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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ridaforolimus
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Accession:CHEBI:82677 term browser browse the term
Definition:A semisynthetic derivative that is sirolimus in which the hydroxy group attached to the cyclohexyl moiety has been converted to the corresponding dimethylphosphinate.
Synonyms:exact_synonym: (1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl dimethylphosphinate
 related_synonym: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-12-((1R)-2-((1S,3R,4R)-4-((dimethylphosphinoyl)oxy)-3-methoxycyclohexyl)-1-methylethyl)-1,18- dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4- azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene- 2,3,10,14,20-pentone;   42-(dimethylphosphinate)rapamycin;   AP 23573;   AP23573;   Formula=C53H84NO14P;   InChI=1S/C53H84NO14P/c1-32-18-14-13-15-19-33(2)44(63-8)30-40-23-21-38(7)53(61,67-40)50(58)51(59)54-25-17-16-20-41(54)52(60)66-45(35(4)28-39-22-24-43(46(29-39)64-9)68-69(11,12)62)31-42(55)34(3)27-37(6)48(57)49(65-10)47(56)36(5)26-32/h13-15,18-19,27,32,34-36,38-41,43-46,48-49,57,61H,16-17,20-26,28-31H2,1-12H3/b15-13+,18-14+,33-19+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49?,53-/m1/s1;   InChIKey=BUROJSBIWGDYCN-QSRQGROMSA-N;   MK 8669;   SMILES=CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\\C=C(C)\\[C@@H](O)C(OC)C(=O)[C@H](C)C[C@H](C)\\C=C\\C=C\\C=C(C)\\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1OP(C)(C)=O;   deforolimus;   ridaforolimusum;   sirolimus 42-(dimethylphosphinate)
 xref: CAS:572924-54-0;   KEGG:C15183;   KEGG:D08900
 xref_mesh: MESH:C515074
 xref: PMID:21732754;   PMID:22204929;   PMID:22291080;   Reaxys:11886334;   Wikipedia:Ridaforolimus



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ridaforolimus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO ridaforolimus inhibits the reaction [Radon results in increased expression of ACTA2 protein] CTD PMID:32949624 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ridaforolimus inhibits the reaction [Radon results in decreased expression of CDH1 protein] CTD PMID:32949624 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO ridaforolimus inhibits the reaction [Radon results in increased expression of CDH2 protein] CTD PMID:32949624 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO ridaforolimus inhibits the reaction [Radon results in increased expression of FN1 protein] CTD PMID:32949624 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases activity
ISO ridaforolimus inhibits the reaction [Radon results in increased expression of MTOR protein modified form]
ridaforolimus results in decreased activity of MTOR protein
CTD PMID:32949624 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO ridaforolimus inhibits the reaction [Radon results in increased expression of SNAI1 protein] CTD PMID:32949624 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Vim vimentin multiple interactions ISO ridaforolimus inhibits the reaction [Radon results in increased expression of VIM protein] CTD PMID:32949624 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

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    role 19818
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            antineoplastic agent 17769
              ridaforolimus 7
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    subatomic particle 19809
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                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      carboacyl group 17675
                                        univalent carboacyl group 17675
                                          carbamoyl group 17524
                                            carboxamide 17547
                                              lactam 8380
                                                macrolide lactam 820
                                                  sirolimus 523
                                                    ridaforolimus 7
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