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Gene: Esr2 (estrogen receptor 2 (beta)) Mus musculus
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Description: Exhibits DNA binding activity. Involved in several processes, including hormone-mediated signaling pathway; nervous system development; and reproductive structure development. Localizes to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); autoimmune hypersensitivity disease (multiple); hypospadias; and neurodegenerative disease (multiple). Is expressed in several structures, including central nervous system; genitourinary system; heart mesentery; limb segment; and mammary gland primordium. Orthologous to human ESR2 (estrogen receptor 2); PARTICIPATES IN bisphenol A response pathway; estrogen signaling pathway; tamoxifen pharmacodynamics pathway; INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; (S)-naringenin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ER beta; ER-beta; ER[b]; ERbeta; Estrb; estrogen receptor beta; nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta
Homo sapiens (human) : ESR2 (estrogen receptor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Esr2 (estrogen receptor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Esr2 (estrogen receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ESR2 (estrogen receptor 2)
Canis lupus familiaris (dog) : ESR2 (estrogen receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Esr2 (estrogen receptor 2)
Sus scrofa (pig) : ESR2 (estrogen receptor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381276,120,419 - 76,177,259 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371277,221,406 - 77,278,246 (-)NCBIGRCm37mm9NCBIm37
MGSCv361277,039,259 - 77,096,099 (-)NCBImm8
Celera1277,215,189 - 77,271,340 (-)NCBICelera
Cytogenetic Map12 C3NCBI
cM Map1233.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Esr2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10552
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.