Rest (RE1-silencing transcription factor) - Rat Genome Database

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Gene: Rest (RE1-silencing transcription factor) Rattus norvegicus
Symbol: Rest
Name: RE1-silencing transcription factor
RGD ID: 621069
Description: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of cellular biosynthetic process; negative regulation of dense core granule biogenesis; and response to ischemia. Located in nucleus. Part of chromatin and transcription repressor complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neural-restrictive silencer factor; Nrsf; zinc finger transcription factor REST protein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21430,859,109 - 30,879,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1430,862,553 - 30,894,354 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1431,239,986 - 31,260,061 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,548,313 - 32,568,388 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01431,032,969 - 31,053,042 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,131,985 - 33,152,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,134,511 - 33,164,141 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01432,925,741 - 32,951,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41433,136,046 - 33,151,142 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11433,136,045 - 33,151,142 (-)NCBI
Celera1430,181,687 - 30,196,879 (-)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
auditory receptor cell stereocilium organization  (ISO,ISS)
cardiac muscle cell myoblast differentiation  (ISO,ISS)
cellular response to electrical stimulus  (IEA,ISO,ISS)
cellular response to glucocorticoid stimulus  (IEA,ISO,ISS)
cellular response to xenobiotic stimulus  (IEA,ISO,ISS)
chromatin remodeling  (IMP)
detection of mechanical stimulus involved in sensory perception of sound  (ISO,ISS)
hematopoietic progenitor cell differentiation  (ISO)
modification of synaptic structure  (IMP)
negative regulation by host of viral transcription  (IEA,ISS)
negative regulation of aldosterone biosynthetic process  (IEA,IMP,ISO)
negative regulation of amniotic stem cell differentiation  (IEA,ISO,ISS)
negative regulation of calcium ion-dependent exocytosis  (IMP)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of cortisol biosynthetic process  (IEA,IMP,ISO)
negative regulation of dense core granule biogenesis  (IMP)
negative regulation of DNA-templated transcription  (IBA,IDA,IMP,ISO)
negative regulation of gene expression  (IEA,IMP,ISO,ISS)
negative regulation of insulin secretion  (IEA,ISO,ISS)
negative regulation of mesenchymal stem cell differentiation  (ISO)
negative regulation of miRNA transcription  (IEA,ISO)
negative regulation of neurogenesis  (ISO,ISS)
negative regulation of neuron differentiation  (IBA,IEA,IMP,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,IMP,ISO,NAS)
nervous system process  (IEA,ISO,ISS)
neuromuscular process controlling balance  (ISO,ISS)
neuron differentiation  (IEP)
neuronal stem cell population maintenance  (ISO,ISS)
positive regulation of apoptotic process  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO,ISS)
positive regulation of neuron differentiation  (ISO,ISS)
positive regulation of programmed cell death  (IMP)
positive regulation of stem cell population maintenance  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IBA,IEA)
regulation of alternative mRNA splicing, via spliceosome  (ISO,ISS)
regulation of DNA-templated transcription  (ISO,ISS)
regulation of gene expression  (ISO)
regulation of osteoblast differentiation  (ISO,ISS)
response to hypoxia  (IEA,ISO,ISS)
response to ischemia  (IDA,IEP)
somatic stem cell population maintenance  (ISO,ISS)

Cellular Component
chromatin  (IDA)
cytoplasm  (IEA,ISO,ISS)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO,ISS)
protein-containing complex  (IDA)
transcription repressor complex  (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Regulation of neuronal traits by a novel transcriptional complex. Ballas N, etal., Neuron. 2001 Aug 16;31(3):353-65.
2. Ischemic insults derepress the gene silencer REST in neurons destined to die. Calderone A, etal., J Neurosci 2003 Mar 15;23(6):2112-21.
3. REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Chong JA, etal., Cell. 1995 Mar 24;80(6):949-57.
4. miR-29a modulates neuronal differentiation through targeting REST in mesenchymal stem cells. Duan P, etal., PLoS One. 2014 May 19;9(5):e97684. doi: 10.1371/journal.pone.0097684. eCollection 2014.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes. Hata L, etal., J Mol Cell Cardiol. 2011 Jun;50(6):972-81. doi: 10.1016/j.yjmcc.2011.01.017. Epub 2011 Jan 31.
8. Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. Huang Y, etal., Nat Neurosci. 1999 Oct;2(10):867-72.
9. The gene silencing transcription factor REST represses miR-132 expression in hippocampal neurons destined to die. Hwang JY, etal., J Mol Biol. 2014 Oct 9;426(20):3454-66. doi: 10.1016/j.jmb.2014.07.032. Epub 2014 Aug 6.
10. Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene. Kim CS, etal., Nucleic Acids Res. 2006;34(22):6392-403. Epub 2006 Nov 27.
11. Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Lunyak VV, etal., Science 2002 Nov 29;298(5599):1747-52.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death. Noh KM, etal., Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):E962-71. doi: 10.1073/pnas.1121568109. Epub 2012 Feb 27.
15. Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. Palm K, etal., J Neurosci 1998 Feb 15;18(4):1280-96.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. REST/NRSF governs the expression of dense-core vesicle gliosecretion in astrocytes. Prada I, etal., J Cell Biol. 2011 May 2;193(3):537-49. doi: 10.1083/jcb.201010126.
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors. Rodenas-Ruano A, etal., Nat Neurosci. 2012 Oct;15(10):1382-90. doi: 10.1038/nn.3214. Epub 2012 Sep 9.
21. Protein kinase A regulates cholinergic gene expression in PC12 cells: REST4 silences the silencing activity of neuron-restrictive silencer factor/REST. Shimojo M, etal., Mol Cell Biol. 1999 Oct;19(10):6788-95.
22. Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor. Somekawa S, etal., Endocrinology. 2009 Jul;150(7):3110-7. Epub 2009 Apr 2.
Additional References at PubMed
PMID:8568247   PMID:9771705   PMID:10449787   PMID:10734093   PMID:11039732   PMID:11741002   PMID:11779185   PMID:14565956   PMID:14645515   PMID:15200951   PMID:15240883   PMID:15322094  
PMID:15907476   PMID:15959844   PMID:16417580   PMID:16442230   PMID:16684532   PMID:16828291   PMID:16945103   PMID:17011572   PMID:17064356   PMID:17371849   PMID:17403776   PMID:17555596  
PMID:17984088   PMID:18298477   PMID:18485095   PMID:18570921   PMID:19439607   PMID:19457133   PMID:19923298   PMID:20078938   PMID:20171735   PMID:20564196   PMID:20604903   PMID:20942606  
PMID:21046448   PMID:21068306   PMID:21139978   PMID:21179468   PMID:21199191   PMID:21252229   PMID:21258371   PMID:21368059   PMID:21884984   PMID:22431737   PMID:22780989   PMID:23069678  
PMID:24029230   PMID:24670762   PMID:25117540   PMID:25569790   PMID:25838543   PMID:26674869   PMID:26919115   PMID:26996236   PMID:27531581   PMID:27819263   PMID:29024663   PMID:29961578  
PMID:30039336   PMID:30327427   PMID:30684677   PMID:30914322   PMID:31403159   PMID:32151715   PMID:33185010  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21430,859,109 - 30,879,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1430,862,553 - 30,894,354 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1431,239,986 - 31,260,061 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,548,313 - 32,568,388 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01431,032,969 - 31,053,042 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,131,985 - 33,152,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,134,511 - 33,164,141 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01432,925,741 - 32,951,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41433,136,046 - 33,151,142 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11433,136,045 - 33,151,142 (-)NCBI
Celera1430,181,687 - 30,196,879 (-)NCBICelera
Cytogenetic Map14p11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38456,907,900 - 56,935,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl456,907,876 - 56,966,808 (+)EnsemblGRCh38hg38GRCh38
GRCh37457,774,066 - 57,802,010 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36457,468,799 - 57,493,097 (+)NCBINCBI36Build 36hg18NCBI36
Build 34457,614,969 - 57,639,268NCBI
Celera455,279,985 - 55,307,950 (+)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,727,986 - 53,755,535 (+)NCBIHuRef
CHM1_1457,809,465 - 57,837,418 (+)NCBICHM1_1
T2T-CHM13v2.0460,399,324 - 60,427,254 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39577,413,273 - 77,434,279 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,413,338 - 77,434,279 (+)EnsemblGRCm39 Ensembl
GRCm38577,265,494 - 77,286,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl577,265,491 - 77,286,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv37577,694,519 - 77,712,722 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36578,342,716 - 78,357,759 (+)NCBIMGSCv36mm8
Celera574,535,211 - 74,550,959 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.61NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1473,046,074 - 73,073,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0466,984,466 - 67,012,301 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1473,556,780 - 73,582,419 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl473,526,085 - 73,582,242 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11349,041,082 - 49,062,596 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1349,041,047 - 49,059,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1348,930,954 - 48,953,349 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01349,654,746 - 49,677,219 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,656,727 - 49,673,995 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11349,327,159 - 49,349,567 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,856,606 - 48,878,993 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,801,275 - 49,823,781 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440528527,258,819 - 27,303,941 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648219,018,454 - 19,040,438 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl856,035,150 - 56,215,013 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1856,035,182 - 56,061,140 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2857,440,573 - 57,466,453 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1711,749,312 - 11,776,103 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl711,749,168 - 11,773,340 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606612,388,814 - 12,415,743 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462476112,464,243 - 12,495,294 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Rest
70 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:291
Count of miRNA genes:194
Interacting mature miRNAs:218
Transcripts:ENSRNOT00000002837, ENSRNOT00000002844, ENSRNOT00000064627
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143076702539153750Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21430,864,090 - 30,864,736 (+)MAPPERmRatBN7.2
Rnor_6.01433,136,967 - 33,137,612NCBIRnor6.0
Rnor_5.01432,930,723 - 32,931,368UniSTSRnor5.0
RGSC_v3.41433,137,600 - 33,138,245UniSTSRGSC3.4
Celera1430,183,241 - 30,183,886UniSTS
Cytogenetic Map14p11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 28 33 17 19 17 2 2 29 28 35 11 2
Low 2 14 24 24 24 6 9 45 7 6 6
Below cutoff 1


RefSeq Acc Id: ENSRNOT00000002837   ⟹   ENSRNOP00000002837
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1430,862,553 - 30,878,297 (-)Ensembl
Rnor_6.0 Ensembl1433,135,413 - 33,150,509 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000002844   ⟹   ENSRNOP00000002844
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1430,862,553 - 30,894,354 (-)Ensembl
Rnor_6.0 Ensembl1433,134,511 - 33,164,141 (-)Ensembl
RefSeq Acc Id: NM_031788   ⟹   NP_113976
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21430,859,109 - 30,879,148 (-)NCBI
Rnor_6.01433,135,413 - 33,150,509 (-)NCBI
Rnor_5.01432,925,741 - 32,951,551 (-)NCBI
RGSC_v3.41433,136,046 - 33,151,142 (-)RGD
Celera1430,181,687 - 30,196,879 (-)RGD
RefSeq Acc Id: XM_006250849   ⟹   XP_006250911
Rat AssemblyChrPosition (strand)Source
mRatBN7.21430,859,109 - 30,878,983 (-)NCBI
Rnor_6.01433,131,985 - 33,151,920 (-)NCBI
Rnor_5.01432,925,741 - 32,951,551 (-)NCBI
RefSeq Acc Id: XM_039092503   ⟹   XP_038948431
Rat AssemblyChrPosition (strand)Source
mRatBN7.21430,859,109 - 30,879,828 (-)NCBI
RefSeq Acc Id: NP_113976   ⟸   NM_031788
- UniProtKB: F1M9A3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250911   ⟸   XM_006250849
- Peptide Label: isoform X1
- UniProtKB: F1M9A3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002844   ⟸   ENSRNOT00000002844
RefSeq Acc Id: ENSRNOP00000002837   ⟸   ENSRNOT00000002837
RefSeq Acc Id: XP_038948431   ⟸   XM_039092503
- Peptide Label: isoform X1
- UniProtKB: F1M9A3 (UniProtKB/TrEMBL)
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54963-F1-model_v2 AlphaFold O54963 1-1069 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621069 AgrOrtholog
BioCyc Gene G2FUF-15990 BioCyc
Ensembl Genes ENSRNOG00000002074 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002837 ENTREZGENE
  ENSRNOT00000002837.7 UniProtKB/TrEMBL
  ENSRNOT00000002844.6 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83618 UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rest PhenoGen
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002074 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REST_RAT UniProtKB/Swiss-Prot
UniProt Secondary O54964 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Rest  RE1-silencing transcription factor    zinc finger transcription factor REST protein  Name updated 1299863 APPROVED
2002-08-07 Rest  zinc finger transcription factor REST protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mRNA and protein expression are induced by global ischemia 1299303
gene_expression expression decreases during neuronal development 633753
gene_transcript has several splicing forms with mRNAs encoding proteins with nine, five, or four zinc finger motifs 633753