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Akt1 |
AKT serine/threonine kinase 1 |
decreases expression multiple interactions decreases phosphorylation increases phosphorylation |
ISO EXP |
dactolisib results in decreased expression of AKT1 protein modified form dactolisib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of AKT1 protein] dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; LEPR affects the reaction [dactolisib results in decreased phosphorylation of AKT1 protein] dactolisib increases phosphorylation of Akt in rat tumor grafts |
CTD RGD |
PMID:19435893 PMID:21464613 PMID:22415236 PMID:22949526 PMID:23151917 PMID:24758408 PMID:25640480 PMID:26983879 More...
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RGD:152177690 |
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
Chloroquine promotes the reaction [dactolisib affects the folding of and results in increased activity of BAX protein]; dactolisib affects the folding of and results in increased activity of BAX protein; dactolisib promotes the reaction [Chloroquine affects the folding of and results in increased activity of BAX protein] |
CTD |
PMID:23151917 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2l1 |
Bcl2-like 1 |
affects expression |
ISO |
dactolisib affects the expression of BCL2L1 protein |
CTD |
PMID:25640480 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bcl2l11 |
Bcl2-like 11 |
affects expression |
ISO |
dactolisib affects the expression of BCL2L11 protein |
CTD |
PMID:25640480 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
dactolisib results in decreased expression of BIRC5 protein |
CTD |
PMID:22729845 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Casp3 |
caspase 3 |
increases activity increases cleavage multiple interactions |
ISO |
dactolisib results in increased activity of CASP3 protein dactolisib results in increased cleavage of CASP3 protein Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP3 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein] |
CTD |
PMID:21372221 PMID:23151917 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9 |
caspase 9 |
multiple interactions increases cleavage |
ISO |
Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP9 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP9 protein] |
CTD |
PMID:23151917 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccnd1 |
cyclin D1 |
decreases phosphorylation |
ISO |
dactolisib results in decreased phosphorylation of CCND1 protein |
CTD |
PMID:23651616 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
dactolisib results in increased expression of CDKN1A protein |
CTD |
PMID:23651616 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Ctsb |
cathepsin B |
affects localization multiple interactions |
ISO |
dactolisib affects the localization of CTSB protein [Chloroquine co-treated with dactolisib] affects the localization of CTSB protein |
CTD |
PMID:23151917 |
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NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Egf |
epidermal growth factor |
multiple interactions |
ISO |
dactolisib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:24758408 |
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NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
decreases phosphorylation increases response to substance multiple interactions |
ISO |
dactolisib results in decreased phosphorylation of EIF4EBP1 protein EIF4EBP1 protein modified form results in increased susceptibility to dactolisib Ku 0063794 inhibits the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein]; mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein] |
CTD |
PMID:21372221 PMID:22415236 PMID:23151917 PMID:25640480 |
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NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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Hsf1 |
heat shock transcription factor 1 |
decreases activity |
ISO |
dactolisib results in decreased activity of HSF1 protein |
CTD |
PMID:34170685 |
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NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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Ins1 |
insulin 1 |
multiple interactions |
ISO |
dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of OXSR1 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of SLC12A3 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of STK39 protein] |
CTD |
PMID:22949526 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Lepr |
leptin receptor |
multiple interactions |
ISO |
LEPR affects the reaction [dactolisib results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:22949526 |
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NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Map1lc3a |
microtubule-associated protein 1 light chain 3 alpha |
increases metabolic processing affects localization |
ISO |
dactolisib results in increased metabolism of MAP1LC3A protein dactolisib affects the localization of MAP1LC3A protein |
CTD |
PMID:23651616 |
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NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
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Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
dactolisib promotes the reaction [mirdametinib results in decreased phosphorylation of MAPK1 protein] |
CTD |
PMID:22415236 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
dactolisib promotes the reaction [mirdametinib results in decreased phosphorylation of MAPK3 protein] |
CTD |
PMID:22415236 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
affects expression multiple interactions |
ISO |
dactolisib affects the expression of MCL1 protein [dactolisib co-treated with (+)-JQ1 compound] affects the expression of MCL1 protein |
CTD |
PMID:25640480 |
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NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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Ogt |
O-linked N-acetylglucosamine (GlcNAc) transferase |
increases response to substance |
ISO |
OGT mutant form results in increased susceptibility to dactolisib |
CTD |
PMID:23029544 |
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NCBI chr X:66,771,278...66,816,148
Ensembl chr X:66,771,349...66,816,146
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Oxsr1 |
oxidative stress responsive kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of OXSR1 protein] dactolisib results in decreased phosphorylation of OXSR1 protein |
CTD |
PMID:22949526 |
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NCBI chr 8:118,972,754...119,062,102
Ensembl chr 8:118,972,754...119,062,027
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Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
dactolisib results in increased cleavage of PARP1 protein |
CTD |
PMID:21464613 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pik3ca |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
increases response to substance decreases response to substance |
ISO |
PIK3CA results in increased susceptibility to dactolisib PIK3CA results in decreased susceptibility to dactolisib |
CTD |
PMID:21372221 PMID:21633166 |
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NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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Pten |
phosphatase and tensin homolog |
increases response to substance |
ISO |
PTEN gene mutant form results in increased susceptibility to dactolisib |
CTD |
PMID:21372221 |
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NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Rb1 |
RB transcriptional corepressor 1 |
decreases expression |
ISO |
dactolisib results in decreased expression of RB1 protein modified form |
CTD |
PMID:23651616 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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Rps6 |
ribosomal protein S6 |
multiple interactions decreases phosphorylation |
ISO |
mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of RPS6 protein] |
CTD |
PMID:21372221 PMID:21464613 PMID:21498705 PMID:22415236 PMID:23151917 PMID:25640480 More...
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NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases phosphorylation |
ISO |
dactolisib results in decreased phosphorylation of RPS6KB1 protein |
CTD |
PMID:21464613 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Slc12a3 |
solute carrier family 12 member 3 |
multiple interactions decreases phosphorylation |
ISO |
dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of SLC12A3 protein] dactolisib results in decreased phosphorylation of SLC12A3 protein |
CTD |
PMID:22949526 |
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NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091
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Sqstm1 |
sequestosome 1 |
multiple interactions decreases expression |
ISO |
bafilomycin A1 inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein] |
CTD |
PMID:23151917 PMID:23651616 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Stk39 |
serine threonine kinase 39 |
multiple interactions decreases phosphorylation |
ISO |
dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of STK39 protein] dactolisib results in decreased phosphorylation of STK39 protein |
CTD |
PMID:22949526 |
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NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060
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