Atp1a4 (ATPase Na+/K+ transporting subunit alpha 4) - Rat Genome Database

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Gene: Atp1a4 (ATPase Na+/K+ transporting subunit alpha 4) Rattus norvegicus
Analyze
Symbol: Atp1a4
Name: ATPase Na+/K+ transporting subunit alpha 4
RGD ID: 61952
Description: Enables P-type sodium:potassium-exchanging transporter activity. Involved in flagellated sperm motility; regulation of cellular pH; and spermatogenesis. Predicted to be located in rod photoreceptor outer segment and sperm midpiece. Predicted to be part of sodium:potassium-exchanging ATPase complex. Predicted to be active in cell projection and plasma membrane. Orthologous to human ATP1A4 (ATPase Na+/K+ transporting subunit alpha 4); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATPase, Na+/K+ transporting, alpha 4 polypeptide; LOC100365885; MGC93426; na(+)/K(+) ATPase alpha-4 subunit; sodium pump subunit alpha-4; sodium/potassium-transporting ATPase subunit alpha-4; sodium/potassium-transporting ATPase subunit alpha-4-like
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21384,683,766 - 84,719,790 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,683,768 - 84,719,687 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1387,187,089 - 87,223,004 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01388,587,350 - 88,623,276 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01385,772,091 - 85,807,950 (-)NCBIRnor_WKY
Rnor_6.01390,605,792 - 90,642,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,605,794 - 90,641,772 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,126,899 - 95,163,433 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,213,848 - 88,249,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,402,731 - 88,437,959 (-)NCBI
Celera1384,295,133 - 84,329,808 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
aldosterone signaling pathway  (IEA)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis. Shamraj OI and Lingrel JB, Proc Natl Acad Sci U S A 1994 Dec 20;91(26):12952-6.
10. The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1. Underhill DA, etal., Biochemistry. 1999 Nov 9;38(45):14746-51.
11. Different expression and activity of the alpha1 and alpha4 isoforms of the Na,K-ATPase during rat male germ cell ontogeny. Wagoner K, etal., Reproduction. 2005 Nov;130(5):627-41.
12. Roles of the Na,K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility. Woo AL, etal., Mol Reprod Dev 2002 Jul;62(3):348-56.
Additional References at PubMed
PMID:12477932   PMID:12763881   PMID:16861705   PMID:20179187   PMID:20826726   PMID:21187400   PMID:22441762   PMID:23229519   PMID:26373354   PMID:26476261   PMID:27599714   PMID:30053369  


Genomics

Comparative Map Data
Atp1a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21384,683,766 - 84,719,790 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,683,768 - 84,719,687 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1387,187,089 - 87,223,004 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01388,587,350 - 88,623,276 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01385,772,091 - 85,807,950 (-)NCBIRnor_WKY
Rnor_6.01390,605,792 - 90,642,032 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,605,794 - 90,641,772 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,126,899 - 95,163,433 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,213,848 - 88,249,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,402,731 - 88,437,959 (-)NCBI
Celera1384,295,133 - 84,329,808 (-)NCBICelera
Cytogenetic Map13q24NCBI
ATP1A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,151,603 - 160,186,980 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1160,151,586 - 160,186,980 (+)EnsemblGRCh38hg38GRCh38
GRCh371160,121,393 - 160,156,770 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,387,976 - 158,423,391 (+)NCBINCBI36Build 36hg18NCBI36
Build 341156,934,435 - 156,969,836NCBI
Celera1133,190,120 - 133,225,532 (+)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,478,471 - 131,513,484 (+)NCBIHuRef
CHM1_11161,516,689 - 161,552,120 (+)NCBICHM1_1
T2T-CHM13v2.01159,288,690 - 159,324,059 (+)NCBIT2T-CHM13v2.0
Atp1a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,051,075 - 172,085,991 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,051,080 - 172,085,981 (-)EnsemblGRCm39 Ensembl
GRCm381172,223,508 - 172,258,424 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,223,513 - 172,258,414 (-)EnsemblGRCm38mm10GRCm38
MGSCv371174,153,639 - 174,188,555 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1175,079,480 - 175,114,351 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.54NCBI
ATP1A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11139,426,556 - 139,462,393 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1139,426,556 - 139,462,393 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01135,504,929 - 135,540,651 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC101966280
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050586,275,960 - 6,308,838 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936740445,952 - 478,532 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936740445,952 - 478,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,759,509 - 3,794,106 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl203,759,597 - 3,793,980 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660382,816,977 - 2,852,218 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp1a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247941,068,056 - 1,108,303 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp1a4
118 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:209
Count of miRNA genes:155
Interacting mature miRNAs:177
Transcripts:ENSRNOT00000064601
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 16 15 4 4 10 12 6 7 4
Below cutoff 3 15 26 26 4 26 4 7 29 13 15 4 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000064601   ⟹   ENSRNOP00000062079
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1384,683,768 - 84,719,687 (-)Ensembl
Rnor_6.0 Ensembl1390,605,794 - 90,641,772 (-)Ensembl
RefSeq Acc Id: NM_001271030   ⟹   NP_001257959
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21384,683,768 - 84,719,687 (-)NCBI
Rnor_6.01390,605,794 - 90,641,772 (-)NCBI
Rnor_5.01395,126,899 - 95,163,433 (-)NCBI
Celera1384,295,133 - 84,329,808 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022848   ⟹   NP_074039
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21384,683,768 - 84,719,687 (-)NCBI
Rnor_6.01390,605,794 - 90,641,772 (-)NCBI
Rnor_5.01395,126,899 - 95,163,433 (-)NCBI
RGSC_v3.41388,213,848 - 88,249,075 (-)RGD
Celera1384,295,133 - 84,329,808 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598762   ⟹   XP_017454251
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21384,683,766 - 84,719,790 (-)NCBI
Rnor_6.01390,605,792 - 90,642,032 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001257959 (Get FASTA)   NCBI Sequence Viewer  
  NP_074039 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454251 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB81285 (Get FASTA)   NCBI Sequence Viewer  
  AAH87015 (Get FASTA)   NCBI Sequence Viewer  
  Q64541 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_074039   ⟸   NM_022848
- UniProtKB: Q64541 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257959   ⟸   NM_001271030
- UniProtKB: Q64541 (UniProtKB/Swiss-Prot),   Q5PQV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454251   ⟸   XM_017598762
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000062079   ⟸   ENSRNOT00000064601
Protein Domains
Cation_ATPase_N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64541-F1-model_v2 AlphaFold Q64541 1-1028 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699023
Promoter ID:EPDNEW_R9548
Type:initiation region
Name:Atp1a4_1
Description:ATPase Na+/K+ transporting subunit alpha 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01390,641,776 - 90,641,836EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61952 AgrOrtholog
BioCyc Gene G2FUF-17327 BioCyc
Ensembl Genes ENSRNOG00000032378 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000062079 ENTREZGENE
  ENSRNOP00000062079.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064601 ENTREZGENE
  ENSRNOT00000064601.4 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7113151 IMAGE-MGC_LOAD
InterPro ATPase_P-typ_cation-transptr_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_cation-transptr_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-type_ATPase_IIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29132 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93426 IMAGE-MGC_LOAD
NCBI Gene 29132 ENTREZGENE
Pfam Cation_ATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cation_ATPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp1a4 PhenoGen
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Cation_ATPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81653 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs ATPase-IIC_X-K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AT1A4_RAT UniProtKB/Swiss-Prot
  Q5PQV3 ENTREZGENE, UniProtKB/TrEMBL
  Q64541 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp1a4  ATPase Na+/K+ transporting subunit alpha 4  Atp1a4  ATPase, Na+/K+ transporting, alpha 4 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-12 Atp1a4  ATPase, Na+/K+ transporting, alpha 4 polypeptide  LOC100365885  sodium/potassium-transporting ATPase subunit alpha-4-like  Data Merged 737654 PROVISIONAL
2010-05-05 LOC100365885  sodium/potassium-transporting ATPase subunit alpha-4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Atp1a4  ATPase, Na+/K+ transporting, alpha 4 polypeptide      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference