Slc22a13 (solute carrier family 22 member 13) - Rat Genome Database

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Gene: Slc22a13 (solute carrier family 22 member 13) Rattus norvegicus
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Symbol: Slc22a13
Name: solute carrier family 22 member 13
RGD ID: 1306840
Description: Predicted to enable nicotinate transmembrane transporter activity and urate transmembrane transporter activity. Predicted to be involved in negative regulation of fatty acid metabolic process; organic anion transport; and positive regulation of T cell mediated cytotoxicity directed against tumor cell target. Predicted to be located in Golgi apparatus; apical plasma membrane; and endoplasmic reticulum. Orthologous to human SLC22A13 (solute carrier family 22 member 13); PARTICIPATES IN nicotinamide adenine dinucleotide metabolic pathway; INTERACTS WITH bisphenol A; cyclosporin A; methamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC316062; OAT10; ORCTL-3; organic anion transporter 10; organic cation transporter-like 3; solute carrier family 22 (organic anion transporter), member 13; solute carrier family 22 (organic anion/urate transporter), member 13; solute carrier family 22 (organic cation transporter), member 13
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,800,097 - 127,811,750 (-)NCBIGRCr8
mRatBN7.28118,922,367 - 118,934,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,922,367 - 118,953,635 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,523,764 - 124,535,564 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,722,731 - 122,734,583 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,555,873 - 120,567,444 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,885,268 - 127,900,829 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,885,268 - 127,900,463 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,092,455 - 127,107,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,159,275 - 124,174,462 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,179,329 - 124,209,653 (-)NCBI
Celera8118,095,450 - 118,105,170 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. The human NAD metabolome: Functions, metabolism and compartmentalization. Nikiforov A, etal., Crit Rev Biochem Mol Biol. 2015;50(4):284-97. doi: 10.3109/10409238.2015.1028612. Epub 2015 Apr 2.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10072596   PMID:12477932   PMID:18411268   PMID:19056867   PMID:19282870   PMID:23376485   PMID:24147638   PMID:24769897  


Genomics

Comparative Map Data
Slc22a13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,800,097 - 127,811,750 (-)NCBIGRCr8
mRatBN7.28118,922,367 - 118,934,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,922,367 - 118,953,635 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,523,764 - 124,535,564 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,722,731 - 122,734,583 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,555,873 - 120,567,444 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,885,268 - 127,900,829 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,885,268 - 127,900,463 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,092,455 - 127,107,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,159,275 - 124,174,462 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,179,329 - 124,209,653 (-)NCBI
Celera8118,095,450 - 118,105,170 (-)NCBICelera
Cytogenetic Map8q32NCBI
SLC22A13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,265,812 - 38,278,757 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,265,812 - 38,278,757 (+)EnsemblGRCh38hg38GRCh38
GRCh37338,307,303 - 38,320,248 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,282,335 - 38,294,810 (+)NCBINCBI36Build 36hg18NCBI36
Build 34338,282,334 - 38,294,810NCBI
Celera338,242,927 - 38,255,435 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef338,349,252 - 38,361,760 (+)NCBIHuRef
CHM1_1338,258,992 - 38,271,500 (+)NCBICHM1_1
T2T-CHM13v2.0338,271,525 - 38,284,466 (+)NCBIT2T-CHM13v2.0
Slc22a13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,020,618 - 119,038,171 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,022,040 - 119,038,164 (-)EnsemblGRCm39 Ensembl
GRCm389119,192,966 - 119,209,105 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,192,974 - 119,209,098 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,102,092 - 119,118,223 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,041,672 - 119,057,784 (-)NCBIMGSCv36mm8
Celera9119,660,862 - 119,676,484 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI

Variants

.
Variants in Slc22a13
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:115
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000045105
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat

Markers in Region
RH141526  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28118,922,448 - 118,922,642 (+)MAPPERmRatBN7.2
Rnor_6.08127,885,350 - 127,885,543NCBIRnor6.0
Rnor_5.08127,092,632 - 127,092,825UniSTSRnor5.0
RGSC_v3.48124,159,357 - 124,159,550UniSTSRGSC3.4
Celera8118,095,532 - 118,095,725UniSTS
RH 3.4 Map81289.2UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 19
Low 4 1 3 1 21 10 7 1
Below cutoff 3 41 46 33 15 33 7 9 53 6 32 9 7

Sequence


RefSeq Acc Id: ENSRNOT00000078303   ⟹   ENSRNOP00000075628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8118,922,367 - 118,953,609 (-)Ensembl
Rnor_6.0 Ensembl8127,885,268 - 127,900,463 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094542   ⟹   ENSRNOP00000085528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8118,942,695 - 118,953,635 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099503   ⟹   ENSRNOP00000076627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8118,922,367 - 118,933,994 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104015   ⟹   ENSRNOP00000088097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8118,922,685 - 118,933,994 (-)Ensembl
RefSeq Acc Id: NM_001126285   ⟹   NP_001119757
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,800,097 - 127,811,750 (-)NCBI
mRatBN7.28118,922,367 - 118,934,020 (-)NCBI
Rnor_6.08127,885,268 - 127,900,463 (-)NCBI
Rnor_5.08127,092,455 - 127,107,283 (-)NCBI
RGSC_v3.48124,159,275 - 124,174,462 (-)RGD
Celera8118,095,450 - 118,105,170 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001119757 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66511 (Get FASTA)   NCBI Sequence Viewer  
  B2GV36 (Get FASTA)   NCBI Sequence Viewer  
  EDL76920 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075628.1
  ENSRNOP00000076627
  ENSRNOP00000076627.1
  ENSRNOP00000088097.1
  ENSRNOP00065004667
RefSeq Acc Id: NP_001119757   ⟸   NM_001126285
- UniProtKB: B2GV36 (UniProtKB/TrEMBL),   A0A8I6A5H4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075628   ⟸   ENSRNOT00000078303
RefSeq Acc Id: ENSRNOP00000076627   ⟸   ENSRNOT00000099503
RefSeq Acc Id: ENSRNOP00000088097   ⟸   ENSRNOT00000104015
RefSeq Acc Id: ENSRNOP00000085528   ⟸   ENSRNOT00000094542
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GV36-F1-model_v2 AlphaFold B2GV36 1-551 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306840 AgrOrtholog
BioCyc Gene G2FUF-28798 BioCyc
Ensembl Genes ENSRNOG00000056476 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065004676 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000078303.2 UniProtKB/Swiss-Prot
  ENSRNOT00000099503 ENTREZGENE
  ENSRNOT00000099503.1 UniProtKB/Swiss-Prot
  ENSRNOT00000104015.1 UniProtKB/TrEMBL
  ENSRNOT00065006783 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128568 IMAGE-MGC_LOAD
InterPro Major_facilitator_SF UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sub_transporter UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:316062 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188079 IMAGE-MGC_LOAD
NCBI Gene 316062 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 22 MEMBER 13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc22a13 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056476 RatGTEx
  ENSRNOG00065004676 RatGTEx
Superfamily-SCOP MFS_gen_substrate_transporter UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A0A8I6A5H4 ENTREZGENE, UniProtKB/TrEMBL
  B2GV36 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc22a13  solute carrier family 22 member 13  Slc22a13  solute carrier family 22 (organic anion/urate transporter), member 13  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc22a13  solute carrier family 22 (organic anion/urate transporter), member 13  Slc22a13  solute carrier family 22 (organic anion transporter), member 13  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc22a13  solute carrier family 22 (organic anion transporter), member 13  Slc22a13  solute carrier family 22 (organic cation transporter), member 13   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Slc22a13  solute carrier family 22 (organic cation transporter), member 13   Slc22a13_predicted  solute carrier family 22 (organic cation transporter), member 13 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slc22a13_predicted  solute carrier family 22 (organic cation transporter), member 13 (predicted)      Symbol and Name status set to approved 70820 APPROVED