MYH11 (myosin heavy chain 11) - Rat Genome Database

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Gene: MYH11 (myosin heavy chain 11) Chlorocebus sabaeus
Analyze
Symbol: MYH11
Name: myosin heavy chain 11
RGD ID: 18454144
Description: ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); ATP binding (inferred); INVOLVED IN smooth muscle contraction (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute myeloid leukemia (ortholog); acute myelomonocytic leukemia (ortholog); FOUND IN brush border (ortholog); muscle myosin complex (ortholog); smooth muscle contractile fiber (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myosin-11
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1514,723,930 - 14,879,390 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl514,725,504 - 14,879,198 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606815,158,855 - 15,315,982 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MYH11Green Monkeyabdominal aortic aneurysm  ISOMYH11 (Homo sapiens)9068941protein:increased expression:plasmaRGDPMID:30004237 and REF_RGD_ID:13782270
MYH11Green MonkeyCOVID-19  ISOMYH11 (Homo sapiens)9068941mRNA:decreased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
MYH11Green Monkeypatent ductus arteriosus  ISOMYH11 (Homo sapiens)9068941 RGDPMID:16444274 and REF_RGD_ID:1580903
MYH11Green Monkeypatent ductus arteriosus  ISOMYH11 (Homo sapiens)9068941DNA:mutation:cds:c.4599+1delG (human)RGDPMID:27418595 and REF_RGD_ID:155883161
1 to 20 of 41 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MYH11Green Monkeyaortic aneurysm  ISOMYH11 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:22001912 more ...
MYH11Green Monkeyaortic disease  ISOMYH11 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial aortopathyClinVarPMID:24033266 more ...
MYH11Green Monkeyautistic disorder  ISOMYH11 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
MYH11Green Monkeyautosomal dominant familial visceral neuropathy  ISOMYH11 (Homo sapiens)8554872ClinVar Annotator: match by term: Pseudoobstruction idiopathic intestinalClinVarPMID:25407000
MYH11Green Monkeybicuspid aortic valve disease  ISOMYH11 (Homo sapiens)8554872ClinVar Annotator: match by term: Bicuspid aortic valveClinVarPMID:25741868 and PMID:28492532
MYH11Green Monkeyconnective tissue disease  ISOMYH11 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
MYH11Green MonkeyDesbuquois Dysplasia 1  ISOMYH11 (Homo sapiens)8554872ClinVar Annotator: match by term: Desbuquois dysplasia 1ClinVarPMID:24581741 more ...
MYH11Green MonkeyEhlers-Danlos syndrome classic type 1  ISOMYH11 (Homo sapiens)8554872ClinVar Annotator: match by term: Ehlers-Danlos syndrome and classic typeClinVarPMID:25741868 and PMID:28492532
MYH11Green Monkeyepilepsy  ISOMYH11 (Homo sapiens)8554872ClinVar Annotator: match by term: EpilepsyClinVar 
MYH11Green MonkeyFamilial Thoracic Aortic Aneurysm 1  ISOMYH11 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:22511748 more ...
MYH11Green MonkeyFamilial Thoracic Aortic Aneurysm 4  ISOMYH11 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11249915 more ...
MYH11Green MonkeyFamilial Thoracic Aortic Aneurysm 6  ISOMYH11 (Homo sapiens)8554872ClinVar Annotator: match by term: FAMILIAL THORACIC AORTIC ANEURYSM WITH LIVEDO RETICULARIS AND IRIS FLOCCULIClinVarPMID:25500235 more ...
MYH11Green MonkeyGastrointestinal Motility Disorders  ISOMYH11 (Homo sapiens)8554872ClinVar Annotator: match by term: Esophageal and colonic dysmotilityClinVarPMID:18391202
MYH11Green Monkeygenetic disease  ISOMYH11 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:17576681 more ...
MYH11Green Monkeyintestinal pseudo-obstruction  ISOMYH11 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18391202 more ...
MYH11Green Monkeyintestinal volvulus  ISOMYH11 (Homo sapiens)8554872ClinVar Annotator: match by term: INTESTINAL MALROTATION and FAMILIALClinVarPMID:25741868
MYH11Green Monkeylissencephaly  ISOMYH11 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18391202 more ...
MYH11Green Monkeylissencephaly  ISOMYH11 (Homo sapiens)8554872ClinVar Annotator: match by term: Lissencephaly and RecessiveClinVarPMID:18391202 more ...
MYH11Green Monkeylissencephaly 4  ISOMYH11 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:24033266 more ...
MYH11Green MonkeyLoeys-Dietz syndrome  ISOMYH11 (Homo sapiens)8554872ClinVar Annotator: match by term: Loeys-Dietz syndromeClinVarPMID:22511748 more ...
1 to 20 of 41 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MYH11Green Monkeyacute myeloid leukemia  ISOMYH11 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18206229 and PMID:27798625
MYH11Green Monkeyacute myelomonocytic leukemia  ISOMYH11 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:10958941
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MYH11Green MonkeyFamilial Thoracic Aortic Aneurysm 4  ISOMYH11 (Homo sapiens)7240710 OMIM 
MYH11Green MonkeyMegacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2  ISOMYH11 (Homo sapiens)7240710 OMIM 
MYH11Green MonkeyVisceral Myopathy 2  ISOMYH11 (Homo sapiens)7240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MYH11Green Monkeyactomyosin structure organization involved_inIEAPANTHER:PTN000320811150520179 TreeGrafterGO_REF:0000118
MYH11Green Monkeycardiac muscle cell development involved_inIEAUniProtKB:P35749 and ensembl:ENSP00000300036150520179 EnsemblGO_REF:0000107
MYH11Green Monkeyelastic fiber assembly involved_inIEAUniProtKB:P35749 and ensembl:ENSP00000300036150520179 EnsemblGO_REF:0000107
MYH11Green Monkeysmooth muscle contraction acts_upstream_of_or_withinISOMyh11 (Mus musculus)9068941 PMID:11715025MGIPMID:11715025
MYH11Green Monkeysmooth muscle contraction acts_upstream_of_or_withinISOMGI:35768569068941 PMID:12562924MGIPMID:12562924
MYH11Green Monkeysmooth muscle contraction acts_upstream_of_or_withinISOMGI:26564929068941 PMID:10854329MGIPMID:10854329

Cellular Component
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MYH11Green Monkeybrush border located_inISOMyh11 (Mus musculus)9068941 PMID:22114352UniProtPMID:22114352
MYH11Green Monkeycytoplasm located_inIEAPANTHER:PTN000320811150520179 TreeGrafterGO_REF:0000118
MYH11Green Monkeymuscle myosin complex part_ofISOMyh11 (Mus musculus)9068941 PMID:10854329 and PMID:11715025MGIPMID:10854329 and PMID:11715025
MYH11Green Monkeymyosin complex part_ofIEAInterPro:IPR001609 more ...150520179 InterProGO_REF:0000002
MYH11Green Monkeymyosin complex part_ofIEAUniProtKB-KW:KW-0518150520179 UniProtGO_REF:0000043
MYH11Green Monkeymyosin filament located_inIEAPANTHER:PTN000320811150520179 TreeGrafterGO_REF:0000118
MYH11Green Monkeymyosin II complex part_ofIEAARBA:ARBA00044872150520179 UniProtGO_REF:0000117
MYH11Green Monkeymyosin II complex part_ofIEAPANTHER:PTN000320811150520179 TreeGrafterGO_REF:0000118
MYH11Green Monkeysmooth muscle contractile fiber located_inISOMyh11 (Mus musculus)9068941 PMID:11715025MGIPMID:11715025
MYH11Green Monkeystress fiber located_inISOMyh11 (Mus musculus)9068941 PMID:8593698MGIPMID:8593698
MYH11Green Monkeysupramolecular fiber located_inIEAARBA:ARBA00026673150520179 UniProtGO_REF:0000117
1 to 11 of 11 rows

Molecular Function
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MYH11Green Monkeyactin binding enablesIEAUniProtKB-KW:KW-0009150520179 UniProtGO_REF:0000043
MYH11Green Monkeyactin filament binding enablesIEAInterPro:IPR008989150520179 InterProGO_REF:0000002
MYH11Green Monkeyactin filament binding enablesIEAPANTHER:PTN000320811150520179 TreeGrafterGO_REF:0000118
MYH11Green MonkeyATP binding enablesIEAInterPro:IPR001609 more ...150520179 InterProGO_REF:0000002
MYH11Green MonkeyATP binding enablesIEAUniRule:UR000686469150520179 UniProtGO_REF:0000104
MYH11Green MonkeyATP binding enablesIEAUniProtKB-KW:KW-0067150520179 UniProtGO_REF:0000043
MYH11Green Monkeycytoskeletal motor activity enablesIEAInterPro:IPR001609 more ...150520179 InterProGO_REF:0000002
MYH11Green Monkeycytoskeletal motor activity enablesIEAUniRule:UR000686469150520179 UniProtGO_REF:0000104
MYH11Green Monkeymicrofilament motor activity enablesIEAPANTHER:PTN000320811150520179 TreeGrafterGO_REF:0000118
MYH11Green Monkeynucleotide binding enablesIEAUniProtKB-KW:KW-0547150520179 UniProtGO_REF:0000043
MYH11Green Monkeyprotein binding enablesISOUniProtKB:O149509068941 PMID:19328794IntActPMID:19328794
MYH11Green Monkeystructural constituent of muscle enablesIEAUniProtKB:P35749 and ensembl:ENSP00000300036150520179 EnsemblGO_REF:0000107
1 to 12 of 12 rows

PMID:22301074  



MYH11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1514,723,930 - 14,879,390 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl514,725,504 - 14,879,198 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606815,158,855 - 15,315,982 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MYH11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381615,703,135 - 15,857,028 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1615,703,135 - 15,858,438 (-)EnsemblGRCh38hg38GRCh38
GRCh371615,796,992 - 15,950,885 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361615,704,493 - 15,858,388 (-)NCBINCBI36Build 36hg18NCBI36
Build 341615,704,494 - 15,858,369NCBI
Celera1615,477,469 - 15,631,373 (-)NCBICelera
Cytogenetic Map16p13.11NCBI
HuRef1615,190,414 - 15,344,394 (-)NCBIHuRef
CHM1_11615,881,372 - 16,035,249 (-)NCBICHM1_1
T2T-CHM13v2.01615,708,067 - 15,861,962 (-)NCBIT2T-CHM13v2.0
Myh11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391614,012,392 - 14,109,227 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1614,012,399 - 14,109,236 (-)EnsemblGRCm39 Ensembl
GRCm381614,194,527 - 14,292,188 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1614,194,535 - 14,291,372 (-)EnsemblGRCm38mm10GRCm38
MGSCv371614,194,620 - 14,291,501 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361614,108,478 - 14,204,941 (-)NCBIMGSCv36mm8
Celera1614,801,022 - 14,896,521 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.71NCBI
Myh11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8101,250,554 - 1,345,681 (+)NCBIGRCr8
mRatBN7.210743,364 - 838,459 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10743,685 - 838,459 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx105,440,444 - 5,535,220 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01035,030,622 - 35,125,399 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010754,866 - 851,396 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010764,421 - 859,184 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10764,421 - 859,184 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01011,444,263 - 11,538,406 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410666,709 - 776,540 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110767,179 - 776,535 (+)NCBI
Celera1011,333,535 - 11,428,078 (+)NCBICelera
Cytogenetic Map10q11NCBI
Myh11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955442528,880 - 644,264 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955442528,317 - 644,252 (-)NCBIChiLan1.0ChiLan1.0
MYH11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21815,760,905 - 15,915,299 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11619,543,025 - 19,698,594 (-)NCBINHGRI_mPanPan1
PanPan1.11616,006,840 - 16,091,058 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1616,007,168 - 16,091,058 (-)Ensemblpanpan1.1panPan2
MYH11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,041,330 - 28,157,277 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,041,318 - 28,262,184 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,405,013 - 29,520,689 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0628,204,726 - 28,320,508 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl628,204,776 - 28,320,502 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1628,007,790 - 28,123,460 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0627,898,014 - 28,013,477 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0628,303,247 - 28,418,936 (+)NCBIUU_Cfam_GSD_1.0
Myh11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344115,125,200 - 115,215,681 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365013,222,300 - 3,313,610 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365013,223,057 - 3,313,487 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYH11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl37,002,735 - 7,143,095 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.137,002,667 - 7,143,093 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Myh11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624782270,731 - 354,838 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624782270,183 - 373,711 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in MYH11
6304 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20



Ensembl Acc Id: ENSCSAT00000006089   ⟹   ENSCSAP00000004300
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl514,725,504 - 14,879,198 (-)Ensembl
RefSeq Acc Id: XM_007986493   ⟹   XP_007984684
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1514,724,000 - 14,879,133 (-)NCBI
Vero_WHO_p1.0NW_02366606815,158,855 - 15,315,982 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007986503   ⟹   XP_007984694
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1514,723,930 - 14,879,388 (-)NCBI
Vero_WHO_p1.0NW_02366606815,158,856 - 15,315,982 (+)NCBI
Sequence:
Protein RefSeqs XP_007984684 (Get FASTA)   NCBI Sequence Viewer  
  XP_007984694 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004300.1
RefSeq Acc Id: XP_007984694   ⟸   XM_007986503
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R6R1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007984684   ⟸   XM_007986493
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R6R1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000004300   ⟸   ENSCSAT00000006089



1 to 34 of 34 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000008043 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006089.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/TrEMBL
  1.20.5.340 UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/TrEMBL
  2.30.30.360 UniProtKB/TrEMBL
  3.30.70.1590 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  6.10.250.2420 UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/TrEMBL
  Myosin, subunit A UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  Myosin_S1_N UniProtKB/TrEMBL
  Myosin_tail UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene MYH11 ENTREZGENE
PANTHER MYOSIN HEAVY CHAIN, NON-MUSCLE UniProtKB/TrEMBL
  MYOSIN-11 UniProtKB/TrEMBL
Pfam Myosin_head UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  Myosin_tail_1 UniProtKB/TrEMBL
PRINTS MYOSINHEAVY UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/TrEMBL
SMART MYSc UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
Superfamily-SCOP Myosin rod fragments UniProtKB/TrEMBL
  Myosin S1 fragment, N-terminal domain UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9R6R1 ENTREZGENE, UniProtKB/TrEMBL
1 to 34 of 34 rows