Esr2 (estrogen receptor 2 (beta)) - Rat Genome Database

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Gene: Esr2 (estrogen receptor 2 (beta)) Mus musculus
Symbol: Esr2
Name: estrogen receptor 2 (beta)
RGD ID: 10552
Description: Enables DNA binding activity. Acts upstream of or within several processes, including hormone-mediated signaling pathway; nervous system development; and reproductive structure development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart mesentery; limb segment; and mammary gland primordium. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); hypospadias; neurodegenerative disease (multiple); and ovarian dysgenesis 8. Orthologous to human ESR2 (estrogen receptor 2); PARTICIPATES IN bisphenol A response pathway; estrogen signaling pathway; tamoxifen pharmacodynamics pathway; INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; (S)-naringenin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ER beta; ER-beta; ER[b]; ERbe; ERbeta; Est; Estrb; estrogen receptor beta; nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391276,167,193 - 76,224,033 (-)NCBIGRCm39mm39
GRCm39 Ensembl1276,167,193 - 76,224,033 (-)Ensembl
GRCm381276,120,419 - 76,177,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,120,419 - 76,177,259 (-)EnsemblGRCm38mm10GRCm38
MGSCv371277,221,406 - 77,278,246 (-)NCBIGRCm37mm9NCBIm37
MGSCv361277,039,259 - 77,096,099 (-)NCBImm8
Celera1277,215,189 - 77,271,340 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
adenoma  (ISO)
alopecia  (ISO)
Alzheimer's disease  (IEP,ISO)
Animal Mammary Neoplasms  (ISO)
anxiety disorder  (ISO)
aortic valve stenosis  (ISO)
asthma  (ISO)
atherosclerosis  (IDA)
atrial fibrillation  (ISO)
Blast Crisis  (IMP)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
Cocaine-Related Disorders  (ISO)
Cognitive Dysfunction  (ISO)
colitis  (IEP,ISO)
colon cancer  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (IMP)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
cystitis  (ISO)
Deafness  (IMP)
Endometrial Neoplasms  (ISO)
endometriosis  (IDA,ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (IDA,IMP)
Experimental Melanoma  (IMP)
Female Infertility  (ISO)
glomerulosclerosis  (IEP)
Graves' disease  (ISO)
Hand Osteoarthritis  (ISO)
Hashimoto Disease  (ISO)
Hearing Loss  (IMP)
Hemorrhagic Shock  (ISO)
Hot Flashes  (ISO)
Hyperalgesia  (IMP,ISO)
hypertension  (IMP,ISO)
hypospadias  (ISO)
in situ carcinoma  (ISO)
inflammatory bowel disease  (ISO)
interstitial cystitis  (IMP)
Knee Osteoarthritis  (ISO)
Left Ventricular Hypertrophy  (IDA)
Lithiasis  (ISO)
Lung Injury  (ISO)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
mental depression  (ISO)
myasthenia gravis  (ISO)
myeloid leukemia  (IMP)
Myocardial Reperfusion Injury  (IMP)
obesity  (ISO)
osteoarthritis  (ISO)
osteoporosis  (IEP,ISO)
Osteoporotic Fractures  (ISO)
ovarian dysgenesis 8  (ISO)
Parkinson's disease  (ISO)
peritonitis  (ISO)
Pituitary Neoplasms  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-eclampsia  (ISO)
primary open angle glaucoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (IDA)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
retinal degeneration  (IMP)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (IMP)
Stroke  (ISO)
systemic lupus erythematosus  (IDA,ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urination Disorders  (ISO)
Varicose Ulcer  (ISO)
Vulvar Lichen Sclerosus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(3-phenoxyphenyl)methanol  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-bromopropane  (EXP)
1-Hydroxypyrene  (ISO)
1-naphthol  (ISO)
10H-phenothiazine  (ISO)
16-Ketoestrone  (ISO)
17alpha-estradiol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Bisphenol F  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,4,5-trichlorophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dichlorophenol  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,6-diisopropylnaphthalene  (ISO)
2,6-dimethylnaphthalene  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-hydroxyestrone  (ISO)
2-tert-butylhydroquinone  (ISO)
2-tert-Butylphenol  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (EXP,ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (ISO)
3,3'-Dimethylbenzidine  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one  (ISO)
3-phenoxybenzoic acid  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-Androstenediol  (ISO)
4-chloro-3,5-dimethylphenol  (ISO)
4-ethylphenol  (EXP,ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-Hydroxybenzophenone  (ISO)
4-nitrophenol  (ISO)
4-nitrotoluene  (ISO)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (EXP,ISO)
4-Propylphenol  (EXP)
4-tert-butylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5alpha-androstane-3alpha,17beta-diol  (ISO)
5alpha-androstane-3beta,17beta-diol  (ISO)
6-oxocampestanol  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
9,9-bis(4-hydroxyphenyl)fluorene  (ISO)
9-cis-retinoic acid  (ISO)
9-phenanthrol  (ISO)
acetochlor  (ISO)
acetophenone  (ISO)
acrylamide  (ISO)
adenosine  (EXP,ISO)
afimoxifene  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-phytoene  (ISO)
all-trans-phytofluene  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (ISO)
androgen antagonist  (ISO)
androst-4-ene-3,17-dione  (ISO)
androst-5-ene-3beta,17beta-diol  (EXP,ISO)
androstane-3,17-diol  (ISO)
anilines  (ISO)
apigenin  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azadirachtin A  (EXP,ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzophenone  (ISO)
benzyl benzoate  (ISO)
Benzyl parahydroxybenzoate  (ISO)
Benzyl salicylate  (ISO)
beta-carotene  (ISO)
beta-hexachlorocyclohexane  (EXP,ISO)
beta-naphthoflavone  (ISO)
beta-tocopherol  (ISO)
beta-Zearalanol  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bifenthrin  (ISO)
biochanin A  (EXP,ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-ol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
brassinolide  (ISO)
Bromofos  (ISO)
Bromophos-ethyl  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butylbenzene  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
butyric acid  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbaryl  (ISO)
carbendazim  (ISO)
carbon nanotube  (EXP)
carfilzomib  (ISO)
cedrol  (ISO)
chlordecone  (EXP,ISO)
chlorogenic acid  (ISO)
chloropropylate  (ISO)
chlorpyrifos  (EXP)
chlorpyrifos-methyl  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
citral  (ISO)
clomiphene  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumaphos  (ISO)
coumestrol  (EXP,ISO)
Cuprizon  (ISO)
cyanazine  (ISO)
Cyanofenphos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (ISO)
cypermethrin  (EXP,ISO)
cyproterone acetate  (ISO)
D-aspartic acid  (EXP)
D-glucose  (ISO)
daidzein  (EXP,ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
dehydroepiandrosterone  (ISO)
delta-hexachlorocyclohexane  (ISO)
delta-tocopherol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
dibutyl phthalate  (EXP,ISO)
Dichlofenthion  (ISO)
dicofol  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (EXP,ISO)
dienestrol  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
diheptyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (EXP)
dimethoate  (EXP)
diniconazole  (ISO)
dioscin  (EXP,ISO)
diosgenin  (EXP)
dioxygen  (ISO)
dipentyl phthalate  (ISO)
diphenylmethanol  (ISO)
dipropyl phthalate  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
emetine  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
endrin  (ISO)
enilconazole  (EXP,ISO)
enzacamene  (ISO)
equilin  (ISO)
equol  (ISO)
estradiol  (ISO)
estriol  (EXP,ISO)
estrone  (EXP,ISO)
estrone 3-sulfate  (ISO)
ethanol  (ISO)
ethion  (ISO)
Ethyl cinnamate  (ISO)
ethyl myristate  (ISO)
ethylparaben  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fenamiphos  (ISO)
fenarimol  (EXP,ISO)
fenbuconazole  (ISO)
fenhexamid  (ISO)
fenitrothion  (ISO)
fenpyroximate  (ISO)
fenthion  (ISO)
fentin chloride  (ISO)
fenvalerate  (ISO)
finasteride  (ISO)
fingolimod hydrochloride  (ISO)
fipronil  (ISO)
flavone  (ISO)
fludioxonil  (ISO)
fluoranthene  (ISO)
fluoxastrobin  (ISO)
flutamide  (EXP,ISO)
formononetin  (ISO)
fulvestrant  (EXP,ISO)
galaxolide  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (ISO)
geranial  (ISO)
geraniol  (ISO)
glucose  (ISO)
glycitein  (ISO)
glycitin  (ISO)
glyphosate  (ISO)
heptachlor  (ISO)
Heptachlor epoxide  (ISO)
herbicide  (ISO)
hexestrol  (ISO)
hydrogencarbonate  (EXP)
hydroquinone O-beta-D-glucopyranoside  (EXP,ISO)
ICI-164384  (ISO)
indinavir  (EXP)
indoles  (EXP)
ipriflavone  (ISO)
iprodione  (ISO)
irilone  (ISO)
Isobutylparaben  (ISO)
isoflavones  (ISO)
Isopropylparaben  (ISO)
isorhamnetin  (ISO)
isotretinoin  (ISO)
kaempferol  (EXP,ISO)
kresoxim-methyl  (ISO)
L-ascorbic acid  (ISO)
lamivudine  (EXP)
lasofoxifene  (ISO)
leptophos  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP)
liquiritigenin  (ISO)
luteolin  (ISO)
lycopene  (ISO)
M1  (ISO)
mancozeb  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mestranol  (ISO)
metconazole  (ISO)
metformin  (ISO)
methimazole  (EXP)
methiocarb  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (EXP,ISO)
methyl laurate  (ISO)
Methyl palmitate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
metolachlor  (ISO)
mifepristone  (ISO)
Mitotane  (ISO)
MK 571  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (EXP,ISO)
monoethyl phthalate  (EXP)
Moxestrol  (ISO)
mycophenolic acid  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butylbenzenesulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
n-propyl gallate  (ISO)
Nafoxidine  (ISO)
nandrolone  (ISO)
Nandrolone decanoate  (ISO)
napropamide  (ISO)
naringin  (ISO)
nebivolol  (ISO)
Nonylphenol  (ISO)
norethisterone  (ISO)
Norethynodrel  (ISO)
notoginsenoside R1  (ISO)
nuarimol  (ISO)
O-Desmethylangolensin  (ISO)
octocrylene  (ISO)
ormeloxifene  (ISO)
oryzalin  (ISO)
Osajin  (ISO)
Oxadiazon  (ISO)
oxybenzone  (ISO)
p-tert-Amylphenol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (ISO)
parathion-methyl  (ISO)
pendimethalin  (ISO)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenothrin  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalic acid  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
Pomiferin  (ISO)
potassium dichromate  (ISO)
prallethrin  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propamocarb  (ISO)
propargite  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
propyzamide  (ISO)
prothiofos  (ISO)
pterostilbene  (EXP)
puerarin  (ISO)
pyrazoles  (ISO)
pyrene  (ISO)
pyridaben  (ISO)
quercetin  (ISO)
quinalphos  (ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Rhapontigenin  (ISO)
rifapentine  (ISO)
Rosavin  (ISO)
rotenone  (ISO)
royal jelly  (ISO)
rubitecan  (ISO)
rutin  (ISO)
salicylates  (ISO)
saquinavir  (EXP)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silibinin  (ISO)
sodium arsenite  (EXP,ISO)
sodium hypochlorite  (ISO)
sophoraflavanone B  (ISO)
staurosporine  (ISO)
streptozocin  (EXP)
tamoxifen  (EXP,ISO)
teniposide  (ISO)
testosterone  (EXP,ISO)
Testosterone propionate  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (ISO)
tetrachlorvinphos  (ISO)
tetradifon  (ISO)
tetralin  (ISO)
tetramethrin  (ISO)
tibolone  (ISO)
tolclofos-methyl  (ISO)
topotecan  (ISO)
toremifene  (EXP,ISO)
toxaphene  (ISO)
trans-piceid  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trifloxystrobin  (ISO)
trifluralin  (ISO)
trifluridine  (ISO)
trilostane  (EXP)
triphenyl phosphate  (ISO)
Triphenylethylene  (ISO)
triptonide  (EXP)
triticonazole  (ISO)
undecan-2-one  (ISO)
Urolithin A  (ISO)
valinomycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP,ISO)
vinyl carbamate  (EXP)
zearalenone  (EXP,ISO)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amygdala development  (ISO)
behavioral fear response  (ISO)
brain development  (IMP)
cellular response to estradiol stimulus  (ISO)
cellular response to magnetism  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cerebellum development  (ISO)
epithelial cell maturation involved in prostate gland development  (IMP)
estrous cycle  (ISO)
female gonad development  (ISO)
hormone-mediated apoptotic signaling pathway  (IMP)
hypothalamus development  (ISO)
intracellular estrogen receptor signaling pathway  (IMP,ISO)
intracellular steroid hormone receptor signaling pathway  (IBA,ISO)
learning or memory  (ISO)
male gonad development  (ISO)
negative regulation of androgen receptor signaling pathway  (IMP)
negative regulation of behavior  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell population proliferation  (IGI)
negative regulation of epithelial cell proliferation  (IMP,ISO)
negative regulation of feeding behavior  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron migration  (IMP)
ovarian follicle development  (IMP,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
prostate gland development  (ISO)
prostate gland epithelium morphogenesis  (IMP)
regulation of cell population proliferation  (IMP)
regulation of neuron apoptotic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (IEA)
response to activity  (ISO)
response to bisphenol A  (ISO)
response to dexamethasone  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to genistein  (ISO)
response to hormone  (ISO)
response to human chorionic gonadotropin  (ISO)
response to insecticide  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to salt  (ISO)
response to testosterone  (ISO)
response to water deprivation  (ISO)
response to xenobiotic stimulus  (ISO)
Sertoli cell development  (ISO)
Sertoli cell proliferation  (ISO)
uterus development  (IGI)
vagina development  (IGI)
vasodilation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal auditory brainstem response  (IAGP)
abnormal B cell number  (IAGP)
abnormal behavior  (IAGP)
abnormal bone marrow cell number  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone ossification  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal cochlear IHC afferent innervation pattern  (IAGP)
abnormal colon goblet cell morphology  (IAGP)
abnormal cumulus oophorus morphology  (IAGP)
abnormal enterocyte apoptosis  (IAGP)
abnormal enterocyte morphology  (IAGP)
abnormal enterocyte physiology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal estrous cycle  (IAGP)
abnormal excitatory postsynaptic potential  (IAGP)
abnormal germ cell morphology  (IAGP)
abnormal hair cycle catagen phase  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal intercalated disk morphology  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal leukopoiesis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal mammary gland epithelium morphology  (IAGP)
abnormal mammary gland growth during lactation  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal mature ovarian follicle morphology  (IAGP)
abnormal muscle contractility  (IAGP)
abnormal muscle electrophysiology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal neocortex morphology  (IAGP)
abnormal nociception after inflammation  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal ovulation  (IAGP)
abnormal primary ovarian follicle morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal response of heart to induced stress  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal rete testis morphology  (IAGP)
abnormal secondary ovarian follicle morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal Sertoli cell morphology  (IAGP)
abnormal sexual interaction  (IAGP)
abnormal somatosensory cortex morphology  (IAGP)
abnormal spatial learning  (IAGP)
abnormal stomach morphology  (IAGP)
abnormal substantia nigra morphology  (IAGP)
abnormal superovulation  (IAGP)
abnormal surfactant physiology  (IAGP)
abnormal synaptic plasticity  (IAGP)
abnormal urinary bladder morphology  (IAGP)
abnormal urinary bladder physiology  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
abnormal uterus weight  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vertebrae morphology  (IAGP)
absent corpus luteum  (IAGP)
absent mature ovarian follicles  (IAGP)
accelerated hair follicle regression  (IAGP)
anemia  (IAGP)
anovulation  (IAGP)
ascites  (IAGP)
asthenozoospermia  (IAGP)
astrocytosis  (IAGP)
cachexia  (IAGP)
cardiac hypertrophy  (IAGP)
colitis  (IAGP)
decreased aggression towards males  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased brain size  (IAGP)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased chemical nociceptive threshold  (IAGP)
decreased circulating follicle stimulating hormone level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating osteocalcin level  (IAGP)
decreased compact bone area  (IAGP)
decreased corpora lutea number  (IAGP)
decreased dopamine level  (IAGP)
decreased exploration in new environment  (IAGP)
decreased insulin secretion  (IAGP)
decreased litter size  (IAGP)
decreased male germ cell number  (IAGP)
decreased neuron number  (IAGP)
decreased ovulation rate  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased serotonin level  (IAGP)
decreased spleen weight  (IAGP)
decreased uterus weight  (IAGP)
decreased vertical activity  (IAGP)
decreased volumetric bone mineral density  (IAGP)
delayed wound healing  (IAGP)
dilated heart ventricle  (IAGP)
dilated seminiferous tubules  (IAGP)
enlarged heart  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged myocardial fiber  (IAGP)
enlarged pancreatic islets  (IAGP)
enlarged spleen  (IAGP)
failure of ejaculation  (IAGP)
female infertility  (IAGP)
hypoactivity  (IAGP)
hyporesponsive to tactile stimuli  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired cued conditioning behavior  (IAGP)
impaired granulosa cell differentiation  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased aggression towards females  (IAGP)
increased aggression towards males  (IAGP)
increased anxiety-related response  (IAGP)
increased body length  (IAGP)
increased body weight  (IAGP)
increased bone marrow cell number  (IAGP)
increased bone strength  (IAGP)
increased chronic myelocytic leukemia incidence  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating insulin-like growth factor I level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased colon adenoma incidence  (IAGP)
increased compact bone area  (IAGP)
increased double-positive T cell number  (IAGP)
increased erythrocyte cell number  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased granulocyte number  (IAGP)
increased heart weight  (IAGP)
increased insulin sensitivity  (IAGP)
increased keratinocyte apoptosis  (IAGP)
increased leukocyte cell number  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased osteoblast cell number  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pre-B cell number  (IAGP)
increased pro-B cell number  (IAGP)
increased retroperitoneal fat pad weight  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased testis tumor incidence  (IAGP)
increased thigmotaxis  (IAGP)
increased total body fat amount  (IAGP)
increased urine glycosaminoglycan level  (IAGP)
increased vasoconstriction  (IAGP)
increased vasodilation  (IAGP)
insulin resistance  (IAGP)
long femur  (IAGP)
male infertility  (IAGP)
mammary gland alveolar hyperplasia  (IAGP)
myelofibrosis  (IAGP)
neuron degeneration  (IAGP)
no abnormal phenotype detected  (IEA)
obese  (IAGP)
oligozoospermia  (IAGP)
ovary cyst  (IAGP)
premature death  (IAGP)
prostate gland epithelial hyperplasia  (IAGP)
reduced female fertility  (IAGP)
reduced long term potentiation  (IAGP)
short femur  (IAGP)
short ulna  (IAGP)
small vagina  (IAGP)
spleen hyperplasia  (IAGP)
spleen hypoplasia  (IAGP)
thin epidermis  (IAGP)
thin uterus  (IAGP)
thymus hypoplasia  (IAGP)
urinary bladder inflammation  (IAGP)
uterus hypoplasia  (IAGP)
vagina hypoplasia  (IAGP)

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PMID:8977441   PMID:9027582   PMID:9058381   PMID:9192892   PMID:9236206   PMID:9256346   PMID:9278514   PMID:9280064   PMID:9348186   PMID:9607809   PMID:9671811   PMID:9685228  
PMID:9697695   PMID:9768697   PMID:9772337   PMID:9927291   PMID:10230404   PMID:10330493   PMID:10342848   PMID:10342850   PMID:10349636   PMID:10368776   PMID:10406480   PMID:10426580  
PMID:10510330   PMID:10536018   PMID:10552042   PMID:10575212   PMID:10600740   PMID:10624800   PMID:10642567   PMID:10681503   PMID:10732323   PMID:10733896   PMID:10788465   PMID:10805804  
PMID:10823946   PMID:10867819   PMID:10919284   PMID:10927619   PMID:10927637   PMID:10976058   PMID:10995228   PMID:11014235   PMID:11042159   PMID:11074057   PMID:11076861   PMID:11095962  
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