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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDSirolimus inhibits the reaction [cadmium acetate results in increased expression of CASP12 protein]

PMID:29870746
decreases cleavageISORGD:7314426480464CTDSirolimus results in decreased cleavage of CASP12 protein

PMID:20511674
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.