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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxyanthraquinones
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Accession:CHEBI:37485 term browser browse the term
Definition:An anthraquinone substituted with one or more hydroxy groups.
Synonyms:alt_id: CHEBI:13829;   CHEBI:24672



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2-hydroxychrysophanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases chemical synthesis
multiple interactions
ISO CYP1A2 protein results in increased chemical synthesis of 2-hydroxychrysophanol
[CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol
CTD PMID:29698620 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases chemical synthesis
ISO [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol
CYP3A4 protein results in increased chemical synthesis of 2-hydroxychrysophanol
CTD PMID:29698620 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Alizarin Red S binds to ALB protein CTD PMID:18968587 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
alizarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP1A1 protein CTD PMID:12379470 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO alizarin results in decreased activity of CYP1A2 protein CTD PMID:12379470 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP1B1 protein CTD PMID:12379470 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO alizarin results in decreased activity of CYP2E1 protein CTD PMID:12379470 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO alizarin binds to and results in increased activity of ESR1 protein CTD PMID:20707409 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of alizarin CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of alizarin CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
JBrowse link
Aloe emodin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in decreased expression of ADIPOQ mRNA] CTD PMID:22645054 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO aloe emodin results in increased expression of ATF3 mRNA CTD PMID:22210228 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO aloe emodin results in increased expression of BAX protein CTD PMID:19928967 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO aloe emodin results in decreased expression of BCL2 mRNA; aloe emodin results in decreased expression of BCL2 protein CTD PMID:19928967 PMID:22210228 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
increases expression
ISO aloe emodin results in increased activity of CASP3 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP3; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP3 protein modified form]
aloe emodin results in increased cleavage of CASP3 protein
CTD PMID:19928967 PMID:22210228 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
increases expression
ISO aloe emodin results in increased activity of CASP8 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP8; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP8 protein modified form]
CTD PMID:19928967 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
increases expression
multiple interactions
ISO aloe emodin results in increased activity of CASP9 protein
aloe emodin results in increased expression of CASP9 protein modified form
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP9; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP9 protein modified form]
CTD PMID:19928967 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO aloe emodin results in increased expression of CYCS protein CTD PMID:19928967 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO aloe emodin results in decreased activity of CYP1A1 protein CTD PMID:27633141 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO aloe emodin results in decreased activity of CYP1A2 protein CTD PMID:27633141 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO aloe emodin results in decreased activity of CYP1B1 protein CTD PMID:27633141 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases chemical synthesis
ISO [CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CYP2B6 protein results in increased chemical synthesis of aloe emodin
CTD PMID:29698620 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis
multiple interactions
ISO CYP3A4 protein results in increased chemical synthesis of aloe emodin
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CTD PMID:29698620 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO aloe emodin results in increased expression of DDIT3 mRNA; aloe emodin results in increased expression of DDIT3 protein CTD PMID:22210228 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO aloe emodin results in increased phosphorylation of EIF2S1 protein CTD PMID:22210228 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of FABP4 mRNA] CTD PMID:22645054 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO aloe emodin results in increased expression of and affects the localization of FADD protein CTD PMID:19928967 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO aloe emodin results in increased expression of FAS protein CTD PMID:19928967 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression ISO aloe emodin results in increased expression of FASLG protein CTD PMID:19928967 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO aloe emodin results in increased expression of HSPA5 mRNA; aloe emodin results in increased expression of HSPA5 protein CTD PMID:22210228 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of LPL mRNA] CTD PMID:22645054 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
decreases expression
ISO aloe emodin results in decreased expression of and results in decreased activity of NAT1 protein
aloe emodin results in decreased expression of NAT1 mRNA
CTD PMID:16314733 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] CTD PMID:19352036 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of PPARG mRNA] CTD PMID:22645054 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA] CTD PMID:19352036 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Retn resistin multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of RETN mRNA] CTD PMID:22645054 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO aloe emodin results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO aloe emodin results in decreased activity of SULT1E1 protein CTD PMID:27633141 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of TNF mRNA]
aloe emodin results in increased expression of TNF protein
CTD PMID:19928967 PMID:22645054 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO aloe emodin results in increased expression of TNFRSF1A protein CTD PMID:19928967 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO aloe emodin results in increased expression of TNFRSF1B protein CTD PMID:19928967 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tp53 tumor protein p53 increases expression ISO aloe emodin results in increased expression of TP53 protein CTD PMID:19928967 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO aloe emodin results in increased expression of and affects the localization of TRADD protein CTD PMID:19928967 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of aloe emodin CTD PMID:24854283 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO aloe emodin results in increased splicing of XBP1 mRNA CTD PMID:22210228 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
anthraflavic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 2,6-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Alb albumin affects binding ISO 2,6-dihydroxyanthraquinone binds to ALB protein CTD PMID:16404478 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 2,6-dihydroxyanthraquinone results in increased expression of CYP1A1 mRNA CTD PMID:11502733 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO 2,6-dihydroxyanthraquinone results in increased expression of CYP1B1 mRNA CTD PMID:11502733 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone CTD PMID:12756209 PMID:14557274 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone CTD PMID:14557274 NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 2,6-dihydroxyanthraquinone CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465 JBrowse link
aurantio-obtusin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO aurantio-obtusin results in decreased activity of SLC22A6 protein CTD PMID:29045746 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO aurantio-obtusin results in decreased activity of SLC22A8 protein CTD PMID:29045746 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
chrysazin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO danthron inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
increases expression
ISO danthron affects the localization of and results in increased expression of AIFM1 protein
danthron results in increased expression of AIFM1 mRNA
CTD PMID:21126053 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Alb albumin affects binding ISO danthron binds to ALB protein CTD PMID:16404478 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO danthron results in increased expression of ATF6 protein CTD PMID:21126053 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO danthron results in increased expression of BAX protein CTD PMID:21126053 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO danthron results in decreased expression of BCL2 protein CTD PMID:21126053 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
decreases expression
ISO danthron results in increased expression of BCL2L1 protein
danthron results in decreased expression of BCL2L1 protein
CTD PMID:21126053 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO danthron results in increased expression of BID protein CTD PMID:21126053 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO danthron results in decreased expression of BIRC2 protein CTD PMID:21126053 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO danthron results in increased expression of BIRC3 protein CTD PMID:21126053 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO danthron results in decreased expression of BIRC5 protein CTD PMID:21126053 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
ISO benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP3 protein]; danthron results in increased activity of and results in increased expression of CASP3 protein
danthron results in increased expression of CASP3 mRNA
CTD PMID:21126053 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
ISO benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP8 protein]; danthron results in increased activity of and results in increased expression of CASP8 protein
danthron results in increased expression of CASP8 mRNA
CTD PMID:21126053 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
ISO benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP9 protein]; danthron results in increased activity of and results in increased expression of CASP9 protein
danthron results in increased expression of CASP9 mRNA
CTD PMID:21126053 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO danthron affects the localization of and results in increased expression of CYCS protein CTD PMID:21126053 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO danthron results in increased expression of DDIT3 protein CTD PMID:21126053 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression ISO danthron results in increased expression of DIABLO protein CTD PMID:21126053 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Endog endonuclease G increases expression
multiple interactions
ISO danthron results in increased expression of ENDOG mRNA
danthron affects the localization of and results in increased expression of ENDOG protein
CTD PMID:21126053 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO danthron results in increased expression of FAS protein CTD PMID:21126053 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression ISO danthron results in increased expression of FASLG protein CTD PMID:21126053 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO danthron results in increased expression of HSPA5 protein CTD PMID:21126053 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO danthron results in decreased expression of SOD1 protein CTD PMID:21126053 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO danthron results in decreased expression of SOD2 protein CTD PMID:21126053 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO danthron results in increased expression of TNFSF10 protein CTD PMID:21126053 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO danthron results in decreased expression of XIAP protein CTD PMID:21126053 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
chrysophanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP chrysophanic acid results in decreased expression of ABCB11 mRNA; chrysophanic acid results in decreased expression of ABCB11 protein CTD PMID:28161596 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP chrysophanic acid results in increased expression of ABCC2 mRNA; chrysophanic acid results in increased expression of ABCC2 protein CTD PMID:28161596 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression EXP chrysophanic acid results in increased expression of ABCC4 mRNA; chrysophanic acid results in increased expression of ABCC4 protein CTD PMID:28161596 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO chrysophanic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO chrysophanic acid results in decreased phosphorylation of AKT1 protein CTD PMID:30300626 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO chrysophanic acid results in increased expression of BAK1 protein CTD PMID:30300626 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO chrysophanic acid results in increased expression of BAX protein CTD PMID:30300626 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO chrysophanic acid results in decreased activity of CYP1A1 protein CTD PMID:27633141 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
multiple interactions
increases metabolic processing
ISO chrysophanic acid results in decreased activity of CYP1A2 protein
[CYP1A2 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol
CTD PMID:27633141 PMID:29698620 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO chrysophanic acid results in decreased activity of CYP1B1 protein CTD PMID:27633141 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases metabolic processing
ISO [CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin CTD PMID:29698620 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
increases chemical synthesis
multiple interactions
ISO CYP3A4 protein results in increased metabolism of chrysophanic acid
CYP3A4 protein results in increased chemical synthesis of chrysophanic acid metabolite
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol; [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CTD PMID:29698620 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP chrysophanic acid results in increased expression of CYP7A1 mRNA; chrysophanic acid results in increased expression of CYP7A1 protein CTD PMID:28161596 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP chrysophanic acid results in decreased expression of CYP8B1 mRNA; chrysophanic acid results in decreased expression of CYP8B1 protein CTD PMID:28161596 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO chrysophanic acid results in increased expression of DDIT3 protein CTD PMID:30300626 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
multiple interactions
ISO chrysophanic acid results in increased phosphorylation of EIF2AK3 protein
Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2AK3 protein]
CTD PMID:30300626 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions
ISO chrysophanic acid results in increased phosphorylation of EIF2S1 protein
Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2S1 protein]
CTD PMID:30300626 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO chrysophanic acid results in increased expression of ERN1 protein CTD PMID:30300626 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO chrysophanic acid results in decreased phosphorylation of MAPK1 protein CTD PMID:30300626 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects phosphorylation ISO chrysophanic acid affects the phosphorylation of MAPK14 protein CTD PMID:30300626 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO chrysophanic acid results in decreased phosphorylation of MAPK3 protein CTD PMID:30300626 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 affects phosphorylation ISO chrysophanic acid affects the phosphorylation of MAPK8 protein CTD PMID:30300626 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO chrysophanic acid results in decreased expression of PCNA protein CTD PMID:30300626 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO chrysophanic acid results in decreased phosphorylation of RPS6 protein CTD PMID:30300626 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO chrysophanic acid results in decreased phosphorylation of RPS6KB1 protein CTD PMID:30300626 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP chrysophanic acid results in decreased expression of SLC10A1 mRNA; chrysophanic acid results in decreased expression of SLC10A1 protein CTD PMID:28161596 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO chrysophanic acid results in decreased activity of SLC22A6 protein CTD PMID:29045746 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO chrysophanic acid results in decreased activity of SLC22A8 protein CTD PMID:29045746 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO chrysophanic acid results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of chrysophanic acid CTD PMID:24854283 NCBI chr 9:88,696,981...88,808,465 JBrowse link
Citreorosein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases chemical synthesis ISO CYP2C19 protein results in increased chemical synthesis of 1,3,8-trihydroxy-6-hydroxymethylanthraquinone CTD PMID:27989148 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis ISO CYP3A4 protein results in increased chemical synthesis of 1,3,8-trihydroxy-6-hydroxymethylanthraquinone CTD PMID:27989148 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
emodin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases expression
multiple interactions
decreases expression
EXP
ISO
Emodin results in increased expression of ABCB11 mRNA; Emodin results in increased expression of ABCB11 protein
dorsomorphin inhibits the reaction [Emodin results in decreased expression of ABCB11 mRNA]; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA]
Emodin results in decreased expression of ABCB11 mRNA; Emodin results in decreased expression of ABCB11 protein
CTD PMID:28161596 PMID:30517764 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO
EXP
Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
Emodin results in increased expression of ABCB1A mRNA
ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]
CTD PMID:19549930 PMID:24380838 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP Emodin results in increased expression of ABCB1B mRNA CTD PMID:19549930 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP Emodin results in decreased expression of ABCB4 mRNA CTD PMID:28161596 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
decreases expression
EXP
ISO
Emodin results in increased expression of ABCC2 mRNA
Emodin results in decreased expression of ABCC2 mRNA
Emodin results in decreased expression of ABCC2 mRNA; Emodin results in decreased expression of ABCC2 protein
CTD PMID:19549930 PMID:28161596 PMID:30517764 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
decreases expression
EXP
ISO
Emodin results in increased expression of ABCC3 mRNA
Emodin results in decreased expression of ABCC3 mRNA
Emodin results in decreased expression of ABCC3 mRNA; Emodin results in decreased expression of ABCC3 protein
CTD PMID:19549930 PMID:28161596 PMID:30517764 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression
multiple interactions
EXP
ISO
Emodin results in decreased expression of ABCC4 mRNA; Emodin results in decreased expression of ABCC4 protein
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC4 mRNA]
CTD PMID:28161596 PMID:30517764 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 increases expression EXP Emodin results in increased expression of ABCC6 mRNA CTD PMID:19549930 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression ISO Emodin results in decreased expression of ACTA1 mRNA CTD PMID:16045814 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
EXP Emodin results in decreased expression of ACTA2 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]
CTD PMID:15288473 PMID:27989784 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agt angiotensinogen multiple interactions EXP Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]; Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein] CTD PMID:17886230 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Emodin binds to and results in increased activity of AHR protein
Emodin binds to and results in increased activity of AHR protein; Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD PMID:14644660 PMID:17869316 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
decreases expression
ISO
EXP
[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of AKT1 protein; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; SB 203580 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]; U 0126 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]
Emodin results in decreased expression of AKT1 mRNA
CTD PMID:15288473 PMID:16045814 PMID:17077332 PMID:23848338 PMID:27032576 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ar androgen receptor multiple interactions ISO Emodin inhibits the reaction [cobaltous chloride results in increased expression of AR protein] CTD PMID:23212659 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arg2 arginase 2 decreases expression ISO Emodin results in decreased expression of ARG2 mRNA CTD PMID:21319176 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G Arid3a AT-rich interaction domain 3A increases expression ISO Emodin results in increased expression of ARID3A mRNA CTD PMID:15612046 NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599
JBrowse link
G Atm ATM serine/threonine kinase increases expression
increases phosphorylation
ISO Emodin results in increased expression of ATM mRNA
Emodin results in increased phosphorylation of ATM protein
CTD PMID:16045814 PMID:20855424 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Bag5 BAG cochaperone 5 decreases expression ISO Emodin results in decreased expression of BAG5 mRNA CTD PMID:16045814 NCBI chr 6:130,768,467...130,772,122
Ensembl chr 6:130,768,141...130,772,970
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
decreases expression
multiple interactions
ISO
EXP
Emodin affects the expression of BAX protein
Emodin results in decreased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BAX protein]; SB 203580 affects the reaction [Emodin affects the expression of BAX protein]; U 0126 affects the reaction [Emodin affects the expression of BAX protein]
CTD PMID:19549930 PMID:27032576 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
affects expression
multiple interactions
ISO
EXP
Emodin results in decreased expression of BCL2 mRNA; Emodin results in decreased expression of BCL2 protein
Emodin affects the expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BCL2 protein]; SB 203580 affects the reaction [Emodin affects the expression of BCL2 protein]; U 0126 affects the reaction [Emodin affects the expression of BCL2 protein]
CTD PMID:19549930 PMID:23848338 PMID:27032576 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bfar bifunctional apoptosis regulator decreases expression ISO Emodin results in decreased expression of BFAR mRNA CTD PMID:16045814 NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038
JBrowse link
G Bid BH3 interacting domain death agonist increases degradation
multiple interactions
ISO Emodin results in increased degradation of BID protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased degradation of BID protein]; SB 203580 promotes the reaction [Emodin results in increased degradation of BID protein]
CTD PMID:27032576 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Emodin results in decreased expression of BIRC5 mRNA; Emodin results in decreased expression of BIRC5 protein CTD PMID:23848338 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Canx calnexin decreases expression ISO Emodin results in decreased expression of CANX mRNA CTD PMID:16045814 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
JBrowse link
G Casp1 caspase 1 increases expression ISO Emodin results in increased expression of CASP1 mRNA CTD PMID:15612046 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 decreases expression ISO Emodin results in decreased expression of CASP12 mRNA CTD PMID:21319176 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases expression
affects expression
increases cleavage
multiple interactions
increases activity
ISO
EXP
Emodin results in increased expression of CASP3 protein
Emodin affects the expression of CASP3 protein modified form
Emodin results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of CASP3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Emodin results in increased activity of CASP3 protein]; Emodin results in increased cleavage of and results in increased activity of CASP3 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of CASP3 protein]; U 0126 promotes the reaction [Emodin results in increased cleavage of CASP3 protein]
CTD PMID:19549930 PMID:23848338 PMID:25448808 PMID:27032576 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein]; SB 203580 promotes the reaction [Emodin results in increased activity of CASP8 protein]; U 0126 promotes the reaction [Emodin results in increased activity of CASP8 protein] CTD PMID:27032576 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases expression ISO Emodin results in increased expression of CASP9 mRNA CTD PMID:21319176 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
affects expression
ISO
EXP
Emodin inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein]
Emodin promotes the reaction [Cisplatin results in decreased activity of CAT protein]
Emodin affects the expression of CAT protein
CTD PMID:19549930 PMID:22271272 PMID:26139382 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO Emodin results in decreased expression of CCNB2 mRNA CTD PMID:16045814 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
EXP Emodin results in increased expression of CDH1 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]
CTD PMID:27989784 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdk13 cyclin-dependent kinase 13 decreases expression ISO Emodin results in decreased expression of CDK13 mRNA CTD PMID:16045814 NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Emodin results in decreased expression of CDK4 mRNA CTD PMID:16045814 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO Emodin results in increased expression of CDKN1C mRNA CTD PMID:21319176 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
JBrowse link
G Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 decreases expression ISO Emodin results in decreased expression of CELSR3 mRNA CTD PMID:16045814 NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354
JBrowse link
G Chia chitinase, acidic multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased expression of CHIA mRNA] CTD PMID:22484343 NCBI chr 2:193,614,374...193,656,532
Ensembl chr 2:193,614,114...193,656,533
JBrowse link
G Cidec cell death-inducing DFFA-like effector c decreases expression ISO Emodin results in decreased expression of CIDEC mRNA CTD PMID:21319176 NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Emodin results in decreased expression of COL1A1 mRNA CTD PMID:15288473 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] CTD PMID:19474275 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression EXP Emodin results in decreased expression of COL3A1 mRNA CTD PMID:15288473 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cops5 COP9 signalosome subunit 5 multiple interactions ISO [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein CTD PMID:17077332 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 increases expression ISO Emodin results in increased expression of CSNK2A1 mRNA CTD PMID:21319176 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
JBrowse link
G Csnk2b casein kinase 2 beta increases expression ISO Emodin results in increased expression of CSNK2B mRNA CTD PMID:21319176 NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133
JBrowse link
G Ctsd cathepsin D decreases expression ISO Emodin results in decreased expression of CTSD mRNA CTD PMID:16045814 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA] CTD PMID:18590720 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA] CTD PMID:18590720 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase increases expression ISO Emodin results in increased expression of CYLD mRNA CTD PMID:21319176 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression
ISO Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Emodin results in decreased activity of CYP1A1 protein
Emodin results in increased expression of CYP1A1 mRNA; Emodin results in increased expression of CYP1A1 protein
CTD PMID:11502733 PMID:14644660 PMID:17012224 PMID:27633141 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases hydroxylation
increases oxidation
decreases activity
ISO [CYP1A2 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
CYP1A2 protein results in increased hydroxylation of Emodin
CYP1A2 protein results in increased oxidation of Emodin
Emodin results in decreased activity of CYP1A2 protein
CTD PMID:27633141 PMID:27989148 PMID:30672276 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
decreases activity
ISO Emodin results in increased expression of CYP1B1 mRNA; Emodin results in increased expression of CYP1B1 protein
Emodin results in decreased activity of CYP1B1 protein
CTD PMID:11502733 PMID:14990334 PMID:27633141 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression EXP
ISO
Emodin results in decreased expression of CYP27A1 mRNA CTD PMID:28161596 PMID:30517764 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases oxidation
multiple interactions
ISO CYP2C19 protein results in increased oxidation of Emodin
[CYP2C19 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
CTD PMID:27989148 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases hydroxylation
increases oxidation
ISO [CYP3A4 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
CYP3A4 protein results in increased hydroxylation of Emodin
CYP3A4 protein results in increased oxidation of Emodin
CTD PMID:27989148 PMID:30672276 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Emodin CTD PMID:30672276 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP Emodin results in decreased expression of CYP7A1 mRNA; Emodin results in decreased expression of CYP7A1 protein CTD PMID:28161596 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Emodin results in decreased expression of CYP7B1 mRNA CTD PMID:30517764 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP Emodin results in decreased expression of CYP8B1 mRNA; Emodin results in decreased expression of CYP8B1 protein CTD PMID:28161596 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dct dopachrome tautomerase decreases expression ISO Emodin results in decreased expression of DCT mRNA; Emodin results in decreased expression of DCT protein CTD PMID:26972667 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Emodin results in increased expression of DDIT3 protein CTD PMID:19549930 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dhfr dihydrofolate reductase decreases expression ISO Emodin results in decreased expression of DHFR mRNA CTD PMID:16045814 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO Emodin results in increased expression of DNAJB1 mRNA CTD PMID:16045814 NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458
JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 increases expression ISO Emodin results in increased expression of DYNC1H1 mRNA CTD PMID:21319176 NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
JBrowse link
G E2f5 E2F transcription factor 5 increases expression ISO Emodin results in increased expression of E2F5 mRNA CTD PMID:16045814 NCBI chr 2:86,997,331...87,012,901
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of EGR1 mRNA] CTD PMID:18590720 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein increases expression ISO Emodin results in increased expression of EI24 mRNA CTD PMID:16045814 NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571
JBrowse link
G Eif2b1 eukaryotic translation initiation factor 2B subunit alpha decreases expression ISO Emodin results in decreased expression of EIF2B1 mRNA CTD PMID:16045814 NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Emodin results in increased activity of ESR1 protein CTD PMID:19161236 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO Emodin results in increased activity of ESR2 protein CTD PMID:19161236 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fabp5 fatty acid binding protein 5 decreases expression ISO Emodin results in decreased expression of FABP5 mRNA CTD PMID:15612046 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Fadd Fas associated via death domain increases expression ISO Emodin results in increased expression of FADD mRNA CTD PMID:21319176 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
decreases expression
increases expression
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FAS protein]; U 0126 promotes the reaction [Emodin results in increased expression of FAS protein]
Emodin results in decreased expression of FAS protein
CTD PMID:19549930 PMID:27032576 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FASLG protein]; SB 203580 promotes the reaction [Emodin results in increased expression of FASLG protein]; U 0126 promotes the reaction [Emodin results in increased expression of FASLG protein] CTD PMID:27032576 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fn1 fibronectin 1 decreases expression EXP Emodin results in decreased expression of FN1 mRNA CTD PMID:15288473 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Foxo1 forkhead box O1 increases expression ISO Emodin results in increased expression of FOXO1 mRNA CTD PMID:16045814 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GADD45A mRNA] CTD PMID:30517764 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gas2 growth arrest-specific 2 increases expression ISO Emodin results in increased expression of GAS2 mRNA CTD PMID:16045814 NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) increases expression ISO Emodin results in increased expression of GCNT2 mRNA CTD PMID:15612046 NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611
JBrowse link
G Golga3 golgin A3 increases expression ISO Emodin results in increased expression of GOLGA3 mRNA CTD PMID:21319176 NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Emodin results in increased expression of GPX1 mRNA CTD PMID:16045814 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPX2 mRNA] CTD PMID:30517764 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Emodin promotes the reaction [Cisplatin results in decreased activity of GSR protein] CTD PMID:22271272 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstm3 glutathione S-transferase mu 3 decreases expression ISO Emodin results in decreased expression of GSTM3 mRNA CTD PMID:16045814
G Gstm5 glutathione S-transferase, mu 5 decreases expression ISO Emodin results in decreased expression of GSTM3 mRNA CTD PMID:16045814 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Emodin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO Emodin results in increased expression of H2AX protein modified form
TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]
CTD PMID:20855424 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 decreases expression ISO Emodin results in decreased expression of HACD3 mRNA CTD PMID:16045814 NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA] CTD PMID:21382473 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hils1 histone linker H1 domain, spermatid-specific 1 increases expression ISO Emodin results in increased expression of H1F9 mRNA CTD PMID:21319176 NCBI chr10:79,913,525...79,914,321
Ensembl chr10:79,913,480...79,914,321
JBrowse link
G Hk2 hexokinase 2 increases expression ISO Emodin results in increased expression of HK2 mRNA CTD PMID:21319176 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 protein] CTD PMID:26139382 PMID:30517764 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression
affects glucuronidation
EXP
ISO
Emodin results in decreased expression of HNF4A protein
Emodin results in decreased expression of HNF4A mRNA; Emodin results in decreased expression of HNF4A protein
HNF4A gene SNP affects the glucuronidation of Emodin
CTD PMID:32538071 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Emodin results in increased expression of HSPA5 protein CTD PMID:19549930 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ICAM1 protein] CTD PMID:18590720 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Igsf11 immunoglobulin superfamily, member 11 increases expression ISO Emodin results in increased expression of IGSF11 mRNA CTD PMID:21319176 NCBI chr11:61,733,139...61,884,059
Ensembl chr11:61,733,144...61,868,348
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL10 mRNA] CTD PMID:30517764 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein] CTD PMID:22484343 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il15 interleukin 15 increases expression ISO Emodin results in increased expression of IL15 mRNA CTD PMID:15612046 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL1B protein] CTD PMID:26139382 PMID:30517764 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein] CTD PMID:22484343 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein] CTD PMID:22484343 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein]
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
CTD PMID:18590720 PMID:23848338 PMID:26139382 PMID:30517764 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO Emodin results in decreased expression of ITPR1 mRNA CTD PMID:16045814 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Jag1 jagged canonical Notch ligand 1 multiple interactions
decreases expression
EXP 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]
Emodin results in decreased expression of JAG1 protein
CTD PMID:27989784 NCBI chr 3:124,406,794...124,442,220
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Jak1 Janus kinase 1 decreases phosphorylation
multiple interactions
ISO Emodin results in decreased phosphorylation of JAK1 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]
CTD PMID:23848338 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation
multiple interactions
ISO Emodin results in decreased phosphorylation of JAK2 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]
CTD PMID:23848338 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein CTD PMID:17077332 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Krt19 keratin 19 decreases expression ISO Emodin results in decreased expression of KRT19 mRNA CTD PMID:16045814 NCBI chr10:85,075,835...85,080,552 JBrowse link
G Laptm5 lysosomal protein transmembrane 5 increases expression ISO Emodin results in increased expression of LAPTM5 mRNA CTD PMID:15612046 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Emodin results in decreased expression of LEF1 mRNA CTD PMID:15612046 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G LOC100363405 hypothetical LOC100363405 increases expression ISO Emodin results in increased expression of ZFP37 mRNA CTD PMID:21319176 NCBI chr 5:74,930,335...74,960,075
Ensembl chr 5:74,863,483...74,960,101
JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions ISO [Emodin co-treated with cobaltous chloride] results in increased expression of LRP1 protein CTD PMID:23212659 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 decreases expression ISO Emodin results in decreased expression of MACF1 mRNA CTD PMID:16045814 NCBI chr 5:135,623,729...135,949,097
Ensembl chr 5:135,623,742...135,945,905
JBrowse link
G Maob monoamine oxidase B decreases activity EXP Emodin results in decreased activity of MAOB protein CTD PMID:15120460 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein] CTD PMID:15288473 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein] CTD PMID:15288473 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]
Emodin results in decreased phosphorylation of MAPK1 protein
Emodin results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK1 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with TO-901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]
CTD PMID:15288473 PMID:26972667 PMID:27032576 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO Emodin results in increased expression of MAPK10 mRNA CTD PMID:15612046 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Acetylcysteine inhibits the reaction [Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]]; Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein] CTD PMID:14729614 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]
Emodin results in decreased phosphorylation of MAPK3 protein
Emodin results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with TO-901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]
CTD PMID:15288473 PMID:26972667 PMID:27032576 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Emodin results in decreased expression of MAPT mRNA CTD PMID:16045814 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
increases expression
ISO Emodin results in decreased expression of MCL1 mRNA; Emodin results in decreased expression of MCL1 protein
Emodin results in increased expression of MCL1 mRNA
CTD PMID:21319176 PMID:23848338 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP Emodin results in increased expression of MGMT mRNA CTD PMID:19549930 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO Emodin results in decreased expression of MITF protein CTD PMID:26972667 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein] CTD PMID:18590720 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA] CTD PMID:22484343 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
affects expression
EXP Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]
Emodin affects the expression of MYC protein
CTD PMID:17886230 PMID:19549930 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Mylk myosin light chain kinase increases activity EXP Emodin results in increased activity of MYLK protein CTD PMID:15133857 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 increases expression ISO Emodin results in increased expression of NCOA2 mRNA CTD PMID:21319176 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of NFE2L2 protein]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of NFE2L2 mRNA] CTD PMID:26139382 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression EXP Emodin results in increased expression of NFKB1 protein CTD PMID:19549930 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
ISO Emodin results in increased expression of NFKBIA mRNA
Emodin inhibits the reaction [Ovalbumin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD PMID:16045814 PMID:22484343 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nkx6-2 NK6 homeobox 2 increases expression ISO Emodin results in increased expression of NKX6-2 mRNA CTD PMID:15612046 NCBI chr 1:194,380,149...194,383,533
Ensembl chr 1:194,381,975...194,383,515
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
affects expression
EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NOS2 protein]
Emodin affects the expression of NOS2
CTD PMID:18590720 PMID:23615023 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Notch1 notch receptor 1 decreases expression
multiple interactions
decreases response to substance
EXP Emodin results in decreased expression of NOTCH1 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein]
NOTCH1 protein results in decreased susceptibility to Emodin
CTD PMID:27989784 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Emodin results in increased expression of NR0B2 mRNA CTD PMID:30517764 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Emodin results in increased expression of NR1H3 mRNA; Emodin results in increased expression of NR1H3 protein CTD PMID:26972667 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Emodin results in decreased expression of NR1H4 mRNA; Emodin results in decreased expression of NR1H4 protein CTD PMID:30517764 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity
increases cleavage
multiple interactions
ISO Emodin results in increased activity of PARP1 protein
Emodin results in increased cleavage of PARP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of PARP1 protein]; [U 0126 co-treated with Emodin] results in increased cleavage of PARP1 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]
CTD PMID:23848338 PMID:27032576 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein] CTD PMID:17886230 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdcl phosducin-like decreases expression ISO Emodin results in decreased expression of PDCL mRNA CTD PMID:16045814 NCBI chr 3:21,110,165...21,119,763
Ensembl chr 3:21,110,167...21,119,715
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein] CTD PMID:15288473 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions
decreases expression
EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]
Emodin results in decreased expression of PDGFRB protein
CTD PMID:15288473 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Emodin results in decreased expression of PECAM1 protein CTD PMID:23848338 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 increases expression ISO Emodin results in increased expression of PIK3C3 mRNA CTD PMID:16045814 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 affects expression EXP Emodin affects the expression of PIK3R1 protein CTD PMID:19549930 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
ISO Emodin results in increased expression of PPARG protein
Emodin results in increased stability of and results in increased expression of PPARG mRNA
CTD PMID:25448808 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D increases expression ISO Emodin results in increased expression of PPM1D mRNA CTD PMID:16045814 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
JBrowse link
G Ppp1r1c protein phosphatase 1, regulatory (inhibitor) subunit 1C decreases expression ISO Emodin results in decreased expression of PPP1R1C mRNA CTD PMID:15612046 NCBI chr 3:64,616,700...64,719,696
Ensembl chr 3:64,616,700...64,724,104
JBrowse link
G Prdx6 peroxiredoxin 6 increases expression ISO Emodin results in increased expression of PRDX6 mRNA CTD PMID:16045814 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
JBrowse link
G Prkca protein kinase C, alpha affects localization EXP Emodin affects the localization of PRKCA protein CTD PMID:15133857 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcd protein kinase C, delta decreases expression
affects expression
ISO
EXP
Emodin results in decreased expression of PRKCD mRNA
Emodin affects the expression of PRKCD protein
CTD PMID:16045814 PMID:19549930 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prm3 protamine 3 increases expression ISO Emodin results in increased expression of PRM3 mRNA CTD PMID:21319176 NCBI chr10:4,877,471...4,877,985
Ensembl chr10:4,877,471...4,877,985
JBrowse link
G Ptk2 protein tyrosine kinase 2 affects expression EXP Emodin affects the expression of PTK2 protein CTD PMID:19549930 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 increases expression
multiple interactions
ISO Emodin results in increased expression of PTPN6 protein
PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]
CTD PMID:23848338 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression
multiple interactions
ISO
EXP
Emodin results in decreased expression of RAF1 mRNA
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]
CTD PMID:15288473 PMID:16045814 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rag1 recombination activating 1 decreases expression ISO Emodin results in decreased expression of RAG1 mRNA CTD PMID:15612046 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291
JBrowse link
G Rarb retinoic acid receptor, beta decreases expression ISO Emodin results in decreased expression of RARB mRNA CTD PMID:22609528 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Emodin results in decreased expression of RB1 mRNA CTD PMID:16045814 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rcn2 reticulocalbin 2 increases expression ISO Emodin results in increased expression of RCN2 mRNA CTD PMID:16045814 NCBI chr 8:56,449,206...56,466,253
Ensembl chr 8:56,449,206...56,466,251
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases localization
EXP
ISO
Emodin affects the expression of and affects the localization of RELA protein; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased localization of RELA protein]
Emodin results in decreased localization of RELA protein
Emodin inhibits the reaction [Ovalbumin affects the localization of RELA protein]
CTD PMID:18590720 PMID:19549930 PMID:22484343 PMID:30517764 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Emodin results in decreased expression of RHOA mRNA CTD PMID:16045814 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO Emodin results in decreased expression of ROCK1 mRNA CTD PMID:16045814 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases expression ISO Emodin results in decreased expression of ROCK2 mRNA CTD PMID:16045814 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression ISO Emodin results in decreased expression of SAE1 mRNA CTD PMID:16045814 NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]] CTD PMID:14534369 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression
multiple interactions
EXP
ISO
Emodin results in decreased expression of SLC10A1 mRNA; Emodin results in decreased expression of SLC10A1 protein
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]
CTD PMID:28161596 PMID:30517764 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO Emodin results in decreased activity of SLC22A6 protein CTD PMID:29045746 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO Emodin results in decreased activity of SLC22A8 protein CTD PMID:29045746 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA] CTD PMID:30517764 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Smcp sperm mitochondria-associated cysteine-rich protein increases expression ISO Emodin results in increased expression of SMCP mRNA CTD PMID:21319176 NCBI chr 2:178,160,948...178,165,951
Ensembl chr 2:178,160,127...178,166,001
JBrowse link
G Snu13 small nuclear ribonucleoprotein 13 decreases expression ISO Emodin results in decreased expression of SNU13 mRNA CTD PMID:15612046 NCBI chr 7:113,565,903...113,570,871
Ensembl chr 7:113,565,295...113,570,872
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA] CTD PMID:21382473 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects activity
ISO
EXP
Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA]
Emodin affects the activity of SOD2 protein
CTD PMID:21382473 PMID:23615023 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation ISO Emodin results in decreased phosphorylation of SRC protein CTD PMID:23848338 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 increases expression ISO Emodin results in increased expression of ST8SIA1 mRNA CTD PMID:16045814 NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708
JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects localization
multiple interactions
ISO Emodin affects the localization of STAT3 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein; pervanadate inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]
CTD PMID:23848338 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Emodin results in decreased expression of STIP1 mRNA CTD PMID:16045814 NCBI chr 1:204,209,434...204,228,452
Ensembl chr 1:204,178,932...204,228,476
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO Emodin results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Supt20h SPT20 homolog, SAGA complex component increases expression ISO Emodin results in increased expression of SUPT20H mRNA CTD PMID:16045814 NCBI chr 2:138,897,316...138,930,495
Ensembl chr 2:138,897,416...138,930,495
JBrowse link
G Taok3 TAO kinase 3 decreases expression ISO Emodin results in decreased expression of TAOK3 mRNA CTD PMID:16045814 NCBI chr12:39,314,027...39,394,243
Ensembl chr12:39,314,027...39,461,244
JBrowse link
G Tbcc tubulin folding cofactor C decreases expression ISO Emodin results in decreased expression of TBCC mRNA CTD PMID:16045814 NCBI chr 9:14,098,875...14,100,026
Ensembl chr 9:14,098,868...14,100,042
JBrowse link
G Tcfl5 transcription factor like 5 increases expression ISO Emodin results in increased expression of TCFL5 mRNA CTD PMID:15612046 NCBI chr 3:167,734,471...167,754,174
Ensembl chr 3:167,734,473...167,754,282
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases activity
EXP 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin results in decreased activity of TGFB1 protein]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein] CTD PMID:15288473 PMID:19474275 PMID:27989784 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]
Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of TNF protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]
CTD PMID:14534369 PMID:15313406 PMID:18590720 PMID:26139382 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions
increases activity
ISO Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate]; TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]
Emodin results in increased activity of TOP2A protein
CTD PMID:20855424 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 affects expression EXP Emodin affects the expression of TP53 protein CTD PMID:19549930 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp63 tumor protein p63 increases expression ISO Emodin results in increased expression of TRP63 mRNA CTD PMID:15612046 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link
G Traf2 Tnf receptor-associated factor 2 increases expression
decreases expression
ISO Emodin results in increased expression of TRAF2 mRNA
Emodin results in decreased expression of TRAF2 mRNA
CTD PMID:16045814 PMID:21319176 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 increases expression ISO Emodin results in increased expression of TRPV2 mRNA CTD PMID:15612046 NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
JBrowse link
G Tsga13 testis specific, 13 increases expression ISO Emodin results in increased expression of TSGA13 mRNA CTD PMID:21319176 NCBI chr 4:59,501,773...59,522,925
Ensembl chr 4:59,501,774...59,522,818
JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO Emodin results in decreased expression of TUBB3 mRNA CTD PMID:16045814 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
JBrowse link
G Txnl4b thioredoxin-like 4B decreases expression ISO Emodin results in decreased expression of TXNL4B mRNA CTD PMID:16045814 NCBI chr19:37,530,157...37,539,827
Ensembl chr19:37,530,152...37,538,521
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression ISO Emodin results in decreased expression of TXNRD1 mRNA CTD PMID:16045814 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Tyr tyrosinase decreases activity ISO Emodin results in decreased activity of TYR protein CTD PMID:26972667 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO Emodin results in decreased expression of TYRP1 mRNA; Emodin results in decreased expression of TYRP1 protein CTD PMID:26972667 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I increases expression ISO Emodin results in increased expression of UBE2I mRNA CTD PMID:21319176 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Emodin CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Emodin CTD PMID:14557274 NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Emodin CTD PMID:14557274 PMID:24854283 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Emodin CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases expression ISO
EXP
Emodin results in decreased expression of UGT2B7 mRNA; Emodin results in decreased expression of UGT2B7 protein CTD PMID:32538071 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression ISO Emodin results in decreased expression of VDAC1 mRNA CTD PMID:16045814 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Emodin results in decreased expression of VEGFA mRNA; Emodin results in decreased expression of VEGFA protein CTD PMID:23848338 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin decreases expression
multiple interactions
EXP Emodin results in decreased expression of VIM protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]
CTD PMID:27989784 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 affects expression EXP Emodin affects the expression of XRCC1 protein CTD PMID:19549930 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
JBrowse link
mitoxantrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 affects response to substance ISO ABCA1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Mitoxantrone results in increased expression of ABCB1 protein CTD PMID:15239124 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects export
affects response to substance
increases transport
multiple interactions
increases export
increases expression
decreases abundance
decreases response to substance
increases response to substance
affects transport
affects uptake
ISO ABCG2 protein affects the export of Mitoxantrone
ABCG2 protein affects the susceptibility to Mitoxantrone
ABCG2 protein results in increased transport of Mitoxantrone
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] inhibits the reaction [Folic Acid deficiency results in decreased susceptibility to Mitoxantrone]; [5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; [Folic Acid deficiency results in increased expression of ABCG2 protein] which results in decreased susceptibility to Mitoxantrone; [Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone; Beclomethasone inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Cadmium Chloride inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Dactinomycin inhibits the reaction [Mitoxantrone results in increased expression of ABCG2 mRNA]; desisobutyrylciclesonide inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 gene mutant form results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Haloperidol inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Novobiocin inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Olanzapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; oxfendazole inhibits the reaction [ABCG2 protein affects the transport of Mitoxantrone]; Paliperidone Palmitate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Protons promotes the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Quetiapine Fumarate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Risperidone inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein affects the uptake of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mitoxantrone results in increased expression of ABCG2 mRNA; Mitoxantrone results in increased expression of ABCG2 protein
ABCG2 protein results in decreased abundance of Mitoxantrone
ABCG2 protein results in increased susceptibility to Mitoxantrone
CTD PMID:10606239 PMID:12869632 PMID:15239124 PMID:15640379 PMID:15695404 More... NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain decreases expression ISO Mitoxantrone results in decreased expression of ACADVL protein CTD PMID:34246718 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 affects response to substance ISO ACSL3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 9:80,140,996...80,164,636
Ensembl chr 9:80,115,112...80,164,627
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression ISO Mitoxantrone results in decreased expression of ACTA1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Actg2 actin gamma 2, smooth muscle affects response to substance ISO ACTG2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465
JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 affects response to substance ISO ADARB1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852
JBrowse link
G Agpat5 1-acylglycerol-3-phosphate O-acyltransferase 5 affects response to substance ISO AGPAT5 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr16:70,939,480...70,985,761
Ensembl chr16:70,943,135...70,985,560
JBrowse link
G Ahcyl1 adenosylhomocysteinase-like 1 affects response to substance ISO AHCYL1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member affects response to substance ISO ALDH2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Amotl1 angiomotin-like 1 affects response to substance ISO AMOTL1 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 8:11,348,651...11,467,564
Ensembl chr 8:11,353,674...11,467,573
JBrowse link
G Ank2 ankyrin 2 decreases expression ISO Mitoxantrone results in decreased expression of ANK2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) affects response to substance ISO ASNS protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Ass1 argininosuccinate synthase 1 affects response to substance ISO ASS1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Atm ATM serine/threonine kinase decreases expression
increases phosphorylation
multiple interactions
ISO
EXP
Mitoxantrone results in decreased expression of ATM mRNA
Mitoxantrone results in increased phosphorylation of ATM protein
[Poly(ADP-ribose) Polymerase Inhibitors co-treated with Mitoxantrone] results in increased phosphorylation of ATM protein
CTD PMID:22832221 PMID:29913208 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression ISO Mitoxantrone results in decreased expression of ATP1A2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression ISO Mitoxantrone results in decreased expression of ATP5A1 protein CTD PMID:34246718 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO Mitoxantrone results in decreased expression of ATP5B protein CTD PMID:34246718 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma decreases expression ISO Mitoxantrone results in decreased expression of ATP5C1 protein CTD PMID:34246718 NCBI chr17:68,423,927...68,446,169 JBrowse link
G Atp7a ATPase copper transporting alpha decreases response to substance ISO ATP7A protein results in decreased susceptibility to Mitoxantrone CTD PMID:17510416 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Bace2 beta-secretase 2 affects response to substance ISO BACE2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr11:36,707,473...36,789,550
Ensembl chr11:36,707,458...36,789,546
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Mitoxantrone results in increased expression of BAX mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbx BBX high mobility group box domain containing affects response to substance ISO BBX protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr11:50,381,249...50,628,934
Ensembl chr11:50,381,247...50,623,251
JBrowse link
G Bcam basal cell adhesion molecule (Lutheran blood group) affects response to substance ISO BCAM protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:79,415,016...79,429,403
Ensembl chr 1:79,415,017...79,429,403
JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Mitoxantrone results in increased expression of BCAT1 mRNA CTD PMID:23558518 NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]
Mitoxantrone results in decreased expression of BCL2 mRNA
CTD PMID:8219202 PMID:8840993 PMID:15582267 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein] CTD PMID:8840993 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO Mitoxantrone results in decreased expression of BIRC2 protein CTD PMID:15359644 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects expression
increases expression
ISO Mitoxantrone affects the expression of BIRC5 mRNA
Mitoxantrone results in increased expression of BIRC5 protein
CTD PMID:16638212 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmp7 bone morphogenetic protein 7 affects response to substance ISO BMP7 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 affects response to substance ISO BST2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr16:18,217,404...18,220,979
Ensembl chr16:18,217,407...18,220,979
JBrowse link
G Btbd3 BTB domain containing 3 affects response to substance ISO BTBD3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:125,591,427...125,621,660
Ensembl chr 3:125,591,490...125,619,038
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G decreases expression ISO Mitoxantrone results in decreased expression of CACNA1G mRNA CTD PMID:26537877 PMID:28940058 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 decreases expression ISO Mitoxantrone results in decreased expression of CACNA2D2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173
JBrowse link
G Calr calreticulin affects localization ISO Mitoxantrone affects the localization of CALR protein CTD PMID:20003823 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 affects response to substance ISO CAMK2N1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600
JBrowse link
G Casc3 CASC3 exon junction complex subunit affects response to substance ISO CASC3 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr10:83,769,014...83,788,966
Ensembl chr10:83,769,001...83,788,966
JBrowse link
G Casp2 caspase 2 increases expression
increases splicing
ISO Mitoxantrone results in increased expression of CASP2 mRNA alternative form
Mitoxantrone results in increased splicing of CASP2 mRNA
CTD PMID:14757846 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP3 protein]
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]
CTD PMID:8840993 PMID:12948851 PMID:16215684 PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 increases activity ISO Mitoxantrone results in increased activity of CASP6 protein CTD PMID:12948851 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Mitoxantrone results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP7 protein]
CTD PMID:12948851 PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity ISO Mitoxantrone results in increased activity of CASP8 protein CTD PMID:12948851 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Mitoxantrone results in increased activity of CASP9 protein CTD PMID:12948851 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases activity EXP Mitoxantrone results in decreased activity of CAT protein CTD PMID:29913208 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cavin3 caveolae associated protein 3 affects response to substance ISO CAVIN3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161
JBrowse link
G Cavin4 caveolae associated protein 4 decreases expression ISO Mitoxantrone results in decreased expression of CAVIN4 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 5:62,996,975...63,004,819
Ensembl chr 5:62,996,865...63,007,678
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) affects response to substance ISO CD55 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link
G Celf2 CUGBP, Elav-like family member 2 affects response to substance ISO CELF2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333
JBrowse link
G Ces2h carboxylesterase 2H affects response to substance ISO CES2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Chrdl1 chordin-like 1 affects response to substance ISO CHRDL1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr  X:106,889,125...106,992,937
Ensembl chr  X:106,889,125...106,992,921
JBrowse link
G Cklf chemokine-like factor affects response to substance ISO CKLF protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr19:698,097...706,570
Ensembl chr19:698,033...706,570
JBrowse link
G Ckm creatine kinase, M-type decreases expression ISO Mitoxantrone results in decreased expression of CKM mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Clns1a chloride nucleotide-sensitive channel 1A affects response to substance ISO CLNS1A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:152,019,369...152,039,670
Ensembl chr 1:152,019,378...152,039,661
JBrowse link
G Clu clusterin affects response to substance ISO CLU protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Coch cochlin affects response to substance ISO COCH protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109
JBrowse link
G Col11a1 collagen type XI alpha 1 chain affects response to substance ISO COL11A1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
JBrowse link
G Corin corin, serine peptidase decreases expression ISO Mitoxantrone results in decreased expression of CORIN mRNA CTD PMID:26537877 PMID:28940058 NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503
JBrowse link
G Cpvl carboxypeptidase, vitellogenic-like affects response to substance ISO CPVL protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:82,981,421...83,091,730
Ensembl chr 4:82,981,422...83,085,655
JBrowse link
G Crebl2 cAMP responsive element binding protein-like 2 affects response to substance ISO CREBL2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:167,673,359...167,699,299
Ensembl chr 4:167,673,315...167,699,292
JBrowse link
G Cs citrate synthase decreases activity ISO Mitoxantrone results in decreased activity of CS protein CTD PMID:34246718 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Csrnp2 cysteine and serine rich nuclear protein 2 affects response to substance ISO CSRNP2 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 7:131,594,232...131,610,075
Ensembl chr 7:131,594,232...131,610,075
JBrowse link
G Cth cystathionine gamma-lyase affects response to substance ISO CTH protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule affects response to substance ISO CXADR protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr11:16,982,752...17,030,078
Ensembl chr11:16,982,860...17,030,046
JBrowse link
G Dapk1 death associated protein kinase 1 affects response to substance ISO DAPK1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 affects response to substance ISO DDIT4 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Dhrs2 dehydrogenase/reductase 2 affects response to substance ISO DHRS2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644
JBrowse link
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease affects response to substance ISO DIS3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642
JBrowse link
G Dmd dystrophin decreases expression ISO Mitoxantrone results in decreased expression of DMD mRNA CTD PMID:26537877 PMID:28940058 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207
JBrowse link
G Dusp4 dual specificity phosphatase 4 affects response to substance
increases expression
ISO DUSP4 protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in increased expression of DUSP4 mRNA
CTD PMID:16217747 PMID:26537877 PMID:28940058 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 affects response to substance ISO DYRK2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106
JBrowse link
G Egr1 early growth response 1 affects response to substance ISO EGR1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha affects response to substance ISO EIF2S1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A affects response to substance ISO EIF5A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
JBrowse link
G Elavl4 ELAV like RNA binding protein 4 affects response to substance ISO ELAVL4 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 5:125,056,848...125,200,543
Ensembl chr 5:125,056,848...125,200,446
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 affects response to substance ISO ELOVL5 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 8:78,790,799...78,857,307
Ensembl chr 8:78,790,846...78,857,284
JBrowse link
G En2 engrailed homeobox 2 affects response to substance ISO EN2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:7,221,096...7,226,943
Ensembl chr 4:7,221,096...7,226,943
JBrowse link
G Enc1 ectodermal-neural cortex 1 affects response to substance ISO ENC1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
JBrowse link
G Epb41l2 erythrocyte membrane protein band 4.1-like 2 affects response to substance ISO EPB41L2 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 1:19,863,010...20,037,795
Ensembl chr 1:19,863,009...20,037,721
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases response to substance
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone] CTD PMID:21712253 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression ISO Mitoxantrone results in decreased expression of ERBB3 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Etfdh electron transfer flavoprotein dehydrogenase decreases expression ISO Mitoxantrone results in decreased expression of ETFDH protein CTD PMID:34246718 NCBI chr 2:164,740,547...164,762,754
Ensembl chr 2:164,729,749...164,762,745
JBrowse link
G Evi5 ecotropic viral integration site 5 affects response to substance ISO EVI5 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678
JBrowse link
G Extl2 exostosin-like glycosyltransferase 2 affects response to substance ISO EXTL2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:203,922,217...203,946,940
Ensembl chr 2:203,922,187...203,943,653
JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP Mitoxantrone results in increased expression of FABP3 protein CTD PMID:22878004 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Fam117a family with sequence similarity 117, member A affects response to substance ISO FAM117A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr10:80,281,408...80,325,343
Ensembl chr10:80,281,408...80,325,343
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO Hydrocortisone promotes the reaction [Mitoxantrone results in increased expression of FAS]
Mitoxantrone results in increased expression of FAS mRNA; Mitoxantrone results in increased expression of FAS protein
CTD PMID:9676859 PMID:26537877 PMID:28940058 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fasn fatty acid synthase decreases response to substance
multiple interactions
ISO FASN protein results in decreased susceptibility to Mitoxantrone
orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]
CTD PMID:18281512 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 affects response to substance ISO FDFT1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Mitoxantrone results in increased expression of FHL1 mRNA CTD PMID:23558518 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928
JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 affects response to substance ISO FLRT3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841
JBrowse link
G Fndc3a fibronectin type III domain containing 3a affects response to substance ISO FNDC3A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:47,689,909...47,867,354
Ensembl chr15:47,689,919...47,866,784
JBrowse link
G Foxf2 forkhead box F2 affects response to substance ISO FOXF2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr17:32,835,730...32,842,555 JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase affects response to substance ISO FYN protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
JBrowse link
G Fzd2 frizzled class receptor 2 affects response to substance ISO FZD2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
JBrowse link
G Gch1 GTP cyclohydrolase 1 affects response to substance ISO GCH1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Mitoxantrone results in increased expression of GDF15 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Glul glutamate-ammonia ligase affects response to substance ISO GLUL protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Mitoxantrone results in increased expression of GPX1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx3 glutathione peroxidase 3 affects response to substance ISO GPX3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 affects response to substance ISO GUCY1B1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO
EXP
Mitoxantrone results in increased expression of H2AX protein
Poly(ADP-ribose) Polymerase Inhibitors affects the reaction [Mitoxantrone results in increased expression of H2AX protein]
CTD PMID:24994473 PMID:29913208 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression ISO Mitoxantrone results in decreased expression of HADHB protein CTD PMID:34246718 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
JBrowse link
G Hdac4 histone deacetylase 4 affects response to substance ISO HDAC4 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
JBrowse link
G Hmg20b high mobility group 20 B affects response to substance ISO HMG20B protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:8,368,934...8,373,650
Ensembl chr 7:8,368,990...8,373,640
JBrowse link
G Hoxa5 homeo box A5 affects response to substance ISO HOXA5 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234
JBrowse link
G Hrc histidine rich calcium binding protein decreases expression ISO Mitoxantrone results in decreased expression of HRC mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 affects response to substance ISO HSPA2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha affects response to substance
decreases expression
ISO IDH3A protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in decreased expression of IDH3A protein
CTD PMID:16217747 PMID:34246718 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 affects response to substance ISO IFITM1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169
JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects response to substance ISO IGF1R protein affects the susceptibility to Mitoxantrone CTD PMID:15499378 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 affects response to substance ISO IGF2BP3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects response to substance ISO IGFBP3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 affects response to substance ISO IGFBP7 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314
JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 affects response to substance ISO IL13RA2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381
JBrowse link
G Immt inner membrane mitochondrial protein decreases expression ISO Mitoxantrone results in decreased expression of IMMT protein CTD PMID:34246718 NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 affects response to substance ISO IQGAP1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755
JBrowse link
G Irf7 interferon regulatory factor 7 affects response to substance ISO IRF7 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Irx1 iroquois homeobox 1 affects response to substance ISO IRX1 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 1:31,294,615...31,300,444
Ensembl chr 1:31,294,615...31,300,444
JBrowse link
G Irx4 iroquois homeobox 4 decreases expression ISO Mitoxantrone results in decreased expression of IRX4 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier affects response to substance ISO ISG15 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 affects response to substance ISO ISG20 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Jak2 Janus kinase 2 decreases expression ISO Mitoxantrone results in decreased expression of JAK2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in increased expression of JUN mRNA] CTD PMID:8219202 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 affects response to substance ISO KCNAB2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:162,899,511...162,988,057
Ensembl chr 5:162,901,896...162,988,243
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases expression ISO Mitoxantrone results in decreased expression of KCNH2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 increases expression ISO Mitoxantrone results in increased expression of KCNJ2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr10:96,060,849...96,071,401
Ensembl chr10:96,060,821...96,071,445
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 decreases expression ISO Mitoxantrone results in decreased expression of KCNQ1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669
JBrowse link
G Krr1 KRR1, small subunit processome component homolog affects response to substance ISO KRR1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:47,475,557...47,486,996
Ensembl chr 7:47,475,557...47,486,985
JBrowse link
G Lama2 laminin subunit alpha 2 affects response to substance ISO LAMA2 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530
JBrowse link
G Lamb1 laminin subunit beta 1 affects response to substance ISO LAMB1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585
JBrowse link
G Lamc1 laminin subunit gamma 1 affects response to substance ISO LAMC1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492
JBrowse link
G Lbh LBH regulator of WNT signaling pathway affects response to substance ISO LBH protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079
JBrowse link
G Ldb3 LIM domain binding 3 decreases expression ISO Mitoxantrone results in decreased expression of LDB3 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:9,855,768...9,920,108
Ensembl chr16:9,855,927...9,918,532
JBrowse link
G Lemd2 LEM domain nuclear envelope protein 2 affects response to substance ISO LEMD2 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626
JBrowse link
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 affects response to substance ISO LGR4 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:96,447,385...96,550,006
Ensembl chr 3:96,447,858...96,548,899
JBrowse link
G Lipa lipase A, lysosomal acid type affects response to substance ISO LIPA protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:232,024,351...232,167,329
Ensembl chr 1:232,024,356...232,057,633
JBrowse link
G Lipg lipase G, endothelial type affects response to substance ISO LIPG protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Mitoxantrone results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
JBrowse link
G Lmnb1 lamin B1 multiple interactions ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein CTD PMID:15582267 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
JBrowse link
G Macrod1 mono-ADP ribosylhydrolase 1 affects response to substance ISO MACROD1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:204,246,238...204,387,027
Ensembl chr 1:204,246,166...204,389,716
JBrowse link
G Maff MAF bZIP transcription factor F affects response to substance ISO MAFF mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
JBrowse link
G Maged1 MAGE family member D1 affects response to substance ISO MAGED1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr  X:59,422,715...59,429,381
Ensembl chr  X:59,422,717...59,429,364
JBrowse link
G Mdh2 malate dehydrogenase 2 decreases expression ISO Mitoxantrone results in decreased expression of MDH2 protein CTD PMID:34246718 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases response to substance ISO MDM2 promoter SNP results in decreased susceptibility to Mitoxantrone CTD PMID:17575151 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mest mesoderm specific transcript affects response to substance ISO MEST protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:59,354,447...59,366,145
JBrowse link
G Mocos molybdenum cofactor sulfurase affects response to substance ISO MOCOS protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr18:15,931,654...15,977,415
Ensembl chr18:15,931,654...15,977,187
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 affects response to substance ISO MPC2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase affects response to substance ISO MTHFD2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
JBrowse link
G Mxi1 MAX interactor 1, dimerization protein affects response to substance ISO MXI1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
ISO Mitoxantrone results in decreased expression of MYC mRNA
Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in decreased expression of MYC mRNA]
CTD PMID:8219202 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Mycbp2 MYC binding protein 2 affects response to substance ISO MYCBP2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:79,937,354...80,175,432
Ensembl chr15:79,937,354...80,175,498
JBrowse link
G Myh6 myosin heavy chain 6 decreases expression ISO Mitoxantrone results in decreased expression of MYH6 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Myh7 myosin heavy chain 7 decreases expression ISO Mitoxantrone results in decreased expression of MYH7 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myom2 myomesin 2 decreases expression ISO Mitoxantrone results in decreased expression of MYOM2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase affects response to substance ISO NAMPT protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Ndufs5 NADH:ubiquinone oxidoreductase subunit S5 affects response to substance ISO NDUFS5 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603
JBrowse link
G Nefh neurofilament heavy chain affects response to substance ISO NEFH protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nid2 nidogen 2 affects response to substance ISO NID2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,458,084...4,513,843
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO Mitoxantrone results in decreased activity of NR3C1 protein CTD PMID:19255438 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 affects response to substance ISO NR4A2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Nrap nebulin-related anchoring protein decreases expression ISO Mitoxantrone results in decreased expression of NRAP mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:255,350,113...255,427,704
Ensembl chr 1:255,350,113...255,427,693
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 affects response to substance ISO NRIP1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 affects response to substance ISO OXCT1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:53,236,370...53,384,715
Ensembl chr 2:53,236,368...53,384,714
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 affects response to substance ISO P4HA1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
JBrowse link
G Pacrgl parkin coregulated like affects response to substance ISO PACRGL mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr14:62,532,019...62,556,987
Ensembl chr14:62,532,030...62,556,993
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein] CTD PMID:8840993 PMID:15582267 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pbx1 PBX homeobox 1 affects response to substance ISO PBX1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594
JBrowse link
G Pde4d phosphodiesterase 4D affects response to substance ISO PDE4D protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
JBrowse link
G Pde8a phosphodiesterase 8A affects response to substance ISO PDE8A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 decreases expression ISO Mitoxantrone results in decreased expression of PDHA1 protein CTD PMID:34246718 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311
JBrowse link
G Phb2 prohibitin 2 decreases expression ISO Mitoxantrone results in decreased expression of PHB2 protein CTD PMID:34246718 NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272
JBrowse link
G Phgdh phosphoglycerate dehydrogenase affects response to substance ISO PHGDH protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:185,906,964...185,936,160
Ensembl chr 2:185,906,966...185,935,944
JBrowse link
G Plagl1 PLAG1 like zinc finger 1 affects response to substance ISO PLAGL1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228
JBrowse link
G Plat plasminogen activator, tissue type affects response to substance ISO PLAT protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plcb4 phospholipase C, beta 4 affects response to substance ISO PLCB4 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392
JBrowse link
G Plpbp pyridoxal phosphate binding protein affects response to substance ISO PLPBP protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr16:65,003,292...65,014,886
Ensembl chr16:65,002,223...65,014,886
JBrowse link
G Pml PML nuclear body scaffold affects mutagenesis ISO Mitoxantrone affects the mutagenesis of PML gene CTD PMID:19884644 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 affects response to substance ISO PPP1R2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463
JBrowse link
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A decreases expression ISO Mitoxantrone results in decreased expression of PPP1R3A mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 4:42,937,353...42,980,195
Ensembl chr 4:42,939,599...42,980,638
JBrowse link
G Prdm16 PR/SET domain 16 decreases expression ISO Mitoxantrone results in decreased expression of PRDM16 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601
JBrowse link
G Prdx2 peroxiredoxin 2 affects response to substance ISO PRDX2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Prelid3b PRELI domain containing 3B affects response to substance ISO PRELID3B protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:163,263,059...163,271,055
Ensembl chr 3:163,262,985...163,271,181
JBrowse link
G Prkx protein kinase, X-linked increases expression ISO Mitoxantrone results in increased expression of PRKX mRNA CTD PMID:26537877 PMID:28940058 NCBI chr  X:41,823,349...41,866,844
Ensembl chr  X:41,823,355...41,866,669
JBrowse link
G Ptpre protein tyrosine phosphatase, receptor type, E affects response to substance ISO PTPRE protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:190,344,331...190,494,815
Ensembl chr 1:190,344,401...190,489,534
JBrowse link
G Pygm glycogen phosphorylase, muscle associated decreases expression ISO Mitoxantrone results in decreased expression of PYGM mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368
JBrowse link
G Rara retinoic acid receptor, alpha affects mutagenesis ISO Mitoxantrone affects the mutagenesis of RARA gene CTD PMID:19884644 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO Mitoxantrone results in increased expression of RARB mRNA alternative form CTD PMID:17608728 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rasa1 RAS p21 protein activator 1 affects response to substance ISO RASA1 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854
JBrowse link
G Rbbp8 RB binding protein 8, endonuclease affects response to substance ISO RBBP8 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846
JBrowse link
G Rbm17 RNA binding motif protein 17 multiple interactions
decreases response to substance
ISO LY 117018 inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]; Tamoxifen inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone] CTD PMID:16061639 NCBI chr17:66,937,140...66,954,034
Ensembl chr17:66,937,140...66,954,014
JBrowse link
G Rcbtb1 RCC1 and BTB domain containing protein 1 affects response to substance ISO RCBTB1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:33,319,586...33,362,421
Ensembl chr15:33,319,586...33,365,302
JBrowse link
G Rchy1 ring finger and CHY zinc finger domain containing 1 affects response to substance ISO RCHY1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:16,113,263...16,129,017
Ensembl chr14:16,113,224...16,129,167
JBrowse link
G RGD1306063 similar to HT021 affects response to substance ISO C3ORF14 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838
JBrowse link
G Rgs2 regulator of G-protein signaling 2 affects response to substance ISO RGS2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Mitoxantrone results in increased expression of RND1 mRNA CTD PMID:23558518 NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
JBrowse link
G Rragd Ras-related GTP binding D affects response to substance ISO RRAGD mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356
JBrowse link
G Runx3 RUNX family transcription factor 3 affects response to substance ISO RUNX3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:147,393,926...147,419,161
Ensembl chr 5:147,360,994...147,419,156
JBrowse link
G Ryr2 ryanodine receptor 2 decreases expression ISO Mitoxantrone results in decreased expression of RYR2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G Sall2 spalt-like transcription factor 2 affects response to substance ISO SALL2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:25,021,345...25,038,918
Ensembl chr15:25,021,345...25,038,918
JBrowse link
G Satb2 SATB homeobox 2 affects response to substance ISO SATB2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707
JBrowse link
G Scd stearoyl-CoA desaturase affects response to substance ISO SCD protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Schip1 schwannomin interacting protein 1 affects response to substance ISO SCHIP1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 decreases expression ISO Mitoxantrone results in decreased expression of SCN2B mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases expression ISO Mitoxantrone results in decreased expression of SCN5A mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Sdc2 syndecan 2 affects response to substance ISO SDC2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081
JBrowse link
G Sec31a SEC31 homolog A, COPII coat complex component affects response to substance ISO SEC31A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273
JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Mitoxantrone results in increased expression of SERPINE1 mRNA CTD PMID:23558518 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sfn stratifin affects response to substance ISO SFN protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 Ensembl chr 5:145,826,201...145,831,314 JBrowse link
G Sfrp4 secreted frizzled-related protein 4 affects response to substance ISO SFRP4 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736
JBrowse link
G Slc16a6 solute carrier family 16, member 6 affects response to substance ISO SLC16A6 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr10:94,424,377...94,447,984
Ensembl chr10:94,426,244...94,448,779
JBrowse link
G Slc25a11 solute carrier family 25 member 11 decreases expression ISO Mitoxantrone results in decreased expression of SLC25A11 protein CTD PMID:34246718 NCBI chr10:55,358,163...55,360,278
Ensembl chr10:55,357,597...55,360,410
JBrowse link
G Slc7a5 solute carrier family 7 member 5 affects response to substance ISO SLC7A5 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 affects response to substance ISO SLCO4A1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305
JBrowse link
G Smad2 SMAD family member 2 affects response to substance ISO SMAD2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 affects response to substance ISO SORBS1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169
JBrowse link
G Spon1 spondin 1 affects response to substance ISO SPON1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226
JBrowse link
G Spon2 spondin 2 affects response to substance ISO SPON2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:77,505,695...77,518,001
Ensembl chr14:77,511,901...77,517,996
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Mitoxantrone results in increased expression of SPP1 mRNA CTD PMID:23558518 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 affects response to substance ISO SRD5A1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta decreases expression ISO Mitoxantrone results in decreased expression of SUCLA2 protein CTD PMID:34246718 NCBI chr15:48,752,356...48,805,495
Ensembl chr15:48,752,312...48,805,138
JBrowse link
G Sytl2 synaptotagmin-like 2 affects response to substance ISO SYTL2 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 1:144,272,870...144,379,310
Ensembl chr 1:144,273,360...144,379,222
JBrowse link
G Tagln transgelin affects response to substance ISO TAGLN protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member affects response to substance ISO TAP1 protein affects the susceptibility to Mitoxantrone CTD PMID:17523305 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
JBrowse link
G Tbc1d8 TBC1 domain family, member 8 affects response to substance ISO TBC1D8 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 9:41,651,394...41,761,432
Ensembl chr 9:41,651,395...41,761,409
JBrowse link
G Tff3 trefoil factor 3 affects response to substance ISO TFF3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Mitoxantrone results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein affects response to substance ISO TIA1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Mitoxantrone results in increased expression of TIMP1 mRNA CTD PMID:23558518 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tmem47 transmembrane protein 47 affects response to substance ISO TMEM47 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr  X:45,421,405...45,447,900
Ensembl chr  X:45,421,405...45,447,900
JBrowse link
G Tnks tankyrase affects response to substance ISO TNKS protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260
JBrowse link
G Tnnt1 troponin T1, slow skeletal type decreases expression ISO Mitoxantrone results in decreased expression of TNNT1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721
JBrowse link
G Tpd52 tumor protein D52 affects response to substance ISO TPD52 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:92,735,246...92,816,079
Ensembl chr 2:92,735,620...92,816,622
JBrowse link
G Tpm1 tropomyosin 1 affects response to substance ISO TPM1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802
JBrowse link
G Trib1 tribbles pseudokinase 1 affects response to substance ISO TRIB1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
JBrowse link
G Trim2 tripartite motif-containing 2 affects response to substance ISO TRIM2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927
JBrowse link
G Ubl3 ubiquitin-like 3 affects response to substance ISO UBL3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr12:6,473,684...6,518,331
Ensembl chr12:6,473,460...6,518,862
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 affects response to substance ISO UCHL1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:41,485,033...41,495,590
Ensembl chr14:41,485,031...41,495,590
JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein affects response to substance ISO UQCRH protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242
JBrowse link
G Utrn utrophin affects response to substance ISO UTRN protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313
JBrowse link
G Vcan versican affects response to substance ISO VCAN protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression ISO Mitoxantrone results in decreased expression of VDAC1 protein CTD PMID:34246718 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 affects response to substance ISO WARS1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
JBrowse link
G Washc3 WASH complex subunit 3 affects response to substance ISO WASHC3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:22,621,078...22,665,550
Ensembl chr 7:22,621,078...22,690,696
JBrowse link
G Xiap X-linked inhibitor of apoptosis affects localization
decreases expression
ISO Mitoxantrone affects the localization of XIAP protein
Mitoxantrone results in decreased expression of XIAP protein
CTD PMID:15359644 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Zfand1 zinc finger AN1-type containing 1 affects response to substance ISO ZFAND1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:91,444,431...91,457,518
Ensembl chr 2:91,444,508...91,453,246
JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO Mitoxantrone results in increased expression of ZMAT3 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 2:115,106,050...115,136,863
Ensembl chr 2:115,106,966...115,136,863
JBrowse link
G Zscan18 zinc finger and SCAN domain containing 18 affects response to substance ISO ZSCAN18 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:73,332,883...73,349,846
Ensembl chr 1:73,332,889...73,345,897
JBrowse link
Obtusifolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO obtusifolin results in decreased activity of SLC22A6 protein CTD PMID:29045746 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO obtusifolin results in decreased activity of SLC22A8 protein CTD PMID:29045746 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
physcion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases expression EXP physcione results in increased expression of ABCB11 mRNA; physcione results in increased expression of ABCB11 protein CTD PMID:28161596 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP physcione results in decreased expression of ABCB4 mRNA CTD PMID:28161596 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP physcione results in decreased expression of ABCC2 mRNA; physcione results in decreased expression of ABCC2 protein CTD PMID:28161596 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP physcione results in decreased expression of ABCC3 mRNA; physcione results in decreased expression of ABCC3 protein CTD PMID:28161596 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
decreases expression
ISO physcione results in increased expression of BAX protein
physcione results in decreased expression of BAX protein
CTD PMID:22285236 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO physcione results in decreased activity of CYP1A2 protein CTD PMID:27633141 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression EXP physcione results in decreased expression of CYP27A1 mRNA CTD PMID:28161596 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases hydroxylation ISO CYP2B6 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases hydroxylation ISO CYP2C19 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation ISO CYP3A4 protein results in increased hydroxylation of physcione CTD PMID:29667811 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP physcione results in decreased expression of CYP8B1 mRNA; physcione results in decreased expression of CYP8B1 protein CTD PMID:28161596 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP physcione results in decreased expression of SLC10A1 mRNA; physcione results in decreased expression of SLC10A1 protein CTD PMID:28161596 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO physcione results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of physcione CTD PMID:24854283 NCBI chr 9:88,696,981...88,808,465 JBrowse link
purpurin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO purpurin results in decreased phosphorylation of AKT1 protein CTD PMID:33368780 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO purpurin results in increased expression of BAX mRNA CTD PMID:33368780 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO purpurin results in decreased expression of BCL2 mRNA CTD PMID:33368780 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases expression ISO purpurin results in increased expression of CASP3 mRNA CTD PMID:33368780 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases expression ISO purpurin results in increased expression of CASP9 mRNA CTD PMID:33368780 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO purpurin results in decreased expression of CCND1 protein CTD PMID:33368780 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
increases activity
ISO purpurin results in decreased activity of CYP1A1 protein
purpurin results in increased expression of CYP1A1 mRNA
purpurin results in increased activity of CYP1A1 protein
CTD PMID:11502733 PMID:12379470 PMID:12744663 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases activity
ISO purpurin results in decreased activity of CYP1A2 protein
purpurin results in increased activity of CYP1A2 protein
CTD PMID:12379470 PMID:12744663 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
increases expression
ISO purpurin results in decreased activity of CYP1B1 protein
purpurin results in increased expression of CYP1B1 mRNA
CTD PMID:11502733 PMID:12379470 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity ISO purpurin results in increased activity of CYP2B1 protein CTD PMID:12744663 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO purpurin results in decreased activity of CYP2E1 protein CTD PMID:12379470 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO purpurin results in decreased expression of EGFR protein CTD PMID:33368780 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Lhpp phospholysine phosphohistidine inorganic pyrophosphate phosphatase increases expression ISO purpurin results in increased expression of LHPP protein CTD PMID:33368780 NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
increases activity
ISO 3-amino-1-methyl-5H-pyrido(4,3-b)indole promotes the reaction [purpurin results in increased activity of POR protein] CTD PMID:12744663 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
quinizarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 1,4-dihydroxyanthraquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Alb albumin affects binding ISO 1,4-dihydroxyanthraquinone binds to ALB protein CTD PMID:16404478 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 1,4-dihydroxyanthraquinone binds to and results in increased activity of ESR1 protein CTD PMID:20707409 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone CTD PMID:14557274 NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 1,4-dihydroxyanthraquinone CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465 JBrowse link
Rhein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:12546737 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO rhein inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO rhein results in decreased activity of ALKBH2 protein CTD PMID:31088072 NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO rhein results in increased expression of BAX protein CTD PMID:31436023 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Becn1 beclin 1 decreases expression ISO rhein results in decreased expression of BECN1 protein CTD PMID:31436023 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 decreases expression ISO rhein results in decreased expression of CASP3 protein CTD PMID:31436023 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO rhein results in increased cleavage of CASP8 protein CTD PMID:31436023 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 decreases expression ISO rhein results in decreased expression of CASP9 protein CTD PMID:31436023 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO rhein results in decreased activity of CYP1A1 protein CTD PMID:27633141 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO rhein results in decreased activity of CYP1A2 protein CTD PMID:27633141 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Egf epidermal growth factor decreases expression ISO rhein results in decreased expression of EGF protein CTD PMID:21457705 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO rhein results in decreased expression of ERBB2 protein CTD PMID:21457705 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions
ISO rhein results in decreased expression of HIF1A protein
rhein inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]
CTD PMID:21457705 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Ifng interferon gamma increases expression
multiple interactions
ISO rhein results in increased expression of IFNG protein
rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]
CTD PMID:26784856 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein] CTD PMID:26784856 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il17a interleukin 17A increases expression ISO rhein results in increased expression of IL17A protein CTD PMID:26784856 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il2 interleukin 2 increases expression ISO rhein results in increased expression of IL2 protein CTD PMID:26784856 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions ISO rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:26784856 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization
decreases activity
ISO rhein affects the localization of NFKB1 protein
rhein results in decreased activity of NFKB1 protein
CTD PMID:21457705 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO rhein results in decreased expression of PTGS2 protein CTD PMID:21457705 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity
multiple interactions
affects localization
ISO rhein results in decreased activity of RELA protein
cobaltous chloride promotes the reaction [rhein affects the localization of RELA protein]
CTD PMID:21457705 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO rhein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:28890383 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO rhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate] CTD PMID:28890383 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO rhein results in increased expression of SQSTM1 protein CTD PMID:31436023 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO rhein results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:12546737 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO rhein results in increased expression of TNF protein
rhein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:26784856 PMID:31436023 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO rhein results in increased expression of TRADD protein CTD PMID:31436023 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO rhein results in increased expression of TRAF1 protein CTD PMID:31436023 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
decreases response to substance
ISO rhein results in decreased expression of VEGFA protein
rhein results in decreased susceptibility to VEGFA protein
CTD PMID:21457705 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
rubiadin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calcr calcitonin receptor decreases expression EXP rubiadin results in decreased expression of CALCR mRNA CTD PMID:21945525 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392
JBrowse link
G Car2 carbonic anhydrase 2 decreases expression EXP rubiadin results in decreased expression of CA2 mRNA CTD PMID:21945525 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Ctsk cathepsin K increases activity EXP rubiadin results in increased activity of CTSK protein CTD PMID:21945525 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein] CTD PMID:21945525 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression EXP rubiadin results in increased expression of TNFRSF11B mRNA; rubiadin results in increased expression of TNFRSF11B protein CTD PMID:21945525 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression
multiple interactions
EXP rubiadin results in decreased expression of TNFSF11 mRNA; rubiadin results in decreased expression of TNFSF11 protein
rubiadin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of NFKBIA protein]
CTD PMID:21945525 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      molecular entity 19811
        polyatomic entity 19733
          heteroatomic molecular entity 19674
            hydroxides 19169
              organic hydroxy compound 18662
                phenols 18267
                  hydroxyanthraquinones 480
                    1,3,5,8-Tetrahydroxy-6-methoxy-2-methylanthraquinone 0
                    1,3,5-Trihydroxy-6,7-dimethoxy-2-methylanthraquinone 0
                    Cajaquinone 0
                    Haematommone 0
                    Heliocide B2 0
                    Heliocide H1 0
                    Heliocide H2 0
                    Heliocide H3 0
                    Heliocide H4 0
                    Phomarin 0
                    Rhababerone 0
                    dihydroxyanthraquinone + 337
                    hexahydroxyanthraquinone + 0
                    monohydroxyanthraquinone + 0
                    pentahydroxyanthraquinone + 0
                    tetrahydroxyanthraquinone + 0
                    trihydroxyanthraquinone + 212
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    p-block element atom 19710
                      carbon group element atom 19631
                        carbon atom 19621
                          organic molecular entity 19621
                            organic group 18730
                              organic divalent group 18721
                                organodiyl group 18721
                                  carbonyl group 18670
                                    carbonyl compound 18670
                                      ketone 16930
                                        cyclic ketone 15400
                                          quinone 8387
                                            acenoquinone 7519
                                              anthraquinone 490
                                                hydroxyanthraquinones 480
                                                  1,3,5,8-Tetrahydroxy-6-methoxy-2-methylanthraquinone 0
                                                  1,3,5-Trihydroxy-6,7-dimethoxy-2-methylanthraquinone 0
                                                  Cajaquinone 0
                                                  Haematommone 0
                                                  Heliocide B2 0
                                                  Heliocide H1 0
                                                  Heliocide H2 0
                                                  Heliocide H3 0
                                                  Heliocide H4 0
                                                  Phomarin 0
                                                  Rhababerone 0
                                                  dihydroxyanthraquinone + 337
                                                  hexahydroxyanthraquinone + 0
                                                  monohydroxyanthraquinone + 0
                                                  pentahydroxyanthraquinone + 0
                                                  tetrahydroxyanthraquinone + 0
                                                  trihydroxyanthraquinone + 212
paths to the root