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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1565692
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Suv39h1-ps1
Name: SUV39H1 histone lysine methyltransferase, pseudogene 1
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Suv39h1-ps1multiple interactionsISOSUV39H1 (Homo sapiens)6480464CTD[TNF protein co-treated with Sirolimus co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased ubiquitination of SUV39H1 protein; [TNF protein co-treated with Sirolimus] results in decreased expression of SUV39H1 proteinPMID:31676321
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