RGD Reference Report - Regulation of neuronal traits by a novel transcriptional complex. - Rat Genome Database

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Regulation of neuronal traits by a novel transcriptional complex.

Authors: Ballas, N  Battaglioli, E  Atouf, F  Andres, ME  Chenoweth, J  Anderson, ME  Burger, C  Moniwa, M  Davie, JR  Bowers, WJ  Federoff, HJ  Rose, DW  Rosenfeld, MG  Brehm, P  Mandel, G 
Citation: Ballas N, etal., Neuron. 2001 Aug 16;31(3):353-65.
RGD ID: 2306452
Pubmed: PMID:11516394   (View Abstract at PubMed)

The transcriptional repressor, REST, helps restrict neuronal traits to neurons by blocking their expression in nonneuronal cells. To examine the repercussions of REST expression in neurons, we generated a neuronal cell line that expresses REST conditionally. REST expression inhibited differentiation by nerve growth factor, suppressing both sodium current and neurite growth. A novel corepressor complex, CoREST/HDAC2, was shown to be required for REST repression. In the presence of REST, the CoREST/HDAC2 complex occupied the native Nav1.2 sodium channel gene in chromatin. In neuronal cells that lack REST and express sodium channels, the corepressor complex was not present on the gene. Collectively, these studies define a novel HDAC complex that is recruited by the C-terminal repressor domain of REST to actively repress genes essential to the neuronal phenotype.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Hdac2Ratnegative regulation of DNA-templated transcription  IMP  RGD 
Rcor2Ratnegative regulation of DNA-templated transcription  IMP  RGD 
RestRatnegative regulation of DNA-templated transcription  IMP  RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Hdac2Ratchromatin  IDA  RGD 
Rcor2Ratchromatin  IDA  RGD 
RestRatchromatin  IDA  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Hdac2Ratprotein binding  IPIRcor2 (Rattus norvegicus) RGD 
Rcor2Ratprotein binding  IPIHdac2 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hdac2  (histone deacetylase 2)
Rcor2  (REST corepressor 2)
Rest  (RE1-silencing transcription factor)


Additional Information