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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:68478
Term: everolimus
Definition: A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted into the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent.
Chemical ID: MESH:C107135
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects response to substanceISOABCB1 (Homo sapiens)6480464CTDABCB1 polymorphism affects the susceptibility to EverolimusPMID:27169792
Abcb1aaffects stabilityISOAbcb1a (Mus musculus)6480464CTDABCB1A protein affects the stability of EverolimusPMID:24727322
Abcb1amultiple interactionsISOAbcb1a (Mus musculus)6480464CTDbis(4-nitrophenyl)phosphate inhibits the reaction [ABCB1A protein affects the stability of Everolimus]; Everolimus inhibits the reaction [ABCB1A protein affects the metabolism of irinotecan]PMID:24727322
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