REST (RE1 silencing transcription factor) - Rat Genome Database

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Pathways
Gene: REST (RE1 silencing transcription factor) Pan paniscus
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Symbol: REST
Name: RE1 silencing transcription factor
RGD ID: 11837564
Description: ENCODES a protein that exhibits DNA binding (ortholog); identical protein binding (ortholog); promoter-specific chromatin binding (ortholog); INVOLVED IN auditory receptor cell stereocilium organization (ortholog); cellular response to stress (ortholog); chromatin remodeling (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); alcohol use disorder (ortholog); autosomal dominant nonsyndromic deafness 27 (ortholog); FOUND IN chromatin (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: RE1-silencing transcription factor
RGD Orthologs
Human
Mouse
Rat
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2372,840,537 - 72,868,421 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1473,046,074 - 73,073,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0466,984,466 - 67,012,301 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1473,556,780 - 73,582,419 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl473,526,085 - 73,582,242 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
auditory receptor cell stereocilium organization  (ISO)
cardiac muscle cell myoblast differentiation  (IEA)
cellular response to electrical stimulus  (IEA)
cellular response to glucocorticoid stimulus  (IEA)
cellular response to stress  (ISO)
chromatin remodeling  (ISO)
detection of mechanical stimulus involved in sensory perception of sound  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
host-mediated suppression of viral transcription  (IEA)
modification of synaptic structure  (ISO)
negative regulation of aldosterone biosynthetic process  (IEA)
negative regulation of amniotic stem cell differentiation  (IEA)
negative regulation of calcium ion-dependent exocytosis  (ISO)
negative regulation of cortisol biosynthetic process  (IEA)
negative regulation of dense core granule biogenesis  (ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of gene expression  (IEA)
negative regulation of insulin secretion  (IEA)
negative regulation of mesenchymal stem cell differentiation  (IEA)
negative regulation of miRNA transcription  (IEA)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
nervous system process  (IEA)
neuromuscular process controlling balance  (ISO)
neuron differentiation  (ISO)
neuronal stem cell population maintenance  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of neuron differentiation  (IEA)
positive regulation of programmed cell death  (ISO)
positive regulation of stem cell population maintenance  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
regulation of alternative mRNA splicing, via spliceosome  (IEA)
regulation of DNA-templated transcription  (ISO)
regulation of gene expression  (IEA,ISO)
regulation of osteoblast differentiation  (IEA)
response to ethanol  (ISO)
response to hypoxia  (IEA)
response to ischemia  (ISO)
response to stress  (IEA)
somatic stem cell population maintenance  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
REST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2372,840,537 - 72,868,421 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1473,046,074 - 73,073,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0466,984,466 - 67,012,301 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1473,556,780 - 73,582,419 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl473,526,085 - 73,582,242 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
REST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38456,907,900 - 56,935,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl456,907,853 - 56,967,011 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37457,774,066 - 57,802,010 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36457,468,799 - 57,493,097 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34457,614,969 - 57,639,268NCBI
Celera455,279,985 - 55,307,950 (+)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,727,986 - 53,755,535 (+)NCBIHuRef
CHM1_1457,809,465 - 57,837,418 (+)NCBICHM1_1
T2T-CHM13v2.0460,399,324 - 60,427,254 (+)NCBIT2T-CHM13v2.0
Rest
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,413,273 - 77,434,279 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,408,131 - 77,434,284 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38577,265,494 - 77,286,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl577,265,491 - 77,286,432 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37577,694,519 - 77,712,722 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36578,342,716 - 78,357,759 (+)NCBIMGSCv36mm8
Celera574,535,211 - 74,550,959 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.61NCBI
Rest
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,213,415 - 31,233,451 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1431,213,415 - 31,248,662 (-)EnsemblGRCr8
mRatBN7.21430,859,109 - 30,879,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1430,862,553 - 30,894,354 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1431,239,986 - 31,260,061 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,548,313 - 32,568,388 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01431,032,969 - 31,053,042 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1431,526,055 - 31,546,127 (-)NCBI
Lyon_Normotensive1431,641,588 - 31,661,660 (-)NCBI
Lyon_Hypertensive1431,638,660 - 31,658,733 (-)NCBI
F344_StmMcwi1431,651,219 - 31,671,295 (-)NCBI
Rnor_6.01433,131,985 - 33,152,019 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,134,511 - 33,164,141 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01432,925,741 - 32,951,551 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41433,136,046 - 33,151,142 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1430,181,687 - 30,196,879 (-)NCBICelera
RGSC_v3.11433,136,045 - 33,151,142 (-)NCBI
Cytogenetic Map14p11NCBI
REST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11349,041,082 - 49,062,596 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1349,041,047 - 49,059,388 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1348,930,954 - 48,953,349 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01349,654,746 - 49,677,219 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,656,727 - 49,673,995 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11349,327,159 - 49,349,567 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,856,606 - 48,878,993 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,801,275 - 49,823,781 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rest
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1941,683,589 - 41,710,909 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440528527,258,819 - 27,303,941 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648219,018,425 - 19,032,901 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648219,018,454 - 19,040,438 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl856,035,150 - 56,215,013 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1856,035,182 - 56,061,140 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2857,440,573 - 57,466,453 (-)NCBISscrofa10.2Sscrofa10.2susScr3
REST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1712,310,325 - 12,337,258 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366606612,388,814 - 12,415,743 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1711,749,312 - 11,776,103 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl711,749,168 - 11,773,340 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Rest
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476112,464,243 - 12,495,294 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rest
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11134,025,892 - 34,046,092 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000004676   ⟹   ENSPPAP00000001010
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl473,526,085 - 73,580,778 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000004679   ⟹   ENSPPAP00000001013
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl473,526,085 - 73,580,778 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000004852   ⟹   ENSPPAP00000001046
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl473,556,780 - 73,582,242 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000004951   ⟹   ENSPPAP00000001063
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl473,560,982 - 73,580,778 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000004982   ⟹   ENSPPAP00000001069
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl473,564,480 - 73,580,778 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000005017   ⟹   ENSPPAP00000001073
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl473,567,777 - 73,580,778 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000005055   ⟹   ENSPPAP00000001078
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl473,572,407 - 73,580,778 (-)Ensembl
RefSeq Acc Id: XM_003806496   ⟹   XP_003806544
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2372,840,537 - 72,867,381 (-)NCBI
NHGRI_mPanPan1473,046,074 - 73,072,925 (-)NCBI
Mhudiblu_PPA_v0466,984,466 - 67,011,316 (-)NCBI
PanPan1.1473,556,780 - 73,582,419 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008954472   ⟹   XP_008952720
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2372,840,537 - 72,867,009 (-)NCBI
NHGRI_mPanPan1473,046,074 - 73,072,551 (-)NCBI
Mhudiblu_PPA_v0466,984,466 - 67,011,924 (-)NCBI
PanPan1.1473,556,780 - 73,582,240 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008954475   ⟹   XP_008952723
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2372,840,537 - 72,867,183 (-)NCBI
NHGRI_mPanPan1473,046,074 - 73,072,729 (-)NCBI
Mhudiblu_PPA_v0466,984,466 - 67,011,108 (-)NCBI
PanPan1.1473,556,780 - 73,582,268 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034958759   ⟹   XP_034814650
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2372,840,537 - 72,868,421 (-)NCBI
NHGRI_mPanPan1473,046,074 - 73,073,965 (-)NCBI
Mhudiblu_PPA_v0466,984,466 - 67,012,301 (-)NCBI
RefSeq Acc Id: XM_055111520   ⟹   XP_054967495
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2372,840,537 - 72,867,381 (-)NCBI
NHGRI_mPanPan1473,046,074 - 73,072,925 (-)NCBI
RefSeq Acc Id: XM_063603810   ⟹   XP_063459880
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2372,840,537 - 72,868,408 (-)NCBI
RefSeq Acc Id: XP_003806544   ⟸   XM_003806496
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZEK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008952723   ⟸   XM_008954475
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZEK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008952720   ⟸   XM_008954472
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZEK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034814650   ⟸   XM_034958759
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZEK2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000001073   ⟸   ENSPPAT00000005017
Ensembl Acc Id: ENSPPAP00000001078   ⟸   ENSPPAT00000005055
Ensembl Acc Id: ENSPPAP00000001013   ⟸   ENSPPAT00000004679
Ensembl Acc Id: ENSPPAP00000001010   ⟸   ENSPPAT00000004676
Ensembl Acc Id: ENSPPAP00000001046   ⟸   ENSPPAT00000004852
Ensembl Acc Id: ENSPPAP00000001063   ⟸   ENSPPAT00000004951
Ensembl Acc Id: ENSPPAP00000001069   ⟸   ENSPPAT00000004982
RefSeq Acc Id: XP_054967495   ⟸   XM_055111520
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZEK2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063459880   ⟸   XM_063603810
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZEK2 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000004172 Ensembl, UniProtKB/TrEMBL
  ENSPPAG00050008183 ENTREZGENE
Ensembl Transcript ENSPPAT00000004676.1 UniProtKB/TrEMBL
  ENSPPAT00000004679.1 UniProtKB/TrEMBL
  ENSPPAT00000004852.1 UniProtKB/TrEMBL
  ENSPPAT00000004951.1 UniProtKB/TrEMBL
  ENSPPAT00000004982.1 UniProtKB/TrEMBL
  ENSPPAT00000005017.1 UniProtKB/TrEMBL
  ENSPPAT00000005055.1 UniProtKB/TrEMBL
  ENSPPAT00050017598 ENTREZGENE
  ENSPPAT00050017606 ENTREZGENE
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Zfn-C2H2_REST UniProtKB/TrEMBL
  Zinc_finger/UBP_domain UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report pps:100968041 UniProtKB/TrEMBL
NCBI Gene REST ENTREZGENE
PANTHER RE1-SILENCING TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_REST UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A2R8Z7Z0_PANPA UniProtKB/TrEMBL
  A0A2R8Z840_PANPA UniProtKB/TrEMBL
  A0A2R8Z849_PANPA UniProtKB/TrEMBL
  A0A2R8Z856_PANPA UniProtKB/TrEMBL
  A0A2R8Z8B5_PANPA UniProtKB/TrEMBL
  A0A2R8ZBW4_PANPA UniProtKB/TrEMBL
  A0A2R8ZEK2 ENTREZGENE, UniProtKB/TrEMBL