Txnip (thioredoxin interacting protein) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Txnip (thioredoxin interacting protein) Mus musculus
Analyze
Symbol: Txnip
Name: thioredoxin interacting protein
RGD ID: 732141
MGI Page MGI
Description: Enables enzyme inhibitor activity. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; platelet-derived growth factor receptor signaling pathway; and protein import into nucleus. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Reye syndrome and hepatocellular carcinoma. Orthologous to human TXNIP (thioredoxin interacting protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1200008J08Rik; AA682105; Hyp; hyperlipidemia 1; Hyplip1; mVDU; Tbp-2; THI; THIF; thioredoxin binding protein-2; thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; VDU; VDUP1; vitamin D3 up-regulated protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,465,273 - 96,469,173 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,465,273 - 96,469,199 (+)EnsemblGRCm39 Ensembl
GRCm38396,557,957 - 96,561,857 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,557,957 - 96,561,883 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,361,880 - 96,365,780 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,643,362 - 96,647,271 (+)NCBIMGSCv36mm8
Celera397,964,967 - 97,968,875 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (EXP)
(-)-demecolcine  (ISO)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
7,8-diacetoxy-4-methylcoumarin  (ISO)
aconitine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
Aflatoxin G1  (ISO)
Aflatoxin G2  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
allose  (ISO)
alpha-D-galactose  (ISO)
AM-251  (ISO)
amphotericin B  (ISO)
anthocyanin  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (ISO)
aucubin  (EXP,ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
baicalin  (EXP)
barium sulfate  (ISO)
beauvericin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
celastrol  (ISO)
ceric oxide  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (EXP)
Cinobufagin  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
Clofop  (ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (ISO)
curcumin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
deguelin  (ISO)
dehydroepiandrosterone  (EXP,ISO)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (EXP)
diclofenac  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
difenoconazole  (ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
enniatin  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
estriol  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
fentin chloride  (ISO)
fipronil  (ISO)
fluoranthene  (EXP)
flusilazole  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
furan  (ISO)
galactose  (ISO)
Ganoderic acid A  (EXP)
gedunin  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexadecanoic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroxychloroquine  (ISO)
indometacin  (ISO)
inulin  (EXP)
ionomycin  (EXP)
irinotecan  (ISO)
iron atom  (EXP)
iron dextran  (EXP)
iron dichloride  (ISO)
iron(0)  (EXP)
iron(III) nitrilotriacetate  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
ketamine  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP)
lutein  (ISO)
melatonin  (EXP)
menadione  (ISO)
metformin  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (EXP)
Muraglitazar  (ISO)
N(4)-hydroxycytidine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (EXP,ISO)
N-ethyl-5'-carboxamidoadenosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naphthalenes  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
NMN zwitterion  (EXP,ISO)
nobiletin  (ISO)
ochratoxin A  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
propiconazole  (EXP,ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
Tesaglitazar  (ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
tributylstannane  (ISO)
tricalcium bis(phosphate)  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood homeostasis  (IAGP)
abnormal cellular respiration  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal circulating phospholipid level  (IAGP)
abnormal gluconeogenesis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal ileum morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal mesenteric lymph node morphology  (IAGP)
abnormal NK cell morphology  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal response of heart to induced stress  (IAGP)
abnormal retina morphology  (IEA)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IEA)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cellular glucose uptake  (IAGP)
decreased circulating alkaline phosphatase level  (IEA)
decreased circulating antithrombin level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating sodium level  (IAGP)
decreased NK cell number  (IAGP)
decreased NK T cell number  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased ventricle muscle contractility  (IAGP)
hematuria  (IAGP)
hepatic steatosis  (IAGP)
hypoglycemia  (IAGP)
improved glucose tolerance  (IAGP)
increased bleeding time  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased cardiac cell glucose uptake  (IAGP)
increased circulating calcium level  (IEA)
increased circulating cholesterol level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating ketone body level  (IAGP)
increased circulating lactate level  (IAGP)
increased circulating phosphate level  (IEA)
increased circulating potassium level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating VLDL cholesterol level  (IAGP)
increased fatty acids level  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased insulin sensitivity  (IAGP)
increased liver weight  (IAGP)
increased lymphocyte cell number  (IAGP)
increased muscle cell glucose uptake  (IAGP)
increased partial thromboplastin time  (IAGP)
increased prothrombin time  (IAGP)
increased regulatory T cell number  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased T cell proliferation  (IAGP)
increased total body fat amount  (IEA)
kidney failure  (IAGP)
liver degeneration  (IAGP)
macrovesicular hepatic steatosis  (IAGP)
microvesicular hepatic steatosis  (IAGP)
no abnormal phenotype detected  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis. Dutta KK, etal., Lab Invest. 2005 Jun;85(6):798-807.
2. Identification of novel differentially expressed genes by the effect of a high-fat n-6 diet in experimental breast cancer. Escrich E, etal., Mol Carcinog. 2004 Jun;40(2):73-8.
3. Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals. Hui TY, etal., J Biol Chem. 2004 Jun 4;279(23):24387-93. Epub 2004 Mar 26.
4. Vitamin D3 up-regulated protein 1 (VDUP1) expression in gastrointestinal cancer and its relation to stage of disease. Ikarashi M, etal., Anticancer Res. 2002 Nov-Dec;22(6C):4045-8.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Deletion of Thioredoxin-interacting protein ameliorates high fat diet-induced non-alcoholic steatohepatitis through modulation of Toll-like receptor 2-NLRP3-inflammasome axis: Histological and immunohistochemical study. Mohamed IN, etal., Acta Histochem. 2018 Apr;120(3):242-254. doi: 10.1016/j.acthis.2018.02.006. Epub 2018 Feb 23.
9. Redox proteins thioredoxin 1 and thioredoxin 2 support retinal ganglion cell survival in experimental glaucoma. Munemasa Y, etal., Gene Ther. 2009 Jan;16(1):17-25. Epub 2008 Aug 14.
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. High glucose-induced thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-beta1. Qi W, etal., Am J Pathol. 2007 Sep;171(3):744-54. Epub 2007 Aug 3.
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus. van Greevenbroek MM, etal., Diabet Med. 2007 May;24(5):498-504. Epub 2007 Mar 22.
16. Catalytic degradation of vitamin D up-regulated protein 1 mRNA enhances cardiomyocyte survival and prevents left ventricular remodeling after myocardial ischemia. Xiang G, etal., J Biol Chem. 2005 Nov 25;280(47):39394-402. Epub 2005 Sep 19.
Additional References at PubMed
PMID:8889548   PMID:9537422   PMID:10349636   PMID:10843682   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11252174   PMID:11376942   PMID:11473059   PMID:11753387   PMID:12477932  
PMID:12706526   PMID:14531794   PMID:14610273   PMID:14681479   PMID:15173414   PMID:15489334   PMID:15520447   PMID:15696199   PMID:15723808   PMID:15782199   PMID:15930262   PMID:16141072  
PMID:16141073   PMID:16254043   PMID:16607285   PMID:16766796   PMID:17143286   PMID:17582205   PMID:17916779   PMID:17998203   PMID:18171713   PMID:18322014   PMID:18344994   PMID:18425727  
PMID:18552236   PMID:18554416   PMID:18555775   PMID:18793170   PMID:18974273   PMID:19223654   PMID:19244202   PMID:19267992   PMID:19327827   PMID:19605364   PMID:19619006   PMID:19625652  
PMID:19764881   PMID:19809375   PMID:19875615   PMID:19906978   PMID:19959470   PMID:20023662   PMID:20156484   PMID:20299477   PMID:20624390   PMID:20692333   PMID:20713078   PMID:20826751  
PMID:20838331   PMID:20844768   PMID:21119640   PMID:21145821   PMID:21267068   PMID:21377456   PMID:21439280   PMID:21508227   PMID:21510938   PMID:21771725   PMID:21873635   PMID:21908621  
PMID:21917648   PMID:22112787   PMID:22201682   PMID:22267843   PMID:22366181   PMID:22750447   PMID:22768160   PMID:22815502   PMID:22869588   PMID:22883233   PMID:22883234   PMID:23246829  
PMID:23329835   PMID:23349187   PMID:23454121   PMID:23520550   PMID:23584856   PMID:23584857   PMID:23715727   PMID:23718729   PMID:23820201   PMID:23823478   PMID:23975026   PMID:23976953  
PMID:24037087   PMID:24098117   PMID:24194600   PMID:24198286   PMID:24283717   PMID:24482226   PMID:24492284   PMID:24515523   PMID:24627476   PMID:24684304   PMID:24843047   PMID:25003952  
PMID:25015733   PMID:25138219   PMID:25145386   PMID:25329456   PMID:25391656   PMID:25600403   PMID:25834832   PMID:25855771   PMID:25916556   PMID:26062991   PMID:26410627   PMID:26796253  
PMID:26806835   PMID:26858253   PMID:27037370   PMID:27131835   PMID:27199118   PMID:27497988   PMID:27626380   PMID:27702549   PMID:27725089   PMID:27929088   PMID:28099758   PMID:28202418  
PMID:28322443   PMID:28499273   PMID:28591573   PMID:28669627   PMID:29101219   PMID:29169415   PMID:29203232   PMID:29278702   PMID:29322219   PMID:29401599   PMID:29475133   PMID:29477360  
PMID:29749372   PMID:29813102   PMID:29884908   PMID:30138646   PMID:30142540   PMID:30168649   PMID:30208322   PMID:30387131   PMID:31241142   PMID:31561358   PMID:31620121   PMID:31678323  
PMID:31781121   PMID:31900750   PMID:31939095   PMID:31982825   PMID:32005751   PMID:32084370   PMID:32096759   PMID:32402333   PMID:32492941   PMID:32726606   PMID:32892306   PMID:32892310  
PMID:32902872   PMID:32927265   PMID:33128997   PMID:33190588   PMID:33274003   PMID:33349852   PMID:33460751   PMID:33508319   PMID:33652022   PMID:33847261   PMID:33875790   PMID:33901495  
PMID:34029695   PMID:34085839   PMID:34103662   PMID:34162834   PMID:34348139   PMID:34348577   PMID:34708032   PMID:34709266   PMID:34774846   PMID:35098371   PMID:35129674   PMID:35148667  
PMID:35583913   PMID:35644243   PMID:35883151   PMID:35957590   PMID:35980563   PMID:35993020   PMID:35994650   PMID:36316322   PMID:36448450   PMID:36450326   PMID:36624847   PMID:36773839  
PMID:36888974   PMID:37095099   PMID:37153733   PMID:37168572   PMID:37349316   PMID:37456843   PMID:37686390   PMID:37850269   PMID:37879955   PMID:38069134   PMID:38072375   PMID:38103409  
PMID:38142581   PMID:38169654   PMID:38349408   PMID:38417829  


Genomics

Comparative Map Data
Txnip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,465,273 - 96,469,173 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,465,273 - 96,469,199 (+)EnsemblGRCm39 Ensembl
GRCm38396,557,957 - 96,561,857 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,557,957 - 96,561,883 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,361,880 - 96,365,780 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,643,362 - 96,647,271 (+)NCBIMGSCv36mm8
Celera397,964,967 - 97,968,875 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.93NCBI
TXNIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381145,992,435 - 145,996,579 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1145,992,435 - 145,996,579 (-)EnsemblGRCh38hg38GRCh38
GRCh371145,438,490 - 145,442,635 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361144,149,939 - 144,153,882 (+)NCBINCBI36Build 36hg18NCBI36
Build 341142,927,625 - 142,931,567NCBI
Celera1119,641,815 - 119,645,987 (+)NCBICelera
Cytogenetic Map1q21.1NCBI
HuRef1119,402,325 - 119,406,521 (+)NCBIHuRef
CHM1_11147,360,561 - 147,364,757 (-)NCBICHM1_1
T2T-CHM13v2.01145,109,270 - 145,113,414 (-)NCBIT2T-CHM13v2.0
Txnip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,781,933 - 186,785,736 (+)NCBIGRCr8
mRatBN7.22184,093,079 - 184,096,882 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,092,991 - 184,096,886 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,764,537 - 191,768,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,557,131 - 189,560,931 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,397,095 - 184,400,895 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,683,168 - 198,686,971 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,683,159 - 198,686,974 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,170,102 - 218,173,905 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,356,954 - 191,360,757 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,319,631 - 191,323,506 (+)NCBI
Celera2176,618,301 - 176,622,104 (+)NCBICelera
Cytogenetic Map2q34NCBI
Txnip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955568103,762 - 107,785 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955568103,801 - 107,791 (+)NCBIChiLan1.0ChiLan1.0
LOC100971374
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21105,244,606 - 105,248,842 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11104,844,009 - 104,850,270 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0190,007,878 - 90,012,055 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11113,902,839 - 113,906,239 (-)NCBIpanpan1.1PanPan1.1panPan2
TXNIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,775,588 - 58,779,730 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,776,871 - 58,779,531 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,243,550 - 58,247,684 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01759,772,252 - 59,776,384 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1759,772,252 - 59,776,378 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11758,645,076 - 58,649,209 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01758,706,219 - 58,710,353 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01759,432,672 - 59,436,806 (-)NCBIUU_Cfam_GSD_1.0
Txnip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,846,422 - 20,850,485 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936867722,514 - 726,617 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936867722,544 - 726,595 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,348,490 - 99,352,755 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,348,589 - 99,351,760 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24108,991,390 - 108,994,561 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TXNIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12012,756,145 - 12,759,853 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2012,756,053 - 12,761,177 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603815,433,418 - 15,437,640 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txnip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477217,341,630 - 17,345,960 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477217,341,918 - 17,345,964 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Txnip
123 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1203
Count of miRNA genes:513
Interacting mature miRNAs:595
Transcripts:ENSMUST00000049093, ENSMUST00000074519, ENSMUST00000128221, ENSMUST00000144639, ENSMUST00000151832
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse

Markers in Region
AA682105  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38396,561,580 - 96,561,734UniSTSGRCm38
MGSCv37396,365,503 - 96,365,657UniSTSGRCm37
Celera397,968,598 - 97,968,752UniSTS
Cytogenetic Map3F2.2UniSTS
Whitehead/MRC_RH31101.47UniSTS
RH98174  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38396,558,419 - 96,559,086UniSTSGRCm38
MGSCv37396,362,342 - 96,363,009UniSTSGRCm37
Celera397,965,429 - 97,966,096UniSTS
Cytogenetic Map3F2.2UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001009935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_023719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF173681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF282825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF282826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF449447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000049093   ⟹   ENSMUSP00000041467
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl396,465,276 - 96,469,173 (+)Ensembl
GRCm38.p6 Ensembl396,557,960 - 96,561,857 (+)Ensembl
RefSeq Acc Id: ENSMUST00000074519   ⟹   ENSMUSP00000102710
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl396,465,273 - 96,469,199 (+)Ensembl
GRCm38.p6 Ensembl396,557,957 - 96,561,883 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128221
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl396,467,370 - 96,467,881 (+)Ensembl
GRCm38.p6 Ensembl396,560,054 - 96,560,565 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144639
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl396,467,039 - 96,469,174 (+)Ensembl
GRCm38.p6 Ensembl396,559,723 - 96,561,858 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151832
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl396,466,814 - 96,467,329 (+)Ensembl
GRCm38.p6 Ensembl396,559,498 - 96,560,013 (+)Ensembl
RefSeq Acc Id: ENSMUST00000196871
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl396,466,827 - 96,467,520 (+)Ensembl
GRCm38.p6 Ensembl396,559,511 - 96,560,204 (+)Ensembl
RefSeq Acc Id: NM_001009935   ⟹   NP_001009935
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39396,465,273 - 96,469,173 (+)NCBI
GRCm38396,557,957 - 96,561,857 (+)ENTREZGENE
MGSCv37396,361,880 - 96,365,780 (+)RGD
Celera397,964,967 - 97,968,875 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_023719   ⟹   NP_076208
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39396,465,273 - 96,469,173 (+)NCBI
GRCm38396,557,957 - 96,561,857 (+)ENTREZGENE
MGSCv37396,361,880 - 96,365,780 (+)RGD
Celera397,964,967 - 97,968,875 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001009935   ⟸   NM_001009935
- Peptide Label: isoform 1
- UniProtKB: Q9EP90 (UniProtKB/Swiss-Prot),   Q9DC00 (UniProtKB/Swiss-Prot),   Q8K2B2 (UniProtKB/Swiss-Prot),   Q8BGQ0 (UniProtKB/Swiss-Prot),   Q9R115 (UniProtKB/Swiss-Prot),   Q8BG60 (UniProtKB/Swiss-Prot),   Q91X82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_076208   ⟸   NM_023719
- Peptide Label: isoform 2
- UniProtKB: Q91X82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000102710   ⟸   ENSMUST00000074519
RefSeq Acc Id: ENSMUSP00000041467   ⟸   ENSMUST00000049093
Protein Domains
Arrestin C-terminal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BG60-F1-model_v2 AlphaFold Q8BG60 1-397 view protein structure

Promoters
RGD ID:6833291
Promoter ID:MM_KWN:35393
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000090771,   ENSMUST00000098839,   OTTMUST00000050413,   UC008QND.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36396,361,001 - 96,362,402 (-)MPROMDB
RGD ID:6834590
Promoter ID:MM_KWN:35394
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000050415,   OTTMUST00000050416,   OTTMUST00000050417
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36396,362,571 - 96,364,207 (+)MPROMDB
RGD ID:6881680
Promoter ID:EPDNEW_M4291
Type:initiation region
Name:Txnip_1
Description:Mus musculus thioredoxin interacting protein , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38396,557,960 - 96,558,020EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1889549 AgrOrtholog
Ensembl Genes ENSMUSG00000038393 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000049093 ENTREZGENE
  ENSMUST00000049093.8 UniProtKB/Swiss-Prot
  ENSMUST00000074519 ENTREZGENE
  ENSMUST00000074519.13 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.640 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Arrestin-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56338 UniProtKB/Swiss-Prot
MGD MGI:1889549 ENTREZGENE
NCBI Gene 56338 ENTREZGENE
PANTHER ARRESTIN DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN-INTERACTING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Txnip PhenoGen
SMART Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q8BG60 ENTREZGENE
  Q8BGQ0 ENTREZGENE
  Q8K2B2 ENTREZGENE
  Q91X82 ENTREZGENE, UniProtKB/TrEMBL
  Q9DC00 ENTREZGENE
  Q9EP90 ENTREZGENE
  Q9R115 ENTREZGENE
  TXNIP_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8BGQ0 UniProtKB/Swiss-Prot
  Q8K2B2 UniProtKB/Swiss-Prot
  Q9DC00 UniProtKB/Swiss-Prot
  Q9EP90 UniProtKB/Swiss-Prot
  Q9R115 UniProtKB/Swiss-Prot