REST (RE1 silencing transcription factor) - Rat Genome Database

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Gene: REST (RE1 silencing transcription factor) Canis lupus familiaris
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Symbol: REST
Name: RE1 silencing transcription factor
RGD ID: 12116220
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN auditory receptor cell stereocilium organization (ortholog); cardiac muscle cell myoblast differentiation (ortholog); cellular response to electrical stimulus (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 27 (ortholog); genetic disease (ortholog); Gingival Fibromatosis 1 (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: RE1-silencing transcription factor
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11349,041,082 - 49,062,596 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1349,041,047 - 49,059,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1348,930,954 - 48,953,349 (+)NCBI
ROS_Cfam_1.01349,654,746 - 49,677,219 (+)NCBI
UMICH_Zoey_3.11349,327,159 - 49,349,567 (+)NCBI
UNSW_CanFamBas_1.01348,856,606 - 48,878,993 (+)NCBI
UU_Cfam_GSD_1.01349,801,275 - 49,823,781 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
auditory receptor cell stereocilium organization  (ISO)
cardiac muscle cell myoblast differentiation  (ISS)
cellular response to electrical stimulus  (ISS)
cellular response to glucocorticoid stimulus  (ISS)
cellular response to xenobiotic stimulus  (ISS)
detection of mechanical stimulus involved in sensory perception of sound  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
histone H4 deacetylation  (ISS)
modification of synaptic structure  (ISO)
negative regulation by host of viral transcription  (ISS)
negative regulation of aldosterone biosynthetic process  (ISS)
negative regulation of amniotic stem cell differentiation  (ISS)
negative regulation of calcium ion-dependent exocytosis  (ISS)
negative regulation of cell population proliferation  (ISS)
negative regulation of cortisol biosynthetic process  (ISS)
negative regulation of dense core granule biogenesis  (ISS)
negative regulation of gene expression  (ISS)
negative regulation of insulin secretion  (ISS)
negative regulation of mesenchymal stem cell differentiation  (ISO)
negative regulation of neurogenesis  (ISO,ISS)
negative regulation of neuron differentiation  (ISO,ISS)
negative regulation of oxidative stress-induced neuron death  (ISO)
negative regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transcription regulatory region DNA binding  (ISO)
negative regulation of transcription, DNA-templated  (ISO,ISS)
neuromuscular process controlling balance  (ISO)
neuron differentiation  (ISO)
neuronal stem cell population maintenance  (ISO)
positive regulation of apoptotic process  (ISS)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISS)
positive regulation of gene expression  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of oxidative stress-induced neuron death  (ISO)
positive regulation of stem cell population maintenance  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of alternative mRNA splicing, via spliceosome  (ISO)
regulation of gene expression  (ISO)
regulation of osteoblast differentiation  (ISO)
regulation of oxidative stress-induced neuron death  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
somatic stem cell population maintenance  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
REST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11349,041,082 - 49,062,596 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1349,041,047 - 49,059,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1348,930,954 - 48,953,349 (+)NCBI
ROS_Cfam_1.01349,654,746 - 49,677,219 (+)NCBI
UMICH_Zoey_3.11349,327,159 - 49,349,567 (+)NCBI
UNSW_CanFamBas_1.01348,856,606 - 48,878,993 (+)NCBI
UU_Cfam_GSD_1.01349,801,275 - 49,823,781 (+)NCBI
REST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl456,907,876 - 56,966,808 (+)EnsemblGRCh38hg38GRCh38
GRCh38456,907,900 - 56,935,847 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37457,774,066 - 57,802,010 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36457,468,799 - 57,493,097 (+)NCBINCBI36hg18NCBI36
Build 34457,614,969 - 57,639,268NCBI
Celera455,279,985 - 55,307,950 (+)NCBI
Cytogenetic Map4q12NCBI
HuRef453,727,986 - 53,755,535 (+)NCBIHuRef
CHM1_1457,809,465 - 57,837,418 (+)NCBICHM1_1
Rest
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,413,273 - 77,434,279 (+)NCBIGRCm39mm39
GRCm39 Ensembl577,413,338 - 77,434,279 (+)Ensembl
GRCm38577,265,494 - 77,286,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl577,265,491 - 77,286,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv37577,694,519 - 77,712,722 (+)NCBIGRCm37mm9NCBIm37
MGSCv36578,342,716 - 78,357,759 (+)NCBImm8
Celera574,535,211 - 74,550,959 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
Rest
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21430,859,109 - 30,879,828 (-)NCBI
Rnor_6.0 Ensembl1433,134,511 - 33,164,141 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01433,131,985 - 33,152,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01432,925,741 - 32,951,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41433,136,046 - 33,151,142 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11433,136,045 - 33,151,142 (-)NCBI
Celera1430,181,687 - 30,196,879 (-)NCBICelera
Cytogenetic Map14p11NCBI
REST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1473,556,780 - 73,582,419 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl473,526,085 - 73,582,242 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0466,984,466 - 67,012,301 (-)NCBIMhudiblu_PPA_v0panPan3
Rest
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,258,819 - 27,303,941 (-)NCBI
SpeTri2.0NW_00493648219,018,454 - 19,040,438 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl856,035,150 - 56,215,013 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1856,035,182 - 56,061,140 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2857,440,573 - 57,466,453 (-)NCBISscrofa10.2Sscrofa10.2susScr3
REST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1711,749,312 - 11,776,103 (-)NCBI
ChlSab1.1 Ensembl711,749,168 - 11,773,340 (-)Ensembl
Vero_WHO_p1.0NW_02366606612,388,814 - 12,415,743 (-)NCBI
Rest
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476112,464,243 - 12,495,294 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 5
Low 5 5 18 6 6 6 6 6 12 8 5 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038425956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038425962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038425970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038493877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038493878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038493879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038493880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038685736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_539282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000003537   ⟹   ENSCAFP00000003276
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1349,042,922 - 49,059,388 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000024004   ⟹   ENSCAFP00000022285
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1349,041,047 - 49,050,295 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000078786   ⟹   ENSCAFP00000050282
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1349,041,047 - 49,055,962 (+)Ensembl
RefSeq Acc Id: XM_038425956   ⟹   XP_038281884
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1348,931,807 - 48,953,349 (+)NCBI
RefSeq Acc Id: XM_038425962   ⟹   XP_038281890
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1348,932,699 - 48,953,349 (+)NCBI
RefSeq Acc Id: XM_038425970   ⟹   XP_038281898
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1348,930,954 - 48,953,349 (+)NCBI
RefSeq Acc Id: XM_038493877   ⟹   XP_038349805
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11349,328,045 - 49,349,567 (+)NCBI
RefSeq Acc Id: XM_038493878   ⟹   XP_038349806
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11349,328,006 - 49,349,567 (+)NCBI
RefSeq Acc Id: XM_038493879   ⟹   XP_038349807
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11349,328,900 - 49,349,567 (+)NCBI
RefSeq Acc Id: XM_038493880   ⟹   XP_038349808
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11349,327,159 - 49,349,567 (+)NCBI
RefSeq Acc Id: XM_038556183   ⟹   XP_038412111
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01349,801,275 - 49,823,781 (+)NCBI
RefSeq Acc Id: XM_038556184   ⟹   XP_038412112
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01349,802,157 - 49,823,781 (+)NCBI
RefSeq Acc Id: XM_038556185   ⟹   XP_038412113
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01349,802,118 - 49,823,781 (+)NCBI
RefSeq Acc Id: XM_038556186   ⟹   XP_038412114
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01349,803,013 - 49,823,781 (+)NCBI
RefSeq Acc Id: XM_038620115   ⟹   XP_038476043
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01348,857,489 - 48,878,993 (+)NCBI
RefSeq Acc Id: XM_038620116   ⟹   XP_038476044
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01348,857,450 - 48,878,993 (+)NCBI
RefSeq Acc Id: XM_038620117   ⟹   XP_038476045
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01348,858,331 - 48,878,993 (+)NCBI
RefSeq Acc Id: XM_038620118   ⟹   XP_038476046
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01348,856,606 - 48,878,993 (+)NCBI
RefSeq Acc Id: XM_038685733   ⟹   XP_038541661
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01349,655,635 - 49,677,219 (+)NCBI
RefSeq Acc Id: XM_038685734   ⟹   XP_038541662
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01349,655,596 - 49,677,219 (+)NCBI
RefSeq Acc Id: XM_038685735   ⟹   XP_038541663
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01349,656,492 - 49,677,219 (+)NCBI
RefSeq Acc Id: XM_038685736   ⟹   XP_038541664
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01349,654,746 - 49,677,219 (+)NCBI
RefSeq Acc Id: XM_539282   ⟹   XP_539282
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11349,041,082 - 49,062,596 (+)NCBI
Dog10K_Boxer_Tasha1348,931,846 - 48,953,349 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_539282   ⟸   XM_539282
- UniProtKB: F1PP47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000050282   ⟸   ENSCAFT00000078786
RefSeq Acc Id: ENSCAFP00000022285   ⟸   ENSCAFT00000024004
RefSeq Acc Id: ENSCAFP00000003276   ⟸   ENSCAFT00000003537
RefSeq Acc Id: XP_038349808   ⟸   XM_038493880
RefSeq Acc Id: XP_038349806   ⟸   XM_038493878
RefSeq Acc Id: XP_038349805   ⟸   XM_038493877
RefSeq Acc Id: XP_038349807   ⟸   XM_038493879
RefSeq Acc Id: XP_038476046   ⟸   XM_038620118
RefSeq Acc Id: XP_038476044   ⟸   XM_038620116
RefSeq Acc Id: XP_038476043   ⟸   XM_038620115
RefSeq Acc Id: XP_038476045   ⟸   XM_038620117
RefSeq Acc Id: XP_038541664   ⟸   XM_038685736
RefSeq Acc Id: XP_038541662   ⟸   XM_038685734
RefSeq Acc Id: XP_038541661   ⟸   XM_038685733
RefSeq Acc Id: XP_038541663   ⟸   XM_038685735
RefSeq Acc Id: XP_038281898   ⟸   XM_038425970
RefSeq Acc Id: XP_038281884   ⟸   XM_038425956
RefSeq Acc Id: XP_038281890   ⟸   XM_038425962
RefSeq Acc Id: XP_038412111   ⟸   XM_038556183
RefSeq Acc Id: XP_038412113   ⟸   XM_038556185
RefSeq Acc Id: XP_038412112   ⟸   XM_038556184
RefSeq Acc Id: XP_038412114   ⟸   XM_038556186
Protein Domains
C2H2-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002254 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000003276 ENTREZGENE
NCBI Gene REST ENTREZGENE
UniProt F1PP47 ENTREZGENE
VGNC ID VGNC:45480 ENTREZGENE