NKD2 (NKD inhibitor of WNT signaling pathway 2) - Rat Genome Database

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Gene: NKD2 (NKD inhibitor of WNT signaling pathway 2) Chlorocebus sabaeus
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Symbol: NKD2
Name: NKD inhibitor of WNT signaling pathway 2
RGD ID: 18749405
Description: ENCODES a protein that exhibits ATPase binding (ortholog); growth factor binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN Golgi vesicle fusion to target membrane (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); positive regulation of protein localization to plasma membrane (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant dyskeratosis congenita 2 (ortholog); dopamine transporter deficiency syndrome (ortholog); genetic disease (ortholog); FOUND IN basolateral plasma membrane (ortholog); cell periphery (ortholog); cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: naked cuticle homolog 2; NKD2, WNT signaling pathway inhibitor; protein naked cuticle homolog 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.14857,938 - 884,840 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl4858,809 - 884,758 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605435,414,495 - 35,441,704 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NKD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.14857,938 - 884,840 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl4858,809 - 884,758 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605435,414,495 - 35,441,704 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NKD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3851,008,802 - 1,038,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl51,008,802 - 1,038,943 (+)EnsemblGRCh38hg38GRCh38
GRCh3751,008,917 - 1,039,058 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3651,062,168 - 1,091,925 (+)NCBINCBI36Build 36hg18NCBI36
Build 3451,062,167 - 1,091,925NCBI
Celera51,048,097 - 1,076,601 (+)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef5993,646 - 1,021,595 (+)NCBIHuRef
CHM1_151,008,923 - 1,038,814 (+)NCBICHM1_1
T2T-CHM13v2.05914,423 - 943,101 (+)NCBIT2T-CHM13v2.0
Nkd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391373,966,653 - 73,995,750 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1373,966,653 - 73,995,750 (-)EnsemblGRCm39 Ensembl
GRCm381373,818,534 - 73,847,631 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1373,818,534 - 73,847,631 (-)EnsemblGRCm38mm10GRCm38
MGSCv371373,956,776 - 73,985,079 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361374,286,135 - 74,313,614 (-)NCBIMGSCv36mm8
Celera1376,148,658 - 76,177,277 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.15NCBI
Nkd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,268,856 - 31,299,390 (+)NCBIGRCr8
mRatBN7.2129,442,898 - 29,470,839 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,441,328 - 29,470,821 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,245,109 - 29,271,956 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,244,959 - 35,271,806 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,445,737 - 29,472,584 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0132,054,390 - 32,085,416 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,058,044 - 32,084,877 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,482,721 - 33,509,561 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,252,093 - 30,278,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1130,252,483 - 30,285,229 (+)NCBI
Celera128,092,060 - 28,118,895 (+)NCBICelera
Cytogenetic Map1p11NCBI
Nkd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955504507,388 - 526,407 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955504507,253 - 527,275 (+)NCBIChiLan1.0ChiLan1.0
NKD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,447,895 - 11,468,067 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,447,888 - 11,459,509 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3415,958,994 - 15,981,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03411,349,830 - 11,372,779 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3411,349,832 - 11,373,081 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13411,400,450 - 11,423,411 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,380,128 - 11,403,128 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03411,591,064 - 11,614,045 (-)NCBIUU_Cfam_GSD_1.0
Nkd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,508,104 - 244,540,117 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936815669,389 - 701,402 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936815669,389 - 701,402 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,400,997 - 79,419,759 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11679,400,323 - 79,419,779 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Nkd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624751495,561 - 507,756 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 36 15 60
Below cutoff 4

Sequence


RefSeq Acc Id: ENSCSAT00000015496   ⟹   ENSCSAP00000013435
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl4858,809 - 884,758 (+)Ensembl
RefSeq Acc Id: XM_007961111   ⟹   XP_007959302
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.14857,938 - 884,840 (+)NCBI
Vero_WHO_p1.0NW_02366605435,414,495 - 35,441,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007961113   ⟹   XP_007959304
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.14857,938 - 884,840 (+)NCBI
Vero_WHO_p1.0NW_02366605435,414,495 - 35,441,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007961114   ⟹   XP_007959305
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.14857,938 - 884,174 (+)NCBI
Vero_WHO_p1.0NW_02366605435,414,495 - 35,439,934 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007959302 (Get FASTA)   NCBI Sequence Viewer  
  XP_007959304 (Get FASTA)   NCBI Sequence Viewer  
  XP_007959305 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000013435.1
RefSeq Acc Id: XP_007959302   ⟸   XM_007961111
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RXU6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007959304   ⟸   XM_007961113
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RXU6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007959305   ⟸   XM_007961114
- Peptide Label: isoform X3
RefSeq Acc Id: ENSCSAP00000013435   ⟸   ENSCSAT00000015496


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017405 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015496.1 UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
NCBI Gene NKD2 ENTREZGENE
PANTHER PROTEIN NAKED CUTICLE HOMOLOG 2 UniProtKB/TrEMBL
  PTHR22611 UniProtKB/TrEMBL
PROSITE EF_HAND_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A0D9RXU6 ENTREZGENE, UniProtKB/TrEMBL