Map2k3 (mitogen-activated protein kinase kinase 3) - Rat Genome Database

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Gene: Map2k3 (mitogen-activated protein kinase kinase 3) Mus musculus
Analyze
Symbol: Map2k3
Name: mitogen-activated protein kinase kinase 3
RGD ID: 1315343
MGI Page MGI
Description: Enables MAP kinase kinase activity and protein kinase binding activity. Acts upstream of or within several processes, including MAPK cascade; cardiac muscle contraction; and positive regulation of MAPK cascade. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in cervical cancer and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW212142; dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAPK/ERK kinase 3; MAPKK 3; MEK 3; MEK3; mitogen activated protein kinase kinase 3; MKK3; MKK3b; mMKK3b; Prkm; Prkmk3; protein kinase, mitogen-activated, kinase 3
RGD Orthologs
Human
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm12792  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,822,880 - 60,843,637 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,822,859 - 60,843,637 (+)EnsemblGRCm39 Ensembl
GRCm381160,932,054 - 60,952,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,932,033 - 60,952,811 (+)EnsemblGRCm38mm10GRCm38
MGSCv371160,745,559 - 60,766,305 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,748,252 - 60,768,998 (+)NCBIMGSCv36mm8
Celera1165,171,267 - 65,191,964 (+)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1137.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
9-cis,11-trans-octadecadienoic acid  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
cisplatin  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corn oil  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dinophysistoxin 1  (ISO)
diquat  (EXP)
disulfiram  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
etoposide  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glyphosate  (ISO)
hydralazine  (ISO)
indometacin  (ISO)
inulin  (EXP)
ivermectin  (ISO)
josamycin  (ISO)
L-ascorbic acid  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
malathion  (ISO)
manganese(II) chloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nimesulide  (ISO)
Nonylphenol  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
pirinixic acid  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
senecionine  (EXP)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

References

References - curated
# Reference Title Reference Citation
1. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
2. MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival. Demuth T, etal., Mol Cancer Ther. 2007 Apr;6(4):1212-22. Epub 2007 Apr 3.
3. Activation of ASK1, downstream MAPKK and MAPK isoforms during cardiac ischaemia. Harding SJ, etal., Biochim Biophys Acta. 2010 Sep;1802(9):733-40. doi: 10.1016/j.bbadis.2010.06.005. Epub 2010 Jun 13.
4. Thioredoxin inhibits NMDA-induced neurotoxicity in the rat retina. Inomata Y, etal., J Neurochem. 2006 Jul;98(2):372-85.
5. p38 MAPK and MAPK kinase 3/6 mRNA and activities are increased in early diabetic glomeruli. Kang SW, etal., Kidney Int. 2001 Aug;60(2):543-52.
6. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
7. p38 kinase is crucial for osteopontin-induced furin expression that supports cervical cancer progression. Kumar V, etal., Cancer Res. 2010 Dec 15;70(24):10381-91. doi: 10.1158/0008-5472.CAN-10-1470. Epub 2010 Oct 27.
8. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Liao P, etal., Proc Natl Acad Sci U S A 2001 Oct 9;98(21):12283-8. Epub 2001 Oct 02.
9. MAPK kinase 3 is a tumor suppressor with reduced copy number in breast cancer. Macneil AJ, etal., Cancer Res. 2013 Nov 14.
10. Activation of TGF-beta1-TAK1-p38 MAPK pathway in spared cardiomyocytes is involved in left ventricular remodeling after myocardial infarction in rats. Matsumoto-Ida M, etal., Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H709-15. Epub 2005 Sep 23.
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. MKK3, an upstream activator of p38, contributes to formalin phase 2 and late allodynia in mice. Sorkin LS, etal., Neuroscience. 2009 Aug 18;162(2):462-71. doi: 10.1016/j.neuroscience.2009.05.008. Epub 2009 May 8.
20. Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer. Wang HY, etal., Cancer Lett. 2003 Mar 10;191(2):229-37.
Additional References at PubMed
PMID:8889548   PMID:8900184   PMID:10097111   PMID:10202148   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11447117   PMID:12151339   PMID:12374793   PMID:12477932  
PMID:12520002   PMID:12690100   PMID:12893778   PMID:12904583   PMID:14610273   PMID:14633627   PMID:14634666   PMID:14657222   PMID:14681479   PMID:15143069   PMID:15489334   PMID:15644321  
PMID:15761153   PMID:15767678   PMID:15778378   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16199873   PMID:16237070   PMID:16357362   PMID:16365149   PMID:16567640   PMID:17030606  
PMID:17167049   PMID:17214902   PMID:17399693   PMID:17438131   PMID:17588539   PMID:17686961   PMID:17723219   PMID:18270588   PMID:18283273   PMID:18287559   PMID:18722365   PMID:18757346  
PMID:18799693   PMID:18948261   PMID:19066844   PMID:19224920   PMID:19265160   PMID:19342682   PMID:19525957   PMID:19561096   PMID:19564926   PMID:19713213   PMID:20004242   PMID:20023695  
PMID:20937847   PMID:21124890   PMID:21206905   PMID:21267068   PMID:21368234   PMID:21610252   PMID:21677750   PMID:21841136   PMID:21873635   PMID:22351764   PMID:22447969   PMID:23202732  
PMID:23275604   PMID:23492809   PMID:23729445   PMID:24319055   PMID:24400116   PMID:24453276   PMID:24457600   PMID:24480516   PMID:24487387   PMID:24596247   PMID:25135476   PMID:25406311  
PMID:25697779   PMID:26119780   PMID:26149640   PMID:26739490   PMID:26996129   PMID:27009039   PMID:27012769   PMID:27717867   PMID:28249877   PMID:31545406   PMID:32325033   PMID:32548640  
PMID:35080104   PMID:35592906   PMID:35971771  


Genomics

Comparative Map Data
Map2k3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,822,880 - 60,843,637 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,822,859 - 60,843,637 (+)EnsemblGRCm39 Ensembl
GRCm381160,932,054 - 60,952,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,932,033 - 60,952,811 (+)EnsemblGRCm38mm10GRCm38
MGSCv371160,745,559 - 60,766,305 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,748,252 - 60,768,998 (+)NCBIMGSCv36mm8
Celera1165,171,267 - 65,191,964 (+)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1137.95NCBI
MAP2K3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381721,284,711 - 21,315,240 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1721,284,672 - 21,315,232 (+)EnsemblGRCh38hg38GRCh38
GRCh371721,188,023 - 21,218,552 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361721,128,561 - 21,159,145 (+)NCBINCBI36Build 36hg18NCBI36
Build 341721,141,910 - 21,158,870NCBI
Cytogenetic Map17p11.2NCBI
HuRef1720,389,899 - 20,420,519 (+)NCBIHuRef
CHM1_11721,197,569 - 21,228,147 (+)NCBICHM1_1
T2T-CHM13v2.01721,233,580 - 21,264,159 (+)NCBIT2T-CHM13v2.0
Map2k3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,107,639 - 46,128,986 (+)NCBIGRCr8
mRatBN7.21045,608,145 - 45,629,492 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,607,163 - 45,629,492 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,310,306 - 50,331,733 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01049,800,693 - 49,822,120 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,304,279 - 45,325,706 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,089,455 - 45,110,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,182,433 - 47,203,753 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,089,464 - 45,110,787 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01044,847,090 - 44,868,491 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,075,270 - 47,096,617NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1044,862,946 - 44,884,272 (+)NCBICelera
Cytogenetic Map10q22NCBI
Map2k3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555771,237,287 - 1,248,541 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555771,225,033 - 1,249,510 (+)NCBIChiLan1.0ChiLan1.0
MAP2K3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1542,732,751 - 42,762,420 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl542,700,836 - 42,761,736 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha542,870,421 - 42,900,078 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0542,839,802 - 42,869,464 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl542,839,790 - 42,869,343 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1542,806,533 - 42,836,183 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0542,753,555 - 42,783,186 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0542,946,459 - 42,976,119 (+)NCBIUU_Cfam_GSD_1.0
Map2k3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560262,480,582 - 62,504,527 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936741362,387 - 386,678 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936741362,682 - 386,633 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,396,369 - 61,417,321 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,396,337 - 61,417,333 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAP2K3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11619,396,377 - 19,427,617 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1619,396,452 - 19,427,652 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660591,327,045 - 1,358,833 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248495,006,513 - 5,035,747 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248495,007,185 - 5,034,488 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map2k3
714 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1477
Count of miRNA genes:604
Interacting mature miRNAs:714
Transcripts:ENSMUST00000019076, ENSMUST00000126043, ENSMUST00000130269, ENSMUST00000137609, ENSMUST00000137739, ENSMUST00000145828
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5406567063319522Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115406567067078411Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115408094165103841Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115925661769482699Mouse

Markers in Region
Map2k3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B2UniSTS
cM Map11 UniSTS
RH126082  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381160,949,445 - 60,949,668UniSTSGRCm38
MGSCv371160,762,947 - 60,763,170UniSTSGRCm37
Celera1165,188,677 - 65,188,900UniSTS
Cytogenetic Map11B2UniSTS
Whitehead/MRC_RH11801.4UniSTS
MAP2K3_360  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381160,951,910 - 60,952,695UniSTSGRCm38
MGSCv371160,765,412 - 60,766,197UniSTSGRCm37
Celera1165,191,070 - 65,191,855UniSTS
Cytogenetic Map11B2UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_157293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK008141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK176968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL603830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X93150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000019076   ⟹   ENSMUSP00000019076
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1160,822,859 - 60,843,637 (+)Ensembl
GRCm38.p6 Ensembl1160,932,033 - 60,952,811 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126043
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1160,832,706 - 60,837,597 (+)Ensembl
GRCm38.p6 Ensembl1160,941,880 - 60,946,771 (+)Ensembl
RefSeq Acc Id: ENSMUST00000130269   ⟹   ENSMUSP00000114430
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1160,822,892 - 60,843,620 (+)Ensembl
GRCm38.p6 Ensembl1160,932,066 - 60,952,794 (+)Ensembl
RefSeq Acc Id: ENSMUST00000137609
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1160,841,488 - 60,842,647 (+)Ensembl
GRCm38.p6 Ensembl1160,950,662 - 60,951,821 (+)Ensembl
RefSeq Acc Id: ENSMUST00000137739
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1160,822,880 - 60,832,942 (+)Ensembl
GRCm38.p6 Ensembl1160,932,054 - 60,942,116 (+)Ensembl
RefSeq Acc Id: ENSMUST00000145828
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1160,822,880 - 60,838,417 (+)Ensembl
GRCm38.p6 Ensembl1160,932,054 - 60,947,591 (+)Ensembl
RefSeq Acc Id: NM_008928   ⟹   NP_032954
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391160,822,880 - 60,843,637 (+)NCBI
GRCm381160,932,054 - 60,952,811 (+)NCBI
MGSCv371160,745,559 - 60,766,305 (+)RGD
Celera1165,171,267 - 65,191,964 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_157293
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391160,822,880 - 60,843,637 (+)NCBI
GRCm381160,932,054 - 60,952,811 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032954   ⟸   NM_008928
- UniProtKB: P97293 (UniProtKB/Swiss-Prot),   Q91VX1 (UniProtKB/Swiss-Prot),   O09110 (UniProtKB/Swiss-Prot),   Q5SWN9 (UniProtKB/TrEMBL),   Q3TLX7 (UniProtKB/TrEMBL),   Q3TX82 (UniProtKB/TrEMBL),   Q3UDI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000114430   ⟸   ENSMUST00000130269
RefSeq Acc Id: ENSMUSP00000019076   ⟸   ENSMUST00000019076
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09110-F1-model_v2 AlphaFold O09110 1-347 view protein structure

Promoters
RGD ID:6821242
Promoter ID:MM_KWN:7753
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000012915,   OTTMUST00000014413,   OTTMUST00000014414,   OTTMUST00000014415,   OTTMUST00000014417
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361160,744,581 - 60,746,007 (+)MPROMDB
RGD ID:8674912
Promoter ID:EPDNEW_M15487
Type:initiation region
Name:Map2k3_1
Description:Mus musculus mitogen-activated protein kinase kinase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381160,932,057 - 60,932,117EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346868 AgrOrtholog
Ensembl Genes ENSMUSG00000018932 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000019076 ENTREZGENE
  ENSMUST00000019076.10 UniProtKB/Swiss-Prot
  ENSMUST00000130269 ENTREZGENE
  ENSMUST00000130269.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26397 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1346868 ENTREZGENE
NCBI Gene 26397 ENTREZGENE
PANTHER DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Map2k3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J1Q6_MOUSE UniProtKB/TrEMBL
  MP2K3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  P97293 ENTREZGENE
  Q3TJG7_MOUSE UniProtKB/TrEMBL
  Q3TLX7 ENTREZGENE, UniProtKB/TrEMBL
  Q3TX82 ENTREZGENE, UniProtKB/TrEMBL
  Q3UDI2 ENTREZGENE, UniProtKB/TrEMBL
  Q5SWN9 ENTREZGENE, UniProtKB/TrEMBL
  Q91VX1 ENTREZGENE
UniProt Secondary P97293 UniProtKB/Swiss-Prot
  Q91VX1 UniProtKB/Swiss-Prot