Nudt15 (nudix hydrolase 15) - Rat Genome Database

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Gene: Nudt15 (nudix hydrolase 15) Rattus norvegicus
Analyze
Symbol: Nudt15
Name: nudix hydrolase 15
RGD ID: 1308292
Description: Predicted to enable 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity; and 8-oxo-dGDP phosphatase activity. Predicted to be involved in several processes, including DNA protection; dGTP catabolic process; and regulation of proteasomal protein catabolic process. Predicted to act upstream of or within purine deoxyribonucleoside triphosphate catabolic process and response to reactive oxygen species. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in thiopurine S-methyltransferase deficiency. Orthologous to human NUDT15 (nudix hydrolase 15); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC290365; nucleotide triphosphate diphosphatase NUDT15; nudix (nucleoside diphosphate linked moiety X)-type motif 15; probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; probable 8-oxo-dGTP diphosphatase NUDT15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81555,117,312 - 55,123,983 (-)NCBIGRCr8
mRatBN7.21548,707,776 - 48,713,847 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1548,709,700 - 48,747,363 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1552,851,229 - 52,857,306 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01553,962,806 - 53,968,883 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01550,805,521 - 50,811,622 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01555,417,774 - 55,456,698 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1555,419,502 - 55,456,698 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01559,139,985 - 59,178,909 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41554,171,542 - 54,209,265 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11554,187,267 - 54,191,468 (-)NCBI
Celera1548,358,114 - 48,395,646 (-)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12767940   PMID:19419956   PMID:22556419   PMID:26238318   PMID:26878724  


Genomics

Comparative Map Data
Nudt15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81555,117,312 - 55,123,983 (-)NCBIGRCr8
mRatBN7.21548,707,776 - 48,713,847 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1548,709,700 - 48,747,363 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1552,851,229 - 52,857,306 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01553,962,806 - 53,968,883 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01550,805,521 - 50,811,622 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01555,417,774 - 55,456,698 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1555,419,502 - 55,456,698 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01559,139,985 - 59,178,909 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41554,171,542 - 54,209,265 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11554,187,267 - 54,191,468 (-)NCBI
Celera1548,358,114 - 48,395,646 (-)NCBICelera
Cytogenetic Map15q11NCBI
NUDT15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381348,037,726 - 48,052,755 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1348,037,726 - 48,047,221 (+)EnsemblGRCh38hg38GRCh38
GRCh371348,611,862 - 48,626,891 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,509,704 - 47,519,283 (+)NCBINCBI36Build 36hg18NCBI36
Build 341347,509,703 - 47,519,283NCBI
Celera1329,666,454 - 29,676,033 (+)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1329,404,604 - 29,414,174 (+)NCBIHuRef
CHM1_11348,579,420 - 48,589,016 (+)NCBICHM1_1
T2T-CHM13v2.01347,258,119 - 47,273,139 (+)NCBIT2T-CHM13v2.0
Nudt15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391473,756,320 - 73,785,682 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1473,756,317 - 73,785,682 (-)EnsemblGRCm39 Ensembl
GRCm381473,518,880 - 73,548,242 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1473,518,877 - 73,548,242 (-)EnsemblGRCm38mm10GRCm38
MGSCv371473,919,671 - 73,948,049 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361472,254,019 - 72,282,397 (-)NCBIMGSCv36mm8
Celera259,869,585 - 59,872,692 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1439.06NCBI
Nudt15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554311,767,525 - 1,775,555 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554311,767,971 - 1,775,555 (+)NCBIChiLan1.0ChiLan1.0
NUDT15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21449,489,212 - 49,498,400 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11348,140,421 - 48,149,612 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01329,189,459 - 29,198,825 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11347,891,558 - 47,900,977 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1347,891,557 - 47,900,971 (+)Ensemblpanpan1.1panPan2
NUDT15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1223,416,702 - 3,424,607 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl223,416,578 - 3,424,409 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha223,445,175 - 3,453,057 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0223,530,619 - 3,538,511 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl223,528,270 - 3,538,343 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1223,315,298 - 3,323,228 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0223,378,543 - 3,386,433 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0223,383,421 - 3,391,341 (-)NCBIUU_Cfam_GSD_1.0
Nudt15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945157,897,573 - 157,905,976 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365651,381,655 - 1,389,048 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365651,380,981 - 1,389,908 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUDT15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,572,644 - 19,584,528 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,572,963 - 19,584,565 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21120,025,215 - 20,037,485 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUDT15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1325,966,148 - 25,974,143 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl325,966,876 - 25,973,647 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605717,957,744 - 17,993,065 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nudt15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247486,804,740 - 6,823,757 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247486,807,667 - 6,824,477 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nudt15
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000038436
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000038436   ⟹   ENSRNOP00000034570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1548,709,700 - 48,747,363 (-)Ensembl
Rnor_6.0 Ensembl1555,419,698 - 55,456,698 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077733   ⟹   ENSRNOP00000072456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1555,419,502 - 55,424,024 (-)Ensembl
RefSeq Acc Id: NM_001106049   ⟹   NP_001099519
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81555,117,312 - 55,123,383 (-)NCBI
mRatBN7.21548,707,776 - 48,713,847 (-)NCBI
Rnor_6.01555,419,698 - 55,456,698 (-)NCBI
Rnor_5.01559,139,985 - 59,178,909 (-)NCBI
RGSC_v3.41554,171,542 - 54,209,265 (-)RGD
Celera1548,358,114 - 48,395,646 (-)RGD
Sequence:
RefSeq Acc Id: XM_063274151   ⟹   XP_063130221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81555,117,312 - 55,123,983 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099519 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130221 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02271 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034570.4
RefSeq Acc Id: NP_001099519   ⟸   NM_001106049
- UniProtKB: D3ZKQ0 (UniProtKB/TrEMBL),   A6HTQ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034570   ⟸   ENSRNOT00000038436
Ensembl Acc Id: ENSRNOP00000072456   ⟸   ENSRNOT00000077733
RefSeq Acc Id: XP_063130221   ⟸   XM_063274151
- Peptide Label: isoform X1
Protein Domains
Nudix hydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKQ0-F1-model_v2 AlphaFold D3ZKQ0 1-170 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308292 AgrOrtholog
BioCyc Gene G2FUF-13161 BioCyc
BioCyc Pathway PWY-6502 [8-oxo-(d)GTP detoxification I] BioCyc
BioCyc Pathway Image PWY-6502 BioCyc
Ensembl Genes ENSRNOG00000025239 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038436.5 UniProtKB/TrEMBL
Gene3D-CATH Nucleoside Triphosphate Pyrophosphohydrolase UniProtKB/TrEMBL
InterPro Nudix_hydrolase UniProtKB/TrEMBL
  NUDIX_hydrolase_CS UniProtKB/TrEMBL
  NUDIX_hydrolase_dom UniProtKB/TrEMBL
  NUDIX_hydrolase_dom-like UniProtKB/TrEMBL
KEGG Report rno:290365 UniProtKB/TrEMBL
NCBI Gene 290365 ENTREZGENE
PANTHER 8-OXO-DGTP DIPHOSPHATES NUDT15 UniProtKB/TrEMBL
  NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15 UniProtKB/TrEMBL
Pfam NUDIX UniProtKB/TrEMBL
PhenoGen Nudt15 PhenoGen
PRINTS NUDIXFAMILY UniProtKB/TrEMBL
PROSITE NUDIX UniProtKB/TrEMBL
  NUDIX UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025239 RatGTEx
Superfamily-SCOP NUDIX_hydrolase UniProtKB/TrEMBL
UniProt A6HTQ8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZKQ0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Nudt15  nudix hydrolase 15  Nudt15  nudix (nucleoside diphosphate linked moiety X)-type motif 15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nudt15  nudix (nucleoside diphosphate linked moiety X)-type motif 15   Nudt15_predicted  nudix (nucleoside diphosphate linked moiety X)-type motif 15 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nudt15_predicted  nudix (nucleoside diphosphate linked moiety X)-type motif 15 (predicted)      Symbol and Name status set to approved 70820 APPROVED