RGD Reference Report - Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. - Rat Genome Database

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Corepressor-dependent silencing of chromosomal regions encoding neuronal genes.

Authors: Lunyak, VV  Burgess, R  Prefontaine, GG  Nelson, C  Sze, SH  Chenoweth, J  Schwartz, P  Pevzner, PA  Glass, C  Mandel, G  Rosenfeld, MG 
Citation: Lunyak VV, etal., Science 2002 Nov 29;298(5599):1747-52.
RGD ID: 633754
Pubmed: PMID:12399542   (View Abstract at PubMed)
DOI: DOI:10.1126/science.1076469   (Journal Full-text)

The molecular mechanisms by which central nervous system-specific genes are expressed only in the nervous system and repressed in other tissues remain a central issue in developmental and regulatory biology. Here, we report that the zinc-finger gene-specific repressor element RE-1 silencing transcription factor/neuronal restricted silencing factor (REST/NRSF) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long-term gene silencing using a distinct functional complex. Silencing of neuronal-specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST/NRSF response elements.

Objects referenced in this article
Gene Rest RE1-silencing transcription factor Rattus norvegicus

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