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ONTOLOGY REPORT - ANNOTATIONS


Term:dactolisib
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Accession:CHEBI:71952 term browser browse the term
Definition:An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.
Synonyms:exact_synonym: 2-methyl-2-{4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile
 related_synonym: BEZ-235;   BEZ235;   Formula=C30H23N5O;   InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3;   InChIKey=JOGKUKXHTYWRGZ-UHFFFAOYSA-N;   NVP-BEZ 235;   NVP-BEZ235;   NVPBEZ235;   SMILES=Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1
 alt_id: MESH:C531198
 xref: CAS:915019-65-7 "ChemIDplus";   LINCS:LSM-4255
 xref_mesh: MESH:C531198
 xref: PMID:22020918 "Europe PMC";   PMID:22154651 "Europe PMC";   PMID:22218692 "Europe PMC";   PMID:22287733 "Europe PMC";   PMID:22299028 "Europe PMC";   PMID:22355272 "Europe PMC";   PMID:22401294 "Europe PMC";   PMID:22415236 "Europe PMC";   PMID:22452803 "Europe PMC";   PMID:22560334 "Europe PMC";   PMID:22662154 "Europe PMC";   PMID:22727754 "Europe PMC";   PMID:22858987 "Europe PMC";   PMID:22895065 "Europe PMC";   PMID:22920938 "Europe PMC";   PMID:22960230 "Europe PMC";   PMID:22989521 "Europe PMC";   PMID:23077520 "Europe PMC";   PMID:23215722 "Europe PMC";   PMID:23232026 "Europe PMC";   PMID:23300274 "Europe PMC";   PMID:23319394 "Europe PMC";   PMID:23319457 "Europe PMC";   PMID:23321494 "Europe PMC";   PMID:23343422 "Europe PMC";   Patent:WO2006122806;   Patent:WO2008064093;   Reaxys:12748665 "Reaxys"


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dactolisib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:6480464
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6480464
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase JBrowse link X 71,540,870 71,585,906 RGD:6480464
G Oxsr1 oxidative stress responsive kinase 1 JBrowse link 8 127,920,349 128,009,951 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6480464
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Slc12a3 solute carrier family 12 member 3 JBrowse link 19 11,106,033 11,144,674 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6480464
G Stk39 serine threonine kinase 39 JBrowse link 3 54,359,449 54,625,702 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19614
    chemical entity 19612
      group 19527
        pseudohalo group 2769
          cyano group 2769
            nitrile 2769
              dactolisib 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19614
    subatomic particle 19610
      composite particle 19610
        hadron 19610
          baryon 19610
            nucleon 19610
              atomic nucleus 19610
                atom 19610
                  main group element atom 19489
                    p-block element atom 19489
                      carbon group element atom 19362
                        carbon atom 19354
                          organic molecular entity 19354
                            organic group 18313
                              organic divalent group 18303
                                organodiyl group 18303
                                  carbonyl group 18188
                                    carbonyl compound 18188
                                      carboxylic acid 17853
                                        carboacyl group 16940
                                          univalent carboacyl group 16940
                                            carbamoyl group 16620
                                              carboxamide 16620
                                                monocarboxylic acid amide 13184
                                                  urea 4931
                                                    ureas 4928
                                                      dactolisib 25
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.