Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Becn1 (beclin 1, autophagy related) Mus musculus
Analyze
Symbol: Becn1
Name: beclin 1, autophagy related
Description: Exhibits protein homodimerization activity. Involved in several processes, including amyloid-beta metabolic process; engulfment of apoptotic cell; and negative regulation of cellular metabolic process. Localizes to several cellular components, including the autophagosome; phosphatidylinositol 3-kinase complex, class III; and trans-Golgi network. Predicted to colocalize with the mitochondrion. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Machado-Joseph disease. Is expressed in central nervous system; extraembryonic visceral endoderm; retina; and spleen. Orthologous to human BECN1 (beclin 1); PARTICIPATES IN autophagy pathway; inositol metabolic pathway; mitochondrial autophagy pathway; INTERACTS WITH (-)-citrinin; (S)-nicotine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4921513J16Rik; 5430417M23Rik; Atg6; Bcl-2-interacting protein beclin; beclin-1; coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; MGC6843
Orthologs:
Homo sapiens (human) : BECN1 (beclin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Becn1 (beclin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Becn1 (beclin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : BECN1 (beclin 1)
Canis lupus familiaris (dog) : BECN1 (beclin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Becn1 (beclin 1)
Sus scrofa (pig) : BECN1 (beclin 1)
Chlorocebus sabaeus (African green monkey) : BECN1 (beclin 1)
Heterocephalus glaber (naked mole-rat) : Becn1 (beclin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl11101,285,952 - 101,302,286 (-)Ensembl
GRCm3811101,288,258 - 101,302,286 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711101,149,581 - 101,163,581 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611102,067,439 - 102,081,397 (-)NCBImm8
MGSCv3611101,104,357 - 101,118,357 (-)NCBImm8
Cytogenetic Map11DNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Becn1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736173
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.