Gene: Rest (RE1-silencing transcription factor) Rattus norvegicus
Analyze
Symbol:
Rest
Name:
RE1-silencing transcription factor
Description:
Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding activity; and transcription factor binding activity. Involved in several processes, including generation of neurons; negative regulation of cellular biosynthetic process; and negative regulation of dense core granule biogenesis. Localizes to chromatin; nucleus; and transcriptional repressor complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 9-cis-retinoic acid.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
neural-restrictive silencer factor; Nrsf; zinc finger transcription factor REST protein
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
REST (RE1 silencing transcription factor) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Rest (RE1-silencing transcription factor) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Pan paniscus (bonobo/pygmy chimpanzee):
REST (RE1 silencing transcription factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
REST (RE1 silencing transcription factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Rest (RE1 silencing transcription factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
REST (RE1 silencing transcription factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
REST (RE1 silencing transcription factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Rest (RE1 silencing transcription factor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Rest (RE1-silencing transcription factor)
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|OrthoFinder|OrthoInspector|Hieranoid)
Homo sapiens (human):
REST (RE1 silencing transcription factor)
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|HGNC|OMA|OrthoInspector|OrthoFinder|Hieranoid)
Danio rerio (zebrafish):
rest (RE1-silencing transcription factor)
Alliance
DIOPT (InParanoid|PhylomeDB|PANTHER|OrthoFinder|OrthoInspector|Hieranoid)
Caenorhabditis elegans (roundworm):
hbl-1
Alliance
DIOPT (Ensembl Compara|PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 14 33,131,985 - 33,152,019 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 14 33,134,511 - 33,164,141 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 14 32,925,741 - 32,951,551 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 14 33,136,046 - 33,151,142 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 14 33,136,045 - 33,151,142 (-) NCBI Celera 14 30,181,687 - 30,196,879 (-) NCBI Celera Cytogenetic Map 14 p11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
nephroblastoma ISO RGD:1347756 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26551668 visual epilepsy ISO RGD:1347756 11554173 CTD Direct Evidence: therapeutic CTD PMID:21905079 Wilms Tumor 6 ISO RGD:1347756 11554173 CTD Direct Evidence: marker/mechanism CTD
Imported Annotations - OMIM
autosomal dominant nonsyndromic deafness 27 ISO RGD:1347756 7240710 OMIM gingival fibromatosis 5 ISO RGD:1347756 7240710 OMIM Wilms Tumor 6 susceptibility ISO RGD:1347756 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of REST mRNA] CTD PMID:31150632 1,2-dimethylhydrazine increases expression EXP 6480464 1, 2-Dimethylhydrazine results in increased expression of REST mRNA CTD PMID:27840820 17beta-estradiol affects expression ISO RGD:1347756 6480464 Estradiol affects the expression of REST mRNA CTD PMID:22574217 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732239 6480464 Tetrachlorodibenzodioxin results in increased expression of REST mRNA CTD PMID:19770486 2-hydroxypropanoic acid increases expression ISO RGD:1347756 6480464 Lactic Acid results in increased expression of REST mRNA CTD PMID:30851411 5-fluorouracil affects expression ISO RGD:1347756 6480464 Fluorouracil affects the expression of REST mRNA CTD PMID:16584549 5-fluorouracil decreases expression ISO RGD:732239 6480464 Fluorouracil results in decreased expression of REST protein CTD PMID:21296659 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions ISO RGD:1347756 6480464 6-chloro-2 more ... CTD PMID:26307266 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide increases expression ISO RGD:1347756 6480464 6-chloro-2 more ... CTD PMID:26307266 9-cis-retinoic acid increases expression EXP 6480464 Alitretinoin results in increased expression of REST mRNA CTD PMID:16648578 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of REST mRNA CTD PMID:28959563 aflatoxin B1 increases expression ISO RGD:732239 6480464 Aflatoxin B1 results in increased expression of REST mRNA CTD PMID:19770486 all-trans-retinoic acid multiple interactions ISO RGD:1347756 6480464 ZMYND8 protein affects the reaction [Tretinoin results in decreased expression of REST mRNA] CTD PMID:26655721 all-trans-retinoic acid decreases expression ISO RGD:1347756 6480464 Tretinoin results in decreased expression of REST mRNA CTD PMID:26655721 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of REST mRNA CTD PMID:16483693 Aroclor 1254 decreases expression ISO RGD:1347756 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of REST mRNA CTD PMID:16934159 arsenous acid increases expression ISO RGD:1347756 6480464 Arsenic Trioxide results in increased expression of REST mRNA CTD PMID:20458559 benzo[a]pyrene decreases expression ISO RGD:732239 6480464 Benzo(a)pyrene results in decreased expression of REST mRNA CTD PMID:22228805 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1347756 6480464 7 more ... CTD PMID:26238291 bexarotene increases expression EXP 6480464 bexarotene results in increased expression of REST mRNA CTD PMID:16648578 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of REST mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:1347756 6480464 bisphenol A results in decreased expression of REST mRNA CTD PMID:30953815 bromochloroacetic acid decreases expression ISO RGD:732239 6480464 bromochloroacetic acid results in decreased expression of REST protein CTD PMID:21296659 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of REST mRNA CTD PMID:19167457 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of REST promoter CTD PMID:22457795 carbamazepine multiple interactions ISO RGD:1347756 6480464 Carbamazepine inhibits the reaction [REST protein results in increased expression of TAC3 mRNA] CTD PMID:19539370 copper(II) sulfate increases expression ISO RGD:1347756 6480464 Copper Sulfate results in increased expression of REST mRNA CTD PMID:19549813 decabromodiphenyl ether multiple interactions ISO RGD:732239 6480464 BESEB CDRI-08 inhibits the reaction [decabromobiphenyl ether inhibits the reaction [REST protein binds to GRIN1 promoter]], decabromobiphenyl ether inhibits the reaction [REST protein binds to GRIN1 promoter] CTD PMID:26413122 diarsenic trioxide increases expression ISO RGD:1347756 6480464 Arsenic Trioxide results in increased expression of REST mRNA CTD PMID:20458559 diuron increases expression EXP 6480464 Diuron results in increased expression of REST mRNA CTD PMID:21551480 dorsomorphin multiple interactions ISO RGD:1347756 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of REST mRNA CTD PMID:27188386 doxorubicin affects expression ISO RGD:732239 6480464 Doxorubicin affects the expression of REST mRNA CTD PMID:15033991 doxorubicin decreases expression ISO RGD:732239 6480464 Doxorubicin results in decreased expression of REST mRNA CTD PMID:19277126 fenamidone increases expression ISO RGD:732239 6480464 fenamidone results in increased expression of REST mRNA CTD PMID:27029645 kainic acid multiple interactions EXP 6480464 Kainic Acid promotes the reaction [REST protein binds to HCN1 intron] more ... CTD PMID:21905079 kainic acid increases expression EXP 6480464 Kainic Acid results in increased expression of REST protein CTD PMID:21905079 lead diacetate multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of REST protein more ... CTD PMID:30742882 lead diacetate increases expression ISO RGD:732239 6480464 lead acetate results in increased expression of REST mRNA, lead acetate results in increased expression of REST protein CTD PMID:29505838 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of REST mRNA, lead acetate results in increased expression of REST protein CTD PMID:29505838 lead diacetate multiple interactions ISO RGD:732239 6480464 REST protein promotes the reaction [lead acetate results in decreased expression of SV2C mRNA], REST protein promotes the reaction [lead acetate results in decreased expression of SV2C protein] CTD PMID:29505838 lead(0) multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of REST protein more ... CTD PMID:30742882 lead(2+) multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of REST protein more ... CTD PMID:30742882 leflunomide increases expression ISO RGD:1347756 6480464 leflunomide results in increased expression of REST mRNA CTD PMID:28988120 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of REST mRNA, methylmercuric chloride results in increased expression of REST protein CTD PMID:29522201 methylmercury chloride multiple interactions EXP 6480464 JUND affects the reaction [methylmercuric chloride results in increased expression of REST mRNA] more ... CTD PMID:29522201 monosodium L-glutamate multiple interactions ISO RGD:732239 6480464 SB 203580 inhibits the reaction [Sodium Glutamate results in increased expression of REST mRNA] CTD PMID:16782274 monosodium L-glutamate increases expression ISO RGD:732239 6480464 Sodium Glutamate results in increased expression of REST mRNA CTD PMID:16782274 N-methyl-4-phenylpyridinium affects localization ISO RGD:1347756 6480464 1-Methyl-4-phenylpyridinium affects the localization of REST protein CTD PMID:19631241 N-methyl-4-phenylpyridinium increases expression ISO RGD:1347756 6480464 1-Methyl-4-phenylpyridinium results in increased expression of REST mRNA CTD PMID:19631241 N-methyl-4-phenylpyridinium affects response to substance ISO RGD:1347756 6480464 REST protein affects the susceptibility to 1-Methyl-4-phenylpyridinium CTD PMID:19631241 panobinostat multiple interactions ISO RGD:1347756 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of REST mRNA CTD PMID:27188386 panobinostat increases expression ISO RGD:1347756 6480464 panobinostat results in increased expression of REST mRNA CTD PMID:26272509 paracetamol affects expression ISO RGD:732239 6480464 Acetaminophen affects the expression of REST mRNA CTD PMID:17562736 phenobarbital decreases expression ISO RGD:732239 6480464 Phenobarbital results in decreased expression of REST mRNA CTD PMID:23091169 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of REST mRNA CTD PMID:19162173 rac-lactic acid increases expression ISO RGD:1347756 6480464 Lactic Acid results in increased expression of REST mRNA CTD PMID:30851411 resveratrol multiple interactions ISO RGD:1347756 6480464 6-chloro-2 more ... CTD PMID:26307266 resveratrol multiple interactions EXP 6480464 JUN protein promotes the reaction [resveratrol inhibits the reaction [2 more ... CTD PMID:26307266 resveratrol decreases expression ISO RGD:1347756 6480464 resveratrol results in decreased expression of REST mRNA, resveratrol results in decreased expression of REST protein CTD PMID:26307266 SB 203580 multiple interactions ISO RGD:732239 6480464 SB 203580 inhibits the reaction [Sodium Glutamate results in increased expression of REST mRNA] CTD PMID:16782274 SB 431542 multiple interactions ISO RGD:1347756 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of REST mRNA CTD PMID:27188386 sirolimus multiple interactions ISO RGD:1347756 6480464 Sirolimus promotes the reaction [TP73 protein affects the activity of REST protein] CTD PMID:21245298 sodium arsenate increases expression ISO RGD:732239 6480464 sodium arsenate results in increased expression of REST mRNA CTD PMID:27751817 succimer multiple interactions ISO RGD:732239 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of REST mRNA CTD PMID:26378955 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of REST mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of REST mRNA] CTD PMID:31150632 trichostatin A decreases activity ISO RGD:1347756 6480464 trichostatin A results in decreased activity of REST protein CTD PMID:16330548 troglitazone decreases expression ISO RGD:732239 6480464 troglitazone results in decreased expression of REST mRNA CTD PMID:28973697 urethane increases expression ISO RGD:1347756 6480464 Urethane results in increased expression of REST mRNA CTD PMID:28818685 valproic acid increases methylation ISO RGD:1347756 6480464 Valproic Acid results in increased methylation of REST gene CTD PMID:29154799 valproic acid decreases expression ISO RGD:1347756 6480464 Valproic Acid results in decreased expression of REST mRNA CTD PMID:23179753 , PMID:27188386 vorinostat decreases expression ISO RGD:1347756 6480464 vorinostat results in decreased expression of REST mRNA CTD PMID:27188386
Biological Process auditory receptor cell stereocilium organization ISS UniProtKB:Q8VIG1-2 1600115 GO_REF:0000024 UniProt GO_REF:0000024 auditory receptor cell stereocilium organization ISO RGD:732239 1624291 (MGI:MGI:6193260, PMID:29961578) RGD MGI:MGI:6193260 , PMID:29961578 cardiac muscle cell myoblast differentiation ISO RGD:732239 1624291 (MGI:MGI:5009770, PMID:21199191) RGD MGI:MGI:5009770 , PMID:21199191 cardiac muscle cell myoblast differentiation ISS UniProtKB:Q8VIG1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to drug ISO RGD:1347756 1624291 (PMID:20564196) RGD PMID:20564196 cellular response to drug ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to drug IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to electrical stimulus ISO RGD:1347756 1624291 (PMID:18570921) RGD PMID:18570921 cellular response to electrical stimulus ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to electrical stimulus IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to glucocorticoid stimulus ISO RGD:1347756 1624291 (PMID:17984088) RGD PMID:17984088 cellular response to glucocorticoid stimulus ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to glucocorticoid stimulus IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 detection of mechanical stimulus involved in sensory perception of sound ISS UniProtKB:Q8VIG1-2 1600115 GO_REF:0000024 UniProt GO_REF:0000024 detection of mechanical stimulus involved in sensory perception of sound ISO RGD:732239 1624291 (MGI:MGI:6193260, PMID:29961578) RGD MGI:MGI:6193260 , PMID:29961578 hematopoietic progenitor cell differentiation ISO RGD:732239 1624291 (MGI:MGI:5520108, PMID:24029230) RGD MGI:MGI:5520108 , PMID:24029230 histone H4 deacetylation ISO RGD:1347756 1624291 (PMID:17555596) RGD PMID:17555596 histone H4 deacetylation ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 histone H4 deacetylation IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 modification of synaptic structure IMP 14397585 PMID:22960932 UniProt negative regulation by host of viral transcription ISO RGD:1347756 1624291 (PMID:17555596) RGD PMID:17555596 negative regulation by host of viral transcription ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation by host of viral transcription IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of aldosterone biosynthetic process IMP 4891166 PMID:19342457 UniProt negative regulation of aldosterone biosynthetic process IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of aldosterone biosynthetic process ISO RGD:1347756 1624291 (PMID:19342457) RGD PMID:19342457 negative regulation of amniotic stem cell differentiation ISO RGD:1347756 1624291 (PMID:20942606) RGD PMID:20942606 negative regulation of amniotic stem cell differentiation ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of amniotic stem cell differentiation IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of calcium ion-dependent exocytosis IMP 8554180 PMID:21536750 UniProt negative regulation of cell population proliferation ISO RGD:1347756 1624291 (PMID:20564196) RGD PMID:20564196 negative regulation of cell population proliferation ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of cell population proliferation IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cortisol biosynthetic process IMP 4891166 PMID:19342457 UniProt negative regulation of cortisol biosynthetic process IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cortisol biosynthetic process ISO RGD:1347756 1624291 (PMID:19342457) RGD PMID:19342457 negative regulation of dense core granule biogenesis IMP 8554180 PMID:21536750 UniProt negative regulation of gene expression ISO RGD:1347756 1624291 (PMID:20564196) RGD PMID:20564196 negative regulation of gene expression ISO RGD:732239 1624291 (MGI:MGI:1289984 more ... RGD MGI:MGI:1289984 more ... negative regulation of gene expression ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of gene expression IMP 14397584 PMID:25108103 UniProt negative regulation of insulin secretion ISO RGD:1347756 1624291 (PMID:20942606) RGD PMID:20942606 negative regulation of insulin secretion ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of insulin secretion IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of mesenchymal stem cell differentiation ISO RGD:1347756 1624291 (PMID:18570921) RGD PMID:18570921 negative regulation of neurogenesis ISO RGD:732239 1624291 MGI:MGI:2654470 (MGI:MGI:3706460 , PMID:17403776) RGD MGI:MGI:3706460 , PMID:17403776 negative regulation of neurogenesis ISS UniProtKB:Q8VIG1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of neuron differentiation IMP 1299303 RGD negative regulation of neuron differentiation ISO RGD:732239 1624291 (MGI:MGI:3580760 more ... RGD MGI:MGI:3580760 more ... negative regulation of neuron differentiation ISO RGD:1347756 1624291 (PMID:18570921), (PMID:21258371) RGD PMID:18570921 , PMID:21258371 negative regulation of neuron differentiation IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of neuron differentiation ISS UniProtKB:Q8VIG1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of neuron differentiation ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of neuron differentiation IEA InterPro:IPR027757 1600115 GO_REF:0000002 InterPro GO_REF:0000002 negative regulation of oxidative stress-induced neuron death ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of oxidative stress-induced neuron death ISO RGD:1347756 1624291 (PMID:24670762) RGD PMID:24670762 negative regulation of oxidative stress-induced neuron death IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II NAS 633753 RGD negative regulation of transcription by RNA polymerase II IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II ISO RGD:1347756 1624291 (PMID:21284946), (PMID:8568247) RGD PMID:21284946 , PMID:8568247 negative regulation of transcription by RNA polymerase II IMP 14397585 PMID:22960932 UniProt negative regulation of transcription regulatory region DNA binding ISS UniProtKB:Q8VIG1-2 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of transcription regulatory region DNA binding ISO RGD:732239 1624291 (MGI:MGI:6294407, PMID:10490617) RGD MGI:MGI:6294407 , PMID:10490617 negative regulation of transcription, DNA-templated IMP 2306452 RGD negative regulation of transcription, DNA-templated ISO RGD:1347756 1624291 (PMID:10449787), (PMID:10734093), (PMID:11741002), (PMID:11779185), (PMID:17984088), (PMID:18570921), (PMID:19342457), (PMID:20942606), (PMID:27531581), (PMID:7697725) RGD PMID:10449787 more ... negative regulation of transcription, DNA-templated IDA 8553999 PMID:17130167 UniProt negative regulation of transcription, DNA-templated ISO RGD:732239 1624291 (MGI:MGI:3047179 more ... RGD MGI:MGI:3047179 more ... negative regulation of transcription, DNA-templated IDA 4891166 PMID:19342457 UniProt neuromuscular process controlling balance ISS UniProtKB:Q8VIG1-2 1600115 GO_REF:0000024 UniProt GO_REF:0000024 neuromuscular process controlling balance ISO RGD:732239 1624291 (MGI:MGI:6193260, PMID:29961578) RGD MGI:MGI:6193260 , PMID:29961578 neuron differentiation IEP 11570515 RGD neuronal stem cell population maintenance ISS UniProtKB:Q8VIG1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 neuronal stem cell population maintenance ISO RGD:732239 1624291 (MGI:MGI:5906102, PMID:27819263) RGD MGI:MGI:5906102 , PMID:27819263 positive regulation of apoptotic process IEA InterPro:IPR027757 1600115 GO_REF:0000002 InterPro GO_REF:0000002 positive regulation of apoptotic process ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of apoptotic process ISO RGD:1347756 1624291 (PMID:20564196) RGD PMID:20564196 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO RGD:1347756 1624291 (PMID:20564196) RGD PMID:20564196 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of gene expression ISS UniProtKB:Q8VIG1-2 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of gene expression ISO RGD:732239 1624291 (MGI:MGI:6193260 more ... RGD MGI:MGI:6193260 more ... positive regulation of neuron differentiation ISO RGD:732239 1624291 (MGI:MGI:6201823, PMID:21884984) RGD MGI:MGI:6201823 , PMID:21884984 positive regulation of neuron differentiation ISS UniProtKB:Q8VIG1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of oxidative stress-induced neuron death IMP 14397566 PMID:22371606 UniProt positive regulation of stem cell population maintenance ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of stem cell population maintenance ISO RGD:1347756 1624291 (PMID:21258371) RGD PMID:21258371 positive regulation of stem cell population maintenance IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription, DNA-templated ISO RGD:1347756 1624291 (PMID:17984088) RGD PMID:17984088 positive regulation of transcription, DNA-templated IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of alternative mRNA splicing, via spliceosome ISO RGD:732239 1624291 (MGI:MGI:6201823, PMID:21884984) RGD MGI:MGI:6201823 , PMID:21884984 regulation of alternative mRNA splicing, via spliceosome ISS UniProtKB:Q8VIG1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of gene expression ISO RGD:732239 1624291 (MGI:MGI:6114361, PMID:29024663) RGD MGI:MGI:6114361 , PMID:29024663 regulation of osteoblast differentiation ISS UniProtKB:Q8VIG1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of osteoblast differentiation ISO RGD:732239 1624291 (MGI:MGI:5641106, PMID:25838543) RGD MGI:MGI:5641106 , PMID:25838543 regulation of oxidative stress-induced neuron death IMP 1299303 PMID:12657670 UniProt regulation of transcription by RNA polymerase II IEA InterPro:IPR027757 1600115 GO_REF:0000002 InterPro GO_REF:0000002 regulation of transcription, DNA-templated ISS UniProtKB:Q13127-3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of transcription, DNA-templated ISO RGD:1347756 1624291 (PMID:11779185) RGD PMID:11779185 regulation of transcription, DNA-templated IBA PANTHER:PTN001227110 , RGD:621069 13792537 PMID:21873635 GO_Central response to hypoxia ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 response to hypoxia IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to hypoxia ISO RGD:1347756 1624291 (PMID:27531581) RGD PMID:27531581 response to ischemia IEP 1299303 PMID:12657670 UniProt response to ischemia IDA 14397584 PMID:25108103 UniProt response to ischemia IDA 14397566 PMID:22371606 UniProt somatic stem cell population maintenance ISS UniProtKB:Q8VIG1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 somatic stem cell population maintenance ISO RGD:732239 1624291 (MGI:MGI:5906102, PMID:27819263) RGD MGI:MGI:5906102 , PMID:27819263 Cellular Component chromatin IDA 2306452 RGD cytoplasm ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cytoplasm ISO RGD:1347756 1624291 (PMID:24670762), (PMID:27531581), (PMID:30684677) RGD PMID:24670762 more ... cytosol ISO RGD:732239 1624291 (MGI:MGI:5009770, PMID:21199191) RGD MGI:MGI:5009770 , PMID:21199191 cytosol IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:1347756 1624291 RGD GO_REF:0000052 nucleoplasm ISO RGD:1347756 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus IDA 4891166 PMID:19342457 UniProt nucleus ISO RGD:1347756 1624291 (PMID:10734093), (PMID:11741002), (PMID:16417580), (PMID:16442230), (PMID:17984088), (PMID:19342457), (PMID:21258371), (PMID:21284946), (PMID:24670762), (PMID:27531581), (PMID:30684677), (PMID:7697725) RGD PMID:10734093 more ... nucleus IBA PANTHER:PTN001227110 more ... 13792537 PMID:21873635 GO_Central nucleus ISO RGD:732239 1624291 (MGI:MGI:3580760 more ... RGD MGI:MGI:3580760 more ... nucleus IEA InterPro:IPR027757 1600115 GO_REF:0000002 InterPro GO_REF:0000002 nucleus IDA 14397572 PMID:10490617 UniProt nucleus ISS UniProtKB:Q8VIG1-2 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nucleus ISS UniProtKB:Q13127-3 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nucleus IDA 1299303 PMID:12657670 UniProt nucleus IDA 8554025 PMID:7697725 UniProt nucleus IDA 8554180 PMID:21536750 UniProt protein-containing complex IDA 2306469 RGD transcription repressor complex ISO RGD:1347756 1624291 (PMID:10734093) RGD PMID:10734093 transcription repressor complex ISO RGD:732239 1624291 (MGI:MGI:5009400, PMID:17130167) RGD MGI:MGI:5009400 , PMID:17130167 transcription repressor complex IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription repressor complex IDA 8553999 PMID:17130167 UniProt Molecular Function chromatin binding ISS UniProtKB:Q8VIG1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 chromatin binding ISO RGD:732239 1624291 (MGI:MGI:3625674 more ... RGD MGI:MGI:3625674 more ... DNA binding IDA 633753 RGD DNA binding ISO RGD:732239 1624291 (MGI:MGI:3047179, PMID:15240883) RGD MGI:MGI:3047179 , PMID:15240883 DNA-binding transcription factor activity TAS 633753 RGD DNA-binding transcription factor activity ISO RGD:1347756 1624291 (PMID:19342457) RGD PMID:19342457 DNA-binding transcription factor activity IDA 4891166 PMID:19342457 UniProt DNA-binding transcription factor activity, RNA polymerase II-specific IEA InterPro:IPR027757 1600115 GO_REF:0000002 InterPro GO_REF:0000002 DNA-binding transcription repressor activity, RNA polymerase II-specific ISO RGD:732239 1624291 (MGI:MGI:5009400, PMID:17130167) RGD MGI:MGI:5009400 , PMID:17130167 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 8553999 PMID:17130167 UniProt DNA-binding transcription repressor activity, RNA polymerase II-specific ISO RGD:1347756 1624291 (PMID:10449787), (PMID:10734093), (PMID:21284946) RGD PMID:10449787 more ... identical protein binding ISS UniProtKB:Q8VIG1-2 1600115 GO_REF:0000024 UniProt GO_REF:0000024 identical protein binding ISO RGD:732239 1624291 UniProtKB:Q8VIG1-2 (MGI:MGI:6294387 , PMID:11039732) RGD MGI:MGI:6294387 , PMID:11039732 metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000043 UniProt GO_REF:0000043 nucleic acid binding IEA InterPro:IPR013087 1600115 GO_REF:0000002 InterPro GO_REF:0000002 protein binding IPI UniProtKB:Q61967 8554463 PMID:21284946 UniProt protein binding ISO RGD:1347756 1624291 UniProtKB:P41229 more ... RGD PMID:10449787 more ... protein binding ISO RGD:732239 1624291 PR:Q09XV5 more ... RGD MGI:MGI:1354825 more ... protein-containing complex binding IDA 2306469 RGD RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:1347756 1624291 (PMID:17984088), (PMID:8568247) RGD PMID:17984088 , PMID:8568247 RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 RNA polymerase II core promoter sequence-specific DNA binding ISO RGD:732239 1624291 (MGI:MGI:6114361, PMID:29024663) RGD MGI:MGI:6114361 , PMID:29024663 sequence-specific DNA binding ISS UniProtKB:Q8VIG1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 sequence-specific DNA binding ISO RGD:732239 1624291 (MGI:MGI:6294387 more ... RGD MGI:MGI:6294387 more ... sequence-specific DNA binding IDA 14397572 PMID:10490617 UniProt transcription factor binding ISO RGD:1347756 1624291 UniProtKB:Q02447 (PMID:17130167) RGD PMID:17130167 transcription factor binding IPI UniProtKB:A0A0G2K5M1 8553999 PMID:17130167 UniProt transcription factor binding IEA UniProtKB:Q13127 , ensembl:ENSP000003118161600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription regulatory region sequence-specific DNA binding ISS UniProtKB:Q8VIG1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 transcription regulatory region sequence-specific DNA binding ISO RGD:1347756 1624291 (PMID:17555596) RGD PMID:17555596 transcription regulatory region sequence-specific DNA binding ISO RGD:732239 1624291 (MGI:MGI:3580760, PMID:15907476) RGD MGI:MGI:3580760 , PMID:15907476 transcription regulatory region sequence-specific DNA binding ISS UniProtKB:Q13127 1600115 GO_REF:0000024 UniProt GO_REF:0000024
Gene-Chemical Interaction Annotations
