li J, etal., Antioxid Redox Signal. 2012 Oct 15;17(8):1083-98. doi: 10.1089/ars.2011.4417. Epub 2012 Jun 25.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. The Fanconi anemia core complex associates with chromatin during S phase. Mi J and Kupfer GM, Blood 2005 Jan 15;105(2):759-66. Epub 2004 Jul 15.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Inflammatory reactive oxygen species-mediated hemopoietic suppression in Fancc-deficient mice. Sejas DP, etal., J Immunol. 2007 Apr 15;178(8):5277-87.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Exome sequencing identifies rare deleterious mutations in DNA repair genes FANCC and BLM as potential breast cancer susceptibility alleles. Thompson ER, etal., PLoS Genet. 2012 Sep;8(9):e1002894. doi: 10.1371/journal.pgen.1002894. Epub 2012 Sep 27.
25. In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor. van der Heijden MS, etal., Clin Cancer Res. 2005 Oct 15;11(20):7508-15.
26. Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene. Whitney MA, etal., Blood 1996 Jul 1;88(1):49-58.
27. Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma. Wreesmann VB, etal., ORL J Otorhinolaryngol Relat Spec. 2007;69(4):218-25. Epub 2007 Apr 4.
28. Novel inactivating mutations of FANCC in Brazilian patients with Fanconi anemia. Yates J, etal., Hum Mutat. 2006 Feb;27(2):214.
Additional References at PubMed
PMID:9596688   PMID:11493445   PMID:12477932   PMID:20347428   PMID:22266823   PMID:24483844  


Genomics

Comparative Map Data
Fancc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2171,680,660 - 1,822,610 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl171,681,324 - 1,829,376 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx171,700,069 - 1,822,177 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0173,242,667 - 3,364,775 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0171,697,517 - 1,819,627 (+)NCBIRnor_WKY
Rnor_6.017826,512 - 955,703 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17833,509 - 955,615 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.017819,325 - 948,712 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,254,528 - 7,341,500 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1177,254,527 - 7,341,497 (+)NCBI
Celera17719,268 - 841,089 (-)NCBICelera
RH 3.4 Map175.6RGD
Cytogenetic Map17p14NCBI
FANCC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38995,099,054 - 95,317,709 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl995,099,054 - 95,426,796 (-)EnsemblGRCh38hg38GRCh38
GRCh37997,861,336 - 98,079,991 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36996,901,157 - 97,119,812 (-)NCBINCBI36Build 36hg18NCBI36
Build 34994,940,890 - 95,159,546NCBI
Celera968,302,367 - 68,521,048 (-)NCBICelera
Cytogenetic Map9q22.32NCBI
HuRef967,470,857 - 67,689,280 (-)NCBIHuRef
CHM1_1998,007,791 - 98,226,463 (-)NCBICHM1_1
T2T-CHM13v2.09107,268,451 - 107,487,223 (-)NCBIT2T-CHM13v2.0
Fancc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391363,452,519 - 63,645,126 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1363,432,857 - 63,645,092 (-)EnsemblGRCm39 Ensembl
GRCm381363,301,334 - 63,497,292 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1363,285,043 - 63,497,278 (-)EnsemblGRCm38mm10GRCm38
MGSCv371363,406,017 - 63,533,053 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361363,320,977 - 63,440,947 (-)NCBIMGSCv36mm8
Celera1364,958,890 - 65,084,928 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1332.8NCBI
Fancc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542222,032,258 - 22,247,044 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542222,031,825 - 22,246,478 (-)NCBIChiLan1.0ChiLan1.0
FANCC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1994,327,355 - 94,544,772 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl994,329,971 - 94,477,198 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0966,201,581 - 66,418,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FANCC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1171,388,931 - 71,678,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl171,487,601 - 71,678,506 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha172,151,677 - 72,440,952 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0171,693,614 - 71,983,350 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl171,788,781 - 71,973,067 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1171,505,368 - 71,794,755 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0171,269,071 - 71,558,824 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0171,975,513 - 72,265,108 (+)NCBIUU_Cfam_GSD_1.0
Fancc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049444,751,995 - 4,931,679 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366263,980,311 - 4,147,042 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FANCC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1026,796,572 - 27,061,801 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11026,796,546 - 27,055,271 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,282,173 - 31,315,897 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FANCC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112107,780,087 - 107,991,828 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12107,845,135 - 107,991,237 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603896,155,447 - 96,377,196 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fancc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475316,566,864 - 16,811,438 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
D17Got229  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2171,779,376 - 1,779,497 (-)MAPPERmRatBN7.2
Rnor_6.017857,487 - 857,607NCBIRnor6.0
Rnor_5.017850,440 - 850,560UniSTSRnor5.0
RGSC_v3.4177,317,343 - 7,317,463UniSTSRGSC3.4
Celera17743,288 - 743,408UniSTS
Cytogenetic Map17p14UniSTS
RH94652  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2171,803,299 - 1,803,455 (-)MAPPERmRatBN7.2
Rnor_6.017833,529 - 833,684NCBIRnor6.0
Rnor_5.017826,342 - 826,497UniSTSRnor5.0
RGSC_v3.4177,341,322 - 7,341,477UniSTSRGSC3.4
Celera17719,291 - 719,446UniSTS
RH 3.4 Map175.6UniSTS
Cytogenetic Map17p14UniSTS
RH141857  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2171,803,246 - 1,803,432 (-)MAPPERmRatBN7.2
Rnor_6.017833,552 - 833,737NCBIRnor6.0
Rnor_5.017826,365 - 826,550UniSTSRnor5.0
RGSC_v3.4177,341,269 - 7,341,454UniSTSRGSC3.4
Celera17719,314 - 719,499UniSTS
RH 3.4 Map1723.2UniSTS
Cytogenetic Map17p14UniSTS
Fanccrgdv551196202-C  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.017946,321 - 946,321 (-)RGDRnor6.0
Rnor_5.017939,418 - 939,418 (-)RGDRnor5.0
RGSC_v3.4177,228,496 - 7,228,496 (+)RGDRGSC3.4


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:82
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000022884
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 11 4 9 4 14 22 28 2
Low 3 39 46 37 10 37 8 11 60 13 13 9 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001841732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005495234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005495235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005495236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC134760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC168147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U73586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000022884   ⟹   ENSRNOP00000022884
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl171,681,324 - 1,803,468 (+)Ensembl
Rnor_6.0 Ensembl17833,509 - 955,615 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094085   ⟹   ENSRNOP00000092010
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl171,681,324 - 1,803,468 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095403   ⟹   ENSRNOP00000084889
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl171,681,324 - 1,829,376 (+)Ensembl
RefSeq Acc Id: NM_012557   ⟹   NP_036689
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,681,361 - 1,803,478 (+)NCBI
Rnor_6.017833,506 - 955,615 (-)NCBI
Rnor_5.017819,325 - 948,712 (-)NCBI
RGSC_v3.4177,254,528 - 7,341,500 (+)RGD
Celera17719,268 - 841,089 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253488   ⟹   XP_006253550
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,681,642 - 1,810,500 (+)NCBI
Rnor_6.017826,512 - 923,430 (-)NCBI
Rnor_5.017819,325 - 948,712 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253489   ⟹   XP_006253551
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,680,663 - 1,810,500 (+)NCBI
Rnor_6.017826,512 - 923,430 (-)NCBI
Rnor_5.017819,325 - 948,712 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253491   ⟹   XP_006253553
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,739,766 - 1,810,500 (+)NCBI
Rnor_6.017826,512 - 897,149 (-)NCBI
Rnor_5.017819,325 - 948,712 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771423   ⟹   XP_008769645
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,681,110 - 1,810,500 (+)NCBI
Rnor_6.017826,512 - 955,703 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095340   ⟹   XP_038951268
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,680,660 - 1,810,500 (+)NCBI
RefSeq Acc Id: XM_039095341   ⟹   XP_038951269
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,681,110 - 1,810,500 (+)NCBI
RefSeq Acc Id: XR_001841732
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,680,661 - 1,822,610 (+)NCBI
Rnor_6.017826,512 - 923,430 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005495234
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,680,661 - 1,822,610 (+)NCBI
RefSeq Acc Id: XR_005495235
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,680,661 - 1,822,610 (+)NCBI
RefSeq Acc Id: XR_005495236
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,680,661 - 1,822,610 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036689   ⟸   NM_012557
- UniProtKB: B4F762 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253551   ⟸   XM_006253489
- Peptide Label: isoform X2
- UniProtKB: B4F762 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253550   ⟸   XM_006253488
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006253553   ⟸   XM_006253491
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008769645   ⟸   XM_008771423
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000022884   ⟸   ENSRNOT00000022884
RefSeq Acc Id: XP_038951268   ⟸   XM_039095340
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038951269   ⟸   XM_039095341
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000084889   ⟸   ENSRNOT00000095403
RefSeq Acc Id: ENSRNOP00000092010   ⟸   ENSRNOT00000094085

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35870-F1-model_v2 AlphaFold O35870 1-557 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2593 AgrOrtholog
BioCyc Gene G2FUF-10527 BioCyc
Ensembl Genes ENSRNOG00000016889 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022884 ENTREZGENE
  ENSRNOP00000022884.5 UniProtKB/TrEMBL
  ENSRNOP00000084889.1 UniProtKB/TrEMBL
  ENSRNOP00000092010 ENTREZGENE
  ENSRNOP00000092010.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022884 ENTREZGENE
  ENSRNOT00000022884.7 UniProtKB/TrEMBL
  ENSRNOT00000094085 ENTREZGENE
  ENSRNOT00000094085.1 UniProtKB/TrEMBL
  ENSRNOT00000095403.1 UniProtKB/TrEMBL
InterPro FANCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24361 UniProtKB/TrEMBL
NCBI Gene 24361 ENTREZGENE
PANTHER PTHR16798 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fanconi_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fancc PhenoGen
PIRSF FACC_protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FANCONICGENE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC235798
UniProt A0A8I6A237_RAT UniProtKB/TrEMBL
  A0A8I6AGC3_RAT UniProtKB/TrEMBL
  B4F762 ENTREZGENE, UniProtKB/TrEMBL
  F7EZC4_RAT UniProtKB/TrEMBL
  FANCC_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fancc  FA complementation group C  LOC103694020  uncharacterized LOC103694020  Data Merged 737654 PROVISIONAL
2018-05-25 Fancc  FA complementation group C  Fancc  Fanconi anemia, complementation group C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103694020  uncharacterized LOC103694020      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Fancc  Fanconi anemia group C      Symbol and Name status set to approved 70586 APPROVED