Myh11 (myosin heavy chain 11) - Rat Genome Database

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Gene: Myh11 (myosin heavy chain 11) Rattus norvegicus
Analyze
Symbol: Myh11
Name: myosin heavy chain 11
RGD ID: 3136
Description: Predicted to enable cytoskeletal motor activity. Predicted to be a structural constituent of muscle. Predicted to be involved in cardiac muscle cell development and elastic fiber assembly. Predicted to act upstream of or within smooth muscle contraction. Predicted to be located in brush border; smooth muscle contractile fiber; and stress fiber. Predicted to be part of muscle myosin complex. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome; patent ductus arteriosus; and thoracic aortic aneurysm. Orthologous to human MYH11 (myosin heavy chain 11); PARTICIPATES IN myocarditis pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC497849; myosin heavy chain 21; myosin heavy chain, smooth muscle isoform; myosin, heavy chain 11, smooth muscle; myosin, heavy polypeptide 11, smooth muscle; myosin-11; RGD1564935; similar to Myh11 protein; SMMHC; smooth muscle myosin heavy chain
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp133  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210743,364 - 838,459 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl10743,685 - 838,459 (+)Ensembl
Rnor_6.010764,421 - 859,184 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10764,421 - 859,184 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01011,444,263 - 11,538,406 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410666,709 - 776,540 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110767,179 - 776,535 (+)NCBI
Celera1011,333,535 - 11,428,078 (+)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
Brodifacoum  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
corticosterone  (EXP)
cyclosporin A  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dibutyl phthalate  (EXP,ISO)
diuron  (EXP)
doramapimod  (EXP)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
graphite  (EXP)
L-ascorbic acid  (EXP)
losartan  (EXP)
methapyrilene  (ISO)
nickel atom  (ISO)
nifedipine  (EXP,ISO)
nitrofen  (EXP)
paracetamol  (ISO)
pentanal  (ISO)
PhIP  (EXP)
pioglitazone  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
resveratrol  (EXP)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
undecane  (EXP)
urethane  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Identification of a novel smooth muscle myosin heavy chain cDNA: isoform diversity in the S1 head region. White S, etal., Am J Physiol. 1993 May;264(5 Pt 1):C1252-8.
11. Molecular cloning and functional analysis of the promoter region of rat nonmuscle myosin heavy chain-B gene. Yam JW, etal., Biochem Biophys Res Commun 2000 Oct 5;276(3):1203-9.
12. Proteomic analysis of aortic smooth muscle cell secretions reveals an association of myosin heavy chain 11 with abdominal aortic aneurysm. Yokoyama U, etal., Am J Physiol Heart Circ Physiol. 2018 Jul 13. doi: 10.1152/ajpheart.00329.2018.
13. Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. Zhu L, etal., Nat Genet. 2006 Mar;38(3):343-9. Epub 2006 Jan 29.
Additional References at PubMed
PMID:2614841   PMID:8593698   PMID:10854329   PMID:11715025   PMID:12477932   PMID:12562924   PMID:16025302   PMID:17392380   PMID:22114352   PMID:23533145  


Genomics

Candidate Gene Status
Myh11 is a candidate Gene for QTL Vetf10
Comparative Map Data
Myh11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210743,364 - 838,459 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl10743,685 - 838,459 (+)Ensembl
Rnor_6.010764,421 - 859,184 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10764,421 - 859,184 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01011,444,263 - 11,538,406 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410666,709 - 776,540 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110767,179 - 776,535 (+)NCBI
Celera1011,333,535 - 11,428,078 (+)NCBICelera
Cytogenetic Map10q11NCBI
MYH11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381615,703,135 - 15,857,028 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1615,703,135 - 15,857,028 (-)EnsemblGRCh38hg38GRCh38
GRCh371615,796,992 - 15,950,885 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361615,704,493 - 15,858,388 (-)NCBINCBI36hg18NCBI36
Build 341615,704,494 - 15,858,369NCBI
Celera1615,477,469 - 15,631,373 (-)NCBI
Cytogenetic Map16p13.11NCBI
HuRef1615,190,414 - 15,344,394 (-)NCBIHuRef
CHM1_11615,881,372 - 16,035,249 (-)NCBICHM1_1
T2T-CHM13v2.01615,708,067 - 15,861,962 (-)NCBI
Myh11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391614,012,391 - 14,110,052 (-)NCBIGRCm39mm39
GRCm39 Ensembl1614,012,399 - 14,109,236 (-)Ensembl
GRCm381614,194,527 - 14,292,188 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1614,194,535 - 14,291,372 (-)EnsemblGRCm38mm10GRCm38
MGSCv371614,194,620 - 14,291,501 (-)NCBIGRCm37mm9NCBIm37
MGSCv361614,108,478 - 14,204,941 (-)NCBImm8
Celera1614,801,022 - 14,896,521 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.71NCBI
Myh11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955442528,880 - 644,264 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955442528,317 - 644,252 (-)NCBIChiLan1.0ChiLan1.0
MYH11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11616,006,840 - 16,091,058 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1616,007,168 - 16,091,058 (-)Ensemblpanpan1.1panPan2
MYH11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,041,330 - 28,157,277 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,041,318 - 28,262,184 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,405,013 - 29,520,689 (+)NCBI
ROS_Cfam_1.0628,204,726 - 28,320,508 (+)NCBI
ROS_Cfam_1.0 Ensembl628,204,776 - 28,320,502 (+)Ensembl
UMICH_Zoey_3.1628,007,790 - 28,123,460 (+)NCBI
UNSW_CanFamBas_1.0627,898,014 - 28,013,477 (+)NCBI
UU_Cfam_GSD_1.0628,303,247 - 28,418,936 (+)NCBI
Myh11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344115,125,200 - 115,215,681 (-)NCBI
SpeTri2.0NW_0049365013,223,057 - 3,313,487 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYH11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl37,002,733 - 7,143,094 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.137,002,667 - 7,143,093 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MYH11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1514,723,930 - 14,879,390 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl514,725,504 - 14,879,198 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606815,158,855 - 15,315,982 (+)NCBIVero_WHO_p1.0
Myh11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624782270,731 - 354,838 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624782270,183 - 373,711 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D10Rat225  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210772,292 - 772,499 (+)MAPPERmRatBN7.2
Rnor_6.010793,024 - 793,230NCBIRnor6.0
Rnor_5.01011,472,870 - 11,473,076UniSTSRnor5.0
RGSC_v3.410695,259 - 695,466RGDRGSC3.4
RGSC_v3.410695,260 - 695,466UniSTSRGSC3.4
RGSC_v3.110695,139 - 695,513RGD
Celera1011,362,142 - 11,362,348UniSTS
FHH x ACI Map104.54RGD
FHH x ACI Map104.54UniSTS
Cytogenetic Map10q11-q12UniSTS
RH130975  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210838,258 - 838,440 (+)MAPPERmRatBN7.2
Rnor_6.010858,984 - 859,165NCBIRnor6.0
Rnor_5.01011,538,206 - 11,538,387UniSTSRnor5.0
RGSC_v3.410776,340 - 776,521UniSTSRGSC3.4
Celera1011,427,878 - 11,428,059UniSTS
Cytogenetic Map10q11-q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:57
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000044317
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4
Medium 3 42 14 16 8 9 14 23 27 11 8
Low 1 43 41 3 41 2 60 12 10
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000084608   ⟹   ENSRNOP00000074575
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10743,685 - 838,459 (+)Ensembl
Rnor_6.0 Ensembl10764,421 - 859,184 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087567   ⟹   ENSRNOP00000073929
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10743,685 - 838,454 (+)Ensembl
Rnor_6.0 Ensembl10764,430 - 858,894 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112644   ⟹   ENSRNOP00000080001
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10743,685 - 838,454 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115537   ⟹   ENSRNOP00000088033
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10743,685 - 838,459 (+)Ensembl
RefSeq Acc Id: NM_001170600   ⟹   NP_001164071
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210743,685 - 838,459 (+)NCBI
Rnor_6.010764,421 - 859,184 (+)NCBI
Rnor_5.01011,444,263 - 11,538,406 (+)NCBI
Celera1011,333,535 - 11,428,078 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245842   ⟹   XP_006245904
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210743,365 - 838,330 (+)NCBI
Rnor_6.010764,432 - 858,955 (+)NCBI
Rnor_5.01011,444,263 - 11,538,406 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245844   ⟹   XP_006245906
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210743,365 - 838,330 (+)NCBI
Rnor_6.010764,432 - 858,955 (+)NCBI
Rnor_5.01011,444,263 - 11,538,406 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596997   ⟹   XP_017452486
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210743,365 - 838,457 (+)NCBI
Rnor_6.010764,432 - 858,955 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596998   ⟹   XP_017452487
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210743,364 - 838,457 (+)NCBI
Rnor_6.010776,713 - 859,182 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085198   ⟹   XP_038941126
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210743,365 - 838,457 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001164071   ⟸   NM_001170600
- UniProtKB: E9PTU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245904   ⟸   XM_006245842
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6S9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245906   ⟸   XM_006245844
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6S9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452486   ⟸   XM_017596997
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6S9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452487   ⟸   XM_017596998
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000074575   ⟸   ENSRNOT00000084608
RefSeq Acc Id: ENSRNOP00000073929   ⟸   ENSRNOT00000087567
RefSeq Acc Id: XP_038941126   ⟸   XM_039085198
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000088033   ⟸   ENSRNOT00000115537
RefSeq Acc Id: ENSRNOP00000080001   ⟸   ENSRNOT00000112644
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63862-F1-model_v2 AlphaFold Q63862 1-1327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696924
Promoter ID:EPDNEW_R7446
Type:single initiation site
Name:Myh11_1
Description:myosin heavy chain 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010764,465 - 764,525EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
10 852063 852064 C T snv CDR


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3136 AgrOrtholog
BioCyc Gene G2FUF-26258 BioCyc
Ensembl Genes ENSRNOG00000057880 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000073929 ENTREZGENE
  ENSRNOP00000073929.2 UniProtKB/TrEMBL
  ENSRNOP00000074575 ENTREZGENE
  ENSRNOP00000074575.2 UniProtKB/TrEMBL
  ENSRNOP00000080001 ENTREZGENE
  ENSRNOP00000080001.1 UniProtKB/TrEMBL
  ENSRNOP00000088033 ENTREZGENE
  ENSRNOP00000088033.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084608 ENTREZGENE
  ENSRNOT00000084608.2 UniProtKB/TrEMBL
  ENSRNOT00000087567 ENTREZGENE
  ENSRNOT00000087567.2 UniProtKB/TrEMBL
  ENSRNOT00000112644 ENTREZGENE
  ENSRNOT00000112644.1 UniProtKB/TrEMBL
  ENSRNOT00000115537 ENTREZGENE
  ENSRNOT00000115537.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.360 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7936834 IMAGE-MGC_LOAD
InterPro IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  Myosin_S1_N UniProtKB/TrEMBL
  Myosin_tail UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24582 UniProtKB/TrEMBL
MGC_CLONE MGC:188462 IMAGE-MGC_LOAD
NCBI Gene 24582 ENTREZGENE
Pfam Myosin_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  Myosin_tail_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myh11 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/TrEMBL
SMART MYSc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K6S9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNN9_RAT UniProtKB/TrEMBL
  A0A8I6A8G7_RAT UniProtKB/TrEMBL
  B2RYD3_RAT UniProtKB/TrEMBL
  E9PTU4 ENTREZGENE, UniProtKB/TrEMBL
  MYH11_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q58GJ0 UniProtKB/Swiss-Prot
  Q63338 UniProtKB/Swiss-Prot
  Q63339 UniProtKB/Swiss-Prot
  Q63861 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Myh11  myosin heavy chain 11  Myh11  myosin, heavy chain 11, smooth muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Myh11  myosin, heavy chain 11, smooth muscle  Myh11  myosin, heavy polypeptide 11, smooth muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-10-18 Myh11  myosin, heavy polypeptide 11, smooth muscle  RGD1564935_predicted  similar to Myh11 protein (predicted)  Data Merged 737654 APPROVED
2006-03-30 Myh11  myosin, heavy polypeptide 11, smooth muscle    myosin heavy chain 11  Name updated 1299863 APPROVED
2006-03-07 RGD1564935_predicted  similar to Myh11 protein (predicted)  LOC497849  similar to Myh11 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC497849  similar to Myh11 protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Myh11  myosin heavy chain 11    Myosin heavy chain 11  Name updated 629478 APPROVED
2002-06-10 Myh11  Myosin heavy chain 11      Symbol and Name status set to approved 70586 APPROVED