Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Nkd2 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Nkd2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of NKD2 mRNA | CTD | PMID:22206623 | Nkd2 | Rat | 17beta-estradiol | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Estradiol results in increased expression of NKD2 mRNA | CTD | PMID:31614463 | Nkd2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NKD2 mRNA | CTD | PMID:20106945 more ... | Nkd2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of NKD2 mRNA | CTD | PMID:32109520 | Nkd2 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | Nkd2 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | NKD2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of NKD2 mRNA | CTD | PMID:28628672 | Nkd2 | Rat | 3-methylcholanthrene | multiple interactions | ISO | Nkd2 (Mus musculus) | 6480464 | [Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of NKD2 mRNA | CTD | PMID:23519560 | Nkd2 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Nkd2 (Mus musculus) | 6480464 | bisphenol S results in increased expression of NKD2 mRNA | CTD | PMID:30951980 | Nkd2 | Rat | 5-aza-2'-deoxycytidine | affects expression | ISO | NKD2 (Homo sapiens) | 6480464 | Decitabine affects the expression of NKD2 mRNA | CTD | PMID:23300844 | Nkd2 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of NKD2 mRNA | CTD | PMID:25825206 | Nkd2 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of NKD2 mRNA | CTD | PMID:30047161 | Nkd2 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of NKD2 mRNA | CTD | PMID:31881176 | Nkd2 | Rat | acrylamide | decreases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of NKD2 mRNA | CTD | PMID:32763439 | Nkd2 | Rat | aflatoxin B1 | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of NKD2 mRNA | CTD | PMID:21641981 and PMID:32234424 | Nkd2 | Rat | aldehydo-D-glucose | multiple interactions | ISO | Nkd2 (Mus musculus) | 6480464 | fucoxanthin inhibits the reaction [Glucose results in decreased expression of NKD2 mRNA] | CTD | PMID:33448797 | Nkd2 | Rat | aldehydo-D-glucose | decreases expression | ISO | Nkd2 (Mus musculus) | 6480464 | Glucose results in decreased expression of NKD2 mRNA | CTD | PMID:33448797 | Nkd2 | Rat | all-trans-retinoic acid | decreases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of NKD2 mRNA | CTD | PMID:33167477 | Nkd2 | Rat | alpha-Zearalanol | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of NKD2 mRNA | CTD | PMID:35163327 | Nkd2 | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of NKD2 mRNA | CTD | PMID:30047161 | Nkd2 | Rat | aristolochic acid A | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of NKD2 mRNA | CTD | PMID:33212167 | Nkd2 | Rat | arsane | affects methylation | ISO | NKD2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of NKD2 gene | CTD | PMID:25304211 | Nkd2 | Rat | arsenic atom | affects methylation | ISO | NKD2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of NKD2 gene | CTD | PMID:25304211 | Nkd2 | Rat | arsenous acid | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of NKD2 mRNA | CTD | PMID:19128835 | Nkd2 | Rat | atrazine | decreases expression | EXP | | 6480464 | Atrazine results in decreased expression of NKD2 mRNA | CTD | PMID:36841081 | Nkd2 | Rat | benzo[a]pyrene | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of NKD2 mRNA | CTD | PMID:20106945 more ... | Nkd2 | Rat | benzo[a]pyrene | increases methylation | ISO | NKD2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of NKD2 promoter | CTD | PMID:27901495 | Nkd2 | Rat | beta-lapachone | decreases expression | ISO | NKD2 (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of NKD2 mRNA | CTD | PMID:38218311 | Nkd2 | Rat | beta-lapachone | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of NKD2 mRNA | CTD | PMID:38218311 | Nkd2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of NKD2 mRNA | CTD | PMID:25181051 and PMID:34947998 | Nkd2 | Rat | bisphenol A | increases expression | ISO | Nkd2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of NKD2 mRNA | CTD | PMID:30951980 | Nkd2 | Rat | bisphenol F | increases expression | ISO | Nkd2 (Mus musculus) | 6480464 | bisphenol F results in increased expression of NKD2 mRNA | CTD | PMID:30951980 | Nkd2 | Rat | butanal | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of NKD2 mRNA | CTD | PMID:26079696 | Nkd2 | Rat | C.I. Natural Red 20 | decreases expression | ISO | NKD2 (Homo sapiens) | 6480464 | shikonin results in decreased expression of NKD2 mRNA | CTD | PMID:37268198 | Nkd2 | Rat | cadmium dichloride | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of NKD2 mRNA | CTD | PMID:38568856 | Nkd2 | Rat | calcitriol | decreases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of NKD2 mRNA | CTD | PMID:26485663 | Nkd2 | Rat | camptothecin | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Camptothecin results in increased expression of NKD2 mRNA | CTD | PMID:38460933 | Nkd2 | Rat | carbon nanotube | affects expression | ISO | Nkd2 (Mus musculus) | 6480464 | Nanotubes and Carbon affects the expression of NKD2 mRNA | CTD | PMID:25554681 | Nkd2 | Rat | carbon nanotube | increases expression | ISO | Nkd2 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in increased expression of NKD2 mRNA | CTD | PMID:25620056 | Nkd2 | Rat | carbon nanotube | decreases expression | ISO | Nkd2 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | Nkd2 | Rat | carmustine | affects response to substance | ISO | NKD2 (Homo sapiens) | 6480464 | NKD2 mRNA affects the susceptibility to Carmustine | CTD | PMID:16365179 | Nkd2 | Rat | chlordecone | decreases expression | ISO | Nkd2 (Mus musculus) | 6480464 | Chlordecone results in decreased expression of NKD2 mRNA | CTD | PMID:33711761 | Nkd2 | Rat | cisplatin | affects expression | ISO | NKD2 (Homo sapiens) | 6480464 | Cisplatin affects the expression of NKD2 mRNA | CTD | PMID:23300844 | Nkd2 | Rat | cisplatin | multiple interactions | ISO | NKD2 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of NKD2 mRNA | CTD | PMID:27392435 | Nkd2 | Rat | cisplatin | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of NKD2 mRNA | CTD | PMID:27392435 | Nkd2 | Rat | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of NKD2 mRNA | CTD | PMID:30556269 | Nkd2 | Rat | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of NKD2 mRNA | CTD | PMID:30556269 | Nkd2 | Rat | cyclosporin A | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of NKD2 mRNA | CTD | PMID:25562108 | Nkd2 | Rat | D-glucose | decreases expression | ISO | Nkd2 (Mus musculus) | 6480464 | Glucose results in decreased expression of NKD2 mRNA | CTD | PMID:33448797 | Nkd2 | Rat | D-glucose | multiple interactions | ISO | Nkd2 (Mus musculus) | 6480464 | fucoxanthin inhibits the reaction [Glucose results in decreased expression of NKD2 mRNA] | CTD | PMID:33448797 | Nkd2 | Rat | decabromodiphenyl ether | increases expression | EXP | | 6480464 | decabromobiphenyl ether results in increased expression of NKD2 mRNA | CTD | PMID:23640034 | Nkd2 | Rat | dexamethasone | multiple interactions | ISO | NKD2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of NKD2 mRNA | CTD | PMID:28628672 | Nkd2 | Rat | diarsenic trioxide | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of NKD2 mRNA | CTD | PMID:19128835 | Nkd2 | Rat | entinostat | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | entinostat results in increased expression of NKD2 mRNA | CTD | PMID:27188386 | Nkd2 | Rat | FR900359 | decreases phosphorylation | ISO | NKD2 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of NKD2 protein | CTD | PMID:37730182 | Nkd2 | Rat | fucoxanthin | multiple interactions | ISO | Nkd2 (Mus musculus) | 6480464 | fucoxanthin inhibits the reaction [Glucose results in decreased expression of NKD2 mRNA] | CTD | PMID:33448797 | Nkd2 | Rat | glucose | decreases expression | ISO | Nkd2 (Mus musculus) | 6480464 | Glucose results in decreased expression of NKD2 mRNA | CTD | PMID:33448797 | Nkd2 | Rat | glucose | multiple interactions | ISO | Nkd2 (Mus musculus) | 6480464 | fucoxanthin inhibits the reaction [Glucose results in decreased expression of NKD2 mRNA] | CTD | PMID:33448797 | Nkd2 | Rat | indometacin | multiple interactions | ISO | NKD2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of NKD2 mRNA | CTD | PMID:28628672 | Nkd2 | Rat | leflunomide | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | leflunomide results in increased expression of NKD2 mRNA | CTD | PMID:28988120 | Nkd2 | Rat | methotrexate | affects expression | ISO | Nkd2 (Mus musculus) | 6480464 | Methotrexate affects the expression of NKD2 mRNA | CTD | PMID:18502557 | Nkd2 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of NKD2 gene | CTD | PMID:35440735 | Nkd2 | Rat | N-methyl-4-phenylpyridinium | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of NKD2 mRNA | CTD | PMID:24810058 | Nkd2 | Rat | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of NKD2 mRNA | CTD | PMID:28801915 | Nkd2 | Rat | O-methyleugenol | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | methyleugenol results in increased expression of NKD2 mRNA | CTD | PMID:32234424 | Nkd2 | Rat | ozone | multiple interactions | ISO | Nkd2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of NKD2 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of NKD2 mRNA | CTD | PMID:34911549 | Nkd2 | Rat | paracetamol | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of NKD2 mRNA | CTD | PMID:29067470 | Nkd2 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of NKD2 mRNA | CTD | PMID:33387578 | Nkd2 | Rat | pentanal | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | pentanal results in increased expression of NKD2 mRNA | CTD | PMID:26079696 | Nkd2 | Rat | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of NKD2 mRNA | CTD | PMID:35163327 | Nkd2 | Rat | phorbol 13-acetate 12-myristate | multiple interactions | ISO | Nkd2 (Mus musculus) | 6480464 | [Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of NKD2 mRNA | CTD | PMID:23519560 | Nkd2 | Rat | propanal | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of NKD2 mRNA | CTD | PMID:26079696 | Nkd2 | Rat | propiconazole | decreases expression | EXP | | 6480464 | propiconazole results in decreased expression of NKD2 mRNA | CTD | PMID:30047161 | Nkd2 | Rat | quercetin | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Quercetin results in increased expression of NKD2 mRNA | CTD | PMID:21632981 | Nkd2 | Rat | rotenone | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Rotenone results in increased expression of NKD2 mRNA | CTD | PMID:29955902 | Nkd2 | Rat | Shikonin | decreases expression | ISO | NKD2 (Homo sapiens) | 6480464 | shikonin results in decreased expression of NKD2 mRNA | CTD | PMID:37268198 | Nkd2 | Rat | silicon dioxide | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of NKD2 mRNA | CTD | PMID:23806026 and PMID:25895662 | Nkd2 | Rat | silicon dioxide | decreases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Silicon Dioxide results in decreased expression of NKD2 mRNA | CTD | PMID:34973136 | Nkd2 | Rat | sodium arsenate | increases expression | ISO | Nkd2 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of NKD2 mRNA | CTD | PMID:21795629 | Nkd2 | Rat | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of NKD2 mRNA | CTD | PMID:19281266 | Nkd2 | Rat | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of NKD2 mRNA | CTD | PMID:30047161 | Nkd2 | Rat | sunitinib | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of NKD2 mRNA | CTD | PMID:31533062 | Nkd2 | Rat | temozolomide | affects response to substance | ISO | NKD2 (Homo sapiens) | 6480464 | NKD2 mRNA affects the susceptibility to temozolomide | CTD | PMID:16365179 | Nkd2 | Rat | tetrachloromethane | affects expression | ISO | Nkd2 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of NKD2 mRNA | CTD | PMID:17484886 | Nkd2 | Rat | titanium dioxide | decreases expression | ISO | Nkd2 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of NKD2 mRNA | CTD | PMID:23557971 | Nkd2 | Rat | titanium dioxide | decreases methylation | ISO | Nkd2 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of NKD2 gene | CTD | PMID:35295148 | Nkd2 | Rat | titanium dioxide | increases methylation | ISO | Nkd2 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of NKD2 gene | CTD | PMID:35295148 | Nkd2 | Rat | triadimefon | decreases expression | EXP | | 6480464 | triadimefon results in decreased expression of NKD2 mRNA | CTD | PMID:30047161 | Nkd2 | Rat | urethane | decreases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Urethane results in decreased expression of NKD2 mRNA | CTD | PMID:28818685 | Nkd2 | Rat | valproic acid | affects expression | ISO | NKD2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of NKD2 mRNA | CTD | PMID:25979313 | Nkd2 | Rat | valproic acid | increases expression | ISO | NKD2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of NKD2 mRNA | CTD | PMID:28001369 and PMID:29154799 | Nkd2 | Rat | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of NKD2 gene | CTD | PMID:31682807 | |