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Gene: Rest (RE1-silencing transcription factor) Mus musculus
Symbol: Rest
Name: RE1-silencing transcription factor
RGD ID: 732239
Description: Exhibits several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of sound; generation of neurons; and regulation of gene expression. Localizes to cytosol; nucleus; and transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and peripheral nervous system ganglion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor); PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 5-fluorouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2610008J04Rik; AA407358; D14Mgi1; MGC150099; N; neural-restrictive silencer factor; NRSF; REST/NRSF; REST4
Homo sapiens (human) : REST (RE1 silencing transcription factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rest (RE1-silencing transcription factor)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : REST (RE1 silencing transcription factor)
Canis lupus familiaris (dog) : REST (RE1 silencing transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rest (RE1 silencing transcription factor)
Sus scrofa (pig) : REST (RE1 silencing transcription factor)
Chlorocebus sabaeus (African green monkey) : REST (RE1 silencing transcription factor)
Heterocephalus glaber (naked mole-rat) : Rest (RE1 silencing transcription factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39577,413,273 - 77,434,279 (+)NCBI
GRCm38577,265,494 - 77,286,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl577,265,491 - 77,286,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv37577,694,519 - 77,712,722 (+)NCBIGRCm37mm9NCBIm37
MGSCv36578,342,716 - 78,357,759 (+)NCBImm8
Celera574,535,211 - 74,550,959 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Rest
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732239
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.