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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDSirolimus results in decreased expression of CCND1 protein

PMID:7532117
multiple interactionsEXP 6480464CTDSirolimus inhibits the reaction [BTC protein results in increased expression of CCND1 protein], Sirolimus inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]

PMID:19105244
decreases expressionISORGD:685566480464CTDSirolimus results in decreased expression of CCND1 protein

PMID:15753396, PMID:17121904, PMID:19505958
increases degradationISORGD:685566480464CTDSirolimus results in increased degradation of CCND1 protein

PMID:15753396
increases expressionISORGD:685566480464CTDSirolimus results in increased expression of CCND1 protein

PMID:19661225
multiple interactionsISORGD:685566480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sirolimus results in increased expression of CCND1 protein], [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3, 2-d)pyrimidine co-treated with Sirolimus] results in decreased expression of CCND1, [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2, 5-dione results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein], [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CCND1 protein, [Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein], [SB 216763 results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein], [Sirolimus co-treated with Letrozole] results in decreased expression of CCND1 protein, [Sirolimus co-treated with tanespimycin] results in decreased expression of CCND1 protein, [Sirolimus results in increased activity of GSK3B protein] which results in increased phosphorylation of and results in increased degradation of CCND1 protein

PMID:15753396, PMID:15767555, PMID:17121904, PMID:19661225, PMID:20054642, PMID:23006739
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.