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Accession:CHEBI:85572 term browser browse the term
Definition:A member of the class of pyridopyrimidines that is an mTOR inhibitor and shows anti-tumour properties.
Synonyms:exact_synonym: (5-{2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-(morpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl}-2-methoxyphenyl)methanol
 related_synonym: Formula=C25H31N5O4;   InChI=1S/C25H31N5O4/c1-16-13-30(14-17(2)34-16)25-27-23-20(24(28-25)29-8-10-33-11-9-29)5-6-21(26-23)18-4-7-22(32-3)19(12-18)15-31/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17+;   InChIKey=RFSMUFRPPYDYRD-CALCHBBNSA-N;   KU-63794;   KU0063794;   SMILES=COc1ccc(cc1CO)-c1ccc2c(nc(nc2n1)N1C[C@H](C)O[C@H](C)C1)N1CCOCC1
 xref: CAS:938440-64-3 "ChemIDplus";   LINCS:LSM-5754
 xref_mesh: MESH:C541932
 xref: PMID:19402821 "Europe PMC";   PMID:23349989 "Europe PMC";   PMID:25618298 "Europe PMC";   PMID:25651869 "Europe PMC";   Reaxys:12909210 "Reaxys"

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Ku-0063794 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:6480464
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      application 19232
        pharmaceutical 19094
          drug 19094
            antineoplastic agent 16568
              Ku-0063794 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic molecule 19337
                              organic cyclic compound 19089
                                carbocyclic compound 17514
                                  benzenoid aromatic compound 17036
                                    benzenes 16751
                                      methoxybenzenes 806
                                        monomethoxybenzene 718
                                          Ku-0063794 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.