Oxsr1 (oxidative stress responsive kinase 1) - Rat Genome Database

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Gene: Oxsr1 (oxidative stress responsive kinase 1) Rattus norvegicus
Analyze
Symbol: Oxsr1
Name: oxidative stress responsive kinase 1
RGD ID: 1310466
Description: Predicted to enable several functions, including ATP binding activity; identical protein binding activity; and magnesium ion binding activity. Predicted to be involved in several processes, including cellular response to osmotic stress; chemokine-mediated signaling pathway; and protein phosphorylation. Predicted to be located in cytosol. Orthologous to human OXSR1 (oxidative stress responsive kinase 1); INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC316064; Osr1; oxidative-stress responsive 1; serine/threonine-protein kinase OSR1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28118,972,754 - 119,062,102 (-)NCBI
Rnor_6.0 Ensembl8127,920,349 - 128,009,951 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08127,920,349 - 128,009,951 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08127,127,110 - 127,216,712 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,196,599 - 124,286,647 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,217,575 - 124,306,410 (-)NCBI
Celera8118,123,990 - 118,213,225 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:12386165   PMID:14707132   PMID:16669787   PMID:16832045   PMID:19056867   PMID:22052202   PMID:24393035   PMID:25515571   PMID:27400149   PMID:31362998   PMID:31954517  


Genomics

Comparative Map Data
Oxsr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28118,972,754 - 119,062,102 (-)NCBI
Rnor_6.0 Ensembl8127,920,349 - 128,009,951 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08127,920,349 - 128,009,951 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08127,127,110 - 127,216,712 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,196,599 - 124,286,647 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,217,575 - 124,306,410 (-)NCBI
Celera8118,123,990 - 118,213,225 (-)NCBICelera
Cytogenetic Map8q32NCBI
OXSR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl338,165,089 - 38,255,484 (+)EnsemblGRCh38hg38GRCh38
GRCh38338,165,051 - 38,255,486 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37338,207,028 - 38,296,975 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,182,030 - 38,271,983 (+)NCBINCBI36hg18NCBI36
Build 34338,182,029 - 38,271,979NCBI
Celera338,142,644 - 38,232,606 (+)NCBI
Cytogenetic Map3p22.2NCBI
HuRef338,248,039 - 38,338,925 (+)NCBIHuRef
CHM1_1338,158,703 - 38,248,663 (+)NCBICHM1_1
Oxsr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,067,498 - 119,154,475 (-)NCBIGRCm39mm39
GRCm39 Ensembl9119,067,498 - 119,151,493 (-)Ensembl
GRCm389119,238,432 - 119,322,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,238,432 - 119,322,427 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,149,784 - 119,213,966 (-)NCBIGRCm37mm9NCBIm37
MGSCv369119,087,131 - 119,171,125 (-)NCBImm8
Celera9119,708,063 - 119,774,018 (-)NCBICelera
Cytogenetic Map9F3NCBI
Oxsr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542725,575,655 - 25,696,356 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542725,575,655 - 25,696,356 (+)NCBIChiLan1.0ChiLan1.0
OXSR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1338,345,491 - 38,436,279 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,345,504 - 38,436,275 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0338,063,299 - 38,153,609 (+)NCBIMhudiblu_PPA_v0panPan3
OXSR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,931,636 - 8,026,591 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,932,254 - 8,024,323 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha237,973,576 - 8,067,716 (+)NCBI
ROS_Cfam_1.0238,221,226 - 8,313,574 (+)NCBI
UMICH_Zoey_3.1238,035,117 - 8,130,106 (+)NCBI
UNSW_CanFamBas_1.0238,175,999 - 8,270,428 (+)NCBI
UU_Cfam_GSD_1.0238,168,533 - 8,263,795 (+)NCBI
Oxsr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,421,183 - 194,519,453 (-)NCBI
SpeTri2.0NW_00493647327,559,756 - 27,658,299 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OXSR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,020,530 - 23,116,958 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,020,839 - 23,116,957 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,225,156 - 25,288,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OXSR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,164,529 - 1,255,935 (-)NCBI
ChlSab1.1 Ensembl151,164,528 - 1,255,925 (-)Ensembl
Vero_WHO_p1.0NW_0236660639,895,779 - 9,985,796 (-)NCBI
Oxsr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247312,703,295 - 2,825,017 (+)NCBI

Position Markers
D8Got351  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,056,955 - 119,057,094 (+)MAPPER
Rnor_6.08128,004,880 - 128,005,018NCBIRnor6.0
Rnor_5.08127,211,641 - 127,211,779UniSTSRnor5.0
RGSC_v3.48124,281,577 - 124,281,715UniSTSRGSC3.4
Celera8118,208,155 - 118,208,293UniSTS
Cytogenetic Map8q32UniSTS
RH130404  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28118,972,931 - 118,973,114 (+)MAPPER
Rnor_6.08127,920,527 - 127,920,709NCBIRnor6.0
Rnor_5.08127,127,288 - 127,127,470UniSTSRnor5.0
RGSC_v3.48124,196,777 - 124,196,959UniSTSRGSC3.4
Celera8118,124,168 - 118,124,350UniSTS
RH 3.4 Map81302.4UniSTS
Cytogenetic Map8q32UniSTS
RH132547  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,062,968 - 119,063,160 (+)MAPPER
Rnor_6.08128,010,892 - 128,011,083NCBIRnor6.0
Rnor_5.08127,217,653 - 127,217,844UniSTSRnor5.0
RGSC_v3.48124,287,588 - 124,287,779UniSTSRGSC3.4
Celera8118,214,166 - 118,214,357UniSTS
RH 3.4 Map81288.5UniSTS
Cytogenetic Map8q32UniSTS
RH143190  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,037,457 - 119,037,569 (+)MAPPER
Rnor_6.08127,985,006 - 127,985,117NCBIRnor6.0
Rnor_5.08127,191,767 - 127,191,878UniSTSRnor5.0
RGSC_v3.48124,262,083 - 124,262,194UniSTSRGSC3.4
Celera8118,188,661 - 118,188,772UniSTS
RH 3.4 Map81312.6UniSTS
Cytogenetic Map8q32UniSTS
RH139291  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,037,318 - 119,037,445 (+)MAPPER
Rnor_6.08127,984,867 - 127,984,993NCBIRnor6.0
Rnor_5.08127,191,628 - 127,191,754UniSTSRnor5.0
RGSC_v3.48124,261,944 - 124,262,070UniSTSRGSC3.4
Celera8118,188,522 - 118,188,648UniSTS
Cytogenetic Map8q32UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)850529480128036471Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)865717449128033050Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)883894304128894304Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)889058229132243842Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8100873811133307652Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102051964133307652Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8104682575133307652Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)8104682575133307652Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8107769005129956433Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:363
Count of miRNA genes:217
Interacting mature miRNAs:265
Transcripts:ENSRNOT00000018056
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 47 31 19 31 8 11 74 35 37 11 8
Low 10 10 10 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018056   ⟹   ENSRNOP00000018056
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8127,920,349 - 128,009,951 (-)Ensembl
RefSeq Acc Id: NM_001108194   ⟹   NP_001101664
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28118,972,754 - 119,062,027 (-)NCBI
Rnor_6.08127,920,349 - 128,009,951 (-)NCBI
Rnor_5.08127,127,110 - 127,216,712 (-)NCBI
RGSC_v3.48124,196,599 - 124,286,647 (-)RGD
Celera8118,123,990 - 118,213,225 (-)RGD
Sequence:
RefSeq Acc Id: XR_005487857
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28118,996,812 - 119,062,102 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101664 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL76918 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101664   ⟸   NM_001108194
- UniProtKB: D3ZUC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018056   ⟸   ENSRNOT00000018056
Protein Domains
Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696368
Promoter ID:EPDNEW_R6893
Type:initiation region
Name:Oxsr1_1
Description:oxidative-stress responsive 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08128,009,916 - 128,009,976EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310466 AgrOrtholog
Ensembl Genes ENSRNOG00000013136 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018056 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018056 ENTREZGENE, UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/TrEMBL
  Oxsr1 UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
KEGG Report rno:316064 UniProtKB/TrEMBL
NCBI Gene 316064 ENTREZGENE
PANTHER PTHR48012:SF1 UniProtKB/TrEMBL
Pfam OSR1_C UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Oxsr1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt D3ZUC9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-01 Oxsr1  oxidative stress responsive kinase 1  Oxsr1  oxidative-stress responsive 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Oxsr1  oxidative-stress responsive 1   Oxsr1_predicted  oxidative-stress responsive 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Oxsr1_predicted  oxidative-stress responsive 1 (predicted)      Symbol and Name updated 1299863 APPROVED
2006-03-28 Oxsr1_predicted    Osr1_predicted  oxidative-stress responsive 1 (predicted)  Symbol updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-12 Osr1_predicted  oxidative-stress responsive 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED