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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2922
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irs1
Name: insulin receptor substrate 1
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects phosphorylationISORGD:7334736480464CTDSirolimus affects the phosphorylation of IRS1 protein

PMID:17908691
decreases degradationISORGD:7334736480464CTDSirolimus results in decreased degradation of IRS1 protein

PMID:16227402, PMID:17908691
decreases phosphorylationISORGD:7334736480464CTDSirolimus results in decreased phosphorylation of IRS1 protein

PMID:16227402
multiple interactionsISORGD:7334736480464CTD[Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased activity of IRS1 protein, Sirolimus inhibits the reaction [cyanoginosin LR promotes the reaction [INS protein results in increased phosphorylation of IRS1 protein]], Sirolimus inhibits the reaction [cyanoginosin LR results in increased phosphorylation of IRS1 protein], Sirolimus inhibits the reaction [INS protein promotes the reaction [cyanoginosin LR results in increased phosphorylation of IRS1 protein]], Sirolimus inhibits the reaction [INS protein results in increased expression of IRS1 protein modified form], Sirolimus inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein], Sirolimus promotes the reaction [IGF1R protein binds to and results in increased phosphorylation of IRS1 protein], Sirolimus promotes the reaction [IRS1 protein binds to PIK3R1 protein]

PMID:16227402, PMID:17908691, PMID:20936651, PMID:28984034
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.