tributylstannane - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	tributylstannane	go back to main search page
Accession:	CHEBI:27086	browse the term
Definition:	An organotin compound that has formula C12H28Sn.
Synonyms:	related_synonym:	Formula=C12H28Sn; InChI=1S/3C4H9.Sn.H/c31-3-4-2;;/h31,3-4H2,2H3;;; InChIKey=DBGVGMSCBYYSLD-UHFFFAOYSA-N; SMILES=[H][Sn](CCCC)(CCCC)CCCC; SnBu3H; TBT; Tri-n-butyltin; Tri-n-butyltin hydride; Tributyltin; [Sn(Bu)3H]
	xref:	Beilstein:3587329; CAS:688-73-3; Gmelin:4258
	xref_mesh:	MESH:C011559
	xref:	UM-BBD_compID:c0579

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Genes (1059)

tributylstannane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 1810010H24 gene

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of C10H17ORF58 mRNA

NCBI chr11:106,913,499...106,921,269
Ensembl chr11:106,916,507...106,921,269

G

RIKEN cDNA 5530400C23 gene

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PRR4 mRNA

NCBI chr 6:133,269,179...133,272,753
Ensembl chr 6:133,269,179...133,272,755

G

alpha-1-B glycoprotein

decreases expression

tributyltin results in decreased expression of A1BG mRNA

NCBI chr15:60,789,438...60,793,119
Ensembl chr15:60,768,708...60,794,861

G

AADACL2 family member 2

increases expression

tributyltin results in increased expression of AADACL2FM2 mRNA

NCBI chr 3:59,637,207...59,659,818
Ensembl chr 3:59,637,211...59,659,754

G

aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of AASDHPPT mRNA

NCBI chr 9:4,294,793...4,309,656
Ensembl chr 9:4,294,793...4,309,471

G

ATP-binding cassette, sub-family A member 1

increases expression
multiple interactions

tributyltin results in increased expression of ABCA1; tributyltin results in increased expression of ABCA1 mRNA
[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA; [tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein; diazepinylbenzoic acid inhibits the reaction [[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]; UVI 3003 inhibits the reaction [tributyltin results in increased expression of ABCA1 mRNA]
diazepinylbenzoic acid inhibits the reaction [tributyltin results in increased expression of ABCA1 mRNA]

PMID:21622945 PMID:23824090 PMID:24356939 PMID:25932594 PMID:31006824

NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895

G

ATP-binding cassette, sub-family B member 1A

decreases expression
increases expression

tributyltin results in decreased expression of ABCB1 protein
tributyltin results in increased expression of ABCB1A mRNA

PMID:26079211 PMID:31939706

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

ATP binding cassette subfamily G member 1

increases expression

tributyltin results in increased expression of ABCG1 mRNA

PMID:23824090 PMID:24356939

NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962

G

acetyl-CoA acyltransferase 2

increases expression

tributyltin results in increased expression of ACAA2 mRNA

NCBI chr18:74,912,283...74,939,278
Ensembl chr18:74,912,268...74,939,279

G

acetyl-Coenzyme A carboxylase alpha

increases expression

tributyltin results in increased expression of ACACA mRNA

NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477

G

acyl-Coenzyme A dehydrogenase, long-chain

increases expression

tributyltin results in increased expression of ACADL mRNA

NCBI chr 1:66,869,998...66,902,468
Ensembl chr 1:66,869,998...66,902,436

G

acyl-Coenzyme A dehydrogenase, medium chain

increases expression

tributyltin results in increased expression of ACADM mRNA

PMID:23428407 PMID:24848799

NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269

G

acyl-Coenzyme A dehydrogenase, very long chain

increases expression

tributyltin results in increased expression of ACADVL mRNA

NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237

G

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ACAP2 mRNA

NCBI chr16:30,911,230...31,020,105
Ensembl chr16:30,911,230...31,020,063

G

acetyl-Coenzyme A acetyltransferase 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ACAT1 mRNA

NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682

G

angiotensin I converting enzyme

increases expression

tributyltin results in increased expression of ACE mRNA

NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790

G

angiotensin converting enzyme 2

increases expression

tributyltin results in increased expression of ACE2 mRNA

NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416

G

aconitase 2, mitochondrial

increases expression

tributyltin results in increased expression of ACO2 mRNA

PMID:23428407 PMID:24848799

NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334

G

acyl-CoA thioesterase 3

increases expression

tributyltin results in increased expression of ACOT3 mRNA

NCBI chr12:84,098,918...84,107,174
Ensembl chr12:84,098,918...84,107,176

G

acyl-Coenzyme A oxidase 1, palmitoyl

increases expression

tributyltin results in increased expression of ACOX1 mRNA

PMID:23322813 PMID:23428407

NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871

G

acyl-Coenzyme A oxidase-like

increases expression

tributyltin results in increased expression of ACOXL mRNA

NCBI chr 2:127,680,717...127,968,172
Ensembl chr 2:127,680,796...127,965,793

G

acyl-CoA synthetase long-chain family member 1

increases expression

tributyltin results in increased expression of ACSL1 mRNA

NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088

G

acyl-CoA synthetase long-chain family member 3

increases expression

tributyltin results in increased expression of ACSL3 mRNA

NCBI chr 1:78,635,600...78,685,462
Ensembl chr 1:78,635,542...78,685,460

G

acyl-CoA synthetase short-chain family member 1

increases expression

tributyltin results in increased expression of ACSS1 mRNA

NCBI chr 2:150,460,031...150,510,160
Ensembl chr 2:150,460,025...150,510,420

G

actin alpha 2, smooth muscle, aorta

increases expression

tributyltin results in increased expression of ACTA2 protein

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

actinin, alpha 1

increases expression

tributyltin results in increased expression of ACTN1 mRNA

NCBI chr12:80,214,316...80,307,165
Ensembl chr12:80,214,321...80,307,145

G

adenosine deaminase

increases expression

tributyltin results in increased expression of ADA mRNA

NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159

G

ADAM metallopeptidase domain 9

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ADAM9 mRNA

NCBI chr 8:25,439,627...25,507,138
Ensembl chr 8:25,439,627...25,506,943

G

ADAM metallopeptidase with thrombospondin type 1 motif 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ADAMTS2 mRNA

NCBI chr11:50,492,912...50,698,400
Ensembl chr11:50,492,911...50,698,400

G

ArfGAP with dual PH domains 1

increases expression

tributyltin results in increased expression of ADAP1 mRNA

NCBI chr 5:139,257,631...139,311,516
Ensembl chr 5:139,257,631...139,311,377

G

adenosine deaminase, RNA-specific, B1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ADARB1 mRNA

NCBI chr10:77,126,561...77,254,125
Ensembl chr10:77,126,560...77,254,104

G

adenylate cyclase 1

decreases expression

tributyltin results in decreased expression of ADCY1 mRNA

NCBI chr11:7,013,433...7,128,506
Ensembl chr11:7,013,489...7,128,506

G

adenylate cyclase 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ADCY2 mRNA; [bisphenol A co-treated with tributyltin] results in increased expression of ADCY2 protein

NCBI chr13:68,768,162...69,147,719
Ensembl chr13:68,768,162...69,147,660

G

adenylate cyclase activating polypeptide 1 receptor 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ADCYAP1R1 mRNA

NCBI chr 6:55,428,486...55,478,440
Ensembl chr 6:55,428,963...55,478,436

G

adiponectin, C1Q and collagen domain containing

multiple interactions
increases expression
decreases secretion
affects expression
decreases expression

[triphenyltin chloride co-treated with tributyltin co-treated with dibutyldichlorotin] affects the expression of ADIPOQ protein; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]
tributyltin results in increased expression of ADIPOQ mRNA; tributyltin results in increased expression of ADIPOQ protein
tributyltin results in decreased secretion of ADIPOQ protein
tributyltin affects the expression of ADIPOQ protein
tributyltin results in decreased expression of ADIPOQ protein
tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased secretion of ADIPOQ protein]; tributyltin promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]

PMID:22197818 PMID:23428407 PMID:28161095 PMID:28397090 PMID:29675927 More...

NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778

G

adiponectin receptor 2

increases expression

tributyltin results in increased expression of ADIPOR2 mRNA

NCBI chr 6:119,330,111...119,394,489
Ensembl chr 6:119,330,111...119,394,665

G

adrenergic receptor, beta 2

decreases expression

tributyltin results in decreased expression of ADRB2 mRNA

NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030

G

alpha fetoprotein

increases expression

tributyltin results in increased expression of AFP mRNA

NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766

G

1-acylglycerol-3-phosphate O-acyltransferase 2

increases expression

tributyltin results in increased expression of AGPAT2 mRNA

NCBI chr 2:26,483,069...26,494,429
Ensembl chr 2:26,483,069...26,494,429

G

1-acylglycerol-3-phosphate O-acyltransferase 3

increases expression

tributyltin results in increased expression of AGPAT3 mRNA

NCBI chr10:78,105,008...78,188,335
Ensembl chr10:78,105,012...78,188,323

G

angiotensinogen

increases expression
decreases expression

tributyltin results in increased expression of AGT mRNA
tributyltin results in decreased expression of AGT protein modified form

PMID:23428407 PMID:30172001

NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445

G

angiotensin II receptor, type 1a

increases expression

tributyltin results in increased expression of AGTR1A protein

NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850

G

angiotensin II receptor, type 2

decreases expression

tributyltin results in decreased expression of AGTR2 protein

NCBI chr X:21,350,863...21,355,072
Ensembl chr X:21,350,783...21,355,403

G

AHNAK nucleoprotein

increases expression

tributyltin results in increased expression of AHNAK mRNA

NCBI chr19:8,966,640...9,054,299
Ensembl chr19:8,966,648...9,054,278

G

aryl-hydrocarbon receptor

decreases expression

tributyltin results in decreased expression of AHR mRNA

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

aryl-hydrocarbon receptor repressor

multiple interactions
decreases expression

tributyltin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA]
tributyltin results in decreased expression of AHRR mRNA

NCBI chr13:74,359,237...74,440,450
Ensembl chr13:74,359,237...74,440,450

G

allograft inflammatory factor 1

multiple interactions
decreases expression

Phycocyanin inhibits the reaction [tributyltin results in decreased expression of AIF1 protein]

NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044

G

apoptosis-inducing factor, mitochondrion-associated 2

increases expression

tributyltin results in increased expression of AIFM2 mRNA

NCBI chr10:61,551,042...61,575,474
Ensembl chr10:61,551,042...61,575,039

G

aldo-keto reductase family 1 member B

increases expression

tributyltin results in increased expression of AKR1B1 mRNA

NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413

G

aldo-keto reductase family 1, member B7

increases expression

tributyltin results in increased expression of AKR1B7 mRNA

NCBI chr 6:34,389,297...34,400,072
Ensembl chr 6:34,389,269...34,400,077

G

thymoma viral proto-oncogene 1

increases phosphorylation
increases expression

tributyltin results in increased phosphorylation of AKT1 protein
tributyltin results in increased expression of AKT1 protein

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

thymoma viral proto-oncogene 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of AKT3 mRNA

NCBI chr 1:176,847,642...177,091,688
Ensembl chr 1:176,847,639...177,085,769

G

aminolevulinic acid synthase 1

increases expression

tributyltin results in increased expression of ALAS1 mRNA

NCBI chr 9:106,110,654...106,125,153
Ensembl chr 9:106,110,654...106,125,853

G

aldehyde dehydrogenase 18 family, member A1

increases expression

tributyltin results in increased expression of ALDH18A1 mRNA

NCBI chr19:40,538,701...40,576,907
Ensembl chr19:40,538,701...40,576,907

G

aldehyde dehydrogenase family 1, subfamily A1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ALDH1A1 mRNA; [bisphenol A co-treated with tributyltin] results in decreased expression of ALDH1A1 protein

NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829

G

aldehyde dehydrogenase 8 family, member A1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ALDH8A1 mRNA

NCBI chr10:21,253,199...21,272,477
Ensembl chr10:21,253,190...21,272,484

G

ALG8 alpha-1,3-glucosyltransferase

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ALG8 mRNA

NCBI chr 7:97,020,774...97,041,366
Ensembl chr 7:97,020,813...97,041,392

G

arachidonate 5-lipoxygenase activating protein

decreases expression
multiple interactions

tributyltin results in decreased expression of ALOX5AP mRNA
[bisphenol A co-treated with tributyltin] results in decreased expression of ALOX5AP mRNA

NCBI chr 5:149,201,814...149,224,963
Ensembl chr 5:149,201,577...149,224,963

G

alkaline phosphatase, liver/bone/kidney

multiple interactions
decreases expression

tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ALPL mRNA]
tributyltin results in decreased expression of ALPL mRNA; tributyltin results in decreased expression of ALPL protein

PMID:22749964 PMID:23322813 PMID:25777084

NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695

G

angiogenin, ribonuclease, RNase A family, 5

decreases expression

tributyltin results in decreased expression of ANG mRNA

NCBI chr14:51,328,607...51,339,462
Ensembl chr14:51,328,607...51,339,466

G

angiopoietin 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ANGPT2 mRNA

NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578

G

angiopoietin-like 4

increases expression

tributyltin results in increased expression of ANGPTL4 mRNA

PMID:21622945 PMID:21683754 PMID:23428407

NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804

G

ankyrin repeat domain 27

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ANKRD27 mRNA

NCBI chr 7:35,285,652...35,338,662
Ensembl chr 7:35,285,669...35,338,651

G

ankyrin repeat domain 37

increases expression

tributyltin results in increased expression of ANKRD37 mRNA

NCBI chr 8:46,449,945...46,452,904
Ensembl chr 8:46,449,939...46,458,744

G

annexin A4

increases expression

tributyltin results in increased expression of ANXA4 mRNA

NCBI chr 6:86,713,822...86,770,616
Ensembl chr 6:86,713,822...86,770,566

G

annexin A5

decreases expression
multiple interactions

tributyltin results in decreased expression of ANXA5 protein
Tretinoin promotes the reaction [tributyltin results in decreased expression of ANXA5 protein]

NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043

G

adaptor protein complex AP-1, mu 2 subunit

increases expression

tributyltin results in increased expression of AP1M2 mRNA

NCBI chr 9:21,206,753...21,223,617
Ensembl chr 9:21,205,571...21,223,633

G

adaptor-related protein complex 3, sigma 2 subunit

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of AP3S2 mRNA

NCBI chr 7:79,525,073...79,570,388
Ensembl chr 7:79,525,073...79,570,397

G

apolipoprotein C-I

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of APOC1 mRNA

NCBI chr 7:19,423,405...19,426,584
Ensembl chr 7:19,423,406...19,426,585

G

apolipoprotein E

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of APOE mRNA

NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113

G

androgen receptor

multiple interactions

tributyltin inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]

NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821

G

Rho GTPase activating protein 36

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ARHGAP36 mRNA

NCBI chr X:48,537,237...48,589,121
Ensembl chr X:48,552,822...48,589,121

G

Rho guanine nucleotide exchange factor 16

increases expression

tributyltin results in increased expression of ARHGEF16 mRNA

NCBI chr 4:154,362,926...154,384,535
Ensembl chr 4:154,362,943...154,386,133

G

ADP-ribosyltransferase 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ART3 mRNA

NCBI chr 5:92,479,659...92,562,487
Ensembl chr 5:92,479,686...92,562,487

G

adipocyte-related X-chromosome expressed sequence 2

increases expression

tributyltin results in increased expression of ARXES2 mRNA

NCBI chr X:134,894,569...134,896,108
Ensembl chr X:134,894,573...134,896,104

G

ankyrin repeat and SOCS box-containing 10

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ASB10 mRNA

NCBI chr 5:24,737,695...24,745,976
Ensembl chr 5:24,737,695...24,745,976

G

achaete-scute family bHLH transcription factor 1

multiple interactions

[tributyltin co-treated with LHB protein] results in increased expression of ASCL1 mRNA

NCBI chr10:87,326,681...87,329,522
Ensembl chr10:87,326,681...87,329,522

G

achaete-scute family bHLH transcription factor 2

affects expression

tributyltin affects the expression of ASCL2 mRNA

NCBI chr 7:142,520,559...142,523,001
Ensembl chr 7:142,520,566...142,523,001

G

asialoglycoprotein receptor 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ASGR1 mRNA

NCBI chr11:69,939,735...69,948,721
Ensembl chr11:69,944,911...69,948,720

G

asparagine synthetase

increases expression

tributyltin results in increased expression of ASNS mRNA

NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254

G

aspartoacylase

increases expression

tributyltin results in increased expression of ASPA mRNA

NCBI chr11:73,195,813...73,217,677
Ensembl chr11:73,195,818...73,220,422

G

asporin

increases expression

tributyltin results in increased expression of ASPN mRNA

NCBI chr13:49,697,919...49,721,041
Ensembl chr13:49,697,919...49,721,041

G

astacin like metalloendopeptidase

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ASTL mRNA

NCBI chr 2:127,180,559...127,199,575
Ensembl chr 2:127,180,559...127,199,571

G

ATPase family, AAA domain containing 5

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ATAD5 mRNA

NCBI chr11:79,980,205...80,026,623
Ensembl chr11:79,980,226...80,026,620

G

activating transcription factor 2

increases phosphorylation

tributyltin results in increased phosphorylation of ATF2 protein

NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983

G

activating transcription factor 3

increases expression

tributyltin results in increased expression of ATF3 mRNA

NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236

G

activating transcription factor 6

increases cleavage

tributyltin results in increased cleavage of ATF6 protein

NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340

G

ataxia telangiectasia mutated

increases phosphorylation
multiple interactions

tributyltin results in increased phosphorylation of ATM protein
2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased phosphorylation of ATM protein]

NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040

G

ATPase, class VI, type 11A

decreases expression

tributyltin results in decreased expression of ATP11A mRNA

NCBI chr 8:12,807,016...12,918,728
Ensembl chr 8:12,807,014...12,918,728

G

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

decreases expression

tributyltin results in decreased expression of ATP2A2 protein

NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288

G

UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of B3GALNT1 mRNA

NCBI chr 3:69,481,252...69,506,305
Ensembl chr 3:69,481,491...69,506,293

G

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1

decreases expression

tributyltin results in decreased expression of B3GALT1 mRNA

NCBI chr 2:67,395,528...67,953,226
Ensembl chr 2:67,396,215...67,953,033

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

increases expression

tributyltin results in increased expression of B3GNT3 mRNA

NCBI chr 8:72,144,017...72,155,270
Ensembl chr 8:72,143,400...72,154,433

G

BCL2-associated agonist of cell death

multiple interactions

PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BAD protein modified form]

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

BCL2-associated athanogene 3

affects expression

tributyltin affects the expression of BAG3 mRNA

NCBI chr 7:128,125,307...128,148,705
Ensembl chr 7:128,125,340...128,148,705

G

BAI1-associated protein 2-like 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of BAIAP2L1 mRNA

NCBI chr 5:144,201,335...144,294,922
Ensembl chr 5:144,201,336...144,294,922

G

BCL2-associated X protein

affects expression
increases expression
multiple interactions

tributyltin affects the expression of BAX protein
tributyltin results in increased expression of BAX protein
Phycocyanin inhibits the reaction [tributyltin results in increased expression of BAX protein]
PRKCD gene mutant form inhibits the reaction [tributyltin results in increased expression of BAX protein]

PMID:22223438 PMID:23743147 PMID:25895139 PMID:26079211 PMID:28707438

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

bromodomain adjacent to zinc finger domain, 2A

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of BAZ2A mRNA

NCBI chr10:127,927,453...127,965,172
Ensembl chr10:127,927,446...127,965,172

G

BBSome interacting protein 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of BBIP1 mRNA

NCBI chr19:53,918,087...53,933,058
Ensembl chr19:53,918,292...53,933,058

G

Bardet-Biedl syndrome 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of BBS2 mRNA

NCBI chr 8:94,794,580...94,825,997
Ensembl chr 8:94,794,582...94,825,556

G

branched chain aminotransferase 1, cytosolic

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of BCAT1 mRNA

NCBI chr 6:144,939,561...145,021,883
Ensembl chr 6:144,939,561...145,021,910

G

B cell leukemia/lymphoma 2

affects expression
decreases expression
multiple interactions

tributyltin affects the expression of BCL2 protein
tributyltin results in decreased expression of BCL2 protein
Acetylcysteine inhibits the reaction [tributyltin results in decreased expression of BCL2 protein]
PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BCL2 protein]

PMID:22223438 PMID:23743147 PMID:25743928 PMID:25895139 PMID:26079211 More...

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

multiple interactions

PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BCL2L1 protein]

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

bradykinin receptor, beta 1

decreases expression

tributyltin results in decreased expression of BDKRB1 mRNA

NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687

G

beclin 1, autophagy related

decreases expression

tributyltin results in decreased expression of BECN1 protein

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

bone gamma carboxyglutamate protein

multiple interactions
increases expression

tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of BGLAP mRNA]
tributyltin results in increased expression of BGLAP mRNA
tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]

PMID:22749964 PMID:25932594

NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771

G

biglycan

increases expression

tributyltin results in increased expression of BGN mRNA

NCBI chr X:72,527,207...72,539,542
Ensembl chr X:72,527,208...72,539,539

G

basic helix-loop-helix family, member e41

increases expression

tributyltin results in increased expression of BHLHE41 mRNA

NCBI chr 6:145,803,969...145,811,146
Ensembl chr 6:145,803,969...145,811,284

G

BicC family RNA binding protein 1

decreases expression

tributyltin results in decreased expression of BICC1 mRNA

NCBI chr10:70,758,660...70,995,581
Ensembl chr10:70,758,662...70,995,530

G

baculoviral IAP repeat-containing 2

decreases expression

tributyltin results in decreased expression of BIRC2 mRNA

NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065

G

baculoviral IAP repeat-containing 3

decreases expression

tributyltin results in decreased expression of BIRC3 mRNA

NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187

G

basic helix-loop-helix ARNT like 1

decreases expression

tributyltin results in decreased expression of BMAL1 mRNA

NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333

G

BCL2 modifying factor

increases expression

tributyltin results in increased expression of BMF mRNA

NCBI chr 2:118,359,238...118,385,240
Ensembl chr 2:118,359,238...118,380,168

G

bone morphogenetic protein receptor, type 1B

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of BMPR1B mRNA

NCBI chr 3:141,540,230...141,875,335
Ensembl chr 3:141,542,897...141,875,186

G

BCL2 interacting protein 5

increases expression

tributyltin results in increased expression of BNIP5 mRNA

NCBI chr17:29,114,248...29,134,310
Ensembl chr17:29,115,366...29,134,298

G

biorientation of chromosomes in cell division 1-like

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of BOD1L1 mRNA

NCBI chr 5:41,944,881...42,001,695
Ensembl chr 5:41,944,881...42,001,658

G

bromodomain containing 9

increases expression

tributyltin results in increased expression of BRD9 mRNA

NCBI chr13:74,085,920...74,109,014
Ensembl chr13:74,085,930...74,109,014

G

bassoon

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of BSN mRNA

NCBI chr 9:107,973,221...108,067,618
Ensembl chr 9:107,973,221...108,067,583

G

B-box and SPRY domain containing

increases expression

tributyltin results in increased expression of BSPRY mRNA

NCBI chr 4:62,398,248...62,415,537
Ensembl chr 4:62,398,290...62,415,535

G

BTG anti-proliferation factor 2

decreases expression

tributyltin results in decreased expression of BTG2 mRNA

NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858

G

core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1

decreases expression

tributyltin results in decreased expression of C1GALT1 mRNA

NCBI chr 6:7,845,224...7,872,042
Ensembl chr 6:7,844,842...7,875,687

G

complement component 1, r subcomponent-like

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of C1RL mRNA

NCBI chr 6:124,470,072...124,487,602
Ensembl chr 6:124,470,072...124,487,602

G

complement component 8, gamma polypeptide

multiple interactions
affects binding

tributyltin inhibits the reaction [triphenyltin binds to C8G protein]
tributyltin binds to C8G protein

NCBI chr 2:25,388,662...25,391,731
Ensembl chr 2:25,388,663...25,391,731

G

calcium channel, voltage-dependent, T type, alpha 1H subunit

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CACNA1H mRNA

NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759

G

Ca2+-dependent activator protein for secretion 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CADPS2 mRNA

NCBI chr 6:23,262,765...23,840,662
Ensembl chr 6:23,262,772...23,839,420

G

calmodulin 1

multiple interactions

CALM1 protein inhibits the reaction [tributyltin results in decreased activity of NOS1 protein]; tributyltin inhibits the reaction [CALM1 protein binds to NOS1 protein]

NCBI chr12:100,165,694...100,176,083
Ensembl chr12:100,165,694...100,176,073

G

calmodulin-like 4

increases expression

tributyltin results in increased expression of CALML4 mRNA

NCBI chr 9:62,765,068...62,783,203
Ensembl chr 9:62,765,362...62,783,203

G

calreticulin 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CALR3 mRNA

NCBI chr 8:73,178,020...73,197,638
Ensembl chr 8:73,178,020...73,197,714

G

calcium/calmodulin-dependent protein kinase II, beta

increases activity
decreases expression
multiple interactions

tributyltin results in increased activity of CAMK2B protein
tributyltin results in decreased expression of CAMK2B mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of CAMK2B mRNA

PMID:20810541 PMID:31129395

NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362

G

calcium/calmodulin-dependent protein kinase II, delta

increases activity

tributyltin results in increased activity of CAMK2D protein

NCBI chr 3:126,389,136...126,639,975
Ensembl chr 3:126,389,951...126,639,975

G

calcium/calmodulin-dependent protein kinase II gamma

increases activity

tributyltin results in increased activity of CAMK2G protein

NCBI chr14:20,784,943...20,844,225
Ensembl chr14:20,784,943...20,844,156

G

calmodulin binding transcription activator 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CAMTA1 mRNA

NCBI chr 4:151,143,980...151,946,225
Ensembl chr 4:151,143,982...151,946,333

G

calpain 12

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CAPN12 mRNA

NCBI chr 7:28,580,890...28,593,010
Ensembl chr 7:28,580,847...28,592,988

G

carbonic anhydrase 13

increases expression

tributyltin results in increased expression of CAR13 mRNA

NCBI chr 3:14,706,787...14,728,062
Ensembl chr 3:14,706,787...14,728,062

G

carbonic anhydrase 14

increases expression

tributyltin results in increased expression of CAR14 mRNA

NCBI chr 3:95,805,080...95,812,443
Ensembl chr 3:95,805,080...95,812,003

G

carbonic anhydrase 9

increases expression

tributyltin results in increased expression of CAR9 mRNA

NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729

G

caspase 12

increases expression

tributyltin results in increased expression of CASP12 protein

NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032

G

caspase 3

multiple interactions
increases activity
increases expression
increases cleavage
decreases expression

Acetylcysteine inhibits the reaction [tributyltin results in increased expression of CASP3 protein modified form]; Phycocyanin inhibits the reaction [tributyltin results in increased activity of CASP3 protein]; Phycocyanin inhibits the reaction [tributyltin results in increased expression of CASP3 protein modified form]; SB 203580 inhibits the reaction [tributyltin results in increased expression of CASP3 protein]; tributyltin results in increased expression of and results in increased cleavage of CASP3 protein
tributyltin results in increased expression of CASP3 protein; tributyltin results in increased expression of CASP3 protein modified form
tributyltin results in increased cleavage of CASP3 protein
PRKCD gene mutant form inhibits the reaction [tributyltin results in increased expression of CASP3 protein modified form]
tributyltin results in decreased expression of CASP3 protein
DFFB protein promotes the reaction [tributyltin results in decreased expression of CASP3 protein]

PMID:17341481 PMID:21477642 PMID:21626652 PMID:21683754 PMID:22223438 More...

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 6

multiple interactions
decreases expression

DFFB protein promotes the reaction [tributyltin results in decreased expression of CASP6 protein]

NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752

G

caspase 7

increases activity

tributyltin results in increased activity of CASP7 protein

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

caspase 8

increases expression
decreases expression

tributyltin results in increased expression of CASP8 protein
tributyltin results in decreased expression of CASP8 protein

PMID:23743147 PMID:28707438

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CASP9 mRNA

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

calpastatin

multiple interactions

CAST protein inhibits the reaction [tributyltin results in increased degradation of MAPT protein]; CAST protein inhibits the reaction [tributyltin results in increased degradation of NEFM protein]; CAST protein inhibits the reaction [tributyltin results in increased degradation of TUBB3 protein]

NCBI chr13:74,840,485...74,956,993
Ensembl chr13:74,840,487...74,956,929

G

castor zinc finger 1

increases expression

tributyltin results in increased expression of CASZ1 mRNA

NCBI chr 4:148,888,823...149,039,350
Ensembl chr 4:148,888,886...149,039,346

G

catalase

multiple interactions
increases expression
decreases activity

[bisphenol A co-treated with tributyltin] results in increased expression of CAT mRNA; Acetylcysteine inhibits the reaction [tributyltin results in increased expression of CAT protein]
tributyltin results in decreased activity of CAT protein

PMID:26079211 PMID:26873547 PMID:31129395 PMID:33720505 PMID:34902535

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cerebellin 1 precursor protein

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CBLN1 mRNA

NCBI chr 8:88,195,481...88,199,220
Ensembl chr 8:88,195,033...88,199,237

G

coiled-coil domain containing 125

decreases expression

tributyltin results in decreased expression of CCDC125 mRNA

NCBI chr13:100,805,442...100,833,748
Ensembl chr13:100,806,225...100,833,748

G

coiled-coil domain containing 159

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CCDC159 mRNA

NCBI chr 9:21,838,767...21,847,168
Ensembl chr 9:21,838,767...21,847,168

G

C-C motif chemokine ligand 2

increases expression

tributyltin results in increased expression of CCL2 mRNA

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 25

increases expression

tributyltin results in increased expression of CCL25 mRNA

NCBI chr 8:4,375,207...4,410,020
Ensembl chr 8:4,375,210...4,410,020

G

C-C motif chemokine ligand 5

multiple interactions

[tributyltin co-treated with LHB protein] results in decreased secretion of CCL5 protein

NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344

G

C-C motif chemokine ligand 7

decreases expression

tributyltin results in decreased expression of CCL7 mRNA

NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351

G

C-C motif chemokine ligand 8

multiple interactions

[tributyltin co-treated with LHB protein] results in decreased secretion of CCL8 protein

NCBI chr11:82,006,011...82,007,625
Ensembl chr11:82,006,011...82,007,625

G

cyclin B1

multiple interactions
decreases expression

dimethyl alpha-ketoglutarate inhibits the reaction [tributyltin results in decreased expression of CCNB1 protein]; IDH3A protein affects the reaction [tributyltin results in decreased expression of CCNB1 protein]

NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078

G

C-C motif chemokine receptor 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CCR1 mRNA

NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729

G

C-C motif chemokine receptor 7

increases expression

tributyltin results in increased expression of CCR7 mRNA

NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903

G

chaperonin containing TCP1 subunit 7

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CCT7 mRNA

NCBI chr 6:85,428,487...85,445,459
Ensembl chr 6:85,428,496...85,445,457

G

CD22 antigen

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CD22 mRNA

NCBI chr 7:30,564,829...30,579,767
Ensembl chr 7:30,564,827...30,579,767

G

CD300 molecule like family member F

increases expression

tributyltin results in increased expression of CD300LF mRNA

NCBI chr11:115,007,040...115,024,834
Ensembl chr11:115,007,040...115,024,818

G

CD36 molecule

increases expression

tributyltin results in increased expression of CD36 mRNA

PMID:23428407 PMID:24848799

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

G

CD68 antigen

increases expression

tributyltin results in increased expression of CD68 protein

NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979

G

CD83 antigen

increases expression

tributyltin results in increased expression of CD83 mRNA

NCBI chr13:43,938,661...43,956,608
Ensembl chr13:43,938,251...43,956,608

G

CDC14 cell division cycle 14A

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CDC14A mRNA

NCBI chr 3:116,066,202...116,222,390
Ensembl chr 3:116,066,202...116,222,394

G

cell division cycle 25C

decreases expression
multiple interactions

tributyltin results in decreased expression of CDC25C protein
dimethyl alpha-ketoglutarate inhibits the reaction [tributyltin results in decreased expression of CDC25C protein]; IDH3A protein affects the reaction [tributyltin results in decreased expression of CDC25C protein]

NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586

G

cell division cycle associated 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CDCA3 mRNA

NCBI chr 6:124,806,533...124,810,664
Ensembl chr 6:124,806,510...124,810,664

G

cadherin 9

decreases expression

tributyltin results in decreased expression of CDH9 mRNA

NCBI chr15:16,728,641...16,857,224
Ensembl chr15:16,728,842...16,857,180

G

cadherin-related family member 2

increases expression

tributyltin results in increased expression of CDHR2 mRNA

NCBI chr13:54,849,276...54,884,475
Ensembl chr13:54,849,274...54,884,475

G

cell death inducing Trp53 target 1

increases expression

tributyltin results in increased expression of CDIP1 mRNA

NCBI chr16:4,583,325...4,608,156
Ensembl chr16:4,568,212...4,608,156

G

cyclin dependent kinase 13

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CDK13 mRNA

NCBI chr13:17,885,309...17,979,960
Ensembl chr13:17,884,900...17,979,682

G

cyclin dependent kinase 5, regulatory subunit 1

decreases expression

tributyltin results in decreased expression of CDK5R1 mRNA

NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010

G

cyclin dependent kinase inhibitor 1A

increases expression
decreases expression
multiple interactions

tributyltin results in increased expression of CDKN1A mRNA; tributyltin results in increased expression of CDKN1A protein
tributyltin results in decreased expression of CDKN1A mRNA
2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased expression of CDKN1A protein]; pyrazolanthrone inhibits the reaction [tributyltin results in increased expression of CDKN1A protein]

PMID:28011154 PMID:31939706 PMID:36319700

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cyclin dependent kinase inhibitor 1B

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CDKN1B mRNA

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

cyclin dependent kinase inhibitor 2B

multiple interactions

2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased expression of CDKN2B protein]

NCBI chr 4:89,224,526...89,229,269
Ensembl chr 4:89,224,536...89,229,276

G

cerebellar degeneration-related 2

increases expression

tributyltin results in increased expression of CDR2 mRNA

NCBI chr 7:120,556,259...120,581,535
Ensembl chr 7:120,556,259...120,581,535

G

chromodomain protein, Y chromosome-like

increases expression

tributyltin results in increased expression of CDYL mRNA

NCBI chr13:35,843,801...36,058,047
Ensembl chr13:35,843,816...36,058,046

G

CCAAT/enhancer binding protein alpha

increases expression
multiple interactions

tributyltin results in increased expression of CEBPA mRNA
T 0070907 inhibits the reaction [tributyltin results in increased expression of CEBPA mRNA]

PMID:25932594 PMID:28011154 PMID:29787037

NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353

G

CCAAT/enhancer binding protein beta

increases expression

tributyltin results in increased expression of CEBPB mRNA

PMID:21683754 PMID:29908848

NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338

G

CUGBP, Elav-like family member 2

decreases expression

tributyltin results in decreased expression of CELF2 mRNA

NCBI chr 2:6,544,505...7,401,345
Ensembl chr 2:6,544,505...7,514,374

G

centrosomal protein 19

increases expression

tributyltin results in increased expression of CEP19 mRNA

NCBI chr16:31,918,618...31,926,875
Ensembl chr16:31,918,618...31,926,887

G

centrosomal protein 76

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CEP76 mRNA

NCBI chr18:67,750,034...67,774,425
Ensembl chr18:67,750,870...67,774,406

G

carboxylesterase 1D

increases expression

tributyltin results in increased expression of CES1D mRNA

NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466

G

cilia and flagella associated protein 210

decreases expression

tributyltin results in decreased expression of CFAP210 mRNA

NCBI chr 2:69,587,736...69,619,873
Ensembl chr 2:69,588,377...69,619,919

G

cilia and flagella associated protein 53

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CFAP53 mRNA

NCBI chr18:74,416,171...74,493,055
Ensembl chr18:74,416,161...74,493,057

G

complement factor D

increases expression

tributyltin results in increased expression of CFD mRNA

NCBI chr10:79,726,687...79,728,489
Ensembl chr10:79,726,687...79,728,489

G

cystic fibrosis transmembrane conductance regulator

increases expression

tributyltin results in increased expression of CFTR mRNA

NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767

G

ChaC, cation transport regulator 1

decreases expression

tributyltin results in decreased expression of CHAC1 mRNA

NCBI chr 2:119,181,723...119,184,807
Ensembl chr 2:119,181,710...119,184,862

G

choline O-acetyltransferase

decreases activity

tributyltin results in decreased activity of CHAT protein

NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946

G

chromodomain helicase DNA binding protein 9

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CHD9 mRNA

NCBI chr 8:91,554,930...91,781,144
Ensembl chr 8:91,554,980...91,781,144

G

chitinase 3 like 1

increases expression

tributyltin results in increased expression of CHI3L1 mRNA

NCBI chr 1:134,109,894...134,117,769
Ensembl chr 1:134,109,914...134,117,919

G

choline kinase alpha

decreases expression

tributyltin results in decreased expression of CHKA mRNA

NCBI chr19:3,901,585...3,944,368
Ensembl chr19:3,901,773...3,944,369

G

charged multivesicular body protein 4C

increases expression

tributyltin results in increased expression of CHMP4C mRNA

NCBI chr 3:10,432,033...10,456,065
Ensembl chr 3:10,431,967...10,493,916

G

calcineurin-like EF hand protein 2

increases expression

tributyltin results in increased expression of CHP2 mRNA

NCBI chr 7:121,807,839...121,823,094
Ensembl chr 7:121,818,719...121,822,047

G

circadian associated repressor of transcription

increases expression

tributyltin results in increased expression of CIART mRNA

NCBI chr 3:95,785,812...95,790,012
Ensembl chr 3:95,785,815...95,789,563

G

CBY1 interacting BAR domain containing 1

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of CIBAR1 mRNA
tributyltin results in increased expression of CIBAR1 mRNA

NCBI chr 4:12,153,142...12,172,047
Ensembl chr 4:12,153,409...12,172,015

G

cell death-inducing DNA fragmentation factor, alpha subunit-like effector A

increases expression

tributyltin results in increased expression of CIDEA mRNA

NCBI chr18:67,476,634...67,500,864
Ensembl chr18:67,476,674...67,500,855

G

cell death-inducing DFFA-like effector c

increases expression
multiple interactions

tributyltin results in increased expression of CIDEC mRNA
T 0070907 inhibits the reaction [tributyltin results in increased expression of CIDEC mRNA]

PMID:23322813 PMID:29787037

NCBI chr 6:113,401,595...113,412,721
Ensembl chr 6:113,401,595...113,412,721

G

creatine kinase, brain

increases expression

tributyltin results in increased expression of CKB mRNA

NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772

G

claudin 14

decreases expression

tributyltin results in decreased expression of CLDN14 mRNA

NCBI chr16:93,715,919...93,809,733
Ensembl chr16:93,715,919...93,809,696

G

claudin 15

increases expression

tributyltin results in increased expression of CLDN15 mRNA

NCBI chr 5:136,996,723...137,004,699
Ensembl chr 5:136,995,470...137,004,712

G

claudin 16

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CLDN16 mRNA

NCBI chr16:26,281,885...26,301,515
Ensembl chr16:26,281,885...26,301,515

G

claudin 4

increases expression

tributyltin results in increased expression of CLDN4 mRNA

NCBI chr 5:134,973,977...134,975,788
Ensembl chr 5:134,973,973...134,975,788

G

claudin 5

multiple interactions
decreases expression

Phycocyanin inhibits the reaction [tributyltin results in decreased expression of CLDN5 protein]

NCBI chr16:18,595,597...18,597,012
Ensembl chr16:18,595,597...18,597,012

G

claudin 7

increases expression

tributyltin results in increased expression of CLDN7 mRNA

NCBI chr11:69,855,605...69,858,712
Ensembl chr11:69,855,605...69,858,711

G

C-type lectin domain family 2, member h

increases expression

tributyltin results in increased expression of CLEC2H mRNA

NCBI chr 6:128,639,348...128,654,337
Ensembl chr 6:128,639,348...128,654,337

G

chloride intracellular channel 4

increases expression

tributyltin results in increased expression of CLIC4 mRNA

NCBI chr 4:134,941,280...135,000,071
Ensembl chr 4:134,941,280...135,000,125

G

chloride intracellular channel 5

increases expression

tributyltin results in increased expression of CLIC5 mRNA

NCBI chr17:44,445,671...44,591,059
Ensembl chr17:44,445,659...44,591,059

G

caseinolytic mitochondrial matrix peptidase chaperone subunit

decreases expression

tributyltin results in decreased expression of CLPX mRNA

NCBI chr 9:65,201,533...65,237,940
Ensembl chr 9:65,201,542...65,237,940

G

calsyntenin 3

increases expression

tributyltin results in increased expression of CLSTN3 mRNA

NCBI chr 6:124,407,715...124,441,743
Ensembl chr 6:124,407,540...124,441,753

G

cytidine monophospho-N-acetylneuraminic acid synthetase

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CMAS mRNA

NCBI chr 6:142,702,468...142,721,440
Ensembl chr 6:142,702,412...142,721,440

G

2',3'-cyclic nucleotide 3' phosphodiesterase

increases expression

tributyltin results in increased expression of CNP mRNA

NCBI chr11:100,465,765...100,472,565
Ensembl chr11:100,465,730...100,482,555

G

collagen, type I, alpha 1

increases expression

tributyltin results in increased expression of COL1A1 mRNA

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type I, alpha 2

increases expression

tributyltin results in increased expression of COL1A2 mRNA

NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544

G

collagen, type II, alpha 1

decreases expression

tributyltin results in decreased expression of COL2A1 mRNA

NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576

G

collagen, type VI, alpha 1

increases expression

tributyltin results in increased expression of COL6A1 mRNA

NCBI chr10:76,544,626...76,561,869
Ensembl chr10:76,544,626...76,562,002

G

collagen, type VI, alpha 3

increases expression

tributyltin results in increased expression of COL6A3 mRNA

NCBI chr 1:90,694,582...90,771,710
Ensembl chr 1:90,693,645...90,771,693

G

collagen, type VII, alpha 1

multiple interactions
decreases expression

Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of COL7A1 mRNA]

NCBI chr 9:108,782,654...108,813,943
Ensembl chr 9:108,782,654...108,813,943

G

collagen, type IX, alpha 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of COL9A3 mRNA

NCBI chr 2:180,239,895...180,263,985
Ensembl chr 2:180,239,583...180,263,982

G

COMM domain containing 9

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of COMMD9 mRNA

NCBI chr 2:101,716,607...101,731,984
Ensembl chr 2:101,716,592...101,731,991

G

coronin, actin binding protein 2A

increases expression

tributyltin results in increased expression of CORO2A mRNA

NCBI chr 4:46,536,937...46,601,929
Ensembl chr 4:46,536,937...46,602,202

G

cytochrome c oxidase subunit 7A1

increases expression

tributyltin results in increased expression of COX7A1 mRNA

PMID:24848799 PMID:31939706

NCBI chr 7:29,883,596...29,885,455
Ensembl chr 7:29,883,569...29,885,503

G

cytochrome c oxidase subunit 7A2 like

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of COX7A2L mRNA

NCBI chr17:83,809,346...83,821,762
Ensembl chr17:83,809,347...83,824,759

G

cytochrome c oxidase subunit 8B

increases expression

tributyltin results in increased expression of COX8B mRNA

NCBI chr 7:140,478,855...140,480,359
Ensembl chr 7:140,478,858...140,480,359

G

complexin 3

increases expression

tributyltin results in increased expression of CPLX3 mRNA

NCBI chr 9:57,507,275...57,513,564
Ensembl chr 9:57,507,275...57,513,564

G

copine IV

decreases expression

tributyltin results in decreased expression of CPNE4 mRNA

NCBI chr 9:104,443,900...104,911,747
Ensembl chr 9:104,424,485...104,911,743

G

carnitine palmitoyltransferase 1a, liver

increases expression

tributyltin results in increased expression of CPT1A mRNA

NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733

G

carnitine palmitoyltransferase 2

increases expression

tributyltin results in increased expression of CPT2 mRNA

NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807

G

cellular retinoic acid binding protein I

decreases expression

tributyltin results in decreased expression of CRABP1 mRNA

NCBI chr 9:54,672,032...54,680,394
Ensembl chr 9:54,672,032...54,680,394

G

cellular retinoic acid binding protein II

increases expression

tributyltin results in increased expression of CRABP2 mRNA

NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683

G

cysteine-rich with EGF-like domains 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CRELD1 mRNA

NCBI chr 6:113,460,317...113,470,304
Ensembl chr 6:113,460,258...113,470,304

G

cAMP responsive element modulator

increases expression

tributyltin results in increased expression of CREM mRNA

NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748

G

cysteine-rich protein 1

increases expression

tributyltin results in increased expression of CRIP1 mRNA

NCBI chr12:113,115,632...113,117,499
Ensembl chr12:113,109,936...113,117,499

G

cytokine receptor-like factor 1

increases expression

tributyltin results in increased expression of CRLF1 mRNA

NCBI chr 8:70,945,798...70,956,728
Ensembl chr 8:70,945,808...70,956,731

G

cartilage acidic protein 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CRTAC1 mRNA

NCBI chr19:42,271,474...42,421,405
Ensembl chr19:42,256,726...42,420,224

G

colony stimulating factor 3 (granulocyte)

multiple interactions
increases expression

Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in increased expression of CSF3 mRNA]

NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455

G

citrate synthase like

increases expression

tributyltin results in increased expression of CSL mRNA

NCBI chr10:99,593,567...99,595,346
Ensembl chr10:99,593,568...99,595,520

G

cleavage stimulation factor, 3' pre-RNA, subunit 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CSTF1 mRNA

NCBI chr 2:172,212,591...172,224,369
Ensembl chr 2:172,212,601...172,224,368

G

catenin alpha 1

increases expression

tributyltin results in increased expression of CTNNA1 mRNA

NCBI chr18:35,251,955...35,387,829
Ensembl chr18:35,251,912...35,387,832

G

catenin beta 1

increases expression

tributyltin results in increased expression of CTNNB1 mRNA

NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573

G

cathepsin K

multiple interactions
decreases expression

Tetrachlorodibenzodioxin inhibits the reaction [tributyltin results in decreased expression of CTSK mRNA]

NCBI chr 3:95,406,521...95,416,698
Ensembl chr 3:95,406,567...95,416,673

G

C-X3-C motif chemokine ligand 1

increases expression

tributyltin results in increased expression of CX3CL1 mRNA

NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055

G

C-X-C motif chemokine ligand 13

multiple interactions

[tributyltin co-treated with LHB protein] results in decreased secretion of CXCL13 protein

NCBI chr 5:96,104,785...96,108,927
Ensembl chr 5:96,104,810...96,108,927

G

C-X-C motif chemokine ligand 14

increases expression

tributyltin results in increased expression of CXCL14 mRNA

NCBI chr13:56,436,456...56,444,624
Ensembl chr13:56,436,456...56,444,364

G

C-X-C motif chemokine ligand 15

decreases expression

tributyltin results in decreased expression of CXCL8 mRNA

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

C-X-C motif chemokine ligand 3

decreases expression

tributyltin results in decreased expression of CXCL1 mRNA

NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459

G

C-X-C motif chemokine receptor 2

decreases expression

tributyltin results in decreased expression of CXCR2 mRNA

NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405

G

C-X-C motif chemokine receptor 4

increases expression

tributyltin results in increased expression of CXCR4 mRNA

PMID:19371601 PMID:26314263

NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030

G

cytochrome b5 type A (microsomal)

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of CYB5A mRNA

NCBI chr18:84,869,463...84,897,996
Ensembl chr18:84,856,829...84,897,996

G

cytochrome b-245, beta polypeptide

increases expression

tributyltin results in increased expression of CYBB protein

NCBI chr X:9,301,493...9,354,005
Ensembl chr X:9,301,491...9,354,010

G

cytochrome c, somatic

increases expression

tributyltin results in increased expression of CYCS mRNA

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

cytochrome P450, family 11, subfamily a, polypeptide 1

increases expression

tributyltin results in increased expression of CYP11A1 protein

NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306

G

cytochrome P450, family 11, subfamily b, polypeptide 2

increases expression
multiple interactions

tributyltin results in increased expression of CYP11B2 mRNA
[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B2 mRNA

PMID:25765474 PMID:29549738

NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,467...74,728,167

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression

tributyltin results in decreased expression of CYP17A1 mRNA; tributyltin results in decreased expression of CYP17A1 protein

NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
decreases activity
increases activity
increases expression
decreases expression

[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP19A1 mRNA; [tributyltin binds to and results in increased activity of RXRA protein] which results in increased expression of CYP19A1 protein; [tributyltin co-treated with Testosterone] results in increased expression of CYP19A1 mRNA; Finasteride promotes the reaction [[tributyltin co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]; tributyltin inhibits the reaction [CYP19A1 protein affects the metabolism of Testosterone]; tributyltin inhibits the reaction [CYP19A1 protein binds to and results in increased metabolism of Androstenedione]; tributyltin promotes the reaction [[Finasteride co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]
tributyltin results in decreased activity of CYP19A1 protein
tributyltin results in increased activity of CYP19A1 protein
tributyltin results in increased expression of CYP19A1 mRNA; tributyltin results in increased expression of CYP19A1 protein
tributyltin results in decreased expression of CYP19A1 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of CYP19A1 protein

PMID:11522339 PMID:11751016 PMID:15941851 PMID:16996190 PMID:18310892 More...

NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP1A1 mRNA

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 21, subfamily a, polypeptide 1

decreases expression

tributyltin results in decreased expression of CYP21A2 mRNA

NCBI chr17:35,020,322...35,023,400
Ensembl chr17:35,020,322...35,023,535

G

cytochrome P450, family 26, subfamily a, polypeptide 1

increases expression

tributyltin results in increased expression of CYP26A1 mRNA

NCBI chr19:37,686,186...37,689,984
Ensembl chr19:37,686,246...37,689,984

G

cytochrome P450, family 2, subfamily c, polypeptide 69

decreases expression

tributyltin results in decreased expression of CYP2C69 mRNA

NCBI chr19:39,831,104...39,875,213
Ensembl chr19:39,831,258...39,875,243

G

cytochrome P450, family 2, subfamily s, polypeptide 1

increases expression

tributyltin results in increased expression of CYP2S1 mRNA

NCBI chr 7:25,501,894...25,515,950
Ensembl chr 7:25,501,900...25,516,338

G

cytochrome P450, family 7, subfamily a, polypeptide 1

increases expression

tributyltin results in increased expression of CYP7A1 mRNA

NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633

G

cysteinyl leukotriene receptor 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of CYSLTR2 mRNA

NCBI chr14:73,263,043...73,286,554
Ensembl chr14:73,263,043...73,286,554

G

diazepam binding inhibitor

increases expression

tributyltin results in increased expression of DBI mRNA

NCBI chr 1:120,041,010...120,048,826
Ensembl chr 1:120,041,010...120,048,808

G

D site albumin promoter binding protein

increases expression

tributyltin results in increased expression of DBP mRNA

NCBI chr 7:45,354,658...45,359,579
Ensembl chr 7:45,354,512...45,359,627

G

doublecortin-like kinase 1

increases expression

tributyltin results in increased expression of DCLK1 mRNA

NCBI chr 3:55,149,724...55,446,489
Ensembl chr 3:55,149,785...55,446,489

G

doublecortin-like kinase 3

increases expression

tributyltin results in increased expression of DCLK3 mRNA

NCBI chr 9:111,268,149...111,318,679
Ensembl chr 9:111,268,149...111,318,186

G

DNA-damage inducible transcript 3

increases expression

tributyltin results in increased expression of DDIT3 mRNA

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

DNA-damage-inducible transcript 4

increases expression

tributyltin results in increased expression of DDIT4 mRNA

NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656

G

delta 4-desaturase, sphingolipid 2

increases expression

tributyltin results in increased expression of DEGS2 mRNA

NCBI chr12:108,653,051...108,668,561
Ensembl chr12:108,644,970...108,668,570

G

DENN domain containing 10

increases expression

tributyltin results in increased expression of DENND10 mRNA

NCBI chr19:60,800,029...60,824,673
Ensembl chr19:60,800,023...60,824,665

G

DNA fragmentation factor, beta subunit

increases response to substance
multiple interactions

DFFB protein results in increased susceptibility to tributyltin
DFFB protein promotes the reaction [tributyltin results in decreased expression of CASP3 protein]; DFFB protein promotes the reaction [tributyltin results in decreased expression of CASP6 protein]; DFFB protein promotes the reaction [tributyltin results in increased cleavage of PARP1 protein]; DFFB protein promotes the reaction [tributyltin results in increased expression of H2AX protein modified form]

NCBI chr 4:154,048,904...154,059,578
Ensembl chr 4:154,048,906...154,059,583

G

diacylglycerol O-acyltransferase 1

increases expression
multiple interactions

tributyltin results in increased expression of DGAT1 mRNA
[tributyltin co-treated with LHB protein] results in increased expression of DGAT1 mRNA

PMID:23428407 PMID:38630605

NCBI chr15:76,386,215...76,396,167
Ensembl chr15:76,386,215...76,396,153

G

diacylglycerol O-acyltransferase 2

increases expression

tributyltin results in increased expression of DGAT2 mRNA

NCBI chr 7:98,802,870...98,831,920
Ensembl chr 7:98,802,865...98,831,926

G

dehydrogenase/reductase 9

decreases expression

tributyltin results in decreased expression of DHRS9 mRNA

NCBI chr 2:69,210,806...69,233,430
Ensembl chr 2:69,210,789...69,234,877

G

DEAH-box helicase 35

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of DHX35 mRNA

NCBI chr 2:158,636,674...158,700,141
Ensembl chr 2:158,636,727...158,700,134

G

DEAH-box helicase 40

increases expression
multiple interactions

tributyltin results in increased expression of DHX40 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of DHX40 mRNA

NCBI chr11:86,659,675...86,698,695
Ensembl chr11:86,659,672...86,698,572

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression

tributyltin results in decreased expression of DKK1 mRNA

NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065

G

dickkopf WNT signaling pathway inhibitor 3

increases expression

tributyltin results in increased expression of DKK3 mRNA

NCBI chr 7:111,715,226...111,758,689
Ensembl chr 7:111,715,224...111,758,264

G

delta like non-canonical Notch ligand 1

decreases expression

tributyltin results in decreased expression of DLK1 mRNA

PMID:23322813 PMID:24513447

NCBI chr12:109,418,411...109,429,262
Ensembl chr12:109,418,749...109,429,262

G

DNA methyltransferase 1-associated protein 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of DMAP1 mRNA

NCBI chr 4:117,531,878...117,539,450
Ensembl chr 4:117,531,878...117,539,470

G

deleted in malignant brain tumors 1

increases expression

tributyltin results in increased expression of DMBT1 mRNA

NCBI chr 7:130,633,787...130,723,357
Ensembl chr 7:130,633,776...130,723,357

G

dentin matrix protein 1

decreases expression
multiple interactions

tributyltin results in decreased expression of DMP1 mRNA
tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of DMP1 mRNA]

PMID:25777084 PMID:25932594

NCBI chr 5:104,345,441...104,361,968
Ensembl chr 5:104,350,479...104,361,968

G

dynein axonemal intermediate chain 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of DNAI4 mRNA

NCBI chr 4:102,891,954...102,971,524
Ensembl chr 4:102,895,262...102,971,752

G

DnaJ heat shock protein family (Hsp40) member C12

decreases expression

tributyltin results in decreased expression of DNAJC12 mRNA

NCBI chr10:63,218,222...63,244,619
Ensembl chr10:63,218,222...63,246,355

G

DNA methyltransferase 3B

decreases expression

tributyltin results in decreased expression of DNMT3B mRNA

NCBI chr 2:153,491,332...153,529,650
Ensembl chr 2:153,491,370...153,529,650

G

docking protein 4

increases expression

tributyltin results in increased expression of DOK4 mRNA

NCBI chr 8:95,590,456...95,602,940
Ensembl chr 8:95,590,456...95,602,958

G

dipeptidase 1

increases expression

tributyltin results in increased expression of DPEP1 mRNA

NCBI chr 8:123,913,069...123,928,551
Ensembl chr 8:123,912,981...123,928,551

G

dipeptidase 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of DPEP2 mRNA

NCBI chr 8:106,711,577...106,732,658
Ensembl chr 8:106,711,576...106,718,391
Ensembl chr 8:106,711,576...106,718,391

G

dermatopontin

increases expression

tributyltin results in increased expression of DPT mRNA

NCBI chr 1:164,624,232...164,651,843
Ensembl chr 1:164,624,213...164,651,835

G

desmoglein 1 gamma

increases expression

tributyltin results in increased expression of DSG1C mRNA

NCBI chr18:20,380,397...20,418,088
Ensembl chr18:20,380,397...20,418,088

G

dentin sialophosphoprotein

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of DSPP mRNA

NCBI chr 5:104,318,569...104,327,993
Ensembl chr 5:104,318,578...104,327,993

G

dual specificity phosphatase 10

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of DUSP10 mRNA

NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833

G

dual specificity phosphatase 13B

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of DUSP13B mRNA

NCBI chr14:21,783,463...21,792,947
Ensembl chr14:21,783,462...21,792,947

G

dual-specificity tyrosine phosphorylation regulated kinase 1b

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of DYRK1B mRNA

NCBI chr 7:27,878,880...27,896,896
Ensembl chr 7:27,878,894...27,886,719

G

dysferlin

decreases expression

tributyltin results in decreased expression of DYSF mRNA

NCBI chr 6:83,985,344...84,188,042
Ensembl chr 6:83,985,572...84,188,042

G

enoyl Coenzyme A hydratase domain containing 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ECHDC1 mRNA

NCBI chr10:29,174,140...29,222,657
Ensembl chr10:29,189,162...29,223,465

G

endothelin 1

increases expression

tributyltin results in increased expression of EDN1 mRNA

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

eukaryotic elongation factor-2 kinase

increases expression

tributyltin results in increased expression of EEF2K mRNA

NCBI chr 7:120,442,080...120,506,441
Ensembl chr 7:120,442,054...120,506,673

G

epidermal growth factor-containing fibulin-like extracellular matrix protein 1

increases expression

tributyltin results in increased expression of EFEMP1 mRNA

NCBI chr11:28,803,154...28,876,743
Ensembl chr11:28,803,204...28,876,743

G

early growth response 1

decreases expression

tributyltin results in decreased expression of EGR1 mRNA

NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037

G

early growth response 2

increases expression

tributyltin results in increased expression of EGR2 mRNA

NCBI chr10:67,370,334...67,383,354
Ensembl chr10:67,371,305...67,378,018

G

early growth response 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of EGR4 mRNA

NCBI chr 6:85,488,103...85,490,571
Ensembl chr 6:85,488,103...85,490,571

G

EH-domain containing 2

increases expression

tributyltin results in increased expression of EHD2 mRNA

NCBI chr 7:15,680,883...15,701,402
Ensembl chr 7:15,680,883...15,701,492

G

eukaryotic translation initiation factor 2, subunit 1 alpha

increases phosphorylation
multiple interactions

tributyltin results in increased phosphorylation of EIF2S1 protein
Dantrolene inhibits the reaction [tributyltin results in increased phosphorylation of EIF2S1 protein]

NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784

G

eukaryotic translation initiation factor 4B

multiple interactions

tributyltin affects the expression of and results in increased phosphorylation of EIF4B protein

NCBI chr15:101,982,208...102,005,608
Ensembl chr15:101,982,208...102,005,608

G

eukaryotic translation initiation factor 4E

multiple interactions

tributyltin affects the expression of and results in increased phosphorylation of EIF4E protein

NCBI chr 3:138,231,952...138,265,457
Ensembl chr 3:138,231,940...138,265,457

G

endosome-lysosome associated apoptosis and autophagy regulator 1

increases expression

tributyltin results in increased expression of ELAPOR1 mRNA

NCBI chr 3:108,362,995...108,444,064
Ensembl chr 3:108,363,010...108,443,852

G

E74-like factor 3

increases expression

tributyltin results in increased expression of ELF3 mRNA

NCBI chr 1:135,181,312...135,186,210
Ensembl chr 1:135,181,313...135,186,306

G

ELK4, member of ETS oncogene family

increases expression

tributyltin results in increased expression of ELK4 mRNA

NCBI chr 1:131,935,129...131,954,186
Ensembl chr 1:131,935,345...131,960,350

G

ELMO/CED-12 domain containing 3

increases expression

tributyltin results in increased expression of ELMOD3 mRNA

NCBI chr 6:72,542,905...72,575,396
Ensembl chr 6:72,542,905...72,575,396

G

ELOVL fatty acid elongase 3

decreases expression

tributyltin results in decreased expression of ELOVL3 mRNA

NCBI chr19:46,120,336...46,124,133
Ensembl chr19:46,120,336...46,124,133

G

ELOVL fatty acid elongase 7

increases expression

tributyltin results in increased expression of ELOVL7 mRNA

NCBI chr13:108,350,860...108,423,643
Ensembl chr13:108,350,938...108,422,217

G

enamelin

decreases expression
multiple interactions

tributyltin results in decreased expression of ENAM mRNA
Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of ENAM mRNA]

NCBI chr 5:88,635,834...88,653,908
Ensembl chr 5:88,635,834...88,653,908

G

endonuclease G

increases expression

tributyltin results in increased expression of ENDOG mRNA

NCBI chr 2:30,061,525...30,064,057
Ensembl chr 2:30,061,505...30,064,081

G

eomesodermin

decreases expression

tributyltin results in decreased expression of EOMES mRNA

NCBI chr 9:118,307,259...118,315,176
Ensembl chr 9:118,307,280...118,315,200

G

erythrocyte membrane protein band 4.1 like 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of EPB41L1 mRNA

NCBI chr 2:156,255,918...156,385,134
Ensembl chr 2:156,262,829...156,385,134

G

epithelial cell adhesion molecule

increases expression

tributyltin results in increased expression of EPCAM mRNA

NCBI chr17:87,943,407...87,958,555
Ensembl chr17:87,943,407...87,958,557

G

EPM2A interacting protein 1

increases expression
multiple interactions

tributyltin results in increased expression of EPM2AIP1 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of EPM2AIP1 mRNA

NCBI chr 9:111,100,913...111,108,161
Ensembl chr 9:111,100,997...111,108,161

G

erb-b2 receptor tyrosine kinase 2

increases expression

tributyltin results in increased expression of ERBB2 mRNA

NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542

G

ETS transcription factor

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ERG mRNA

NCBI chr16:95,160,028...95,387,452
Ensembl chr16:95,160,028...95,387,452

G

ER membrane associated RNA degradation

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ERMARD mRNA

NCBI chr17:15,261,825...15,310,307
Ensembl chr17:15,261,470...15,310,306

G

estrogen receptor 1 (alpha)

multiple interactions
increases expression
decreases expression
affects expression

tributyltin binds to and results in increased activity of ESR1 protein; tributyltin results in increased expression of and affects the localization of ESR1 protein
tributyltin results in increased expression of ESR1 mRNA
Estrogens inhibits the reaction [tributyltin results in decreased expression of ESR1 protein]; fulvestrant inhibits the reaction [tributyltin results in decreased expression of ESR1 protein]; tributyltin inhibits the reaction [Estrogens results in increased expression of ESR1 protein]
fulvestrant inhibits the reaction [tributyltin affects the expression of ESR1 protein]

PMID:23523586 PMID:25819109 PMID:27521499 PMID:28161095 PMID:29908848 More...

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

estrogen receptor 2 (beta)

affects expression

tributyltin affects the expression of ESR2 protein

NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033

G

electron transfer flavoprotein beta subunit lysine methyltransferase

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ETFBKMT mRNA

NCBI chr 6:149,042,980...149,052,669
Ensembl chr 6:149,041,347...149,052,669

G

electron transferring flavoprotein, dehydrogenase

increases expression
multiple interactions

tributyltin results in increased expression of ETFDH mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of ETFDH mRNA

PMID:24848799 PMID:31129395

NCBI chr 3:79,511,095...79,536,074
Ensembl chr 3:79,511,095...79,536,807

G

eva-1 homolog C

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of EVA1C mRNA

NCBI chr16:90,623,607...90,701,997
Ensembl chr16:90,623,607...90,701,997

G

exonuclease 3'-5' domain containing 2

increases expression
multiple interactions

tributyltin results in increased expression of EXD2 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of EXD2 mRNA

NCBI chr12:80,509,869...80,544,909
Ensembl chr12:80,509,869...80,547,001

G

exonuclease 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of EXO1 mRNA

NCBI chr 1:175,708,334...175,738,962
Ensembl chr 1:175,708,147...175,741,055

G

exocyst complex component 3-like 4

increases expression

tributyltin results in increased expression of EXOC3L4 mRNA

NCBI chr12:111,383,864...111,398,114
Ensembl chr12:111,383,451...111,398,112

G

exosome component 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of EXOSC3 mRNA

NCBI chr 4:45,316,613...45,320,616
Ensembl chr 4:45,316,613...45,342,732

G

ezrin

increases expression

tributyltin results in increased expression of EZR mRNA

NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183

G

F11 receptor

decreases expression

tributyltin results in decreased expression of F11R mRNA

NCBI chr 1:171,265,129...171,292,161
Ensembl chr 1:171,265,103...171,292,171

G

coagulation factor XIII, A1 subunit

increases expression

tributyltin results in increased expression of F13A1 mRNA

NCBI chr13:37,051,150...37,234,220
Ensembl chr13:37,051,152...37,234,220

G

F2R like trypsin receptor 1

increases expression

tributyltin results in increased expression of F2RL1 mRNA

NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735

G

fatty acid binding protein 3, muscle and heart

increases expression

tributyltin results in increased expression of FABP3 mRNA

NCBI chr 4:130,202,531...130,209,256
Ensembl chr 4:130,202,388...130,209,256

G

fatty acid binding protein 4, adipocyte

multiple interactions
increases expression

[triphenyltin chloride co-treated with tributyltin co-treated with dibutyldichlorotin] results in increased expression of FABP4 protein; diazepinylbenzoic acid inhibits the reaction [tributyltin results in increased expression of FABP4 mRNA]; dibutyldichlorotin inhibits the reaction [tributyltin results in increased expression of FABP4 protein]; T 0070907 inhibits the reaction [tributyltin results in increased expression of FABP4 mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; triphenyltin chloride affects the reaction [tributyltin results in increased expression of FABP4 protein]
tributyltin results in increased expression of FABP4 mRNA; tributyltin results in increased expression of FABP4 protein

PMID:15993011 PMID:21622945 PMID:22197818 PMID:23322813 PMID:23428407 More...

NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636

G

fatty acid binding protein 5, epidermal

increases expression

tributyltin results in increased expression of FABP5 mRNA

PMID:23428407 PMID:31939706

NCBI chr 3:10,077,645...10,081,670
Ensembl chr 3:10,077,608...10,081,667

G

family with sequence similarity 117, member A

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of FAM117A mRNA

NCBI chr11:95,227,844...95,272,698
Ensembl chr11:95,227,844...95,272,698

G

family with sequence similarity 131, member B

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of FAM131B mRNA

NCBI chr 6:42,292,239...42,301,574
Ensembl chr 6:42,292,246...42,301,577

G

family with sequence similarity 13, member A

increases expression

tributyltin results in increased expression of FAM13A mRNA

NCBI chr 6:58,910,521...59,001,487
Ensembl chr 6:58,909,075...59,001,534

G

family with sequence similarity 209

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of FAM209 mRNA

NCBI chr 2:172,314,474...172,316,236
Ensembl chr 2:172,314,440...172,316,251

G

family with sequence similarity 227, member A

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of FAM227A mRNA

NCBI chr15:79,493,777...79,543,157
Ensembl chr15:79,496,518...79,543,157

G

family with sequence similarity 76, member B

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of FAM76B mRNA

NCBI chr 9:13,738,490...13,766,033
Ensembl chr 9:13,739,012...13,766,283

G

family with sequence similarity 83, member B

increases expression

tributyltin results in increased expression of FAM83B mRNA

NCBI chr 9:76,394,742...76,474,397
Ensembl chr 9:76,397,336...76,474,398

G

family with sequence similarity 98, member A

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of FAM98A mRNA

NCBI chr17:75,844,080...75,858,941
Ensembl chr17:75,844,081...75,858,941

G

Fas cell surface death receptor

increases expression

tributyltin results in increased expression of FAS protein

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

fatty acid synthase

increases expression
multiple interactions

tributyltin results in increased expression of FASN mRNA
[tributyltin co-treated with LHB protein] results in increased expression of FASN mRNA

PMID:23322813 PMID:28011154 PMID:38630605

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

FAT atypical cadherin 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of FAT4 mRNA

NCBI chr 3:38,939,867...39,066,134
Ensembl chr 3:38,941,089...39,066,134

G

F-box and leucine-rich repeat protein 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of FBXL4 mRNA

NCBI chr 4:22,357,526...22,434,091
Ensembl chr 4:22,357,543...22,434,091

G

Fc fragment of IgG binding protein

increases expression

tributyltin results in increased expression of FCGBP mRNA

NCBI chr 7:27,770,661...27,820,289
Ensembl chr 7:27,770,661...27,820,287

G

ferrochelatase

decreases activity

tributyltin results in decreased activity of FECH protein

NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322

G

fermitin family member 1

increases expression

tributyltin results in increased expression of FERMT1 mRNA

NCBI chr 2:132,746,097...132,787,956
Ensembl chr 2:132,746,309...132,787,826

G

fibrinogen alpha chain

decreases expression

tributyltin results in decreased expression of FGA mRNA

NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934

G

fibrinogen beta chain

decreases expression

tributyltin results in decreased expression of FGB mRNA

NCBI chr 3:82,949,553...82,957,170
Ensembl chr 3:82,947,448...82,957,170

G

fibrinogen gamma chain

decreases expression

tributyltin results in decreased expression of FGG mRNA

NCBI chr 3:82,915,031...82,922,363
Ensembl chr 3:82,915,031...82,922,356

G

fibrinogen-like protein 2

increases expression

tributyltin results in increased expression of FGL2 mRNA

NCBI chr 5:21,577,671...21,583,384
Ensembl chr 5:21,577,640...21,583,372

G

FHF complex subunit HOOK interacting protein 1A

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of FHIP1A mRNA

NCBI chr 3:85,567,370...85,653,516
Ensembl chr 3:85,567,368...85,724,598

G

formin homology 2 domain containing 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of FHOD1 mRNA

NCBI chr 8:106,055,792...106,074,650
Ensembl chr 8:106,055,795...106,074,585

G

Friend leukemia integration 1

increases expression

tributyltin results in increased expression of FLI1 mRNA

NCBI chr 9:32,333,500...32,454,292
Ensembl chr 9:32,333,500...32,454,157

G

fibronectin 1

multiple interactions

tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of FN1 mRNA]

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

FBJ osteosarcoma oncogene

increases expression

tributyltin results in increased expression of FOS mRNA

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

fos-like antigen 1

decreases expression

tributyltin results in decreased expression of FOSL1 mRNA

NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974

G

forkhead box O1

decreases expression

tributyltin results in decreased expression of FOXO1 mRNA

NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642

G

follicle stimulating hormone beta

multiple interactions
decreases expression

Fatty Acids, Omega-3 inhibits the reaction [tributyltin results in decreased expression of FSHB protein]; tributyltin inhibits the reaction [Estrogens deficiency results in increased secretion of FSHB protein]
tributyltin results in decreased expression of FSHB mRNA; tributyltin results in decreased expression of FSHB protein

PMID:28161095 PMID:32783468 PMID:35430282

NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001

G

follicle stimulating hormone receptor

increases expression
multiple interactions

tributyltin results in increased expression of FSHR protein
[bisphenol A co-treated with tributyltin] results in increased expression of FSHR protein

NCBI chr17:89,292,380...89,508,103
Ensembl chr17:89,292,380...89,508,103

G

G0/G1 switch gene 2

increases expression

tributyltin results in increased expression of G0S2 mRNA

NCBI chr 1:192,954,468...192,955,496
Ensembl chr 1:192,954,469...192,955,525

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of G6PC1 mRNA
tributyltin results in increased expression of G6PC1 protein

PMID:31129395 PMID:31306684

NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729

G

glutamic acid decarboxylase 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GAD2 mRNA

NCBI chr 2:22,512,262...22,583,889
Ensembl chr 2:22,512,217...22,583,886

G

growth arrest and DNA-damage-inducible 45 beta

increases expression

tributyltin results in increased expression of GADD45B mRNA

NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038

G

growth arrest and DNA-damage-inducible 45 gamma

decreases expression

tributyltin results in decreased expression of GADD45G mRNA

NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504

G

galanin and GMAP prepropeptide

decreases expression
increases activity

tributyltin results in decreased expression of GAL protein
tributyltin results in increased activity of GAL protein

PMID:27310180 PMID:36319700

NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544

G

galactose-3-O-sulfotransferase 3

multiple interactions
decreases expression

[bisphenol A co-treated with tributyltin] results in decreased expression of GAL3ST3 mRNA
tributyltin results in decreased expression of GAL3ST3 mRNA

NCBI chr19:5,348,359...5,358,767
Ensembl chr19:5,348,359...5,358,766

G

galactokinase 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GALK2 mRNA

NCBI chr 2:125,701,029...125,826,218
Ensembl chr 2:125,701,029...125,826,219

G

polypeptide N-acetylgalactosaminyltransferase 12

increases expression

tributyltin results in increased expression of GALNT12 mRNA

NCBI chr 4:47,091,894...47,123,058
Ensembl chr 4:47,091,909...47,123,070

G

polypeptide N-acetylgalactosaminyltransferase 6

increases expression

tributyltin results in increased expression of GALNT6 mRNA

NCBI chr15:100,587,796...100,627,257
Ensembl chr15:100,589,694...100,627,257

G

galanin receptor 2

increases expression

tributyltin results in increased expression of GALR2 mRNA

NCBI chr11:116,170,520...116,174,776
Ensembl chr11:116,171,765...116,174,764

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression
multiple interactions

tributyltin results in decreased expression of GAPDH protein
tributyltin promotes the reaction [Tretinoin results in decreased expression of GAPDH protein]

NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430

G

GAR1 ribonucleoprotein

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GAR1 mRNA

NCBI chr 3:129,618,561...129,625,045
Ensembl chr 3:129,618,561...129,625,045

G

GATA binding protein 4

increases expression
multiple interactions

tributyltin results in increased expression of GATA4 protein
[bisphenol A co-treated with tributyltin] results in increased expression of GATA4 protein

PMID:31129395 PMID:36319700

NCBI chr14:63,436,363...63,509,161
Ensembl chr14:63,436,371...63,509,141

G

GATA binding protein 5

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of GATA5 mRNA

NCBI chr 2:179,966,881...179,977,296
Ensembl chr 2:179,966,926...179,976,492

G

glutamyl-tRNA amidotransferase subunit C

increases expression

tributyltin results in increased expression of GATC mRNA

NCBI chr 5:115,471,301...115,479,220
Ensembl chr 5:115,471,298...115,479,237

G

guanylate binding protein 2b

increases expression

tributyltin results in increased expression of GBP2B mRNA

NCBI chr 3:142,300,577...142,324,940
Ensembl chr 3:142,300,608...142,324,940

G

gastrulation brain homeobox 2

decreases expression

tributyltin results in decreased expression of GBX2 mRNA

NCBI chr 1:89,855,684...89,858,898
Ensembl chr 1:89,855,678...89,858,901

G

GRIP and coiled-coil domain containing 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GCC2 mRNA

NCBI chr10:58,091,240...58,141,421
Ensembl chr10:58,091,319...58,141,421

G

glucagon

decreases expression
decreases secretion

tributyltin results in decreased expression of GCG mRNA
tributyltin results in decreased secretion of GCG protein

NCBI chr 2:62,304,874...62,313,997
Ensembl chr 2:62,304,874...62,313,994

G

glucagon receptor

decreases expression

tributyltin results in decreased expression of GCGR protein

NCBI chr11:120,420,011...120,429,815
Ensembl chr11:120,421,525...120,429,812

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLC mRNA]

NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767

G

glutamate-cysteine ligase, modifier subunit

multiple interactions

PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLM mRNA]

NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381

G

guanine deaminase

increases expression

tributyltin results in increased expression of GDA mRNA

PMID:21683754 PMID:31939706

NCBI chr19:21,368,671...21,450,025
Ensembl chr19:21,368,671...21,450,809

G

glycerophosphodiester phosphodiesterase domain containing 1

increases expression

tributyltin results in increased expression of GDPD1 mRNA

NCBI chr11:86,924,620...86,964,963
Ensembl chr11:86,924,693...86,964,888

G

GTP binding protein overexpressed in skeletal muscle

increases expression

tributyltin results in increased expression of GEM mRNA

NCBI chr 4:11,702,379...11,714,993
Ensembl chr 4:11,704,457...11,714,752

G

guided entry of tail-anchored proteins factor 3, ATPase

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GET3 mRNA

NCBI chr 8:85,744,558...85,751,916
Ensembl chr 8:85,744,560...85,751,910

G

glial fibrillary acidic protein

decreases expression
multiple interactions
increases expression

tributyltin results in decreased expression of GFAP protein
Phycocyanin inhibits the reaction [tributyltin results in increased expression of GFAP protein]

PMID:23743147 PMID:26079211

NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738

G

gamma-glutamylamine cyclotransferase

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of GGACT mRNA

NCBI chr14:123,128,272...123,151,173
Ensembl chr14:123,053,635...123,151,169

G

gypsy retrotransposon integrase 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GIN1 mRNA

NCBI chr 1:97,697,894...97,721,435
Ensembl chr 1:97,697,897...97,721,434

G

GIPC PDZ domain containing family, member 2

increases expression

tributyltin results in increased expression of GIPC2 mRNA

NCBI chr 3:151,799,476...151,871,537
Ensembl chr 3:151,799,170...151,871,867

G

gap junction protein, alpha 1

decreases expression

tributyltin results in decreased expression of GJA1 protein

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

glycerol kinase

increases expression

tributyltin results in increased expression of GK mRNA

NCBI chr X:84,745,543...84,820,425
Ensembl chr X:84,745,543...84,820,425

G

glycine receptor, alpha 3 subunit

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of GLRA3 mRNA

NCBI chr 8:56,393,454...56,583,111
Ensembl chr 8:56,393,495...56,583,105

G

predicted gene 7030

increases expression

tributyltin results in increased expression of RT1-CE5 mRNA

NCBI chr17:36,438,501...36,440,317
Ensembl chr17:36,420,611...36,440,317

G

guanine nucleotide binding protein (G protein), gamma 11

increases expression

tributyltin results in increased expression of GNG11 mRNA

NCBI chr 6:4,003,987...4,008,445
Ensembl chr 6:4,003,904...4,008,445

G

gonadotropin releasing hormone 1

multiple interactions
decreases expression

tributyltin inhibits the reaction [Estrogens deficiency results in increased expression of GNRH1 mRNA]; tributyltin inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]
tributyltin results in decreased expression of GNRH1 mRNA

NCBI chr14:67,982,717...67,986,889
Ensembl chr14:67,982,630...67,986,888

G

GON7 subunit of KEOPS complex

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GON7 mRNA

NCBI chr12:102,719,534...102,724,069
Ensembl chr12:102,719,534...102,724,062

G

glycerol-3-phosphate acyltransferase 3

increases expression

tributyltin results in increased expression of GPAT3 mRNA

NCBI chr 5:100,994,095...101,046,968
Ensembl chr 5:100,993,579...101,046,968

G

glypican 6

increases expression

tributyltin results in increased expression of GPC6 mRNA

NCBI chr14:117,162,332...118,216,941
Ensembl chr14:117,162,727...118,213,956

G

glycoprotein (transmembrane) nmb

decreases expression

tributyltin results in decreased expression of GPNMB mRNA

NCBI chr 6:49,013,449...49,044,413
Ensembl chr 6:49,013,480...49,047,863

G

G protein-coupled receptor 155

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GPR155 mRNA

NCBI chr 2:73,171,850...73,216,842
Ensembl chr 2:73,171,850...73,216,916

G

G protein-coupled receptor 158

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GPR158 mRNA

NCBI chr 2:21,372,378...21,835,355
Ensembl chr 2:21,372,353...21,835,358

G

G protein-coupled receptor 45

decreases expression

tributyltin results in decreased expression of GPR45 mRNA

NCBI chr 1:42,992,032...43,074,611
Ensembl chr 1:42,992,032...43,074,616

G

glutamic pyruvate transaminase (alanine aminotransferase) 2

decreases expression

tributyltin results in decreased expression of GPT2 mRNA

NCBI chr 8:86,219,090...86,255,531
Ensembl chr 8:86,219,205...86,254,189

G

glutathione peroxidase 6

increases expression

tributyltin results in increased expression of GPX6 mRNA

NCBI chr13:21,479,635...21,503,795
Ensembl chr13:21,496,295...21,503,794

G

growth factor receptor bound protein 14

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GRB14 mRNA

NCBI chr 2:64,742,820...64,853,143
Ensembl chr 2:64,742,820...64,855,331

G

gremlin 2, DAN family BMP antagonist

increases expression

tributyltin results in increased expression of GREM2 mRNA

NCBI chr 1:174,661,352...174,749,386
Ensembl chr 1:174,661,351...174,749,385

G

glutamate receptor, ionotropic, AMPA1 (alpha 1)

decreases expression

tributyltin results in decreased expression of GRIA1 mRNA

NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070

G

glutamate receptor, ionotropic, AMPA2 (alpha 2)

decreases expression

tributyltin results in decreased expression of GRIA2 mRNA; tributyltin results in decreased expression of GRIA2 protein

NCBI chr 3:80,588,757...80,711,534
Ensembl chr 3:80,588,757...80,710,142

G

glutamate receptor, ionotropic, AMPA3 (alpha 3)

increases expression

tributyltin results in increased expression of GRIA3 mRNA

NCBI chr X:40,489,351...40,767,478
Ensembl chr X:40,489,731...40,767,478

G

glutamate receptor, ionotropic, AMPA4 (alpha 4)

increases expression

tributyltin results in increased expression of GRIA4 mRNA

NCBI chr 9:4,417,893...4,796,250
Ensembl chr 9:4,417,896...4,796,234

G

glutamate receptor, ionotropic, NMDA1 (zeta 1)

decreases expression

tributyltin results in decreased expression of GRIN1 mRNA

NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199

G

glutamate receptor, ionotropic, NMDA2A (epsilon 1)

decreases expression

tributyltin results in decreased expression of GRIN2A mRNA

NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424

G

glutamate receptor, ionotropic, NMDA2B (epsilon 2)

increases expression

tributyltin results in increased expression of GRIN2B mRNA

NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509

G

G protein-coupled receptor kinase 5

decreases expression

tributyltin results in decreased expression of GRK5 mRNA

NCBI chr19:60,877,995...61,084,406
Ensembl chr19:60,878,187...61,084,406

G

glutaredoxin, cysteine rich 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of GRXCR2 mRNA

NCBI chr18:42,118,388...42,132,114
Ensembl chr18:42,118,388...42,132,114

G

gasdermin E

increases expression

tributyltin results in increased expression of GSDME mRNA

NCBI chr 6:50,167,013...50,240,837
Ensembl chr 6:50,165,868...50,240,842

G

glutathione reductase

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [tributyltin results in increased expression of GSR protein]; Phycocyanin inhibits the reaction [tributyltin results in increased expression of GSR protein]

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase, alpha 1 (Ya)

increases expression

tributyltin results in increased expression of GSTA1 mRNA

NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966

G

glutathione S-transferase omega 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of GSTO1 mRNA

NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229

G

GTP binding protein 6 (putative)

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of GTPBP6 mRNA

NCBI chr 5:110,251,842...110,256,063
Ensembl chr 5:110,251,841...110,256,063

G

guanylate cyclase 2c

increases expression

tributyltin results in increased expression of GUCY2C mRNA

NCBI chr 6:136,674,282...136,758,740
Ensembl chr 6:136,674,282...136,758,763

G

guanylate cyclase 2e

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of GUCY2D mRNA

NCBI chr11:69,108,943...69,128,083
Ensembl chr11:69,108,943...69,127,862

G

granzyme A

increases expression

tributyltin results in increased expression of GZMA mRNA

NCBI chr13:113,230,358...113,237,515
Ensembl chr13:113,230,359...113,237,515

G

histocompatibility 2, Q region locus 2

increases expression

tributyltin results in increased expression of H2-Q2 mRNA

NCBI chr17:35,561,283...35,565,740
Ensembl chr17:35,561,218...35,565,738

G

H2A clustered histone 4

increases expression

tributyltin results in increased expression of H2AC4 mRNA

NCBI chr13:23,935,061...23,935,577
Ensembl chr13:23,935,109...23,935,581

G

H2A.X variant histone

increases expression
multiple interactions
increases phosphorylation

tributyltin results in increased expression of H2AX protein modified form
Acetylcysteine inhibits the reaction [tributyltin results in increased expression of H2AX protein modified form]; Phycocyanin inhibits the reaction [tributyltin results in increased expression of H2AX protein modified form]
2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased phosphorylation of H2AX protein]; DFFB protein promotes the reaction [tributyltin results in increased expression of H2AX protein modified form]

PMID:26079211 PMID:31401084 PMID:36319700

NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374

G

H3 clustered histone 1

increases expression

tributyltin results in increased expression of H3C1 mRNA

NCBI chr13:23,945,868...23,946,369
Ensembl chr13:23,945,836...23,946,369

G

H3 clustered histone 14

increases expression

tributyltin results in increased expression of H3C3 mRNA

NCBI chr 3:96,154,001...96,154,664
Ensembl chr 3:96,154,001...96,155,825

G

hydroxyacyl-Coenzyme A dehydrogenase

increases expression

tributyltin results in increased expression of HADH mRNA

NCBI chr 3:131,027,068...131,065,750
Ensembl chr 3:131,027,068...131,065,750

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

increases expression

tributyltin results in increased expression of HADHA mRNA

NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

tributyltin results in increased expression of HADHB mRNA

PMID:23428407 PMID:24848799

NCBI chr 5:30,360,251...30,389,591
Ensembl chr 5:30,360,246...30,389,591

G

hepcidin antimicrobial peptide

decreases expression

tributyltin results in decreased expression of HAMP mRNA

NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457

G

heart and neural crest derivatives expressed 1

decreases expression

tributyltin results in decreased expression of HAND1 mRNA

NCBI chr11:57,719,539...57,722,973
Ensembl chr11:57,719,531...57,723,644

G

hydroxyacid oxidase 2

increases expression

tributyltin results in increased expression of HAO2 mRNA

NCBI chr 3:98,781,835...98,802,692
Ensembl chr 3:98,781,837...98,800,555

G

histone aminotransferase 1

increases activity

tributyltin results in increased activity of HAT1 protein

NCBI chr 2:71,219,604...71,271,966
Ensembl chr 2:71,219,302...71,271,966

G

hemoglobin, beta adult s chain

increases expression

tributyltin results in increased expression of HBB-BS mRNA

NCBI chr 7:103,475,730...103,477,135
Ensembl chr 7:103,475,741...103,477,303

G

hemoglobin, beta adult t chain

increases expression

tributyltin results in increased expression of HBB-BT mRNA

NCBI chr 7:103,461,731...103,463,130
Ensembl chr 7:103,461,731...103,463,203

G

hemolytic complement

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of C5 mRNA

NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450

G

haloacid dehalogenase like hydrolase domain containing 5

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of HDHD5 mRNA

NCBI chr 6:120,486,453...120,508,319
Ensembl chr 6:120,486,455...120,508,280

G

HECT domain E3 ubiquitin protein ligase 2

increases expression

tributyltin results in increased expression of HECTD2 mRNA

NCBI chr19:36,531,420...36,598,535
Ensembl chr19:36,532,039...36,598,535

G

hephaestin

increases expression

tributyltin results in increased expression of HEPH mRNA

NCBI chr X:95,499,042...95,618,091
Ensembl chr X:95,498,965...95,618,091

G

Holliday junction recognition protein

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of HJURP mRNA

NCBI chr 1:88,186,578...88,205,366
Ensembl chr 1:88,190,193...88,205,355

G

hexokinase domain containing 1

increases expression

tributyltin results in increased expression of HKDC1 mRNA

NCBI chr10:62,218,916...62,259,490
Ensembl chr10:62,218,916...62,258,270

G

5-hydroxymethylcytosine (hmC) binding, ES cell specific

increases expression

tributyltin results in increased expression of HMCES mRNA

NCBI chr 6:87,890,889...87,913,603
Ensembl chr 6:87,890,917...87,913,611

G

high mobility group AT-hook 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of HMGA1 mRNA

NCBI chr17:27,774,798...27,782,649
Ensembl chr17:27,775,471...27,782,648

G

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of HMGCS2 mRNA
tributyltin results in increased expression of HMGCS2 mRNA

NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054

G

hyaluronan mediated motility receptor (RHAMM)

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of HMMR mRNA

NCBI chr11:40,592,215...40,624,290
Ensembl chr11:40,592,222...40,624,249

G

heme oxygenase 1

increases expression

tributyltin results in increased expression of HMOX1 protein

PMID:28707438 PMID:36858641

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

heterogeneous nuclear ribonucleoprotein F

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of HNRNPF mRNA

NCBI chr 6:117,877,301...117,902,583
Ensembl chr 6:117,877,285...117,902,583

G

homeobox A2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of HOXA2 mRNA

NCBI chr 6:52,139,389...52,141,808
Ensembl chr 6:52,139,397...52,141,811

G

hydroxyprostaglandin dehydrogenase 15 (NAD)

increases expression

tributyltin results in increased expression of HPGD mRNA

NCBI chr 8:56,747,587...56,774,081
Ensembl chr 8:56,747,620...56,774,078

G

histamine receptor H1

decreases expression

tributyltin results in decreased expression of HRH1 mRNA

NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257

G

histamine receptor H3

decreases expression

tributyltin results in decreased expression of HRH3 mRNA

NCBI chr 2:179,741,258...179,746,264
Ensembl chr 2:179,741,258...179,746,281

G

homologous recombination factor with OB-fold

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of HROB mRNA

NCBI chr11:102,139,677...102,156,009
Ensembl chr11:102,139,708...102,156,013

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity
increases expression
multiple interactions

tributyltin results in decreased activity of HSD11B2 protein
tributyltin results in increased expression of HSD11B2 mRNA
Cycloheximide promotes the reaction [tributyltin results in increased expression of HSD11B2 mRNA]; Dactinomycin inhibits the reaction [tributyltin results in increased expression of HSD11B2 mRNA]; Glycyrrhetinic Acid inhibits the reaction [tributyltin results in increased activity of HSD11B2 protein]; LG 100754 inhibits the reaction [tributyltin results in increased activity of HSD11B2 protein]; RXRA protein affects the reaction [tributyltin results in increased expression of and results in increased activity of HSD11B2 protein]; RXRA protein affects the reaction [tributyltin results in increased expression of HSD11B2 mRNA]; RXRA protein affects the reaction [tributyltin results in increased expression of HSD11B2 protein]; tributyltin results in increased expression of and results in increased activity of HSD11B2 protein

PMID:16184081 PMID:22796344 PMID:31927052

NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620

G

hydroxysteroid (17-beta) dehydrogenase 1

increases activity
increases expression

tributyltin results in increased activity of HSD17B1 protein
tributyltin results in increased expression of HSD17B1 mRNA

NCBI chr11:100,968,792...100,972,014
Ensembl chr11:100,969,237...100,971,353

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions
decreases expression

[bisphenol A co-treated with tributyltin] results in decreased expression of HSD17B3 mRNA
tributyltin results in decreased expression of HSD17B3 mRNA; tributyltin results in decreased expression of HSD17B3 protein

PMID:31129395 PMID:35430282

NCBI chr13:64,206,088...64,237,076
Ensembl chr13:64,206,080...64,237,044

G

hydroxysteroid (17-beta) dehydrogenase 6

increases expression

tributyltin results in increased expression of HSD17B6 mRNA

NCBI chr10:127,826,800...127,843,517
Ensembl chr10:127,826,805...127,843,480

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression

tributyltin results in decreased expression of HSD3B1 mRNA; tributyltin results in decreased expression of HSD3B1 protein

NCBI chr 3:98,749,672...98,767,110
Ensembl chr 3:98,759,510...98,767,110

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

increases expression

tributyltin results in increased expression of HSD3B2 mRNA

NCBI chr 3:98,618,423...98,631,859
Ensembl chr 3:98,616,571...98,631,859

G

heat shock protein 1A

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of HSPA1A mRNA

NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132

G

heat shock protein 1B

decreases expression

tributyltin results in decreased expression of HSPA1B mRNA

NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214

G

heat shock protein 5

multiple interactions
increases expression
decreases expression

4-phenylbutyric acid inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]; Dantrolene inhibits the reaction [tributyltin results in increased expression of HSPA5 protein]
tributyltin results in decreased expression of HSPA5 mRNA

PMID:23743301 PMID:27678064

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

heat shock protein 8

decreases expression

tributyltin results in decreased expression of HSPA8 mRNA

NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383

G

heat shock protein 8

increases expression

tributyltin results in increased expression of HSPB8 mRNA

NCBI chr 5:116,546,550...116,560,923
Ensembl chr 5:116,546,550...116,560,923

G

5-hydroxytryptamine (serotonin) receptor 2A

decreases expression

tributyltin results in decreased expression of HTR2A mRNA

NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934

G

intercellular adhesion molecule 1

increases expression

tributyltin results in increased expression of ICAM1 mRNA

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

inhibitor of DNA binding 3

decreases expression

tributyltin results in decreased expression of ID3 mRNA

NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066

G

isocitrate dehydrogenase 3 (NAD+) alpha

increases expression
multiple interactions

tributyltin results in increased expression of IDH3A mRNA
IDH3A protein affects the reaction [tributyltin results in decreased expression of CCNB1 protein]; IDH3A protein affects the reaction [tributyltin results in decreased expression of CDC25C protein]

PMID:23428407 PMID:26961604

NCBI chr 9:54,493,795...54,511,946
Ensembl chr 9:54,493,618...54,511,945

G

immediate early response 3

increases expression

tributyltin results in increased expression of IER3 mRNA

NCBI chr17:36,132,605...36,133,803
Ensembl chr17:36,132,576...36,133,815

G

interferon, alpha-inducible protein 27 like 2A

increases expression

tributyltin results in increased expression of IFI27L2A mRNA

NCBI chr12:103,400,132...103,409,939
Ensembl chr12:103,408,426...103,409,939

G

interferon induced transmembrane protein 3

increases expression

tributyltin results in increased expression of IFITM3 mRNA

NCBI chr 7:140,589,503...140,590,657
Ensembl chr 7:140,589,499...140,590,683

G

interferon (alpha and beta) receptor 2

increases expression

tributyltin results in increased expression of IFNAR2 mRNA

NCBI chr16:91,166,517...91,202,477
Ensembl chr16:91,169,671...91,202,477

G

interferon gamma

multiple interactions
affects expression

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [tributyltin results in increased expression of and results in increased secretion of IFNG protein]; tributyltin results in increased expression of and results in increased secretion of IFNG protein
tributyltin affects the expression of IFNG mRNA

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

immunoglobulin superfamily, DCC subclass, member 4

increases expression

tributyltin results in increased expression of IGDCC4 mRNA

NCBI chr 9:65,008,246...65,045,225
Ensembl chr 9:65,008,768...65,045,222

G

insulin-like growth factor binding protein 1

decreases expression

tributyltin results in decreased expression of IGFBP1 mRNA

NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546

G

immunoglobulin superfamily, member 11

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of IGSF11 mRNA

NCBI chr16:38,712,840...38,847,521
Ensembl chr16:38,713,033...38,847,521

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immunoglobulin superfamily, member 23

increases expression

tributyltin results in increased expression of IGSF23 mRNA

NCBI chr 7:19,671,230...19,687,579
Ensembl chr 7:19,671,230...19,684,681

G

immunoglobulin superfamily, member 9

increases expression

tributyltin results in increased expression of IGSF9 mRNA

NCBI chr 1:172,307,616...172,326,444
Ensembl chr 1:172,309,355...172,326,445

G

Indian hedgehog

increases expression

tributyltin results in increased expression of IHH mRNA

NCBI chr 1:74,984,474...74,990,831
Ensembl chr 1:74,984,474...74,990,831

G

interleukin 10

increases expression

tributyltin results in increased expression of IL10 mRNA

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 13

decreases expression

tributyltin results in decreased expression of IL13 protein

NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529

G

interleukin 15

multiple interactions

[tributyltin co-treated with LHB protein] results in decreased secretion of IL15 protein

NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851

G

interleukin 16

multiple interactions

[tributyltin co-treated with LHB protein] results in decreased secretion of IL16 protein

NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934

G

interleukin 18

multiple interactions

[tributyltin co-treated with LHB protein] results in increased secretion of IL18 protein

NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140

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interleukin 1 alpha

multiple interactions
increases expression

1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [tributyltin results in increased expression of IL1A protein]; Ethidium inhibits the reaction [tributyltin results in increased expression of IL1A protein]; Rotenone inhibits the reaction [tributyltin results in increased expression of IL1A protein]

PMID:8875956 PMID:9221826

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

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interleukin 1 beta

multiple interactions
affects secretion
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased expression of and results in increased secretion of IL1B protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole affects the reaction [tributyltin affects the secretion of IL1B protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [tributyltin results in increased expression of and results in increased secretion of IL1B protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [tributyltin results in increased expression of IL1B mRNA]; CU-CPT22 inhibits the reaction [tributyltin results in increased expression of IL1B protein]; tributyltin results in increased expression of and results in increased secretion of IL1B protein; U 0126 affects the reaction [tributyltin affects the secretion of IL1B protein]
tributyltin results in increased expression of IL1B mRNA; tributyltin results in increased expression of IL1B protein

PMID:25382723 PMID:29951691 PMID:35405286 PMID:36319700

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

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interleukin 1 receptor, type I

decreases expression

tributyltin results in decreased expression of IL1R1 mRNA

NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417

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interleukin 3 receptor, alpha chain

increases expression

tributyltin results in increased expression of IL3RA mRNA

NCBI chr14:8,114,270...8,123,851
Ensembl chr14:8,113,752...8,123,488

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interleukin 4

decreases expression

tributyltin results in decreased expression of IL4 protein

NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496

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interleukin 5 receptor, alpha

decreases expression

tributyltin results in decreased expression of IL5RA mRNA

NCBI chr 6:106,687,336...106,725,998
Ensembl chr 6:106,687,318...106,725,998

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interleukin 6

increases expression
multiple interactions

tributyltin results in increased expression of IL6 protein
tributyltin results in increased expression of IL6 mRNA; tributyltin results in increased expression of IL6 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased expression of IL6 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased expression of IL6 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [tributyltin results in increased expression of IL6 protein]; CU-CPT22 inhibits the reaction [tributyltin results in increased expression of IL6 protein]; tributyltin results in increased expression of and results in increased secretion of IL6 protein

PMID:23743147 PMID:29951691 PMID:30172001 PMID:35405286

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

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interleukin 9

multiple interactions

[tributyltin co-treated with LHB protein] results in increased secretion of IL9 protein

NCBI chr13:56,627,090...56,630,070
Ensembl chr13:56,627,090...56,630,059

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interphotoreceptor matrix proteoglycan 2

decreases expression

tributyltin results in decreased expression of IMPG2 mRNA

NCBI chr16:56,019,447...56,094,119
Ensembl chr16:56,024,676...56,094,119

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inhibin beta-B

increases expression

tributyltin results in increased expression of INHBB mRNA

NCBI chr 1:119,343,193...119,349,978
Ensembl chr 1:119,343,195...119,349,978

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insulin I

increases expression
increases secretion
multiple interactions

tributyltin results in increased expression of INS1 mRNA; tributyltin results in increased expression of INS1 protein
tributyltin results in increased secretion of INS1 protein
Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Acetylcysteine inhibits the reaction [tributyltin results in increased secretion of INS1 protein]; fulvestrant inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Ro 32-0432 inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Fulvestrant inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Ro 32-0432 inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]
tributyltin promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]

PMID:27384973 PMID:28161095 PMID:28180948 PMID:28397090 PMID:30172001 More...

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

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insulin II

multiple interactions
increases expression

tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA alternative form]
[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA; [tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 protein; Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]; diazepinylbenzoic acid inhibits the reaction [[tributyltin co-treated with [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein]] results in increased expression of ABCA1 mRNA]; Fulvestrant inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]; Ro 32-0432 inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]; tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]; tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of DMP1 mRNA]; tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SP7 mRNA]; tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]; tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]; tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased secretion of TNFRSF11B protein]; tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased secretion of ADIPOQ protein]; tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]
tributyltin results in increased expression of INS2 mRNA

PMID:22197818 PMID:25932594 PMID:28180948 PMID:31016361 PMID:31306684 More...

NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118

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insulin induced gene 2

decreases expression

tributyltin results in decreased expression of INSIG2 mRNA

NCBI chr 1:121,232,082...121,260,391
Ensembl chr 1:121,232,082...121,260,318

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insulin receptor

affects methylation
multiple interactions

tributyltin affects the methylation of INSR gene
tributyltin results in decreased expression of and results in decreased phosphorylation of INSR protein

PMID:28011154 PMID:28397090

NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617

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interferon regulatory factor 5

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of IRF5 mRNA

NCBI chr 6:29,526,129...29,541,874
Ensembl chr 6:29,526,624...29,541,870

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insulin receptor substrate 1

multiple interactions
increases expression

tributyltin results in decreased expression of and results in decreased phosphorylation of IRS1 protein
tributyltin results in increased expression of IRS1 mRNA

PMID:28397090 PMID:30027469

NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137

G

isochorismatase domain containing 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ISOC1 mRNA

NCBI chr18:58,792,554...58,812,642
Ensembl chr18:58,792,538...58,813,440

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integrin alpha 4

increases expression

tributyltin results in increased expression of ITGA4 mRNA

NCBI chr 2:79,084,767...79,163,458
Ensembl chr 2:79,085,770...79,163,467

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integrin alpha 6

increases expression

tributyltin results in increased expression of ITGA6 mRNA

NCBI chr 2:71,617,236...71,688,761
Ensembl chr 2:71,575,960...71,688,760

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integrin alpha L

increases expression

tributyltin results in increased expression of ITGAL mRNA

NCBI chr 7:126,895,404...126,934,309
Ensembl chr 7:126,895,432...126,934,310

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integrin alpha M

increases expression
multiple interactions

tributyltin results in increased expression of ITGAM mRNA
Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in increased expression of ITGAM mRNA]
[Phycocyanin co-treated with tributyltin] results in increased expression of ITGAM protein

PMID:22749964 PMID:26079211

NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663

G

integrin beta 2

increases expression
multiple interactions
affects localization

tributyltin results in increased expression of ITGB2 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin affects the localization of ITGB2 protein]

PMID:20883105 PMID:26314263

NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542

G

integrin beta 2-like

increases expression

tributyltin results in increased expression of ITGB2L mRNA

NCBI chr16:96,223,488...96,244,861
Ensembl chr16:96,223,488...96,244,819

G

integrin beta 4

increases expression

tributyltin results in increased expression of ITGB4 mRNA

NCBI chr11:115,865,556...115,899,238
Ensembl chr11:115,865,535...115,899,238

G

intelectin 1 (galactofuranose binding)

increases expression

tributyltin results in increased expression of ITLN1 mRNA

NCBI chr 1:171,345,691...171,362,893
Ensembl chr 1:171,345,690...171,362,862

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inositol 1,4,5-triphosphate receptor 3

increases expression

tributyltin results in increased expression of ITPR3 mRNA

NCBI chr17:27,275,976...27,341,197
Ensembl chr17:27,276,278...27,341,197

G

intersectin 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ITSN2 mRNA

NCBI chr12:4,642,792...4,763,952
Ensembl chr12:4,642,638...4,763,962

G

junction adhesion molecule 2

increases expression

tributyltin results in increased expression of JAM2 mRNA

NCBI chr16:84,571,011...84,623,268
Ensembl chr16:84,571,011...84,622,816

G

junction adhesion molecule 3

increases expression

tributyltin results in increased expression of JAM3 mRNA

NCBI chr 9:27,008,680...27,066,739
Ensembl chr 9:27,008,680...27,066,717

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immunoglobulin joining chain

increases expression

tributyltin results in increased expression of JCHAIN mRNA

NCBI chr 5:88,667,663...88,675,667
Ensembl chr 5:88,667,668...88,675,750

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junctional cadherin complex regulator

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of JHY mRNA

NCBI chr 9:40,806,147...40,877,560
Ensembl chr 9:40,806,145...40,875,414

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jun proto-oncogene

increases phosphorylation

tributyltin results in increased phosphorylation of JUN protein

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

jun B proto-oncogene

increases expression

tributyltin results in increased expression of JUNB mRNA

NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347

G

KN motif and ankyrin repeat domains 2

increases expression

tributyltin results in increased expression of KANK2 mRNA

NCBI chr 9:21,678,069...21,709,842
Ensembl chr 9:21,678,080...21,710,040

G

kelch repeat and BTB (POZ) domain containing 11

increases expression

tributyltin results in increased expression of KBTBD11 mRNA

NCBI chr 8:15,059,408...15,083,333
Ensembl chr 8:15,061,025...15,083,333

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potassium channel, subfamily K, member 3

increases expression

tributyltin results in increased expression of KCNK3 mRNA

NCBI chr 5:30,745,514...30,782,614
Ensembl chr 5:30,745,514...30,782,615

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potassium voltage-gated channel, subfamily Q, member 1

increases expression

tributyltin results in increased expression of KCNQ1 mRNA

NCBI chr 7:142,660,614...142,980,787
Ensembl chr 7:142,660,099...142,980,779

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potassium channel tetramerisation domain containing 8

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of KCTD8 mRNA

NCBI chr 5:69,266,628...69,499,052
Ensembl chr 5:69,266,628...69,499,022

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kelch-like ECH-associated protein 1

decreases expression

tributyltin results in decreased expression of KEAP1 protein

NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657

G

kinesin family member 2A

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of KIF2A mRNA

NCBI chr13:107,095,504...107,158,931
Ensembl chr13:107,095,504...107,158,634

G

kinesin family member 3B

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of KIF3B mRNA

NCBI chr 2:153,132,028...153,175,310
Ensembl chr 2:153,133,333...153,175,310

G

KiSS-1 metastasis-suppressor

multiple interactions

tributyltin inhibits the reaction [KISS1 protein results in increased secretion of LHB protein]

NCBI chr 1:133,249,625...133,257,460
Ensembl chr 1:133,237,565...133,257,460
Ensembl chr 1:133,237,565...133,257,460

G

Kruppel-like transcription factor 15

decreases expression

tributyltin results in decreased expression of KLF15 mRNA

NCBI chr 6:90,437,785...90,468,785
Ensembl chr 6:90,439,558...90,452,220

G

Kruppel-like transcription factor 2 (lung)

increases expression

tributyltin results in increased expression of KLF2 mRNA

NCBI chr 8:73,072,906...73,075,498
Ensembl chr 8:73,072,877...73,075,500

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Kruppel-like transcription factor 4 (gut)

increases expression

tributyltin results in increased expression of KLF4 mRNA

NCBI chr 4:55,527,137...55,536,984
Ensembl chr 4:55,527,143...55,532,466

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kelch-like 9

increases expression

tributyltin results in increased expression of KLHL9 mRNA

NCBI chr 4:88,636,529...88,640,745
Ensembl chr 4:88,636,529...88,640,702

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kininogen 1

increases expression

tributyltin results in increased expression of KNG1 mRNA

NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828

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kinetochore-localized astrin/SPAG5 binding

decreases expression

tributyltin results in decreased expression of KNSTRN mRNA

NCBI chr 2:118,644,470...118,667,691
Ensembl chr 2:118,644,484...118,684,438

G

keratin 19

increases expression

tributyltin results in increased expression of KRT19 mRNA

NCBI chr11:100,031,636...100,036,752
Ensembl chr11:100,031,636...100,039,491

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keratin 79

increases expression

tributyltin results in increased expression of KRT79 mRNA

NCBI chr15:101,837,767...101,848,759
Ensembl chr15:101,837,767...101,848,759

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kinase suppressor of ras 1

increases expression

tributyltin results in increased expression of KSR1 mRNA

NCBI chr11:78,904,266...79,037,357
Ensembl chr11:78,904,266...79,037,233

G

lysosomal-associated membrane protein 3

decreases expression

tributyltin results in decreased expression of LAMP3 mRNA

NCBI chr16:19,472,131...19,525,115
Ensembl chr16:19,472,128...19,525,125

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leucyl-tRNA synthetase, mitochondrial

affects expression

tributyltin affects the expression of LARS2 mRNA

NCBI chr 9:123,196,001...123,291,731
Ensembl chr 9:123,195,992...123,291,731

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leptin

increases expression
increases secretion
decreases expression
multiple interactions

tributyltin results in increased expression of LEP mRNA
tributyltin results in increased secretion of LEP protein
tributyltin results in decreased expression of LEP protein
[Dietary Fats co-treated with tributyltin] results in increased expression of LEP protein
tributyltin results in increased expression of LEP protein

PMID:27310180 PMID:28011154 PMID:28161095 PMID:29787037 PMID:30172001

NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876

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leptin receptor

decreases expression

tributyltin results in decreased expression of LEPR mRNA

NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549

G

LETM1 domain containing 1

increases expression

tributyltin results in increased expression of LETMD1 mRNA

NCBI chr15:100,360,302...100,377,133
Ensembl chr15:100,366,904...100,377,045

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lectin, galactose binding, soluble 4

increases expression

tributyltin results in increased expression of LGALS4 mRNA

NCBI chr 7:28,533,559...28,541,128
Ensembl chr 7:28,533,279...28,541,133

G

luteinizing hormone beta

decreases secretion
multiple interactions
increases secretion
decreases expression

tributyltin results in decreased secretion of LHB protein
[bisphenol A co-treated with tributyltin] results in increased secretion of LHB protein; Fatty Acids, Omega-3 inhibits the reaction [tributyltin results in decreased expression of LHB protein]; tributyltin inhibits the reaction [Estrogens deficiency results in increased secretion of LHB protein]; tributyltin inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]; tributyltin inhibits the reaction [KISS1 protein results in increased secretion of LHB protein]
tributyltin results in increased secretion of LHB protein
tributyltin results in decreased expression of LHB mRNA; tributyltin results in decreased expression of LHB protein
[tributyltin co-treated with LHB protein] results in decreased secretion of CCL5 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of CCL8 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of CXCL13 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of IL15 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of IL16 protein; [tributyltin co-treated with LHB protein] results in decreased secretion of PDGFAA protein; [tributyltin co-treated with LHB protein] results in increased expression of ASCL1 mRNA; [tributyltin co-treated with LHB protein] results in increased expression of DGAT1 mRNA; [tributyltin co-treated with LHB protein] results in increased expression of FASN mRNA; [tributyltin co-treated with LHB protein] results in increased expression of PLIN1 mRNA; [tributyltin co-treated with LHB protein] results in increased expression of PNPLA2 mRNA; [tributyltin co-treated with LHB protein] results in increased expression of SREBF1 mRNA; [tributyltin co-treated with LHB protein] results in increased secretion of IL18 protein; [tributyltin co-treated with LHB protein] results in increased secretion of IL9 protein

PMID:28161095 PMID:31129395 PMID:32783468 PMID:35430282 PMID:38630605

NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321

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luteinizing hormone/choriogonadotropin receptor

increases expression

tributyltin results in increased expression of LHCGR mRNA; tributyltin results in increased expression of LHCGR protein

NCBI chr17:89,023,812...89,099,487
Ensembl chr17:89,023,909...89,099,418

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lon peptidase 1, mitochondrial

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of LONP1 mRNA

NCBI chr17:56,921,297...56,933,903
Ensembl chr17:56,921,297...56,933,887

G

lysyl oxidase

increases expression

tributyltin results in increased expression of LOX mRNA

NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939

G

lysyl oxidase-like 2

increases expression

tributyltin results in increased expression of LOXL2 mRNA

NCBI chr14:69,846,085...69,933,283
Ensembl chr14:69,846,517...69,933,283

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lysyl oxidase-like 4

decreases expression

tributyltin results in decreased expression of LOXL4 mRNA

NCBI chr19:42,580,718...42,601,326
Ensembl chr19:42,582,421...42,601,252

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lysophosphatidylcholine acyltransferase 3

increases expression

tributyltin results in increased expression of LPCAT3 mRNA

NCBI chr 6:124,639,887...124,681,142
Ensembl chr 6:124,639,990...124,681,381

G

lipin 1

increases expression

tributyltin results in increased expression of LPIN1 mRNA

NCBI chr12:16,585,670...16,697,020
Ensembl chr12:16,585,670...16,696,967

G

lipoprotein lipase

multiple interactions
increases expression

T 0070907 inhibits the reaction [tributyltin results in increased expression of LPL mRNA]; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of LPL mRNA]

PMID:22197818 PMID:23322813 PMID:24513447 PMID:28011154 PMID:29787037

NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100

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leucine-rich repeats and calponin homology (CH) domain containing 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of LRCH2 mRNA

NCBI chr X:146,253,376...146,337,198
Ensembl chr X:146,253,371...146,337,077

G

leucine rich repeat and fibronectin type III domain containing 3

decreases expression

tributyltin results in decreased expression of LRFN3 mRNA

NCBI chr 7:30,054,939...30,062,197
Ensembl chr 7:30,054,914...30,062,197

G

low density lipoprotein receptor-related protein 11

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of LRP11 mRNA

NCBI chr10:7,465,532...7,501,247
Ensembl chr10:7,465,564...7,501,247

G

low density lipoprotein receptor-related protein 2

decreases expression

tributyltin results in decreased expression of LRP2 mRNA

NCBI chr 2:69,254,679...69,416,373
Ensembl chr 2:69,254,684...69,416,409

G

leucine rich repeat containing 1

increases expression

tributyltin results in increased expression of LRRC1 mRNA

NCBI chr 9:77,338,103...77,453,749
Ensembl chr 9:77,338,105...77,452,152

G

leucine rich repeat containing 69

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of LRRC69 mRNA

NCBI chr 4:14,623,622...14,808,379
Ensembl chr 4:14,623,620...14,796,060

G

leucine rich repeat containing 8 family, member B

increases expression

tributyltin results in increased expression of LRRC8B mRNA

NCBI chr 5:105,563,072...105,637,945
Ensembl chr 5:105,563,641...105,637,940

G

leucine rich repeats and death domain containing 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of LRRD1 mRNA

NCBI chr 5:3,895,173...3,916,596
Ensembl chr 5:3,895,173...3,916,596

G

leucine-rich repeats and transmembrane domains 1

increases expression

tributyltin results in increased expression of LRTM1 mRNA

NCBI chr14:28,740,165...28,755,599
Ensembl chr14:28,740,165...28,755,602

G

LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of LSM2 mRNA

NCBI chr17:35,200,830...35,204,867
Ensembl chr17:35,200,838...35,204,867

G

lactotransferrin

increases expression

tributyltin results in increased expression of LTF mRNA

NCBI chr 9:110,848,360...110,871,834
Ensembl chr 9:110,848,339...110,871,835

G

lymphocyte antigen 6 family member D

decreases expression

tributyltin results in decreased expression of LY6D mRNA

NCBI chr15:74,633,905...74,635,416
Ensembl chr15:74,633,905...74,635,469

G

MAF bZIP transcription factor A

decreases expression

tributyltin results in decreased expression of MAFA mRNA

NCBI chr15:75,617,350...75,620,170
Ensembl chr15:75,617,339...75,620,077

G

MAGE family member B18

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of MAGEB18 mRNA

NCBI chr X:91,162,485...91,643,178
Ensembl chr X:91,162,485...91,643,178

G

mitogen-activated protein kinase kinase 3

decreases expression

tributyltin results in decreased expression of MAP2K3 mRNA

NCBI chr11:60,822,880...60,843,637
Ensembl chr11:60,822,859...60,843,637

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions

tributyltin results in increased expression of and results in increased phosphorylation of MAP3K5 protein

NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499

G

mitogen-activated protein kinase kinase kinase 6

decreases expression

tributyltin results in decreased expression of MAP3K6 mRNA

NCBI chr 4:132,965,290...132,980,240
Ensembl chr 4:132,968,129...132,980,240

G

mitogen-activated protein kinase kinase kinase 7

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of MAP3K7 mRNA
tributyltin results in increased expression of MAP3K7 mRNA

NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467

G

mitogen-activated protein kinase kinase kinase kinase 4

decreases expression

tributyltin results in decreased expression of MAP4K4 mRNA

NCBI chr 1:39,939,806...40,065,470
Ensembl chr 1:39,940,073...40,065,470

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation
increases activity
decreases expression
increases expression

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tributyltin results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased activity of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased phosphorylation of MAPK1 protein]; [U 0126 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [tributyltin results in increased activity of MAPK1 protein]; Estradiol promotes the reaction [tributyltin results in increased expression of and results in increased phosphorylation of MAPK1 protein]; tributyltin affects the phosphorylation of and affects the activity of MAPK1 protein; tributyltin results in increased expression of and results in increased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [tributyltin results in increased activity of MAPK1 protein]
tributyltin results in decreased expression of MAPK1 mRNA
tributyltin results in increased expression of MAPK1 protein

PMID:11042092 PMID:18989867 PMID:22223438 PMID:23523586 PMID:23743147 More...

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 12

decreases expression

tributyltin results in decreased expression of MAPK12 mRNA

NCBI chr15:89,014,787...89,025,270
Ensembl chr15:89,014,787...89,024,906

G

mitogen-activated protein kinase 14

increases expression

tributyltin results in increased expression of MAPK14 mRNA

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation
increases activity
increases expression

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tributyltin results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin results in increased phosphorylation of MAPK3 protein]; [U 0126 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [tributyltin results in increased activity of MAPK3 protein]; Estradiol promotes the reaction [tributyltin results in increased expression of and results in increased phosphorylation of MAPK3 protein]; tributyltin affects the phosphorylation of and affects the activity of MAPK3 protein; tributyltin results in increased expression of and results in increased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [tributyltin results in increased activity of MAPK3 protein]
tributyltin results in increased expression of MAPK3 protein

PMID:11042092 PMID:18989867 PMID:22223438 PMID:23523586 PMID:23743147 More...

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

increases phosphorylation

tributyltin results in increased phosphorylation of MAPK8 protein

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

microtubule-associated protein tau

increases cleavage
increases degradation
multiple interactions

tributyltin results in increased cleavage of MAPT protein
tributyltin results in increased degradation of MAPT protein
CAST protein inhibits the reaction [tributyltin results in increased degradation of MAPT protein]

PMID:23743147 PMID:33481012

NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916

G

MBL associated serine protease 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MASP1 mRNA

NCBI chr16:23,261,778...23,340,127
Ensembl chr16:23,268,167...23,339,565

G

melanocortin 2 receptor

multiple interactions

[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of MC2R mRNA

NCBI chr18:68,539,970...68,562,391
Ensembl chr18:68,539,978...68,562,391

G

MAPK regulated corepressor interacting protein 2

increases expression

tributyltin results in increased expression of MCRIP2 mRNA

NCBI chr17:26,082,672...26,087,738
Ensembl chr17:26,082,672...26,087,738

G

mitochondrial calcium uniporter regulator 1

increases expression

tributyltin results in increased expression of MCUR1 mRNA

NCBI chr13:43,691,882...43,714,284
Ensembl chr13:43,691,869...43,713,667

G

malate dehydrogenase 2, NAD (mitochondrial)

increases expression

tributyltin results in increased expression of MDH2 mRNA

NCBI chr 5:135,807,503...135,819,240
Ensembl chr 5:135,807,334...135,819,252

G

malic enzyme 2, NAD(+)-dependent, mitochondrial

increases expression

tributyltin results in increased expression of ME2 mRNA

NCBI chr18:73,898,025...73,949,326
Ensembl chr18:73,902,974...73,948,520

G

malic enzyme 3, NADP(+)-dependent, mitochondrial

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ME3 mRNA

NCBI chr 7:89,281,492...89,503,423
Ensembl chr 7:89,281,600...89,503,567

G

mediator complex subunit 12-like

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of MED12L mRNA

NCBI chr 3:58,912,820...59,225,867
Ensembl chr 3:58,913,246...59,226,103

G

mediator complex subunit 13

increases expression

tributyltin results in increased expression of MED13 mRNA

NCBI chr11:86,157,859...86,248,422
Ensembl chr11:86,157,859...86,248,428

G

mediator complex subunit 18

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MED18 mRNA

NCBI chr 4:132,186,040...132,191,232
Ensembl chr 4:132,186,042...132,191,232

G

mediator complex subunit 29

decreases expression

tributyltin results in decreased expression of MED29 mRNA

NCBI chr 7:28,084,667...28,092,126
Ensembl chr 7:28,085,571...28,092,133

G

mesenchyme homeobox 1

increases expression

tributyltin results in increased expression of MEOX1 mRNA

NCBI chr11:101,768,336...101,785,309
Ensembl chr11:101,768,336...101,785,200

G

meprin 1 beta

increases expression

tributyltin results in increased expression of MEP1B mRNA

NCBI chr18:21,205,401...21,233,256
Ensembl chr18:21,194,980...21,233,256

G

mesoderm posterior 1

decreases expression

tributyltin results in decreased expression of MESP1 mRNA

NCBI chr 7:79,441,989...79,443,338
Ensembl chr 7:79,441,989...79,443,536

G

methyltransferase 1, tRNA methylguanosine

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of METTL1 mRNA

NCBI chr10:126,877,287...126,882,234
Ensembl chr10:126,877,283...126,882,234

G

mannoside acetylglucosaminyltransferase 4, isoenzyme A

increases expression

tributyltin results in increased expression of MGAT4A mRNA

NCBI chr 1:37,478,421...37,580,599
Ensembl chr 1:37,478,421...37,580,097

G

monoglyceride lipase

increases expression

tributyltin results in increased expression of MGLL mRNA

NCBI chr 6:88,701,397...88,805,342
Ensembl chr 6:88,701,394...88,805,342

G

O-6-methylguanine-DNA methyltransferase

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MGMT mRNA

NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995

G

MIB E3 ubiquitin protein ligase 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of MIB1 mRNA

NCBI chr18:10,725,523...10,822,969
Ensembl chr18:10,725,548...10,818,704

G

microtubule associated monooxygenase, calponin and LIM domain containing 1

increases expression

tributyltin results in increased expression of MICAL1 mRNA

NCBI chr10:41,351,693...41,363,026
Ensembl chr10:41,352,310...41,363,028

G

MHC I like leukocyte 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of MICB mRNA

NCBI chr 7:18,573,878...18,603,621
Ensembl chr 7:18,573,891...18,599,327

G

mitotic spindle positioning

increases expression

tributyltin results in increased expression of MISP mRNA

NCBI chr10:79,656,853...79,666,286
Ensembl chr10:79,656,823...79,666,324

G

antigen identified by monoclonal antibody Ki 67

decreases expression
multiple interactions

tributyltin results in decreased expression of MKI67 protein
Fatty Acids, Omega-3 inhibits the reaction [tributyltin results in decreased expression of MKI67 protein]

NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090

G

membrane metallo endopeptidase

increases expression

tributyltin results in increased expression of MME mRNA

NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451

G

matrix metallopeptidase 12

decreases expression

tributyltin results in decreased expression of MMP12 mRNA

NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499

G

matrix metallopeptidase 13

increases expression

tributyltin results in increased expression of MMP13 mRNA

NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331

G

matrix metallopeptidase 2

increases expression

tributyltin results in increased expression of MMP2 protein

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 8

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MMP8 mRNA

NCBI chr 9:7,558,430...7,568,487
Ensembl chr 9:7,558,457...7,568,486

G

matrix metallopeptidase 9

multiple interactions

tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP9 mRNA]

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

monoacylglycerol O-acyltransferase 2

increases expression

tributyltin results in increased expression of MOGAT2 mRNA

NCBI chr 7:98,868,291...98,887,818
Ensembl chr 7:98,868,291...98,887,826

G

monooxygenase, DBH-like 1

decreases expression

tributyltin results in decreased expression of MOXD1 mRNA

NCBI chr10:24,099,415...24,178,681
Ensembl chr10:24,099,415...24,178,688

G

mitochondrial pyruvate carrier 2

increases expression

tributyltin results in increased expression of MPC2 mRNA

NCBI chr 1:165,288,829...165,308,787
Ensembl chr 1:165,288,206...165,308,783

G

myeloperoxidase

increases activity

tributyltin results in increased activity of MPO protein

PMID:28161095 PMID:29908848 PMID:30172001

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

metallophosphoesterase 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MPPE1 mRNA

NCBI chr18:67,358,119...67,378,901
Ensembl chr18:67,358,114...67,378,901

G

Mpv17 transgene, kidney disease mutant-like

increases expression
multiple interactions

tributyltin results in increased expression of MPV17L mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of MPV17L mRNA

NCBI chr16:13,721,025...13,767,483
Ensembl chr16:13,721,025...13,767,483

G

melanocortin 2 receptor accessory protein

increases expression

tributyltin results in increased expression of MRAP mRNA

NCBI chr16:90,535,095...90,546,673
Ensembl chr16:90,535,095...90,546,673

G

mitochondrial ribosomal protein L18

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MRPL18 mRNA

NCBI chr17:13,130,232...13,136,674
Ensembl chr17:13,130,236...13,135,232

G

mitochondrial ribosomal protein L33

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MRPL33 mRNA

NCBI chr 5:31,771,295...31,779,988
Ensembl chr 5:31,754,279...31,821,728

G

mitochondrial ribosomal protein S33

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of MRPS33 mRNA
tributyltin results in increased expression of MRPS33 mRNA

NCBI chr 6:39,778,738...39,787,870
Ensembl chr 6:39,778,738...39,787,922

G

membrane-spanning 4-domains, subfamily A, member 8A

increases expression

tributyltin results in increased expression of MS4A8A mRNA

NCBI chr19:11,044,835...11,058,467
Ensembl chr19:11,044,835...11,058,466

G

macrophage stimulating 1 (hepatocyte growth factor-like)

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MST1 mRNA

NCBI chr 9:107,957,607...107,962,226
Ensembl chr 9:107,957,635...107,962,202

G

msh homeobox 1

multiple interactions
decreases expression

Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of MSX1 mRNA]

NCBI chr 5:37,977,835...37,981,929
Ensembl chr 5:37,977,829...37,981,927

G

ATP synthase 6, mitochondrial

increases response to substance

ATP6 gene mutant form results in increased susceptibility to tributyltin

NCBI chr MT:7,927...8,607
Ensembl chr MT:7,927...8,607

G

ATP synthase 8, mitochondrial

decreases expression

tributyltin results in decreased expression of ATP8 mRNA

NCBI chr MT:7,766...7,969
Ensembl chr MT:7,766...7,969

G

metallothionein 1

decreases expression

tributyltin results in decreased expression of MT1 mRNA

NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955

G

metallothionein 2

decreases expression

tributyltin results in decreased expression of MT2 mRNA

NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196

G

methylenetetrahydrofolate reductase

decreases expression

tributyltin results in decreased expression of MTHFR mRNA

NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008

G

melatonin receptor 1A

decreases expression

tributyltin results in decreased expression of MTNR1A mRNA

NCBI chr 8:45,522,144...45,542,270
Ensembl chr 8:45,522,174...45,541,543

G

mechanistic target of rapamycin kinase

decreases phosphorylation
decreases expression

tributyltin results in decreased phosphorylation of MTOR protein
tributyltin results in decreased expression of MTOR

PMID:20371977 PMID:26961604

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

G

myotrophin

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MTPN mRNA

NCBI chr 6:35,485,759...35,516,823
Ensembl chr 6:35,485,841...35,516,823

G

microsomal triglyceride transfer protein

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of MTTP mRNA

NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729

G

major urinary protein 1

decreases expression

tributyltin results in decreased expression of MUP1 mRNA

NCBI chr 4:60,454,011...60,457,959
Ensembl chr 4:60,454,011...60,457,959

G

major urinary protein 12

decreases expression

tributyltin results in decreased expression of MUP12 mRNA

NCBI chr 4:60,693,360...60,697,415
Ensembl chr 4:60,693,382...60,697,325

G

major urinary protein 19

increases expression

tributyltin results in increased expression of MUP19 mRNA

NCBI chr 4:61,696,561...61,700,597
Ensembl chr 4:61,696,561...61,700,506

G

major urinary protein 2

increases expression

tributyltin results in increased expression of MUP2 mRNA

NCBI chr 4:60,135,913...60,139,977
Ensembl chr 4:60,135,932...60,154,289

G

MAX dimerization protein 1

increases expression

tributyltin results in increased expression of MXD1 mRNA

NCBI chr 6:86,624,026...86,646,099
Ensembl chr 6:86,624,024...86,646,143

G

Max dimerization protein 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of MXD4 mRNA

NCBI chr 5:34,331,231...34,345,076
Ensembl chr 5:34,331,227...34,345,064

G

myeloid differentiation primary response gene 88

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of MYD88 mRNA

NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477

G

myosin XVB

increases expression

tributyltin results in increased expression of MYO15B mRNA

NCBI chr11:115,749,002...115,783,443
Ensembl chr11:115,749,232...115,783,429

G

myosin VC

increases expression

tributyltin results in increased expression of MYO5C mRNA

NCBI chr 9:75,139,252...75,212,733
Ensembl chr 9:75,139,302...75,212,733

G

myosin VIIB

increases expression

tributyltin results in increased expression of MYO7B mRNA

NCBI chr18:32,092,287...32,169,984
Ensembl chr18:32,092,287...32,170,014

G

nascent polypeptide-associated complex alpha polypeptide

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of NACA mRNA

NCBI chr10:127,869,144...127,884,506
Ensembl chr10:127,871,444...127,884,506

G

alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)

increases activity

tributyltin results in increased activity of NAGLU protein

NCBI chr11:100,960,918...100,968,483
Ensembl chr11:100,960,838...100,968,498

G

NLR family, apoptosis inhibitory protein 1

increases expression

tributyltin results in increased expression of NAIP1 mRNA

NCBI chr13:100,544,272...100,589,372
Ensembl chr13:100,544,272...100,589,377

G

nicotinamide phosphoribosyltransferase

increases expression

tributyltin results in increased expression of NAMPT mRNA

NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348

G

N-acetyltransferase 8 (GCN5-related) family member 5

decreases expression

tributyltin results in decreased expression of NAT8F5 mRNA

NCBI chr 6:85,794,200...85,797,954
Ensembl chr 6:85,794,200...85,797,954

G

neurobeachin-like 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of NBEAL2 mRNA

NCBI chr 9:110,453,857...110,483,229
Ensembl chr 9:110,453,857...110,483,229

G

neural cell adhesion molecule 1

multiple interactions
affects localization

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tributyltin affects the localization of NCAM1 protein]

NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225

G

non-SMC condensin II complex, subunit H2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of NCAPH2 mRNA

NCBI chr15:89,239,920...89,257,030
Ensembl chr15:89,239,922...89,257,029

G

nuclear receptor co-repressor 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of NCOR1 mRNA

NCBI chr11:62,207,132...62,348,200
Ensembl chr11:62,207,252...62,349,367

G

nudE neurodevelopment protein 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of NDE1 mRNA

NCBI chr16:13,981,139...14,010,792
Ensembl chr16:13,981,139...14,010,792

G

N-myc downstream regulated gene 1

increases expression

tributyltin results in increased expression of NDRG1 mRNA

NCBI chr15:66,801,167...66,841,490
Ensembl chr15:66,801,167...66,841,489

G

Ndufa4, mitochondrial complex associated

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of NDUFA4 mRNA

NCBI chr 6:11,900,371...11,907,449
Ensembl chr 6:11,900,291...11,907,496

G

NADH:ubiquinone oxidoreductase subunit A5

increases expression

tributyltin results in increased expression of NDUFA5 mRNA

NCBI chr 6:24,518,661...24,527,689
Ensembl chr 6:24,518,665...24,528,012

G

NADH:ubiquinone oxidoreductase core subunit S1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of NDUFS1 mRNA

NCBI chr 1:63,182,751...63,215,981
Ensembl chr 1:63,182,755...63,215,992

G

neural precursor cell expressed, developmentally down-regulated gene 4-like

decreases expression

tributyltin results in decreased expression of NEDD4L mRNA

NCBI chr18:65,017,551...65,350,888
Ensembl chr18:65,020,776...65,350,899

G

neurofilament, heavy polypeptide

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [tributyltin results in decreased expression of NEFH protein]

NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064

G

neurofilament, medium polypeptide

increases degradation
multiple interactions

tributyltin results in increased degradation of NEFM protein
CAST protein inhibits the reaction [tributyltin results in increased degradation of NEFM protein]

NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295

G

nei like 3 (E. coli)

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of NEIL3 mRNA

NCBI chr 8:54,039,902...54,092,100
Ensembl chr 8:54,039,902...54,092,100

G

neuraminidase 3

decreases expression

tributyltin results in decreased expression of NEU3 mRNA

NCBI chr 7:99,460,646...99,477,579
Ensembl chr 7:99,460,646...99,477,624

G

neuralized E3 ubiquitin protein ligase 3

increases expression

tributyltin results in increased expression of NEURL3 mRNA

NCBI chr 1:36,303,683...36,313,755
Ensembl chr 1:36,303,678...36,313,760

G

neurofibromin 1

increases expression

tributyltin results in increased expression of NF1 mRNA

NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438

G

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

multiple interactions

Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]

NCBI chr18:80,649,418...80,756,286
Ensembl chr18:80,649,420...80,756,286

G

nuclear factor, erythroid derived 2, like 2

multiple interactions
increases expression
increases localization

Acetylcysteine inhibits the reaction [tributyltin results in increased expression of NFE2L2 protein]; Phycocyanin inhibits the reaction [tributyltin results in increased expression of NFE2L2 protein]
PRKCD gene mutant form promotes the reaction [tributyltin affects the localization of and results in increased activity of NFE2L2 protein]
tributyltin results in increased localization of NFE2L2 protein

PMID:24055800 PMID:25895139 PMID:26079211 PMID:28707438 PMID:36858641

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor, interleukin 3, regulated

decreases expression

tributyltin results in decreased expression of NFIL3 mRNA

NCBI chr13:53,121,245...53,136,914
Ensembl chr13:53,121,245...53,135,109

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

increases expression

tributyltin results in increased expression of NFKB1 protein

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

affects expression
decreases expression

tributyltin affects the expression of NFKBIA mRNA
tributyltin results in decreased expression of NFKBIA protein

PMID:27678064 PMID:30172001

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

neuronal guanine nucleotide exchange factor

increases expression

tributyltin results in increased expression of NGEF mRNA

NCBI chr 1:87,404,551...87,501,661
Ensembl chr 1:87,404,556...87,501,592

G

NIPA-like domain containing 2

increases expression

tributyltin results in increased expression of NIPAL2 mRNA

NCBI chr15:34,572,942...34,679,739
Ensembl chr15:34,572,945...34,679,358

G

NME/NM23 nucleoside diphosphate kinase 2

multiple interactions
decreases expression

Tretinoin promotes the reaction [tributyltin results in decreased expression of NME2 protein]

NCBI chr11:93,840,640...93,847,082
Ensembl chr11:93,840,640...93,847,085

G

nocturnin

increases expression

tributyltin results in increased expression of NOCT mRNA

NCBI chr 3:51,131,868...51,159,075
Ensembl chr 3:51,131,868...51,159,065

G

nucleolar protein 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of NOL4 mRNA

NCBI chr18:22,826,209...23,174,926
Ensembl chr18:22,826,238...23,174,710

G

nitric oxide synthase 1, neuronal

multiple interactions
decreases activity

CALM1 protein inhibits the reaction [tributyltin results in decreased activity of NOS1 protein]; tributyltin inhibits the reaction [CALM1 protein binds to NOS1 protein]

NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905

G

nitric oxide synthase 1 (neuronal) adaptor protein

decreases expression

tributyltin results in decreased expression of NOS1AP mRNA

NCBI chr 1:170,143,039...170,417,371
Ensembl chr 1:170,130,237...170,417,430

G

nitric oxide synthase 2, inducible

increases expression

tributyltin results in increased expression of NOS2 protein

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

decreases expression
multiple interactions

tributyltin results in decreased expression of NOS3 protein
tributyltin results in decreased expression of and results in increased phosphorylation of NOS3 protein

PMID:26873547 PMID:34902535

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

neuronal PAS domain protein 2

decreases expression

tributyltin results in decreased expression of NPAS2 mRNA

NCBI chr 1:39,233,013...39,402,321
Ensembl chr 1:39,232,812...39,402,317

G

neuropeptide Y

decreases expression

tributyltin results in decreased expression of NPY protein

NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487

G

nuclear receptor subfamily 1, group D, member 1

increases expression

tributyltin results in increased expression of NR1D1 mRNA

NCBI chr11:98,658,758...98,666,233
Ensembl chr11:98,658,758...98,666,159

G

nuclear receptor subfamily 1, group D, member 2

increases expression

tributyltin results in increased expression of NR1D2 mRNA

NCBI chr14:4,230,549...4,265,639
Ensembl chr14:4,230,569...4,265,642

G

nuclear receptor subfamily 1, group H, member 3

multiple interactions
increases expression

tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]
tributyltin results in increased expression of NR1H3 mRNA

PMID:23428407 PMID:24848799 PMID:25932594 PMID:28011154

NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

tributyltin binds to and results in increased activity of NR1I2 protein
tributyltin binds to and results in decreased activity of NR1I2 protein

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

tributyltin results in decreased expression of NR4A1 mRNA

NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676

G

nuclear receptor subfamily 5, group A, member 1

decreases expression

tributyltin results in decreased expression of NR5A1 mRNA; tributyltin results in decreased expression of NR5A1 protein

NCBI chr 2:38,582,668...38,604,554
Ensembl chr 2:38,582,668...38,604,554

G

nardilysin convertase

decreases expression

tributyltin results in decreased expression of NRDC mRNA

NCBI chr 4:108,857,852...108,918,974
Ensembl chr 4:108,857,852...108,918,974

G

neuronal regeneration related protein

increases expression

tributyltin results in increased expression of NREP mRNA

NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082

G

NSE3 homolog, SMC5-SMC6 complex component

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of NSMCE3 mRNA

NCBI chr 7:64,521,430...64,522,788
Ensembl chr 7:64,516,800...64,522,745

G

odontogenic, ameloblast asssociated

increases expression

tributyltin results in increased expression of ODAM mRNA

NCBI chr 5:88,032,869...88,042,668
Ensembl chr 5:88,032,888...88,042,033

G

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

increases expression

tributyltin results in increased expression of OGDH mRNA

NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642

G

8-oxoguanine DNA-glycosylase 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OGG1 mRNA

NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029

G

one cut domain, family member 1

increases expression

tributyltin results in increased expression of ONECUT1 mRNA

NCBI chr 9:74,769,203...74,796,930
Ensembl chr 9:74,769,203...74,799,063

G

olfactory receptor family 10 subfamily A member 48

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR10A48 mRNA

NCBI chr 7:108,424,272...108,425,204
Ensembl chr 7:108,424,272...108,425,204

G

olfactory receptor family 13 subfamily C member 3

decreases expression
multiple interactions

tributyltin results in decreased expression of OR13C3C mRNA
[bisphenol A co-treated with tributyltin] results in decreased expression of OR13C3 mRNA

NCBI chr 4:52,855,558...52,856,511
Ensembl chr 4:52,852,154...52,859,236

G

olfactory receptor family 13 subfamily F member 5

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of OR13F5 mRNA

NCBI chr 4:52,825,399...52,826,358
Ensembl chr 4:52,814,604...52,828,269

G

olfactory receptor family 2 subfamily T member 26

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR2T26 mRNA

NCBI chr11:49,039,086...49,040,039
Ensembl chr11:49,033,101...49,041,280

G

olfactory receptor family 51 subfamily A member 7

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR51A7 mRNA

NCBI chr 7:102,614,309...102,615,247
Ensembl chr 7:102,611,867...102,624,367

G

olfactory receptor family 52 subfamily P member 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR52P1 mRNA

NCBI chr 7:104,266,864...104,267,853
Ensembl chr 7:104,263,162...104,270,810

G

olfactory receptor family 5 subfamily AU member 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR5AU1 mRNA

NCBI chr14:52,272,631...52,273,566
Ensembl chr14:52,271,419...52,279,916

G

olfactory receptor family 5 subfamily T member 5

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR5T5B mRNA

NCBI chr 2:86,612,889...86,617,135
Ensembl chr 2:86,612,823...86,617,960

G

olfactory receptor family 6 subfamily F member 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of OR6F1 mRNA

NCBI chr 7:85,970,232...85,971,158
Ensembl chr 7:85,967,426...85,974,838

G

oxysterol binding protein

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of OSBP mRNA

NCBI chr19:11,943,208...11,971,478
Ensembl chr19:11,943,305...11,971,476

G

oxysterol binding protein-like 3

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of OSBPL3 mRNA
tributyltin results in increased expression of OSBPL3 mRNA

PMID:31129395 PMID:31939706

NCBI chr 6:50,270,307...50,433,334
Ensembl chr 6:50,270,310...50,433,181

G

oxidative stress induced growth inhibitor family member 2

multiple interactions
decreases expression

[bisphenol A co-treated with tributyltin] results in decreased expression of OSGIN2 mRNA
tributyltin results in decreased expression of OSGIN2 mRNA

NCBI chr 4:15,996,354...16,015,266
Ensembl chr 4:15,997,121...16,013,888

G

orthodenticle homeobox 2

increases expression

tributyltin results in increased expression of OTX2 mRNA

NCBI chr14:48,894,238...48,905,101
Ensembl chr14:48,895,134...48,911,276

G

3-oxoacid CoA transferase 1

increases expression

tributyltin results in increased expression of OXCT1 mRNA

NCBI chr15:4,055,910...4,184,826
Ensembl chr15:4,055,865...4,184,826

G

purinergic receptor P2Y, G-protein coupled 10

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of P2RY10 mRNA

NCBI chr X:106,132,098...106,148,580
Ensembl chr X:106,132,098...106,148,580

G

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III

increases expression

tributyltin results in increased expression of P4HA3 mRNA

NCBI chr 7:99,934,637...99,968,908
Ensembl chr 7:99,934,727...99,968,906

G

proton activated chloride channel 1

increases expression

tributyltin results in increased expression of PACC1 mRNA

NCBI chr 1:191,058,099...191,083,481
Ensembl chr 1:191,058,109...191,083,111

G

pantothenate kinase 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PANK4 mRNA

NCBI chr 4:155,048,580...155,065,395
Ensembl chr 4:155,048,580...155,065,395

G

progestin and adipoQ receptor family member IV

increases expression

tributyltin results in increased expression of PAQR4 mRNA

NCBI chr17:23,955,160...23,959,873
Ensembl chr17:23,955,160...23,959,841

G

par-6 family cell polarity regulator beta

increases expression

tributyltin results in increased expression of PARD6B mRNA

NCBI chr 2:167,922,924...167,943,123
Ensembl chr 2:167,922,924...167,943,123

G

prostate androgen-regulated mucin-like protein 1

increases expression

tributyltin results in increased expression of PARM1 mRNA

NCBI chr 5:91,665,559...91,771,870
Ensembl chr 5:91,665,474...91,774,753

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions
increases cleavage

[bisphenol A co-treated with tributyltin] results in increased expression of PARP1 mRNA
DFFB protein promotes the reaction [tributyltin results in increased cleavage of PARP1 protein]

PMID:31129395 PMID:31401084

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

prostate and testis expressed 4

decreases expression

tributyltin results in decreased expression of PATE4 mRNA

NCBI chr 9:35,518,387...35,523,164
Ensembl chr 9:35,518,389...35,523,237

G

phosphoenolpyruvate carboxykinase 1, cytosolic

increases expression

tributyltin results in increased expression of PCK1 mRNA

PMID:23428407 PMID:24848799

NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

increases expression

tributyltin results in increased expression of PCK2 protein

NCBI chr14:55,777,721...55,787,477
Ensembl chr14:55,777,723...55,788,699

G

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PCMTD2 mRNA

NCBI chr 2:181,471,952...181,499,253
Ensembl chr 2:181,479,647...181,499,254

G

proprotein convertase subtilisin/kexin type 1 inhibitor

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of PCSK1N mRNA

NCBI chr X:7,786,061...7,790,649
Ensembl chr X:7,786,061...7,790,649

G

proprotein convertase subtilisin/kexin type 4

increases expression

tributyltin results in increased expression of PCSK4 mRNA

NCBI chr10:80,157,117...80,165,583
Ensembl chr10:80,157,117...80,165,332

G

pyruvate carboxylase

increases expression

tributyltin results in increased expression of PCX mRNA

NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780

G

prenylcysteine oxidase 1

increases expression

tributyltin results in increased expression of PCYOX1 mRNA

NCBI chr 6:86,362,988...86,374,132
Ensembl chr 6:86,362,988...86,374,136

G

programmed cell death 7

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PDCD7 mRNA

NCBI chr 9:65,253,350...65,266,925
Ensembl chr 9:65,253,386...65,266,925

G

phosphodiesterase 4D, cAMP specific

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of PDE4D mRNA

NCBI chr13:108,790,711...110,092,503
Ensembl chr13:108,586,482...110,089,995

G

pyruvate dehydrogenase (lipoamide) beta

increases expression

tributyltin results in increased expression of PDHB mRNA

NCBI chr14:14,296,470...14,303,782
Ensembl chr14:14,296,748...14,303,777

G

pyruvate dehydrogenase kinase, isoenzyme 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of PDK2 mRNA

NCBI chr11:94,917,084...94,932,197
Ensembl chr11:94,917,084...94,932,180

G

pyruvate dehydrogenase kinase, isoenzyme 4

decreases expression

tributyltin results in decreased expression of PDK4 mRNA

NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309

G

PDS5 cohesin associated factor A

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of PDS5A mRNA

NCBI chr 5:65,763,062...65,855,579
Ensembl chr 5:65,763,064...65,855,616

G

PDS5 cohesin associated factor B

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PDS5B mRNA

NCBI chr 5:150,597,178...150,734,174
Ensembl chr 5:150,597,204...150,734,155

G

pancreatic and duodenal homeobox 1

multiple interactions
decreases expression

[bisphenol A co-treated with tributyltin] results in decreased expression of PDX1 mRNA
tributyltin results in decreased expression of PDX1 mRNA

PMID:31129395 PMID:35563431

NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658

G

period circadian clock 2

increases expression

tributyltin results in increased expression of PER2 mRNA

NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046

G

period circadian clock 3

increases expression

tributyltin results in increased expression of PER3 mRNA

NCBI chr 4:151,081,475...151,129,167
Ensembl chr 4:151,088,109...151,129,122

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

increases expression

tributyltin results in increased expression of PFKFB4 mRNA

NCBI chr 9:108,817,336...108,861,302
Ensembl chr 9:108,820,846...108,861,296

G

phosphoglucomutase 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PGM3 mRNA

NCBI chr 9:86,423,997...86,453,927
Ensembl chr 9:86,436,430...86,453,895

G

phosphate regulating endopeptidase homolog, X-linked

multiple interactions

tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of PHEX mRNA]

NCBI chr X:155,945,071...156,198,282
Ensembl chr X:155,945,071...156,198,308

G

phosphatidylinositol glycan anchor biosynthesis, class A

increases expression

tributyltin results in increased expression of PIGA mRNA

NCBI chr X:163,202,814...163,216,912
Ensembl chr X:163,202,783...163,216,912

G

phosphatidylinositol glycan anchor biosynthesis, class O

decreases expression

tributyltin results in decreased expression of PIGO mRNA

NCBI chr 4:43,016,964...43,026,369
Ensembl chr 4:43,017,635...43,025,819

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

increases expression
decreases expression

tributyltin results in increased expression of PIK3CA mRNA
tributyltin results in decreased expression of PIK3CA mRNA

PMID:26314263 PMID:27678064

NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

increases expression

tributyltin results in increased expression of PIK3CB mRNA

NCBI chr 9:98,920,455...99,022,264
Ensembl chr 9:98,918,707...99,022,674

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

increases expression

tributyltin results in increased expression of PIK3CG mRNA

NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658

G

paired-like homeodomain transcription factor 3

decreases expression

tributyltin results in decreased expression of PITX3 mRNA

NCBI chr19:46,123,720...46,136,764
Ensembl chr19:46,124,124...46,136,765

G

pyruvate kinase, muscle

increases expression

tributyltin results in increased expression of PKM mRNA

NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658

G

plakophilin 3

increases expression

tributyltin results in increased expression of PKP3 mRNA

NCBI chr 7:140,658,202...140,670,424
Ensembl chr 7:140,658,131...140,670,423

G

placenta-specific 8

increases expression

tributyltin results in increased expression of PLAC8 mRNA

NCBI chr 5:100,699,455...100,720,119
Ensembl chr 5:100,701,591...100,720,111

G

phospholipase C, beta 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PLCB4 mRNA

NCBI chr 2:135,500,523...135,856,522
Ensembl chr 2:135,500,931...135,856,513

G

phospholipase C, epsilon 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PLCE1 mRNA

NCBI chr19:38,469,438...38,773,549
Ensembl chr19:38,469,557...38,773,474

G

phospholipase C, gamma 1

decreases expression

tributyltin results in decreased expression of PLCG1 mRNA

NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680

G

phospholipase C, gamma 2

decreases expression

tributyltin results in decreased expression of PLCG2 mRNA

NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881

G

phospholipase D family member 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of PLD3 mRNA

NCBI chr 7:27,231,090...27,252,511
Ensembl chr 7:27,231,425...27,252,643

G

pleckstrin homology domain containing, family H (with MyTH4 domain) member 1

increases expression

tributyltin results in increased expression of PLEKHH1 mRNA

NCBI chr12:79,075,937...79,128,429
Ensembl chr12:79,075,937...79,128,429

G

perilipin 1

increases expression
multiple interactions

tributyltin results in increased expression of PLIN1 mRNA
[tributyltin co-treated with LHB protein] results in increased expression of PLIN1 mRNA

PMID:23428407 PMID:25777084 PMID:25932594 PMID:30027469 PMID:38630605

NCBI chr 7:79,370,912...79,382,652
Ensembl chr 7:79,369,966...79,382,651

G

perilipin 2

increases expression

tributyltin results in increased expression of PLIN2 mRNA

NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297

G

proteolipid protein 2

increases expression

tributyltin results in increased expression of PLP2 mRNA

NCBI chr X:7,534,180...7,537,629
Ensembl chr X:7,534,180...7,537,629

G

phospholipid phosphatase 1

decreases expression

tributyltin results in decreased expression of PPAP2A mRNA

NCBI chr13:112,937,311...113,004,428
Ensembl chr13:112,937,326...113,004,428

G

plastin 1 (I-isoform)

increases expression

tributyltin results in increased expression of PLS1 mRNA

NCBI chr 9:95,634,695...95,727,359
Ensembl chr 9:95,634,695...95,727,364

G

plexin domain containing 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PLXDC2 mRNA

NCBI chr 2:16,360,551...16,765,941
Ensembl chr 2:16,361,115...16,760,650

G

paroxysmal nonkinesiogenic dyskinesia

decreases expression

tributyltin results in decreased expression of PNKD mRNA

NCBI chr 1:74,323,757...74,392,851
Ensembl chr 1:74,324,089...74,392,853

G

poly(A)-specific ribonuclease (PARN)-like domain containing 1

increases expression

tributyltin results in increased expression of PNLDC1 mRNA

NCBI chr17:13,107,610...13,129,489
Ensembl chr17:13,107,616...13,129,117

G

PNMA family member 8A

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PNMA8A mRNA

NCBI chr 7:16,683,325...16,698,532
Ensembl chr 7:16,693,604...16,698,532

G

patatin-like phospholipase domain containing 2

multiple interactions

[tributyltin co-treated with LHB protein] results in increased expression of PNPLA2 mRNA

NCBI chr 7:141,035,101...141,040,656
Ensembl chr 7:141,035,111...141,040,656

G

patatin-like phospholipase domain containing 8

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PNPLA8 mRNA

NCBI chr12:44,315,916...44,362,718
Ensembl chr12:44,268,153...44,369,315

G

POC1 centriolar protein B

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of POC1B mRNA

NCBI chr10:98,942,918...99,033,936
Ensembl chr10:98,942,898...99,033,936

G

cytochrome p450 oxidoreductase

increases expression

tributyltin results in increased expression of POR mRNA

NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180

G

POU domain class 5, transcription factor 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of POU5F2 mRNA

NCBI chr13:78,173,021...78,174,415
Ensembl chr13:78,173,021...78,174,414

G

peroxisome proliferator activated receptor alpha

increases expression

tributyltin results in increased expression of PPARA mRNA

PMID:23322813 PMID:30027469

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

peroxisome proliferator activated receptor gamma

increases expression
increases activity
multiple interactions
affects binding

tributyltin results in increased expression of PPARG mRNA; tributyltin results in increased expression of PPARG protein
tributyltin results in increased activity of PPARG protein
[triphenyltin chloride co-treated with tributyltin co-treated with dibutyldichlorotin] results in increased expression of PPARG protein; PPARG protein promotes the reaction [tributyltin binds to and results in increased activity of PPARG protein]; T 0070907 inhibits the reaction [tributyltin binds to and results in increased activity of PPARG protein]; T 0070907 inhibits the reaction [tributyltin results in increased expression of PPARG mRNA]; tributyltin binds to and results in increased activity of PPARG protein; tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA alternative form]
T 0070907 inhibits the reaction [tributyltin results in increased expression of PPARG mRNA]; tributyltin binds to and results in increased activity of PPARG protein; tributyltin inhibits the reaction [GW 1929 binds to PPARG protein]; tributyltin inhibits the reaction [Rosiglitazone binds to PPARG protein]; tributyltin inhibits the reaction [triphenyltin chloride binds to PPARG protein]
tributyltin binds to PPARG protein
[bisphenol A co-treated with tributyltin] results in increased expression of PPARG protein

PMID:19497422 PMID:21622945 PMID:22197818 PMID:23322813 PMID:24155963 More...

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

pro-platelet basic protein

decreases expression

tributyltin results in decreased expression of PPBP mRNA

PMID:31129395 PMID:31939706

NCBI chr 5:90,916,377...90,917,922
Ensembl chr 5:90,916,377...90,917,922

G

protein phosphatase 1B, magnesium dependent, beta isoform

increases expression

tributyltin results in increased expression of PPM1B mRNA

NCBI chr17:85,264,169...85,331,420
Ensembl chr17:85,264,169...85,331,419

G

protein phosphatase 1, regulatory subunit 3C

decreases expression

tributyltin results in decreased expression of PPP1R3C mRNA

NCBI chr19:36,709,131...36,714,004
Ensembl chr19:36,709,131...36,714,053

G

protein phosphatase 1, regulatory subunit 8

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PPP1R8 mRNA

NCBI chr 4:132,554,235...132,570,480
Ensembl chr 4:132,554,240...132,570,480

G

protein phosphatase 2, regulatory subunit B', alpha

increases expression

tributyltin results in increased expression of PPP2R5A mRNA

NCBI chr 1:191,084,178...191,129,238
Ensembl chr 1:191,084,172...191,135,469

G

protein phosphatase 4 regulatory subunit 3A

increases expression

tributyltin results in increased expression of PPP4R3A mRNA

NCBI chr12:101,005,668...101,051,721
Ensembl chr12:101,005,668...101,049,961

G

peptidylprolyl isomerase domain and WD repeat containing 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PPWD1 mRNA

NCBI chr13:104,340,102...104,365,378
Ensembl chr13:104,341,632...104,365,351

G

PRAME like 15

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of PRAMEF20 mRNA

NCBI chr 4:144,099,330...144,104,503
Ensembl chr 4:144,099,330...144,104,530

G

PR domain containing 16

affects methylation
increases expression

tributyltin affects the methylation of PRDM16 gene
tributyltin results in increased expression of PRDM16 mRNA

PMID:28011154 PMID:31939706

NCBI chr 4:154,400,579...154,721,851
Ensembl chr 4:154,400,582...154,721,330

G

protein kinase C, alpha

decreases expression

tributyltin results in decreased expression of PRKCA mRNA

NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754

G

protein kinase C, beta

increases expression

tributyltin results in increased expression of PRKCB mRNA

NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625

G

protein kinase C, delta

multiple interactions
decreases response to substance

PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BAD protein modified form]; PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BCL2 protein]; PRKCD gene mutant form inhibits the reaction [tributyltin results in decreased expression of BCL2L1 protein]; PRKCD gene mutant form inhibits the reaction [tributyltin results in increased expression of BAX protein]; PRKCD gene mutant form inhibits the reaction [tributyltin results in increased expression of CASP3 protein modified form]; PRKCD gene mutant form promotes the reaction [tributyltin affects the localization of and results in increased activity of NFE2L2 protein]; PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLC mRNA]; PRKCD gene mutant form promotes the reaction [tributyltin results in increased expression of GCLM mRNA]
PRKCD gene mutant form results in decreased susceptibility to tributyltin

NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167

G

protein kinase D1

increases phosphorylation

tributyltin results in increased phosphorylation of PRKD1 protein

NCBI chr12:50,388,009...50,696,075
Ensembl chr12:50,388,014...50,695,881

G

protein kinase D3

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PRKD3 mRNA

NCBI chr17:79,256,834...79,328,245
Ensembl chr17:79,256,834...79,328,245

G

protein C

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of PROC mRNA

NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623

G

prominin 1

increases expression

tributyltin results in increased expression of PROM1 mRNA

NCBI chr 5:44,150,963...44,260,850
Ensembl chr 5:44,150,962...44,259,374

G

proline rich 11

increases expression

tributyltin results in increased expression of PRR11 mRNA

NCBI chr11:86,979,982...86,999,540
Ensembl chr11:86,979,979...86,999,534

G

proline rich 15-like

increases expression

tributyltin results in increased expression of PRR15L mRNA

NCBI chr11:96,816,987...96,826,474
Ensembl chr11:96,818,930...96,828,656

G

proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of PRRG3 mRNA

NCBI chr X:71,005,769...71,016,328
Ensembl chr X:71,006,230...71,016,328

G

peroxiredoxin like 2A

increases expression

tributyltin results in increased expression of PRXL2A mRNA

NCBI chr14:40,715,692...40,735,790
Ensembl chr14:40,715,697...40,735,745

G

proteasome (prosome, macropain) assembly chaperone 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of PSMG3 mRNA

NCBI chr 5:139,809,368...139,812,649
Ensembl chr 5:139,809,347...139,812,640

G

phosphatase and tensin homolog

increases expression

tributyltin results in increased expression of PTEN mRNA

NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560

G

prostaglandin reductase 1

increases expression

tributyltin results in increased expression of PTGR1 mRNA

NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119

G

prostaglandin-endoperoxide synthase 2

increases expression

tributyltin results in increased expression of PTGS2 mRNA
tributyltin results in increased expression of PTGS2 protein

PMID:19371601 PMID:23743147

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

protein tyrosine phosphatase, non-receptor type 11

increases expression

tributyltin results in increased expression of PTPN11 mRNA

NCBI chr 5:121,268,596...121,329,460
Ensembl chr 5:121,268,596...121,329,460

G

protein tyrosine phosphatase receptor type N

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of PTPRN mRNA

NCBI chr 1:75,223,679...75,241,437
Ensembl chr 1:75,223,671...75,241,146

G

protein tyrosine phosphatase receptor type T

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of PTPRT mRNA

NCBI chr 2:161,363,908...162,503,106
Ensembl chr 2:161,363,910...162,503,067

G

peroxisomal membrane protein 4

decreases expression

tributyltin results in decreased expression of PXMP4 mRNA

NCBI chr 2:154,427,678...154,445,592
Ensembl chr 2:154,427,678...154,445,628

G

PYD and CARD domain containing

increases expression

tributyltin results in increased expression of PYCARD mRNA

NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039

G

RAB24, member RAS oncogene family

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of RAB24 mRNA

NCBI chr13:55,467,036...55,469,807
Ensembl chr13:55,467,556...55,469,759

G

RAB25, member RAS oncogene family

increases expression

tributyltin results in increased expression of RAB25 mRNA

NCBI chr 3:88,449,335...88,455,586
Ensembl chr 3:88,449,336...88,455,607

G

RAB37, member RAS oncogene family

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of RAB37 mRNA

NCBI chr11:114,982,257...115,053,066
Ensembl chr11:114,982,257...115,053,062

G

RAB3B, member RAS oncogene family

increases expression

tributyltin results in increased expression of RAB3B mRNA

NCBI chr 4:108,736,267...108,800,521
Ensembl chr 4:108,736,260...108,800,521

G

RAD18 E3 ubiquitin protein ligase

increases expression

tributyltin results in increased expression of RAD18 mRNA

NCBI chr 6:112,596,812...112,673,650
Ensembl chr 6:112,596,811...112,673,647

G

v-raf-leukemia viral oncogene 1

multiple interactions

tributyltin affects the expression of and results in increased phosphorylation of RAF1 protein

NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596

G

retinoic acid receptor, beta

increases expression

tributyltin results in increased expression of RARB mRNA

NCBI chr14:5,387,365...6,038,924
Ensembl chr14:5,650,540...6,038,924

G

retinoic acid receptor, gamma

increases expression
multiple interactions

tributyltin results in increased expression of RARG mRNA
tributyltin results in increased activity of [RARG protein binds to RXRA protein]

PMID:21683754 PMID:30639747

NCBI chr15:102,143,373...102,165,891
Ensembl chr15:102,143,373...102,165,952

G

retinoic acid receptor responder (tazarotene induced) 2

increases expression

tributyltin results in increased expression of RARRES2 mRNA

NCBI chr 6:48,546,630...48,549,778
Ensembl chr 6:48,546,630...48,549,723

G

RAS protein activator like 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of RASAL2 mRNA

NCBI chr 1:156,962,759...157,240,170
Ensembl chr 1:156,962,752...157,240,165

G

RAS, dexamethasone-induced 1

increases expression
multiple interactions

tributyltin results in increased expression of RASD1 mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of RASD1 mRNA

NCBI chr11:59,854,007...59,855,770
Ensembl chr11:59,854,007...59,855,770

G

RAS guanyl releasing protein 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of RASGRP1 mRNA

NCBI chr 2:117,110,464...117,173,358
Ensembl chr 2:117,110,474...117,173,482

G

Ras association (RalGDS/AF-6) domain family member 5

increases expression

tributyltin results in increased expression of RASSF5 mRNA

NCBI chr 1:131,104,147...131,172,915
Ensembl chr 1:131,104,147...131,172,995

G

retinoblastoma binding protein 6, ubiquitin ligase

increases expression

tributyltin results in increased expression of RBBP6 mRNA

NCBI chr 7:122,568,980...122,601,780
Ensembl chr 7:122,564,909...122,601,780

G

RNA binding protein gene with multiple splicing

increases expression

tributyltin results in increased expression of RBPMS mRNA

NCBI chr 8:34,272,671...34,419,925
Ensembl chr 8:34,272,671...34,419,891

G

receptor accessory protein 6

increases expression

tributyltin results in increased expression of REEP6 mRNA

NCBI chr10:80,165,831...80,172,275
Ensembl chr10:80,165,787...80,172,275

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions
increases expression
increases phosphorylation

Phycocyanin inhibits the reaction [tributyltin results in increased expression of RELA protein]
tributyltin results in increased phosphorylation of RELA protein

PMID:23743147 PMID:26079211 PMID:30172001 PMID:36319700

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

resistin

increases expression

tributyltin results in increased expression of RETN mRNA

NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110

G

retinol saturase (all trans retinol 13,14 reductase)

increases expression

tributyltin results in increased expression of RETSAT mRNA

NCBI chr 6:72,575,585...72,584,471
Ensembl chr 6:72,575,458...72,585,408

G

refilin B

increases expression

tributyltin results in increased expression of RFLNB mRNA

NCBI chr11:75,910,020...75,918,608
Ensembl chr11:75,910,020...75,918,608

G

regulatory factor X 8

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of RFX8 mRNA

NCBI chr 1:39,704,459...39,760,149
Ensembl chr 1:39,704,461...39,760,157

G

regulator of G-protein signaling 3

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of RGS3 mRNA
tributyltin results in increased expression of RGS3 mRNA

NCBI chr 4:62,478,079...62,621,256
Ensembl chr 4:62,478,084...62,622,238

G

RIC3 acetylcholine receptor chaperone

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of RIC3 mRNA

NCBI chr 7:108,633,475...108,682,538
Ensembl chr 7:108,633,519...108,682,538

G

ribosomal modification protein rimK-like family member B

increases expression

tributyltin results in increased expression of RIMKLB mRNA

NCBI chr 6:122,424,255...122,464,021
Ensembl chr 6:122,424,255...122,475,720

G

RBPJ interacting and tubulin associated 1

decreases expression

tributyltin results in decreased expression of RITA1 mRNA

NCBI chr 5:120,747,123...120,750,654
Ensembl chr 5:120,732,370...120,750,654

G

relaxin 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of RLN1 mRNA

NCBI chr19:29,309,155...29,312,070
Ensembl chr19:29,308,570...29,312,070

G

ring finger protein 115

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of RNF115 mRNA

NCBI chr 3:96,634,869...96,698,471
Ensembl chr 3:96,634,980...96,698,954

G

ring finger protein 144A

decreases expression

tributyltin results in decreased expression of RNF144A mRNA

NCBI chr12:26,356,796...26,465,296
Ensembl chr12:26,350,963...26,465,253

G

ring finger protein 20

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of RNF20 mRNA

NCBI chr 4:49,632,005...49,656,887
Ensembl chr 4:49,632,006...49,656,887

G

ring finger protein 212

increases expression

tributyltin results in increased expression of RNF212 mRNA

NCBI chr 5:108,875,971...108,922,933
Ensembl chr 5:108,877,156...108,922,848

G

ring finger protein 39

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of RNF39 mRNA

NCBI chr17:37,253,943...37,258,878
Ensembl chr17:37,253,810...37,258,878

G

roundabout guidance receptor 2

increases expression

tributyltin results in increased expression of ROBO2 mRNA

NCBI chr16:73,688,725...75,244,331
Ensembl chr16:73,688,727...74,889,765

G

Rho-associated coiled-coil containing protein kinase 1

increases expression

tributyltin results in increased expression of ROCK1 mRNA

NCBI chr18:10,064,401...10,182,225
Ensembl chr18:10,064,401...10,182,045

G

Rho-associated coiled-coil containing protein kinase 2

increases expression

tributyltin results in increased expression of ROCK2 mRNA

NCBI chr12:16,944,808...17,038,275
Ensembl chr12:16,944,896...17,037,824

G

ribosomal protein S23, retrogene 1

increases expression

tributyltin results in increased expression of RPS23RG1 mRNA

NCBI chr 8:3,617,998...3,634,776
Ensembl chr 8:3,617,990...3,634,939

G

ribosomal protein S6

affects expression

tributyltin affects the expression of RPS6 protein

NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649

G

ribosomal protein S6 kinase polypeptide 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of RPS6KA3 mRNA

NCBI chr X:158,038,652...158,151,240
Ensembl chr X:157,993,303...158,151,240

G

RNA pseudouridylate synthase domain containing 2

increases expression

tributyltin results in increased expression of RPUSD2 mRNA

NCBI chr 2:118,865,271...118,872,679
Ensembl chr 2:118,865,271...118,870,250

G

ribonucleotide reductase M1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of RRM1 mRNA

NCBI chr 7:102,090,902...102,118,978
Ensembl chr 7:102,090,902...102,118,978

G

ribosomal RNA processing 12 homolog

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of RRP12 mRNA

NCBI chr19:41,847,922...41,884,592
Ensembl chr19:41,851,290...41,884,612

G

remodeling and spacing factor 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of RSF1 mRNA

NCBI chr 7:97,229,103...97,341,989
Ensembl chr 7:97,229,096...97,341,985

G

arginine/serine-rich coiled-coil 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of RSRC1 mRNA

NCBI chr 3:66,888,694...67,265,736
Ensembl chr 3:66,888,723...67,265,729

G

RNA transcription, translation and transport factor

increases expression

tributyltin results in increased expression of RTRAF mRNA

NCBI chr14:19,861,470...19,873,891
Ensembl chr14:19,861,419...19,873,892

G

runt related transcription factor 2

decreases expression

tributyltin results in decreased expression of RUNX2 mRNA

PMID:23322813 PMID:24513447 PMID:25777084 PMID:25932594

NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684

G

retinoid X receptor alpha

multiple interactions
increases activity
increases expression
decreases response to substance

[tributyltin binds to and results in increased activity of RXRA protein] which results in increased expression of CYP19A1 protein; RXRA protein affects the reaction [tributyltin results in increased expression of and results in increased activity of HSD11B2 protein]; RXRA protein affects the reaction [tributyltin results in increased expression of HSD11B2 mRNA]; RXRA protein affects the reaction [tributyltin results in increased expression of HSD11B2 protein]; tributyltin inhibits the reaction [Alitretinoin binds to RXRA protein]; tributyltin inhibits the reaction [triphenyltin hydroxide binds to RXRA protein]; tributyltin results in increased activity of [RARG protein binds to RXRA protein]
tributyltin results in increased activity of RXRA protein
tributyltin results in increased expression of RXRA mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of RXRA protein
tributyltin results in increased expression of RXRA protein
RXRA protein mutant form results in decreased susceptibility to tributyltin

PMID:15941851 PMID:27131391 PMID:29787037 PMID:30027469 PMID:30639747 More...

NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969

G

retinoid X receptor beta

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of RXRB protein
tributyltin results in increased expression of RXRB protein

NCBI chr17:34,250,786...34,257,377
Ensembl chr17:34,250,786...34,257,373

G

retinoid X receptor gamma

increases expression
multiple interactions

tributyltin results in increased expression of RXRG mRNA
tributyltin results in increased expression of RXRG protein
[bisphenol A co-treated with tributyltin] results in increased expression of RXRG protein

PMID:23428407 PMID:24848799 PMID:30027469 PMID:31129395

NCBI chr 1:167,425,902...167,467,191
Ensembl chr 1:167,425,953...167,467,192

G

S100 calcium binding protein A6 (calcyclin)

increases expression

tributyltin results in increased expression of S100A6 mRNA

NCBI chr 3:90,520,491...90,531,797
Ensembl chr 3:90,520,189...90,531,488

G

S100 calcium binding protein A8 (calgranulin A)

increases expression

tributyltin results in increased expression of S100A8 mRNA

NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342

G

serum amyloid A 1

decreases expression

tributyltin results in decreased expression of SAA1 mRNA

NCBI chr 7:46,389,921...46,392,404
Ensembl chr 7:46,389,921...46,392,404

G

serum amyloid A 2

affects expression

tributyltin affects the expression of SAA2 mRNA

NCBI chr 7:46,401,257...46,403,737
Ensembl chr 7:46,401,214...46,403,737

G

spalt like transcription factor 2

increases expression

tributyltin results in increased expression of SALL2 mRNA

NCBI chr14:52,548,634...52,566,127
Ensembl chr14:52,548,629...52,566,219

G

spalt like transcription factor 3

decreases expression

tributyltin results in decreased expression of SALL3 mRNA

NCBI chr18:81,010,204...81,030,236
Ensembl chr18:81,009,591...81,029,986

G

SAS-6 centriolar assembly protein

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of SASS6 mRNA

NCBI chr 3:116,388,577...116,424,816
Ensembl chr 3:116,388,631...116,424,653

G

S phase cyclin A-associated protein in the ER

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of SCAPER mRNA

NCBI chr 9:55,457,163...55,845,505
Ensembl chr 9:55,457,163...55,845,403

G

scavenger receptor class A, member 5

decreases expression

tributyltin results in decreased expression of SCARA5 mRNA

NCBI chr14:65,903,852...66,002,275
Ensembl chr14:65,903,852...66,002,275

G

scavenger receptor class B, member 1

decreases expression

tributyltin results in decreased expression of SCARB1 mRNA; tributyltin results in decreased expression of SCARB1 protein

NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158

G

stearoyl-Coenzyme A desaturase 1

increases expression

tributyltin results in increased expression of SCD1 mRNA

PMID:23428407 PMID:30027469

NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318

G

stearoyl-coenzyme A desaturase 3

increases expression

tributyltin results in increased expression of SCD3 mRNA

NCBI chr19:44,191,727...44,232,455
Ensembl chr19:44,191,708...44,232,455

G

sodium channel, voltage-gated, type V, alpha

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of SCN5A mRNA

NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082

G

sodium channel, voltage-gated, type VIII, alpha

decreases expression

tributyltin results in decreased expression of SCN8A mRNA

NCBI chr15:100,766,600...100,943,819
Ensembl chr15:100,767,739...100,943,819

G

sodium channel, voltage-gated, type IX, alpha

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of SCN9A mRNA

NCBI chr 2:66,310,424...66,465,456
Ensembl chr 2:66,310,424...66,465,306

G

sterol carrier protein 2, liver

increases expression

tributyltin results in increased expression of SCP2 mRNA

NCBI chr 4:107,901,027...108,002,168
Ensembl chr 4:107,901,036...108,002,195

G

syndecan binding protein (syntenin) 2

increases expression

tributyltin results in increased expression of SDCBP2 mRNA

NCBI chr 2:151,414,203...151,431,925
Ensembl chr 2:151,414,542...151,431,925

G

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of SDHB mRNA

NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504

G

SEC24 homolog B, COPII coat complex component

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of SEC24B mRNA

NCBI chr 3:129,776,408...129,855,248
Ensembl chr 3:129,776,408...129,855,202

G

selenium binding protein 2

decreases expression

tributyltin results in decreased expression of SELENBP2 mRNA

NCBI chr 3:94,600,880...94,611,713
Ensembl chr 3:94,600,863...94,611,720

G

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

increases expression

tributyltin results in increased expression of SEMA3B mRNA

NCBI chr 9:107,474,868...107,486,440
Ensembl chr 9:107,474,873...107,486,428

G

serine (or cysteine) peptidase inhibitor, clade B, member 1a

increases expression

tributyltin results in increased expression of SERPINB1A mRNA

NCBI chr13:33,026,075...33,037,189
Ensembl chr13:33,026,075...33,035,168

G

SERTA domain containing 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of SERTAD3 mRNA

NCBI chr 7:27,173,265...27,176,789
Ensembl chr 7:27,173,193...27,176,789

G

SET nuclear oncogene

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of SET protein

NCBI chr 2:29,952,074...29,962,589
Ensembl chr 2:29,947,390...29,962,589

G

stratifin

increases expression

tributyltin results in increased expression of SFN mRNA

NCBI chr 4:133,327,867...133,329,163
Ensembl chr 4:133,327,867...133,329,479

G

sphingosine-1-phosphate phosphatase 2

increases expression

tributyltin results in increased expression of SGPP2 mRNA

NCBI chr 1:78,286,186...78,396,926
Ensembl chr 1:78,286,982...78,396,926

G

SH2B adaptor protein 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of SH2B2 mRNA

NCBI chr 5:136,247,003...136,275,446
Ensembl chr 5:136,247,001...136,275,410

G

SH3 and multiple ankyrin repeat domains 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of SHANK2 mRNA

NCBI chr 7:143,531,819...143,979,780
Ensembl chr 7:143,555,665...143,978,231

G

sex hormone binding globulin

multiple interactions
decreases secretion

[bisphenol A co-treated with tributyltin] results in decreased secretion of SHBG protein
tributyltin results in decreased secretion of SHBG protein

NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731

G

shisa family member 7

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of SHISA7 mRNA

NCBI chr 7:4,828,551...4,847,788
Ensembl chr 7:4,828,551...4,847,695

G

sialic acid binding Ig-like lectin 1, sialoadhesin

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of SIGLEC1 mRNA

NCBI chr 2:130,911,140...130,928,697
Ensembl chr 2:130,911,140...130,928,685

G

sine oculis-related homeobox 6

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of SIX6 mRNA

NCBI chr12:72,986,656...72,991,673
Ensembl chr12:72,986,666...72,991,673

G

solute carrier family 12 (potassium/chloride transporters), member 8

increases expression

tributyltin results in increased expression of SLC12A8 mRNA

NCBI chr16:33,337,440...33,484,508
Ensembl chr16:33,337,698...33,484,505

G

solute carrier family 13 (sodium-dependent citrate transporter), member 5

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of SLC13A5 mRNA

NCBI chr11:72,132,816...72,158,092
Ensembl chr11:72,132,815...72,158,048

G

solute carrier family 16 (monocarboxylic acid transporters), member 3

increases expression

tributyltin results in increased expression of SLC16A3 mRNA; tributyltin results in increased expression of SLC16A3 protein

PMID:21683754 PMID:28993852

NCBI chr11:120,839,310...120,849,826
Ensembl chr11:120,839,306...120,851,694

G

solute carrier family 16 (monocarboxylic acid transporters), member 6

decreases expression

tributyltin results in decreased expression of SLC16A6 mRNA

NCBI chr11:109,341,681...109,366,428
Ensembl chr11:109,341,681...109,364,424

G

solute carrier family 18 (vesicular monoamine), member 2

multiple interactions

tributyltin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]

NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444

G

solute carrier family 1 (neutral amino acid transporter), member 5

increases expression

tributyltin results in increased expression of SLC1A5 mRNA

NCBI chr 7:16,515,259...16,532,199
Ensembl chr 7:16,515,265...16,532,199

G

solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of SLC1A6 mRNA

NCBI chr10:78,615,923...78,650,659
Ensembl chr10:78,616,330...78,650,599

G

solute carrier family 23 (nucleobase transporters), member 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of SLC23A3 mRNA

NCBI chr 1:75,102,185...75,112,113
Ensembl chr 1:75,102,185...75,110,534

G

solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20

increases expression

tributyltin results in increased expression of SLC25A20 mRNA

NCBI chr 9:108,539,335...108,561,841
Ensembl chr 9:108,539,287...108,561,840

G

solute carrier family 25, member 33

increases expression

tributyltin results in increased expression of SLC25A33 mRNA

NCBI chr 4:149,828,493...149,858,746
Ensembl chr 4:149,828,493...149,858,734

G

solute carrier family 26, member 5

increases expression

tributyltin results in increased expression of SLC26A5 mRNA

NCBI chr 5:22,013,999...22,070,602
Ensembl chr 5:22,015,653...22,070,602

G

solute carrier family 26, member 6

increases expression

tributyltin results in increased expression of SLC26A6 mRNA

NCBI chr 9:108,731,239...108,742,117
Ensembl chr 9:108,730,482...108,742,117

G

solute carrier family 27 (fatty acid transporter), member 1

increases expression

tributyltin results in increased expression of SLC27A1 mRNA

NCBI chr 8:72,021,372...72,039,951
Ensembl chr 8:72,021,526...72,039,946

G

solute carrier family 27 (fatty acid transporter), member 6

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of SLC27A6 mRNA; [bisphenol A co-treated with tributyltin] results in increased expression of SLC27A6 protein

NCBI chr18:58,689,312...58,745,941
Ensembl chr18:58,689,329...58,745,845

G

solute carrier family 28 (sodium-coupled nucleoside transporter), member 2

increases expression

tributyltin results in increased expression of SLC28A2 mRNA

NCBI chr 2:122,256,836...122,291,633
Ensembl chr 2:122,256,958...122,291,618

G

solute carrier family 2 (facilitated glucose transporter), member 2

increases expression

tributyltin results in increased expression of SLC2A2 mRNA

NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508

G

solute carrier family 2 (facilitated glucose transporter), member 3

decreases expression

tributyltin results in decreased expression of SLC2A3 mRNA

NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599

G

solute carrier family 2 (facilitated glucose transporter), member 4

decreases expression

tributyltin results in decreased expression of SLC2A4 protein

NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014

G

solute carrier family 2 (facilitated glucose transporter), member 5

increases expression

tributyltin results in increased expression of SLC2A5 mRNA

NCBI chr 4:150,203,801...150,228,625
Ensembl chr 4:150,203,740...150,228,626

G

solute carrier family 30 (zinc transporter), member 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of SLC30A4 mRNA

NCBI chr 2:122,523,153...122,544,583
Ensembl chr 2:122,523,153...122,544,583

G

solute carrier family 30 (zinc transporter), member 9

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of SLC30A9 mRNA
tributyltin results in increased expression of SLC30A9 mRNA

NCBI chr 5:67,464,298...67,513,485
Ensembl chr 5:67,464,298...67,515,786

G

solute carrier family 34 (sodium phosphate), member 2

decreases expression

tributyltin results in decreased expression of SLC34A2 mRNA

NCBI chr 5:53,206,695...53,229,006
Ensembl chr 5:53,195,423...53,229,006

G

solute carrier family 37 (glycerol-3-phosphate transporter), member 1

increases expression

tributyltin results in increased expression of SLC37A1 mRNA

NCBI chr17:31,495,722...31,569,683
Ensembl chr17:31,505,766...31,569,713

G

solute carrier family 37 (glycerol-3-phosphate transporter), member 2

increases expression

tributyltin results in increased expression of SLC37A2 mRNA

NCBI chr 9:37,140,445...37,166,709
Ensembl chr 9:37,138,881...37,167,034

G

solute carrier family 39 (metal ion transporter), member 5

increases expression

tributyltin results in increased expression of SLC39A5 mRNA

NCBI chr10:128,231,796...128,237,145
Ensembl chr10:128,231,800...128,237,098

G

solute carrier family 3, member 1

increases expression

tributyltin results in increased expression of SLC3A1 mRNA

NCBI chr17:85,335,775...85,371,669
Ensembl chr17:85,335,804...85,371,664

G

solute carrier family 46, member 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of SLC46A2 mRNA

NCBI chr 4:59,905,899...59,915,056
Ensembl chr 4:59,905,126...59,915,056

G

solute carrier family 4, sodium bicarbonate cotransporter, member 7

increases expression

tributyltin results in increased expression of SLC4A7 mRNA

NCBI chr14:7,669,819...7,766,808
Ensembl chr14:7,669,823...7,767,484

G

solute carrier family 5 (sodium/glucose cotransporter), member 1

increases expression

tributyltin results in increased expression of SLC5A1 mRNA

NCBI chr 5:33,261,563...33,320,043
Ensembl chr 5:33,261,563...33,320,214

G

solute carrier family 5 (sodium-dependent vitamin transporter), member 6

increases expression

tributyltin results in increased expression of SLC5A6 mRNA

NCBI chr 5:31,193,380...31,206,268
Ensembl chr 5:31,193,380...31,206,268

G

solute carrier family 6 (neurotransmitter transporter), member 15

decreases expression

tributyltin results in decreased expression of SLC6A15 mRNA

NCBI chr10:103,203,320...103,255,240
Ensembl chr10:103,203,644...103,255,238

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of SLC7A3 mRNA

NCBI chr X:100,122,752...100,134,058
Ensembl chr X:100,122,816...100,129,626

G

small integral membrane protein 13

decreases expression

tributyltin results in decreased expression of SMIM13 mRNA

NCBI chr13:41,403,320...41,430,053
Ensembl chr13:41,403,320...41,430,053

G

small integral membrane protein 24

increases expression

tributyltin results in increased expression of SMIM24 mRNA

NCBI chr10:81,228,898...81,230,913
Ensembl chr10:81,228,885...81,231,226

G

sphingomyelin phosphodiesterase, acid-like 3B

increases expression

tributyltin results in increased expression of SMPDL3B mRNA

NCBI chr 4:132,460,277...132,484,558
Ensembl chr 4:132,460,277...132,484,563

G

suppressor of cytokine signaling 3

decreases expression

tributyltin results in decreased expression of SOCS3 mRNA

NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873

G

sorbin and SH3 domain containing 1

increases expression

tributyltin results in increased expression of SORBS1 mRNA

NCBI chr19:40,280,484...40,502,399
Ensembl chr19:40,283,197...40,502,223

G

SRY (sex determining region Y)-box 5

decreases expression

tributyltin results in decreased expression of SOX5 mRNA

NCBI chr 6:143,774,151...144,728,008
Ensembl chr 6:143,774,151...144,727,703

G

SRY (sex determining region Y)-box 6

decreases expression

tributyltin results in decreased expression of SOX6 mRNA

NCBI chr 7:115,070,107...115,639,186
Ensembl chr 7:115,070,107...115,638,031

G

SRY (sex determining region Y)-box 9

multiple interactions
decreases expression

[tributyltin co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SOX9 mRNA
tributyltin results in decreased expression of SOX9 mRNA

PMID:22749964 PMID:24513447

NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586

G

Sp7 transcription factor 7

multiple interactions
decreases expression

tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SP7 mRNA]
tributyltin results in decreased expression of SP7 mRNA

PMID:25777084 PMID:25932594

NCBI chr15:102,265,038...102,275,498
Ensembl chr15:102,265,041...102,275,617

G

spastin

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of SPAST mRNA

NCBI chr17:74,643,805...74,698,110
Ensembl chr17:74,645,982...74,698,110

G

spermatogenesis associated 22

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of SPATA22 mRNA

NCBI chr11:73,217,416...73,237,447
Ensembl chr11:73,220,567...73,236,870

G

sphingosine kinase 1

decreases expression

tributyltin results in decreased expression of SPHK1 mRNA

NCBI chr11:116,421,662...116,427,502
Ensembl chr11:116,421,751...116,427,501

G

serine peptidase inhibitor, Kazal type 1

increases expression

tributyltin results in increased expression of SPINK1 mRNA

NCBI chr18:43,861,134...43,870,302
Ensembl chr18:43,861,147...43,870,622

G

serine protease inhibitor, Kunitz type 1

increases expression

tributyltin results in increased expression of SPINT1 mRNA

NCBI chr 2:119,067,841...119,079,995
Ensembl chr 2:119,067,843...119,080,008

G

sperm microtubule inner protein 9

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of SPMIP9 mRNA

NCBI chr 6:70,890,073...70,928,078
Ensembl chr 6:70,890,071...70,895,911

G

spondin 2, extracellular matrix protein

increases expression

tributyltin results in increased expression of SPON2 mRNA

NCBI chr 5:33,370,862...33,375,596
Ensembl chr 5:33,355,528...33,375,799

G

spectrin alpha, non-erythrocytic 1

increases cleavage

tributyltin results in increased cleavage of SPTAN1 protein

NCBI chr 2:29,855,572...29,921,463
Ensembl chr 2:29,855,572...29,921,463

G

serine palmitoyltransferase, small subunit A

increases expression

tributyltin results in increased expression of SPTSSA mRNA

NCBI chr12:54,692,159...54,703,357
Ensembl chr12:54,692,177...54,703,358

G

sequestosome 1

increases expression

tributyltin results in increased expression of SQSTM1 protein

NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654

G

Rous sarcoma oncogene

affects methylation

tributyltin affects the methylation of SRC 5' UTR; tributyltin affects the methylation of SRC exon; tributyltin affects the methylation of SRC promoter

NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782

G

steroid 5 alpha-reductase 1

decreases activity
multiple interactions

tributyltin results in decreased activity of SRD5A1 protein
[Finasteride co-treated with tributyltin co-treated with Testosterone] results in increased expression of SRD5A1 mRNA; [tributyltin co-treated with Testosterone] results in increased expression of SRD5A1 mRNA

PMID:12231121 PMID:23523586

NCBI chr13:69,721,568...69,759,611
Ensembl chr13:69,721,568...69,759,561

G

steroid 5 alpha-reductase 2

decreases activity
increases expression
multiple interactions

tributyltin results in decreased activity of SRD5A2 protein
tributyltin results in increased expression of SRD5A2 mRNA
Finasteride promotes the reaction [tributyltin inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]]; tributyltin inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]; tributyltin promotes the reaction [Finasteride inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]]

PMID:12231121 PMID:21683754 PMID:23523586

NCBI chr17:74,321,886...74,354,855
Ensembl chr17:74,323,950...74,354,911

G

sterol regulatory element binding transcription factor 1

multiple interactions
increases expression

[tributyltin co-treated with LHB protein] results in increased expression of SREBF1 mRNA; tributyltin promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]
tributyltin results in increased expression of SREBF1 mRNA

PMID:23322813 PMID:25932594 PMID:28011154 PMID:38630605

NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407

G

sushi-repeat-containing protein, X-linked 2

increases expression

tributyltin results in increased expression of SRPX2 mRNA

NCBI chr X:132,809,155...132,833,195
Ensembl chr X:132,809,175...132,833,195

G

SS nuclear autoantigen 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of SSNA1 mRNA

NCBI chr 2:25,161,051...25,162,430
Ensembl chr 2:25,161,051...25,162,450

G

suppression of tumorigenicity 14 (colon carcinoma)

increases expression

tributyltin results in increased expression of ST14 mRNA

NCBI chr 9:30,999,886...31,043,138
Ensembl chr 9:31,000,698...31,043,149

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ST3GAL3 mRNA

NCBI chr 4:117,789,349...117,992,169
Ensembl chr 4:117,789,351...117,992,111

G

suppression of tumorigenicity 7

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ST7 mRNA

NCBI chr 6:17,693,579...17,943,022
Ensembl chr 6:17,692,932...17,943,024

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6

decreases expression

tributyltin results in decreased expression of ST8SIA6 mRNA

NCBI chr 2:13,659,745...13,798,659
Ensembl chr 2:13,655,832...13,798,875

G

steroidogenic acute regulatory protein

decreases expression
increases expression

tributyltin results in decreased expression of STAR mRNA; tributyltin results in decreased expression of STAR protein
tributyltin results in increased expression of STAR mRNA

PMID:28707438 PMID:29549738 PMID:31006824 PMID:35430282

NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010

G

STEAP family member 4

decreases expression

tributyltin results in decreased expression of STEAP4 mRNA

NCBI chr 5:8,010,472...8,032,213
Ensembl chr 5:8,010,457...8,032,213

G

serine threonine kinase 31

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of STK31 mRNA

NCBI chr 6:49,372,441...49,446,440
Ensembl chr 6:49,372,538...49,446,435

G

storkhead box 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of STOX1 mRNA

NCBI chr10:62,494,822...62,561,907
Ensembl chr10:62,494,822...62,561,907

G

stereocilin

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of STRC mRNA

NCBI chr 2:121,193,729...121,211,851
Ensembl chr 2:121,194,209...121,217,649

G

succinate-CoA ligase, GDP-forming, alpha subunit

increases expression

tributyltin results in increased expression of SUCLG1 mRNA

NCBI chr 6:73,225,488...73,253,890
Ensembl chr 6:73,225,365...73,253,894

G

sulfotransferase family, cytosolic, 1C, member 2

increases expression

tributyltin results in increased expression of SULT1C2 mRNA

NCBI chr17:54,136,665...54,152,986
Ensembl chr17:54,136,665...54,153,367

G

sulfotransferase family, cytosolic, 2B, member 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of SULT2B1 mRNA

NCBI chr 7:45,379,405...45,409,096
Ensembl chr 7:45,379,407...45,434,093

G

synaptic vesicle glycoprotein 2b

increases expression

tributyltin results in increased expression of SV2B mRNA

NCBI chr 7:74,764,642...74,959,143
Ensembl chr 7:74,764,642...74,959,010

G

syntabulin (syntaxin-interacting)

decreases expression

tributyltin results in decreased expression of SYBU mRNA

NCBI chr15:44,535,252...44,651,466
Ensembl chr15:44,535,252...44,651,459

G

spleen tyrosine kinase

increases expression

tributyltin results in increased expression of SYK mRNA

NCBI chr13:52,736,670...52,802,828
Ensembl chr13:52,737,209...52,802,828

G

synaptopodin 2

increases expression

tributyltin results in increased expression of SYNPO2 mRNA

NCBI chr 3:122,870,168...123,029,817
Ensembl chr 3:122,870,168...123,029,798

G

synaptotagmin XII

decreases expression

tributyltin results in decreased expression of SYT12 mRNA

NCBI chr19:4,495,936...4,527,171
Ensembl chr19:4,495,936...4,527,475

G

synaptotagmin IV

increases expression

tributyltin results in increased expression of SYT4 mRNA

NCBI chr18:31,570,861...31,580,468
Ensembl chr18:31,570,861...31,580,459

G

synaptotagmin-like 4

decreases expression
multiple interactions

tributyltin results in decreased expression of SYTL4 mRNA
[bisphenol A co-treated with tributyltin] results in decreased expression of SYTL4 mRNA

NCBI chr X:132,837,134...132,882,569
Ensembl chr X:132,837,134...132,882,561

G

transforming, acidic coiled-coil containing protein 2

decreases expression

tributyltin results in decreased expression of TACC2 mRNA

NCBI chr 7:130,154,735...130,369,435
Ensembl chr 7:130,179,168...130,366,515

G

TATA-box binding protein associated factor, RNA polymerase I, A

increases expression
multiple interactions

tributyltin results in increased expression of TAF1A mRNA
[bisphenol A co-treated with tributyltin] results in increased expression of TAF1A mRNA

NCBI chr 1:183,170,251...183,195,776
Ensembl chr 1:183,170,325...183,191,020

G

transport and golgi organization 6

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of TANGO6 mRNA

NCBI chr 8:107,409,697...107,581,175
Ensembl chr 8:107,409,700...107,578,071

G

taste receptor, type 2, member 135

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of TAS2R135 mRNA

NCBI chr 6:42,382,463...42,383,428
Ensembl chr 6:42,382,368...42,383,460

G

transcription activation suppressor family member 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of TASOR2 mRNA

NCBI chr13:3,615,905...3,661,108
Ensembl chr13:3,616,035...3,661,108

G

T-box 20

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of TBX20 mRNA

NCBI chr 9:24,632,108...24,685,580
Ensembl chr 9:24,629,434...24,685,599

G

transcription factor 23

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of TCF23 mRNA

NCBI chr 5:31,125,946...31,145,406
Ensembl chr 5:31,126,006...31,134,362

G

tectonin beta-propeller repeat containing 1

increases expression

tributyltin results in increased expression of TECPR1 mRNA

NCBI chr 5:144,131,260...144,160,433
Ensembl chr 5:144,131,260...144,160,433

G

thyrotroph embryonic factor

increases expression

tributyltin results in increased expression of TEF mRNA

NCBI chr15:81,686,874...81,711,064
Ensembl chr15:81,686,622...81,711,064

G

telomerase reverse transcriptase

increases expression

tributyltin results in increased expression of TERT mRNA

NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962

G

testis expressed metallothionein like

decreases expression

tributyltin results in decreased expression of TESMIN protein

PMID:24055800 PMID:28707438

NCBI chr19:3,438,857...3,457,823
Ensembl chr19:3,438,857...3,457,823

G

testis expressed 38

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of TEX38 mRNA

NCBI chr 4:115,633,178...115,639,925
Ensembl chr 4:115,637,031...115,638,215

G

transferrin receptor

increases expression

tributyltin results in increased expression of TFRC mRNA

NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612

G

transforming growth factor alpha

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of TGFA mRNA

NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701

G

transforming growth factor, beta 1

increases expression

tributyltin results in increased expression of TGFB1 mRNA

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

transglutaminase 2, C polypeptide

multiple interactions
increases expression

diazepinylbenzoic acid inhibits the reaction [tributyltin results in increased expression of TGM2 mRNA]

PMID:21622945 PMID:25932594

NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356

G

thyroid hormone receptor alpha

multiple interactions

tributyltin binds to and results in increased activity of THRA protein

NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832

G

thyroid hormone receptor beta

increases expression
multiple interactions

tributyltin results in increased expression of THRB mRNA
tributyltin binds to and results in increased activity of THRB protein

PMID:30027469 PMID:33049310

NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435

G

thyroid hormone responsive

increases expression

tributyltin results in increased expression of THRSP mRNA

NCBI chr 7:97,062,140...97,066,757
Ensembl chr 7:97,062,145...97,066,937

G

thymus cell antigen 1, theta

decreases expression

tributyltin results in decreased expression of THY1 mRNA

NCBI chr 9:43,954,681...43,959,876
Ensembl chr 9:43,954,681...43,959,876

G

tight junction protein 1

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [tributyltin results in decreased expression of TJP1 protein]

NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529

G

TLC domain containing 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of TLCD4 mRNA

NCBI chr 3:120,995,657...121,076,756
Ensembl chr 3:120,995,410...121,076,747

G

TLE family member 7

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of TLE7 mRNA

NCBI chr 8:110,827,964...110,838,646
Ensembl chr 8:110,827,839...110,838,593

G

transmembrane 4 L six family member 20

increases expression

tributyltin results in increased expression of TM4SF20 mRNA

NCBI chr 1:82,734,368...82,746,182
Ensembl chr 1:82,734,370...82,746,182

G

transmembrane channel-like gene family 4

increases expression

tributyltin results in increased expression of TMC4 mRNA

NCBI chr 7:3,668,790...3,680,522
Ensembl chr 7:3,668,789...3,680,552

G

transmembrane protein 106A

increases expression

tributyltin results in increased expression of TMEM106A mRNA

NCBI chr11:101,473,068...101,482,612
Ensembl chr11:101,473,068...101,482,614

G

transmembrane protein 128

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of TMEM128 mRNA

NCBI chr 5:38,417,529...38,426,978
Ensembl chr 5:38,417,529...38,426,978

G

transmembrane protein 171

decreases expression

tributyltin results in decreased expression of TMEM171 mRNA

NCBI chr13:98,822,744...98,832,142
Ensembl chr13:98,822,743...98,831,342

G

transmembrane protein 213

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of TMEM213 mRNA

NCBI chr 6:38,086,288...38,092,741
Ensembl chr 6:38,086,190...38,092,744

G

transmembrane protein 45b

increases expression

tributyltin results in increased expression of TMEM45B mRNA

NCBI chr 9:31,336,445...31,375,534
Ensembl chr 9:31,337,492...31,375,758

G

transmembrane protein 71

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of TMEM71 mRNA

NCBI chr15:66,398,061...66,433,085
Ensembl chr15:66,398,061...66,432,952

G

transmembrane protein 91

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of TMEM91 mRNA

NCBI chr 7:25,368,564...25,379,011
Ensembl chr 7:25,368,564...25,374,591

G

tropomodulin 1

increases expression

tributyltin results in increased expression of TMOD1 mRNA

NCBI chr 4:46,038,940...46,116,032
Ensembl chr 4:46,038,935...46,116,032

G

transmembrane protease, serine 4

increases expression

tributyltin results in increased expression of TMPRSS4 mRNA

NCBI chr 9:45,084,024...45,115,417
Ensembl chr 9:45,084,024...45,115,390

G

thioredoxin-related transmembrane protein 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of TMX3 mRNA

NCBI chr18:90,528,336...90,561,391
Ensembl chr18:90,528,278...90,561,391

G

tumor necrosis factor

multiple interactions
increases expression
affects expression

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [tributyltin results in increased expression of and results in increased secretion of TNF protein]; batimastat inhibits the reaction [tributyltin results in increased secretion of TNF protein]; tributyltin affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; tributyltin results in increased expression of and results in increased secretion of TNF protein
tributyltin results in increased expression of TNF protein
tributyltin results in increased expression of TNF mRNA
tributyltin affects the expression of TNF mRNA

PMID:17092623 PMID:29532501 PMID:30172001 PMID:36319700

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

multiple interactions

tributyltin promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased secretion of TNFRSF11B protein]
[bisphenol A co-treated with tributyltin] results in increased expression of TNFRSF11B mRNA

PMID:31016361 PMID:31129395

NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880

G

tumor necrosis factor receptor superfamily, member 19

increases expression

tributyltin results in increased expression of TNFRSF19 mRNA

NCBI chr14:61,201,283...61,284,304
Ensembl chr14:61,201,324...61,283,939

G

tumor necrosis factor receptor superfamily, member 9

decreases expression

tributyltin results in decreased expression of TNFRSF9 mRNA

NCBI chr 4:151,004,612...151,030,561
Ensembl chr 4:150,999,019...151,030,559

G

tumor necrosis factor (ligand) superfamily, member 11

multiple interactions

Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]

NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483

G

TOG array regulator of axonemal microtubules 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of TOGARAM1 mRNA

NCBI chr12:65,012,350...65,069,347
Ensembl chr12:65,012,578...65,069,347

G

torsin family 3, member A

decreases expression

tributyltin results in decreased expression of TOR3A mRNA

NCBI chr 1:156,481,187...156,501,909
Ensembl chr 1:156,481,187...156,501,926

G

TOX high mobility group box family member 4

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of TOX4 mRNA

NCBI chr14:52,516,603...52,532,966
Ensembl chr14:52,516,603...52,533,858

G

protein-tyrosine sulfotransferase 1

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of TPST1 mRNA
tributyltin results in increased expression of TPST1 mRNA

NCBI chr 5:130,102,167...130,164,575
Ensembl chr 5:130,102,167...130,164,570

G

tetratricopeptide repeat and ankyrin repeat containing 1

decreases expression

tributyltin results in decreased expression of TRANK1 mRNA

NCBI chr 9:111,140,351...111,224,843
Ensembl chr 9:111,140,807...111,224,843

G

trehalase (brush-border membrane glycoprotein)

increases expression

tributyltin results in increased expression of TREH mRNA

NCBI chr 9:44,584,530...44,597,602
Ensembl chr 9:44,584,530...44,597,602

G

transferrin

increases expression

tributyltin results in increased expression of TF mRNA

NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643

G

tribbles pseudokinase 3

increases expression

tributyltin results in increased expression of TRIB3 mRNA

NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952

G

tripartite motif-containing 47

increases expression

tributyltin results in increased expression of TRIM47 mRNA

NCBI chr11:115,996,576...116,001,061
Ensembl chr11:115,996,578...116,018,036

G

tripartite motif-containing 71

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of TRIM71 mRNA

NCBI chr 9:114,340,336...114,393,437
Ensembl chr 9:114,336,201...114,393,437

G

transformation related protein 53

increases expression
decreases expression
multiple interactions

tributyltin results in increased expression of TP53 protein
tributyltin results in decreased expression of TP53 protein
tributyltin results in increased expression of TRP53 protein
2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [tributyltin results in increased expression of TP53 protein]

PMID:25743928 PMID:26961604 PMID:33720505 PMID:36319700

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

transformation related protein 53 inducible nuclear protein 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of TP53INP2 mRNA

NCBI chr 2:155,223,742...155,231,767
Ensembl chr 2:155,222,979...155,231,770

G

transient receptor potential cation channel, subfamily M, member 4

increases expression

tributyltin results in increased expression of TRPM4 mRNA

NCBI chr 7:44,952,579...44,983,495
Ensembl chr 7:44,952,056...44,983,204

G

transient receptor potential cation channel, subfamily V, member 1

decreases expression

tributyltin results in decreased expression of TRPV1 mRNA

NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068

G

TSC22 domain family, member 3

decreases expression

tributyltin results in decreased expression of TSC22D3 mRNA

NCBI chr X:139,440,277...139,501,257
Ensembl chr X:139,440,277...139,501,408

G

tetraspanin 15

increases expression

tributyltin results in increased expression of TSPAN15 mRNA

NCBI chr10:62,021,175...62,067,055
Ensembl chr10:62,021,175...62,067,030

G

tetraspanin 3

increases expression

tributyltin results in increased expression of TSPAN3 mRNA

NCBI chr 9:56,043,168...56,068,354
Ensembl chr 9:56,039,009...56,072,761

G

tetraspanin 8

increases expression

tributyltin results in increased expression of TSPAN8 mRNA

NCBI chr10:115,652,722...115,685,798
Ensembl chr10:115,652,737...115,685,798

G

translocator protein

increases expression
affects expression

tributyltin results in increased expression of TSPO mRNA
tributyltin affects the expression of TSPO protein

PMID:21683754 PMID:28707438

NCBI chr15:83,447,774...83,458,404
Ensembl chr15:83,447,793...83,458,404

G

tetratricopeptide repeat domain 21A

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of TTC21A mRNA

NCBI chr 9:119,766,656...119,798,496
Ensembl chr 9:119,766,672...119,796,859

G

tubulin tyrosine ligase

decreases expression
multiple interactions

tributyltin results in decreased expression of TTL mRNA
[bisphenol A co-treated with tributyltin] results in decreased expression of TTL mRNA

NCBI chr 2:128,907,867...128,938,203
Ensembl chr 2:128,907,862...128,938,203

G

tubulin, beta 1 class VI

decreases expression

tributyltin results in decreased expression of TUBB1 mRNA

NCBI chr 2:174,292,388...174,300,173
Ensembl chr 2:174,292,488...174,299,675

G

tubulin, beta 2A class IIA

decreases expression

tributyltin results in decreased expression of TUBB2A mRNA

NCBI chr13:34,258,261...34,261,991
Ensembl chr13:34,258,257...34,261,990

G

tubulin, beta 3 class III

increases degradation
multiple interactions

tributyltin results in increased degradation of TUBB3 protein
CAST protein inhibits the reaction [tributyltin results in increased degradation of TUBB3 protein]

NCBI chr 8:124,138,292...124,148,754
Ensembl chr 8:124,138,163...124,148,754

G

tubulin, beta 6 class V

decreases expression

tributyltin results in decreased expression of TUBB6 mRNA

NCBI chr18:67,523,801...67,535,819
Ensembl chr18:67,523,787...67,535,819

G

tubulin, gamma 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of TUBG1 mRNA

NCBI chr11:101,010,725...101,017,249
Ensembl chr11:101,010,764...101,017,245

G

tubulin, gamma complex component 3

decreases expression

tributyltin results in decreased expression of TUBGCP3 mRNA

NCBI chr 8:12,664,277...12,722,141
Ensembl chr 8:12,664,277...12,722,248

G

twist basic helix-loop-helix transcription factor 1

multiple interactions
decreases expression

Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of TWIST1 mRNA]

NCBI chr12:34,007,670...34,009,830
Ensembl chr12:34,007,670...34,009,828

G

thioredoxin interacting protein

increases expression

tributyltin results in increased expression of TXNIP mRNA

NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199

G

tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of TYW3 mRNA

NCBI chr 3:154,282,157...154,302,750
Ensembl chr 3:154,282,068...154,302,741

G

uveal autoantigen with coiled-coil domains and ankyrin repeats

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of UACA mRNA

NCBI chr 9:60,700,488...60,787,713
Ensembl chr 9:60,701,824...60,787,652

G

ubiquitin protein ligase E3 component n-recognin 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of UBR1 mRNA

NCBI chr 2:120,690,753...120,801,246
Ensembl chr 2:120,690,750...120,801,196

G

uncoupling protein 1 (mitochondrial, proton carrier)

increases expression

tributyltin results in increased expression of UCP1 mRNA

NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081

G

uncoupling protein 2 (mitochondrial, proton carrier)

increases expression

tributyltin results in increased expression of UCP2 mRNA

NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227

G

UDP glucuronosyltransferase 1 family, polypeptide A7C

increases expression

tributyltin results in increased expression of UGT1A7C mRNA

NCBI chr 1:88,022,723...88,147,724
Ensembl chr 1:88,022,784...88,147,724

G

unc-119 lipid binding chaperone B

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of UNC119B mRNA

NCBI chr 5:115,260,625...115,273,034
Ensembl chr 5:115,260,609...115,273,034

G

unc-5 netrin receptor D

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of UNC5D mRNA

NCBI chr 8:29,136,745...29,709,698
Ensembl chr 8:29,136,745...29,709,664

G

uroplakin 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of UPK2 mRNA

NCBI chr 9:44,364,012...44,366,064
Ensembl chr 9:44,364,012...44,366,273

G

uridine phosphorylase 1

increases expression

tributyltin results in increased expression of UPP1 mRNA

NCBI chr11:9,068,008...9,086,170
Ensembl chr11:9,068,103...9,086,170

G

uridine phosphorylase 2

increases expression

tributyltin results in increased expression of UPP2 mRNA

NCBI chr 2:58,456,329...58,685,858
Ensembl chr 2:58,457,310...58,682,983

G

ubiquitin specific peptidase 2

increases expression

tributyltin results in increased expression of USP2 mRNA

NCBI chr 9:43,978,318...44,006,924
Ensembl chr 9:43,978,318...44,006,924

G

ubiquitin specific peptidase 43

increases expression

tributyltin results in increased expression of USP43 mRNA

NCBI chr11:67,745,349...67,812,979
Ensembl chr11:67,745,349...67,812,979

G

vav 3 oncogene

increases expression

tributyltin results in increased expression of VAV3 mRNA

NCBI chr 3:109,247,757...109,593,010
Ensembl chr 3:109,247,969...109,593,014

G

vitamin D (1,25-dihydroxyvitamin D3) receptor

decreases expression

tributyltin results in decreased expression of VDR mRNA

NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511

G

villin 1

increases expression

tributyltin results in increased expression of VIL1 mRNA

NCBI chr 1:74,448,543...74,474,719
Ensembl chr 1:74,448,535...74,474,718

G

vimentin

multiple interactions
decreases expression

Tretinoin promotes the reaction [tributyltin results in decreased expression of VIM mRNA]; Tretinoin promotes the reaction [tributyltin results in decreased expression of VIM protein]
tributyltin results in decreased expression of VIM mRNA; tributyltin results in decreased expression of VIM protein

PMID:30806631 PMID:31634547

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

G

V-set pre-B cell surrogate light chain 1A

increases expression

tributyltin results in increased expression of VPREB1 mRNA

NCBI chr16:16,686,265...16,687,119
Ensembl chr16:16,686,267...16,688,707

G

visual system homeobox 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of VSX1 mRNA

NCBI chr 2:150,522,622...150,531,057
Ensembl chr 2:150,522,622...150,531,280

G

WD repeat domain 3

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of WDR3 mRNA

NCBI chr 3:100,045,496...100,069,723
Ensembl chr 3:100,045,496...100,069,723

G

WD repeat domain 91

increases expression

tributyltin results in increased expression of WDR91 mRNA

NCBI chr 6:34,857,361...34,887,766
Ensembl chr 6:34,857,361...34,887,811

G

WEE 1 homolog 1 (S. pombe)

increases expression

tributyltin results in increased expression of WEE1 mRNA

NCBI chr 7:109,721,266...109,742,506
Ensembl chr 7:109,721,253...109,742,493

G

wingless-type MMTV integration site family, member 5A

decreases expression

tributyltin results in decreased expression of WNT5A mRNA

NCBI chr14:28,224,962...28,249,405
Ensembl chr14:28,226,707...28,249,405

G

Werner helicase interacting protein 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of WRNIP1 mRNA

NCBI chr13:32,986,013...33,006,593
Ensembl chr13:32,986,021...33,006,592

G

X-box binding protein 1

increases splicing

tributyltin results in increased splicing of XBP1 mRNA

NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893

G

xeroderma pigmentosum, complementation group A

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of XPA mRNA

NCBI chr 4:46,175,222...46,196,317
Ensembl chr 4:46,155,347...46,196,311

G

yippee like 2

decreases expression

tributyltin results in decreased expression of YPEL2 mRNA

NCBI chr11:86,827,251...86,884,629
Ensembl chr11:86,827,251...86,884,533

G

zinc finger and BTB domain containing 16

decreases expression

tributyltin results in decreased expression of ZBTB16 mRNA

NCBI chr 9:48,563,097...48,747,525
Ensembl chr 9:48,565,597...48,747,522

G

zinc finger and BTB domain containing 39

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ZBTB39 mRNA

NCBI chr10:127,575,399...127,583,218
Ensembl chr10:127,575,407...127,583,218

G

zinc finger and BTB domain containing 7B

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ZBTB7B mRNA

NCBI chr 3:89,284,953...89,300,976
Ensembl chr 3:89,284,951...89,302,083

G

zinc finger and BTB domain containing 7C

decreases expression

tributyltin results in decreased expression of ZBTB7C mRNA

NCBI chr18:75,953,249...76,281,635
Ensembl chr18:75,953,249...76,281,635

G

zinc finger, DHHC domain containing 2

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ZDHHC2 mRNA

NCBI chr 8:40,876,526...40,946,178
Ensembl chr 8:40,876,856...40,963,309

G

zinc finger protein 24

decreases expression

tributyltin results in decreased expression of ZFP24 mRNA

NCBI chr18:24,142,774...24,155,294
Ensembl chr18:24,142,759...24,153,867

G

zinc finger protein 281

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ZFP281 mRNA

NCBI chr 1:136,552,639...136,558,129
Ensembl chr 1:136,552,639...136,557,791

G

zinc finger protein 300

multiple interactions
increases expression

[bisphenol A co-treated with tributyltin] results in increased expression of ZFP300 mRNA
tributyltin results in increased expression of ZFP300 mRNA

NCBI chr X:20,944,447...20,955,934
Ensembl chr X:20,945,413...20,955,766

G

zinc finger protein 36

increases expression

tributyltin results in increased expression of ZFP36 mRNA

NCBI chr 7:28,076,208...28,078,680
Ensembl chr 7:28,076,209...28,079,678

G

zinc finger protein 423

increases expression

tributyltin results in increased expression of ZFP423 mRNA

NCBI chr 8:88,388,438...88,688,665
Ensembl chr 8:88,388,438...88,686,223

G

zinc finger protein 74

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ZFP74 mRNA

NCBI chr 7:29,632,086...29,653,579
Ensembl chr 7:29,630,240...29,653,514

G

zinc finger protein 800

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ZFP800 mRNA

NCBI chr 6:28,210,543...28,398,010
Ensembl chr 6:28,239,926...28,398,004

G

zinc finger with KRAB and SCAN domains 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in increased expression of ZKSCAN1 mRNA

NCBI chr 5:138,083,312...138,106,084
Ensembl chr 5:138,083,346...138,106,084

G

zinc finger with KRAB and SCAN domains 7

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ZKSCAN7 mRNA

NCBI chr 9:122,715,883...122,727,684
Ensembl chr 9:122,714,750...122,727,683

G

zinc finger, matrin type 1

multiple interactions

[bisphenol A co-treated with tributyltin] results in decreased expression of ZMAT1 mRNA

NCBI chr X:133,872,121...133,909,958
Ensembl chr X:133,872,121...133,909,958

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22298
chemical entity	22279
atom	22292
metal atom	19384
tin atom	1239
tin molecular entity	1239
organotin compound	1230
tributylstannane	1059
1-(dibutylstannyl)butan-2-ol	0
Path 2
Term	Annotations
CHEBI ontology	22298
subatomic particle	22274
composite particle	22292
hadron	22292
baryon	22292
nucleon	22274
atomic nucleus	22292
atom	22292
main group element atom	22153
main group molecular entity	22153
p-block molecular entity	22153
carbon group molecular entity	21974
organic molecular entity	21896
organometallic compound	6924
organotin compound	1230
tributylstannane	1059
1-(dibutylstannyl)butan-2-ol	0

paths to the root