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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mTOR inhibitor
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Accession:CHEBI:68481 term browser browse the term
Definition:A protein kinase inhibitor of the mammalian target of rapamycin (mTOR), a protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis and transcription. mTOR inhibitors are used to prevent transplant rejection and in treatment of cancer.
Synonyms:related_synonym: mTOR inhibitors;   mammalian target of rapamycin inhibitor;   mammalian target of rapamycin inhibitors
 xref: Wikipedia:MTOR_inhibitors


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dactolisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases expression
increases phosphorylation
decreases phosphorylation
multiple interactions		 ISO
EXP		 dactolisib results in decreased expression of AKT1 protein modified form
dactolisib increases phosphorylation of Akt in rat tumor grafts
dactolisib results in decreased phosphorylation of AKT1 protein
dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; LEPR affects the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]
dactolisib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]		 CTD
RGD		 PMID:19435893 PMID:21464613 PMID:22415236 PMID:22949526 PMID:23151917 More... RGD:152177690 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Chloroquine promotes the reaction [dactolisib affects the folding of and results in increased activity of BAX protein]; dactolisib affects the folding of and results in increased activity of BAX protein; dactolisib promotes the reaction [Chloroquine affects the folding of and results in increased activity of BAX protein] CTD PMID:23151917 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 affects expression ISO dactolisib affects the expression of BCL2L1 protein CTD PMID:25640480 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 affects expression ISO dactolisib affects the expression of BCL2L11 protein CTD PMID:25640480 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO dactolisib results in decreased expression of BIRC5 protein CTD PMID:22729845 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage		 ISO dactolisib results in increased activity of CASP3 protein
Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP3 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]		 CTD PMID:21372221 PMID:23151917 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage		 ISO Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP9 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP9 protein] CTD PMID:23151917 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 decreases phosphorylation ISO dactolisib results in decreased phosphorylation of CCND1 protein CTD PMID:23651616 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO dactolisib results in increased expression of CDKN1A protein CTD PMID:23651616 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ctsb cathepsin B affects localization
multiple interactions		 ISO dactolisib affects the localization of CTSB protein
[Chloroquine co-treated with dactolisib] affects the localization of CTSB protein		 CTD PMID:23151917 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO dactolisib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:24758408 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions
increases response to substance		 ISO dactolisib results in decreased phosphorylation of EIF4EBP1 protein
Ku 0063794 inhibits the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein]; mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein]
EIF4EBP1 protein modified form results in increased susceptibility to dactolisib		 CTD PMID:21372221 PMID:22415236 PMID:23151917 PMID:25640480 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Hsf1 heat shock transcription factor 1 decreases activity ISO dactolisib results in decreased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of OXSR1 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of SLC12A3 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of STK39 protein] CTD PMID:22949526 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Lepr leptin receptor multiple interactions ISO LEPR affects the reaction [dactolisib results in decreased phosphorylation of AKT1 protein] CTD PMID:22949526 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases metabolic processing
affects localization		 ISO dactolisib results in increased metabolism of MAP1LC3A protein
dactolisib affects the localization of MAP1LC3A protein		 CTD PMID:23651616 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO dactolisib promotes the reaction [mirdametinib results in decreased phosphorylation of MAPK1 protein] CTD PMID:22415236 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO dactolisib promotes the reaction [mirdametinib results in decreased phosphorylation of MAPK3 protein] CTD PMID:22415236 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects expression
multiple interactions		 ISO dactolisib affects the expression of MCL1 protein
[dactolisib co-treated with (+)-JQ1 compound] affects the expression of MCL1 protein		 CTD PMID:25640480 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase increases response to substance ISO OGT mutant form results in increased susceptibility to dactolisib CTD PMID:23029544 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146 		JBrowse link
G Oxsr1 oxidative stress responsive kinase 1 multiple interactions
decreases phosphorylation		 ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of OXSR1 protein]
dactolisib results in decreased phosphorylation of OXSR1 protein		 CTD PMID:22949526 NCBI chr 8:118,972,754...119,062,102
Ensembl chr 8:118,972,754...119,062,027 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO dactolisib results in increased cleavage of PARP1 protein CTD PMID:21464613 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases response to substance
decreases response to substance		 ISO PIK3CA results in increased susceptibility to dactolisib
PIK3CA results in decreased susceptibility to dactolisib		 CTD PMID:21372221 PMID:21633166 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pten phosphatase and tensin homolog increases response to substance ISO PTEN gene mutant form results in increased susceptibility to dactolisib CTD PMID:21372221 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO dactolisib results in decreased expression of RB1 protein modified form CTD PMID:23651616 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation		 ISO mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of RPS6 protein] CTD PMID:21372221 PMID:21464613 PMID:21498705 PMID:22415236 PMID:23151917 More... NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO dactolisib results in decreased phosphorylation of RPS6KB1 protein CTD PMID:21464613 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 multiple interactions
decreases phosphorylation		 ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of SLC12A3 protein]
dactolisib results in decreased phosphorylation of SLC12A3 protein		 CTD PMID:22949526 NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression		 ISO bafilomycin A1 inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein] CTD PMID:23151917 PMID:23651616 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stk39 serine threonine kinase 39 multiple interactions
decreases phosphorylation		 ISO dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of STK39 protein]
dactolisib results in decreased phosphorylation of STK39 protein		 CTD PMID:22949526 NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060 		JBrowse link
everolimus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Everolimus results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects stability
affects response to substance
multiple interactions		 ISO ABCB1A protein affects the stability of Everolimus
ABCB1 polymorphism affects the susceptibility to Everolimus
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCB1A protein affects the stability of Everolimus]; Everolimus inhibits the reaction [ABCB1A protein affects the metabolism of irinotecan]		 CTD PMID:24727322 PMID:27169792 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects stability
multiple interactions		 ISO ABCB1B protein affects the stability of Everolimus
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCB1B protein affects the stability of Everolimus]; Everolimus inhibits the reaction [ABCB1B protein affects the metabolism of irinotecan]		 CTD PMID:24727322 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects stability
multiple interactions		 ISO ABCG2 protein affects the stability of Everolimus
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCG2 protein affects the stability of Everolimus]; Everolimus inhibits the reaction [ABCG2 protein affects the metabolism of irinotecan]		 CTD PMID:24727322 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
decreases phosphorylation		 ISO
EXP		 Everolimus results in increased phosphorylation of AKT1 protein
Everolimus inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]; MK 2206 inhibits the reaction [Everolimus inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]]
Everolimus results in decreased phosphorylation of AKT1 protein		 CTD PMID:16033851 PMID:22885370 PMID:23300809 PMID:28711525 PMID:37739323 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 increases phosphorylation
multiple interactions		 ISO
EXP		 Everolimus results in increased phosphorylation of AKT2 protein
Everolimus inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT2 protein]; MK 2206 inhibits the reaction [Everolimus inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT2 protein]]		 CTD PMID:37739323 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 multiple interactions
increases phosphorylation		 EXP
ISO		 Everolimus inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT3 protein]; MK 2206 inhibits the reaction [Everolimus inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT3 protein]]
Everolimus results in increased phosphorylation of AKT3 protein		 CTD PMID:37739323 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Everolimus inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:37739323 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Everolimus inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:37739323 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions		 ISO Everolimus results in decreased expression of BIRC5 protein
Everolimus promotes the reaction [platycodin D results in decreased expression of BIRC5 protein]; navitoclax promotes the reaction [Everolimus results in decreased expression of BIRC5 protein]; platycodin D promotes the reaction [Everolimus results in decreased expression of BIRC5 protein]		 CTD PMID:21601561 PMID:28711525 PMID:28947240 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Brd4 bromodomain containing 4 multiple interactions ISO [MYC protein results in decreased susceptibility to Everolimus] promotes the reaction [BRD4 protein binds to MYC gene] CTD PMID:25537515 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO Everolimus results in increased cleavage of CASP3 protein CTD PMID:15940265 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Everolimus results in decreased expression of CCNA2 protein CTD PMID:16856892 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO Everolimus results in decreased expression of CCND1 protein
[letrozole co-treated with Everolimus] results in decreased expression of CCND1 protein		 CTD PMID:16033851 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression		 ISO [letrozole co-treated with Everolimus] results in decreased expression of CCND2 protein
Everolimus results in decreased expression of CCND2 protein		 CTD PMID:16033851 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Everolimus results in decreased expression of CCND3 protein CTD PMID:16856892 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO Everolimus results in increased expression of CDH1 protein CTD PMID:28258630 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Ces1d carboxylesterase 1D decreases activity ISO Everolimus results in decreased activity of CES1 protein CTD PMID:24727322 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Everolimus results in decreased activity of CES2 protein CTD PMID:24727322 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Everolimus inhibits the reaction [Doxorubicin results in increased expression of CYCS protein] CTD PMID:37739323 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Egfr epidermal growth factor receptor increases expression
multiple interactions		 ISO Everolimus results in increased expression of EGFR mRNA; Everolimus results in increased expression of EGFR protein
platycodin D inhibits the reaction [Everolimus results in increased expression of EGFR protein]		 CTD PMID:28711525 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation
multiple interactions		 ISO Everolimus results in increased phosphorylation of EIF4E protein
Everolimus inhibits the reaction [Estradiol results in decreased phosphorylation of EIF4E protein]		 CTD PMID:16033851 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases phosphorylation		 ISO [letrozole co-treated with Everolimus] results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein; Everolimus inhibits the reaction [Estradiol results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein]; Everolimus promotes the reaction [platycodin D results in decreased phosphorylation of EIF4EBP1 protein]; Everolimus results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein; platycodin D promotes the reaction [Everolimus results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:16033851 PMID:16856892 PMID:16951235 PMID:21372221 PMID:28711525 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma 1 multiple interactions ISO Everolimus inhibits the reaction [Estradiol results in increased phosphorylation of EIF4G1 protein] CTD PMID:16033851 NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Everolimus promotes the reaction [TNF protein results in increased expression of F3 protein] CTD PMID:19567381 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
increases expression		 ISO platycodin D inhibits the reaction [Everolimus results in increased expression of IGF1R protein]
Everolimus results in increased expression of IGF1R mRNA; Everolimus results in increased expression of IGF1R protein		 CTD PMID:28711525 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Everolimus promotes the reaction [Tretinoin results in increased expression of ITGAM protein] CTD PMID:29743969 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases lipidation EXP Everolimus results in increased lipidation of MAP1LC3A protein CTD PMID:37739323 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Everolimus promotes the reaction [N-((1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl)octanamide results in increased expression of and results in increased lipidation of MAP1LC3B protein] CTD PMID:32397857 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Everolimus inhibits the reaction [4-cresol results in increased expression of MMP9 protein] CTD PMID:30910523 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
decreases activity		 ISO
EXP		 [Everolimus co-treated with Y 27632] inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein]; [Letrozole co-treated with Everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Everolimus inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein]; Everolimus inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Everolimus inhibits the reaction [Estradiol affects the activity of MTOR protein]; Everolimus inhibits the reaction [MTOR results in decreased susceptibility to Trabectedin]
Everolimus results in decreased phosphorylation of MTOR protein
Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein]]
Everolimus results in decreased activity of MTOR; Everolimus results in decreased activity of MTOR protein		 CTD PMID:16033851 PMID:20890178 PMID:21622721 PMID:24989011 PMID:30910523 More... NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases response to substance
increases expression		 ISO [MYC protein results in decreased susceptibility to Everolimus] promotes the reaction [BRD4 protein binds to MYC gene]
Everolimus results in increased expression of MYC protein		 CTD PMID:25537515 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein]]; Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of RPS6KB1 protein]] CTD PMID:24989011 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression		 ISO Aspirin inhibits the reaction [Everolimus results in decreased expression of NOS3 protein]; cilostazol inhibits the reaction [Everolimus results in decreased expression of NOS3 protein] CTD PMID:19520256 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases activity ISO Everolimus results in decreased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [navitoclax co-treated with Everolimus] results in increased cleavage of PARP1 protein CTD PMID:28947240 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Everolimus results in increased expression of PTGS2 mRNA; Everolimus results in increased expression of PTGS2 protein CTD PMID:15937522 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression ISO Everolimus results in decreased expression of PTK2 protein modified form CTD PMID:28258630 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases phosphorylation		 ISO [letrozole co-treated with Everolimus] results in decreased phosphorylation of and affects the activity of RB1 protein; Everolimus results in decreased phosphorylation of and affects the activity of RB1 protein
Everolimus results in decreased phosphorylation of RB1 protein		 CTD PMID:16033851 PMID:16856892 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rhoa ras homolog family member A decreases expression
multiple interactions		 ISO Everolimus results in decreased expression of RHOA protein
[Everolimus co-treated with Y 27632] inhibits the reaction [4-cresol results in increased expression of RHOA protein]		 CTD PMID:28258630 PMID:30910523 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation		 ISO [letrozole co-treated with Everolimus] results in decreased phosphorylation of RPS6 protein; Everolimus inhibits the reaction [Estradiol results in increased phosphorylation of RPS6 protein]
Everolimus results in decreased phosphorylation of RPS6 protein		 CTD PMID:16033851 PMID:21372221 PMID:22885370 PMID:23151917 PMID:23300809 More... NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP
ISO		 Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of RPS6KB1 protein]]
Everolimus inhibits the reaction [Estradiol results in increased phosphorylation of RPS6KB1 protein]; Everolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]		 CTD PMID:16033851 PMID:19567381 PMID:24989011 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression		 ISO Aspirin inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein]; cilostazol inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein] CTD PMID:19520256 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases expression ISO Everolimus results in decreased expression of SRC protein modified form CTD PMID:28258630 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Everolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]; Everolimus promotes the reaction [TNF protein results in increased expression of F3 protein] CTD PMID:19567381 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vim vimentin decreases expression ISO Everolimus results in decreased expression of VIM protein CTD PMID:28258630 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Ku-0063794 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Ku 0063794 results in decreased phosphorylation of AKT1 protein CTD PMID:22885370 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Ku 0063794 co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in decreased phosphorylation of EIF4EBP1 protein; [Ku 0063794 co-treated with AZD 6244] results in decreased phosphorylation of EIF4EBP1 protein; [Ku 0063794 co-treated with mirdametinib] results in decreased phosphorylation of EIF4EBP1 protein; Ku 0063794 inhibits the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:22415236 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation		 ISO [Ku 0063794 co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in decreased phosphorylation of RPS6 protein
Ku 0063794 results in decreased phosphorylation of RPS6 protein		 CTD PMID:22415236 PMID:22885370 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
omipalisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO [omipalisib co-treated with trametinib] results in decreased phosphorylation of AKT1 protein
omipalisib results in decreased phosphorylation of AKT1 protein		 CTD PMID:22733540 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions ISO [trametinib co-treated with omipalisib] results in increased expression of BCL2L11 protein CTD PMID:22733540 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO omipalisib inhibits the reaction [RHPN1-AS1 protein results in decreased expression of BECN1 protein] CTD PMID:36125241 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP3 protein; omipalisib inhibits the reaction [RHPN1-AS1 protein results in decreased expression of CASP3 protein modified form] CTD PMID:22733540 PMID:36125241 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP7 protein CTD PMID:22733540 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 multiple interactions ISO omipalisib enhances the reaction [DDR1-IN-1 inhibits the reaction [collagen increases DDR1 autophosphorylation in human cell lines]] RGD PMID:23899692 RGD:152995467 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO omipalisib inhibits the reaction [RHPN1-AS1 protein results in increased expression of EGFR protein] CTD PMID:36125241 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO omipalisib results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:22733540 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Gnaq G protein subunit alpha q multiple interactions ISO [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP3 protein; [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP7 protein; GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib] CTD PMID:22733540 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [omipalisib co-treated with trametinib] results in increased phosphorylation of JUN protein; JUN results in decreased susceptibility to [omipalisib co-treated with trametinib] CTD PMID:22733540 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO [omipalisib co-treated with trametinib] results in decreased phosphorylation of MAPK1 protein
omipalisib results in increased phosphorylation of MAPK1 protein		 CTD PMID:22733540 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO [omipalisib co-treated with trametinib] results in decreased phosphorylation of MAPK3 protein
omipalisib results in increased phosphorylation of MAPK3 protein		 CTD PMID:22733540 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO omipalisib inhibits the reaction [RHPN1-AS1 protein results in increased phosphorylation of MTOR protein] CTD PMID:36125241 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases phosphorylation
increases cleavage		 ISO omipalisib results in decreased phosphorylation of PARP1 protein
omipalisib results in increased cleavage of PARP1 protein		 CTD PMID:21464613 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO omipalisib results in decreased phosphorylation of RPS6 protein CTD PMID:21464613 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO omipalisib results in decreased phosphorylation of RPS6KB1 protein CTD PMID:21464613 PMID:22733540 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
ridaforolimus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO ridaforolimus inhibits the reaction [Radon results in increased expression of ACTA2 protein] CTD PMID:32949624 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ridaforolimus inhibits the reaction [Radon results in decreased expression of CDH1 protein] CTD PMID:32949624 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO ridaforolimus inhibits the reaction [Radon results in increased expression of CDH2 protein] CTD PMID:32949624 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO ridaforolimus inhibits the reaction [Radon results in increased expression of FN1 protein] CTD PMID:32949624 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases activity		 ISO ridaforolimus inhibits the reaction [Radon results in increased expression of MTOR protein modified form]
ridaforolimus results in decreased activity of MTOR protein		 CTD PMID:32949624 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO ridaforolimus inhibits the reaction [Radon results in increased expression of SNAI1 protein] CTD PMID:32949624 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Vim vimentin multiple interactions ISO ridaforolimus inhibits the reaction [Radon results in increased expression of VIM protein] CTD PMID:32949624 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
sapanisertib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO sapanisertib results in decreased phosphorylation of AKT1 protein CTD PMID:26536665 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO sapanisertib results in increased expression of BCL2L11 mRNA; sapanisertib results in increased expression of BCL2L11 protein CTD PMID:26536665 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO sapanisertib results in increased cleavage of CASP3 protein CTD PMID:26536665 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO sapanisertib results in increased cleavage of CASP7 protein CTD PMID:26536665 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO sapanisertib results in decreased expression of CCND1 protein CTD PMID:26536665 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO sapanisertib results in increased expression of CDKN1B protein CTD PMID:26536665 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO sapanisertib results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:26536665 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Foxo3 forkhead box O3 affects localization ISO sapanisertib affects the localization of FOXO3 protein CTD PMID:26536665 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO sapanisertib results in increased phosphorylation of MAPK1 protein CTD PMID:29384525 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO sapanisertib results in increased phosphorylation of MAPK3 protein CTD PMID:29384525 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression
increases cleavage		 ISO sapanisertib results in decreased expression of MKI67 protein
sapanisertib results in increased cleavage of MKI67 protein		 CTD PMID:26536665 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO sapanisertib results in decreased phosphorylation of MTOR protein CTD PMID:26536665 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO sapanisertib results in decreased expression of MYC protein CTD PMID:26536665 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO sapanisertib results in increased cleavage of PARP1 protein CTD PMID:26536665 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rps6 ribosomal protein S6 decreases expression ISO sapanisertib results in decreased expression of RPS6 protein modified form CTD PMID:29384525 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO sapanisertib results in decreased phosphorylation of RPS6KB1 protein CTD PMID:26536665 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
sirolimus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP Sirolimus results in increased expression of A2M mRNA CTD PMID:21865292 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression		 ISO
EXP		 [Sirolimus co-treated with Cyclosporine] results in decreased expression of ABCA1 protein; [Sirolimus co-treated with Tacrolimus] results in increased expression of ABCA1 protein
Sirolimus results in increased expression of ABCA1 mRNA		 CTD PMID:17016853 PMID:21865292 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects metabolic processing
affects transport		 ISO ABCB1 protein affects the metabolism of Sirolimus
ABCB1 protein affects the transport of Sirolimus		 CTD PMID:15707415 PMID:15760093 PMID:15964407 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP Sirolimus results in decreased expression of ABCC2 mRNA CTD PMID:11589784 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 decreases expression EXP Sirolimus results in decreased expression of ABCC8 mRNA CTD PMID:21865292 NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 decreases expression ISO Sirolimus results in decreased expression of ABCD3 protein CTD PMID:36214828 NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020 		JBrowse link
G Abtb3 ankyrin repeat and BTB domain containing 3 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of ABTB3 mRNA] CTD PMID:21245298 NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:18,036,083...18,310,834 		JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain multiple interactions EXP Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADL mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADL mRNA]] CTD PMID:25045214 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions EXP Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADM mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADM mRNA]] CTD PMID:25045214 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression EXP Sirolimus results in decreased expression of ACE2 mRNA CTD PMID:21865292 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acer2 alkaline ceramidase 2 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in decreased expression of ACER2 mRNA] CTD PMID:21245298 NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO [Sirolimus co-treated with IGF1 protein] results in increased expression of ACTA2 protein
Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]		 CTD PMID:17908691 PMID:35405287 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actb actin, beta increases expression
multiple interactions		 ISO Sirolimus results in increased expression of ACTB mRNA
[Sirolimus binds to FKBP1A protein] which results in increased expression of ACTB mRNA		 CTD PMID:7503980 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Agt angiotensinogen multiple interactions EXP Sirolimus inhibits the reaction [AGT protein affects the localization of Calcium] CTD PMID:21613610 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases expression
multiple interactions		 EXP
ISO		 Sirolimus results in decreased expression of AIFM1 protein
[7-hydroxystaurosporine co-treated with Sirolimus] affects the localization of AIFM1 protein; Boc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] affects the localization of AIFM1 protein]		 CTD PMID:15767555 PMID:16497721 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
affects phosphorylation
increases phosphorylation		 ISO
EXP		 [Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of BCL2L11 protein; [Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of CDKN1B protein; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [Sirolimus co-treated with Arsenic Trioxide] results in decreased phosphorylation of AKT1 protein; Arsenic Trioxide inhibits the reaction [Sirolimus results in increased phosphorylation of AKT1 protein]; Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]; Cisplatin inhibits the reaction [Sirolimus results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Sirolimus results in increased phosphorylation of AKT1 protein]; Sirolimus affects the reaction [SLC31A1 protein affects the phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]
Rapamycin decreases phosphorylation of Akt1 protein in the aorta
Sirolimus affects the phosphorylation of AKT1 protein
resveratrol inhibits the reaction [Sirolimus results in increased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]
[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein; Sirolimus results in increased phosphorylation of AKT1 protein
Sirolimus results in decreased phosphorylation of AKT1 protein
[Sirolimus co-treated with Resveratrol] promotes the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [AKT1 protein mutant form results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [Pasteurella multocida toxin results in increased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [TSC1 gene mutant form results in decreased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1 protein]		 CTD
RGD		 PMID:15806154 PMID:18495876 PMID:18622747 PMID:19176369 PMID:21092744 More... RGD:408364952 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt1s1 AKT1 substrate 1 multiple interactions ISO
EXP		 [Sirolimus co-treated with resveratrol] results in decreased phosphorylation of AKT1S1 protein; resveratrol inhibits the reaction [Sirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1S1 protein]]; Sirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1S1 protein]
[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of AKT1S1 protein		 CTD PMID:24304514 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO [Sirolimus results in increased activity of AKT2 protein] which results in increased expression of CALD1 protein; [Sirolimus results in increased activity of AKT2 protein] which results in increased expression of MYH11 protein; Sirolimus results in increased phosphorylation of and results in increased activity of AKT2 protein CTD PMID:17908691 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Sirolimus inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of ALPL mRNA]] CTD PMID:33450223 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Angptl6 angiopoietin-like 6 increases expression EXP Sirolimus results in increased expression of ANGPTL6 mRNA CTD PMID:21865292 NCBI chr 8:19,413,617...19,419,925
Ensembl chr 8:19,413,619...19,419,925 		JBrowse link
G Aopep aminopeptidase O multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of AOPEP mRNA] CTD PMID:21245298 NCBI chr17:1,811,281...2,127,316
Ensembl chr17:1,811,980...2,127,331 		JBrowse link
G Apod apolipoprotein D affects localization ISO Sirolimus affects the localization of APOD protein CTD PMID:28182653 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305 		JBrowse link
G App amyloid beta precursor protein decreases expression
increases expression		 ISO Sirolimus results in decreased expression of APP protein modified form
Sirolimus results in increased expression of APP protein modified form		 CTD PMID:20542014 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Aqp2 aquaporin 2 multiple interactions
decreases expression		 EXP rosiglitazone inhibits the reaction [Sirolimus results in decreased expression of AQP2 protein] CTD PMID:19656910 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468 		JBrowse link
G Ar androgen receptor multiple interactions
increases expression
increases activity		 ISO [Sirolimus results in decreased activity of [MTOR protein binds to RPTOR protein]] which results in increased activity of AR protein; bicalutamide inhibits the reaction [Sirolimus results in increased activity of AR protein]; RPTOR protein inhibits the reaction [Sirolimus results in increased activity of AR protein]; Sirolimus affects the reaction [Testosterone results in increased expression of AR protein]; Sirolimus promotes the reaction [Dihydrotestosterone affects the expression of AR protein]
Sirolimus results in increased expression of AR protein		 CTD PMID:18776922 PMID:21036700 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) multiple interactions ISO Sirolimus inhibits the reaction [IL2 protein results in increased expression of ASNS mRNA] CTD PMID:11355896 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions ISO [(+)-JQ1 compound co-treated with Sirolimus] affects the expression of ATF3 mRNA CTD PMID:25307878 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO
EXP		 Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]
Sirolimus inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein]		 CTD PMID:24057571 PMID:29870746 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO [Sirolimus co-treated with hydroquinone] results in decreased expression of ATF6 protein CTD PMID:37148176 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atg4a autophagy related 4A, cysteine peptidase increases expression ISO Sirolimus results in increased expression of ATG4A mRNA CTD PMID:21681844 NCBI chr  X:104,665,345...104,765,271
Ensembl chr  X:104,665,345...104,765,268 		JBrowse link
G Atg4b autophagy related 4B, cysteine peptidase increases expression
multiple interactions		 ISO Sirolimus results in increased expression of ATG4B mRNA
Sirolimus inhibits the reaction [ATG4B protein results in increased expression of HK2 protein]; Sirolimus inhibits the reaction [ATG4B protein results in increased expression of LDHA protein]; Sirolimus inhibits the reaction [ATG4B protein results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [ATG4B protein results in increased expression of SLC2A1 protein]		 CTD PMID:21681844 PMID:36336208 NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103 		JBrowse link
G Atg5 autophagy related 5 multiple interactions
increases expression		 ISO
EXP		 [Sirolimus co-treated with TNF protein] results in increased expression of ATG5 mRNA; ATG5 protein affects the reaction [Sirolimus inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]]; Sirolimus inhibits the reaction [Resveratrol inhibits the reaction [Particulate Matter results in increased expression of ATG5 protein]]
Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in increased expression of ATG5 protein]]
Sirolimus results in increased expression of ATG5 protein
Sirolimus results in increased expression of ATG5 mRNA; Sirolimus results in increased expression of ATG5 protein
[Sirolimus co-treated with cadmium acetate] results in increased expression of ATG5 mRNA; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of ATG5 protein]; Sirolimus inhibits the reaction [Epirubicin results in decreased expression of ATG5 protein]; Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in increased expression of ATG5 protein]]; Sirolimus promotes the reaction [Lipopolysaccharides results in increased expression of ATG5 protein]; Sirolimus promotes the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]		 CTD PMID:19682553 PMID:29128638 PMID:29505745 PMID:29781141 PMID:29870746 More... NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO [Sirolimus co-treated with TNF protein] results in increased expression of ATG7 mRNA CTD PMID:31676321 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Aurkb aurora kinase B multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of AURKB mRNA CTD PMID:19016759 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Sirolimus inhibits the reaction [IL2 protein results in increased expression of BAD mRNA] CTD PMID:11355896 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
increases expression
multiple interactions		 ISO Sirolimus affects the localization of BAX protein
Sirolimus results in increased expression of BAX mRNA; Sirolimus results in increased expression of BAX protein
[Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BAX mRNA; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BAX protein; Sirolimus inhibits the reaction [Particulate Matter results in increased expression of BAX protein]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; Sirolimus inhibits the reaction [sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; Sirolimus inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]
[Curcumin co-treated with Sirolimus] results in increased expression of BAX; Sirolimus affects the reaction [SLC31A1 protein affects the expression of BAX protein]; Sirolimus inhibits the reaction [rebamipide results in decreased expression of BAX protein]; Sirolimus promotes the reaction [hydroquinone results in increased expression of BAX protein]		 CTD PMID:11602639 PMID:15782132 PMID:19373661 PMID:19922502 PMID:29054700 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of BBC3 protein; Sirolimus promotes the reaction [TP53 protein results in increased expression of BBC3 protein] CTD PMID:19560264 PMID:20686837 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects expression
decreases expression		 ISO
EXP		 [Curcumin co-treated with Sirolimus] results in decreased expression of BCL2; Sirolimus affects the reaction [SLC31A1 protein affects the expression of BCL2 protein]; Sirolimus inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; Sirolimus inhibits the reaction [Doxorubicin results in increased expression of BCL2 protein]; Sirolimus inhibits the reaction [rebamipide results in increased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Ethanol results in increased expression of BCL2 protein]
Sirolimus affects the expression of BCL2 protein
Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of BCL2 protein]; Sirolimus inhibits the reaction [lactacystin results in decreased expression of BCL2 protein]; Sirolimus inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]
[Sirolimus co-treated with IL2 protein] results in increased expression of BCL2 mRNA; Sirolimus inhibits the reaction [Particulate Matter results in decreased expression of BCL2 protein]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; Sirolimus inhibits the reaction [sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]
Sirolimus results in decreased expression of BCL2 mRNA; Sirolimus results in decreased expression of BCL2 protein		 CTD PMID:11355896 PMID:15571967 PMID:18640276 PMID:19373661 PMID:19764996 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
decreases expression		 ISO [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of BCL2L1 protein; Sirolimus inhibits the reaction [Colistin results in decreased expression of BCL2L1 protein]; Sirolimus inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]; Sirolimus inhibits the reaction [rebamipide results in increased expression of BCL2L1 protein]
Sirolimus results in increased expression of BCL2L1 mRNA; Sirolimus results in increased expression of BCL2L1 protein
Sirolimus results in decreased expression of BCL2L1 mRNA; Sirolimus results in decreased expression of BCL2L1 protein
[Sirolimus co-treated with IL2 protein] results in increased expression of BCL2L1 mRNA; Sirolimus inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]		 CTD PMID:11355896 PMID:15767555 PMID:15782132 PMID:18097008 PMID:18789402 More... NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions
decreases expression
increases expression		 ISO [Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of BCL2L11 protein; Sirolimus inhibits the reaction [rebamipide results in decreased expression of BCL2L11 protein]; Sirolimus promotes the reaction [Cisplatin results in increased expression of BCL2L11 mRNA]
Sirolimus results in decreased expression of BCL2L11 protein
Sirolimus results in increased expression of BCL2L11 protein		 CTD PMID:18097008 PMID:21092744 PMID:29054700 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO Sirolimus inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]; Sirolimus inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]; Sirolimus inhibits the reaction [Creatine results in increased expression of BDNF protein]; Sirolimus inhibits the reaction [Ketamine results in increased expression of BDNF protein] CTD PMID:17209049 PMID:33022268 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 ISO
EXP		 [Sirolimus co-treated with TNF protein] results in increased expression of BECN1 protein; Sirolimus inhibits the reaction [Ethanol results in increased degradation of BECN1 protein]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of BECN1 protein]; Sirolimus promotes the reaction [2,4,4'-trichlorobiphenyl results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [Caffeine results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BECN1 protein]
Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of BECN1 protein]; Sirolimus inhibits the reaction [phenanthrene results in decreased expression of BECN1 mRNA]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased expression of BECN1 protein]]; Sirolimus promotes the reaction [Trichloroethylene results in increased expression of BECN1 protein]
[Sirolimus co-treated with cadmium acetate] results in increased expression of BECN1 mRNA; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of BECN1 protein]; Sirolimus inhibits the reaction [Epirubicin results in decreased expression of BECN1 protein]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased expression of BECN1 protein]]; Sirolimus promotes the reaction [2,4,4'-trichlorobiphenyl results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [T-2 Toxin results in increased expression of BECN1 mRNA]
Sirolimus results in increased expression of BECN1 protein
Sirolimus results in increased expression of BECN1 mRNA; Sirolimus results in increased expression of BECN1 protein		 CTD PMID:20358864 PMID:21410490 PMID:26648565 PMID:26825372 PMID:27107786 More... NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO Sirolimus inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA]
Sirolimus inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of BGLAP mRNA]]		 CTD PMID:23111315 PMID:33450223 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases expression
decreases expression		 ISO [7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of BID protein
Sirolimus results in increased expression of BID mRNA; Sirolimus results in increased expression of BID protein
Sirolimus results in decreased expression of BID protein
[Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BID mRNA; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BID protein		 CTD PMID:15767555 PMID:18097008 PMID:19922502 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions
increases expression
affects localization		 ISO
EXP		 Sirolimus inhibits the reaction [Doxorubicin results in increased expression of BIRC2 protein]
Sirolimus results in increased expression of BIRC2 protein
Sirolimus affects the localization of BIRC2 protein		 CTD PMID:15571967 PMID:21357504 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression		 ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of BIRC5 mRNA; Sirolimus inhibits the reaction [N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide results in increased expression of and affects the localization of BIRC5 protein]; Sirolimus promotes the reaction [Tamoxifen results in decreased expression of BIRC5 protein]
Sirolimus results in decreased expression of BIRC5 protein		 CTD PMID:19016759 PMID:19931998 PMID:21601561 PMID:24444656 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO Sirolimus inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 mRNA] CTD PMID:23111315 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO Sirolimus inhibits the reaction [IL2 protein results in increased expression of BNIP3 mRNA] CTD PMID:11355896 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Btc betacellulin multiple interactions EXP Sirolimus inhibits the reaction [BTC protein affects the localization of CDKN1A protein]; Sirolimus inhibits the reaction [BTC protein affects the localization of CDKN1B protein]; Sirolimus inhibits the reaction [BTC protein results in increased expression of CCND1 protein] CTD PMID:19105244 NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049 		JBrowse link
G Btk Bruton tyrosine kinase multiple interactions ISO Sirolimus inhibits the reaction [IL2 protein results in increased expression of BTK mRNA] CTD PMID:11355896 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of BUB1 mRNA CTD PMID:19016759 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of BUB1B mRNA CTD PMID:19016759 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547 		JBrowse link
G C1qa complement C1q A chain decreases expression EXP Sirolimus results in decreased expression of C1QA mRNA CTD PMID:21865292 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qc complement C1q C chain decreases expression EXP Sirolimus results in decreased expression of C1QC mRNA CTD PMID:21865292 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G C3 complement C3 decreases expression EXP Sirolimus results in decreased expression of C3 mRNA CTD PMID:21865292 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cald1 caldesmon 1 multiple interactions
increases expression		 ISO [Sirolimus co-treated with IGF1 protein] results in increased expression of CALD1 protein; [Sirolimus results in increased activity of AKT2 protein] which results in increased expression of CALD1 protein
Sirolimus results in increased expression of CALD1 protein		 CTD PMID:17908691 NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein] CTD PMID:21933187 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Capn1 calpain 1 decreases activity EXP Sirolimus results in decreased activity of CAPN1 protein CTD PMID:21357504 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO
EXP		 Sirolimus inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]
Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased cleavage of CASP1 protein]; Sirolimus inhibits the reaction [Particulate Matter results in increased expression of CASP1 protein]; Sirolimus inhibits the reaction [Trichloroethylene results in increased expression of CASP1 mRNA]
Sirolimus inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]; Sirolimus inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP1 protein]		 CTD PMID:30205151 PMID:31586597 PMID:35405287 PMID:36849104 PMID:37654027 More... NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 decreases cleavage
multiple interactions		 ISO
EXP		 Sirolimus results in decreased cleavage of CASP12 protein
Sirolimus inhibits the reaction [cadmium acetate results in increased expression of CASP12 protein]		 CTD PMID:20511674 PMID:29870746 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp2 caspase 2 multiple interactions ISO [Boc-D-FMK co-treated with Sirolimus] results in increased cleavage of CASP2 protein; Boc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP2 protein] CTD PMID:15767555 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
decreases activity
increases activity
increases cleavage		 ISO
EXP		 [7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of CASP3 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP3 protein; [S 1 (combination) co-treated with Sirolimus] results in increased expression of CASP3 protein; [Sirolimus co-treated with Paclitaxel] results in increased cleavage of CASP3 protein; Boc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP3 protein]; Fluorouracil promotes the reaction [Sirolimus results in increased expression of CASP3 mRNA]; MCL1 protein inhibits the reaction [Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [Colistin results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]; Sirolimus promotes the reaction [Fluorouracil results in increased expression of CASP3 mRNA]
Sirolimus results in increased expression of CASP3 protein modified form
Sirolimus inhibits the reaction [[Rotenone co-treated with Particulate Matter] results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [gelsenicine results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [Particulate Matter results in increased expression of CASP3 protein]; Sirolimus inhibits the reaction [TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]]; Sirolimus inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Alpha-Amanitin results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Cadmium results in increased cleavage of CASP3 protein]
Sirolimus results in decreased activity of CASP3 protein
[Sirolimus co-treated with Resveratrol] results in increased cleavage of CASP3 protein; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [decamethrin results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [morroniside inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; Sirolimus inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form]; Sirolimus promotes the reaction [decamethrin results in increased cleavage of CASP3 protein]; Sirolimus results in decreased cleavage of and results in decreased activity of CASP3 protein
Sirolimus results in increased expression of CASP3 mRNA; Sirolimus results in increased expression of CASP3 protein
Sirolimus results in increased activity of CASP3 protein
Sirolimus results in increased cleavage of CASP3 protein		 CTD PMID:14502240 PMID:15571967 PMID:15753396 PMID:15767555 PMID:15782132 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
decreases activity		 ISO
EXP		 [Curcumin co-treated with Sirolimus] results in increased activity of CASP7 protein; [Sirolimus co-treated with Paclitaxel] results in increased cleavage of CASP7 protein
Sirolimus results in decreased activity of CASP7 protein		 CTD PMID:15753396 PMID:19373661 PMID:20031680 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage		 ISO [7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of CASP8 protein; [tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP8 protein; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein]; Sirolimus promotes the reaction [Cisplatin results in increased cleavage of CASP8 protein]
Sirolimus inhibits the reaction [TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein]]
Sirolimus results in increased cleavage of CASP8 protein		 CTD PMID:15767555 PMID:17121904 PMID:18058806 PMID:25307878 PMID:28342888 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
decreases activity		 ISO
EXP		 [7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP9 protein; [Sirolimus co-treated with Cisplatin] results in increased activity of CASP9 protein; [Sirolimus co-treated with Paclitaxel] results in increased cleavage of CASP9 protein; [tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP9 protein; Sirolimus inhibits the reaction [Colistin results in increased activity of CASP9 protein]; Sirolimus promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein]
Sirolimus inhibits the reaction [TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]]
[Swainsonine co-treated with Sirolimus] results in increased cleavage of CASP9 protein; Sirolimus inhibits the reaction [Staurosporine results in increased cleavage of CASP9 protein]
Sirolimus results in decreased activity of CASP9 protein		 CTD PMID:15753396 PMID:15767555 PMID:16497721 PMID:17121904 PMID:18058806 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases expression ISO Sirolimus results in increased expression of CAT protein CTD PMID:30905858 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cav3 caveolin 3 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of CAV3 mRNA] CTD PMID:21245298 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP Sirolimus results in increased expression of CCN2 mRNA CTD PMID:21865292 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression		 ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of CCNA2 mRNA
Sirolimus results in decreased expression of CCNA2 protein
Sirolimus results in decreased expression of CCNA2; Sirolimus results in decreased expression of CCNA2 protein		 CTD PMID:7503980 PMID:8419408 PMID:19016759 PMID:19505958 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb2 cyclin B2 multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of CCNB2 mRNA CTD PMID:19016759 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
increases expression
increases degradation		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]; [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with Sirolimus] results in decreased expression of CCND1; [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]; [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CCND1 protein; [Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]; [SB 216763 results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]; [Sirolimus co-treated with Letrozole] results in decreased expression of CCND1 protein; [Sirolimus co-treated with tanespimycin] results in decreased expression of CCND1 protein; [Sirolimus results in increased activity of GSK3B protein] which results in increased phosphorylation of and results in increased degradation of CCND1 protein; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]
Sirolimus inhibits the reaction [BTC protein results in increased expression of CCND1 protein]; Sirolimus inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]
Sirolimus results in increased degradation of CCND1 protein		 CTD PMID:7532117 PMID:15753396 PMID:15767555 PMID:17121904 PMID:19105244 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression		 ISO
EXP		 [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of CCND2 mRNA]
Sirolimus results in decreased expression of CCND2 protein
Sirolimus inhibits the reaction [FSHB protein results in increased expression of CCND2 mRNA]		 CTD PMID:15070696 PMID:15778701 PMID:17510244 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 multiple interactions
decreases expression
decreases stability		 ISO [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of CCND3 mRNA]
Sirolimus results in decreased expression of CCND3 mRNA; Sirolimus results in decreased expression of CCND3 protein
Sirolimus inhibits the reaction [KITL protein results in increased expression of CCND3 protein]
Sirolimus results in decreased stability of CCND3 mRNA		 CTD PMID:10849422 PMID:12393642 PMID:15070696 PMID:15778701 PMID:15882288 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne1 cyclin E1 multiple interactions
increases expression		 ISO Curcumin inhibits the reaction [Sirolimus results in increased expression of CCNE1 protein] CTD PMID:36640941 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccne2 cyclin E2 multiple interactions ISO [Fulvestrant co-treated with Sirolimus] results in decreased expression of CCNE2 mRNA; Sirolimus inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA] CTD PMID:19016759 PMID:27542212 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Ccng2 cyclin G2 multiple interactions
increases expression		 ISO [cotylenin A co-treated with Sirolimus] results in increased expression of CCNG2 mRNA; Sirolimus inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of CCNG2 mRNA]
Sirolimus results in increased expression of CCNG2 mRNA		 CTD PMID:18754885 PMID:21245298 PMID:24356939 PMID:27542212 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Ccni cyclin I multiple interactions ISO Sirolimus inhibits the reaction [IL2 protein results in decreased expression of CCNI mRNA] CTD PMID:11355896 NCBI chr14:14,879,698...14,902,510
Ensembl chr14:14,879,717...14,902,510 		JBrowse link
G Cd36 CD36 molecule affects expression
multiple interactions		 ISO Sirolimus affects the expression of CD36 protein
Sirolimus inhibits the reaction [Oxygen deficiency results in increased expression of CD36 mRNA]		 CTD PMID:17016853 PMID:19640849 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd38 CD38 molecule multiple interactions ISO CD38 gene mutant form promotes the reaction [Sirolimus results in increased expression of MAP1LC3B protein]; CD38 mutant form inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein] CTD PMID:24238063 PMID:24445604 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cd68 Cd68 molecule decreases expression ISO
EXP		 Sirolimus results in decreased expression of CD68 mRNA CTD PMID:17016853 PMID:21865292 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cd80 Cd80 molecule decreases expression ISO Sirolimus results in decreased expression of CD80 protein CTD PMID:12531798 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd84 CD84 molecule increases expression ISO Sirolimus results in increased expression of CD84 mRNA CTD PMID:24356939 NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076 		JBrowse link
G Cd86 CD86 molecule decreases expression ISO Sirolimus results in decreased expression of CD86 protein CTD PMID:12531798 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of CDC20 mRNA CTD PMID:19016759 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions		 ISO
EXP		 Sirolimus results in increased expression of CDH1 protein
NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 mRNA]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]; Sirolimus promotes the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]; Sirolimus promotes the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein]
Sirolimus inhibits the reaction [sodium arsenite results in decreased expression of CDH1 protein]		 CTD PMID:28624451 PMID:28888487 PMID:30053495 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions EXP Sirolimus promotes the reaction [Dibutyl Phthalate results in increased expression of CDH2 mRNA]; Sirolimus promotes the reaction [Dibutyl Phthalate results in increased expression of CDH2 protein] CTD PMID:30053495 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases activity
decreases expression		 ISO
EXP		 [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CDK1 mRNA; [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CDK1 protein; [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of CDK1 protein; [fulvestrant co-treated with Sirolimus] results in decreased expression of CDK1 mRNA
Sirolimus results in decreased activity of CDK1 protein
Sirolimus results in decreased expression of CDK1 mRNA; Sirolimus results in decreased expression of CDK1 protein
Sirolimus inhibits the reaction [IL2 protein results in increased expression of CDK1 mRNA]		 CTD PMID:7503980 PMID:7532117 PMID:8419408 PMID:11355896 PMID:15767555 More... NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases activity		 ISO
EXP		 [Sirolimus co-treated with TGFB1 protein] affects the localization of CDK2 protein; [Sirolimus co-treated with TGFB1 protein] promotes the reaction [CDKN1A protein binds to CDK2 protein]; [TGFB1 protein co-treated with Sirolimus] inhibits the reaction [[E2F4 protein binds to RBL1 protein] which binds to CDK2 protein]; [TGFB1 protein co-treated with Sirolimus] inhibits the reaction [[E2F4 protein binds to RBL2 protein] which binds to CDK2 protein]; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1A protein]; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1B protein]; [TGFB1 protein co-treated with Sirolimus] results in decreased activity of CDK2 protein; [TGFB1 protein co-treated with Sirolimus] results in decreased phosphorylation of CDK2 protein
[Sirolimus co-treated with TGFB1 protein] affects the localization of CDK2 protein; [Sirolimus co-treated with TGFB1 protein] promotes the reaction [CDKN1B protein binds to CDK2 protein]; [Sirolimus co-treated with TGFB1 protein] results in decreased activity of CDK2 protein; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1B protein]
Sirolimus results in decreased activity of CDK2 protein		 CTD PMID:7532117 PMID:12393642 PMID:12417722 PMID:14979923 PMID:21528311 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Sirolimus results in decreased expression of CDK4 protein CTD PMID:22761470 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases expression
increases expression		 ISO
EXP		 [(+)-JQ1 compound co-treated with Sirolimus] results in increased expression of CDKN1A mRNA; [(+)-JQ1 compound co-treated with Sirolimus] results in increased expression of CDKN1A protein; [S 1 (combination) co-treated with Sirolimus] results in increased expression of CDKN1A protein; [Sirolimus co-treated with TGFB1 protein] promotes the reaction [CDKN1A protein binds to CDK2 protein]; [Sirolimus co-treated with TGFB1 protein] results in increased expression of CDKN1A protein; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1A protein]; [TGFB1 protein co-treated with Sirolimus] results in increased expression of CDKN1A protein; Fluorouracil promotes the reaction [Sirolimus results in increased expression of CDKN1A mRNA]; Sirolimus inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]; Sirolimus promotes the reaction [(+)-JQ1 compound results in increased expression of CDKN1A mRNA]; Sirolimus promotes the reaction [(+)-JQ1 compound results in increased expression of CDKN1A protein]; Sirolimus promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; Sirolimus promotes the reaction [Fluorouracil results in increased expression of CDKN1A mRNA]
Sirolimus inhibits the reaction [arsenite results in increased expression of CDKN1A protein]
Sirolimus results in decreased expression of CDKN1A protein
Sirolimus results in increased expression of CDKN1A mRNA; Sirolimus results in increased expression of CDKN1A protein
Niacinamide inhibits the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]; Sirolimus inhibits the reaction [BTC protein affects the localization of CDKN1A protein]; Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1A protein]; Sirolimus inhibits the reaction [IGF1 protein affects the localization of CDKN1A protein]; Sirolimus inhibits the reaction [N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone results in increased expression of CDKN1A protein]; SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]		 CTD PMID:12417722 PMID:14979923 PMID:17700525 PMID:19105244 PMID:19764996 More... NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
decreases expression
increases expression
decreases degradation		 ISO
EXP		 [Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of CDKN1B protein; [Decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of CDKN1B mRNA; [Sirolimus co-treated with TGFB1 protein] affects the localization of CDKN1B protein; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1B protein]; Sirolimus promotes the reaction [Cisplatin results in increased expression of CDKN1B mRNA]
Sirolimus results in decreased expression of CDKN1B protein
Sirolimus results in increased expression of CDKN1B protein
Niacinamide inhibits the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]; Sirolimus inhibits the reaction [BTC protein affects the localization of CDKN1B protein]; Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]; Sirolimus inhibits the reaction [IGF1 protein affects the localization of CDKN1B protein]; SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]
[Sirolimus co-treated with TGFB1 protein] affects the localization of CDKN1B protein; [Sirolimus co-treated with TGFB1 protein] promotes the reaction [CDKN1B protein binds to CDK2 protein]; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1B protein]
Sirolimus results in decreased degradation of CDKN1B protein		 CTD PMID:12417722 PMID:12565877 PMID:14979923 PMID:15070696 PMID:16455087 More... NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdx2 caudal type homeo box 2 increases expression ISO Sirolimus results in increased expression of CDX2 mRNA CTD PMID:21681844 NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Sirolimus results in decreased expression of CEBPA mRNA CTD PMID:15358118 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO Sirolimus inhibits the reaction [Endrin results in increased expression of CEBPD mRNA] CTD PMID:34801515 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829 		JBrowse link
G Cenpx centromere protein X increases expression ISO Sirolimus results in increased expression of CENPX mRNA CTD PMID:11355896 NCBI chr10:105,991,469...105,994,310 JBrowse link
G Cfd complement factor D decreases expression ISO Sirolimus results in decreased expression of CFD mRNA CTD PMID:15358118 NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053 		JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of CHRNB3 mRNA] CTD PMID:21245298 NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360 		JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of CIDEC mRNA] CTD PMID:31499194 NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173 		JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B decreases expression ISO Sirolimus results in decreased expression of CKS1B mRNA CTD PMID:11355896 NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636 		JBrowse link
G Cldn7 claudin 7 increases expression EXP Sirolimus results in increased expression of CLDN7 mRNA CTD PMID:21865292 NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171 		JBrowse link
G Clec4a3 C-type lectin domain family 4, member A3 decreases expression EXP Sirolimus results in decreased expression of CLEC4A mRNA CTD PMID:21865292 NCBI chr 4:156,214,030...156,224,818
Ensembl chr 4:156,214,718...156,224,817 		JBrowse link
G Cluh clustered mitochondria homolog increases expression ISO Sirolimus results in increased expression of CLUH protein CTD PMID:36214828 NCBI chr10:59,509,580...59,531,345
Ensembl chr10:59,509,726...59,531,345 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions		 EXP
ISO		 Sirolimus results in decreased expression of COL1A1 mRNA
Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]		 CTD PMID:21865292 PMID:35405287 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO
EXP		 Sirolimus inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]
Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]		 CTD PMID:10535884 PMID:11343241 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression ISO Sirolimus results in decreased expression of COL2A1 protein CTD PMID:34536393 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Cp ceruloplasmin increases expression EXP Sirolimus results in increased expression of CP mRNA CTD PMID:21865292 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B multiple interactions EXP Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT1B mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT1B mRNA]] CTD PMID:25045214 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions EXP Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT2 mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT2 mRNA]] CTD PMID:25045214 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CREB1 protein]] CTD PMID:22363816 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crebrf CREB3 regulatory factor multiple interactions ISO [(+)-JQ1 compound co-treated with Sirolimus] affects the expression of CREBRF mRNA CTD PMID:25307878 NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999 		JBrowse link
G Crtc2 CREB regulated transcription coactivator 2 decreases activity ISO Sirolimus results in decreased activity of CRTC2 protein CTD PMID:23440206 NCBI chr 2:175,709,603...175,719,768
Ensembl chr 2:175,709,644...175,719,763 		JBrowse link
G Cs citrate synthase multiple interactions ISO Sirolimus affects the reaction [triethylene glycol dimethacrylate affects the activity of CS protein] CTD PMID:33684387 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Cse1l chromosome segregation 1 like decreases expression ISO Sirolimus results in decreased expression of CSE1L mRNA CTD PMID:11355896 NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865 		JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO Sirolimus inhibits the reaction [CSF1 protein results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [CSF1 protein results in increased phosphorylation of RPS6 protein] CTD PMID:14502240 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Sirolimus inhibits the reaction [Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CSF2 protein]] CTD PMID:1376361 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Sirolimus promotes the reaction [Dibutyl Phthalate results in increased expression of CTNNB1 mRNA] CTD PMID:30053495 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsk cathepsin K multiple interactions
decreases expression		 ISO PDCD4 mutant form inhibits the reaction [Sirolimus inhibits the reaction [Pasteurella multocida toxin results in increased expression of CTSK mRNA]]; Sirolimus inhibits the reaction [Pasteurella multocida toxin results in increased activity of CTSK protein]; Sirolimus inhibits the reaction [Pasteurella multocida toxin results in increased expression of CTSK mRNA]
Sirolimus results in decreased expression of CTSK mRNA		 CTD PMID:26369790 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Sirolimus results in decreased expression of CXCL10 mRNA CTD PMID:21865292 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 decreases expression EXP Sirolimus results in decreased expression of CXCL13 mRNA CTD PMID:21865292 NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein] CTD PMID:21195169 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein] CTD PMID:21195169 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Sirolimus results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions
decreases activity		 ISO [Cyclosporine co-treated with Sirolimus] results in decreased activity of CYP27A1 protein
Sirolimus results in decreased activity of CYP27A1 protein		 CTD PMID:17516993 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Sirolimus results in increased expression of CYP2B6 mRNA CTD PMID:25929522 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Sirolimus affects the reaction [FXN protein affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]] CTD PMID:33017621 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Sirolimus; CYP3A4 protein polymorphism affects the metabolism of Sirolimus CTD PMID:15707415 PMID:15964407 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO
EXP		 Sirolimus inhibits the reaction [arsenite results in increased expression of DDIT3 protein]; Sirolimus inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 protein]
[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of DDIT3 mRNA; [Sirolimus results in decreased activity of MTOR protein] which results in decreased expression of DDIT3 protein; Sirolimus inhibits the reaction [arsenite results in increased expression of DDIT3 mRNA]; Sirolimus inhibits the reaction [arsenite results in increased expression of DDIT3 protein]; Sirolimus inhibits the reaction [honokiol results in increased expression of DDIT3 protein]
Sirolimus inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein]; Sirolimus inhibits the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein]; Sirolimus inhibits the reaction [TSC2 gene mutant form results in increased expression of DDIT3 protein]		 CTD PMID:11145585 PMID:19420259 PMID:21321189 PMID:22215663 PMID:25307878 More... NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression
decreases expression		 EXP Sirolimus results in increased expression of DDIT4L mRNA
Sirolimus results in decreased expression of DDIT4L mRNA		 CTD PMID:21865292 NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375 		JBrowse link
G Deptor DEP domain containing MTOR-interacting protein multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of DEPTOR mRNA] CTD PMID:21245298 NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO [7-hydroxystaurosporine co-treated with Sirolimus] affects the localization of DIABLO protein; Boc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] affects the localization of DIABLO protein] CTD PMID:15767555 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO Sirolimus inhibits the reaction [Ketamine results in increased expression of DLG4 protein] CTD PMID:33022268 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 decreases expression EXP Sirolimus results in decreased expression of DNAJC6 mRNA CTD PMID:21865292 NCBI chr 5:116,120,069...116,283,448
Ensembl chr 5:116,119,676...116,283,448 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased cleavage of DNM1L protein] CTD PMID:35405287 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of DNMT1 mRNA CTD PMID:19016759 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases expression ISO Sirolimus results in decreased expression of DPYD mRNA CTD PMID:19764996 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO Sirolimus results in increased expression of DUSP10 mRNA CTD PMID:24356939 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dusp15 dual specificity phosphatase 15 decreases expression EXP Sirolimus results in decreased expression of DUSP15 mRNA CTD PMID:21865292 NCBI chr 3:141,408,495...141,419,137
Ensembl chr 3:141,408,498...141,418,999 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [TGFB1 protein co-treated with Sirolimus] results in decreased expression of E2F1 mRNA; [TGFB1 protein co-treated with Sirolimus] results in decreased expression of E2F1 protein CTD PMID:12417722 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO [TGFB1 protein co-treated with Sirolimus] inhibits the reaction [[E2F4 protein binds to RBL1 protein] which binds to CDK2 protein]; [TGFB1 protein co-treated with Sirolimus] inhibits the reaction [[E2F4 protein binds to RBL2 protein] which binds to CDK2 protein] CTD PMID:12417722 NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Sirolimus inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]; Sirolimus inhibits the reaction [EDN1 protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:12411397 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases phosphorylation ISO Sirolimus results in increased phosphorylation of EEF2 protein CTD PMID:25940091 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Egf epidermal growth factor multiple interactions
decreases activity		 ISO Sirolimus inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]
Sirolimus analog results in decreased activity of EGF protein		 CTD PMID:12406821 PMID:21187475 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [Sirolimus results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of MAPK1 protein; [Sirolimus results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of MAPK3 protein; [Sirolimus results in increased phosphorylation of and results in increased activity of SRC protein] which results in increased phosphorylation of EGFR protein; AG 1879 inhibits the reaction [Sirolimus results in increased phosphorylation of EGFR protein]; Sirolimus results in increased phosphorylation of and results in increased activity of EGFR protein CTD PMID:19151764 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Sirolimus inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein] CTD PMID:37654027 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Sirolimus inhibits the reaction [cadmium acetate results in increased phosphorylation of EIF2S1 protein] CTD PMID:29870746 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eif4b eukaryotic translation initiation factor 4B multiple interactions
decreases phosphorylation		 ISO
EXP		 [resveratrol co-treated with Sirolimus] inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of EIF4B protein]; [Sirolimus co-treated with resveratrol] results in decreased phosphorylation of EIF4B protein; Sirolimus inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF4B protein]; Sirolimus inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of EIF4B protein]
Sirolimus results in decreased phosphorylation of EIF4B protein
[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of EIF4B protein		 CTD PMID:21268130 PMID:24304514 PMID:24375594 NCBI chr 7:133,206,637...133,228,436 JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions
increases expression
increases phosphorylation
decreases activity		 ISO
EXP		 EIF4E protein inhibits the reaction [Sirolimus results in decreased expression of MDM2 protein]
Sirolimus results in increased expression of EIF4E mRNA
Sirolimus results in increased phosphorylation of EIF4E protein
Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]
Sirolimus results in decreased activity of EIF4E protein		 CTD PMID:15757502 PMID:19560264 PMID:26282490 PMID:34453960 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
affects phosphorylation
decreases phosphorylation		 ISO
EXP		 [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of EIF4EBP1 protein; [Sirolimus co-treated with Cisplatin] results in decreased phosphorylation of EIF4EBP1 protein; [Sirolimus co-treated with Oxygen deficiency] results in increased phosphorylation of EIF4EBP1 protein; [Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of EIF4EBP1 protein; KIT protein mutant form promotes the reaction [Sirolimus results in decreased phosphorylation of EIF4EBP1 protein]; Sirolimus affects the reaction [Testosterone results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus promotes the reaction [Acetaldehyde results in decreased phosphorylation of EIF4EBP1 protein]; Sirolimus promotes the reaction [Cisplatin results in decreased phosphorylation of EIF4EBP1 protein]; Sirolimus promotes the reaction [EIF4EBP1 protein binds to 7-methylguanosine triphosphate]; Sirolimus promotes the reaction [sodium arsenite results in decreased phosphorylation of EIF4EBP1 protein]; Sirolimus results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein; sodium arsenite promotes the reaction [Sirolimus results in decreased phosphorylation of EIF4EBP1 protein]
Sirolimus affects the phosphorylation of EIF4EBP1 protein
Sirolimus inhibits the reaction [Cadmium results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [EDN1 protein results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]
Sirolimus inhibits the reaction [AKT1 protein mutant form results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [CSF1 protein results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [Polystyrenes analog results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [TNF protein results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [TNFSF11 protein results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus results in decreased phosphorylation of and results in increased activity of EIF4EBP1 protein; Tacrolimus inhibits the reaction [Sirolimus results in decreased phosphorylation of and results in increased activity of EIF4EBP1 protein]		 CTD PMID:8599949 PMID:8971030 PMID:11909977 PMID:12411397 PMID:12939469 More... NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma 1 multiple interactions ISO Sirolimus inhibits the reaction [EIF4G1 protein binds to 7-methylguanosine triphosphate]; Sirolimus inhibits the reaction [EIF4G1 protein binds to PABPC1 mRNA]; Sirolimus inhibits the reaction [EIF4G1 protein binds to RPL32 mRNA]; Sirolimus inhibits the reaction [EIF4G1 protein binds to RPS20 mRNA]; Sirolimus inhibits the reaction [EIF4G1 protein binds to RPS6 mRNA] CTD PMID:25940091 NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941 		JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 increases expression ISO Sirolimus results in increased expression of EIF4G2 protein CTD PMID:18491231 NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588 		JBrowse link
G Eno2 enolase 2 multiple interactions
increases expression		 EXP 3-methyladenine inhibits the reaction [Sirolimus results in increased expression of ENO2 protein]; Chloroquine inhibits the reaction [Sirolimus results in increased expression of ENO2 protein] CTD PMID:26676567 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Sirolimus co-treated with HRAS protein] results in decreased expression of ERN1 protein; PPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of ERN1 protein]
Sirolimus inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]		 CTD PMID:24898257 PMID:32283200 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha multiple interactions EXP Sirolimus inhibits the reaction [TSC2 gene mutant form results in increased expression of ERO1A mRNA] CTD PMID:19420259 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478 		JBrowse link
G Espl1 extra spindle pole bodies like 1, separase multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of ESPL1 mRNA CTD PMID:19016759 NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984 		JBrowse link
G Esr1 estrogen receptor 1 increases expression
increases phosphorylation		 ISO Sirolimus results in increased expression of ESR1 protein
Sirolimus results in increased phosphorylation of ESR1 protein		 CTD PMID:19016759 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Evi2a ecotropic viral integration site 2A increases expression ISO Sirolimus results in increased expression of EVI2A mRNA CTD PMID:24356939 NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843 		JBrowse link
G Ewsr1 EWS RNA-binding protein 1 decreases expression ISO Sirolimus results in decreased expression of EWSR1 protein mutant form CTD PMID:15782132 NCBI chr14:79,965,365...79,994,108
Ensembl chr14:79,965,368...79,994,544 		JBrowse link
G F2 coagulation factor II, thrombin decreases expression EXP Sirolimus results in decreased expression of F2 mRNA CTD PMID:21865292 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
increases activity		 ISO Sirolimus promotes the reaction [TNF protein results in increased expression of F3 protein]
Sirolimus results in increased activity of F3 protein		 CTD PMID:19567381 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Sirolimus results in decreased expression of FAS mRNA CTD PMID:15358118 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand decreases secretion ISO Sirolimus results in decreased secretion of FASLG protein CTD PMID:11692113 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Faxdc2 fatty acid hydroxylase domain containing 2 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of FAXDC2 mRNA] CTD PMID:21245298 NCBI chr10:42,245,808...42,271,679
Ensembl chr10:42,246,868...42,271,871 		JBrowse link
G Fbln1 fibulin 1 increases expression EXP Sirolimus results in increased expression of FBLN1 mRNA CTD PMID:21865292 NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075 		JBrowse link
G Fbxo32 F-box protein 32 multiple interactions
increases expression		 ISO [(+)-JQ1 compound co-treated with Sirolimus] affects the expression of FBXO32 mRNA; Sirolimus inhibits the reaction [TP73 protein results in increased expression of FBXO32 mRNA]
Sirolimus results in increased expression of FBXO32 mRNA		 CTD PMID:21245298 PMID:24356939 PMID:25307878 NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436 		JBrowse link
G Fbxo5 F-box protein 5 multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of FBXO5 mRNA CTD PMID:19016759 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437 		JBrowse link
G Fcgr1a Fc gamma receptor 1A multiple interactions
decreases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide inhibits the reaction [Sirolimus results in decreased expression of FCGR1A protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Sirolimus results in decreased expression of FCGR1A protein]; arsenic trioxide inhibits the reaction [Sirolimus results in decreased expression of FCGR1A protein] CTD PMID:25758096 NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994 		JBrowse link
G Fgb fibrinogen beta chain decreases expression
increases expression		 EXP Sirolimus results in decreased expression of FGB mRNA
Sirolimus results in increased expression of FGB mRNA		 CTD PMID:21865292 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP [Sirolimus co-treated with Hydrogen Peroxide] results in increased expression of FGF1 mRNA; Sirolimus inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA] CTD PMID:15121739 PMID:31332898 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions ISO Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of FGF21 mRNA] CTD PMID:31499194 NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of FGF7 mRNA] CTD PMID:21245298 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A affects binding
multiple interactions		 ISO
EXP		 Sirolimus binds to FKBP1A protein
immunomycin inhibits the reaction [Sirolimus binds to FKBP1A protein]
[Sirolimus binds to FKBP1A protein] which results in decreased expression of IL2RG mRNA; [Sirolimus binds to FKBP1A protein] which results in decreased expression of IL2RG protein; [Sirolimus binds to FKBP1A protein] which results in decreased expression of IL4R mRNA; [Sirolimus binds to FKBP1A protein] which results in decreased expression of IL4R protein; [Sirolimus binds to FKBP1A protein] which results in increased expression of ACTB mRNA; immunomycin inhibits the reaction [Sirolimus binds to FKBP1A protein]
[Sirolimus binds to FKBP1A protein] which results in increased activity of TGFB1 protein; [Tacrolimus binds to FKBP1A protein] inhibits the reaction [Sirolimus binds to FKBP1A protein]		 CTD PMID:7503980 PMID:7532117 PMID:10361256 PMID:12417722 PMID:12531798 More... NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand decreases activity ISO Sirolimus results in decreased activity of FLT3LG protein CTD PMID:12531798 NCBI chr 1:95,615,056...95,620,463
Ensembl chr 1:95,609,370...95,620,463 		JBrowse link
G Folr1 folate receptor alpha multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of FOLR1 mRNA] CTD PMID:21245298 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667 		JBrowse link
G Foxm1 forkhead box M1 multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of FOXM1 mRNA CTD PMID:19016759 NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684 		JBrowse link
G Foxo1 forkhead box O1 increases phosphorylation ISO Sirolimus results in increased phosphorylation of FOXO1 protein CTD PMID:16227402 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
increases phosphorylation		 ISO [Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of BCL2L11 protein; [Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of CDKN1B protein; Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]; Sirolimus promotes the reaction [Cisplatin results in increased expression of and results in increased localization of and results in increased activity of FOXO3 protein]; Sirolimus results in decreased degradation of and results in increased phosphorylation of FOXO3 protein CTD PMID:21092744 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Foxp1 forkhead box P1 decreases expression ISO Sirolimus results in decreased expression of FOXP1 protein CTD PMID:25663935 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Foxp3 forkhead box P3 multiple interactions
increases expression		 ISO [TGFB1 protein modified form co-treated with Sirolimus] results in increased expression of FOXP3 mRNA; [TGFB1 protein modified form co-treated with Sirolimus] results in increased expression of FOXP3 protein
Sirolimus results in increased expression of FOXP3 mRNA		 CTD PMID:20844194 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Frat1 FRAT regulator of WNT signaling pathway 1 increases expression ISO Sirolimus results in increased expression of FRAT1 mRNA CTD PMID:24356939 NCBI chr 1:240,638,309...240,640,857
Ensembl chr 1:240,638,296...240,640,945 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Sirolimus inhibits the reaction [FSHB protein results in increased expression of CCND2 mRNA] CTD PMID:17510244 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of FTL mRNA] CTD PMID:21245298 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725 		JBrowse link
G Fxn frataxin multiple interactions ISO Sirolimus affects the reaction [FXN protein affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]] CTD PMID:33017621 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G Gabarap GABA type A receptor-associated protein increases expression ISO Sirolimus results in increased expression of GABARAP mRNA CTD PMID:21681844 NCBI chr10:54,714,777...54,718,099
Ensembl chr10:54,714,198...54,717,765 		JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 multiple interactions ISO Sirolimus affects the localization of and results in increased lipidation of GABARAPL1 protein CTD PMID:15888080 NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450 		JBrowse link
G Gcm2 glial cells missing transcription factor 2 multiple interactions ISO Sirolimus promotes the reaction [TP73 protein affects the activity of GCM2 protein] CTD PMID:21245298 NCBI chr17:23,652,637...23,661,754
Ensembl chr17:23,652,637...23,661,754 		JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle multiple interactions ISO [(+)-JQ1 compound co-treated with Sirolimus] affects the expression of GEM mRNA CTD PMID:25307878 NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP Sirolimus promotes the reaction [Cyclosporine affects the expression of GGT1 protein] CTD PMID:11589784 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO Sirolimus results in decreased expression of GJA1 protein CTD PMID:35750204 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions
decreases expression		 EXP Niacinamide inhibits the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of GLB1 protein]]; Sirolimus inhibits the reaction [Glucose results in increased expression of GLB1 protein]; SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of GLB1 protein]]
Sirolimus results in decreased expression of GLB1 protein		 CTD PMID:22561310 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127 		JBrowse link
G Gnai1 G protein subunit alpha i1 multiple interactions ISO Sirolimus inhibits the reaction [Dronabinol promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of GNAI1 protein]] CTD PMID:29748632 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnai3 G protein subunit alpha i3 multiple interactions ISO Sirolimus inhibits the reaction [Dronabinol promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of GNAI3 protein]] CTD PMID:29748632 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742 		JBrowse link
G Gnaz G protein subunit alpha z multiple interactions ISO Sirolimus inhibits the reaction [Dronabinol promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of GNAZ protein]] CTD PMID:29748632 NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,640...13,669,907 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions ISO Sirolimus inhibits the reaction [puerarin results in increased expression of GPER1 protein] CTD PMID:27796870 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Sirolimus results in increased expression of GPNMB mRNA CTD PMID:21865292 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367 		JBrowse link
G Gpr18 G protein-coupled receptor 18 increases expression ISO Sirolimus results in increased expression of GPR18 mRNA CTD PMID:24356939 NCBI chr15:98,997,427...99,001,177
Ensembl chr15:98,997,259...99,001,470 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO		 Sirolimus promotes the reaction [Cyclosporine affects the expression of GPT protein]
Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased activity of GPT protein]]		 CTD PMID:11589784 PMID:31499194 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsdmd gasdermin D multiple interactions EXP Sirolimus inhibits the reaction [Lipopolysaccharides results in increased expression of GSDMD protein] CTD PMID:37654027 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases activity		 ISO [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]; [Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]; [SB 216763 results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]; [Sirolimus results in decreased activity of MTOR protein] which results in increased phosphorylation of GSK3B protein; [Sirolimus results in increased activity of GSK3B protein] which results in increased phosphorylation of and results in increased degradation of CCND1 protein
Sirolimus inhibits the reaction [TSC1 gene mutant form results in decreased phosphorylation of GSK3B protein]		 CTD PMID:15753396 PMID:17908691 PMID:18495876 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases response to substance ISO GSTT1 gene mutant form results in increased susceptibility to Sirolimus CTD PMID:12916871 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Gtpbp4 GTP binding protein 4 decreases expression EXP Sirolimus results in decreased expression of GTPBP4 mRNA CTD PMID:21865292 NCBI chr17:61,308,033...61,328,184
Ensembl chr17:61,308,014...61,418,009 		JBrowse link
G Guca2a guanylate cyclase activator 2A increases expression EXP Sirolimus results in increased expression of GUCA2A mRNA CTD PMID:21865292 NCBI chr 5:133,237,177...133,239,019
Ensembl chr 5:133,237,177...133,239,018 		JBrowse link
G Gzmb granzyme B decreases expression ISO Sirolimus results in decreased expression of GZMB protein CTD PMID:16477233 NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814 		JBrowse link
G H2ax H2A.X variant histone decreases expression ISO Sirolimus results in decreased expression of H2AX protein CTD PMID:23363784 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP Sirolimus results in increased expression of HAVCR1 mRNA CTD PMID:21865292 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hbp1 HMG-box transcription factor 1 multiple interactions ISO [(+)-JQ1 compound co-treated with Sirolimus] affects the expression of HBP1 mRNA; Sirolimus inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA] CTD PMID:25307878 PMID:27542212 NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 decreases expression ISO Sirolimus results in decreased expression of HES1 protein
Sirolimus results in decreased expression of HES1 mRNA; Sirolimus results in decreased expression of HES1 protein		 CTD PMID:20038814 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression		 ISO
EXP		 [Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Oxygen deficiency inhibits the reaction [Sirolimus inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]]; Sirolimus inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; Sirolimus inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [sulprostone results in increased expression of HIF1A protein]
Sirolimus inhibits the reaction [cyanoginosin LR results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [Polystyrenes analog results in increased expression of HIF1A protein]
Sirolimus results in decreased expression of HIF1A mRNA
Sirolimus results in decreased expression of HIF1A protein		 CTD PMID:15050414 PMID:15297429 PMID:15634505 PMID:16682453 PMID:17968710 More... NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hk2 hexokinase 2 multiple interactions
decreases expression		 ISO Curcumin promotes the reaction [Sirolimus results in decreased expression of HK2 protein]; Sirolimus inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HK2 protein]; Sirolimus inhibits the reaction [ATG4B protein results in increased expression of HK2 protein] CTD PMID:36336208 PMID:36640941 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Sirolimus results in increased expression of HMGCR mRNA CTD PMID:17516993 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 Sirolimus results in increased expression of HMOX1
Sirolimus inhibits the reaction [TSC2 gene mutant form results in increased expression of HMOX1 protein]		 CTD PMID:17003813 PMID:19420259 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D decreases expression
increases expression		 ISO
EXP		 Sirolimus results in decreased expression of HNRNPD protein
Sirolimus results in increased expression of HNRNPD protein		 CTD PMID:17603996 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786 		JBrowse link
G Hoxa9 homeobox A9 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein affects the activity of HOXA9 protein] CTD PMID:21245298 NCBI chr 4:81,323,235...81,329,344
Ensembl chr 4:81,323,382...81,326,358 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [Sirolimus co-treated with HRAS protein] results in decreased expression of ERN1 protein; [Sirolimus co-treated with HRAS protein] results in decreased expression of HSPA5 protein; PPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of ERN1 protein]; PPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of HSPA5 protein]
Sirolimus inhibits the reaction [HRAS protein mutant form results in increased expression of MIR146A mRNA]; Sirolimus inhibits the reaction [HRAS protein mutant form results in increased expression of MIR193A-1 mRNA]; Sirolimus inhibits the reaction [HRAS protein mutant form results in increased phosphorylation of RPS6 protein]		 CTD PMID:24898257 PMID:30619488 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Sirolimus results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression ISO Sirolimus results in decreased expression of HSPA1B mRNA CTD PMID:24356939 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
multiple interactions		 ISO
EXP		 Sirolimus results in decreased expression of HSPA5 mRNA
Sirolimus inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]
[Sirolimus co-treated with HRAS protein] results in decreased expression of HSPA5 protein; PPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of HSPA5 protein]		 CTD PMID:24356939 PMID:24898257 PMID:29870746 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspb8 heat shock protein family B (small) member 8 decreases expression ISO Sirolimus results in decreased expression of HSPB8 protein CTD PMID:21233418 NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185 		JBrowse link
G Ibsp integrin-binding sialoprotein multiple interactions ISO Sirolimus inhibits the reaction [Ketoglutaric Acids results in increased expression of IBSP protein] CTD PMID:31051157 NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Sirolimus results in decreased expression of ICAM1 protein CTD PMID:12531798 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id1 inhibitor of DNA binding 1 increases expression ISO Sirolimus results in increased expression of ID1 mRNA CTD PMID:23824090 PMID:24356939 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases secretion		 ISO Sirolimus inhibits the reaction [IFNG protein results in decreased phosphorylation of STAT3 protein]
Sirolimus inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]
Sirolimus results in decreased secretion of IFNG protein		 CTD PMID:11692113 PMID:16427044 PMID:21600178 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases response to substance		 ISO
EXP		 [Dexamethasone co-treated with Sirolimus] inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]; [Dexamethasone co-treated with Sirolimus] results in decreased activity of IGF1 protein; [Sirolimus co-treated with IGF1 protein] results in increased expression of ACTA2 protein; [Sirolimus co-treated with IGF1 protein] results in increased expression of CALD1 protein; [Sirolimus co-treated with IGF1 protein] results in increased expression of MYH11 protein; Sirolimus inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [IGF1 protein results in increased secretion of IGFBP3 protein]; Sirolimus inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]
Sirolimus inhibits the reaction [[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]; Sirolimus inhibits the reaction [IGF1 protein affects the localization of CDKN1A protein]; Sirolimus inhibits the reaction [IGF1 protein affects the localization of CDKN1B protein]; Sirolimus inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; Sirolimus inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]
Sirolimus results in increased susceptibility to IGF1 protein
Sirolimus inhibits the reaction [IL2 protein results in increased expression of IGF1 mRNA]		 CTD PMID:11355896 PMID:15070696 PMID:15297429 PMID:16227402 PMID:16682453 More... NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects activity
multiple interactions		 ISO Sirolimus affects the activity of IGF1R protein
Sirolimus promotes the reaction [IGF1R protein binds to and results in increased phosphorylation of IRS1 protein]		 CTD PMID:16227402 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Sirolimus results in increased expression of IGFBP1 mRNA CTD PMID:21865292 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions ISO Sirolimus inhibits the reaction [IGF1 protein results in increased secretion of IGFBP3 protein] CTD PMID:16682453 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases expression EXP Sirolimus results in decreased expression of IGFBP5 mRNA CTD PMID:21865292 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156 		JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression		 ISO Sirolimus inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; Sirolimus inhibits the reaction [lipoteichoic acid results in increased expression of IL10 protein]; Sirolimus inhibits the reaction [Peptidoglycan results in increased expression of IL10 protein]
Sirolimus results in decreased expression of IL10 mRNA
Sirolimus results in decreased expression of IL10 protein
[Sirolimus co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL10 protein; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]]		 CTD PMID:11169223 PMID:15588918 PMID:31499194 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Sirolimus inhibits the reaction [IL4 protein results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:12531798 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Sirolimus inhibits the reaction [IL4 protein results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:12531798 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Sirolimus inhibits the reaction [Trichloroethylene results in increased expression of IL17A protein] CTD PMID:36849104 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il17rb interleukin 17 receptor B multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of IL17RB mRNA CTD PMID:19016759 NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO Sirolimus inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]
Sirolimus inhibits the reaction [Particulate Matter results in increased expression of IL18 protein]		 CTD PMID:30205151 PMID:38237716 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
affects expression		 ISO
EXP		 [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Sirolimus inhibits the reaction [[Rotenone co-treated with Particulate Matter] results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased cleavage of IL1B protein]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; Sirolimus inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]; Sirolimus inhibits the reaction [Poloxalene results in increased expression of IL1B protein]; Sirolimus inhibits the reaction [Trichloroethylene results in increased expression of IL1B mRNA]
Sirolimus inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]
Sirolimus results in increased expression of IL1B mRNA
Sirolimus inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]]
Sirolimus results in increased expression of IL1B protein
Sirolimus affects the expression of IL1B mRNA		 CTD PMID:22363816 PMID:23211629 PMID:24971338 PMID:25045214 PMID:29594315 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions
affects expression
decreases response to substance		 ISO
EXP		 [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased phosphorylation of RB1 protein]; [Sirolimus co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA; Sirolimus inhibits the reaction [IL2 protein results in increased expression of CCND2 mRNA]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of CCND3 mRNA]; Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RB1 protein]; Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RBL2 protein]; Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]
Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 protein]]
Sirolimus affects the expression of IL2 protein
[Sirolimus co-treated with IL2 protein] results in decreased expression of BCL2A1A mRNA; [Sirolimus co-treated with IL2 protein] results in increased expression of BCL2 mRNA; [Sirolimus co-treated with IL2 protein] results in increased expression of BCL2L1 mRNA; [Sirolimus co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 protein; Sirolimus inhibits the reaction [IL2 protein results in decreased expression of CCNI mRNA]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of ASNS mRNA]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of BAD mRNA]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of BNIP3 mRNA]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of BTK mRNA]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of CDK1 mRNA]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of IGF1 mRNA]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of MCM2 mRNA]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of MCM7 mRNA]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of PCNA mRNA]; Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]; Tacrolimus inhibits the reaction [Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]]
Sirolimus results in decreased susceptibility to IL2 protein		 CTD PMID:1614535 PMID:10373522 PMID:11355896 PMID:15588918 PMID:15778701 More... NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO Sirolimus inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2RA protein]; Sirolimus inhibits the reaction [Ionomycin results in increased secretion of IL2RA protein]; Sirolimus inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2RA protein] CTD PMID:8586487 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma multiple interactions ISO [Sirolimus binds to FKBP1A protein] which results in decreased expression of IL2RG mRNA; [Sirolimus binds to FKBP1A protein] which results in decreased expression of IL2RG protein CTD PMID:12531798 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il3 interleukin 3 multiple interactions ISO Sirolimus inhibits the reaction [Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL3 protein]] CTD PMID:1376361 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression		 ISO [Sirolimus co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL4 protein; Sirolimus inhibits the reaction [IL4 protein results in increased expression of [IL12A protein binds to IL12B protein]]
Sirolimus analog results in decreased expression of IL4 protein; Sirolimus results in decreased expression of IL4 protein		 CTD PMID:12406821 PMID:12531798 PMID:15588918 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il4r interleukin 4 receptor multiple interactions ISO [Sirolimus binds to FKBP1A protein] which results in decreased expression of IL4R mRNA; [Sirolimus binds to FKBP1A protein] which results in decreased expression of IL4R protein CTD PMID:12531798 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Il5 interleukin 5 decreases expression ISO Sirolimus analog results in decreased expression of IL5 protein CTD PMID:12406821 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
decreases expression		 ISO [Dexamethasone co-treated with Sirolimus] inhibits the reaction [IL6 protein results in increased phosphorylation of RPS6KB1 protein]; [Dexamethasone co-treated with Sirolimus] results in decreased activity of IL6 protein; [TGFB1 protein modified form co-treated with Sirolimus] results in decreased expression of IL6 mRNA; [TGFB1 protein modified form co-treated with Sirolimus] results in decreased expression of IL6 protein
Sirolimus inhibits the reaction [[Rotenone co-treated with Particulate Matter] results in increased expression of IL6 mRNA]
Sirolimus results in increased expression of IL6
Sirolimus results in decreased expression of IL6 mRNA		 CTD PMID:15070696 PMID:16314788 PMID:20844194 PMID:33823232 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ing4 inhibitor of growth family, member 4 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of ING4 mRNA] CTD PMID:21245298 NCBI chr 4:157,841,882...157,850,519
Ensembl chr 4:157,841,951...157,850,265 		JBrowse link
G Ins1 insulin 1 multiple interactions
decreases expression		 ISO
EXP		 Sirolimus inhibits the reaction [INS1 protein results in increased phosphorylation of RPS6KB1 protein]
Sirolimus results in decreased expression of INS1 protein
Sirolimus inhibits the reaction [Carbachol results in increased secretion of INS1 protein]; Sirolimus inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Sirolimus inhibits the reaction [INS1 protein results in increased expression of MIR122 mRNA]; Sirolimus inhibits the reaction [INS1 protein results in increased expression of MIR132 mRNA]; Sirolimus inhibits the reaction [INS1 protein results in increased expression of MIR212 mRNA]; Sirolimus inhibits the reaction [INS1 protein results in increased phosphorylation of RPS6KB1 protein]
Sirolimus inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]		 CTD PMID:14578291 PMID:20880397 PMID:21357504 PMID:23920219 PMID:26563389 More... NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO Sirolimus inhibits the reaction [cyanoginosin LR promotes the reaction [INS protein results in increased expression of RPS6KB1 protein modified form]]; Sirolimus inhibits the reaction [cyanoginosin LR promotes the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; Sirolimus inhibits the reaction [INS protein promotes the reaction [cyanoginosin LR results in increased expression of RPS6KB1 protein modified form]]; Sirolimus inhibits the reaction [INS protein promotes the reaction [cyanoginosin LR results in increased phosphorylation of IRS1 protein]]; Sirolimus inhibits the reaction [INS protein results in increased expression of IRS1 protein modified form]; Sirolimus inhibits the reaction [INS protein results in increased expression of MAPK1 protein modified form]; Sirolimus inhibits the reaction [INS protein results in increased expression of MAPK3 protein modified form]; Sirolimus inhibits the reaction [INS protein results in increased expression of RPS6KB1 protein modified form]; Sirolimus inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]; Sirolimus inhibits the reaction [INS protein results in increased phosphorylation of RPS6 protein] CTD PMID:20936651 PMID:28790194 PMID:28984034 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insig1 insulin induced gene 1 multiple interactions ISO [(+)-JQ1 compound co-treated with Sirolimus] affects the expression of INSIG1 mRNA CTD PMID:25307878 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Irs1 insulin receptor substrate 1 affects phosphorylation
decreases phosphorylation
decreases degradation
multiple interactions		 ISO Sirolimus affects the phosphorylation of IRS1 protein
Sirolimus results in decreased phosphorylation of IRS1 protein
Sirolimus results in decreased degradation of IRS1 protein
[Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased activity of IRS1 protein; Sirolimus inhibits the reaction [cyanoginosin LR promotes the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; Sirolimus inhibits the reaction [cyanoginosin LR results in increased phosphorylation of IRS1 protein]; Sirolimus inhibits the reaction [INS protein promotes the reaction [cyanoginosin LR results in increased phosphorylation of IRS1 protein]]; Sirolimus inhibits the reaction [INS protein results in increased expression of IRS1 protein modified form]; Sirolimus inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]; Sirolimus promotes the reaction [IGF1R protein binds to and results in increased phosphorylation of IRS1 protein]; Sirolimus promotes the reaction [IRS1 protein binds to PIK3R1 protein]		 CTD PMID:16227402 PMID:17908691 PMID:20936651 PMID:28984034 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Sirolimus co-treated with arsenic trioxide] results in increased expression of ITGAM protein]; [Sirolimus co-treated with arsenic trioxide] results in increased expression of ITGAM protein; Sirolimus promotes the reaction [Tretinoin results in increased localization of and results in increased expression of ITGAM protein]
Sirolimus results in increased expression of ITGAM protein		 CTD PMID:20574048 PMID:25758096 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgav integrin subunit alpha V decreases expression ISO Sirolimus results in decreased expression of ITGAV mRNA; Sirolimus results in decreased expression of ITGAV protein CTD PMID:19922502 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO Sirolimus results in decreased expression of JAG1 protein CTD PMID:20038814 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Jmy junction mediating and regulatory protein, p53 cofactor multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in decreased expression of JMY mRNA] CTD PMID:21245298 NCBI chr 2:24,662,104...24,730,955
Ensembl chr 2:24,668,854...24,731,006 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Sirolimus inhibits the reaction [Pasteurella multocida toxin results in increased phosphorylation of JUN protein] CTD PMID:26369790 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression
multiple interactions		 ISO Sirolimus results in increased expression of KEAP1 protein
Sirolimus inhibits the reaction [Resveratrol inhibits the reaction [Particulate Matter affects the expression of KEAP1 protein]]		 CTD PMID:29781141 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Kifap3 kinesin-associated protein 3 increases expression EXP Sirolimus results in increased expression of KIFAP3 mRNA CTD PMID:21865292 NCBI chr13:76,127,702...76,264,654
Ensembl chr13:76,127,696...76,264,650 		JBrowse link
G Kifc1 kinesin family member C1 decreases expression EXP Sirolimus results in decreased expression of KIFC1 mRNA CTD PMID:21865292 NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO KIT protein mutant form promotes the reaction [Sirolimus results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:16597595 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Kitlg KIT ligand multiple interactions ISO Sirolimus inhibits the reaction [KITL protein results in increased expression of CCND3 protein]; Sirolimus inhibits the reaction [KITL protein results in increased phosphorylation of RB1 protein] CTD PMID:10849422 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Klf2 KLF transcription factor 2 increases expression ISO Sirolimus results in increased expression of KLF2 mRNA CTD PMID:24356939 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
G Klf5 KLF transcription factor 5 increases expression EXP Sirolimus results in increased expression of KLF5 mRNA CTD PMID:21865292 NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445 		JBrowse link
G Klf6 KLF transcription factor 6 decreases phosphorylation ISO Sirolimus results in decreased phosphorylation of KLF6 protein CTD PMID:16611854 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570 		JBrowse link
G Klhl24 kelch-like family member 24 increases expression
multiple interactions		 ISO Sirolimus results in increased expression of KLHL24 mRNA
[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of KLHL24 mRNA		 CTD PMID:24356939 PMID:25307878 NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 decreases expression
increases expression
multiple interactions		 EXP
ISO		 Sirolimus results in decreased expression of KLK1C10 mRNA
Sirolimus results in increased expression of KLK3 protein
bicalutamide inhibits the reaction [Sirolimus results in increased expression of KLK3 protein]		 CTD PMID:18776922 PMID:21865292 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Klk1c9 kallikrein 1-related peptidase C9 decreases expression EXP Sirolimus results in decreased expression of KLK1C9 mRNA CTD PMID:21865292 NCBI chr 1:94,597,359...94,601,245
Ensembl chr 1:94,597,359...94,601,245 		JBrowse link
G L1cam L1 cell adhesion molecule affects response to substance ISO L1CAM affects the susceptibility to Sirolimus CTD PMID:21097529 NCBI chr  X:151,597,270...151,623,776
Ensembl chr  X:151,597,277...151,623,857 		JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression EXP Sirolimus results in increased expression of LAMC2 mRNA CTD PMID:21865292 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Larp1 La ribonucleoprotein 1, translational regulator multiple interactions
increases response to substance		 ISO LARP1 protein promotes the reaction [Sirolimus results in decreased expression of RPL32 protein]; LARP1 protein promotes the reaction [Sirolimus results in decreased expression of RPS20 protein]; LARP1 protein promotes the reaction [Sirolimus results in decreased expression of RPS6 protein]; Sirolimus inhibits the reaction [[MTOR protein binds to RAPTOR protein] which binds to LARP1 protein]; Sirolimus promotes the reaction [LARP1 protein binds to PABPC1 mRNA]; Sirolimus promotes the reaction [LARP1 protein binds to RPL32 mRNA]; Sirolimus promotes the reaction [LARP1 protein binds to RPS20 mRNA]; Sirolimus promotes the reaction [LARP1 protein binds to RPS6 mRNA]
LARP1 protein results in increased susceptibility to Sirolimus		 CTD PMID:25940091 NCBI chr10:42,191,378...42,246,361
Ensembl chr10:42,191,325...42,243,371 		JBrowse link
G Lat2 linker for activation of T cells family, member 2 increases response to substance ISO LAT2 protein results in increased susceptibility to Sirolimus CTD PMID:32587277 NCBI chr12:22,104,173...22,118,294
Ensembl chr12:22,104,219...22,118,288 		JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Sirolimus results in increased expression of LCN2 mRNA CTD PMID:21865292 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases expression		 ISO Curcumin inhibits the reaction [Sirolimus results in increased expression of LDHA protein]; Sirolimus inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LDHA protein]; Sirolimus inhibits the reaction [ATG4B protein results in increased expression of LDHA protein] CTD PMID:36336208 PMID:36640941 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO Sirolimus promotes the reaction [cypermethrin results in decreased expression of LIF protein] CTD PMID:37011868 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions ISO Sirolimus promotes the reaction [Isoproterenol results in increased phosphorylation of LIPE protein] CTD PMID:21042876 NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310 		JBrowse link
G Lmnb1 lamin B1 multiple interactions EXP Sirolimus inhibits the reaction [N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone results in increased expression of and affects the localization of LMNB1 protein] CTD PMID:38604309 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of MAD2L1 mRNA CTD PMID:19016759 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Maf1 MAF1 homolog, negative regulator of RNA polymerase III multiple interactions ISO [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Sirolimus] results in decreased degradation of MAF1 protein; Cycloheximide inhibits the reaction [Sirolimus results in increased expression of MAF1 protein]; Sirolimus results in increased expression of and results in decreased phosphorylation of MAF1 protein CTD PMID:31645432 NCBI chr 7:108,075,173...108,078,252
Ensembl chr 7:108,075,189...108,078,249 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions ISO [Sirolimus inhibits the reaction [MTOR protein binds to RPTOR protein]] which results in increased expression of MAP1LC3A protein alternative form CTD PMID:21742779 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
increases lipidation
multiple interactions
affects metabolic processing
affects localization		 ISO
EXP		 Sirolimus results in increased expression of MAP1LC3B mRNA; Sirolimus results in increased expression of MAP1LC3B protein; Sirolimus results in increased expression of MAP1LC3B protein modified form
Sirolimus results in increased lipidation of MAP1LC3B protein
[bisphenol A co-treated with Sirolimus] results in increased lipidation of MAP1LC3B protein; Curcumin inhibits the reaction [Sirolimus results in increased expression of MAP1LC3B protein]; PRKD2 protein affects the reaction [Sirolimus results in increased lipidation of MAP1LC3B protein]; Sirolimus inhibits the reaction [honokiol results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [2,4,4'-trichlorobiphenyl results in increased cleavage of MAP1LC3B protein]; Sirolimus promotes the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased cleavage of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; Sirolimus promotes the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [hydroquinone results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Particulate Matter results in increased expression of MAP1LC3B protein]; Sirolimus promotes the reaction [Sevoflurane results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [TNF protein results in increased expression of and results in increased lipidation of MAP1LC3B protein]
CD38 gene mutant form promotes the reaction [Sirolimus results in increased expression of MAP1LC3B protein]; Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased lipidation of MAP1LC3B protein]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased lipidation of MAP1LC3B protein]]; Sirolimus inhibits the reaction [VCP protein mutant form results in decreased expression of MAP1LC3B protein]; Sirolimus promotes the reaction [Ethanol results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Tunicamycin results in increased lipidation of MAP1LC3B protein]
Sirolimus affects the metabolism of MAP1LC3B protein
Sirolimus results in increased expression of MAP1LC3B mRNA; Sirolimus results in increased expression of MAP1LC3B protein modified form
3-methyladenine inhibits the reaction [Sirolimus results in increased expression of MAP1LC3B protein modified form]; saikosaponin D inhibits the reaction [Sirolimus results in increased cleavage of MAP1LC3B protein]; Sirolimus inhibits the reaction [Particulate Matter results in increased lipidation of and results in increased localization of MAP1LC3B protein]; Sirolimus inhibits the reaction [saikosaponin D results in decreased cleavage of MAP1LC3B protein]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased lipidation of MAP1LC3B protein]]; Sirolimus promotes the reaction [2,4,4'-trichlorobiphenyl results in increased cleavage of MAP1LC3B protein]; Sirolimus promotes the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased cleavage of MAP1LC3B protein]; Sirolimus promotes the reaction [Lipopolysaccharides results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of MAP1LC3B protein]]; Sirolimus results in increased expression of and results in increased cleavage of MAP1LC3B protein
Sirolimus affects the localization of MAP1LC3B protein		 CTD PMID:18640276 PMID:19815708 PMID:21212465 PMID:21681844 PMID:23680031 More... NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions
increases expression		 EXP 3-methyladenine inhibits the reaction [Sirolimus results in increased expression of MAP2 protein]; Chloroquine inhibits the reaction [Sirolimus results in increased expression of MAP2 protein] CTD PMID:26676567 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO
EXP		 [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of MAP2K1 protein; [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of MAP2K1 protein
Sirolimus inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]; Sirolimus inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein]		 CTD PMID:12411397 PMID:15767555 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of MAP2K2 protein CTD PMID:15767555 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
affects phosphorylation
increases phosphorylation
decreases phosphorylation		 ISO
EXP		 [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [Sirolimus results in increased phosphorylation of MAPK1 protein]; Arsenic Trioxide inhibits the reaction [Sirolimus results in increased phosphorylation of MAPK1 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Sirolimus inhibits the reaction [INS protein results in increased expression of MAPK1 protein modified form]
Sirolimus affects the phosphorylation of MAPK1 protein
Sirolimus inhibits the reaction [[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]; Sirolimus inhibits the reaction [dehydroacetic acid results in increased phosphorylation of MAPK1 protein]
[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; [Sirolimus results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of MAPK1 protein; [Sirolimus results in increased phosphorylation of and results in increased activity of SRC protein] which results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [Sirolimus results in increased phosphorylation of MAPK1 protein]
Sirolimus results in decreased phosphorylation of MAPK1 protein		 CTD PMID:15767555 PMID:16255777 PMID:18374093 PMID:19151764 PMID:20936651 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
affects phosphorylation
increases phosphorylation
decreases phosphorylation		 ISO
EXP		 [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [Sirolimus results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide inhibits the reaction [Sirolimus results in increased phosphorylation of MAPK3 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Sirolimus inhibits the reaction [INS protein results in increased expression of MAPK3 protein modified form]
Sirolimus inhibits the reaction [dehydroacetic acid results in increased phosphorylation of MAPK3 protein]
Sirolimus affects the phosphorylation of MAPK3 protein
Sirolimus results in decreased phosphorylation of MAPK3 protein
[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; [Sirolimus results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of MAPK3 protein; [Sirolimus results in increased phosphorylation of and results in increased activity of SRC protein] which results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [Sirolimus results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15767555 PMID:16255777 PMID:16391472 PMID:18374093 PMID:19151764 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [7-hydroxystaurosporine co-treated with Sirolimus] results in increased phosphorylation of MAPK8 protein; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased phosphorylation of MAPK8 protein] CTD PMID:15767555 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Sirolimus results in decreased expression of and results in decreased cleavage of MAPT protein CTD PMID:33124469 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mbnl2 muscleblind-like splicing regulator 2 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of MBNL2 mRNA] CTD PMID:21245298 NCBI chr15:97,385,278...97,542,924
Ensembl chr15:97,385,244...97,542,937 		JBrowse link
G Mbp myelin basic protein increases expression ISO Sirolimus results in increased expression of MBP protein CTD PMID:20739560 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of MCL1 protein; [Sirolimus co-treated with Arsenic Trioxide] results in decreased expression of MCL1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Sirolimus inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; MCL1 protein inhibits the reaction [Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; MCL1 protein inhibits the reaction [Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; Sirolimus inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased stability of and results in decreased ubiquitination of MCL1 protein] CTD PMID:15767555 PMID:25758096 PMID:32802178 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions ISO Sirolimus inhibits the reaction [IL2 protein results in increased expression of MCM2 mRNA] CTD PMID:11355896 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 multiple interactions ISO Sirolimus inhibits the reaction [IL2 protein results in increased expression of MCM7 mRNA] CTD PMID:11355896 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions
decreases expression		 ISO EIF4E protein inhibits the reaction [Sirolimus results in decreased expression of MDM2 protein]; Sirolimus inhibits the reaction [Pravastatin results in increased phosphorylation of MDM2 protein]; Sirolimus promotes the reaction [TP73 protein binds to MDM2 promoter] CTD PMID:15625077 PMID:19560264 PMID:21245298 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mir122 microRNA 122 multiple interactions EXP Sirolimus inhibits the reaction [INS1 protein results in increased expression of MIR122 mRNA] CTD PMID:23920219 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir132 microRNA 132 multiple interactions EXP Sirolimus inhibits the reaction [INS1 protein results in increased expression of MIR132 mRNA] CTD PMID:23920219 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796 		JBrowse link
G Mir146a microRNA 146a multiple interactions ISO Sirolimus inhibits the reaction [HRAS protein mutant form results in increased expression of MIR146A mRNA] CTD PMID:30619488 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir151 microRNA 151 multiple interactions ISO TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR151 mRNA] CTD PMID:21245298 NCBI chr 7:105,172,377...105,172,473 JBrowse link
G Mir181a2 microRNA 181a-2 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in decreased expression of MIR181A2 mRNA] CTD PMID:21245298 NCBI chr 3:22,615,845...22,615,961
Ensembl chr 3:22,615,845...22,615,961 		JBrowse link
G Mir190 microRNA 190 multiple interactions ISO TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR190A mRNA] CTD PMID:21245298 NCBI chr 8:67,850,987...67,851,071
Ensembl chr 8:67,850,987...67,851,071 		JBrowse link
G Mir212 microRNA 212 multiple interactions EXP Sirolimus inhibits the reaction [INS1 protein results in increased expression of MIR212 mRNA] CTD PMID:23920219 NCBI chr10:60,023,403...60,023,513
Ensembl chr10:60,023,403...60,023,513 		JBrowse link
G Mir324 microRNA 324 multiple interactions ISO TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR324 mRNA] CTD PMID:21245298 NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766 		JBrowse link
G Mir330 microRNA 330 multiple interactions ISO [(+)-JQ1 compound co-treated with Sirolimus] affects the expression of MIR330 mRNA CTD PMID:25307878 NCBI chr 1:78,833,178...78,833,274
Ensembl chr 1:78,833,178...78,833,274 		JBrowse link
G Mir433 microRNA 433 multiple interactions ISO TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR433 mRNA] CTD PMID:21245298 NCBI chr 6:128,545,119...128,545,211
Ensembl chr 6:128,545,112...128,545,217 		JBrowse link
G Mir503 microRNA 503 multiple interactions ISO TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR503 mRNA] CTD PMID:21245298 NCBI chr  X:132,806,303...132,806,373
Ensembl chr  X:132,806,303...132,806,373 		JBrowse link
G Mir760 microRNA 760 multiple interactions ISO TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR760 mRNA] CTD PMID:21245298 NCBI chr 2:210,392,616...210,392,695
Ensembl chr 2:210,392,616...210,392,695 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression
affects expression
multiple interactions		 ISO
EXP		 Sirolimus results in decreased expression of MKI67 protein
Sirolimus affects the expression of MKI67 mRNA
[ABT-737 co-treated with Sirolimus] results in decreased expression of MKI67 protein		 CTD PMID:19773376 PMID:24971338 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog multiple interactions ISO Sirolimus results in decreased activity of [MTOR protein binds to RPTOR protein binds to MLST8 protein] CTD PMID:19505958 NCBI chr10:13,498,377...13,504,128
Ensembl chr10:13,498,388...13,504,128 		JBrowse link
G Mmp1 matrix metallopeptidase 1 increases secretion
increases expression		 ISO Sirolimus results in increased secretion of MMP1 protein
Sirolimus results in increased expression of MMP1 mRNA		 CTD PMID:21742783 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression		 EXP
ISO		 Sirolimus inhibits the reaction [Thioacetamide results in increased activity of MMP2 protein]
Sirolimus results in increased expression of MMP2 protein
Curcumin inhibits the reaction [Sirolimus results in increased expression of MMP2 protein]; Sirolimus inhibits the reaction [Chloroquine results in decreased expression of MMP2 protein]; Sirolimus inhibits the reaction [Hydroxychloroquine results in decreased expression of MMP2 protein]		 CTD PMID:17050028 PMID:34278709 PMID:36640941 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
increases expression
multiple interactions		 EXP
ISO		 Sirolimus results in decreased expression of MMP9 mRNA
Sirolimus results in increased expression of MMP9 protein
Curcumin inhibits the reaction [Sirolimus results in increased expression of MMP9 protein]
Sirolimus promotes the reaction [cypermethrin results in decreased expression of MMP9 protein]		 CTD PMID:21865292 PMID:36640941 PMID:37011868 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpz myelin protein zero increases expression ISO Sirolimus results in increased expression of MPZ protein CTD PMID:20739560 NCBI chr13:83,570,811...83,576,680
Ensembl chr13:83,570,811...83,576,679 		JBrowse link
G Msr1 macrophage scavenger receptor 1 decreases expression ISO Sirolimus results in decreased expression of MSR1 mRNA CTD PMID:17016853 NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676 		JBrowse link
G Mt1-ps3 metallothionein 1, pseudogene 3 multiple interactions ISO [(+)-JQ1 compound co-treated with Sirolimus] affects the expression of MT1E mRNA CTD PMID:25307878 NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
affects binding
increases phosphorylation
increases expression
decreases expression
decreases phosphorylation
decreases activity
increases activity		 ISO
EXP		 [Oxygen deficiency co-treated with Sirolimus] results in decreased expression of MTOR protein; [Sirolimus co-treated with Photosensitizing Agents] affects the phosphorylation of MTOR protein; [Sirolimus inhibits the reaction [MTOR protein binds to RPTOR protein]] which results in increased expression of MAP1LC3A protein alternative form; [Sirolimus results in decreased activity of [MTOR protein binds to RPTOR protein]] which results in increased activity of AR protein; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; [Sirolimus results in decreased activity of MTOR protein] which results in decreased expression of DDIT3 protein; [Sirolimus results in decreased activity of MTOR protein] which results in decreased expression of PKM protein; [Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of EIF4EBP1 protein; [Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein; [Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 protein; [Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of TP53 protein; [Sirolimus results in decreased activity of MTOR protein] which results in increased phosphorylation of GSK3B protein; [Sirolimus results in decreased activity of MTOR protein] which results in increased susceptibility to afimoxifene; [Sirolimus results in decreased activity of MTOR protein] which results in increased susceptibility to Fulvestrant; [Sirolimus results in decreased phosphorylation of MTOR protein] which results in decreased chemical synthesis of Reactive Oxygen Species; Curcumin promotes the reaction [Sirolimus results in decreased phosphorylation of MTOR protein]; MTOR protein inhibits the reaction [Sirolimus results in decreased activity of RPS6KB2 protein]; Sevoflurane promotes the reaction [Sirolimus results in decreased phosphorylation of MTOR protein]; Sirolimus affects the reaction [SLC31A1 protein affects the phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [3,4,5-tri-O-(E)-caffeoylquinic acid analog results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] affects the phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [[MTOR protein binds to RAPTOR protein] which binds to LARP1 protein]; Sirolimus inhibits the reaction [ATG4B protein results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [Ketoglutaric Acids results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [Oxygen deficiency results in increased expression of MTOR mRNA]; Sirolimus inhibits the reaction [Palmitic Acid results in increased activity of MTOR protein]; Sirolimus inhibits the reaction [puerarin results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [Serotonin results in increased activity of MTOR protein]; Sirolimus inhibits the reaction [sodium arsenite results in increased phosphorylation of MTOR protein]; Sirolimus promotes the reaction [Alpha-Amanitin results in decreased expression of and results in decreased phosphorylation of MTOR protein]; Sirolimus promotes the reaction [Cisplatin results in decreased phosphorylation of MTOR protein]; Sirolimus promotes the reaction [hydroquinone results in decreased phosphorylation of MTOR protein]; Sirolimus promotes the reaction [Sevoflurane results in decreased phosphorylation of MTOR protein]; Sirolimus results in decreased activity of [MTOR protein binds to RPTOR protein binds to MLST8 protein]; Sirolimus results in decreased activity of [MTOR protein binds to RPTOR protein]; Sirolimus results in decreased expression of and results in decreased phosphorylation of MTOR protein; Sirolimus results in decreased phosphorylation of and results in increased expression of MTOR protein; sodium arsenite promotes the reaction [Sirolimus results in decreased expression of MTOR protein]
Sirolimus binds to MTOR protein
Sirolimus results in increased phosphorylation of MTOR protein
Sirolimus results in increased expression of MTOR protein modified form
Sirolimus results in decreased expression of MTOR protein; Sirolimus results in decreased expression of MTOR protein modified form
[Silicon Dioxide co-treated with Sirolimus] results in decreased phosphorylation of MTOR protein; Sirolimus inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [2,2',3,5',6-pentachlorobiphenyl results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [dehydroacetic acid results in increased expression of and results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]]; Sirolimus inhibits the reaction [Paraquat results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [Roxarsone results in increased expression of and results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]]
Sirolimus results in increased expression of MTOR mRNA
Sirolimus results in increased activity of MTOR protein
[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol affects the susceptibility to Lipopolysaccharides]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CREB1 protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; [Sirolimus results in decreased activity of MTOR protein] which results in decreased susceptibility to Resveratrol; Sirolimus inhibits the reaction [[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [arsenite results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [Creatine results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [cyanoginosin LR results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [Dronabinol results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [Ketoglutaric Acids results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Poloxalene results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]]; Sirolimus inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of MTOR protein]; Sirolimus promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of MTOR protein]; Sirolimus promotes the reaction [cypermethrin results in decreased phosphorylation of MTOR protein]
Sirolimus results in decreased expression of MTOR mRNA; Sirolimus results in decreased expression of MTOR protein; Sirolimus results in decreased expression of MTOR protein modified form
[Sirolimus results in decreased activity of MTOR protein] which results in decreased activity of RPS6KB1 protein; Sirolimus results in decreased activity of MTOR protein		 CTD PMID:11602639 PMID:12087098 PMID:14673156 PMID:15050414 PMID:15782132 More... NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mturn maturin, neural progenitor differentiation regulator homolog multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of MTURN mRNA] CTD PMID:21245298 NCBI chr 4:83,807,528...83,828,494
Ensembl chr 4:83,807,579...83,824,950 		JBrowse link
G Mybl2 MYB proto-oncogene like 2 multiple interactions ISO [TGFB1 protein co-treated with Sirolimus] results in decreased expression of MYBL2 protein CTD PMID:12417722 NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [(+)-JQ1 compound co-treated with Sirolimus] results in decreased expression of MYC protein; [(+)-JQ1 compound co-treated with Sirolimus] results in increased expression of MYC mRNA; [Sirolimus co-treated with letrozole] results in decreased expression of MYC protein CTD PMID:20054642 PMID:25307878 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myf5 myogenic factor 5 decreases expression ISO Sirolimus results in decreased expression of MYF5 protein CTD PMID:30905858 NCBI chr 7:42,802,946...42,806,177
Ensembl chr 7:42,802,946...42,806,177 		JBrowse link
G Myh11 myosin heavy chain 11 multiple interactions
increases expression		 ISO [Sirolimus co-treated with IGF1 protein] results in increased expression of MYH11 protein; [Sirolimus results in increased activity of AKT2 protein] which results in increased expression of MYH11 protein
Sirolimus results in increased expression of MYH11 protein		 CTD PMID:17908691 NCBI chr10:743,364...838,459
Ensembl chr10:743,685...838,459 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Sirolimus inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA]] CTD PMID:25045214 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Mylk myosin light chain kinase multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of MYLK mRNA] CTD PMID:21245298 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Myod1 myogenic differentiation 1 affects expression ISO Sirolimus affects the expression of MYOD1 protein CTD PMID:30905858 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554 		JBrowse link
G Myof myoferlin multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of MYOF mRNA] CTD PMID:21245298 NCBI chr 1:235,673,666...235,822,413
Ensembl chr 1:235,673,666...235,822,334 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 decreases expression ISO Sirolimus results in decreased expression of NAIP mRNA CTD PMID:9836529 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Nanog Nanog homeobox increases expression ISO Sirolimus results in increased expression of NANOG mRNA CTD PMID:21681844 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
decreases expression		 EXP Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of NCF1 protein]
Sirolimus results in decreased expression of NCF1 protein		 CTD PMID:21195169 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 decreases expression
multiple interactions		 EXP Sirolimus results in decreased expression of NCF2 protein
Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of NCF2 protein]		 CTD PMID:21195169 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Ncf4 neutrophil cytosolic factor 4 multiple interactions EXP Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of NCF4 protein] CTD PMID:21195169 NCBI chr 7:109,825,420...109,843,389
Ensembl chr 7:109,826,020...109,843,389 		JBrowse link
G Ndc80 NDC80 kinetochore complex component multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of NDC80 mRNA CTD PMID:19016759 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924 		JBrowse link
G Nek2 NIMA-related kinase 2 multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of NEK2 mRNA CTD PMID:19016759 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases activity		 EXP
ISO		 NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]]; NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in increased expression of SNAI1 protein]]; NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in increased expression of VIM protein]]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of NFE2L2 mRNA]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein]
Sirolimus results in increased activity of NFE2L2 protein		 CTD PMID:28624451 PMID:30203046 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Sirolimus inhibits the reaction [Doxorubicin results in increased activity of NFKB1 protein] CTD PMID:15571967 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP		 Sirolimus inhibits the reaction [Doxorubicin results in increased degradation of and results in decreased expression of NFKBIA protein]; Sirolimus inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
Sirolimus inhibits the reaction [Isoproterenol results in increased degradation of NFKBIA protein]; Sirolimus inhibits the reaction [Pilocarpine results in increased phosphorylation of NFKBIA protein]
[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; Sirolimus inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]		 CTD PMID:15571967 PMID:18789402 PMID:22363816 PMID:23211629 PMID:25045214 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
decreases expression		 ISO
EXP		 Sirolimus inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]
Sirolimus inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]
Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]; Sirolimus inhibits the reaction [Particulate Matter results in increased expression of NLRP3 protein]; Sirolimus inhibits the reaction [Trichloroethylene results in increased expression of NLRP3 mRNA]
Sirolimus results in decreased expression of NLRP3 protein		 CTD PMID:30205151 PMID:32645460 PMID:35405287 PMID:36849104 PMID:37654027 More... NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of NME1 mRNA CTD PMID:19016759 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408 		JBrowse link
G Nmu neuromedin U multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of NMU mRNA] CTD PMID:21245298 NCBI chr14:31,844,564...31,872,196
Ensembl chr14:31,844,728...31,872,192 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
Sirolimus inhibits the reaction [Pilocarpine results in increased expression of NOS2 mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]		 CTD PMID:22363816 PMID:23211629 PMID:31499194 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases phosphorylation
decreases expression		 ISO Aspirin inhibits the reaction [Sirolimus results in decreased expression of NOS3 protein]; cilostazol inhibits the reaction [Sirolimus results in decreased expression of NOS3 protein]
Sirolimus results in increased phosphorylation of NOS3 protein
Sirolimus results in decreased expression of NOS3 mRNA; Sirolimus results in decreased expression of NOS3 protein		 CTD PMID:17261647 PMID:19520256 PMID:19815708 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Notch1 notch receptor 1 affects expression EXP Sirolimus affects the expression of NOTCH1 protein CTD PMID:26676567 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin affects expression EXP Sirolimus affects the expression of NPHS2 protein CTD PMID:19671594 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Sirolimus inhibits the reaction [rosiglitazone results in increased expression of NPPA mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]] CTD PMID:19397913 PMID:25045214 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]] CTD PMID:25045214 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 affects expression
increases expression		 ISO Sirolimus affects the expression of NR1H3 protein
Sirolimus increases expression of NR1H3 mRNA in macrophages		 CTD
RGD		 PMID:17016853 PMID:17016853 RGD:401827916 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in decreased expression of NR1H4 mRNA] CTD PMID:21245298 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases activity ISO Sirolimus results in increased activity of NR3C1 protein CTD PMID:15697228 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions ISO Sirolimus inhibits the reaction [Ethanol results in decreased expression of NR5A1 protein] CTD PMID:29524503 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328 		JBrowse link
G Nxt1 nuclear transport factor 2-like export factor 1 decreases expression ISO Sirolimus results in decreased expression of NXT1 mRNA CTD PMID:11355896 NCBI chr 3:136,108,975...136,111,897
Ensembl chr 3:136,108,862...136,111,907 		JBrowse link
G Ogn osteoglycin increases expression EXP Sirolimus results in increased expression of OGN mRNA CTD PMID:21865292 NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 affects expression ISO Sirolimus affects the expression of OLR1 protein CTD PMID:17016853 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523 		JBrowse link
G Optn optineurin multiple interactions ISO Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of OPTN protein] CTD PMID:25884947 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251 		JBrowse link
G Otud7b OTU deubiquitinase 7B multiple interactions ISO
EXP		 Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in decreased expression of SQSTM1 protein]]; Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in increased expression of ATG5 protein]]
Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in decreased expression of SQSTM1 protein]]; Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]]; Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in increased expression of ATG5 protein]]		 CTD PMID:36639017 NCBI chr 2:183,661,955...183,722,584
Ensembl chr 2:183,662,163...183,718,674 		JBrowse link
G Oxa1l OXA1L, mitochondrial inner membrane protein multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of OXA1L mRNA] CTD PMID:21245298 NCBI chr15:27,813,688...27,821,319
Ensembl chr15:27,813,625...27,821,319 		JBrowse link
G Pabpc1 poly(A) binding protein, cytoplasmic 1 multiple interactions
decreases expression		 ISO Sirolimus inhibits the reaction [EIF4G1 protein binds to PABPC1 mRNA]; Sirolimus promotes the reaction [LARP1 protein binds to PABPC1 mRNA]
Sirolimus results in decreased expression of PABPC1 protein		 CTD PMID:25940091 NCBI chr 7:67,777,438...67,789,731
Ensembl chr 7:67,777,381...67,789,744 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
increases expression		 ISO
EXP		 [Sirolimus co-treated with ovatodiolide] results in increased cleavage of PARP1 protein; ATG5 protein affects the reaction [Sirolimus inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]]; MCL1 protein inhibits the reaction [Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]; Sirolimus inhibits the reaction [Ethanol results in increased cleavage of PARP1 protein]; Sirolimus inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [ovatodiolide results in increased cleavage of PARP1 protein]
Sirolimus results in increased cleavage of PARP1 protein
Sirolimus results in increased expression of PARP1 protein modified form
[Sirolimus co-treated with Resveratrol] results in increased cleavage of PARP1 protein; Sirolimus inhibits the reaction [Methamphetamine results in increased cleavage of PARP1 protein]; TSC2 protein inhibits the reaction [[Sirolimus co-treated with Resveratrol] results in increased cleavage of PARP1 protein]
Sirolimus promotes the reaction [Cadmium results in increased cleavage of PARP1 protein]		 CTD PMID:19682553 PMID:21410490 PMID:24304514 PMID:25307878 PMID:26825372 More... NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pax8 paired box 8 multiple interactions ISO Sirolimus promotes the reaction [TP73 protein affects the activity of PAX8 protein] CTD PMID:21245298 NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP [troglitazone co-treated with Sirolimus] results in decreased expression of PCK1 mRNA CTD PMID:10446394 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression		 ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of PCNA mRNA
Sirolimus inhibits the reaction [IL2 protein results in increased expression of PCNA mRNA]
Sirolimus results in decreased expression of PCNA protein		 CTD PMID:9151781 PMID:11355896 PMID:19016759 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdcd4 programmed cell death 4 multiple interactions
increases stability
increases expression		 ISO
EXP		 [resveratrol co-treated with Sirolimus] results in increased stability of PDCD4 protein; Sirolimus promotes the reaction [Tretinoin results in increased expression of PDCD4 protein]
Sirolimus results in increased stability of PDCD4 protein
resveratrol inhibits the reaction [Sirolimus results in increased stability of PDCD4 protein]
[Sirolimus co-treated with resveratrol] results in increased stability of PDCD4 protein; PDCD4 mutant form inhibits the reaction [Sirolimus inhibits the reaction [Pasteurella multocida toxin results in increased expression of CTSK mRNA]]; Sirolimus inhibits the reaction [Pasteurella multocida toxin results in decreased expression of PDCD4 mRNA]; Sirolimus inhibits the reaction [Pasteurella multocida toxin results in decreased expression of PDCD4 protein]; TSC2 gene mutant form promotes the reaction [[Sirolimus co-treated with resveratrol] results in increased stability of PDCD4 protein]
Sirolimus results in increased expression of PDCD4 protein
Sirolimus results in increased expression of PDCD4 mRNA; Sirolimus results in increased expression of PDCD4 protein		 CTD PMID:17259349 PMID:24304514 PMID:24356939 PMID:26369790 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Sirolimus inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:15919668 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases response to substance
multiple interactions
increases expression
increases activity		 ISO Sirolimus results in decreased susceptibility to PIK3CA protein
Sirolimus inhibits the reaction [TGFB1 protein results in increased expression of PIK3CA mRNA]
Sirolimus results in increased expression of PIK3CA mRNA
Sirolimus results in increased activity of PIK3CA protein
Sirolimus inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; Sirolimus inhibits the reaction [PIK3CA protein modified form results in decreased expression of CXCL8 mRNA]; Sirolimus inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]; Sirolimus inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]; Sirolimus inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA]; Wortmannin inhibits the reaction [Sirolimus results in increased activity of PIK3CA protein]		 CTD PMID:10373522 PMID:16227402 PMID:27542212 PMID:31522336 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta multiple interactions
increases expression		 ISO Sirolimus inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA]
Sirolimus results in increased expression of PIK3CB mRNA		 CTD PMID:31522336 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta increases expression
multiple interactions		 ISO Sirolimus results in increased expression of PIK3CD mRNA
Sirolimus inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CD mRNA]		 CTD PMID:31522336 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma multiple interactions
decreases expression		 ISO Sirolimus inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CG mRNA]
Sirolimus results in decreased expression of PIK3CG mRNA		 CTD PMID:31522336 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO Sirolimus promotes the reaction [IRS1 protein binds to PIK3R1 protein] CTD PMID:17908691 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase multiple interactions ISO [(+)-JQ1 compound co-treated with Sirolimus] affects the expression of PIM1 mRNA CTD PMID:25307878 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO
EXP		 Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of PINK1 protein]; Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of PINK1 protein] CTD PMID:33823232 PMID:35405287 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions
increases expression		 ISO [Sirolimus results in decreased activity of MTOR protein] which results in decreased expression of PKM protein; Curcumin inhibits the reaction [Sirolimus results in increased expression of PKM protein]; Sirolimus inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PKM protein] CTD PMID:22574221 PMID:36336208 PMID:36640941 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pkp4 plakophilin 4 increases expression EXP Sirolimus results in increased expression of PKP4 mRNA CTD PMID:21865292 NCBI chr 3:43,632,364...43,835,834
Ensembl chr 3:43,631,880...43,835,474 		JBrowse link
G Plcl1 phospholipase C-like 1 increases expression ISO Sirolimus results in increased expression of PLCL1 mRNA CTD PMID:24356939 NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO [[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein CTD PMID:20686837 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pml PML nuclear body scaffold increases expression
increases localization
decreases response to substance		 ISO Sirolimus results in increased expression of PML protein
Sirolimus results in increased localization of PML protein
PML protein results in decreased susceptibility to Sirolimus		 CTD PMID:23440206 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Pmp22 peripheral myelin protein 22 increases metabolic processing ISO Sirolimus results in increased metabolism of PMP22 protein mutant form CTD PMID:20739560 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression ISO Sirolimus results in increased expression of PNPLA2 mRNA; Sirolimus results in increased expression of PNPLA2 protein CTD PMID:20068142 NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805 		JBrowse link
G Pnrc1 proline-rich nuclear receptor coactivator 1 increases expression ISO Sirolimus results in increased expression of PNRC1 mRNA CTD PMID:24356939 NCBI chr 5:47,647,070...47,657,832
Ensembl chr 5:47,647,071...47,650,161 		JBrowse link
G Pold2 DNA polymerase delta 2, accessory subunit decreases expression ISO Sirolimus results in decreased expression of POLD2 mRNA CTD PMID:11355896 NCBI chr14:80,748,971...80,755,188
Ensembl chr14:80,748,974...80,755,160 		JBrowse link
G Polr1h RNA polymerase I subunit H multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of POLR1H mRNA] CTD PMID:21245298 NCBI chr20:1,594,936...1,598,854
Ensembl chr20:1,594,936...1,598,854 		JBrowse link
G Postn periostin multiple interactions EXP Sirolimus inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA] CTD PMID:15121739 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression ISO Sirolimus results in increased expression of POU5F1 mRNA; Sirolimus results in increased expression of POU5F1 protein CTD PMID:21681844 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARA mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARA protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARA mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARA protein]] CTD PMID:25045214 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO PPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of ERN1 protein]; PPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of HSPA5 protein] CTD PMID:24898257 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
multiple interactions
decreases expression		 ISO Sirolimus affects the expression of PPARG protein
Sirolimus inhibits the reaction [Endrin results in increased expression of PPARG mRNA]
Sirolimus results in decreased expression of PPARG mRNA
[Sirolimus co-treated with Cyclosporine] results in decreased expression of PPARG protein; [Sirolimus co-treated with Tacrolimus] results in increased expression of PPARG protein		 CTD PMID:15358118 PMID:17016853 PMID:34801515 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP
ISO		 Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A protein]]
Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of PPARGC1A mRNA]		 CTD PMID:25045214 PMID:31499194 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppl periplakin increases expression EXP Sirolimus results in increased expression of PPL mRNA CTD PMID:21865292 NCBI chr10:10,450,919...10,496,575
Ensembl chr10:10,450,919...10,496,575 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO Sirolimus inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]; Sirolimus inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein] CTD PMID:17209049 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta multiple interactions ISO Sirolimus inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA] CTD PMID:27542212 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485 		JBrowse link
G Prcp prolylcarboxypeptidase increases expression EXP Sirolimus results in increased expression of PRCP mRNA CTD PMID:21865292 NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530 		JBrowse link
G Prf1 perforin 1 decreases expression ISO Sirolimus results in decreased expression of PRF1 protein CTD PMID:16477233 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP Sirolimus inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein] CTD PMID:21195169 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Sirolimus inhibits the reaction [Estradiol results in increased phosphorylation of PRKCA protein] CTD PMID:23000059 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcd protein kinase C, delta affects localization
multiple interactions
decreases phosphorylation		 ISO Sirolimus affects the localization of PRKCD protein
sodium arsenite promotes the reaction [Sirolimus results in decreased phosphorylation of PRKCD protein]		 CTD PMID:20082316 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkcg protein kinase C, gamma increases degradation
multiple interactions		 ISO Sirolimus results in increased degradation of PRKCG protein mutant form
Sirolimus inhibits the reaction [PRKCG protein mutant form binds to PRKCG protein mutant form]		 CTD PMID:20398063 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Prkch protein kinase C, eta decreases response to substance
multiple interactions		 ISO PRKCH results in decreased susceptibility to Sirolimus
[Tetradecanoylphorbol Acetate results in increased activity of PRKCH protein] inhibits the reaction [Sirolimus results in decreased phosphorylation of RPS6 protein]		 CTD PMID:16832347 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654 		JBrowse link
G Prkd2 protein kinase D2 multiple interactions ISO PRKD2 protein affects the reaction [Sirolimus results in increased lipidation of MAP1LC3B protein] CTD PMID:37951334 NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP
ISO		 Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of PRKN protein]
Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of PRKN protein]; Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of PRKN protein]		 CTD PMID:33823232 PMID:35405287 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Prlr prolactin receptor decreases expression EXP Sirolimus results in decreased expression of PRLR mRNA CTD PMID:21865292 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718 		JBrowse link
G Prmt5 protein arginine methyltransferase 5 increases activity ISO Sirolimus results in increased activity of PRMT5 protein CTD PMID:31473880 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296 		JBrowse link
G Psma1 proteasome 20S subunit alpha 1 decreases expression ISO Sirolimus results in decreased expression of PSMA1 mRNA CTD PMID:11355896 NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472 		JBrowse link
G Psma4 proteasome 20S subunit alpha 4 decreases expression ISO Sirolimus results in decreased expression of PSMA4 mRNA CTD PMID:11355896 NCBI chr 8:55,340,431...55,347,893
Ensembl chr 8:55,340,386...55,347,890 		JBrowse link
G Psmd11 proteasome 26S subunit, non-ATPase 11 decreases expression ISO Sirolimus results in decreased expression of PSMD11 mRNA; Sirolimus results in decreased expression of PSMD11 protein CTD PMID:15782132 NCBI chr10:65,433,853...65,479,774
Ensembl chr10:65,433,853...65,479,766 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
decreases expression
decreases response to substance		 ISO
EXP		 [Decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of PTEN mRNA; Sirolimus inhibits the reaction [TNF protein results in decreased expression of PTEN protein]
Sirolimus inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein]
Sirolimus results in decreased expression of PTEN protein
PTEN protein results in decreased susceptibility to Sirolimus		 CTD PMID:18303120 PMID:18622747 PMID:19625624 PMID:21195169 PMID:31676321 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptger1 prostaglandin E receptor 1 multiple interactions ISO Sirolimus inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein] CTD PMID:20335389 NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
affects expression		 ISO
EXP		 [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; Sirolimus inhibits the reaction [cyanoginosin LR results in increased expression of PTGS2 protein]
Sirolimus affects the expression of PTGS2 mRNA
Sirolimus inhibits the reaction [Pilocarpine results in increased expression of PTGS2 mRNA]; Sirolimus inhibits the reaction [Pilocarpine results in increased expression of PTGS2 protein]		 CTD PMID:22363816 PMID:23211629 PMID:24971338 PMID:36115647 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO Sirolimus results in decreased phosphorylation of PTK2 protein CTD PMID:19922502 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 multiple interactions EXP Sirolimus inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein] CTD PMID:17623046 NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C increases expression ISO Sirolimus results in increased expression of PTPRC mRNA CTD PMID:11355896 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of PTTG1 mRNA CTD PMID:19016759 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Sirolimus inhibits the reaction [Trichloroethylene results in increased expression of PYCARD mRNA] CTD PMID:36849104 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression
multiple interactions		 EXP Sirolimus results in decreased expression of RAC1 protein
Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of RAC1 protein]		 CTD PMID:21195169 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of RAD51 mRNA CTD PMID:19016759 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of RAF1 protein CTD PMID:15767555 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases phosphorylation		 ISO
EXP		 [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased phosphorylation of RB1 protein]; [Sirolimus co-treated with Letrozole] results in decreased expression of RB1 protein; [Sirolimus co-treated with TGFB1 protein] results in decreased phosphorylation of RB1 protein; [tanespimycin co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein; [TGFB1 protein co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein; Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RB1 protein]
Sirolimus results in decreased phosphorylation of RB1 protein
[Sirolimus co-treated with TGFB1 protein] results in decreased phosphorylation of RB1 protein; [TGFB1 protein co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein; Sirolimus inhibits the reaction [KITL protein results in increased phosphorylation of RB1 protein]		 CTD PMID:7532117 PMID:8419408 PMID:10373522 PMID:10849422 PMID:12393642 More... NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 multiple interactions ISO [TGFB1 protein co-treated with Sirolimus] inhibits the reaction [[E2F4 protein binds to RBL1 protein] which binds to CDK2 protein] CTD PMID:12417722 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions ISO [TGFB1 protein co-treated with Sirolimus] inhibits the reaction [[E2F4 protein binds to RBL2 protein] which binds to CDK2 protein]; Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RBL2 protein] CTD PMID:10373522 PMID:12417722 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572 		JBrowse link
G Rcan1 regulator of calcineurin 1 multiple interactions ISO [(+)-JQ1 compound co-treated with Sirolimus] affects the expression of RCAN1 mRNA CTD PMID:25307878 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 Sirolimus inhibits the reaction [3,4,5-tri-O-(E)-caffeoylquinic acid analog results in increased phosphorylation of RELA protein]; Sirolimus inhibits the reaction [Doxorubicin results in increased activity of RELA protein]; Sirolimus inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Sirolimus inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; Sirolimus inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
Sirolimus inhibits the reaction [Isoproterenol affects the localization of RELA protein]; Sirolimus inhibits the reaction [Zearalenone results in increased phosphorylation of and affects the localization of RELA protein]
[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]; Sirolimus inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]		 CTD PMID:15571967 PMID:18789402 PMID:22003094 PMID:22363816 PMID:25045214 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin increases expression EXP Sirolimus results in increased expression of REN mRNA CTD PMID:21865292 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Rest RE1-silencing transcription factor multiple interactions ISO Sirolimus promotes the reaction [TP73 protein affects the activity of REST protein] CTD PMID:21245298 NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354 		JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 decreases expression ISO Sirolimus results in decreased expression of RICTOR protein CTD PMID:18776922 NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426 		JBrowse link
G Rpl32 ribosomal protein L32 multiple interactions
decreases expression		 ISO LARP1 protein promotes the reaction [Sirolimus results in decreased expression of RPL32 protein]; Sirolimus inhibits the reaction [EIF4G1 protein binds to RPL32 mRNA]; Sirolimus promotes the reaction [LARP1 protein binds to RPL32 mRNA] CTD PMID:25940091 NCBI chr 4:148,864,048...148,867,612
Ensembl chr 4:148,864,044...148,867,612 		JBrowse link
G Rps20 ribosomal protein S20 multiple interactions
decreases expression		 ISO LARP1 protein promotes the reaction [Sirolimus results in decreased expression of RPS20 protein]; Sirolimus inhibits the reaction [EIF4G1 protein binds to RPS20 mRNA]; Sirolimus promotes the reaction [LARP1 protein binds to RPS20 mRNA] CTD PMID:25940091 NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475 		JBrowse link
G Rps27l ribosomal protein S27-like multiple interactions ISO Sirolimus promotes the reaction [TP73 protein binds to RPS27L promoter] CTD PMID:21245298 NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases phosphorylation
increases phosphorylation
decreases expression		 ISO
EXP		 [Resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein; [Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein; [Tetradecanoylphorbol Acetate results in increased activity of PRKCH protein] inhibits the reaction [Sirolimus results in decreased phosphorylation of RPS6 protein]; LARP1 protein promotes the reaction [Sirolimus results in decreased expression of RPS6 protein]; Sirolimus inhibits the reaction [CXCL8 protein results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [EIF4G1 protein binds to RPS6 mRNA]; Sirolimus inhibits the reaction [HRAS protein mutant form results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [INS protein results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [Ketoglutaric Acids results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [Testosterone results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6 protein]; Sirolimus promotes the reaction [LARP1 protein binds to RPS6 mRNA]; TSC2 gene mutant form promotes the reaction [[Resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein]; TSC2 gene mutant form promotes the reaction [Sirolimus results in decreased phosphorylation of RPS6 protein]
[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein
Sirolimus results in increased phosphorylation of RPS6 protein
[Resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein; Sirolimus inhibits the reaction [[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [arsenite results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [CSF1 protein results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [Dronabinol results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [Ketoglutaric Acids results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RPS6 protein]; Tacrolimus inhibits the reaction [Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]]		 CTD PMID:1614535 PMID:10373522 PMID:12939469 PMID:14502240 PMID:15297429 More... NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 increases phosphorylation
multiple interactions
affects localization		 ISO
EXP		 Sirolimus results in increased phosphorylation of RPS6KA1 protein
Sirolimus results in increased phosphorylation of and results in increased activity of RPS6KA1 protein
Sirolimus affects the localization of RPS6KA1 protein		 CTD PMID:19151764 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 affects localization
increases phosphorylation		 ISO Sirolimus affects the localization of RPS6KA2 protein
Sirolimus results in increased phosphorylation of RPS6KA2 protein		 CTD PMID:19151764 NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 affects localization
increases phosphorylation		 ISO Sirolimus affects the localization of RPS6KA3 protein
Sirolimus results in increased phosphorylation of RPS6KA3 protein		 CTD PMID:19151764 NCBI chr  X:35,517,306...35,623,296
Ensembl chr  X:35,517,306...35,623,207 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases expression
decreases phosphorylation
increases phosphorylation
decreases expression
decreases activity		 ISO
EXP		 [Dexamethasone co-treated with Sirolimus] inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]; [Dexamethasone co-treated with Sirolimus] inhibits the reaction [IL6 protein results in increased phosphorylation of RPS6KB1 protein]; [Resveratrol co-treated with Sirolimus] results in increased phosphorylation of RPS6KB1 protein; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of RPS6KB1 protein; [Sirolimus co-treated with Oxygen deficiency] results in decreased phosphorylation of RPS6KB1 protein; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; [Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 protein; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased abundance of Nitric Oxide; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased activity of IRS1 protein; Sirolimus inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] affects the phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Acetaldehyde results in increased activity of RPS6KB1 protein]; Sirolimus inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Sirolimus inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [cyanoginosin LR promotes the reaction [INS protein results in increased expression of RPS6KB1 protein modified form]]; Sirolimus inhibits the reaction [cyanoginosin LR results in increased expression of RPS6KB1 protein modified form]; Sirolimus inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [INS protein promotes the reaction [cyanoginosin LR results in increased expression of RPS6KB1 protein modified form]]; Sirolimus inhibits the reaction [INS protein results in increased expression of RPS6KB1 protein modified form]; Sirolimus inhibits the reaction [Ketoglutaric Acids results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Orotic Acid results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Sirolimus inhibits the reaction [puerarin results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Testosterone results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]; Sirolimus promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased phosphorylation of RPS6KB1 protein]; Sirolimus promotes the reaction [sodium arsenite results in decreased phosphorylation of RPS6KB1 protein]; Sirolimus results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein; sodium arsenite promotes the reaction [Sirolimus results in decreased phosphorylation of RPS6KB1 protein]
Sirolimus results in increased expression of RPS6KB1 protein modified form
Sirolimus results in increased phosphorylation of RPS6KB1 protein
Sirolimus results in decreased expression of RPS6KB1 protein modified form
Sirolimus results in decreased phosphorylation of RPS6KB1 protein; Sirolimus results in decreased phosphorylation of S6K protein
[[manganese chloride results in increased abundance of Manganese] which co-treated with Sirolimus] results in decreased phosphorylation of RPS6KB1 protein; [Sirolimus co-treated with Resveratrol] inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of RPS6KB1 protein]; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BAX mRNA; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BAX protein; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BID mRNA; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BID protein; MRK 003 promotes the reaction [Sirolimus results in decreased activity of RPS6KB1 protein]; Sirolimus inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Sirolimus inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Dronabinol results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Glucose results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [INS1 protein results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Ketoglutaric Acids results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Pasteurella multocida toxin results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Propranolol results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [TSC1 gene mutant form results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of RPS6KB1 protein modified form]; Sirolimus promotes the reaction [MRK 003 results in decreased activity of RPS6KB1 protein]; Sirolimus promotes the reaction [Resveratrol results in decreased phosphorylation of RPS6KB1 protein]
[Sirolimus co-treated with Resveratrol] results in decreased phosphorylation of RPS6KB1 protein; Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Cadmium results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]; Sirolimus inhibits the reaction [INS1 protein results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; Sirolimus inhibits the reaction [Resveratrol inhibits the reaction [TSC2 protein results in decreased phosphorylation of RPS6KB1 protein]]; Sirolimus inhibits the reaction [Roxarsone results in increased expression of and results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Sertraline results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Sirolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]; Sirolimus results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein
[Sirolimus results in decreased activity of MTOR protein] which results in decreased activity of RPS6KB1 protein; Sirolimus results in decreased activity of RPS6KB1 protein		 CTD PMID:12411397 PMID:14516795 PMID:14673156 PMID:15070696 PMID:15297429 More... NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions
decreases activity		 ISO MTOR protein inhibits the reaction [Sirolimus results in decreased activity of RPS6KB2 protein]; Sirolimus inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein] CTD PMID:12087098 NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 multiple interactions ISO [Sirolimus inhibits the reaction [MTOR protein binds to RPTOR protein]] which results in increased expression of MAP1LC3A protein alternative form; [Sirolimus results in decreased activity of [MTOR protein binds to RPTOR protein]] which results in increased activity of AR protein; RPTOR protein inhibits the reaction [Sirolimus results in increased activity of AR protein]; Sirolimus inhibits the reaction [[MTOR protein binds to RAPTOR protein] which binds to LARP1 protein]; Sirolimus inhibits the reaction [Orotic Acid results in decreased phosphorylation of RPTOR protein]; Sirolimus results in decreased activity of [MTOR protein binds to RPTOR protein binds to MLST8 protein]; Sirolimus results in decreased activity of [MTOR protein binds to RPTOR protein] CTD PMID:18776922 PMID:19505958 PMID:21742779 PMID:22863860 PMID:25940091 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983 		JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator multiple interactions ISO Sirolimus promotes the reaction [TP73 protein binds to RRAD promoter] CTD PMID:21245298 NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417 		JBrowse link
G Rtn4 reticulon 4 multiple interactions EXP Sirolimus inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of RTN4 protein] CTD PMID:26648565 NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686 		JBrowse link
G Rtn4r reticulon 4 receptor multiple interactions EXP Sirolimus inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of RTN4R protein] CTD PMID:26648565 NCBI chr11:82,844,309...82,869,251
Ensembl chr11:82,844,309...82,869,466 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO Sirolimus inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 mRNA]
Sirolimus inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]]; Sirolimus inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]]		 CTD PMID:23111315 PMID:33450223 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression EXP Sirolimus results in decreased expression of S100A4 mRNA CTD PMID:21865292 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G S100g S100 calcium binding protein G increases expression EXP Sirolimus results in increased expression of S100G mRNA CTD PMID:21865292 NCBI chr  X:31,705,853...31,708,422
Ensembl chr  X:31,705,866...31,708,433 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 increases expression ISO Sirolimus results in increased expression of S1PR1 mRNA CTD PMID:24356939 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G Scarb2 scavenger receptor class B, member 2 decreases expression ISO Sirolimus results in decreased expression of SCARB2 mRNA CTD PMID:17016853 NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in decreased expression of SCD mRNA] CTD PMID:21245298 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sema3a semaphorin 3A multiple interactions ISO
EXP		 Sirolimus inhibits the reaction [chromium hexavalent ion results in increased expression of SEMA3A protein] CTD PMID:30236763 NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432 		JBrowse link
G Sema3c semaphorin 3C multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of SEMA3C mRNA] CTD PMID:21245298 NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534 		JBrowse link
G Serpina1 serpin family A member 1 affects localization ISO Sirolimus affects the localization of SERPINA1 protein CTD PMID:20511674 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339 		JBrowse link
G Serpina3n serpin family A member 3N increases expression EXP Sirolimus results in increased expression of SERPINA3N mRNA CTD PMID:21865292 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in decreased expression of SERPINE1 mRNA]
Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]]		 CTD PMID:21245298 PMID:31499194 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO [(+)-JQ1 compound co-treated with Sirolimus] affects the expression of SESN2 mRNA CTD PMID:25307878 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions ISO Sirolimus inhibits the reaction [phenanthrene results in decreased expression of SHANK3 mRNA] CTD PMID:34453960 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
G Shisa2 shisa family member 2 increases expression ISO Sirolimus results in increased expression of SHISA2 mRNA CTD PMID:24356939 NCBI chr15:33,806,715...33,811,013
Ensembl chr15:33,805,958...33,811,013 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases response to substance
increases expression
decreases expression		 ISO
EXP		 [(+)-JQ1 compound co-treated with Sirolimus] results in decreased expression of SIRT1 protein; Aspirin inhibits the reaction [Sirolimus results in decreased expression of SIRT1 protein]; cilostazol inhibits the reaction [Sirolimus results in decreased expression of SIRT1 protein]
SIRT1 protein results in increased susceptibility to Sirolimus
Sirolimus results in increased expression of SIRT1 protein
Sirolimus inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]; SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]; SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of GLB1 protein]]		 CTD PMID:19520256 PMID:22561310 PMID:25307878 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of SIRT2 mRNA] CTD PMID:21245298 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt4 sirtuin 4 multiple interactions ISO
EXP		 Sirolimus affects the reaction [SIRT4 protein affects the reaction [Doxorubicin affects the expression of SQSTM1 protein]]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased expression of BECN1 protein]]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased lipidation of MAP1LC3B protein]]
Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased expression of SQSTM1 protein]]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased expression of BECN1 protein]]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased lipidation of MAP1LC3B protein]]		 CTD PMID:35134463 NCBI chr12:41,125,533...41,139,440
Ensembl chr12:41,131,262...41,139,439 		JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO Sirolimus results in decreased expression of SKP2 protein CTD PMID:21092744 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Slc12a1 solute carrier family 12 member 1 multiple interactions
decreases expression		 EXP rosiglitazone inhibits the reaction [Sirolimus results in decreased expression of SLC12A1 protein] CTD PMID:19656910 NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 increases expression EXP Sirolimus results in increased expression of SLC12A3 mRNA CTD PMID:21865292 NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Sirolimus inhibits the reaction [rosiglitazone results in increased expression of and results in increased activity of SLC15A1 protein] CTD PMID:22108913 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 decreases expression EXP Sirolimus results in decreased expression of SLC16A1 mRNA CTD PMID:21865292 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc22a13 solute carrier family 22 member 13 decreases expression EXP Sirolimus results in decreased expression of SLC22A13 mRNA CTD PMID:21865292 NCBI chr 8:118,922,367...118,934,020
Ensembl chr 8:118,922,367...118,953,635 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO Sirolimus inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC2A1 protein]; Sirolimus inhibits the reaction [ATG4B protein results in increased expression of SLC2A1 protein] CTD PMID:36336208 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO Sirolimus affects the reaction [SLC31A1 protein affects the expression of BAX protein]; Sirolimus affects the reaction [SLC31A1 protein affects the expression of BCL2 protein]; Sirolimus affects the reaction [SLC31A1 protein affects the phosphorylation of AKT1 protein]; Sirolimus affects the reaction [SLC31A1 protein affects the phosphorylation of MTOR protein] CTD PMID:37290678 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228 		JBrowse link
G Slc5a1 solute carrier family 5 member 1 decreases expression EXP Sirolimus results in decreased expression of SLC5A1 mRNA CTD PMID:21865292 NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547 		JBrowse link
G Slc7a12 solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 increases expression EXP Sirolimus results in increased expression of SLC7A12 mRNA CTD PMID:21865292 NCBI chr 2:87,079,724...87,146,875
Ensembl chr 2:87,079,749...87,146,875 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression EXP Sirolimus results in increased expression of SLCO1A4 mRNA CTD PMID:11589784 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Smim14 small integral membrane protein 14 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of SMIM14 mRNA] CTD PMID:21245298 NCBI chr14:42,783,361...42,829,762
Ensembl chr14:42,783,332...42,829,760 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions
increases expression		 ISO
EXP		 Sirolimus inhibits the reaction [sodium arsenite results in increased expression of SNAI1 mRNA]
NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in increased expression of SNAI1 protein]]; Sirolimus inhibits the reaction [Paraquat results in increased expression of SNAI1 mRNA]; Sirolimus inhibits the reaction [Paraquat results in increased expression of SNAI1 protein]; Sirolimus promotes the reaction [Dibutyl Phthalate results in increased expression of SNAI1 mRNA]
Sirolimus results in increased expression of SNAI1 protein		 CTD PMID:28624451 PMID:28888487 PMID:30053495 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snca synuclein alpha multiple interactions ISO Sirolimus inhibits the reaction [Paraquat results in increased expression of SNCA protein] CTD PMID:32306690 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Sirolimus inhibits the reaction [sodium arsenite results in decreased expression of SOD1 protein] CTD PMID:38574842 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO Sirolimus results in decreased expression of SOD2 protein CTD PMID:30905858 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO Sirolimus results in increased expression of SOX2 mRNA CTD PMID:21681844 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression ISO Sirolimus results in decreased expression of SOX9 protein CTD PMID:34536393 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO Sirolimus inhibits the reaction [Ketoglutaric Acids results in increased expression of SPP1 protein] CTD PMID:31051157 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases degradation
increases expression
decreases expression		 ISO
EXP		 [Sirolimus co-treated with Cadmium] results in decreased expression of SQSTM1 protein; [Sirolimus co-treated with gelsenicine] results in decreased expression of SQSTM1 protein; bafilomycin A1 inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; CD38 mutant form inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; Niacinamide inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; Resveratrol inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; Sirolimus affects the reaction [SIRT4 protein affects the reaction [Doxorubicin affects the expression of SQSTM1 protein]]; Sirolimus inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in decreased expression of SQSTM1 protein]]; Sirolimus inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of SQSTM1 protein]; Sirolimus promotes the reaction [Alpha-Amanitin results in decreased expression of SQSTM1 protein]; Sirolimus promotes the reaction [Ethanol results in decreased expression of SQSTM1 protein]
Sirolimus results in increased degradation of SQSTM1 protein
Sirolimus results in increased expression of SQSTM1 protein
[AICA ribonucleotide co-treated with Sirolimus] results in increased expression of SQSTM1 protein; [Sirolimus co-treated with TNF protein] results in decreased expression of SQSTM1 protein; Curcumin inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; Resveratrol inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [honokiol results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [lead acetate results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [ovatodiolide results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of SQSTM1 protein]; Sirolimus promotes the reaction [2,4,4'-trichlorobiphenyl results in increased expression of SQSTM1 protein]; Sirolimus promotes the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of SQSTM1 protein]; Sirolimus promotes the reaction [Dexamethasone results in decreased expression of SQSTM1 protein]; Sirolimus promotes the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased degradation of SQSTM1 protein]
[Sirolimus co-treated with cadmium acetate] results in decreased expression of SQSTM1 mRNA; Sirolimus inhibits the reaction [Epirubicin results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [manganese chloride results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in decreased expression of SQSTM1 protein]]; Sirolimus inhibits the reaction [Particulate Matter results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased expression of SQSTM1 protein]]; Sirolimus promotes the reaction [2,4,4'-trichlorobiphenyl results in increased expression of SQSTM1 protein]; Sirolimus promotes the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of SQSTM1 protein]; Sirolimus promotes the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in increased expression of SQSTM1 protein]]		 CTD PMID:19773376 PMID:24238063 PMID:24304514 PMID:25884947 PMID:28025121 More... NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO [Sirolimus results in increased phosphorylation of and results in increased activity of SRC protein] which results in increased phosphorylation of EGFR protein; [Sirolimus results in increased phosphorylation of and results in increased activity of SRC protein] which results in increased phosphorylation of MAPK1 protein; [Sirolimus results in increased phosphorylation of and results in increased activity of SRC protein] which results in increased phosphorylation of MAPK3 protein; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in decreased phosphorylation of SRC protein]; Sirolimus results in increased phosphorylation of and results in increased activity of SRC protein CTD PMID:19151764 PMID:31499194 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO Sirolimus results in decreased expression of SREBF1 mRNA CTD PMID:15358118 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srr serine racemase multiple interactions ISO Sirolimus inhibits the reaction [methyllycaconitine results in increased expression of SRR protein] CTD PMID:24012499 NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Sirolimus inhibits the reaction [Polystyrenes analog results in decreased expression of STAR protein] CTD PMID:36709824 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stard10 StAR-related lipid transfer domain containing 10 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of STARD10 mRNA] CTD PMID:21245298 NCBI chr 1:155,722,637...155,748,007
Ensembl chr 1:155,718,389...155,747,094 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions		 ISO
EXP		 Sirolimus results in decreased phosphorylation of STAT3 protein
Sirolimus inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of STAT3 protein]
Sirolimus inhibits the reaction [IFNG protein results in decreased phosphorylation of STAT3 protein]		 CTD PMID:16391472 PMID:16427044 PMID:20038814 PMID:26648565 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sts steroid sulfatase multiple interactions ISO Sirolimus inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase multiple interactions ISO [TNF protein co-treated with Sirolimus co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein; [TNF protein co-treated with Sirolimus] results in decreased expression of SUV39H1 protein CTD PMID:31676321 NCBI chr  X:14,421,028...14,433,993
Ensembl chr  X:14,421,109...14,433,982 		JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 multiple interactions ISO [TNF protein co-treated with Sirolimus co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein; [TNF protein co-treated with Sirolimus] results in decreased expression of SUV39H1 protein CTD PMID:31676321 NCBI chr  X:141,792,589...141,795,257 JBrowse link
G Syn1 synapsin I multiple interactions ISO Sirolimus inhibits the reaction [Ketamine results in increased expression of SYN1 protein] CTD PMID:33022268 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396 		JBrowse link
G Syt1 synaptotagmin 1 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of SYT1 mRNA] CTD PMID:21245298 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803 		JBrowse link
G Taf12 TATA-box binding protein associated factor 12 decreases expression ISO Sirolimus results in decreased expression of TAF12 mRNA CTD PMID:11355896 NCBI chr 5:144,472,816...144,490,299
Ensembl chr 5:144,472,841...144,488,849 		JBrowse link
G Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein affects the activity of TAL1 protein] CTD PMID:21245298 NCBI chr 5:128,586,776...128,600,976
Ensembl chr 5:128,587,701...128,600,976 		JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of and affects the localization of TARDBP protein]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of TARDBP protein] CTD PMID:25884947 PMID:35405287 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055 		JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases expression ISO Sirolimus results in decreased expression of TARS1 mRNA CTD PMID:11355896 NCBI chr 2:60,368,893...60,387,715
Ensembl chr 2:60,367,796...60,387,717 		JBrowse link
G Tax1bp1 Tax1 binding protein 1 increases expression ISO Sirolimus results in increased expression of TAX1BP1 mRNA CTD PMID:11355896 NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100 		JBrowse link
G Tcf19 transcription factor 19 multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of TCF19 mRNA CTD PMID:19016759 NCBI chr20:3,218,756...3,222,861
Ensembl chr20:3,218,693...3,223,271 		JBrowse link
G Tead1 TEA domain transcription factor 1 multiple interactions ISO Sirolimus promotes the reaction [TP73 protein affects the activity of TEAD1 protein] CTD PMID:21245298 NCBI chr 1:166,791,900...167,010,591
Ensembl chr 1:166,792,628...167,003,369 		JBrowse link
G Tert telomerase reverse transcriptase decreases expression ISO Sirolimus results in decreased expression of TERT mRNA; Sirolimus results in decreased expression of TERT protein CTD PMID:12939469 PMID:16455087 PMID:17996122 PMID:20863555 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tfeb transcription factor EB affects localization
multiple interactions
increases expression		 ISO Sirolimus affects the localization of TFEB protein
Sirolimus inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in decreased expression of TFEB protein]
Sirolimus results in increased expression of TFEB protein		 CTD PMID:28366621 PMID:37951334 PMID:38574842 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
increases response to substance		 ISO
EXP		 [Sirolimus binds to FKBP1A protein] which results in increased activity of TGFB1 protein; [Sirolimus co-treated with TGFB1 protein] affects the localization of CDK2 protein; [Sirolimus co-treated with TGFB1 protein] affects the localization of CDKN1B protein; [Sirolimus co-treated with TGFB1 protein] promotes the reaction [CDKN1A protein binds to CDK2 protein]; [Sirolimus co-treated with TGFB1 protein] results in decreased phosphorylation of RB1 protein; [Sirolimus co-treated with TGFB1 protein] results in increased expression of CDKN1A protein; [TGFB1 protein co-treated with Sirolimus] inhibits the reaction [[E2F4 protein binds to RBL1 protein] which binds to CDK2 protein]; [TGFB1 protein co-treated with Sirolimus] inhibits the reaction [[E2F4 protein binds to RBL2 protein] which binds to CDK2 protein]; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1A protein]; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1B protein]; [TGFB1 protein co-treated with Sirolimus] results in decreased activity of CDK2 protein; [TGFB1 protein co-treated with Sirolimus] results in decreased expression of E2F1 mRNA; [TGFB1 protein co-treated with Sirolimus] results in decreased expression of E2F1 protein; [TGFB1 protein co-treated with Sirolimus] results in decreased phosphorylation of CDK2 protein; [TGFB1 protein co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein; [TGFB1 protein co-treated with Sirolimus] results in increased expression of CDKN1A protein; [TGFB1 protein modified form co-treated with Sirolimus] results in decreased expression of IL6 mRNA; [TGFB1 protein modified form co-treated with Sirolimus] results in decreased expression of IL6 protein; [TGFB1 protein modified form co-treated with Sirolimus] results in increased expression of FOXP3 mRNA; [TGFB1 protein modified form co-treated with Sirolimus] results in increased expression of FOXP3 protein
Sirolimus results in decreased expression of TGFB1 mRNA
Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Sirolimus inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Sirolimus inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]; Sirolimus inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
TGFB1 protein results in increased susceptibility to Sirolimus
[Sirolimus co-treated with TGFB1 protein] affects the localization of CDK2 protein; [Sirolimus co-treated with TGFB1 protein] affects the localization of CDKN1B protein; [Sirolimus co-treated with TGFB1 protein] promotes the reaction [CDKN1B protein binds to CDK2 protein]; [Sirolimus co-treated with TGFB1 protein] results in decreased activity of CDK2 protein; [Sirolimus co-treated with TGFB1 protein] results in decreased phosphorylation of RB1 protein; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1B protein]; [TGFB1 protein co-treated with Sirolimus] results in decreased expression of E2F1 protein; [TGFB1 protein co-treated with Sirolimus] results in decreased expression of MYBL2 protein; [TGFB1 protein co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein; Sirolimus inhibits the reaction [[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Sirolimus inhibits the reaction [TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]]; Sirolimus inhibits the reaction [TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein]]; Sirolimus inhibits the reaction [TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]]; Sirolimus inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CD mRNA]; Sirolimus inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CG mRNA]; Sirolimus inhibits the reaction [TGFB1 protein results in increased expression of PIK3CA mRNA]; Sirolimus inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA]		 CTD PMID:10535884 PMID:12417722 PMID:14979923 PMID:17050028 PMID:17550925 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 increases expression ISO Sirolimus results in increased expression of TGFBR3 mRNA CTD PMID:11355896 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341 		JBrowse link
G Tgm2 transglutaminase 2 decreases expression ISO Sirolimus results in decreased expression of TGM2 mRNA CTD PMID:11355896 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981 		JBrowse link
G Timeless timeless circadian regulator multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of TIMELESS mRNA CTD PMID:19016759 NCBI chr 7:654,804...678,769
Ensembl chr 7:654,822...678,738 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression ISO Sirolimus results in decreased expression of TIMP3 mRNA; Sirolimus results in decreased expression of TIMP3 protein CTD PMID:21742783 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Tmem14c transmembrane protein 14C multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in increased expression of TMEM14C mRNA] CTD PMID:21245298 NCBI chr17:23,733,769...23,739,906
Ensembl chr17:23,733,894...23,753,320 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases secretion
increases expression		 ISO
EXP		 [Sirolimus co-treated with TNF protein] results in decreased expression of SQSTM1 protein; [Sirolimus co-treated with TNF protein] results in increased expression of ATG5 mRNA; [Sirolimus co-treated with TNF protein] results in increased expression of ATG7 mRNA; [Sirolimus co-treated with TNF protein] results in increased expression of BECN1 protein; [TNF protein co-treated with Sirolimus co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein; [TNF protein co-treated with Sirolimus] results in decreased expression of SUV39H1 protein; Sirolimus inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [TNF protein results in decreased expression of PTEN protein]; Sirolimus inhibits the reaction [TNF protein results in decreased expression of TSC2 mRNA]; Sirolimus inhibits the reaction [TNF protein results in decreased expression of TSC2 protein]; Sirolimus inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]; Sirolimus promotes the reaction [TNF protein results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [TNF protein results in increased expression of F3 protein]
Sirolimus inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Sirolimus inhibits the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Sirolimus inhibits the reaction [Silicon Dioxide results in increased expression of TNF protein]; Sirolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADL mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADM mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT1B mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT2 mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARA mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARA protein]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A protein]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 protein]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of TNF protein]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]]
Sirolimus results in decreased expression of TNF mRNA
Sirolimus results in decreased secretion of TNF protein
[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Sirolimus inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Sirolimus inhibits the reaction [Poloxalene results in increased expression of TNF protein]; Sirolimus inhibits the reaction [TNF protein results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein]; Sirolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6 protein]
Sirolimus results in increased expression of TNF		 CTD PMID:12531798 PMID:14502240 PMID:16314788 PMID:19567381 PMID:19810018 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Sirolimus inhibits the reaction [TNFSF11 protein results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RPS6 protein] CTD PMID:14502240 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
decreases phosphorylation		 ISO
EXP		 [Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of TP53 protein; Sirolimus inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]; Sirolimus promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]; Sirolimus promotes the reaction [TP53 protein results in increased expression of BBC3 protein]
Sirolimus inhibits the reaction [arsenite results in increased expression of and results in increased phosphorylation of TRP53 protein]
Sirolimus results in increased expression of TP53 mRNA
Sirolimus results in decreased phosphorylation of TP53 protein		 CTD PMID:11602639 PMID:19560264 PMID:23396362 PMID:24971338 PMID:30555576 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp63 tumor protein p63 decreases expression ISO Sirolimus results in decreased expression of TP63 protein
Sirolimus results in decreased expression of TRP63 protein		 CTD PMID:20038814 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Tp73 tumor protein p73 multiple interactions
increases expression		 ISO [[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of BBC3 protein; [[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of PMAIP1 protein; [Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein; Sirolimus inhibits the reaction [TP73 protein affects the activity of HEN1 protein]; Sirolimus inhibits the reaction [TP73 protein affects the activity of HOXA9 protein]; Sirolimus inhibits the reaction [TP73 protein affects the activity of TAL1 protein]; Sirolimus inhibits the reaction [TP73 protein affects the activity of ZIC2 protein]; Sirolimus inhibits the reaction [TP73 protein results in decreased expression of ACER2 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in decreased expression of JMY mRNA]; Sirolimus inhibits the reaction [TP73 protein results in decreased expression of MIR181A2 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in decreased expression of NR1H4 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in decreased expression of RPL7P26 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in decreased expression of SCD mRNA]; Sirolimus inhibits the reaction [TP73 protein results in decreased expression of SERPINE1 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in decreased expression of YPEL1 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of ABTB3 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of AOPEP mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of CAV3 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of CCNG2 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of CHRNB3 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of DEPTOR mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of FAXDC2 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of FBXO32 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of FGF7 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of FOLR1 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of FTL mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of ING4 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of MBNL2 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of MTURN mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of MYLK mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of MYOF mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of NMU mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of OXA1L mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of POLR1H mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of SEMA3C mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of SIRT2 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of SMIM14 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of STARD10 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of SYT1 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of TMEM14C mRNA]; Sirolimus promotes the reaction [TP73 protein affects the activity of GCM2 protein]; Sirolimus promotes the reaction [TP73 protein affects the activity of PAX8 protein]; Sirolimus promotes the reaction [TP73 protein affects the activity of REST protein]; Sirolimus promotes the reaction [TP73 protein affects the activity of TEAD1 protein]; Sirolimus promotes the reaction [TP73 protein binds to MDM2 promoter]; Sirolimus promotes the reaction [TP73 protein binds to RPS27L promoter]; Sirolimus promotes the reaction [TP73 protein binds to RRAD promoter]; TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR151 mRNA]; TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR190A mRNA]; TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR29C mRNA]; TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR324 mRNA]; TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR379 mRNA]; TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR433 mRNA]; TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR503 mRNA]; TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR508 mRNA]; TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR650 mRNA]; TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR654 mRNA]; TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR758 mRNA]; TP73 protein promotes the reaction [Sirolimus results in increased expression of MIR760 mRNA]; TP73 protein results in increased susceptibility to [Sirolimus co-treated with Cisplatin]
Sirolimus results in increased expression of TP73 protein		 CTD PMID:20686837 PMID:21245298 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Tpp2 tripeptidyl peptidase 2 multiple interactions ISO Sirolimus promotes the reaction [Etoposide affects the localization of TPP2 protein] CTD PMID:20643100 NCBI chr 9:46,046,712...46,128,157
Ensembl chr 9:46,046,632...46,128,157 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO [(+)-JQ1 compound co-treated with Sirolimus] affects the expression of TRIB3 mRNA CTD PMID:25307878 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Trpm6 transient receptor potential cation channel, subfamily M, member 6 multiple interactions
increases expression		 EXP rosiglitazone inhibits the reaction [Sirolimus results in increased expression of TRPM6 protein] CTD PMID:19656910 NCBI chr 1:216,136,407...216,320,523
Ensembl chr 1:216,170,038...216,320,520 		JBrowse link
G Tsc1 TSC complex subunit 1 multiple interactions ISO Sirolimus inhibits the reaction [TSC1 gene mutant form results in decreased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [TSC1 gene mutant form results in decreased phosphorylation of GSK3B protein]; Sirolimus inhibits the reaction [TSC1 gene mutant form results in increased phosphorylation of RPS6KB1 protein] CTD PMID:18495876 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674 		JBrowse link
G Tsc2 TSC complex subunit 2 multiple interactions EXP
ISO		 Sirolimus inhibits the reaction [Resveratrol inhibits the reaction [TSC2 protein results in decreased phosphorylation of RPS6KB1 protein]]; Sirolimus inhibits the reaction [TSC2 gene mutant form results in increased expression of DDIT3 protein]; Sirolimus inhibits the reaction [TSC2 gene mutant form results in increased expression of ERO1A mRNA]; Sirolimus inhibits the reaction [TSC2 gene mutant form results in increased expression of HMOX1 protein]; TSC2 protein inhibits the reaction [[Sirolimus co-treated with Resveratrol] results in increased cleavage of PARP1 protein]
[Resveratrol co-treated with Sirolimus] inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of EIF4B protein]; [Sirolimus co-treated with Resveratrol] inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of RPS6KB1 protein]; [Sirolimus co-treated with Resveratrol] promotes the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Sirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1S1 protein]]; Sirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1S1 protein]; Sirolimus inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of EIF4B protein]; Sirolimus inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of RPS6KB1 protein]; TSC2 gene mutant form promotes the reaction [[Sirolimus co-treated with Resveratrol] results in increased stability of PDCD4 protein]
Sirolimus inhibits the reaction [TNF protein results in decreased expression of TSC2 mRNA]; Sirolimus inhibits the reaction [TNF protein results in decreased expression of TSC2 protein]; TSC2 gene mutant form promotes the reaction [[Resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein]; TSC2 gene mutant form promotes the reaction [Sirolimus results in decreased phosphorylation of RPS6 protein]		 CTD PMID:19420259 PMID:24304514 PMID:31676321 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Ttk Ttk protein kinase multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of TTK mRNA CTD PMID:19016759 NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651 		JBrowse link
G Tyms thymidylate synthetase decreases expression ISO Sirolimus results in decreased expression of TYMS; Sirolimus results in decreased expression of TYMS mRNA CTD PMID:19764996 PMID:20682991 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions
increases expression		 EXP
ISO		 Sirolimus affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]; Sirolimus promotes the reaction [2,4,4'-trichlorobiphenyl results in increased expression of ULK1 protein]; Sirolimus promotes the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of ULK1 protein]
Sirolimus results in increased expression of ULK1 protein
Sirolimus promotes the reaction [2,4,4'-trichlorobiphenyl results in increased expression of ULK1 protein]; Sirolimus promotes the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of ULK1 protein]; Sirolimus promotes the reaction [Alpha-Amanitin results in increased expression of ULK1 protein]		 CTD PMID:29128638 PMID:29518472 PMID:33070465 PMID:37329965 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
G Uri1 URI1, prefoldin-like chaperone decreases response to substance ISO URI1 results in decreased susceptibility to Sirolimus CTD PMID:21397856 NCBI chr 1:90,646,392...90,704,811
Ensembl chr 1:90,646,393...90,709,026 		JBrowse link
G Usp7 ubiquitin specific peptidase 7 multiple interactions ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Sirolimus inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein]]; Sirolimus inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein] CTD PMID:32802178 NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355 		JBrowse link
G Vasn vasorin decreases expression EXP Sirolimus results in decreased expression of VASN mRNA CTD PMID:17028423 NCBI chr10:10,917,750...10,928,259
Ensembl chr10:10,917,605...10,928,357 		JBrowse link
G Vcan versican increases expression EXP Sirolimus results in increased expression of VCAN mRNA CTD PMID:21865292 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637 		JBrowse link
G Vcp valosin-containing protein multiple interactions ISO Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of SQSTM1 protein]
Sirolimus inhibits the reaction [VCP protein mutant form results in decreased expression of MAP1LC3B protein]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of OPTN protein]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of RPS6KB1 protein modified form]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of TARDBP protein]		 CTD PMID:25884947 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO
EXP		 [Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Sirolimus inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; Sirolimus inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]; Sirolimus inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]
Sirolimus inhibits the reaction [cyanoginosin LR results in increased expression of VEGFA protein]
[Sirolimus co-treated with Hydrogen Peroxide] results in increased expression of VEGFA mRNA
Sirolimus results in decreased expression of VEGFA protein
Sirolimus results in decreased expression of VEGFA mRNA		 CTD PMID:15050414 PMID:15930297 PMID:16682453 PMID:17968710 PMID:20554536 More... NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin multiple interactions ISO
EXP		 Sirolimus inhibits the reaction [sodium arsenite results in increased expression of VIM protein]
NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in increased expression of VIM protein]]; Sirolimus inhibits the reaction [Paraquat results in increased expression of VIM mRNA]; Sirolimus inhibits the reaction [Paraquat results in increased expression of VIM protein]		 CTD PMID:28624451 PMID:28888487 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Wt1 WT1 transcription factor decreases expression ISO Sirolimus results in decreased expression of WT1 mRNA; Sirolimus results in decreased expression of WT1 protein; Sirolimus results in decreased expression of WT1 protein mutant form CTD PMID:15782132 PMID:18927120 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Sirolimus inhibits the reaction [arsenite results in increased splicing of XBP1 mRNA] CTD PMID:22215663 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO Sirolimus promotes the reaction [Cisplatin results in decreased expression of XIAP protein] CTD PMID:18058806 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Ypel1 yippee-like 1 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein results in decreased expression of YPEL1 mRNA] CTD PMID:21245298 NCBI chr11:83,921,799...83,936,409 JBrowse link
G Yy1 YY1 transcription factor multiple interactions ISO Sirolimus inhibits the reaction [Glucose results in increased phosphorylation of YY1 protein] CTD PMID:35445903 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
G Zfp628 zinc finger protein 628 decreases expression ISO Sirolimus results in decreased expression of ZNF628 mRNA CTD PMID:24356939 NCBI chr 1:68,913,600...68,921,186
Ensembl chr 1:68,910,401...68,921,243 		JBrowse link
G Zic2 Zic family member 2 multiple interactions ISO Sirolimus inhibits the reaction [TP73 protein affects the activity of ZIC2 protein] CTD PMID:21245298 NCBI chr15:99,576,697...99,581,522
Ensembl chr15:99,576,697...99,581,522 		JBrowse link
G Zwint ZW10 interacting kinetochore protein multiple interactions ISO [fulvestrant co-treated with Sirolimus] results in decreased expression of ZWINT mRNA CTD PMID:19016759 NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957 		JBrowse link
torin 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein] CTD PMID:30482226 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of CEBPB protein alternative form] CTD PMID:30482226 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]
1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]		 CTD PMID:30482226 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases phosphorylation ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in increased phosphorylation of EEF2 protein CTD PMID:25940091 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 mRNA]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 mRNA]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 protein] CTD PMID:26455392 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases phosphorylation		 ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one promotes the reaction [EIF4EBP1 protein binds to 7-methylguanosine triphosphate]
1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased phosphorylation of EIF4EBP1 protein		 CTD PMID:25940091 PMID:29650965 PMID:29945972 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma 1 multiple interactions ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EIF4G1 protein binds to 7-methylguanosine triphosphate]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EIF4G1 protein binds to PABPC1 mRNA]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EIF4G1 protein binds to RPL32 mRNA]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EIF4G1 protein binds to RPS20 mRNA]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EIF4G1 protein binds to RPS6 mRNA] CTD PMID:25940091 NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Foxg1 forkhead box G1 multiple interactions ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 mRNA]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EGFR protein mutant form results in increased expression of FOXG1 protein] CTD PMID:26455392 NCBI chr 6:66,674,797...66,677,611
Ensembl chr 6:66,666,587...66,678,607 		JBrowse link
G Larp1 La ribonucleoprotein 1, translational regulator multiple interactions
increases response to substance		 ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[MTOR protein binds to RAPTOR protein] which binds to LARP1 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one promotes the reaction [LARP1 protein binds to PABPC1 mRNA]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one promotes the reaction [LARP1 protein binds to RPL32 mRNA]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one promotes the reaction [LARP1 protein binds to RPS20 mRNA]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one promotes the reaction [LARP1 protein binds to RPS6 mRNA]; LARP1 protein promotes the reaction [1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased expression of RPL32 protein]; LARP1 protein promotes the reaction [1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased expression of RPS20 protein]; LARP1 protein promotes the reaction [1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased expression of RPS6 protein]
LARP1 protein results in increased susceptibility to 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one		 CTD PMID:25940091 NCBI chr10:42,191,378...42,246,361
Ensembl chr10:42,191,325...42,243,371 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[MTOR protein binds to RAPTOR protein] which binds to LARP1 protein]
1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased phosphorylation of MTOR protein		 CTD PMID:25940091 PMID:29650965 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Pabpc1 poly(A) binding protein, cytoplasmic 1 decreases expression
multiple interactions		 ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased expression of PABPC1 protein
1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EIF4G1 protein binds to PABPC1 mRNA]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one promotes the reaction [LARP1 protein binds to PABPC1 mRNA]		 CTD PMID:25940091 NCBI chr 7:67,777,438...67,789,731
Ensembl chr 7:67,777,381...67,789,744 		JBrowse link
G Rpl32 ribosomal protein L32 multiple interactions
decreases expression		 ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EIF4G1 protein binds to RPL32 mRNA]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one promotes the reaction [LARP1 protein binds to RPL32 mRNA]; LARP1 protein promotes the reaction [1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased expression of RPL32 protein] CTD PMID:25940091 NCBI chr 4:148,864,048...148,867,612
Ensembl chr 4:148,864,044...148,867,612 		JBrowse link
G Rps20 ribosomal protein S20 multiple interactions
decreases expression		 ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EIF4G1 protein binds to RPS20 mRNA]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one promotes the reaction [LARP1 protein binds to RPS20 mRNA]; LARP1 protein promotes the reaction [1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased expression of RPS20 protein] CTD PMID:25940091 NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
decreases expression		 ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EIF4G1 protein binds to RPS6 mRNA]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one promotes the reaction [LARP1 protein binds to RPS6 mRNA]; LARP1 protein promotes the reaction [1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased expression of RPS6 protein] CTD PMID:25940091 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased phosphorylation of RPS6KB1 protein CTD PMID:21858812 PMID:25940091 PMID:29650965 PMID:29945972 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 multiple interactions ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[MTOR protein binds to RAPTOR protein] which binds to LARP1 protein] CTD PMID:25940091 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983 		JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 mRNA]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EGFR protein mutant form results in increased expression of SOX9 protein] CTD PMID:26455392 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 decreases phosphorylation ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased phosphorylation of TFE3 protein CTD PMID:29945972 NCBI chr  X:14,729,547...14,742,830
Ensembl chr  X:14,729,550...14,742,571 		JBrowse link
G Tfeb transcription factor EB decreases phosphorylation ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased phosphorylation of TFEB protein CTD PMID:29945972 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of TRIB3 protein] CTD PMID:30482226 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 decreases expression ISO 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased expression of ULK1 protein CTD PMID:27629431 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
XL765 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 increases response to substance ISO ALDH5A1 gene mutant form results in increased susceptibility to XL765 CTD PMID:29031482 NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases activity ISO XL765 results in decreased activity of MTOR protein CTD PMID:29031482 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        biochemical role 19571
          enzyme inhibitor 18770
            EC 2.* (transferase) inhibitor 14977
              EC 2.7.* (P-containing group transferase) inhibitor 14390
                protein kinase inhibitor 13998
                  mTOR inhibitor 540
                    AZD-8055 0
                    BGT226 0
                    BGT226 free base 0
                    Ku-0063794 3
                    PI-103 0
                    XL765 2
                    dactolisib 30
                    everolimus 46
                    oleuropein aglycone 0
                    omipalisib 16
                    ridaforolimus 7
                    sapanisertib 16
                    sirolimus + 529
                    torin 1 22
                    torin 2 0
                    torkinib 0
paths to the root