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RGD ID: 620259
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif4ebp1
Name: eukaryotic translation initiation factor 4E binding protein 1
Acc ID: CHEBI:84327
Term: torin 1
Definition: A member of the class of pyridoquinolines that is 9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2-one bearing an additional 4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl substituent at position 1. It is a potent inhibitor of mTOR and exhibits anti-cancer properties.
Chemical ID: MESH:C553294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif4ebp1decreases phosphorylationISORGD:13535006480464CTD1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased phosphorylation of EIF4EBP1 proteinPMID:25940091
Eif4ebp1decreases phosphorylationISORGD:7334426480464CTD1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased phosphorylation of EIF4EBP1 proteinPMID:29945972
Eif4ebp1multiple interactionsISORGD:13535006480464CTD1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one promotes the reaction [EIF4EBP1 protein binds to 7-methylguanosine triphosphate]PMID:25940091
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