hydroxyanthraquinones - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	hydroxyanthraquinones	go back to main search page
Accession:	CHEBI:37485	browse the term
Definition:	An anthraquinone substituted with one or more hydroxy groups.
Synonyms:	alt_id:	CHEBI:13829; CHEBI:24672

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Rat (514) Mouse (519) Human (534) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (514)

1-hydroxyanthraquinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

1-hydroxyanthraquinone results in decreased activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

2-hydroxychrysophanol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases chemical synthesis
multiple interactions

CYP1A2 protein results in increased chemical synthesis of 2-hydroxychrysophanol
[CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases chemical synthesis

[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol
CYP3A4 protein results in increased chemical synthesis of 2-hydroxychrysophanol

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

affects binding

Alizarin Red S binds to ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

alizarin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity
multiple interactions

alizarin results in decreased activity of CYP1A1 protein
alizarin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein]

PMID:12379470 PMID:37515497

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

alizarin results in decreased activity of CYP1A2 protein

PMID:12379470 PMID:33438235

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

alizarin results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

alizarin results in decreased activity of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023

G

estrogen receptor 1

multiple interactions

alizarin binds to and results in increased activity of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002

G

H2A.X variant histone

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

mitogen activated protein kinase 1

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; alizarin inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein]

PMID:33421718 PMID:38670245

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]; alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC protein]

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:196,864,336...196,896,475

G

N-acetyltransferase 1

decreases activity

alizarin results in decreased activity of NAT1 protein

NCBI chr16:26,984,882...27,005,194
Ensembl chr16:22,208,194...22,238,520

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of alizarin

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of alizarin

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of alizarin

NCBI chr14:21,122,866...21,138,450
Ensembl chr14:20,768,015...20,783,589

Aloe emodin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in decreased expression of ADIPOQ mRNA]

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564

G

aldo-keto reductase family 1 member B10

decreases activity

aloe emodin results in decreased activity of AKR1B10 protein

NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C3

decreases activity

aloe emodin results in decreased activity of AKR1C3 protein

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873

G

activating transcription factor 3

increases expression

aloe emodin results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631

G

BCL2 associated X, apoptosis regulator

increases expression

aloe emodin results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

aloe emodin results in decreased expression of BCL2 mRNA; aloe emodin results in decreased expression of BCL2 protein

PMID:19928967 PMID:22210228

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

increases activity
multiple interactions
increases cleavage
increases expression

aloe emodin results in increased activity of CASP3 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP3; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP3 protein modified form]
aloe emodin results in increased cleavage of CASP3 protein

PMID:19928967 PMID:22210228

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity
multiple interactions
increases expression

aloe emodin results in increased activity of CASP8 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP8; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP8 protein modified form]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity
increases expression
multiple interactions

aloe emodin results in increased activity of CASP9 protein
aloe emodin results in increased expression of CASP9 protein modified form
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP9; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP9 protein modified form]

Ensembl chr 5:154,109,046...154,126,626

G

carbonyl reductase 1

decreases activity

aloe emodin results in decreased activity of CBR1 protein

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

cytochrome c, somatic

increases expression

aloe emodin results in increased expression of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

aloe emodin results in decreased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

aloe emodin results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:33438235

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

aloe emodin results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases chemical synthesis

[CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CYP2B6 protein results in increased chemical synthesis of aloe emodin

NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

aloe emodin results in decreased activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases chemical synthesis
multiple interactions

CYP3A4 protein results in increased chemical synthesis of aloe emodin
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

DNA-damage inducible transcript 3

increases expression

aloe emodin results in increased expression of DDIT3 mRNA; aloe emodin results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

aloe emodin results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225

G

fatty acid binding protein 4

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of FABP4 mRNA]

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578

G

Fas associated via death domain

multiple interactions

aloe emodin results in increased expression of and affects the localization of FADD protein

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:199,739,994...199,745,653

G

Fas cell surface death receptor

increases expression

aloe emodin results in increased expression of FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

aloe emodin results in increased expression of FASLG protein

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215

G

heat shock protein family A (Hsp70) member 5

increases expression

aloe emodin results in increased expression of HSPA5 mRNA; aloe emodin results in increased expression of HSPA5 protein

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891

G

lipoprotein lipase

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of LPL mRNA]

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249

G

N-acetyltransferase 1

multiple interactions
decreases expression

aloe emodin results in decreased expression of and results in decreased activity of NAT1 protein
aloe emodin results in decreased expression of NAT1 mRNA

NCBI chr16:26,984,882...27,005,194
Ensembl chr16:22,208,194...22,238,520

G

nitric oxide synthase 2

multiple interactions

aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

peroxisome proliferator-activated receptor gamma

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of PPARG mRNA]

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

multiple interactions

aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

resistin

multiple interactions

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of RETN mRNA]

NCBI chr12:6,508,653...6,511,115
Ensembl chr12:1,710,881...1,712,620

G

sulfotransferase family 1A member 1

decreases activity

aloe emodin results in decreased activity of SULT1A1 protein

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 1E member 1

decreases activity

aloe emodin results in decreased activity of SULT1E1 protein

NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,422,324...20,439,275

G

tumor necrosis factor

multiple interactions
increases expression

aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of TNF mRNA]
aloe emodin results in increased expression of TNF protein

PMID:19928967 PMID:22645054

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

increases expression

aloe emodin results in increased expression of TNFRSF1A protein

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

increases expression

aloe emodin results in increased expression of TNFRSF1B protein

NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206

G

tumor protein p53

increases expression

aloe emodin results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

TNFRSF1A-associated via death domain

multiple interactions

aloe emodin results in increased expression of and affects the localization of TRADD protein

NCBI chr19:50,046,057...50,048,158
Ensembl chr19:33,136,138...33,142,638

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of aloe emodin

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465

G

X-box binding protein 1

increases splicing

aloe emodin results in increased splicing of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693

anthraflavic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

2,6-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

albumin

affects binding

2,6-dihydroxyanthraquinone binds to ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

2,6-dihydroxyanthraquinone results in increased expression of CYP1A1 mRNA

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

2,6-dihydroxyanthraquinone results in increased expression of CYP1B1 mRNA

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

PMID:12756209 PMID:14557274

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465

aurantio-obtusin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

aurantio-obtusin inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

acyl-CoA synthetase long-chain family member 4

increases expression

aurantio-obtusin results in increased expression of ACSL4 protein

NCBI chr X:110,739,633...110,803,416
Ensembl chr X:105,942,799...106,006,427

G

BCL2 associated X, apoptosis regulator

increases expression

aurantio-obtusin results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

aurantio-obtusin results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 1

increases expression

aurantio-obtusin results in increased expression of CASP1 mRNA

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

increases cleavage
multiple interactions

aurantio-obtusin results in increased cleavage of CASP3 protein
aurantio-obtusin results in increased expression of and results in increased cleavage of CASP3 protein

PMID:34718095 PMID:35995123

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

C-C motif chemokine ligand 2

increases expression

aurantio-obtusin results in increased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

CREB binding protein

increases phosphorylation

aurantio-obtusin results in increased phosphorylation of CREBBP protein

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,335,953...11,461,888

G

glutamic--pyruvic transaminase

increases expression

aurantio-obtusin results in increased expression of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494

G

hepcidin antimicrobial peptide

decreases expression

aurantio-obtusin results in decreased expression of HAMP mRNA

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891

G

interleukin 18

increases expression

aurantio-obtusin results in increased expression of IL18 mRNA; aurantio-obtusin results in increased expression of IL18 protein

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

increases expression

aurantio-obtusin results in increased expression of IL1B mRNA; aurantio-obtusin results in increased expression of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression
multiple interactions

aurantio-obtusin results in increased expression of IL6 mRNA
aurantio-obtusin inhibits the reaction [Bleomycin results in increased secretion of IL6 protein]

PMID:28299617 PMID:34718095

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

potassium calcium-activated channel subfamily N member 4

increases expression

aurantio-obtusin results in increased expression of KCNN4 mRNA; aurantio-obtusin results in increased expression of KCNN4 protein

NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:79,959,322...79,974,340

G

nuclear factor kappa B subunit 1

decreases expression

aurantio-obtusin results in decreased expression of NFKB1 mRNA

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

NLR family, pyrin domain containing 3

increases expression

aurantio-obtusin results in increased expression of NLRP3 mRNA; aurantio-obtusin results in increased expression of NLRP3 protein

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811

G

RELA proto-oncogene, NF-kB subunit

decreases expression

aurantio-obtusin results in decreased expression of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 22 member 6

decreases activity

aurantio-obtusin results in decreased activity of SLC22A6 protein

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

decreases activity

aurantio-obtusin results in decreased activity of SLC22A8 protein

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450

G

sialophorin

increases expression

aurantio-obtusin results in increased expression of SPN mRNA

NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:181,746,429...181,759,628

G

tumor necrosis factor

increases expression

aurantio-obtusin results in increased expression of TNF mRNA

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

exportin 1

decreases expression

aurantio-obtusin results in decreased expression of XPO1 mRNA

NCBI chr14:101,434,450...101,476,705
Ensembl chr14:97,233,270...97,275,498

Capoamycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

increases activity

capoamycin results in increased activity of AHR protein

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

chrysazin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

danthron inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions
increases expression

danthron affects the localization of and results in increased expression of AIFM1 protein
danthron results in increased expression of AIFM1 mRNA

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:127,650,226...127,689,256

G

albumin

affects binding

danthron binds to ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

activating transcription factor 6

increases expression

danthron results in increased expression of ATF6 protein

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177

G

BCL2 associated X, apoptosis regulator

increases expression

danthron results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

danthron results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression
decreases expression

danthron results in increased expression of BCL2L1 protein
danthron results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

BH3 interacting domain death agonist

increases expression

danthron results in increased expression of BID protein

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 2

decreases expression

danthron results in decreased expression of BIRC2 protein

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

increases expression

danthron results in increased expression of BIRC3 protein

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

decreases expression

danthron results in decreased expression of BIRC5 protein

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

caspase 3

multiple interactions
increases expression

benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP3 protein]; danthron results in increased activity of and results in increased expression of CASP3 protein
danthron results in increased expression of CASP3 mRNA

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions
increases expression

benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP8 protein]; danthron results in increased activity of and results in increased expression of CASP8 protein
danthron results in increased expression of CASP8 mRNA

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases expression

benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP9 protein]; danthron results in increased activity of and results in increased expression of CASP9 protein
danthron results in increased expression of CASP9 mRNA

Ensembl chr 5:154,109,046...154,126,626

G

cytochrome c, somatic

multiple interactions

danthron affects the localization of and results in increased expression of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

danthron results in decreased activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

DNA-damage inducible transcript 3

increases expression

danthron results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

diablo, IAP-binding mitochondrial protein

increases expression

danthron results in increased expression of DIABLO protein

NCBI chr12:38,716,668...38,731,285
Ensembl chr12:33,055,263...33,070,387

G

endonuclease G

increases expression
multiple interactions

danthron results in increased expression of ENDOG mRNA
danthron affects the localization of and results in increased expression of ENDOG protein

NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:13,449,086...13,451,932

G

Fas cell surface death receptor

increases expression

danthron results in increased expression of FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

danthron results in increased expression of FASLG protein

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215

G

heat shock protein family A (Hsp70) member 5

increases expression

danthron results in increased expression of HSPA5 protein

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891

G

superoxide dismutase 1

decreases expression

danthron results in decreased expression of SOD1 protein

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression

danthron results in decreased expression of SOD2 protein

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

TNF superfamily member 10

increases expression

danthron results in increased expression of TNFSF10 protein

NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135

G

X-linked inhibitor of apoptosis

decreases expression

danthron results in decreased expression of XIAP protein

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700

chrysophanol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases expression

chrysophanic acid results in decreased expression of ABCB11 mRNA; chrysophanic acid results in decreased expression of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily C member 2

increases expression

chrysophanic acid results in increased expression of ABCC2 mRNA; chrysophanic acid results in increased expression of ABCC2 protein

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 4

increases expression

chrysophanic acid results in increased expression of ABCC4 mRNA; chrysophanic acid results in increased expression of ABCC4 protein

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283

G

aryl hydrocarbon receptor

multiple interactions

chrysophanic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

AKT serine/threonine kinase 1

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

BCL2-antagonist/killer 1

increases expression

chrysophanic acid results in increased expression of BAK1 protein

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

increases expression

chrysophanic acid results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

chrysophanic acid results in decreased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
multiple interactions
increases metabolic processing

chrysophanic acid results in decreased activity of CYP1A2 protein
[CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol

PMID:27633141 PMID:29698620 PMID:33438235

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

chrysophanic acid results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases metabolic processing

[CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin

NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing
increases chemical synthesis
multiple interactions

CYP3A4 protein results in increased metabolism of chrysophanic acid
CYP3A4 protein results in increased chemical synthesis of chrysophanic acid metabolite
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol; [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450 family 7 subfamily A member 1

increases expression

chrysophanic acid results in increased expression of CYP7A1 mRNA; chrysophanic acid results in increased expression of CYP7A1 protein

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

chrysophanic acid results in decreased expression of CYP8B1 mRNA; chrysophanic acid results in decreased expression of CYP8B1 protein

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:121,557,062...121,580,166

G

DNA-damage inducible transcript 3

increases expression

chrysophanic acid results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation
multiple interactions

chrysophanic acid results in increased phosphorylation of EIF2AK3 protein
Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation
multiple interactions

chrysophanic acid results in increased phosphorylation of EIF2S1 protein
Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2S1 protein]

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225

G

endoplasmic reticulum to nucleus signaling 1

increases expression

chrysophanic acid results in increased expression of ERN1 protein

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029

G

mitogen activated protein kinase 1

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

affects phosphorylation

chrysophanic acid affects the phosphorylation of MAPK14 protein

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

affects phosphorylation

chrysophanic acid affects the phosphorylation of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

proliferating cell nuclear antigen

decreases expression

chrysophanic acid results in decreased expression of PCNA protein

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

ribosomal protein S6

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of RPS6 protein

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase B1

decreases phosphorylation

chrysophanic acid results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908

G

solute carrier family 10 member 1

decreases expression

chrysophanic acid results in decreased expression of SLC10A1 mRNA; chrysophanic acid results in decreased expression of SLC10A1 protein

NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 22 member 6

decreases activity

chrysophanic acid results in decreased activity of SLC22A6 protein

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

decreases activity

chrysophanic acid results in decreased activity of SLC22A8 protein

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450

G

sulfotransferase family 1A member 1

decreases activity

chrysophanic acid results in decreased activity of SULT1A1 protein

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:181,272,023...181,275,562

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of chrysophanic acid

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465

Citreorosein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases chemical synthesis

CYP2C19 protein results in increased chemical synthesis of 1,3,8-trihydroxy-6-hydroxymethylanthraquinone

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases chemical synthesis

CYP3A4 protein results in increased chemical synthesis of 1,3,8-trihydroxy-6-hydroxymethylanthraquinone

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

emodin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

increases expression
multiple interactions
affects activity
decreases expression

Emodin results in increased expression of ABCB11 mRNA; Emodin results in increased expression of ABCB11 protein
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside affects the reaction [[Emodin affects the activity of ABCB11 protein] which affects the export of Taurocholic Acid]; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCB11 protein; [Emodin affects the activity of ABCB11 protein] which affects the export of Taurocholic Acid
dorsomorphin inhibits the reaction [Emodin results in decreased expression of ABCB11 mRNA]; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA]
Emodin results in decreased expression of ABCB11 mRNA; Emodin results in decreased expression of ABCB11 protein

PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

multiple interactions
increases expression

Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
Emodin results in increased expression of ABCB1A mRNA
ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]

PMID:19549930 PMID:24380838

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

increases expression

Emodin results in increased expression of ABCB1B mRNA

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily B member 4

decreases expression

Emodin results in decreased expression of ABCB4 mRNA

NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 2

increases expression
multiple interactions
decreases expression

Emodin results in increased expression of ABCC2 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of ABCC2 protein; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC2 protein
Emodin results in decreased expression of ABCC2 mRNA
Emodin results in decreased expression of ABCC2 mRNA; Emodin results in decreased expression of ABCC2 protein

PMID:19549930 PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression
multiple interactions
decreases expression

Emodin results in increased expression of ABCC3 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of ABCC3 protein; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC3 protein
Emodin results in decreased expression of ABCC3 mRNA
Emodin results in decreased expression of ABCC3 mRNA; Emodin results in decreased expression of ABCC3 protein

PMID:19549930 PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

decreases expression
multiple interactions

Emodin results in decreased expression of ABCC4 mRNA; Emodin results in decreased expression of ABCC4 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC4 protein
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC4 mRNA]

PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily C member 6

increases expression

Emodin results in increased expression of ABCC6 mRNA

NCBI chr 1:105,583,681...105,637,895
Ensembl chr 1:96,447,251...96,501,464

G

actin, alpha 1, skeletal muscle

decreases expression

Emodin results in decreased expression of ACTA1 mRNA

NCBI chr19:68,781,168...68,784,194
Ensembl chr19:51,883,715...51,886,742

G

actin alpha 2, smooth muscle

decreases expression
multiple interactions

Emodin results in decreased expression of ACTA2 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]

PMID:15288473 PMID:27989784

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

adhesion G protein-coupled receptor E1

multiple interactions

Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 protein]

NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,242,474...2,398,000

G

angiotensinogen

multiple interactions

Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]; Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977

G

aryl hydrocarbon receptor

multiple interactions

Emodin binds to and results in increased activity of AHR protein
Emodin binds to and results in increased activity of AHR protein; Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

PMID:14644660 PMID:17869316

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1 member B10

decreases activity

Emodin results in decreased activity of AKR1B10 protein

NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C3

decreases activity

Emodin results in decreased activity of AKR1C3 protein

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873

G

aldo-keto reductase family 7 member A3

decreases activity

Emodin results in decreased activity of AKR7A3 protein

NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:151,584,479...151,601,394

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation
decreases expression

[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of AKT1 protein; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; SB 203580 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]; U 0126 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]
AKT activator SC79 inhibits the reaction [Emodin results in decreased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]
Emodin results in decreased expression of AKT1 mRNA

PMID:15288473 PMID:16045814 PMID:17077332 PMID:23848338 PMID:27032576 More...

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

decreases phosphorylation
multiple interactions

Emodin results in decreased phosphorylation of AKT2 protein
AKT activator SC79 inhibits the reaction [Emodin results in decreased phosphorylation of AKT2 protein]

NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817

G

AKT serine/threonine kinase 3

decreases phosphorylation
multiple interactions

Emodin results in decreased phosphorylation of AKT3 protein
AKT activator SC79 inhibits the reaction [Emodin results in decreased phosphorylation of AKT3 protein]

NCBI chr13:91,475,839...91,758,060
Ensembl chr13:88,946,091...89,225,708

G

androgen receptor

multiple interactions

Emodin inhibits the reaction [cobaltous chloride results in increased expression of AR protein]

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925

G

arginase 2

decreases expression

Emodin results in decreased expression of ARG2 mRNA

NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:97,936,002...97,961,378

G

AT-rich interaction domain 3A

increases expression

Emodin results in increased expression of ARID3A mRNA

NCBI chr 7:10,403,161...10,431,551
Ensembl chr 7:9,755,294...9,780,599

G

ATM serine/threonine kinase

increases expression
increases phosphorylation

Emodin results in increased expression of ATM mRNA
Emodin results in increased phosphorylation of ATM protein

PMID:16045814 PMID:20855424

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

BAG cochaperone 5

decreases expression

Emodin results in decreased expression of BAG5 mRNA

NCBI chr 6:136,589,623...136,593,278
Ensembl chr 6:130,768,141...130,772,970

G

BCL2 associated X, apoptosis regulator

affects expression
increases expression
multiple interactions
decreases expression

Emodin affects the expression of BAX protein
Emodin results in increased expression of BAX protein
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside promotes the reaction [Emodin results in increased expression of BAX protein]
Emodin results in decreased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BAX protein]; SB 203580 affects the reaction [Emodin affects the expression of BAX protein]; U 0126 affects the reaction [Emodin affects the expression of BAX protein]

PMID:19549930 PMID:27032576 PMID:35753641

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions
affects expression

Emodin results in decreased expression of BCL2 mRNA; Emodin results in decreased expression of BCL2 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of BCL2 protein
Emodin affects the expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BCL2 protein]; SB 203580 affects the reaction [Emodin affects the expression of BCL2 protein]; U 0126 affects the reaction [Emodin affects the expression of BCL2 protein]

PMID:19549930 PMID:23848338 PMID:27032576 PMID:35753641

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bifunctional apoptosis regulator

decreases expression

Emodin results in decreased expression of BFAR mRNA

NCBI chr10:2,059,189...2,092,207
Ensembl chr10:1,552,072...1,585,038

G

BH3 interacting domain death agonist

increases degradation
multiple interactions

Emodin results in increased degradation of BID protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased degradation of BID protein]; SB 203580 promotes the reaction [Emodin results in increased degradation of BID protein]

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 5

decreases expression

Emodin results in decreased expression of BIRC5 mRNA; Emodin results in decreased expression of BIRC5 protein

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

calnexin

decreases expression

Emodin results in decreased expression of CANX mRNA

NCBI chr10:35,124,941...35,157,954
Ensembl chr10:34,625,191...34,656,821

G

caspase 1

increases expression
multiple interactions

Emodin results in increased expression of CASP1 mRNA
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased cleavage of CASP1 protein]

PMID:15612046 PMID:37023836

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383

G

caspase 12

decreases expression

Emodin results in decreased expression of CASP12 mRNA

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

increases expression
multiple interactions
affects expression
increases cleavage
increases activity

Emodin results in increased expression of CASP3 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased cleavage of CASP3 protein; Emodin inhibits the reaction [Hydrogen Peroxide results in decreased expression of and results in increased cleavage of CASP3 protein]; Emodin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Emodin inhibits the reaction [Oxidopamine results in decreased expression of and results in increased cleavage of CASP3 protein]; Emodin inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]
Emodin affects the expression of CASP3 protein modified form
Emodin results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of CASP3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Emodin results in increased activity of CASP3 protein]; Emodin results in increased cleavage of and results in increased activity of CASP3 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of CASP3 protein]; U 0126 promotes the reaction [Emodin results in increased cleavage of CASP3 protein]

PMID:19549930 PMID:23848338 PMID:25448808 PMID:27032576 PMID:34492313 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions
increases activity

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein]; SB 203580 promotes the reaction [Emodin results in increased activity of CASP8 protein]; U 0126 promotes the reaction [Emodin results in increased activity of CASP8 protein]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases expression
multiple interactions

Emodin results in increased expression of CASP9 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased cleavage of CASP9 protein

PMID:21319176 PMID:35753641

Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
affects expression

Emodin inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein]
Emodin promotes the reaction [Cisplatin results in decreased activity of CAT protein]
Emodin affects the expression of CAT protein

PMID:19549930 PMID:22271272 PMID:26139382

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 1

decreases activity

Emodin results in decreased activity of CBR1 protein

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

C-C motif chemokine ligand 26

multiple interactions

Emodin inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein]

NCBI chr12:26,745,972...26,750,924
Ensembl chr12:21,109,421...21,114,335

G

cyclin B2

decreases expression

Emodin results in decreased expression of CCNB2 mRNA

NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:71,087,595...71,100,874

G

C-C motif chemokine receptor 3

multiple interactions

Emodin inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein]

NCBI chr 8:132,463,533...132,511,601
Ensembl chr 8:123,616,236...123,634,990

G

cadherin 1

increases expression
multiple interactions

Emodin results in increased expression of CDH1 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase 13

decreases expression

Emodin results in decreased expression of CDK13 mRNA

NCBI chr17:51,945,975...52,040,218
Ensembl chr17:47,251,163...47,341,721

G

cyclin-dependent kinase 4

decreases expression

Emodin results in decreased expression of CDK4 mRNA

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1C

increases expression

Emodin results in increased expression of CDKN1C mRNA

NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:198,655,407...198,658,048

G

cadherin, EGF LAG seven-pass G-type receptor 3

decreases expression

Emodin results in decreased expression of CELSR3 mRNA

NCBI chr 8:118,409,136...118,438,593
Ensembl chr 8:109,530,641...109,558,354

G

chitinase, acidic

multiple interactions

Emodin inhibits the reaction [Ovalbumin results in increased expression of CHIA mRNA]

NCBI chr 2:196,302,687...196,344,849
Ensembl chr 2:193,614,114...193,656,533

G

cell death-inducing DFFA-like effector c

decreases expression

Emodin results in decreased expression of CIDEC mRNA

NCBI chr 4:148,124,924...148,137,806
Ensembl chr 4:146,569,289...146,582,173

G

collagen type I alpha 1 chain

decreases expression

Emodin results in decreased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

multiple interactions

Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867

G

collagen type III alpha 1 chain

decreases expression

Emodin results in decreased expression of COL3A1 mRNA

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547

G

COP9 signalosome subunit 5

multiple interactions

[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein

NCBI chr 5:13,975,198...13,993,391
Ensembl chr 5:9,192,100...9,210,731

G

casein kinase 2 alpha 1

increases expression

Emodin results in increased expression of CSNK2A1 mRNA

NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:140,709,991...140,756,696

G

casein kinase 2 beta

increases expression

Emodin results in increased expression of CSNK2B mRNA

NCBI chr20:3,704,833...3,709,999
Ensembl chr20:3,698,733...3,707,133

G

cathepsin D

decreases expression

Emodin results in decreased expression of CTSD mRNA

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488

G

C-X-C motif chemokine ligand 1

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA]

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 2

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA]

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075

G

CYLD lysine 63 deubiquitinase

increases expression

Emodin results in increased expression of CYLD mRNA

NCBI chr19:34,487,491...34,547,311
Ensembl chr19:18,314,019...18,373,658

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
increases expression

Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Emodin results in decreased activity of CYP1A1 protein
Emodin results in increased expression of CYP1A1 mRNA; Emodin results in increased expression of CYP1A1 protein

PMID:11502733 PMID:14644660 PMID:17012224 PMID:27633141

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases hydroxylation
increases oxidation
decreases activity

[CYP1A2 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
CYP1A2 protein results in increased hydroxylation of Emodin
CYP1A2 protein results in increased oxidation of Emodin
Emodin results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:27989148 PMID:30672276 PMID:33438235

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression
decreases activity

Emodin results in increased expression of CYP1B1 mRNA; Emodin results in increased expression of CYP1B1 protein
Emodin results in decreased activity of CYP1B1 protein

PMID:11502733 PMID:14990334 PMID:27633141

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression
multiple interactions

Emodin results in decreased expression of CYP27A1 mRNA
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of CYP27A1 protein

PMID:28161596 PMID:30517764 PMID:35753641

NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases oxidation
decreases activity
multiple interactions

CYP2C19 protein results in increased oxidation of Emodin
Emodin results in decreased activity of CYP2C19 protein
[CYP2C19 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite

PMID:27989148 PMID:33438235

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

Emodin results in decreased activity of CYP2D6 protein

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases activity
affects response to substance
increases hydroxylation
increases oxidation

[CYP3A4 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
Emodin results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the susceptibility to Emodin
CYP3A4 protein results in increased hydroxylation of Emodin
CYP3A4 protein results in increased oxidation of Emodin

PMID:27989148 PMID:30672276 PMID:33438235 PMID:34875353

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases hydroxylation

CYP3A5 protein results in increased hydroxylation of Emodin

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450 family 7 subfamily A member 1

decreases expression
multiple interactions

Emodin results in decreased expression of CYP7A1 mRNA; Emodin results in decreased expression of CYP7A1 protein
[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of CYP7A1 protein

PMID:28161596 PMID:35753641

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 7 subfamily B member 1

decreases expression

Emodin results in decreased expression of CYP7B1 mRNA

NCBI chr 2:102,419,011...102,586,047
Ensembl chr 2:100,502,791...100,669,698

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

Emodin results in decreased expression of CYP8B1 mRNA; Emodin results in decreased expression of CYP8B1 protein

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:121,557,062...121,580,166

G

dopachrome tautomerase

decreases expression

Emodin results in decreased expression of DCT mRNA; Emodin results in decreased expression of DCT protein

NCBI chr15:101,469,159...101,508,029
Ensembl chr15:95,062,003...95,100,836

G

DNA-damage inducible transcript 3

increases expression

Emodin results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

dihydrofolate reductase

decreases expression

Emodin results in decreased expression of DHFR mRNA

NCBI chr 2:25,320,895...25,346,004
Ensembl chr 2:23,586,031...23,613,713

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression

Emodin results in increased expression of DNAJB1 mRNA

NCBI chr19:41,427,453...41,431,141
Ensembl chr19:24,522,717...24,526,458

G

dynein cytoplasmic 1 heavy chain 1

increases expression

Emodin results in increased expression of DYNC1H1 mRNA

NCBI chr 6:135,436,375...135,502,117
Ensembl chr 6:129,609,397...129,680,883

G

E2F transcription factor 5

increases expression

Emodin results in increased expression of E2F5 mRNA

NCBI chr 2:88,718,567...88,734,143
Ensembl chr 2:86,997,332...87,012,990

G

early growth response 1

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of EGR1 mRNA]

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

EI24, autophagy associated transmembrane protein

increases expression

Emodin results in increased expression of EI24 mRNA

NCBI chr 8:44,683,138...44,699,502
Ensembl chr 8:36,494,289...36,510,571

G

eukaryotic translation initiation factor 2B subunit alpha

decreases expression

Emodin results in decreased expression of EIF2B1 mRNA

NCBI chr12:37,686,149...37,694,830
Ensembl chr12:32,025,557...32,046,601

G

estrogen receptor 1

increases activity

Emodin results in increased activity of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases activity

Emodin results in increased activity of ESR2 protein

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919

G

fatty acid binding protein 5

decreases expression

Emodin results in decreased expression of FABP5 mRNA

NCBI chr 2:93,672,451...93,676,186
Ensembl chr 2:91,765,056...91,853,773

G

Fas associated via death domain

increases expression

Emodin results in increased expression of FADD mRNA

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:199,739,994...199,745,653

G

Fas cell surface death receptor

multiple interactions
decreases expression
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FAS protein]; U 0126 promotes the reaction [Emodin results in increased expression of FAS protein]
Emodin results in decreased expression of FAS protein

PMID:19549930 PMID:27032576

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FASLG protein]; SB 203580 promotes the reaction [Emodin results in increased expression of FASLG protein]; U 0126 promotes the reaction [Emodin results in increased expression of FASLG protein]

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215

G

fibronectin 1

decreases expression

Emodin results in decreased expression of FN1 mRNA

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678

G

forkhead box O1

increases expression

Emodin results in increased expression of FOXO1 mRNA

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GADD45A mRNA]

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115

G

growth arrest-specific 2

increases expression

Emodin results in increased expression of GAS2 mRNA

NCBI chr 1:110,587,952...110,721,572
Ensembl chr 1:101,482,591...101,582,619

G

glutamate-cysteine ligase, catalytic subunit

increases expression

Emodin results in increased expression of GCLC mRNA

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

Emodin results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535

G

glucosaminyl (N-acetyl) transferase 2

increases expression

Emodin results in increased expression of GCNT2 mRNA

NCBI chr17:24,002,592...24,107,339
Ensembl chr17:23,796,859...23,901,611

G

glial fibrillary acidic protein

multiple interactions

Emodin inhibits the reaction [Oxaliplatin results in increased expression of GFAP protein]; Emodin inhibits the reaction [TNF protein results in increased expression of GFAP protein]

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589

G

golgin A3

increases expression

Emodin results in increased expression of GOLGA3 mRNA

NCBI chr12:52,112,129...52,160,311
Ensembl chr12:46,454,870...46,500,509
Ensembl chr 4:46,454,870...46,500,509

G

glutamic--pyruvic transaminase

multiple interactions

[Emodin co-treated with 1-aminobenzotriazole] results in increased expression of GPT protein; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein]

PMID:34492313 PMID:37023836

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

increases expression

Emodin results in increased expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPX2 mRNA]

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 4

decreases expression
multiple interactions

Emodin results in decreased expression of GPX4 mRNA; Emodin results in decreased expression of GPX4 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of GPX4 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of GPX4 protein]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of GPX4 mRNA]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of GPX4 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of GPX4 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of GPX4 protein]

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:9,650,185...9,652,982

G

glutathione-disulfide reductase

multiple interactions

Emodin promotes the reaction [Cisplatin results in decreased activity of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase, mu 5

decreases expression

Emodin results in decreased expression of GSTM3 mRNA

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:195,531,495...195,534,553

G

glutathione S-transferase pi 1

multiple interactions

Emodin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226

G

H2A.X variant histone

increases expression
multiple interactions

Emodin results in increased expression of H2AX protein; Emodin results in increased expression of H2AX protein modified form
TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]

PMID:20855424 PMID:34492313 PMID:36893906

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

3-hydroxyacyl-CoA dehydratase 3

decreases expression

Emodin results in decreased expression of HACD3 mRNA

NCBI chr 8:74,396,441...74,433,700
Ensembl chr 8:65,501,240...65,538,507

G

hes family bHLH transcription factor 1

decreases expression
multiple interactions

Emodin results in decreased expression of HES1 mRNA; Emodin results in decreased expression of HES1 protein
JAG1 protein inhibits the reaction [Emodin results in decreased expression of HES1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HES1 protein]

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA]

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

histone linker H1 domain, spermatid-specific 1

increases expression

Emodin results in increased expression of H1F9 mRNA

NCBI chr10:80,410,361...80,411,157
Ensembl chr10:79,913,480...79,914,321

G

hexokinase 2

increases expression

Emodin results in increased expression of HK2 mRNA

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:115,234,509...115,283,530

G

heme oxygenase 1

multiple interactions
decreases expression
increases expression

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 protein]
Emodin results in decreased expression of HMOX1 mRNA; Emodin results in decreased expression of HMOX1 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of HMOX1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of HMOX1 protein]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of HMOX1 mRNA]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of HMOX1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HMOX1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HMOX1 protein]
Emodin results in increased expression of HMOX1 mRNA

PMID:26139382 PMID:30517764 PMID:34875353 PMID:37393915

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

hepatocyte nuclear factor 4, alpha

decreases expression
affects glucuronidation

Emodin results in decreased expression of HNF4A protein
Emodin results in decreased expression of HNF4A mRNA; Emodin results in decreased expression of HNF4A protein
HNF4A gene SNP affects the glucuronidation of Emodin

NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:152,186,787...152,248,320

G

heat shock protein family A (Hsp70) member 5

increases expression

Emodin results in increased expression of HSPA5 protein

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891

G

intercellular adhesion molecule 1

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

immunoglobulin superfamily, member 11

increases expression

Emodin results in increased expression of IGSF11 mRNA

NCBI chr11:75,238,706...75,389,748
Ensembl chr11:61,733,144...61,868,348

G

interleukin 10

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL10 mRNA]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

multiple interactions

Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein]

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737

G

interleukin 15

increases expression

Emodin results in increased expression of IL15 mRNA

NCBI chr19:42,536,160...42,611,349
Ensembl chr19:25,640,251...25,706,820

G

interleukin 18

multiple interactions

Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL18 protein]

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL1B protein]
Emodin inhibits the reaction [Oxaliplatin results in increased expression of IL1B protein]; Emodin inhibits the reaction [TNF protein results in increased expression of IL1B protein]

PMID:26139382 PMID:30517764 PMID:36184831 PMID:37023836

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

multiple interactions

Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

multiple interactions

Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein]

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein]
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]

PMID:18590720 PMID:23848338 PMID:26139382 PMID:30517764 PMID:37023836

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

inositol 1,4,5-trisphosphate receptor, type 1

decreases expression

Emodin results in decreased expression of ITPR1 mRNA

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491

G

jagged canonical Notch ligand 1

multiple interactions
decreases expression

2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of and results in decreased cleavage of NOTCH1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of GPX4 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of GPX4 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HES1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HES1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HMOX1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of HMOX1 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NFE2L2 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NQO1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NQO1 protein]; JAG1 protein inhibits the reaction [Emodin results in increased expression of PTGS2 mRNA]; JAG1 protein inhibits the reaction [Emodin results in increased expression of TP53 protein]
Emodin results in decreased expression of JAG1 protein

PMID:27989784 PMID:37393915

NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:124,406,794...124,442,209

G

Janus kinase 1

decreases phosphorylation
multiple interactions

Emodin results in decreased phosphorylation of JAK1 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

decreases phosphorylation
multiple interactions

Emodin results in decreased phosphorylation of JAK2 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,734,122...18,735,799

G

keratin 19

decreases expression

Emodin results in decreased expression of KRT19 mRNA

NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,066,802...85,171,799

G

lysosomal protein transmembrane 5

increases expression

Emodin results in increased expression of LAPTM5 mRNA

NCBI chr 5:148,371,880...148,393,927
Ensembl chr 5:143,087,759...143,109,807

G

lymphoid enhancer binding factor 1

decreases expression

Emodin results in decreased expression of LEF1 mRNA

NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:219,666,592...219,779,794

G

LDL receptor related protein 1

multiple interactions

[Emodin co-treated with cobaltous chloride] results in increased expression of LRP1 protein

NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:63,380,356...63,460,910

G

microtubule-actin crosslinking factor 1

decreases expression

Emodin results in decreased expression of MACF1 mRNA

NCBI chr 5:140,908,829...141,234,127
Ensembl chr 5:135,623,742...135,945,905

G

monoamine oxidase B

decreases activity

Emodin results in decreased activity of MAOB protein

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:5,907,266...6,011,003

G

mitogen activated protein kinase kinase 1

multiple interactions

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

multiple interactions

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]

NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]
Emodin results in decreased phosphorylation of MAPK1 protein
Emodin results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK1 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with T0901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]

PMID:15288473 PMID:26972667 PMID:27032576

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 10

increases expression

Emodin results in increased expression of MAPK10 mRNA

NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,497,707...6,786,201

G

mitogen activated protein kinase 14

multiple interactions

Acetylcysteine inhibits the reaction [Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]]; Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]
Emodin results in decreased phosphorylation of MAPK3 protein
Emodin results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with T0901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]

PMID:15288473 PMID:26972667 PMID:27032576

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

decreases expression

Emodin results in decreased expression of MAPT mRNA

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression
increases expression

Emodin results in decreased expression of MCL1 mRNA; Emodin results in decreased expression of MCL1 protein
Emodin results in increased expression of MCL1 mRNA

PMID:21319176 PMID:23848338

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303

G

maternal embryonic leucine zipper kinase

decreases expression

Emodin results in decreased expression of MELK mRNA; Emodin results in decreased expression of MELK protein

NCBI chr 5:63,336,151...63,396,254
Ensembl chr 5:58,540,449...58,600,937

G

O-6-methylguanine-DNA methyltransferase

increases expression

Emodin results in increased expression of MGMT mRNA

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756

G

melanocyte inducing transcription factor

decreases expression

Emodin results in decreased expression of MITF protein

NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:130,409,217...130,621,145

G

myeloperoxidase

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

Emodin inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:196,864,336...196,896,475

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
affects expression

Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]
Emodin affects the expression of MYC protein

PMID:17886230 PMID:19549930

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

myosin light chain kinase

increases activity

Emodin results in increased activity of MYLK protein

NCBI chr11:79,288,243...79,535,450
Ensembl chr11:65,783,008...66,030,261

G

nuclear receptor coactivator 2

increases expression

Emodin results in increased expression of NCOA2 mRNA

NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:5,835,706...6,067,451

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases expression
affects localization

Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of NFE2L2 protein]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of NFE2L2 mRNA]; Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein
Emodin results in decreased expression of NFE2L2 mRNA
Emodin affects the localization of NFE2L2 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of NFE2L2 mRNA]; [[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which binds to NFE2L2 protein; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein]; Emodin affects the localization of [PKM protein binds to NFE2L2 protein]; Emodin promotes the reaction [PKM protein binds to NFE2L2 protein]; Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein; JAG1 protein inhibits the reaction [Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NFE2L2 mRNA]

PMID:26139382 PMID:34971761 PMID:37393915

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

increases expression
multiple interactions

Emodin results in increased expression of NFKB1 protein
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NFKB1 mRNA]

PMID:19549930 PMID:37023836

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

increases expression
multiple interactions

Emodin results in increased expression of NFKBIA mRNA
Emodin inhibits the reaction [Ovalbumin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

PMID:16045814 PMID:22484343

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

G

NK6 homeobox 2

increases expression

Emodin results in increased expression of NKX6-2 mRNA

NCBI chr 1:203,811,582...203,813,122
Ensembl chr 1:194,381,975...194,383,515

G

NLR family, pyrin domain containing 3

multiple interactions

Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

multiple interactions
affects expression

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NOS2 protein]
Emodin affects the expression of NOS2

PMID:18590720 PMID:23615023

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 1

decreases expression
multiple interactions
decreases response to substance

Emodin results in decreased expression of NOTCH1 protein
Emodin results in decreased expression of and results in decreased cleavage of NOTCH1 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; Emodin results in decreased expression of and results in decreased cleavage of NOTCH1 protein; JAG1 protein inhibits the reaction [Emodin results in decreased expression of and results in decreased cleavage of NOTCH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein]
NOTCH1 protein results in decreased susceptibility to Emodin

PMID:27989784 PMID:37393915

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531

G

NAD(P)H quinone dehydrogenase 1

increases expression
decreases expression
multiple interactions

Emodin results in increased expression of NQO1 mRNA
Emodin results in decreased expression of NQO1 mRNA; Emodin results in decreased expression of NQO1 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of NQO1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of NQO1 protein]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of NQO1 mRNA]; AKT activator SC79 inhibits the reaction [Emodin results in decreased expression of NQO1 protein]; Emodin results in increased expression of and results in increased activity of NQO1 protein; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NQO1 mRNA]; JAG1 protein inhibits the reaction [Emodin results in decreased expression of NQO1 protein]

PMID:34875353 PMID:34971761 PMID:37393915

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 0, group B, member 2

increases expression

Emodin results in increased expression of NR0B2 mRNA

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group H, member 3

increases expression

Emodin results in increased expression of NR1H3 mRNA; Emodin results in increased expression of NR1H3 protein

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722

G

nuclear receptor subfamily 1, group H, member 4

decreases expression

Emodin results in decreased expression of NR1H4 mRNA; Emodin results in decreased expression of NR1H4 protein

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047

G

OMA1 zinc metallopeptidase

multiple interactions

Emodin inhibits the reaction [Hydrogen Peroxide results in increased expression of OMA1 protein]; Emodin inhibits the reaction [Oxidopamine results in increased expression of OMA1 protein]

NCBI chr 5:123,312,038...123,455,540
Ensembl chr 5:118,083,728...118,136,980

G

poly (ADP-ribose) polymerase 1

increases activity
increases cleavage
multiple interactions

Emodin results in increased activity of PARP1 protein
Emodin results in increased cleavage of PARP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of PARP1 protein]; [U 0126 co-treated with Emodin] results in increased cleavage of PARP1 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]

PMID:23848338 PMID:27032576 PMID:34492313 PMID:36893906

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

multiple interactions

Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

phosducin like

decreases expression

Emodin results in decreased expression of PDCL mRNA

NCBI chr 3:41,519,953...41,529,545
Ensembl chr 3:21,110,167...21,119,715
Ensembl chr 3:21,110,167...21,119,715

G

platelet derived growth factor subunit B

multiple interactions

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984

G

platelet derived growth factor receptor beta

multiple interactions
decreases expression

Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]
Emodin results in decreased expression of PDGFRB protein

NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843

G

platelet and endothelial cell adhesion molecule 1

decreases expression

Emodin results in decreased expression of PECAM1 protein

NCBI chr10:92,090,263...92,152,002
Ensembl chr10:91,590,521...91,652,116

G

phosphatidylinositol 3-kinase, catalytic subunit type 3

increases expression

Emodin results in increased expression of PIK3C3 mRNA

NCBI chr18:22,119,677...22,203,546
Ensembl chr18:21,845,295...21,929,048

G

phosphoinositide-3-kinase regulatory subunit 1

affects expression

Emodin affects the expression of PIK3R1 protein

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631

G

pyruvate kinase M1/2

affects localization
decreases activity
multiple interactions

Emodin affects the localization of PKM protein
Emodin results in decreased activity of PKM protein
[[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which binds to NFE2L2 protein; [[Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]] which results in decreased activity of PKM protein; [Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]] results in increased abundance of [PKM protein binds to PKM protein]; Emodin affects the localization of [PKM protein binds to NFE2L2 protein]; Emodin inhibits the reaction [PKM protein binds to PKM protein binds to PKM protein binds to PKM protein]; Emodin promotes the reaction [PKM protein binds to NFE2L2 protein]

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599

G

peroxisome proliferator-activated receptor gamma

increases expression
multiple interactions

Emodin results in increased expression of PPARG protein
Emodin results in increased stability of and results in increased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

increases expression

Emodin results in increased expression of PPM1D mRNA

NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,172,603...70,208,607

G

protein phosphatase 1, regulatory (inhibitor) subunit 1C

decreases expression

Emodin results in decreased expression of PPP1R1C mRNA

NCBI chr 3:64,616,700...64,719,696
Ensembl chr 3:64,616,700...64,724,104

G

peroxiredoxin 6

increases expression

Emodin results in increased expression of PRDX6 mRNA

NCBI chr13:76,062,082...76,072,631
Ensembl chr13:73,528,210...73,539,355

G

protein kinase C, alpha

affects localization

Emodin affects the localization of PRKCA protein

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, delta

decreases expression
affects expression

Emodin results in decreased expression of PRKCD mRNA
Emodin affects the expression of PRKCD protein

PMID:16045814 PMID:19549930

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352

G

protamine 3

increases expression

Emodin results in increased expression of PRM3 mRNA

NCBI chr10:5,384,394...5,384,908
Ensembl chr10:4,877,471...4,877,985

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

2-tert-butylhydroquinone inhibits the reaction [Emodin results in increased expression of PTGS2 mRNA]; AKT activator SC79 inhibits the reaction [Emodin results in increased expression of PTGS2 mRNA]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of PTGS2 protein]; Emodin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; JAG1 protein inhibits the reaction [Emodin results in increased expression of PTGS2 mRNA]
Emodin results in increased expression of PTGS2 mRNA; Emodin results in increased expression of PTGS2 protein

PMID:36184831 PMID:37393915

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

affects expression

Emodin affects the expression of PTK2 protein

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, non-receptor type 6

increases expression
multiple interactions

Emodin results in increased expression of PTPN6 protein
PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]

NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:157,526,035...157,550,984

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases expression
multiple interactions

Emodin results in decreased expression of RAF1 mRNA
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]

PMID:15288473 PMID:16045814

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317

G

recombination activating 1

decreases expression

Emodin results in decreased expression of RAG1 mRNA

NCBI chr 3:108,372,087...108,383,184
Ensembl chr 3:87,917,004...87,928,291

G

retinoic acid receptor, beta

decreases expression

Emodin results in decreased expression of RARB mRNA

NCBI chr15:10,837,252...11,482,037
Ensembl chr15:8,406,492...9,051,288

G

RB transcriptional corepressor 1

decreases expression

Emodin results in decreased expression of RB1 mRNA

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302

G

reticulocalbin 2

increases expression

Emodin results in increased expression of RCN2 mRNA

NCBI chr 8:65,345,247...65,362,290
Ensembl chr 8:56,449,206...56,466,251

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases localization

Emodin affects the expression of and affects the localization of RELA protein; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased localization of RELA protein]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of RELA protein]; Emodin inhibits the reaction [TNF protein results in increased expression of RELA protein]
Emodin results in decreased localization of RELA protein
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of RELA protein]; Emodin inhibits the reaction [Ovalbumin affects the localization of RELA protein]

PMID:18590720 PMID:19549930 PMID:22484343 PMID:30517764 PMID:36184831 More...

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

ras homolog family member A

decreases expression

Emodin results in decreased expression of RHOA mRNA

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746

G

Rho-associated coiled-coil containing protein kinase 1

decreases expression

Emodin results in decreased expression of ROCK1 mRNA

NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,115,905...1,235,571

G

Rho-associated coiled-coil containing protein kinase 2

decreases expression

Emodin results in decreased expression of ROCK2 mRNA

NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:39,679,082...39,774,031

G

SUMO1 activating enzyme subunit 1

decreases expression

Emodin results in decreased expression of SAE1 mRNA

NCBI chr 1:86,159,114...86,215,089
Ensembl chr 1:77,030,965...77,086,986

G

serpin family E member 1

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 10 member 1

decreases expression
multiple interactions

Emodin results in decreased expression of SLC10A1 mRNA; Emodin results in decreased expression of SLC10A1 protein
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]

PMID:28161596 PMID:30517764

NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 22 member 6

decreases activity

Emodin results in decreased activity of SLC22A6 protein

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

decreases activity

Emodin results in decreased activity of SLC22A8 protein

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier organic anion transporter family member 1B2

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:174,551,480...174,619,981

G

sperm mitochondria-associated cysteine-rich protein

increases expression

Emodin results in increased expression of SMCP mRNA

NCBI chr 2:180,856,561...180,861,564
Ensembl chr 2:178,160,127...178,166,001

G

small nuclear ribonucleoprotein 13

decreases expression

Emodin results in decreased expression of SNU13 mRNA

NCBI chr 7:115,445,415...115,451,008
Ensembl chr 7:113,565,295...113,570,872
Ensembl chr 1:113,565,295...113,570,872

G

superoxide dismutase 1

multiple interactions

Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
affects activity

Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA]
Emodin affects the activity of SOD2 protein

PMID:21382473 PMID:23615023

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

SRC proto-oncogene, non-receptor tyrosine kinase

decreases phosphorylation

Emodin results in decreased phosphorylation of SRC protein

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

increases expression

Emodin results in increased expression of ST8SIA1 mRNA

NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708

G

signal transducer and activator of transcription 3

affects localization
multiple interactions

Emodin affects the localization of STAT3 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein; pervanadate inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

stress-induced phosphoprotein 1

decreases expression

Emodin results in decreased expression of STIP1 mRNA

NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:204,178,932...204,228,476

G

sulfotransferase family 1A member 1

decreases activity

Emodin results in decreased activity of SULT1A1 protein

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:181,272,023...181,275,562

G

SPT20 homolog, SAGA complex component

increases expression

Emodin results in increased expression of SUPT20H mRNA

NCBI chr 2:141,047,479...141,080,656
Ensembl chr 2:138,897,416...138,930,495

G

TAO kinase 3

decreases expression

Emodin results in decreased expression of TAOK3 mRNA

NCBI chr12:44,973,180...45,134,439
Ensembl chr12:39,314,027...39,461,244

G

tubulin folding cofactor C

decreases expression

Emodin results in decreased expression of TBCC mRNA

NCBI chr 9:14,098,855...14,100,043
Ensembl chr 9:14,098,868...14,100,042

G

transcription factor like 5

increases expression

Emodin results in increased expression of TCFL5 mRNA

NCBI chr 3:167,734,471...167,754,174
Ensembl chr 3:167,734,473...167,754,282

G

transforming growth factor, beta 1

multiple interactions
decreases activity

2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin results in decreased activity of TGFB1 protein]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein]

PMID:15288473 PMID:19474275 PMID:27989784

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]; Emodin inhibits the reaction [Oxaliplatin results in increased expression of TNF protein]; Emodin inhibits the reaction [TNF protein results in increased expression of GFAP protein]; Emodin inhibits the reaction [TNF protein results in increased expression of IL1B protein]; Emodin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Emodin inhibits the reaction [TNF protein results in increased expression of RELA protein]
Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of TNF protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]

PMID:14534369 PMID:15313406 PMID:18590720 PMID:26139382 PMID:36184831 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

DNA topoisomerase II alpha

multiple interactions
increases activity

Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate]; TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]
Emodin results in increased activity of TOP2A protein

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

affects expression
multiple interactions
increases expression

Emodin affects the expression of TP53 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in increased expression of TP53 protein]; AKT activator SC79 inhibits the reaction [Emodin results in increased expression of TP53 protein]; JAG1 protein inhibits the reaction [Emodin results in increased expression of TP53 protein]

PMID:19549930 PMID:37393915

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p63

increases expression

Emodin results in increased expression of TRP63 mRNA

NCBI chr11:88,343,647...88,554,543
Ensembl chr11:74,838,859...75,049,398

G

Tnf receptor-associated factor 2

increases expression
decreases expression

Emodin results in increased expression of TRAF2 mRNA
Emodin results in decreased expression of TRAF2 mRNA

PMID:16045814 PMID:21319176

NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:8,341,951...8,366,538

G

transient receptor potential cation channel, subfamily V, member 2

increases expression

Emodin results in increased expression of TRPV2 mRNA

NCBI chr10:47,772,223...47,797,956
Ensembl chr10:47,272,931...47,294,260

G

testis specific, 13

increases expression

Emodin results in increased expression of TSGA13 mRNA

NCBI chr 4:59,501,773...59,522,925
Ensembl chr 4:59,501,774...59,522,818

G

tubulin, beta 3 class III

decreases expression

Emodin results in decreased expression of TUBB3 mRNA

NCBI chr19:68,365,687...68,374,741
Ensembl chr19:51,457,184...51,466,243

G

thioredoxin 1

multiple interactions

Emodin results in increased expression of and results in increased activity of TXN protein

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin-like 4B

decreases expression

Emodin results in decreased expression of TXNL4B mRNA

NCBI chr19:37,530,157...37,539,827
Ensembl chr19:37,530,152...37,538,521

G

thioredoxin reductase 1

decreases expression
multiple interactions

Emodin results in decreased expression of TXNRD1 mRNA
Emodin results in increased expression of and results in increased activity of TXNRD1 protein

PMID:16045814 PMID:34971761

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863

G

tyrosinase

decreases activity

Emodin results in decreased activity of TYR protein

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207

G

tyrosinase-related protein 1

decreases expression

Emodin results in decreased expression of TYRP1 mRNA; Emodin results in decreased expression of TYRP1 protein

NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:95,280,982...95,299,516

G

ubiquitin-conjugating enzyme E2I

increases expression

Emodin results in increased expression of UBE2I mRNA

NCBI chr10:14,782,245...14,802,911
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of Emodin

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of Emodin

PMID:14557274 PMID:24854283

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of Emodin

NCBI chr14:21,122,866...21,138,450
Ensembl chr14:20,768,015...20,783,589

G

UDP glucuronosyltransferase family 2 member B7

decreases expression

Emodin results in decreased expression of UGT2B7 mRNA; Emodin results in decreased expression of UGT2B7 protein

NCBI chr14:21,251,535...21,274,451
Ensembl chr14:20,896,682...20,919,604

G

voltage-dependent anion channel 1

decreases expression

Emodin results in decreased expression of VDAC1 mRNA

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:36,532,244...36,559,640

G

vascular endothelial growth factor A

decreases expression

Emodin results in decreased expression of VEGFA mRNA; Emodin results in decreased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

decreases expression
multiple interactions

Emodin results in decreased expression of VIM protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187

G

X-ray repair cross complementing 1

affects expression

Emodin affects the expression of XRCC1 protein

NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:80,141,207...80,168,701

G

zinc finger protein 37

increases expression

Emodin results in increased expression of ZFP37 mRNA

NCBI chr 5:75,598,732...75,638,896
Ensembl chr 5:75,598,732...75,638,942

Macrosporin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

DNA topoisomerase II alpha

decreases activity

macrosporin results in decreased activity of TOP2A protein

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874

mitoxantrone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

affects response to substance

ABCA1 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

increases expression

Mitoxantrone results in increased expression of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily G member 2

affects export
affects response to substance
increases transport
multiple interactions
increases export
increases expression
decreases abundance
decreases response to substance
increases response to substance
affects transport
affects uptake

ABCG2 protein affects the export of Mitoxantrone
ABCG2 protein affects the susceptibility to Mitoxantrone
ABCG2 protein results in increased transport of Mitoxantrone
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] inhibits the reaction [Folic Acid deficiency results in decreased susceptibility to Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; [5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; [Folic Acid deficiency results in increased expression of ABCG2 protein] which results in decreased susceptibility to Mitoxantrone; [GSK 1363089 results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; [Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [MLN 8237 affects the activity of ABCG2 protein] which affects the export of Mitoxantrone; [Novobiocin results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone; Beclomethasone inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Cadmium Chloride inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Dactinomycin inhibits the reaction [Mitoxantrone results in increased expression of ABCG2 mRNA]; desisobutyrylciclesonide inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 gene mutant form results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; GSK 1363089 inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Haloperidol inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Novobiocin inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Olanzapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; oxfendazole inhibits the reaction [ABCG2 protein affects the transport of Mitoxantrone]; Paliperidone Palmitate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Protons promotes the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Quetiapine Fumarate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Risperidone inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein affects the uptake of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mitoxantrone results in increased expression of ABCG2 mRNA; Mitoxantrone results in increased expression of ABCG2 protein
ABCG2 protein results in decreased abundance of Mitoxantrone
ABCG2 protein results in increased susceptibility to Mitoxantrone

PMID:10606239 PMID:12869632 PMID:15239124 PMID:15640379 PMID:15695404 More...

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409

G

acyl-CoA dehydrogenase, very long chain

decreases expression

Mitoxantrone results in decreased expression of ACADVL protein

NCBI chr10:55,231,558...55,236,786
Ensembl chr10:54,732,469...54,738,075

G

acyl-CoA synthetase long-chain family member 3

affects response to substance

ACSL3 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:80,115,112...80,164,627

G

actin, alpha 1, skeletal muscle

decreases expression

Mitoxantrone results in decreased expression of ACTA1 mRNA

PMID:26537877 PMID:28940058

NCBI chr19:68,781,168...68,784,194
Ensembl chr19:51,883,715...51,886,742

G

actin gamma 2, smooth muscle

affects response to substance

ACTG2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:117,579,513...117,604,379
Ensembl chr 4:116,021,832...116,046,465

G

adenosine deaminase, RNA-specific, B1

affects response to substance

ADARB1 protein affects the susceptibility to Mitoxantrone

NCBI chr20:11,222,171...11,350,416
Ensembl chr20:11,222,583...11,350,852

G

1-acylglycerol-3-phosphate O-acyltransferase 5

affects response to substance

AGPAT5 protein affects the susceptibility to Mitoxantrone

NCBI chr16:77,641,887...77,688,148
Ensembl chr16:70,943,135...70,985,560

G

adenosylhomocysteinase-like 1

affects response to substance

AHCYL1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:197,982,335...198,016,770
Ensembl chr 2:195,294,153...195,345,815

G

aldehyde dehydrogenase 2 family member

affects response to substance

ALDH2 protein affects the susceptibility to Mitoxantrone

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521

G

angiomotin-like 1

affects response to substance

AMOTL1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 8:19,630,139...19,749,027
Ensembl chr 8:11,353,674...11,467,573

G

ankyrin 2

decreases expression

Mitoxantrone results in decreased expression of ANK2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 2:218,052,555...218,628,414
Ensembl chr 2:215,379,680...215,862,923

G

asparagine synthetase (glutamine-hydrolyzing)

affects response to substance

ASNS protein affects the susceptibility to Mitoxantrone

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:35,785,237...35,803,423

G

argininosuccinate synthase 1

affects response to substance

ASS1 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:14,747,368...14,796,903

G

autophagy related 5

decreases expression

Mitoxantrone results in decreased expression of ATG5 protein

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209

G

ATM serine/threonine kinase

decreases expression
increases phosphorylation
multiple interactions

Mitoxantrone results in decreased expression of ATM mRNA
Mitoxantrone results in increased phosphorylation of ATM protein
[Poly(ADP-ribose) Polymerase Inhibitors co-treated with Mitoxantrone] results in increased phosphorylation of ATM protein

PMID:22832221 PMID:29913208

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

ATPase Na+/K+ transporting subunit alpha 2

decreases expression

Mitoxantrone results in decreased expression of ATP1A2 mRNA

PMID:26537877 PMID:28940058

NCBI chr13:87,261,964...87,286,911
Ensembl chr13:84,729,601...84,754,544

G

ATP synthase F1 subunit alpha

decreases expression

Mitoxantrone results in decreased expression of ATP5F1A protein

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:71,292,374...71,300,794

G

ATP synthase F1 subunit beta

decreases expression

Mitoxantrone results in decreased expression of ATP5F1B protein

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:515,460...567,273

G

ATP synthase F1 subunit gamma

decreases expression

Mitoxantrone results in decreased expression of ATP5F1C protein

NCBI chr17:73,333,584...73,355,872
Ensembl chr17:68,423,909...68,608,367

G

ATPase copper transporting alpha

decreases response to substance

ATP7A protein results in decreased susceptibility to Mitoxantrone

NCBI chr X:75,159,635...75,267,094
Ensembl chr X:71,094,202...71,198,354

G

beta-secretase 2

affects response to substance

BACE2 protein affects the susceptibility to Mitoxantrone

NCBI chr11:50,176,852...50,258,948
Ensembl chr11:36,707,458...36,789,546

G

BCL2 associated X, apoptosis regulator

increases expression

Mitoxantrone results in increased expression of BAX mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BBX high mobility group box domain containing

affects response to substance

BBX protein affects the susceptibility to Mitoxantrone

NCBI chr11:63,850,034...64,097,700
Ensembl chr11:50,381,247...50,623,251

G

basal cell adhesion molecule (Lutheran blood group)

affects response to substance

BCAM protein affects the susceptibility to Mitoxantrone

NCBI chr 1:88,542,971...88,557,358
Ensembl chr 1:79,415,017...79,429,403

G

branched chain amino acid transaminase 1

increases expression

Mitoxantrone results in increased expression of BCAT1 mRNA

NCBI chr 4:179,695,662...179,777,973
Ensembl chr 4:177,964,834...178,046,597

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]
Mitoxantrone results in decreased expression of BCL2 mRNA

PMID:8219202 PMID:8840993 PMID:15582267

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

beclin 1

decreases expression

Mitoxantrone results in decreased expression of BECN1 protein

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742

G

baculoviral IAP repeat-containing 2

decreases expression

Mitoxantrone results in decreased expression of BIRC2 protein

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 5

affects expression
increases expression

Mitoxantrone affects the expression of BIRC5 mRNA
Mitoxantrone results in increased expression of BIRC5 protein

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein 7

affects response to substance

BMP7 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:161,516,462...161,716,788

G

bone marrow stromal cell antigen 2

affects response to substance

BST2 protein affects the susceptibility to Mitoxantrone

NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,217,407...18,220,979

G

BTB domain containing 3

affects response to substance

BTBD3 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:146,044,053...146,074,189
Ensembl chr 3:125,591,490...125,619,038

G

calcium voltage-gated channel subunit alpha1 G

decreases expression

Mitoxantrone results in decreased expression of CACNA1G mRNA

PMID:26537877 PMID:28940058

NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,355,008...79,422,752

G

calcium voltage-gated channel auxiliary subunit alpha2delta 2

decreases expression

Mitoxantrone results in decreased expression of CACNA2D2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 8:116,950,860...117,082,159
Ensembl chr 8:108,072,454...108,203,173

G

calreticulin

affects localization

Mitoxantrone affects the localization of CALR protein

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414

G

calcium/calmodulin-dependent protein kinase II inhibitor 1

affects response to substance

CAMK2N1 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:155,958,116...155,959,897
Ensembl chr 5:150,673,507...150,676,600

G

CASC3 exon junction complex subunit

affects response to substance

CASC3 mRNA affects the susceptibility to Mitoxantrone

NCBI chr10:84,264,157...84,286,639
Ensembl chr10:83,769,001...83,788,966

G

caspase 2

increases expression
increases splicing

Mitoxantrone results in increased expression of CASP2 mRNA alternative form
Mitoxantrone results in increased splicing of CASP2 mRNA

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

multiple interactions
increases activity

BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP3 protein]
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]

PMID:8840993 PMID:12948851 PMID:16215684 PMID:22700542 PMID:32894303

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

increases activity

Mitoxantrone results in increased activity of CASP6 protein

NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

increases activity
multiple interactions

Mitoxantrone results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP7 protein]

PMID:12948851 PMID:22700542

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

increases activity

Mitoxantrone results in increased activity of CASP8 protein

PMID:12948851 PMID:32894303

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity

Mitoxantrone results in increased activity of CASP9 protein

Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases activity

Mitoxantrone results in decreased activity of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

caveolae associated protein 3

affects response to substance

CAVIN3 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:169,238,384...169,239,973
Ensembl chr 1:159,826,549...159,828,161

G

caveolae associated protein 4

decreases expression

Mitoxantrone results in decreased expression of CAVIN4 mRNA

PMID:26537877 PMID:28940058

NCBI chr 5:67,792,171...67,893,094
Ensembl chr 5:62,996,865...63,007,678

G

CD55 molecule (Cromer blood group)

affects response to substance

CD55 protein affects the susceptibility to Mitoxantrone

NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831

G

CUGBP, Elav-like family member 2

affects response to substance

CELF2 protein affects the susceptibility to Mitoxantrone

NCBI chr17:75,813,928...76,639,300
Ensembl chr17:71,210,853...71,728,333

G

centrosomal protein 15

affects response to substance

CEP15 protein affects the susceptibility to Mitoxantrone

NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838

G

carboxylesterase 2H

affects response to substance

CES2 protein affects the susceptibility to Mitoxantrone

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830

G

chordin-like 1

affects response to substance

CHRDL1 protein affects the susceptibility to Mitoxantrone

NCBI chr X:111,685,864...111,789,684
Ensembl chr X:106,889,125...106,992,921

G

chemokine-like factor

affects response to substance

CKLF protein affects the susceptibility to Mitoxantrone

NCBI chr19:704,528...712,998
Ensembl chr19:698,033...706,570

G

creatine kinase, M-type

decreases expression

Mitoxantrone results in decreased expression of CKM mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:79,061,456...79,071,720

G

chloride nucleotide-sensitive channel 1A

affects response to substance

CLNS1A protein affects the susceptibility to Mitoxantrone

NCBI chr 1:152,019,369...152,039,670
Ensembl chr 1:152,019,378...152,039,661

G

clusterin

affects response to substance

CLU protein affects the susceptibility to Mitoxantrone

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315

G

cochlin

affects response to substance

COCH protein affects the susceptibility to Mitoxantrone

NCBI chr 6:74,766,485...74,780,504
Ensembl chr 6:69,031,167...69,045,109

G

collagen type XI alpha 1 chain

affects response to substance

COL11A1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:204,509,136...204,702,264
Ensembl chr 2:201,820,715...202,013,853

G

corin, serine peptidase

decreases expression

Mitoxantrone results in decreased expression of CORIN mRNA

PMID:26537877 PMID:28940058

NCBI chr14:36,034,613...36,264,671
Ensembl chr14:35,681,304...35,909,503

G

carboxypeptidase, vitellogenic-like

affects response to substance

CPVL protein affects the susceptibility to Mitoxantrone

NCBI chr 4:84,311,853...84,422,098
Ensembl chr 4:82,981,422...83,085,655

G

cAMP responsive element binding protein-like 2

affects response to substance

CREBL2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:169,404,630...169,430,618
Ensembl chr 4:167,673,315...167,699,292

G

citrate synthase

decreases activity

Mitoxantrone results in decreased activity of CS protein

NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:758,345...791,421

G

cysteine and serine rich nuclear protein 2

affects response to substance

CSRNP2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 7:133,473,027...133,488,868
Ensembl chr 7:131,594,232...131,610,075

G

cystathionine gamma-lyase

affects response to substance

CTH protein affects the susceptibility to Mitoxantrone

NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:246,975,894...247,002,234

G

CXADR, Ig-like cell adhesion molecule

affects response to substance

CXADR protein affects the susceptibility to Mitoxantrone

NCBI chr11:30,469,778...30,516,990
Ensembl chr11:16,982,860...17,030,046

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

Mitoxantrone results in decreased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Mitoxantrone results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

death associated protein kinase 1

affects response to substance

DAPK1 protein affects the susceptibility to Mitoxantrone

NCBI chr17:3,935,826...4,096,858
Ensembl chr17:3,930,213...4,090,991

G

DNA-damage-inducible transcript 4

affects response to substance

DDIT4 protein affects the susceptibility to Mitoxantrone

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105

G

dehydrogenase/reductase 2

affects response to substance

DHRS2 protein affects the susceptibility to Mitoxantrone

NCBI chr15:32,658,855...32,673,591
Ensembl chr15:28,688,940...28,703,644

G

DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease

affects response to substance

DIS3 protein affects the susceptibility to Mitoxantrone

NCBI chr15:82,231,922...82,258,299
Ensembl chr15:75,823,436...75,850,642

G

dystrophin

decreases expression

Mitoxantrone results in decreased expression of DMD mRNA

PMID:26537877 PMID:28940058

NCBI chr X:51,070,098...53,437,845
Ensembl chr X:47,272,331...49,504,207

G

dual specificity phosphatase 4

affects response to substance
increases expression

DUSP4 protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in increased expression of DUSP4 mRNA

PMID:16217747 PMID:26537877 PMID:28940058

NCBI chr16:64,079,893...64,101,396
Ensembl chr16:57,377,229...57,398,138

G

dual specificity tyrosine phosphorylation regulated kinase 2

affects response to substance

DYRK2 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:56,235,276...56,265,741
Ensembl chr 7:54,349,610...54,380,106

G

early growth response 1

affects response to substance

EGR1 protein affects the susceptibility to Mitoxantrone

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2 subunit alpha

affects response to substance

EIF2S1 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 5A

affects response to substance

EIF5A protein affects the susceptibility to Mitoxantrone

NCBI chr10:55,138,821...55,143,272
Ensembl chr10:54,640,024...54,644,656

G

ELAV like RNA binding protein 4

affects response to substance

ELAVL4 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 5:130,285,418...130,429,106
Ensembl chr 5:125,056,848...125,200,446

G

ELOVL fatty acid elongase 5

affects response to substance

ELOVL5 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 8:87,671,164...87,737,618
Ensembl chr 8:78,790,846...78,857,284

G

engrailed homeobox 2

affects response to substance

EN2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:7,954,953...7,960,793
Ensembl chr 4:7,221,096...7,226,943

G

ectodermal-neural cortex 1

affects response to substance

ENC1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:28,550,464...28,562,713

G

erythrocyte membrane protein band 4.1-like 2

affects response to substance

EPB41L2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 1:21,682,336...21,857,106
Ensembl chr 1:19,863,009...20,037,721

G

erb-b2 receptor tyrosine kinase 2

multiple interactions
decreases response to substance

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 3

decreases expression

Mitoxantrone results in decreased expression of ERBB3 mRNA

PMID:26537877 PMID:28940058

NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:996,225...1,015,525

G

electron transfer flavoprotein dehydrogenase

decreases expression

Mitoxantrone results in decreased expression of ETFDH protein

NCBI chr 2:167,038,707...167,060,758
Ensembl chr 2:164,729,749...164,762,745

G

ecotropic viral integration site 5

affects response to substance

EVI5 protein affects the susceptibility to Mitoxantrone

NCBI chr14:2,020,524...2,166,593
Ensembl chr14:1,875,647...2,021,678

G

exostosin-like glycosyltransferase 2

affects response to substance

EXTL2 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:203,922,217...203,946,940
Ensembl chr 2:203,922,187...203,943,653

G

fatty acid binding protein 3

increases expression

Mitoxantrone results in increased expression of FABP3 protein

NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:142,651,956...142,658,718

G

family with sequence similarity 117, member A

affects response to substance

FAM117A protein affects the susceptibility to Mitoxantrone

NCBI chr10:80,778,229...80,822,119
Ensembl chr10:80,281,408...80,325,343

G

Fas cell surface death receptor

multiple interactions
increases expression

Hydrocortisone promotes the reaction [Mitoxantrone results in increased expression of FAS]
Mitoxantrone results in increased expression of FAS mRNA; Mitoxantrone results in increased expression of FAS protein

PMID:9676859 PMID:26537877 PMID:28940058

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

decreases response to substance
multiple interactions

FASN protein results in decreased susceptibility to Mitoxantrone
orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261

G

farnesyl diphosphate farnesyl transferase 1

affects response to substance

FDFT1 protein affects the susceptibility to Mitoxantrone

NCBI chr15:41,588,114...41,616,168
Ensembl chr15:37,412,146...37,440,287

G

four and a half LIM domains 1

increases expression

Mitoxantrone results in increased expression of FHL1 mRNA

NCBI chr X:139,592,794...139,652,290
Ensembl chr X:134,555,479...134,614,928

G

fibronectin leucine rich transmembrane protein 3

affects response to substance

FLRT3 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:148,448,115...148,461,458
Ensembl chr 3:127,994,226...128,007,841

G

fibronectin type III domain containing 3a

affects response to substance

FNDC3A protein affects the susceptibility to Mitoxantrone

NCBI chr15:54,099,510...54,276,963
Ensembl chr15:47,689,919...47,866,784

G

forkhead box F2

affects response to substance

FOXF2 protein affects the susceptibility to Mitoxantrone

NCBI chr17:33,044,446...33,051,259
Ensembl chr17:32,836,777...32,842,176

G

FYN proto-oncogene, Src family tyrosine kinase

affects response to substance

FYN protein affects the susceptibility to Mitoxantrone

NCBI chr20:44,322,635...44,514,498
Ensembl chr20:42,766,369...42,959,911

G

frizzled class receptor 2

affects response to substance

FZD2 protein affects the susceptibility to Mitoxantrone

NCBI chr10:88,061,988...88,063,898
Ensembl chr10:87,561,326...87,565,334

G

GTP cyclohydrolase 1

affects response to substance

GCH1 protein affects the susceptibility to Mitoxantrone

NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698

G

growth differentiation factor 15

increases expression

Mitoxantrone results in increased expression of GDF15 mRNA

PMID:26537877 PMID:28940058

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055

G

glutamate-ammonia ligase

affects response to substance

GLUL protein affects the susceptibility to Mitoxantrone

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:66,025,630...66,035,108

G

glutathione peroxidase 1

increases expression

Mitoxantrone results in increased expression of GPX1 mRNA

PMID:26537877 PMID:28940058

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 3

affects response to substance

GPX3 protein affects the susceptibility to Mitoxantrone

NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,028,570...39,037,035

G

guanylate cyclase 1 soluble subunit beta 1

affects response to substance

GUCY1B1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:167,348,825...167,398,916

G

H2A.X variant histone

increases expression
increases phosphorylation
multiple interactions

Mitoxantrone results in increased expression of H2AX protein
Mitoxantrone results in increased phosphorylation of H2AX protein
Poly(ADP-ribose) Polymerase Inhibitors affects the reaction [Mitoxantrone results in increased expression of H2AX protein]

PMID:19738048 PMID:24994473 PMID:29913208

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

decreases expression

Mitoxantrone results in decreased expression of HADHB protein

NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:26,153,578...26,184,869

G

histone deacetylase 4

affects response to substance

HDAC4 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:92,507,611...92,750,164

G

high mobility group 20 B

affects response to substance

HMG20B protein affects the susceptibility to Mitoxantrone

NCBI chr 7:8,368,934...8,373,650
Ensembl chr 7:8,368,990...8,373,640

G

homeo box A5

affects response to substance

HOXA5 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:82,632,958...82,636,851
Ensembl chr 4:81,302,353...81,306,234

G

histidine rich calcium binding protein

decreases expression

Mitoxantrone results in decreased expression of HRC mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:104,949,750...104,953,475
Ensembl chr 1:95,813,253...95,816,984

G

heat shock protein family A (Hsp70) member 2

affects response to substance

HSPA2 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:95,128,350...95,131,287

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

affects response to substance
decreases expression

IDH3A protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in decreased expression of IDH3A protein

PMID:16217747 PMID:34246718

NCBI chr 8:63,867,882...63,887,223
Ensembl chr 8:54,971,740...54,991,084

G

interferon induced transmembrane protein 1

affects response to substance

IFITM1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:205,496,757...205,498,796
Ensembl chr 1:196,067,963...196,069,169

G

insulin-like growth factor 1 receptor

affects response to substance

IGF1R protein affects the susceptibility to Mitoxantrone

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor 2 mRNA binding protein 3

affects response to substance

IGF2BP3 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:79,391,367...79,525,923
Ensembl chr 4:78,060,494...78,194,865

G

insulin-like growth factor binding protein 3

affects response to substance

IGFBP3 protein affects the susceptibility to Mitoxantrone

NCBI chr14:86,270,208...86,277,944
Ensembl chr14:82,056,347...82,064,083

G

insulin-like growth factor binding protein 7

affects response to substance

IGFBP7 protein affects the susceptibility to Mitoxantrone

NCBI chr14:31,091,681...31,151,623
Ensembl chr14:30,737,164...30,797,314

G

interleukin 13 receptor subunit alpha 2

affects response to substance

IL13RA2 protein affects the susceptibility to Mitoxantrone

NCBI chr X:115,814,620...115,886,080
Ensembl chr X:111,002,592...111,072,381

G

inner membrane mitochondrial protein

decreases expression

Mitoxantrone results in decreased expression of IMMT protein

NCBI chr 4:105,438,657...105,477,370
Ensembl chr 4:103,880,459...103,919,109

G

IQ motif containing GTPase activating protein 1

affects response to substance

IQGAP1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:144,088,788...144,178,989
Ensembl chr 1:134,679,586...134,769,755

G

interferon regulatory factor 7

affects response to substance

IRF7 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832

G

iroquois homeobox 1

affects response to substance

IRX1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 1:33,123,122...33,128,951
Ensembl chr 1:31,294,615...31,300,444

G

iroquois homeobox 4

decreases expression

Mitoxantrone results in decreased expression of IRX4 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:31,859,101...31,868,089
Ensembl chr 1:30,030,561...30,039,549

G

ISG15 ubiquitin-like modifier

affects response to substance

ISG15 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:166,784,148...166,785,435

G

interferon stimulated exonuclease gene 20

affects response to substance

ISG20 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:132,815,123...132,837,027

G

Janus kinase 2

decreases expression

Mitoxantrone results in decreased expression of JAK2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in increased expression of JUN mRNA]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily A regulatory beta subunit 2

affects response to substance

KCNAB2 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:168,182,228...168,270,760
Ensembl chr 5:162,901,896...162,988,243

G

potassium voltage-gated channel subfamily H member 2

decreases expression

Mitoxantrone results in decreased expression of KCNH2 mRNA

PMID:26537877 PMID:28940058

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

G

potassium inwardly-rectifying channel, subfamily J, member 2

increases expression

Mitoxantrone results in increased expression of KCNJ2 mRNA

PMID:26537877 PMID:28940058

NCBI chr10:96,560,225...96,570,788
Ensembl chr10:96,060,821...96,071,445

G

potassium voltage-gated channel subfamily Q member 1

decreases expression

Mitoxantrone results in decreased expression of KCNQ1 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:198,291,766...198,624,669

G

KRR1, small subunit processome component homolog

affects response to substance

KRR1 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:47,475,557...47,486,996
Ensembl chr 7:47,475,557...47,486,985

G

laminin subunit alpha 2

affects response to substance

LAMA2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 1:19,492,126...20,140,056
Ensembl chr 1:17,672,536...18,320,530

G

laminin subunit beta 1

affects response to substance

LAMB1 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:47,835,525...47,902,585

G

laminin subunit gamma 1

affects response to substance

LAMC1 protein affects the susceptibility to Mitoxantrone

NCBI chr13:67,924,872...68,051,986
Ensembl chr13:65,374,372...65,501,492

G

LBH regulator of WNT signaling pathway

affects response to substance

LBH protein affects the susceptibility to Mitoxantrone

NCBI chr 6:28,321,040...28,344,855
Ensembl chr 6:22,568,834...22,593,079

G

LIM domain binding 3

decreases expression

Mitoxantrone results in decreased expression of LDB3 mRNA

PMID:26537877 PMID:28940058

NCBI chr16:9,862,161...9,926,338
Ensembl chr16:9,855,927...9,918,532

G

LEM domain nuclear envelope protein 2

affects response to substance

LEMD2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr20:5,284,275...5,298,281
Ensembl chr20:5,282,397...5,296,626

G

leucine-rich repeat-containing G protein-coupled receptor 4

affects response to substance

LGR4 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:116,901,968...117,004,584
Ensembl chr 3:96,447,858...96,548,899

G

lipase A, lysosomal acid type

affects response to substance

LIPA protein affects the susceptibility to Mitoxantrone

NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:232,024,356...232,057,633

G

lipase G, endothelial type

affects response to substance

LIPG protein affects the susceptibility to Mitoxantrone

NCBI chr18:70,790,077...70,811,259
Ensembl chr18:68,514,923...68,536,260

G

LIM and cysteine-rich domains 1

increases expression

Mitoxantrone results in increased expression of LMCD1 mRNA

NCBI chr 4:146,948,993...147,007,878
Ensembl chr 4:145,393,145...145,452,046

G

lamin B1

multiple interactions

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein

NCBI chr18:52,373,939...52,413,284
Ensembl chr18:50,175,874...50,214,502

G

mono-ADP ribosylhydrolase 1

affects response to substance

MACROD1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:204,246,238...204,387,027
Ensembl chr 1:204,246,166...204,389,716

G

MAF bZIP transcription factor F

affects response to substance

MAFF mRNA affects the susceptibility to Mitoxantrone

NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:110,912,499...110,923,851

G

MAGE family member D1

affects response to substance

MAGED1 protein affects the susceptibility to Mitoxantrone

NCBI chr X:63,416,464...63,423,167
Ensembl chr X:59,422,717...59,429,364

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

Mitoxantrone results in decreased expression of and results in increased lipidation of MAP1LC3B protein

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

malate dehydrogenase 2

decreases expression

Mitoxantrone results in decreased expression of MDH2 protein

NCBI chr12:26,530,886...26,543,841
Ensembl chr12:20,894,262...20,907,271

G

MDM2 proto-oncogene

decreases response to substance

MDM2 promoter SNP results in decreased susceptibility to Mitoxantrone

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915

G

mesoderm specific transcript

affects response to substance

MEST protein affects the susceptibility to Mitoxantrone

NCBI chr 4:60,321,814...60,332,288
Ensembl chr 4:59,354,447...59,366,145

G

molybdenum cofactor sulfurase

affects response to substance

MOCOS protein affects the susceptibility to Mitoxantrone

NCBI chr18:16,206,402...16,251,928
Ensembl chr18:15,931,654...15,977,187

G

mitochondrial pyruvate carrier 2

affects response to substance

MPC2 protein affects the susceptibility to Mitoxantrone

NCBI chr13:80,261,143...80,280,668
Ensembl chr13:77,728,250...77,747,664

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

affects response to substance

MTHFD2 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:117,368,833...117,380,350
Ensembl chr 4:115,811,139...115,822,608

G

MAX interactor 1, dimerization protein

affects response to substance

MXI1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:262,329,274...262,389,037
Ensembl chr 1:252,323,303...252,383,681

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
multiple interactions

Mitoxantrone results in decreased expression of MYC mRNA
Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in decreased expression of MYC mRNA]

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

MYC binding protein 2

affects response to substance

MYCBP2 protein affects the susceptibility to Mitoxantrone

NCBI chr15:86,352,061...86,590,126
Ensembl chr15:79,937,354...80,175,498

G

myosin heavy chain 6

decreases expression

Mitoxantrone results in decreased expression of MYH6 mRNA

PMID:26537877 PMID:28940058

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:28,417,616...28,441,720

G

myosin heavy chain 7

decreases expression

Mitoxantrone results in decreased expression of MYH7 mRNA

PMID:26537877 PMID:28940058

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:28,446,550...28,468,217

G

myomesin 2

decreases expression

Mitoxantrone results in decreased expression of MYOM2 mRNA

PMID:26537877 PMID:28940058

NCBI chr16:81,222,467...81,295,025
Ensembl chr16:74,520,157...74,592,772

G

nicotinamide phosphoribosyltransferase

affects response to substance

NAMPT protein affects the susceptibility to Mitoxantrone

NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:49,424,332...49,462,100

G

NADH:ubiquinone oxidoreductase subunit S5

affects response to substance

NDUFS5 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:141,258,828...141,264,552
Ensembl chr 5:135,974,034...135,979,603
Ensembl chr14:135,974,034...135,979,603
Ensembl chr 2:135,974,034...135,979,603

G

neurofilament heavy chain

affects response to substance

NEFH protein affects the susceptibility to Mitoxantrone

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:79,830,362...79,840,351

G

nidogen 2

affects response to substance

NID2 protein affects the susceptibility to Mitoxantrone

NCBI chr15:4,507,224...4,562,949
Ensembl chr15:4,458,084...4,513,843

G

nuclear receptor subfamily 3, group C, member 1

decreases activity

Mitoxantrone results in decreased activity of NR3C1 protein

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 2

affects response to substance

NR4A2 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877

G

nebulin-related anchoring protein

decreases expression

Mitoxantrone results in decreased expression of NRAP mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:265,355,324...265,433,229
Ensembl chr 1:255,350,113...255,427,693

G

nuclear receptor interacting protein 1

affects response to substance

NRIP1 protein affects the susceptibility to Mitoxantrone

NCBI chr11:28,382,835...28,466,483
Ensembl chr11:14,895,553...14,981,761

G

3-oxoacid CoA transferase 1

affects response to substance

OXCT1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:54,963,964...55,112,303
Ensembl chr 2:53,236,368...53,384,714

G

prolyl 4-hydroxylase subunit alpha 1

affects response to substance

P4HA1 protein affects the susceptibility to Mitoxantrone

NCBI chr20:27,784,696...27,895,785
Ensembl chr20:27,302,141...27,352,786

G

parkin coregulated like

affects response to substance

PACRGL mRNA affects the susceptibility to Mitoxantrone

NCBI chr14:62,532,019...62,556,977
Ensembl chr14:62,532,030...62,556,993

G

poly (ADP-ribose) polymerase 1

multiple interactions

[Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]

PMID:8840993 PMID:15582267

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

PBX homeobox 1

affects response to substance

PBX1 protein affects the susceptibility to Mitoxantrone

NCBI chr13:82,811,664...83,121,447
Ensembl chr13:80,278,770...80,588,594

G

phosphodiesterase 4D

affects response to substance

PDE4D protein affects the susceptibility to Mitoxantrone

NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:40,019,933...41,525,884

G

phosphodiesterase 8A

affects response to substance

PDE8A protein affects the susceptibility to Mitoxantrone

NCBI chr 1:144,575,203...144,698,216
Ensembl chr 1:135,166,237...135,288,024

G

pyruvate dehydrogenase E1 subunit alpha 1

decreases expression

Mitoxantrone results in decreased expression of PDHA1 protein

NCBI chr X:38,509,158...38,522,986
Ensembl chr X:34,700,409...34,714,311

G

prohibitin 2

decreases expression

Mitoxantrone results in decreased expression of PHB2 protein

NCBI chr 4:159,203,948...159,208,561
Ensembl chr 4:157,517,577...157,522,272

G

phosphoglycerate dehydrogenase

affects response to substance

PHGDH protein affects the susceptibility to Mitoxantrone

NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:185,906,966...185,935,944

G

PLAG1 like zinc finger 1

affects response to substance

PLAGL1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:9,297,066...9,337,394
Ensembl chr 1:7,477,177...7,517,228

G

plasminogen activator, tissue type

affects response to substance

PLAT protein affects the susceptibility to Mitoxantrone

NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223

G

phospholipase C, beta 4

affects response to substance

PLCB4 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:143,405,721...143,775,129
Ensembl chr 3:122,953,196...123,322,392

G

pyridoxal phosphate binding protein

affects response to substance

PLPBP protein affects the susceptibility to Mitoxantrone

NCBI chr16:71,705,064...71,717,726
Ensembl chr16:65,002,223...65,014,886

G

PML nuclear body scaffold

affects mutagenesis

Mitoxantrone affects the mutagenesis of PML gene

NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:58,628,837...58,658,971

G

protein phosphatase 1, regulatory (inhibitor) subunit 2

affects response to substance

PPP1R2 protein affects the susceptibility to Mitoxantrone

NCBI chr11:82,977,634...82,999,426
Ensembl chr11:69,472,555...69,494,463

G

protein phosphatase 1, regulatory subunit 3A

decreases expression

Mitoxantrone results in decreased expression of PPP1R3A mRNA

PMID:26537877 PMID:28940058

NCBI chr 4:43,905,648...43,946,236
Ensembl chr 4:42,939,599...42,980,638

G

PR/SET domain 16

decreases expression

Mitoxantrone results in decreased expression of PRDM16 mRNA

PMID:26537877 PMID:28940058

NCBI chr 5:170,162,275...170,486,371
Ensembl chr 5:164,880,587...165,203,601

G

peroxiredoxin 2

affects response to substance

PRDX2 protein affects the susceptibility to Mitoxantrone

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:23,180,930...23,186,194

G

PRELI domain containing 3B

affects response to substance

PRELID3B protein affects the susceptibility to Mitoxantrone

NCBI chr 3:183,681,257...183,689,253
Ensembl chr 3:163,262,985...163,271,181

G

protein kinase cAMP-dependent X-linked catalytic subunit

increases expression

Mitoxantrone results in increased expression of PRKX mRNA

PMID:26537877 PMID:28940058

NCBI chr X:45,701,747...45,745,210
Ensembl chr X:41,823,355...41,866,669

G

protein tyrosine phosphatase, receptor type, E

affects response to substance

PTPRE protein affects the susceptibility to Mitoxantrone

NCBI chr 1:199,774,195...199,924,646
Ensembl chr 1:190,344,401...190,489,534

G

glycogen phosphorylase, muscle associated

decreases expression

Mitoxantrone results in decreased expression of PYGM mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:213,119,805...213,134,622
Ensembl chr 1:203,690,533...203,705,368

G

retinoic acid receptor, alpha

affects mutagenesis

Mitoxantrone affects the mutagenesis of RARA gene

NCBI chr10:84,379,780...84,424,371
Ensembl chr10:83,893,384...83,928,142

G

retinoic acid receptor, beta

increases expression

Mitoxantrone results in increased expression of RARB mRNA alternative form

NCBI chr15:10,837,252...11,482,037
Ensembl chr15:8,406,492...9,051,288

G

RAS p21 protein activator 1

affects response to substance

RASA1 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 2:17,593,136...17,676,707
Ensembl chr 2:15,857,980...15,940,854

G

RB binding protein 8, endonuclease

affects response to substance

RBBP8 protein affects the susceptibility to Mitoxantrone

NCBI chr18:3,198,188...3,263,643
Ensembl chr18:2,921,286...2,988,846

G

RNA binding motif protein 17

multiple interactions
decreases response to substance

LY 117018 inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]; Tamoxifen inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]

NCBI chr17:71,846,941...71,863,834
Ensembl chr17:66,937,140...66,954,014

G

RCC1 and BTB domain containing protein 1

affects response to substance

RCBTB1 protein affects the susceptibility to Mitoxantrone

NCBI chr15:37,430,453...37,477,920
Ensembl chr15:33,319,586...33,365,302

G

ring finger and CHY zinc finger domain containing 1

affects response to substance

RCHY1 protein affects the susceptibility to Mitoxantrone

NCBI chr14:16,397,533...16,413,286
Ensembl chr14:16,113,224...16,129,167

G

regulator of G-protein signaling 2

affects response to substance

RGS2 protein affects the susceptibility to Mitoxantrone

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:55,798,829...55,802,385

G

Rho family GTPase 1

increases expression

Mitoxantrone results in increased expression of RND1 mRNA

NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:129,821,311...129,828,399

G

Ras-related GTP binding D

affects response to substance

RRAGD mRNA affects the susceptibility to Mitoxantrone

NCBI chr 5:52,170,234...52,205,700
Ensembl chr 5:47,373,463...47,409,356

G

RUNX family transcription factor 3

affects response to substance

RUNX3 protein affects the susceptibility to Mitoxantrone

NCBI chr 5:152,644,270...152,702,835
Ensembl chr 5:147,360,994...147,419,156

G

ryanodine receptor 2

decreases expression

Mitoxantrone results in decreased expression of RYR2 mRNA

PMID:26537877 PMID:28940058

NCBI chr17:63,081,527...63,667,141
Ensembl chr17:58,389,925...58,975,142

G

spalt-like transcription factor 2

affects response to substance

SALL2 protein affects the susceptibility to Mitoxantrone

NCBI chr15:27,494,831...27,512,402
Ensembl chr15:25,021,345...25,038,918

G

SATB homeobox 2

affects response to substance

SATB2 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:65,842,351...66,028,569
Ensembl chr 9:58,350,246...58,530,707

G

stearoyl-CoA desaturase

affects response to substance

SCD protein affects the susceptibility to Mitoxantrone

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562

G

schwannomin interacting protein 1

affects response to substance

SCHIP1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:154,437,217...155,198,560
Ensembl chr 2:152,126,953...152,888,585

G

sodium voltage-gated channel beta subunit 2

decreases expression

Mitoxantrone results in decreased expression of SCN2B mRNA

PMID:26537877 PMID:28940058

NCBI chr 8:54,322,383...54,334,519
Ensembl chr 8:45,425,629...45,437,765

G

sodium voltage-gated channel alpha subunit 5

decreases expression

Mitoxantrone results in decreased expression of SCN5A mRNA

PMID:26537877 PMID:28940058

NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:119,220,905...119,318,769

G

syndecan 2

affects response to substance

SDC2 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:64,127,110...64,241,081

G

SEC31 homolog A, COPII coat complex component

affects response to substance

SEC31A protein affects the susceptibility to Mitoxantrone

NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273

G

serpin family E member 1

increases expression

Mitoxantrone results in increased expression of SERPINE1 mRNA

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657

G

stratifin

affects response to substance

SFN protein affects the susceptibility to Mitoxantrone

NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:145,826,201...145,831,314

G

secreted frizzled-related protein 4

affects response to substance

SFRP4 mRNA affects the susceptibility to Mitoxantrone

NCBI chr17:49,974,532...50,026,448
Ensembl chr17:45,234,097...45,330,736

G

solute carrier family 16, member 6

affects response to substance

SLC16A6 protein affects the susceptibility to Mitoxantrone

NCBI chr10:94,923,888...94,946,990
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 25 member 11

decreases expression

Mitoxantrone results in decreased expression of SLC25A11 protein

NCBI chr10:55,856,209...55,859,060
Ensembl chr10:55,357,597...55,360,410

G

solute carrier family 7 member 5

affects response to substance

SLC7A5 protein affects the susceptibility to Mitoxantrone

NCBI chr19:66,843,808...66,872,412
Ensembl chr19:49,935,220...49,963,823

G

solute carrier organic anion transporter family, member 4a1

affects response to substance

SLCO4A1 protein affects the susceptibility to Mitoxantrone

NCBI chr 3:187,936,735...187,955,873
Ensembl chr 3:167,559,316...167,578,305

G

SMAD family member 2

affects response to substance

SMAD2 protein affects the susceptibility to Mitoxantrone

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323

G

sorbin and SH3 domain containing 1

affects response to substance

SORBS1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:249,057,324...249,279,703
Ensembl chr 1:239,108,777...239,330,169

G

spondin 1

affects response to substance

SPON1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:177,363,526...177,662,689
Ensembl chr 1:167,928,972...168,228,226

G

spondin 2

affects response to substance

SPON2 protein affects the susceptibility to Mitoxantrone

NCBI chr14:81,713,070...81,742,510
Ensembl chr14:77,511,901...77,517,996

G

secreted phosphoprotein 1

increases expression

Mitoxantrone results in increased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162

G

sequestosome 1

affects expression
decreases expression

Mitoxantrone affects the expression of SQSTM1 protein
Mitoxantrone metabolite results in decreased expression of SQSTM1 protein

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673

G

steroid 5 alpha-reductase 1

affects response to substance

SRD5A1 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:33,686,391...33,720,461

G

succinate-CoA ligase ADP-forming subunit beta

decreases expression

Mitoxantrone results in decreased expression of SUCLA2 protein

NCBI chr15:55,161,894...55,215,031
Ensembl chr15:48,752,312...48,805,138

G

synaptotagmin-like 2

affects response to substance

SYTL2 mRNA affects the susceptibility to Mitoxantrone

NCBI chr 1:153,685,403...153,791,758
Ensembl chr 1:144,273,360...144,379,222

G

transgelin

affects response to substance

TAGLN protein affects the susceptibility to Mitoxantrone

NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:46,222,472...46,230,668

G

transporter 1, ATP binding cassette subfamily B member

affects response to substance

TAP1 protein affects the susceptibility to Mitoxantrone

NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,656,263...4,666,901

G

TBC1 domain family, member 8

affects response to substance

TBC1D8 protein affects the susceptibility to Mitoxantrone

NCBI chr 9:41,651,394...41,761,432
Ensembl chr 9:41,651,395...41,761,409

G

trefoil factor 3

affects response to substance

TFF3 protein affects the susceptibility to Mitoxantrone

NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,193,262...9,198,054

G

transforming growth factor, beta 2

increases expression

Mitoxantrone results in increased expression of TGFB2 mRNA

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405

G

TIA1 cytotoxic granule-associated RNA binding protein

affects response to substance

TIA1 protein affects the susceptibility to Mitoxantrone

NCBI chr 4:120,410,180...120,440,676
Ensembl chr 4:118,852,837...118,880,586

G

TIMP metallopeptidase inhibitor 1

increases expression

Mitoxantrone results in increased expression of TIMP1 mRNA

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664

G

transmembrane protein 47

affects response to substance

TMEM47 protein affects the susceptibility to Mitoxantrone

NCBI chr X:49,338,532...49,365,026
Ensembl chr X:45,421,405...45,447,900

G

tankyrase

affects response to substance

TNKS protein affects the susceptibility to Mitoxantrone

NCBI chr16:63,922,969...64,073,972
Ensembl chr16:57,225,094...57,366,260

G

troponin T1, slow skeletal type

decreases expression

Mitoxantrone results in decreased expression of TNNT1 mRNA

PMID:26537877 PMID:28940058

NCBI chr 1:78,349,035...78,359,394
Ensembl chr 1:69,306,362...69,316,721

G

tumor protein p53

affects activity

Mitoxantrone affects the activity of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

tumor protein D52

affects response to substance

TPD52 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:94,642,514...94,723,442
Ensembl chr 2:92,735,620...92,816,622

G

tropomyosin 1

affects response to substance

TPM1 protein affects the susceptibility to Mitoxantrone

NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:67,635,479...67,662,802

G

tribbles pseudokinase 1

affects response to substance

TRIB1 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:93,096,001...93,102,547
Ensembl chr 7:91,206,579...91,214,731

G

tripartite motif-containing 2

affects response to substance

TRIM2 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:171,798,654...171,950,193
Ensembl chr 2:169,500,634...169,652,927

G

ubiquitin-like 3

affects response to substance

UBL3 protein affects the susceptibility to Mitoxantrone

NCBI chr12:6,473,684...6,518,331
Ensembl chr12:6,473,460...6,518,862

G

ubiquitin C-terminal hydrolase L1

affects response to substance

UCHL1 protein affects the susceptibility to Mitoxantrone

NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,485,031...41,495,590

G

ubiquinol-cytochrome c reductase hinge protein

affects response to substance

UQCRH protein affects the susceptibility to Mitoxantrone

NCBI chr 5:134,782,687...134,790,882
Ensembl chr 5:129,545,984...129,554,242

G

utrophin

affects response to substance

UTRN protein affects the susceptibility to Mitoxantrone

NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:6,722,594...7,224,313

G

versican

affects response to substance

VCAN protein affects the susceptibility to Mitoxantrone

NCBI chr 2:22,497,035...22,595,955
Ensembl chr 2:20,761,718...20,860,637

G

voltage-dependent anion channel 1

decreases expression

Mitoxantrone results in decreased expression of VDAC1 protein

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:36,532,244...36,559,640

G

tryptophanyl-tRNA synthetase 1

affects response to substance

WARS1 protein affects the susceptibility to Mitoxantrone

NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:127,776,090...127,807,269

G

WASH complex subunit 3

affects response to substance

WASHC3 protein affects the susceptibility to Mitoxantrone

NCBI chr 7:24,508,544...24,553,012
Ensembl chr 7:22,621,078...22,690,696

G

X-linked inhibitor of apoptosis

affects localization
decreases expression

Mitoxantrone affects the localization of XIAP protein
Mitoxantrone results in decreased expression of XIAP protein

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

increases expression

Mitoxantrone results in increased expression of YWHAE protein

NCBI chr10:61,082,934...61,120,618
Ensembl chr10:60,584,652...60,671,589

G

zinc finger AN1-type containing 1

affects response to substance

ZFAND1 protein affects the susceptibility to Mitoxantrone

NCBI chr 2:93,351,918...93,364,959
Ensembl chr 2:91,444,508...91,453,246

G

zinc finger, matrin type 3

increases expression

Mitoxantrone results in increased expression of ZMAT3 mRNA

PMID:26537877 PMID:28940058

NCBI chr 2:117,034,517...117,066,141
Ensembl chr 2:115,106,966...115,136,863

G

zinc finger and SCAN domain containing 18

affects response to substance

ZSCAN18 protein affects the susceptibility to Mitoxantrone

NCBI chr 1:73,332,883...73,349,846
Ensembl chr 1:73,332,889...73,345,897

Morindone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

morindone results in increased expression of BAX mRNA
[TP53 protein mutant form affects the susceptibility to morindone] which affects the expression of BAX mRNA

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

B-Raf proto-oncogene, serine/threonine kinase

multiple interactions
decreases expression

[KRAS protein mutant form affects the susceptibility to morindone] which affects the expression of BRAF protein
morindone results in decreased expression of BRAF mRNA; morindone results in decreased expression of BRAF protein

NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463

G

cyclin-dependent kinase inhibitor 1A

decreases expression

morindone results in decreased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

KRAS proto-oncogene, GTPase

multiple interactions
affects response to substance
increases expression
decreases expression

[KRAS protein mutant form affects the susceptibility to morindone] which affects the expression of BRAF protein; [KRAS protein mutant form affects the susceptibility to morindone] which affects the expression of PIK3CA protein mutant form
morindone results in increased expression of KRAS protein mutant form
morindone results in decreased expression of KRAS mRNA mutant form

NCBI chr 4:179,916,255...179,949,613

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

multiple interactions
increases expression
decreases expression

[KRAS protein mutant form affects the susceptibility to morindone] which affects the expression of PIK3CA protein mutant form
morindone results in increased expression of PIK3CA mRNA mutant form
morindone results in decreased expression of PIK3CA protein mutant form

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032

G

tumor protein p53

decreases expression
increases expression
multiple interactions
affects response to substance

morindone results in decreased expression of TP53 mRNA mutant form
morindone results in increased expression of TP53 protein mutant form
[TP53 protein mutant form affects the susceptibility to morindone] which affects the expression of BAX mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

Obtusifolin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 6

decreases activity

obtusifolin results in decreased activity of SLC22A6 protein

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

decreases activity

obtusifolin results in decreased activity of SLC22A8 protein

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450

physcion

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

increases expression

physcione results in increased expression of ABCB11 mRNA; physcione results in increased expression of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 4

decreases expression

physcione results in decreased expression of ABCB4 mRNA

NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 2

decreases expression

physcione results in decreased expression of ABCC2 mRNA; physcione results in decreased expression of ABCC2 protein

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

decreases expression

physcione results in decreased expression of ABCC3 mRNA; physcione results in decreased expression of ABCC3 protein

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595

G

BCL2 associated X, apoptosis regulator

increases expression
decreases expression

physcione results in increased expression of BAX protein
physcione results in decreased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

physcione results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:33438235

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression

physcione results in decreased expression of CYP27A1 mRNA

NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases hydroxylation

CYP2B6 protein results in increased hydroxylation of physcione

NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases hydroxylation

CYP2C19 protein results in increased hydroxylation of physcione

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases hydroxylation

CYP3A4 protein results in increased hydroxylation of physcione

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

physcione results in decreased expression of CYP8B1 mRNA; physcione results in decreased expression of CYP8B1 protein

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:121,557,062...121,580,166

G

solute carrier family 10 member 1

decreases expression

physcione results in decreased expression of SLC10A1 mRNA; physcione results in decreased expression of SLC10A1 protein

NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:100,613,045...100,626,670

G

sulfotransferase family 1A member 1

decreases activity

physcione results in decreased activity of SULT1A1 protein

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:181,272,023...181,275,562

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of physcione

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465

quinizarin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

1,4-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

albumin

affects binding

1,4-dihydroxyanthraquinone binds to ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

1,4-dihydroxyanthraquinone results in decreased activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

estrogen receptor 1

multiple interactions

1,4-dihydroxyanthraquinone binds to and results in increased activity of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465

Rhein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

Enzymes and Coenzymes inhibits the reaction [rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; rhein metabolite inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

actin alpha 2, smooth muscle

multiple interactions

rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

adhesion G protein-coupled receptor E1

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 protein]

NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,242,474...2,398,000

G

aryl hydrocarbon receptor

multiple interactions

rhein inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase

decreases activity

rhein results in decreased activity of ALKBH2 protein

NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914

G

BCL2 associated X, apoptosis regulator

increases expression

rhein results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

beclin 1

decreases expression

rhein results in decreased expression of BECN1 protein

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742

G

caspase 1

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased cleavage of CASP1 protein]

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

decreases expression

rhein results in decreased expression of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases cleavage

rhein results in increased cleavage of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

decreases expression

rhein results in decreased expression of CASP9 protein

Ensembl chr 5:154,109,046...154,126,626

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

rhein results in decreased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

rhein results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:33438235

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

rhein results in decreased activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

rhein results in decreased activity of CYP2D6 protein

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759

G

epidermal growth factor

decreases expression

rhein results in decreased expression of EGF protein

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064

G

erb-b2 receptor tyrosine kinase 2

decreases expression

rhein results in decreased expression of ERBB2 protein

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078

G

glutamic--pyruvic transaminase

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494

G

hypoxia inducible factor 1 subunit alpha

decreases expression
multiple interactions

rhein results in decreased expression of HIF1A protein
rhein inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

interferon gamma

increases expression
multiple interactions

rhein results in increased expression of IFNG protein
rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

multiple interactions

rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 17A

increases expression

rhein results in increased expression of IL17A protein

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL18 protein]

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

increases expression

rhein results in increased expression of IL2 protein

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

PMID:26784856 PMID:37023836

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit alpha 4

multiple interactions

rhein inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]; rhein inhibits the reaction [ITGA4 protein results in increased expression of TEK protein]; rhein inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]

NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:64,163,085...64,233,715

G

kinase insert domain receptor

multiple interactions

rhein inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018

G

midkine

multiple interactions

rhein inhibits the reaction [MDK protein results in increased phosphorylation of RELA protein]

NCBI chr 3:98,356,789...98,358,960
Ensembl chr 3:77,901,158...77,903,130

G

nuclear factor kappa B subunit 1

affects localization
decreases activity
multiple interactions

rhein affects the localization of NFKB1 protein
rhein results in decreased activity of NFKB1 protein
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NFKB1 mRNA]

PMID:21457705 PMID:37023836

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

NLR family, pyrin domain containing 3

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811

G

prostaglandin-endoperoxide synthase 2

decreases expression

rhein results in decreased expression of PTGS2 protein

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

decreases activity
multiple interactions
affects localization

rhein results in decreased activity of RELA protein
cobaltous chloride promotes the reaction [rhein affects the localization of RELA protein]
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of RELA protein]
rhein inhibits the reaction [MDK protein results in increased phosphorylation of RELA protein]

PMID:21457705 PMID:36731809 PMID:37023836

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 22 member 6

multiple interactions

rhein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

multiple interactions

rhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450

G

sequestosome 1

increases expression

rhein results in increased expression of SQSTM1 protein

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673

G

sulfotransferase family 1A member 1

decreases activity

rhein results in decreased activity of SULT1A1 protein

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:181,272,023...181,275,562

G

TEK receptor tyrosine kinase

multiple interactions

rhein inhibits the reaction [ITGA4 protein results in increased expression of TEK protein]

NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:109,607,077...109,733,804

G

transforming growth factor, beta 1

multiple interactions

rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

increases expression
multiple interactions

rhein results in increased expression of TNF protein
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; rhein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:26784856 PMID:31436023 PMID:37023836

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNFRSF1A-associated via death domain

increases expression

rhein results in increased expression of TRADD protein

NCBI chr19:50,046,057...50,048,158
Ensembl chr19:33,136,138...33,142,638

G

TNF receptor-associated factor 1

increases expression

rhein results in increased expression of TRAF1 protein

NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:18,222,054...18,241,807

G

vascular endothelial growth factor A

decreases expression
decreases response to substance
multiple interactions

rhein results in decreased expression of VEGFA protein
rhein results in decreased susceptibility to VEGFA protein
rhein inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]

PMID:21457705 PMID:36731809

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

rubiadin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcitonin receptor

decreases expression

rubiadin results in decreased expression of CALCR mRNA

NCBI chr 4:32,615,955...32,691,075
Ensembl chr 4:31,661,273...31,736,392

G

carbonic anhydrase 2

decreases expression

rubiadin results in decreased expression of CA2 mRNA

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:86,741,626...86,756,818

G

cathepsin K

increases activity

rubiadin results in increased activity of CTSK protein

NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:183,058,569...183,069,550

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

rubiadin results in decreased activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

rubiadin results in decreased activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

rubiadin results in decreased activity of CYP2D6 protein

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759

G

NFKB inhibitor alpha

multiple interactions

rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

G

TNF receptor superfamily member 11B

increases expression

rubiadin results in increased expression of TNFRSF11B mRNA; rubiadin results in increased expression of TNFRSF11B protein

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538

G

TNF superfamily member 11

decreases expression
multiple interactions

rubiadin results in decreased expression of TNFSF11 mRNA; rubiadin results in decreased expression of TNFSF11 protein
rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19909
chemical entity	19907
molecular entity	19906
polyatomic entity	19857
heteroatomic molecular entity	19813
hydroxides	19384
organic hydroxy compound	18998
phenols	18705
hydroxyanthraquinones	514
(+)-1,1'-bislunatin	0
(+)-1,3,6,8-Tetrahydroxy-2-[(1R)-1-hydro	0
(+/-)-aspergilol G	0
(+/-)-aspergilol H	0
(-)-2'R-1-hydroxyisorhodoptilometrin	0
(1'S)-1'-O-methyl-7-chloroaverantin	0
(1'S)-6,1'-O,O-dimethyl-7-bromoaverantin	0
(1'S)-6,1'-O,O-dimethyl-7-chloroaverantin	0
(1'S)-6-O-methyl-7-bromoaverantin	0
(1'S)-6-O-methyl-7-chloroaverantin	0
(1'S)-7-chloroaverantin	0
(1'S)-7-chloroaverantin-1'-butyl ether	0
(1R,3R.4S)-4-hydroxyaustrocortilutein	0
(1S,3R)-1,3,8-trihydroxy-6-methoxy-3-methyl-1,2,3,4-tetrahydro-9,10-anthraquinone	0
(1S,3R)-austrocortirubin	0
(1S,3S)-austrocortilutein 8-O-beta-D-gentiobioside	0
(1S,3S)-austrocortirubin 8-O-beta-D-gentiobioside	0
(2R,3S)-7-ethyl-1,2,3,4-tetrahydro-2,3,8-trihydroxy-6-methoxy-3-methyl-9,10-anthracenedione	0
(3S,4aS,12bS)-3,4a,8,12b-tetrahydroxy-3-methyl-2,4,5,6-tetrahydrobenzo[a]anthracene-1,7,12-trione	0
(4R,8S)-10,16,18-trihydroxy-3,5-dioxapentacyclo[10.8.0.02,9.04,8.014,19]icosa-1,9,11,14(19),15,17-hexaene-13,20-dione	0
(5R,6R)-3-ethyl-1,5,6-trihydroxy-8-methoxy-5,6-dihydrobenzo[a]anthracene-7,12-dione	0
(S)-2,5-dihydroxy-2-methyl-1,2,3,4-tetrahydroanthracene-9,10-dione	0
1'-hydroxy-2'-ketoisorhodoptilometrin	0
1'-hydroxyisorhodoptilometrin	0
1'-hydroxyversicolorin B	0
1,2,6,8-Tetrahydroxy-3-methylanthraquinone 2-O-b-D-glucoside	0
1,3,5,8-Tetrahydroxy-6-methoxy-2-methylanthraquinone	0
1,3,5-Trihydroxy-6,7-dimethoxy-2-methylanthraquinone	0
1,3,6,7-8-Pentahydroxy-2-methoxyethylant	0
1,3,6,8-Tetrahydroxy-2-methoxyethylanthr	0
1,3,8-Trihydroxy-6-methoxyanthraquinone	0
1,3-Dihydroxy-6-hydroxymethyl-7-methoxyanthraquinone	0
1,3-dihydroxy-2,8-dimethoxy-6-methylanthraquinone	0
1,4,6-trihydroxy-8-(2′-oxohexyl)-9,10-anthraquinone	0
1,4,6-trihydroxy-8-(2′-oxopentyl)-9,10-anthraquinone	0
1,4,6-trihydroxy-8-butyl-9,10-anthraquinone	0
1,4,6-trihydroxy-8-hexyl-9,10-anthraquinone	0
1,4,6-trihydroxy-8-isopentyl-9,10-anthraquinone	0
1,4,6-trihydroxy-8-pentacarboxyl-9,10-anthraquinone	0
1,4,6-trihydroxy-8-pentyl-9,10-anthraquinone	0
1,4,6-trihydroxy-8-propyl-9,10-anthraquinone	0
1,7-dihydroxy-3-hydroxymethyl-9,10-anthraquinone	0
1-deoxyaustrocortirubin	0
2'-acetoxy-7-chlorocitreorosein	0
2,4,4',5,5'-Pentahydroxy-7,7'-dimethyl-2'-[(3,4,5-trihydroxyoxan-2-yl)oxy]-9H,9'H,10H,10'H-[1,1'-bianthracene]-9,9',10,10'-tetrone	0
2-O-acetylaltersolanol B	0
3,8-dihydroxy-1-propylanthraquinone	0
3-demethyl-3-(2-hydroxypropyl)-skyrin	0
4-dehydroxyaltersolanol A	0
5'-epi-averufanin	0
5-Chloro-6,8-dihydroxy-1-methoxy-3-methyanthraquinone	0
5-Chloro-w-hydroxyemodin	0
5-Chloroemodin	0
5-acetyl-2-methoxy-1,4,6-trihydroxy-anthraquinone	0
5-chloro-omega-hydroxy-1-O-methylemodin	0
6,1′-O,O-dimethylaverantin	0
6,6'-oxybis(1,3,8-trihydroxy-2-((S)-1-hydroxyhexyl)anthracene-9,10-dione)	0
6,6'-oxybis(1,3,8-trihydroxy-2-((S)-1-methoxyhexyl)anthracene-9,10-dione)	0
6,8,1'-tri-o-methylaverantin	0
6,8-Dihydroxy-1-methoxy-3-methylanthraquinone	0
6,8-O-dimethylbipolarin	0
6-O-methyl-7-chloroaverythrin	0
6-deoxy-13-hydroxy-8,11-dionedihydrogranaticin A	0
7-Chloro-1-O-methyl-w-hydroxyemodin	0
7-Chloro-6,8-dihydroxy-1-meth-oxy-3-methylanthraquinone	0
7-acetyl-1,3,6-trihydroxyanthracene-9,10-dione	0
7-chloroaverythrin	0
7-oxo-SD8	0
8-O-methylaverufin	0
8-O-methylnidurufin	0
9'-hydroxyaloesaponarin II	0
AQ-256	0
AQ-270a	0
Acetylalterporriol E	0
Acetylquestinol	0
Alterporriol C	0
Alterporriol F	0
Alterporriol L	0
Alterporriol M	0
Alterporriol N	0
Alterporriol P	0
Alterporriol Q	0
Alterporriol R	0
Alterporriol T	0
Alterporriol U	0
Alterporriol V	0
Alterporriol W	0
Alterporriol X	0
Alterporriol Z1	0
Alterporriol Z2	0
Alterporriol Z3	0
Altersolanol B	0
Altersolanol D	0
Altersolanol E	0
Altersolanol F	0
Altersolanol G	0
Altersolanol H	0
Altersolanol N	0
Altersolanol O	0
Altersolanol P	0
Amicenomycin A	0
Angumycinone A	0
Angumycinone B	0
Ansaseomycin A	0
Ansaseomycin B	0
Asparasone A	0
Aspergilol A	0
Aspergilol B	0
Aspergilol I	0
Aspetritone B	0
Aturanoside A	0
Aturanoside B	0
Austrocortilutein	0
Austrocortirubin	0
Auxarthrol B	0
Auxarthrol C	0
Auxarthrol D	0
Auxarthrol G	0
Averythrin	0
Basidifferquinone	0
Bostrycin	0
Cajaquinone	0
Capoamycin	1
Chrysolandol	0
Coccoquinone A	0
Coccoquinone B	0
Cytoskyrin B	0
Desmethyl dermoquinone	0
Diaporthemin B	0
Dihydroaltersolanol B	0
Dihydroaltersolanol C	0
Emodacidamide A	0
Emodacidamide B	0
Emodacidamide C	0
Emodacidamide D	0
Emodacidamide E	0
Emodacidamide F	0
Emodacidamide G	0
Emodacidamide H	0
Emodin 8-beta-D-glucoside	0
Ent-gephyromycin A	0
Evariquinone	0
Fusarnaphthoquinone C	0
Galvaquinone C	0
Gaudimycin A	0
Gaudimycin B	0
Gephyromycin	0
Haematommone	0
Heliocide B2	0
Heliocide H1	0
Heliocide H2	0
Heliocide H3	0
Heliocide H4	0
Isoversicolorin C	0
Julichrome Q1.6	0
Karimunone A	0
Lactoquinomycin E	0
Lupinacidin A	0
Lupinacidin B	0
Lupinacidin D	0
Macrosporin	1
Monacyclinone K	0
Morakotin A	0
Morakotin C	0
Morakotin D	0
Morakotin E	0
Neoanthraquinone	0
Neomacrophorin X	0
Nidurufin	0
Nidurufin-2'-(4-O-methyl)-beta-D-glucopyranose	0
Nigrosporin B	0
Nigrosporone B	0
Ochracenomicin C	0
Oxyskyrin	0
Paeciloquinone A	0
Paeciloquinone B	0
Paeciloquinone C	0
Paeciloquinone D	0
Paeciloquinone E	0
Paeciloquinone F	0
Paradictyoarthrin B	0
Penicillanthranin A	0
Penicillanthranin B	0
Penipurdin A	0
Phaseolorin I	0
Phomarin	0
Quinofuracin A	0
Quinofuracin B	0
Quinofuracin C	0
Quinofuracin D	0
Rhababerone	0
Rhodoislandin B	0
Saccharosporone A	0
Saccharosporone B	0
Stemphylanthranol A	0
Stemphylanthranol B	0
Termstrin A	0
Termstrin B	0
Torrubiellin B	0
UCT1072M1	0
UCT1072M2	0
Urdamycin X	0
Ustilanthracin A	0
Ustilanthracin B	0
Versicol	0
Versiconol B	0
WS 009 B	0
WS009 A	0
alterporriol E	0
dihydroxyanthraquinone +	354
hexahydroxyanthraquinone +	0
monohydroxyanthraquinone +	1
omega-acetylcarviolin	0
pentahydroxyanthraquinone +	0
robustaquinone A	0
tetrahydroxyanthraquinone +	0
trihydroxyanthraquinone +	239
Path 2
Term	Annotations
CHEBI ontology	19909
subatomic particle	19907
composite particle	19907
hadron	19907
baryon	19907
nucleon	19907
atomic nucleus	19907
atom	19907
main group element atom	19846
p-block element atom	19846
carbon group element atom	19784
carbon atom	19781
organic molecular entity	19781
heteroorganic entity	19540
organochalcogen compound	19301
organooxygen compound	19216
carbonyl compound	18947
ketone	17281
cyclic ketone	15929
quinone	9916
acenoquinone	7750
anthraquinone	526
hydroxyanthraquinones	514
(+)-1,1'-bislunatin	0
(+)-1,3,6,8-Tetrahydroxy-2-[(1R)-1-hydro	0
(+/-)-aspergilol G	0
(+/-)-aspergilol H	0
(-)-2'R-1-hydroxyisorhodoptilometrin	0
(1'S)-1'-O-methyl-7-chloroaverantin	0
(1'S)-6,1'-O,O-dimethyl-7-bromoaverantin	0
(1'S)-6,1'-O,O-dimethyl-7-chloroaverantin	0
(1'S)-6-O-methyl-7-bromoaverantin	0
(1'S)-6-O-methyl-7-chloroaverantin	0
(1'S)-7-chloroaverantin	0
(1'S)-7-chloroaverantin-1'-butyl ether	0
(1R,3R.4S)-4-hydroxyaustrocortilutein	0
(1S,3R)-1,3,8-trihydroxy-6-methoxy-3-methyl-1,2,3,4-tetrahydro-9,10-anthraquinone	0
(1S,3R)-austrocortirubin	0
(1S,3S)-austrocortilutein 8-O-beta-D-gentiobioside	0
(1S,3S)-austrocortirubin 8-O-beta-D-gentiobioside	0
(2R,3S)-7-ethyl-1,2,3,4-tetrahydro-2,3,8-trihydroxy-6-methoxy-3-methyl-9,10-anthracenedione	0
(3S,4aS,12bS)-3,4a,8,12b-tetrahydroxy-3-methyl-2,4,5,6-tetrahydrobenzo[a]anthracene-1,7,12-trione	0
(4R,8S)-10,16,18-trihydroxy-3,5-dioxapentacyclo[10.8.0.02,9.04,8.014,19]icosa-1,9,11,14(19),15,17-hexaene-13,20-dione	0
(5R,6R)-3-ethyl-1,5,6-trihydroxy-8-methoxy-5,6-dihydrobenzo[a]anthracene-7,12-dione	0
(S)-2,5-dihydroxy-2-methyl-1,2,3,4-tetrahydroanthracene-9,10-dione	0
1'-hydroxy-2'-ketoisorhodoptilometrin	0
1'-hydroxyisorhodoptilometrin	0
1'-hydroxyversicolorin B	0
1,2,6,8-Tetrahydroxy-3-methylanthraquinone 2-O-b-D-glucoside	0
1,3,5,8-Tetrahydroxy-6-methoxy-2-methylanthraquinone	0
1,3,5-Trihydroxy-6,7-dimethoxy-2-methylanthraquinone	0
1,3,6,7-8-Pentahydroxy-2-methoxyethylant	0
1,3,6,8-Tetrahydroxy-2-methoxyethylanthr	0
1,3,8-Trihydroxy-6-methoxyanthraquinone	0
1,3-Dihydroxy-6-hydroxymethyl-7-methoxyanthraquinone	0
1,3-dihydroxy-2,8-dimethoxy-6-methylanthraquinone	0
1,4,6-trihydroxy-8-(2′-oxohexyl)-9,10-anthraquinone	0
1,4,6-trihydroxy-8-(2′-oxopentyl)-9,10-anthraquinone	0
1,4,6-trihydroxy-8-butyl-9,10-anthraquinone	0
1,4,6-trihydroxy-8-hexyl-9,10-anthraquinone	0
1,4,6-trihydroxy-8-isopentyl-9,10-anthraquinone	0
1,4,6-trihydroxy-8-pentacarboxyl-9,10-anthraquinone	0
1,4,6-trihydroxy-8-pentyl-9,10-anthraquinone	0
1,4,6-trihydroxy-8-propyl-9,10-anthraquinone	0
1,7-dihydroxy-3-hydroxymethyl-9,10-anthraquinone	0
1-deoxyaustrocortirubin	0
2'-acetoxy-7-chlorocitreorosein	0
2,4,4',5,5'-Pentahydroxy-7,7'-dimethyl-2'-[(3,4,5-trihydroxyoxan-2-yl)oxy]-9H,9'H,10H,10'H-[1,1'-bianthracene]-9,9',10,10'-tetrone	0
2-O-acetylaltersolanol B	0
3,8-dihydroxy-1-propylanthraquinone	0
3-demethyl-3-(2-hydroxypropyl)-skyrin	0
4-dehydroxyaltersolanol A	0
5'-epi-averufanin	0
5-Chloro-6,8-dihydroxy-1-methoxy-3-methyanthraquinone	0
5-Chloro-w-hydroxyemodin	0
5-Chloroemodin	0
5-acetyl-2-methoxy-1,4,6-trihydroxy-anthraquinone	0
5-chloro-omega-hydroxy-1-O-methylemodin	0
6,1′-O,O-dimethylaverantin	0
6,6'-oxybis(1,3,8-trihydroxy-2-((S)-1-hydroxyhexyl)anthracene-9,10-dione)	0
6,6'-oxybis(1,3,8-trihydroxy-2-((S)-1-methoxyhexyl)anthracene-9,10-dione)	0
6,8,1'-tri-o-methylaverantin	0
6,8-Dihydroxy-1-methoxy-3-methylanthraquinone	0
6,8-O-dimethylbipolarin	0
6-O-methyl-7-chloroaverythrin	0
6-deoxy-13-hydroxy-8,11-dionedihydrogranaticin A	0
7-Chloro-1-O-methyl-w-hydroxyemodin	0
7-Chloro-6,8-dihydroxy-1-meth-oxy-3-methylanthraquinone	0
7-acetyl-1,3,6-trihydroxyanthracene-9,10-dione	0
7-chloroaverythrin	0
7-oxo-SD8	0
8-O-methylaverufin	0
8-O-methylnidurufin	0
9'-hydroxyaloesaponarin II	0
AQ-256	0
AQ-270a	0
Acetylalterporriol E	0
Acetylquestinol	0
Alterporriol C	0
Alterporriol F	0
Alterporriol L	0
Alterporriol M	0
Alterporriol N	0
Alterporriol P	0
Alterporriol Q	0
Alterporriol R	0
Alterporriol T	0
Alterporriol U	0
Alterporriol V	0
Alterporriol W	0
Alterporriol X	0
Alterporriol Z1	0
Alterporriol Z2	0
Alterporriol Z3	0
Altersolanol B	0
Altersolanol D	0
Altersolanol E	0
Altersolanol F	0
Altersolanol G	0
Altersolanol H	0
Altersolanol N	0
Altersolanol O	0
Altersolanol P	0
Amicenomycin A	0
Angumycinone A	0
Angumycinone B	0
Ansaseomycin A	0
Ansaseomycin B	0
Asparasone A	0
Aspergilol A	0
Aspergilol B	0
Aspergilol I	0
Aspetritone B	0
Aturanoside A	0
Aturanoside B	0
Austrocortilutein	0
Austrocortirubin	0
Auxarthrol B	0
Auxarthrol C	0
Auxarthrol D	0
Auxarthrol G	0
Averythrin	0
Basidifferquinone	0
Bostrycin	0
Cajaquinone	0
Capoamycin	1
Chrysolandol	0
Coccoquinone A	0
Coccoquinone B	0
Cytoskyrin B	0
Desmethyl dermoquinone	0
Diaporthemin B	0
Dihydroaltersolanol B	0
Dihydroaltersolanol C	0
Emodacidamide A	0
Emodacidamide B	0
Emodacidamide C	0
Emodacidamide D	0
Emodacidamide E	0
Emodacidamide F	0
Emodacidamide G	0
Emodacidamide H	0
Emodin 8-beta-D-glucoside	0
Ent-gephyromycin A	0
Evariquinone	0
Fusarnaphthoquinone C	0
Galvaquinone C	0
Gaudimycin A	0
Gaudimycin B	0
Gephyromycin	0
Haematommone	0
Heliocide B2	0
Heliocide H1	0
Heliocide H2	0
Heliocide H3	0
Heliocide H4	0
Isoversicolorin C	0
Julichrome Q1.6	0
Karimunone A	0
Lactoquinomycin E	0
Lupinacidin A	0
Lupinacidin B	0
Lupinacidin D	0
Macrosporin	1
Monacyclinone K	0
Morakotin A	0
Morakotin C	0
Morakotin D	0
Morakotin E	0
Neoanthraquinone	0
Neomacrophorin X	0
Nidurufin	0
Nidurufin-2'-(4-O-methyl)-beta-D-glucopyranose	0
Nigrosporin B	0
Nigrosporone B	0
Ochracenomicin C	0
Oxyskyrin	0
Paeciloquinone A	0
Paeciloquinone B	0
Paeciloquinone C	0
Paeciloquinone D	0
Paeciloquinone E	0
Paeciloquinone F	0
Paradictyoarthrin B	0
Penicillanthranin A	0
Penicillanthranin B	0
Penipurdin A	0
Phaseolorin I	0
Phomarin	0
Quinofuracin A	0
Quinofuracin B	0
Quinofuracin C	0
Quinofuracin D	0
Rhababerone	0
Rhodoislandin B	0
Saccharosporone A	0
Saccharosporone B	0
Stemphylanthranol A	0
Stemphylanthranol B	0
Termstrin A	0
Termstrin B	0
Torrubiellin B	0
UCT1072M1	0
UCT1072M2	0
Urdamycin X	0
Ustilanthracin A	0
Ustilanthracin B	0
Versicol	0
Versiconol B	0
WS 009 B	0
WS009 A	0
alterporriol E	0
dihydroxyanthraquinone +	354
hexahydroxyanthraquinone +	0
monohydroxyanthraquinone +	1
omega-acetylcarviolin	0
pentahydroxyanthraquinone +	0
robustaquinone A	0
tetrahydroxyanthraquinone +	0
trihydroxyanthraquinone +	239

paths to the root