Nkd2 (NKD inhibitor of WNT signaling pathway 2) - Rat Genome Database

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Gene: Nkd2 (NKD inhibitor of WNT signaling pathway 2) Rattus norvegicus
Analyze
Symbol: Nkd2
Name: NKD inhibitor of WNT signaling pathway 2
RGD ID: 1311459
Description: Predicted to enable several functions, including enzyme binding activity; growth factor binding activity; and myosin heavy chain binding activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of protein localization to plasma membrane; and positive regulation of proteolysis. Predicted to be located in basolateral plasma membrane; exocytic vesicle; and lateral plasma membrane. Predicted to be active in cytoplasm. Orthologous to human NKD2 (NKD inhibitor of WNT signaling pathway 2); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC308068; naked cuticle 2 homolog; naked cuticle 2 homolog (Drosophila) ; naked cuticle homolog 2; naked cuticle homolog 2 (Drosophila); NKD2, WNT signaling pathway inhibitor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,268,856 - 31,299,390 (+)NCBIGRCr8
mRatBN7.2129,442,898 - 29,470,839 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,441,328 - 29,470,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,245,109 - 29,271,956 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,244,959 - 35,271,806 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,445,737 - 29,472,584 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0132,054,390 - 32,085,416 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,058,044 - 32,084,877 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,482,721 - 33,509,561 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,252,093 - 30,278,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1130,252,483 - 30,285,229 (+)NCBI
Celera128,092,060 - 28,118,895 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
entinostat  (ISO)
FR900359  (ISO)
fucoxanthin  (ISO)
glucose  (ISO)
indometacin  (ISO)
leflunomide  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
propanal  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
rotenone  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
triadimefon  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15064403   PMID:15687260   PMID:17553928   PMID:18504258   PMID:18757723   PMID:20177058   PMID:26084600   PMID:38371458  


Genomics

Comparative Map Data
Nkd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,268,856 - 31,299,390 (+)NCBIGRCr8
mRatBN7.2129,442,898 - 29,470,839 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,441,328 - 29,470,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,245,109 - 29,271,956 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,244,959 - 35,271,806 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,445,737 - 29,472,584 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0132,054,390 - 32,085,416 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,058,044 - 32,084,877 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,482,721 - 33,509,561 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,252,093 - 30,278,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1130,252,483 - 30,285,229 (+)NCBI
Celera128,092,060 - 28,118,895 (+)NCBICelera
Cytogenetic Map1p11NCBI
NKD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3851,008,802 - 1,038,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl51,008,802 - 1,038,943 (+)EnsemblGRCh38hg38GRCh38
GRCh3751,008,917 - 1,039,058 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3651,062,168 - 1,091,925 (+)NCBINCBI36Build 36hg18NCBI36
Build 3451,062,167 - 1,091,925NCBI
Celera51,048,097 - 1,076,601 (+)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef5993,646 - 1,021,595 (+)NCBIHuRef
CHM1_151,008,923 - 1,038,814 (+)NCBICHM1_1
T2T-CHM13v2.05914,423 - 943,101 (+)NCBIT2T-CHM13v2.0
Nkd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391373,966,653 - 73,995,750 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1373,966,653 - 73,995,750 (-)EnsemblGRCm39 Ensembl
GRCm381373,818,534 - 73,847,631 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1373,818,534 - 73,847,631 (-)EnsemblGRCm38mm10GRCm38
MGSCv371373,956,776 - 73,985,079 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361374,286,135 - 74,313,614 (-)NCBIMGSCv36mm8
Celera1376,148,658 - 76,177,277 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.15NCBI
Nkd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955504507,388 - 526,407 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955504507,253 - 527,275 (+)NCBIChiLan1.0ChiLan1.0
NKD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v241,255,972 - 1,282,115 (+)NCBINHGRI_mPanPan1-v2
PanPan1.1 Ensembl51,075,172 - 1,081,664 (+)Ensemblpanpan1.1panPan2
NKD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,447,895 - 11,468,067 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,447,888 - 11,459,509 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3415,958,994 - 15,981,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03411,349,830 - 11,372,779 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3411,349,832 - 11,373,081 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13411,400,450 - 11,423,411 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,380,128 - 11,403,128 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03411,591,064 - 11,614,045 (-)NCBIUU_Cfam_GSD_1.0
Nkd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,508,104 - 244,540,117 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936815669,389 - 701,402 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936815669,389 - 701,402 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,400,997 - 79,419,759 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11679,400,323 - 79,419,779 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NKD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.14857,938 - 884,840 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl4858,809 - 884,758 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605435,414,495 - 35,441,704 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nkd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624751495,561 - 507,756 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nkd2
52 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:429
Count of miRNA genes:235
Interacting mature miRNAs:292
Transcripts:ENSRNOT00000021898
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat

Markers in Region
RH131660  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,468,562 - 29,468,749 (+)MAPPERmRatBN7.2
Rnor_6.0132,082,626 - 32,082,812NCBIRnor6.0
Rnor_5.0133,507,303 - 33,507,489UniSTSRnor5.0
RGSC_v3.4130,276,675 - 30,276,861UniSTSRGSC3.4
Celera128,116,637 - 28,116,823UniSTS
Cytogenetic Map1p11UniSTS
BE120631  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,465,623 - 29,465,773 (+)MAPPERmRatBN7.2
Rnor_6.0132,079,687 - 32,079,836NCBIRnor6.0
Rnor_5.0133,504,364 - 33,504,513UniSTSRnor5.0
RGSC_v3.4130,273,736 - 30,273,885UniSTSRGSC3.4
Celera128,113,698 - 28,113,847UniSTS
Cytogenetic Map1p11UniSTS
RH144358  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,443,748 - 29,443,919 (+)MAPPERmRatBN7.2
Rnor_6.0132,057,813 - 32,057,983NCBIRnor6.0
Rnor_5.0133,482,490 - 33,482,660UniSTSRnor5.0
RGSC_v3.4130,251,862 - 30,252,032UniSTSRGSC3.4
Celera128,091,829 - 28,091,999UniSTS
Cytogenetic Map1p11UniSTS
AU048943  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,449,300 - 29,449,432 (+)MAPPERmRatBN7.2
Rnor_6.0132,063,365 - 32,063,496NCBIRnor6.0
Rnor_5.0133,488,042 - 33,488,173UniSTSRnor5.0
RGSC_v3.4130,257,414 - 30,257,545UniSTSRGSC3.4
Celera128,097,381 - 28,097,512UniSTS
Cytogenetic Map1p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000021898   ⟹   ENSRNOP00000021898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,443,980 - 29,470,821 (+)Ensembl
Rnor_6.0 Ensembl132,058,044 - 32,084,877 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118428   ⟹   ENSRNOP00000086365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,457,842 - 29,470,821 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119209   ⟹   ENSRNOP00000086125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,441,328 - 29,470,821 (+)Ensembl
RefSeq Acc Id: NM_001107454   ⟹   NP_001100924
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,272,532 - 31,299,372 (+)NCBI
mRatBN7.2129,443,980 - 29,470,821 (+)NCBI
Rnor_6.0132,058,044 - 32,084,884 (+)NCBI
Rnor_5.0133,482,721 - 33,509,561 (+)NCBI
RGSC_v3.4130,252,093 - 30,278,933 (+)RGD
Celera128,092,060 - 28,118,895 (+)RGD
Sequence:
RefSeq Acc Id: XM_017589090   ⟹   XP_017444579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,271,715 - 31,299,390 (+)NCBI
mRatBN7.2129,443,163 - 29,470,839 (+)NCBI
Rnor_6.0132,057,153 - 32,085,416 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063288362   ⟹   XP_063144432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,268,856 - 31,299,390 (+)NCBI
RefSeq Acc Id: XM_063288366   ⟹   XP_063144436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,271,707 - 31,299,390 (+)NCBI
RefSeq Acc Id: XM_063288369   ⟹   XP_063144439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,271,715 - 31,299,390 (+)NCBI
RefSeq Acc Id: XM_063288371   ⟹   XP_063144441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,286,288 - 31,299,390 (+)NCBI
RefSeq Acc Id: NP_001100924   ⟸   NM_001107454
- UniProtKB: D4A182 (UniProtKB/TrEMBL),   A6JUW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444579   ⟸   XM_017589090
- Peptide Label: isoform X2
- UniProtKB: D4A182 (UniProtKB/TrEMBL),   A6JUW2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021898   ⟸   ENSRNOT00000021898
Ensembl Acc Id: ENSRNOP00000086365   ⟸   ENSRNOT00000118428
Ensembl Acc Id: ENSRNOP00000086125   ⟸   ENSRNOT00000119209
RefSeq Acc Id: XP_063144432   ⟸   XM_063288362
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063144436   ⟸   XM_063288366
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063144439   ⟸   XM_063288369
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A1L5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144441   ⟸   XM_063288371
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A619 (UniProtKB/TrEMBL)
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A182-F1-model_v2 AlphaFold D4A182 1-458 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689564
Promoter ID:EPDNEW_R89
Type:multiple initiation site
Name:Nkd2_1
Description:naked cuticle homolog 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0132,058,045 - 32,058,105EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311459 AgrOrtholog
BioCyc Gene G2FUF-61931 BioCyc
Ensembl Genes ENSRNOG00000016103 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021898.6 UniProtKB/TrEMBL
  ENSRNOT00000118428.1 UniProtKB/TrEMBL
  ENSRNOT00000119209.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-like_dom UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_Ca-bd UniProtKB/TrEMBL
  Nkd-like UniProtKB/TrEMBL
KEGG Report rno:308068 UniProtKB/TrEMBL
NCBI Gene 308068 ENTREZGENE
PANTHER PROTEIN NAKED CUTICLE HOMOLOG 2 UniProtKB/TrEMBL
  PTHR22611 UniProtKB/TrEMBL
PhenoGen Nkd2 PhenoGen
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016103 RatGTEx
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A8I6A1L5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A619 ENTREZGENE, UniProtKB/TrEMBL
  A6JUW2 ENTREZGENE, UniProtKB/TrEMBL
  D4A182 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-04 Nkd2  NKD inhibitor of WNT signaling pathway 2  Nkd2  NKD2, WNT signaling pathway inhibitor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-12-04 Nkd2  NKD2, WNT signaling pathway inhibitor  Nkd2  naked cuticle homolog 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-14 Nkd2  naked cuticle homolog 2  Nkd2  naked cuticle homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-20 Nkd2  naked cuticle homolog 2 (Drosophila)  Nkd2  naked cuticle 2 homolog (Drosophila)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nkd2  naked cuticle 2 homolog (Drosophila)   Nkd2_predicted  naked cuticle 2 homolog (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nkd2_predicted  naked cuticle 2 homolog (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED